Document ypag2n62M2E3koLvygqwyqBEX

DLOCY (v - jinn) 12204 IBM. 'in the item lopment of (xilmnnarv silicosis In rats slurtlra on change* in the total, cstrrlflert, tree cholesterol and phospholipid* wpr made in lungs, liver and blood plasma m ~ a period of 200 day*. Total cholesterol, tl (tart Iona and phospholipid content Increased with In the lung* ot alllCth.C an Units. IHs.nrhrmtratty surtaimphlllc lais won' observed In Iha cytoplasm ot pulmonary macrophage*, .gra similar to those of lung* ware not ohnervrd In liver and blood -"jim: the increased lipid contcrg of hings during experimental pul monary alUeosts may be due to the locallxed degenerative action ol Ilka on macrotdagea. T 122288. MUELLER. W,, and C. HOLZAPFEL. (Inst. Arbcttshyg., Unlv., Jena, E. Oer.) Ueber die Bczichunc iw lichen Delta-AmlnolaevuUnsaeure-Ausscheldung lm Harn und Blutblclsplcgcl bel Arbeltcrn mtt unferschledllrher Olelexposltion. [The relationship between ALA In urine and lead In blood In workers with dUfcrcnt lead -exposure. | (NT Arch AROEITSMED 27(4): 431 -337. Ulus. 1911. lEngl. summ.1 --In 3 groups of dUlcrently exposed lead-workers the relationship between ALA [gamma-aminolevulinic acid] in urine and Pb In blood was In vestigated. This relationship is not constant and depends on the kind and Intensity of exposure. It Is difficult to establish an acceptable limit value of the ALA-output In urine. Women seem more sensitive to Pbkhan men. 122289. LIVSHITS. 0. D. O voxmolhnostt tzpot' tovanlya mestnykh pcktlnsoderzhashchlkh plshchevykh produktov v profllaktlke saturnisms. fThe possibility of using local pectin-containing mod products for the prophylaxis of lead poisoning.; TR PERM MED INST J3- 194-199. 1976.'Translated from REF Z 1 OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKS1KOL, 1970. No. 10.54.589.--For 4 mo. lead acetate at SO mp/kg was fed fntragastrlcailv to 2-mo.-old male rats. Those of group 1 were maintained on the usual ration and those of group 2 were given the usual ration - SOT raw carrots. Dv the end of the exposure to Pb, the rats of group 1 had developed the symptoms of chronic Pb poisoning: torpor, disturbances ol nutrition, loss of hair and a re duction In food consumption. During the entire period of observation all the rats of group 2 remained well, gained weight and had a good appetite. In rats of group 2 the dally diuresis was 9-11 ml. On the 20th-25th day of exposure those of group 1 showed hypourla (3-4 ml). The average weight at the end of the experiment was 154.1 g for group 1 and 192 g for group 2. The kidneys and gastrointestinal tract of L^^ththeerrats of group 2 excreted 97.5 mg Pb (65" of that taken Into the body) ats of group l, 60 mg (40T.1. The prophylactic action ot local 1-Containing food product.' should be studied for use in the thera- lc-prophylactic diet ol workers exposed to Pb.--6. T. 122290. LOSKUTOV, N. F,, and N. F. SHUSTVAL'. Izmenenie elektrokardlogrammy pod vliyantom krotononttrlla 1 tzokrotono-nltrlt*. [Changes In the electrocardiogram under the action of crotononitrlle and isocrotononitrile.l TR KHAfVKOV MED iNST 13^-139. 1969. Translated from REF ZH OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKSKOL, 1970, No. 0 54.635.--In rats and guinea pigs given a single median lethal dose of crotononitrile (1) or tsocrotono- nitrtle (II; used In the production of synthetic rubber), the ECO shovmd a reduction in the voltage of the QRS complex, an increase In the num ber of heartbeats to 600/mln, an upward shift from the baseline of segment ST, and the appearance of a high, pointed T wave (for 3-4 days). In subacute experiments f was given tntragastrtcally to rats at 100 and 50 mg/kg and n at 17 and 34 mg/kg for 1.5 mo. Guinea pigs sere given an aqueous solution ol 27 or 55 mg/kg of I to drink lor 2.5 mo. The rats showed an Increase In the heart rale, upward displace ment of the ST segment from the baseline, an increase In the T2-3 wave to 7-8 mm, a reduction In the QRS voltage, an Increase in the PQ Interval, and, In Some of the animals, stnoaurlcular blockade or blockade of the left branch of the bundle of Hls. Changes of this type were also found In guinea pigs. Impairment of the principal functions of the myocardium occurs; the conductivity, excitability, automatism, and contractility, this Is explained by Impairment ot the metabolic processes in the myocardium caused by the poisoning. There Is A bib liography with 10 references. From the Ukrainian Institute tor the Poetgraduaie Education of Doctors, Khar'kov, US5R.--6, T. '27291 nASALAEV, A. V. (Gorki li*t. Ind. Hyg. Oceup.Dls., Gorki, ,S5R.) Opyt primonemva krupnokadrovol flyuorografll prl ossiedo- Isnli skclcta u rabotavushchlkh v kontakte s ncpredcl'nyml uglevodoraml ettlenogo ryada (oleflnaml) 1 ikh khlorprotzvodnyml (khlorvlnlL trlkhloretilen). fExprrlrnr* with the use of large-frame photoliuorography In examining skrirtxl ;*>ni ni persons occupaiIonativ dealing w'lh unsaturated hydrocarbons of the Mhylene series (nleinis) and ineir chlorine derivaiives tyinvl ehtoriie, trlcnlorelhvlenel.) GIG TR PROF 7L 14(11); 51-37. 1070. (FngL sum.[-These examinations re* -d a definite reconstruetIon In the bones; osteosclerosis, oeteo_ o*U, oeteolvsu and cystic changes. Traumatization ol the limb* add prevalence In the clinical poisoning picture of these symptoms 1110% |No*. 1, IB""! TC suggeated lesions of higher vegetative centers, particularly of the hypnthalamlc region. These changes may Is- of a wurorlvsirophlc nature, , Large -frame pftotoflunrngraphy may he recommended foe rnentgrnologi cal examination* ol the skeleton In occupational gro"ps with jntential hone pathology.--C. M. M. 122292. AMIROV, R. 0., I. I. ALEKPEROV, and V. D. PIVOVAROV. K anitarno-clglcnlcheskol kharalaerlstlke uslovll truda ralmtavushehik prl pohiehenll kataplna (lKIKhP-2). [A sanitary-hvgtenic e.haranerltaHon of the working conditions of persons producing kafapin UKfKhP -?) l-tP^odceyllwnr.yl)-pyTtd\nlum.[ TR AZKRn NAUCII-1S5LF.D INST GIG TR PROF /.AflOL 3. 134-143. 1969. From; REF ZM OTD VYP FARMAKOL KHIMIOTER SREDSTVA TOKS1KOL. 1970, No. 1,54.1319. 122293. BRAKHINOVA, I. T,, and G. V. SAMSONOV. Sravnltel'naya otsenka vtlyanlya na organism nttrldov perekhodnykh metallov 1 nemetallov. [Comparative study of the effect of transittonal metal and nonmetallic nitrides on the bodv.l GIG TR PR<6f zAh6l l4f 12); ^8-50. 1676(recd. 1971|.--In experiment* with white rats nitrides of nonmetals Including BN, SI3N4, and BNC had weakly pronounced ttbrogentc activity and caused pneumoconlottc changes. Metal-like nitrides Including TIN, ZrN and NbN In addition caused dystrophy of the liver and epithelium ot the renal convoluted tubules. The recommended maximum permissible dose tor nitrides of non-metals and NbN ts 10 mg/ml, for AIN Is 4 mg/m^ and for ZrN 1* 5 mg/m3. The toxic ef fect* of nitrides corresponded to their electron structure. Their biological activity decreased with the Increased possibility of forming S2p-efectron configurations during interaction with N of non-metals and semi-metals and also dS -configurations with the formation of nitrides of transitional metals.--N. L. G. _____... ___________ ..., (yv.vvw.WMWMi;* WSVVKTWUJA (UJUII H khlopkorobov, vyzvannye yadokhtmikatami, i meropriyatiya po ikh profllaktlke. [Occupational skin diseases in cotton growers caused by chemical poisons and measures for their prevention.! GIG TR PROF zAb6l 14(12): 55-5}. 19'[0(rec_d. l9ll]. --Dermatitis and eczema occurred In 30 persona out of 32 In direct contact with DDT and hexa- chiorane. The disturbances.were of a seasonal nature. Of 633 cotton growers, the akin was sensitive to the phosphoorgantc Insecticides methylmercaptophos, octamethyl and butyphos in 42'7, The time of development of sensitization to different chemicals varied and depended on body response, concentration ot the chemical, work conditions and the nature of contact,--N. L. G. 122295. AN, A. S., V. A. D'YACHENKO. V. I. IVANOV, and A. P. TALIN. Opyt medilramentoznoi profilaktlkt pora2henil nervnol alsterey prl lntokstkatsli ognestolklm maslom "Iwlol -3". [Experience in medical prevention ot Injury to the nervous system In potsoninc with the tireprooT oil 'Tvio`l`"'M GIG TR PROF ab5L" 14]IS); 37-3g,~ 1970frecd. 1971J.--persons working without gas mask* In the remains of a breakdown at an electric power station were intoxicated by the fumes of "Ivlol-3", a compound based on trtxylenylphosphate, vitamin E, vitamin Bg and phytln was effective in preventing damage to the nervous system.--N. L. G. 122296. EUSUISKAYA, R. V. SoStoyanle plodovitosti u zhtTotnykh prl khrooicheskom vozdeistvll parov metadizopropllbenaola. [Condition of fecundity In animals subjected to chronic effects of metadnsoorppyItaenzene lume*. I GIG TR PR&F ZAB6L l4(l2): 4i-46. i970[recd. 1971 [,--White rats (45) with strictly periodic oextral cycles were ex posed to the fumes of metadlisopropylhenzene In concentrations of 0.2 mg/1 and 1 mgA 5 hr daily 5 times a wk for 5 mo. The course of the sexual cycle was disturbed with chsracteristic prolonged flow. The capacity for conception was substantially decreased. The average number of offspring decreased as well as their weight. Gonadotropic, effects of the compound are indicated. Women'a work In the presence of this compound should be regulated.--N. L. G. ___ .. _ . I IT* af Ml u, vn Ibii bin, etna All. VOROTNIKOVA. (Novosib. Sanit. Inst., Novostb., USSR.) Opyt pri- mencnlya -amlnokapronovoi klsloty prl khronlchesknl lntokstkatsli benaolom 1 ego gomoiogaml. (Experience using `-amtnncapronlc acid In chronic poisoning with benzene and Its homoiogues.l GIG TR Pr6f WB&L nri:..TWrT9TO[?ed.T57ll. "A mmocapronlc arid. vitamins Bg and Bi2, glucose and Fe preparations were used to treat 13 patients with chronic poisoning by benzene and its homologues with symptoms of hemorrhagic diathesis. A hemostatic effect was obtained in 12-daya In patients wtth mild symptoms of hemophilia and in 2-3 day days In those with pronounced manifestations of diathesis. In addition to the hemostatic effect, capillary permeability and the ttbrlnolvuc activity of the blood decreased and blood coagulation time speeded op. The number of mature platelets Increased alter treatment and the num ber of old thrombocyte form* increased.--N. L. C. ______ _ . , ... ,,, 1.j,,. .u*itui. rvnx. t-oiym. rust, Subet., Kler, USSR.) Oboenovante predel'no dopustimoi kontsemratstl Fotalona v vpzdukhe rabochel zony. [Substarglatlon of the maximum permissible concentration of Fotalon In the air of a production area. SetTOftoFiABtiL uuasrdwi:^WTOfreis: BOR 009733