Document ypYVXG2J61JgapEeqwexvzggr

VK the relationship of atement is made in and well worth reuency in which the even the patients.'' ; often if the quesasbestos, was more lich a worker might : minerals often re;ts of these mineral rces are located in iuth Africa, and the er and then the long .-esses that the most he manufacture of aper, heat resistant :reasingly found in g developed. In the individual had been ned with the use of e been the possible to saw through this ;-containing dust, here seems to be a if carcinoma that is that squamous cell ;nocarcinoma is the pulmonary cancers These are generally , as for instance the ier carcinoma arises 3 remains to be de: that the squamous sbestos fibers might aogens, and by this would be important ilmonary carcinoma ,ry carcinoma in ini-20%. Statistically, i of the pleura that t - from Liverpool, consecutive cases of lg tissue in ten of \ it ,5. ;. i .. C. /{ | ;; | ASBESTOSIS & CARCINOMA--DUTRA & CARNEY 423 is suggested that thick frozen sections be used because asbestosis bodies may easily be missed in thin sections.3 Fibrosis of the pleura with adhesions to surrounding struc tures is commonplace in asbestosis. The asbestosis bodies produce alterations in the periphery of the lung whereby these bodies gain entrance to the pleural tissues via the peripheral lymphatics in the lung'. Because of the occurrence of mesothelioma in association with asbestosis, it is likely that substances in asbestos fibers are spe cifically carcinogenic. It is unlikely that other inhaled carcinogens would gain access to the pleura and produce carcinoma in tissue previously rendered less resistant by the asbestos. A case of asbestosis in which the individual had both bronchogenic and gastric carcinomas and in which the latter tumor contained refractile granules lends support to this concept of the specific carcinogenicity of the asbestos fibers. REFERENCES 1. Spencer, H.: Pathology ot Lung, New York: The Macmillan Co., 1962, pp 618-619. 2. Owen, W. G.: Diffuse Mesothelioma and Asbestos Exposure in Merseyside Brit Med T 2:214, 1964. 3. Fowler, P. B. S.; Sloper, J. S.; and Warner, F. C.: Exposure to Asbestos and Mesothelioma of Pleura, Brit Med J 2:211, 1964.