Document ypbaZR2erZayGXkaZ2OGMEXmr
* #'
( ff 99 # # # f # #
IT
I| !
1
*4jVlO 5friO
bt * i * * #
***
1* ' * * * * * * * *
#
!
#* ; #
itt *
*: # * *
* **
*
* I*
* *
*(*
*: * *; *
*
*
* *
** ** Ht * * !*
jo jo
HOr; tO*C4 0^O
00: <0
*4 *4 SO P30 CO 10 Ov
9*
*** #
*
# # i*
! i
h
ltd Q O U
23 <
Cz aii.
tLni
Q
II U1l
c .
CSI
It a o z Q ? Ui it Ui u u. <
Qt SZi.
Id w Q O s * * * *
a:
foeiI so
N Hfl-
O id X It ; K. b-i: rf*> <N ~ to SO 10
r* m
Ul
b>l:
-1 t
Q`I. I O12
' U!
Csxiii Qo
<u Z; -J
Q<xjii IO- !i
U;
<: U. I ** ; * *; * ** # : * *i *
l
0* SO
** CCoSMS
At
<
H
<C
>
o
BO z
o p u
!* j# \* I# * *
OC rOkt H
10* 0m*' OO---*t O*H*4OOw-<
boWouL! >o*s4
*4 *4 *4; >->->0S.0JJCSLSP
*< X0* safo&******<-.
4> *> tl <
z
o * # * * * *
rjrs I I - *1
N36868
hi
>
bi
-2 - y e a r LEAD-FEEDING s t u d y DOSS URINE ANALYS IS DATA.. (Y30) ................................ PAGE.............. 2
(e x p a n d e d d a t a m a t r ix i d e n t i f i c a t i o n : i n p u t d a t a r o w n u mb e r , e x p a n d e d d a t a r o w n u mb e r , f a c t o r
"Y 30=D -A ts....... ...tO O r~ A a r .............. ................................... -............................................ -................... .........................................
OHIaOH
st *0}m JO
[JA 01 O'
SFO-
O'
HNtftyj HW4r f-i o **
CiS n ioi ctf
wt H
33 0; 0 5 Oo =r** i! O
.M *lO M* 4-tll\!> O '
0
if
og2fel
ti if
an < h05 l<-
hiQ
JZ
Ho4w
m (A
W oz
VJQlfLl oo
hi LU
D hi hi p UQUOJ aQ&t .2 L>Sin3:lH zM oK Co]xUJ
Lh.ii.b-
5 O OO
3Z 0Z 0Z 0[Z
in
******
Va O N Y ******
4$ **t $ * ^ **
... ..... ~
PA@E
,
3-YEAR LEAD-FEEDIN STUDY - D06S URINE" " ANALYSIS DATA (Y30)
RESPONSE..NUMBER F ..... ~~T3Bb o - A I T "........~...... ................ ..
o olo o o nce^oo
oooooooooooo C3 0 0* OrffftjHHtOlQOO
O 00:000
oootjH<oe
d* r-ev\0m
'd
50 (O
o to OOOOOOOOOOO O OOOOOjOOOOOO jo o
drCM0'0oivfol||UO3hNOoUio}iO,*Ha<Wi*H-fH\ODWfdfi'I!fOM,*ofnOeOO>niH,>oniOOrt>cWoHdlO(,Ul,*f"tMl*WHSiiH<-HAidHK*PyO-COOiJJHOiOO<:iHfdl'l4O'0-
MOlSOd'WSDf^COO'W CM k> d*m b i**cot0 -i ojfo it mb f*ao!o**-csnod,io*0r**<pH * * w io d-m A
o
d* so r^olo* h
<1*-#*-* HHNA1 BIWCBWNWWl<)W;lOJ<)W|lOWlOn*datd`4i^it^|t'H*4iHH|rtrt*^WWWWWaiWWftl
M*4HH H
tMH
DUP050309169
f% ^ ^
\ '% t %
^:
^
1
PAGE
090 9 90 0 O <9 s j s o b o n
S9 0OV n *M HTOJ
o
o o o 909 0 0 9 o o
ooo ooo O 0 9 0O 9 ooo
to *4y O ooa biAb Qoooon *i^ca OO fit enonoto OaDO
pHOIrtOtOaO aO 1*3 I^P- ION h to to <o
ow(oo{ -icy c m
9I4 piH
0>"f to *tor ntaoAOHo P- ^<0; -icy st ocyw HHtHtnirt Kscy;
8-YEAR LEAP-PEEP IN6 STUDY PO PSU R IN E ANALYSIS DAtA <Y30)-
|
ib* f> ao p- post *-jaf io atp) io p-
cuiOtfpb^ o.o* <4K<m ntor*- co auo^jWAOt* is c* -tyu to At;
(OlOlO
a* :t
-I -t W W CM W |W CM W WtM 10^0 #* O fOK> ft IO fit at St fit it St t --!> * -- p <
ftftftWWW MWWWWWAIWWWWW u c m o W * to|?o rt K) (Oj OMJ O rt to IQ to 0 ooiQpno OtOtO n to o ft ft *0
oota* ta*; it fit P's
W** w
<rtrlHM f IH
K4H >4p ( ( rt W H HrtH r>4 H --i
--I --I;
-f4r>
eg*
# It
m DUP050309170
oo o
OO0k
ooo
W #*
ao}e)6ooeeo4o{bMoMo(4ieaiopjat^ooooioq n ctfar-fOiowwwttfwiow weioi
O GO
cWa
O
it>OS
O O O 0,0 o o o o o y!w toleo All** ICO GO w
Gsniitw- wAt (n0h!Oo CO 1H0iCk otftAOt ^01
aoooooooooooo oooooooo oooiooo ^H-NEwnHoSi oo"^n3tSdoro'oiSuoSMoco^oOSii-oMO^kooHbJ^OoNWiNoO4jMBfS<}ou^i5so)^!,*<odo*>olOioinWw:idoa'of^sc^joIt *)^*^ooCoSol
(A
CO O' * WIO sfr io ,*o r* O'WWJOiJ-lfl^CT-ltOO' wlctflO
f^jeO O^wkwiOtf ta 'Of* BMP W)W0if!O
pncy I9tf Jfl
COC'H Alio <*;
wwo j w eiN ct* W Ol CVJ CUfOfOlO JOOtOJOlOa'!#rf` s**'s* & 3*' S$* WW H H wwwwwcuftjcuttNAjAjru a}ioio?om?r>tosonro& st'Jtf'
a* :* so* st 4*
sr*5O$r>sf>tfJU,!tDtoi0iatf>y!Ji0tf>s*inieii>tfJiDtf3S5E3iiO*nti>kns 0 tf> tf) |
w h w w rS w|w w w w w *
n w w w w*w w Wj
W W W jW H W r| H W * + W W W W W W W
w ww
=
tts DUP050309171
>**>. -J** 7*
q
tft :
=3=*
-# # $ f ; J**k ** ,**
#!
o 0
oo O 0*
0 M*0O0*W0 a**1 "
C1^O0a0r4so4fr*
ooeisooboooo o o4niMbd>Hpon
AfOjfMhAlfOCQod^^lS
oo too
CmM to
oo 0 0 O 0-0 OOO 00000000000000000:0 oooo oio o o (4h i8 tf>ko a i^s o eo -<h o h e o w^aNoftio w waopp-or^O'WJ^oo
<tuftHnct4f enstefo)tcfol0mc0v 0iid]4oj>iai4j*,HNOHbIl4Q,84l>nm$a0e'04ID^oO*'0ov|H9>I'fMl k0O^(Jnii^SjdM-OlOHo^Nto-a&sOo coy
OS U<>i|S0 c MI
MOd'lfl'ON ax^HKsio^ O
0V M cy io 4i*Q \0 H 0 MCM to d-
Mio3->Of*l0`"-nMmj*-iin<or-0''rto(Wjc
r i aj cijoj w ai MK)WlCtO 0f0i0l0l0 4* 4 at- 44* 4 4;4 4 MM h w
McywTMwc\iPjcuniO(0!03otojoifO^-:a-3-3-
4 4- sf* ;4 3* 4 4 0 4* ' 4 4 444444 3* -j- 4:4 3* 4j4 4 tf) tf) 20 tf> n & to io gj in nmiatnsnaijosoajlnsoinioinsnsiinmsointfl;
HHrtwMM
pfriHH H M 4f44*4r< M Hrt HrtrliM H M
# %I
TO?
*
* " DUP0503091 72
'f 9 ? ?
%
* -?
2#
9 -* &
9
PAGE
09 0 HOCO HO^CO cniS^c moifil OtGlwtaf
O OOO OO 0 0 0*000
<tO<0;lD 4*01 ~llO M*4f4kV4iO
O O Oi OOOjO OO
OOhfi
30-f h <d <S
enir-oao
lO H4<i OlH HjO) 1 CM
0 OO
HO** o*0 Iftifi*HAI2 4 W
DOOiOOO HtOP4tD
^Afeiiipmieoi
OOO
on>o QON 4-00
OO0 ooo toion WO'00
^otn'M<DW 0190* 944 nio O 00
ooo oo o oo oi O' ON NtRM r a o cdo 0 0 Cft <0[ft 0IO Q4W 4>1O\0
2-YEAR LEAD-FEEDING s t u d y DOSS URINE ANALYSIS DATA (Y3Q)-
o Aioiton^ S' fr s* |4- 4- 4l U N6t;fC4A|
4 CMWrf-
99< M tO4*j 0 ^ OOtH WI04 0 \Q NjtO^
H-tM N MM CM WM WWW K5 into io totftirtia st
a j o a 0 id D ID SOfeft ift tO 0 00 a 00 a 0 0ita 0 0 0 0
mm at UQtM M M Oljw M M WWW 02 MM EU M MiMMM ;NWW
DUP050309175
-> > a> * # ^ ^
V*
I
i I
_____PAGE
2-YEAR LEAD-FEEDINS STUDY -D O S S U R IN E ANALYSIS DATA (Y30)
boinoool
o *4
4)
Ct
10 4)
:SO in ;* 510
1X3 tO IO Ctf on
/ 'flr* '*
CSS
i
CTT s*
DUP050309176
*E-YEAR LEAD-FEEDINS STUDY DOSS URINE ANALYSIS DATA (Y 30)
RASE
DUP050309181
-2 - YEAR LEAD-FEEDING STUDY DOGS URINE ANALYSIS DATA <Y30>
PAGE
DUP050309182
% i * .* v * < f f
9R9EH
:#
#
#F | M'
<c
CXIiro in 0
hi *JJ J JJ fcJtU UhSlijlaj *jtL
IUU1&I hlhiiy - ` I E tI HtiiiAi'in
SYMBOLS USED N 2 - AND 3-Wa Y MEANS PLOTSI
DUP050309183
-2-YEAR LEAD-FEEDING s t u d y DOSS URINE ANALYSIS DATA <Y30>
PASE
- .SEX............ ................... MEANS........................................... .........-....... .................-.... -..pB-LEVe L ........................ MEANS
DUP050309184
4 HI 4* I K I
I
4 M 4- m
o
+ h i fc* ft} KH I I IO I t+ *
S* io
t <9 ft!
ao I o 1v0 + I
HUbJ S
SuJ
U> It Ui
o
1 St
OJ
+* I
IO
3* 4:
I t
* o
*I ft}
.i1t CM
t
l
I ,4 HtH + H 4* h * +|h * + H
j H * <t
0.1
Kui
in
>- i
4- M 4* >* + *-*
I O':
in i
** K/) >C
m;
3S : C 1
so
o
O> : K -*j
3! 4*
CU
CoO i
i t fo i o
1*
i f I I
fl
to
I
Z :
t t 4 M >f|H
Ii o
o 4 h i 4|h + i-i + *
bI. :HUaCI::
C < Ui >-
at u>ai
t
SL
Hi
,
f,B
DUP050309185
DUP050309186
*T&AXL-0I1 .................M IM M -a M U ...... .................................... ............................... ...............X 3 S * ............
-03 39Vd
<QEA> VtVg SXSA1WV 3NIW1 S9oQ ACKU5 9N l033d-aV3T
-a-YEAR LEAO-FEEOING s t u d y DOGS URINE ANALYSIS DATA (Y30J
PAGE
El
" "'SEX................-- .. .........* TTME-FERIDd ....
* PB-LEVEL............................ SEX..... ..............7 ...... * T lW - F E R lffi...... ..........* pB -L IV e L
SEX
AT LEVEL HALE
SEX AT LEVEL FEMALE
+ 4
* CVS *
<VJ
H +!- 4*
m m
* j*
M >3*
+m + w
til 0.
3iJ 3E *-* H-
+M+N +
if) 1 so
3) Ifi
tfoll
+M
+ H + - * !>-4
w
fifr
02
N+1
H+
I; I I iO 1-0
+i*
}*
I iO
t I ,'o
I l!+ H+
CM IS*
10 H|*Hf:
I0 =} +
* I
I ;o 104
+ i*
I
s
Io
IH
IO t :0
1I IO 1*0 + I;
lie
I 90 "*1 ` *
I
I:
l ;o
i
1*
I;
I lo
I Of
o
DUP050309188
DUP050309189
T
O-tsfr>l
-f ^0 *'> m *
JOCOtt'
M* tOo *<oM C0* t- o0wJ* ) fO j s-
i-w st^QCi n*GO> to at so m?
j*naof si*co !eifr jo*c m <*j*
CerMCMO^MNOOJvoACtD:OC' oO'seO a* 1H0(oMj*aifcoo fhlif;l0iMH^e0i0o<ina
Cf
a
fO
o
CSIWKJ
r-i m
0kWd*<J'OC0C0p00cf*0O^MCMOtfQf<>0'f^POCUO
* w *> i- o h & < m o j b to ar aj g> 2 gig 2 >rf 2
dOd'-' tiffof)lsWCoO
or*
>IO^\NC
rtlOO' CM CM IO
wt W
O' CM
f*J St
^e>oN>i,
oin^ SO<flN jOC* W esj to sf tt> i*- C3 O' H M =f i* wcMro^snor*}saa*wcumsfin \or c* w *mio ^s o Nio^iiA^ON
*
i town m
10
to
tt>-!o
10 st
& st
&`ft &
st
;f
rt;HH H
HHHHcuoiMcusiiNctijAioftoion Annonotf kst- st st st st lst at h w h w |<h h w
^ntat CM CM oa CM CM CM CM CM CM CM CM CM CM CM 5*3 *) *0 rtfO*o|?oioioiiO!Oto^>(0)o^>fOiotoioioKj(otoioiok3ioyj?ocO!0^o^>5S-ia-!a-^i^a-^
-a vt wjw p< *-t H W-WW H W WfW rt HjH ift W:H H W: H(Ptjf44pMf4HH4HL|p|f4^fti4li4<Ww|H rtjrt WW WHrtiHrtH
5s?*
DUP050309190
;fr f
ff
f~!
fffi
f f
i f c ~~ f' r
CK
I-' ` |
i
I
=
I
> ' !
!
| ** I
rr
-- Ml
r-i
rc-fvooO*i
C* -* C*
{MOiO if dr
n(8o09f O_ i1O0 O50
lOf csi:
to coo*
O*tAN Q1NN
d- Htfj
OjOOIOtQfO gfi f_Q_t_j]to4OOitf0S|hP080fC4O<O--0--i-tO-O---OH--0dOOONJA"0H*l4ft
j- r- do^-^a<t^n
N
a*
O<Xo
M
(0
ai
<v2*o
NwHo
io
W
oCp8-ijrnf-Omodo%-^oi^OwOhcOtModn-'oOo-)OOOpi'^MACOAHf'id-0lOO'|n9OijOf-PH0^d>t^'0WlO8rOo|rtc0*O*mai^n'H0<'ii-MfO&AtvOwW0iAfS>Jlnf*^i(in0oHcHIOr'(t-<0n444W1w0}
;S - icii4<af aHt
ID if
eaca 03 CO S^3 0H0
ii'-i
s*
^. H
b&
)0J
r
AtAdlOiff Niffl OHjCtfOd* 14
*4icg O^H5 O TV {> HjdJAO1 aj r" to o' -*W IO af y> f*!. O' +4 *110 d- # <0 f- O' *4jXiO d*:
CiOJCJ W W Ctf CNJ w to JO *o to IO IO to to IO 9-;sr ^ d- sf sf & st st Hh h <4 r<HHHH<\IMM)Mfl} Ofid !IOP>IOIOf*OJOlOlO*Od,j3fd*d'
d-d'jfjjfsfsfsd-ifd'jd-d-if d-d'd'd'd'd-jd'^d'd'd- jfjsr d-tfkji0tf>fiS>sr>tnsBtf>inififliOtf>sr*>iaSM3tf>ij3*iniifl-4Oifl>knio*j
0101
I !;.;i 01 Oi OJOJd CU WOlid WOJ OJd mIo io io k o io io i oiotoj McycviNcucawojoMat dead oi ca d cw cy oicy wiwcy or
` .... .*53 I
DUP050309194
? <M0
oil
DNiMO t'at r.w!o*o pw<j> ^c
H*4H HW
qc;:
tn\
Os
Oa i
a D1
e
s
e<zja<ON
hi
W>I- tftfd-
tn sn *r> sn
tVJCUCyWCU
S
rf
ff4#
II
*
f- f r r
Iji
** * **
* ft
**
won a* *003 01
< M<0 WtfJ 0 HO fi:
c f ca in-H ro *-
cUel| lO t-*.*-*! =i- W 30 fO Oc +o +O O++0;+:0'+O*"0 {+0 o i0n 0S0O rctfiiattivctiO&iw
OO^OiON^iOO
z< WtAWSft-K0;:*n tZel
!.-
2-YEa R LEAD-FEEDING STUDY 8 h B 5 URINE ANALYSIS DATA <Y30) .................. . ..........PASS
'^c fO ini wj4- in init> tn
o o ooo oo o
+ - + + \ 4> +
Wc\Oj*O2
ifl r*o
CS 4* n^p<4 a i cy o
OJIOHO
oMnc CM to at- *4
v C<*
s*"tt
fO*-'
l-01 03 UJteJ
.J -J
M *"*
< <: Tt
OO
U tel
3te>l >tel -I *J
i m0 0*x Wif OBO 0 CtljOSO 80! soiso 4"
>* >-
(tAel) t0otee1itj <-Jt D OI
StC( O*
D CO
oo
OaS tfi.
<O3 1oX5 o*4
tel tel XX
<!
>-;
as!
% > :
tCOSeBl
Z
L-
O] toel
g
s 4
z<o zo*
4N u. u. HN
iUZof2f
1oUc31e:i;
X
j 0tn1 <
OW OH
z 0z
H Hi 0) (A
Q_
0tKe5J
K
_B H Hi cd i a o 30 < OCX CO
SO
COUO
ft* ft
Cy * >
r- rDUP0503091 96
DUP050309197
?- C f f f
* J- f*
v
Z
r' c i
f f( M j <f
fff r * *p
r
to\
o o a
hi
oc
oj
buhl tftiui
W
ld|S;
U_i o
Ss4
m0J)!\
<f H-
3o5 u: u:: KIX XjfcJ KW
bJi u j I *03 Q.
0>HH
car* Af*4
SSI'S
d-ffi r* u
* *
tm o u j
mow 4 9-
CO-ft-t I** 9010 to e
cur* <4 0 ins**- o r
&>s* Ifl4 H fllO) H|H *4
SUU) eo 'EIOM ore
coin
cam vo
!0
0
4*
HCMO
W-l - *4
Od-JO MO
itofmo
to CO +* [: *
Crt
N-o m ift *>i
prio o 4 4
KHH
*
; S S EL. EL
EXQ. iL EL
EL a (t o
CL o
O Oa
D<4 *-nn
<t s hi IL .J UJ > hi -l
o o
smn Ujo3cku>toccCoJ 4 o*:-tco e
^(fpOO
4 mpuior*
4 HH
m4-mr*r*
4- & CO CO rtNOOP o o*a-u3 o
WiO dO-HNOWNErt
H HHH H
0(0 0>0f
Hdortttoonn;om6o0eno*i
8> Oidd H
sr cu inn rH HHHW
o u*0nt
tdSnT'cNH^IDOoAdOfittiOHo
otonsiuHmieoudo*'
UJ
s
J
SI
#
33. IL
, 2 ESX CL S EL JL CL Q. EL EL CL O O
Qo.^oiOoHoioa
or*
to s
0S(P9 ;
M! O *> *0 Z : ONi Sir .:
to
sr i or*! Sto |
CM
s10* ]:
2*5;
op
troOoiHaQknDkooHi
(OifijDO' iv>br
20 ; 04* i
C4toh*;:
<o
OP -f
IO m o. ! zoi Odr
U1 s < Id
zio I 04* i s ftH!
O o
hi SL I Id
in
hi o 9
H
j
Si
DUP050309198
DUP050309199
-2-YEAR I-EAD-FEE0IN6 STUDY DOS5 URINE ANALYSIS DATA CT30>
PACE
rrrrr
r rrrr r rrr
,, jlr
iP' M:
o> <-icw ora c m atcn feodhOOt Zt[a* o f-.ac. o jW**4*-t>4 *4 a-! y i mwcyor^ew cu f-cco* aO obttOn a- loOctofWta ^
nccooipaoio'Oo' o mj iH
JOCMOf- CM
M4CftasO
hip)9^oeNwrj-iOobno 5 4 iO a nn tcom<toKaM- (cfmi
OOiAa*O^fNO 0^
Da-fa'tftU'
Ioncom**w?
HHWHH
CQ 0i 00 lO'C'
amaio c m cur*- to
*!*9*i ^ 01 OlOf- CM
lOiONAIN H4Hf^H H
p^mCjtoOCtaO o60
M) -<o c m a ! * *4str Klf- EH
l*O# JHO*if4Jcipu a*4>
E9Sh11t<oW4foC*HH*O-WtsjOOoOo zc mc p ch4m psrfa4-
`CaMto Of- F-
fet totf>N a-
if*aniooiii!o_oaa*
_SflELOPLLD.fLi. 2Sl L0o.0o.0oo
PHIO *HttfJ
r*
N i\
-,,11'
u
r'
i b r
is
UPSf
DUP050309200
DUP050309201
m' DUF050309202
r
O
0
*H*W+W + H+H *W 4* ttn
I9 t Of
iS K n
CSI
f +
*
i^
i <o
I *H
I
I K>
f I IH
2* I tn h ?? cst H 1 i
I 5* IH Ie ICO ** o
1H i tn v in
J i KO l fW+M+H + W+W+M
(0 I*-
*F
AT LEVEL MALE
,
............................ .... ...........SEX...........................~....... -pg-LEVEL....................... DOS
RASE 36 *
SEX
S
UJ 3 Li; J CO CL
co * HflW 4> M Hh H 4iM + f *
t in Io tU *S
t A*
1 <0 t -Hi IO I io * f 10 t AS *I iHn IO % c3
I^
!3
I <9 4* tO I ftt (S
> tn fr fo
I O' I Io M 4 jM 4> H +W+M+M \ln.
CO f-
- YEAR LEAD-FEEOINS STUDY - DOSS URINE ANALYSIS DATA (Y3Q)
PQ-LEVEL..................... .. *T SEX'..........................
fOB*
DU P050309203
DUP050309204
<0 \
fO i
fQ iiS-uJ>
tf
m
gp-
<a::*
if, M<f
]iIIIfl U
it
if
*
ft1 Hf
s
H +H+
;s
to * l!<i** fOifrl:
tO
I1 St
tin in + 1*
14* ICS
ItIMw
+ I*
a * lo
4- IS!
4* 1:0
I5*" +ISVi J
to * i
f St
CJ t *H
j* I o
i*
t 4. ;
8
15?
I? IE*
IP* I1 On + M+jtHf +*H + S-* + j*HI + M + M+ !
'f J
4>Mf M4H
* H +!N + I
T'
M8bawC
u.
<uoI. Ul u>I*`doH PJ pac
a.
>- +jH`
+ M. + M f H
H: CV1 SO 4*j W r
DUP050309205
I
--...... rr f
p^ DUP050309206
(* f f f <f t t f- f* f
J3
o H*
lii
9 iff*
W [PS
m4>|h 4*hi( 4 M *4* + w +. M + j*4 + w
1;
If
f ! f
\
-2-YEa R LEAD-FEEDIN STUDY DOSS URINE ANALYSIS DATA (Y30)
' ^ T I W Ts e x ....... ............... .......
HC TB R W B'-------------- iP ft- L E V g r ---------------------------
.. ~ ...
SEX
AT LEVEL MALE
SEX
"
i* S*\
kZi
+ w 4*!h + *+\+ *-+; +*-i+ *** *
*4 a H*>
-PAGE
39
# " T P e p Er T o D
AT LEVEL FEMALE