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ORIGINAL
Zrvons 0 TECHNICAL REPORT SUMMARY
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To TECHIES COMMNICATIONS CENTER ~ Z0VECH A ----
pR226- 0782
rToAL - Analytical and Properties Research Laboratory
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Trace Fluorochemicals in the Environment
A000006
IRDC 137-092: PC-95/Monkey
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Chemical/Analysi:
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Requestor: J.E.
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RE
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Long;
TREE
yoni Raported
Request #A69507; Project #9172110004
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Contain HC GBI
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CENTRAL ANALYTICAL LABORATORY
Report No. 6967 _ooennns
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Date. _...A4u.g19u7s8.t...
Subject: IRDC 137-092: PC-95/Monkey
Requestor: ..I.E.-Long---
Dept. Name .T0icology..
Request No. A6I507 ______
Dated eo 8/8 eee
Report:
Proj. No.9172110004
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Group Fi bY
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SERUM ANALYSTS
Dosage Level 0
0.5 mg/kg/day 1.5 mg/kg/day 4.5 mg/kg/day
survival aa ara 4/4 0/4
onkey "lank on Method
Dosage Level -
FC=95 in serun (ppm 2
7355M
0
40
7358
0
20
73688
0
15
7463n 74868
0.5 mg/kg/day
150
.
150
74621
1.5 mg/kg/day
250
75008
.
275
gPursecinseiwolny diseveelsotpimeadtepdyrotloysbies m10eth-od254w.as used.
i. AR. 86967
-2-
August 8, 1978
LIVER ANALYSIS ~. The high levels of FC-95 in the control serum cannot be explained.
'
For example, 7355M was run on 2 different
dreetseulrtnsi.ne Piferhtahpiss alevteoltalof fFluoisrinperessehnotu.ld
days with
Sbeee ruTnabloen
the same experimental
btehlisowscaomnplteaintiong
liver results for further discussion (Footnote 2).
-
Monkey
23554 73688
74634 74668
7462m 75008
7484
7502F
Dosage Level
0.5 mg/kg/day -
1.5 mg/kg/day .
4.5 mg/kg/day
-
PC-95 in Liver (gD
3000 15002
7000 2000
45000 40000
10000
80000
50 FC-95 in Liver (ppm) 202
100 100
650 500
650
1000
o The livers were stored in
analysis resulting in the
the refri: gerator several months
separation of some liquid. The
prior to
high values
and physical size necessitates taking only partial livers in whieh
wcaasse tathkeensafmoer raantailoysi(se.stimInateadddivtiisouna,llyr)ecoofversyoliodf Ftoo-3s5epwaareateedotilnidqeunigd
from experiments where FC-95 was added to a control liver.
control levels. @ yecause of a higher than expected value for the control, a 0.133 g
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