Document ypbrKMwnRamL6gqLb9wwGQEZn

April 0, 1957 Mr* Jaaea 0. Lofntroa Standard Oil Company 30 Rockefeller Plaxa Mew York 20, How York Daar Mr* Lofstrooi X have boon asked to forward to ycitj toxicity data on our fluids, fydraul 7-9, Fydraul 150, /rydraul 60Cb and Fydresul AC* WmkZzSL There haa boon considerable toxicity research an rydraul 7-9, Attached la a dlaouaaion and interpretation of tha toxicity studies. The results are also suaaarlsed in a briefer fashion on page 18 of the attached rydraul 7-9 Technical Bulletin. fydraul 150 The tealsitar report on fydraul 150 indicates that It la praotlsally innocuous when fed orally to rate einoe the survived single doses of 26,5 erase per kilogroa with loee of appetite sad severe diarrhea as tha only tootle effects. The fluid apparently is not absorbed through the unbroken skin of rabbits since this epeeies survived doaea up to 9.5 grans par kilograa of body weight. In rabbit skin and eye irritation studies, rydraul 130 was no sore irritating than a 100 soap solution tested similarly. As indicated with Tydraul 7-9 above, hwsever, rydraul 150 will ecuse severe pain if there la accidental splashing in tha eyes of huaaaa. Bats survived a 6-hour exposure to an ataoephere saturated with fydroul 150 vapors. tttettLiSg The oral lethal dose for rata la approximately 30.5 areas per kilo graa. then spited undiluted to the unbroken skin of rabbits the lethal 4eee was froa 3.9 to 5.2 greas nor kUoaran. Animal skin and eye Irritation studies indicated that rydraul oOO is not s akin irritant. Ms knew froa experience with humans that occidental splashing la the eyes does cause severe pain but no peraanent Injury, Rats survived a 6-hour expooure to an ataoephere saturated with the vapors of fydraul 600. QSW 018652 STLCOPCB4005196 Nr. 9mm 0, Lofstron-Pts a--April 8, 1957 ftitKM th ml lethal do* in ret* is apprexlaately ^ sraaaa per idLiosran ad the tnlsnw lethal doe* by akin absorption (in rabbits) is 4,0 bo 50 tnsi p#r kllegrasi. Rabbit skin and eye Irritation studios Indioat* that Pydrsul AO is not a serious irritant. Aooidental eontaet nth tho eye in tho ease of honana will rosalt in irritation but n pewianent dinag*. Rats survived a 6-hour exposure to an ataoephsre saturated with vapor* of Pydraul AO, It X ean be of any further assistanoe, please let as know, 3lnoerely yours. STVidh Easloewes o Mr. II* 0. Mvanmr Elaor ?. Wheeler Assistant Director Nedloal Departaent OSW 018653 STLCOPCB4005197