Document ypVwR5BBoNyOEkJBzEMJpxn3n

STUDIES OF MINERAL CONTENT AND PARTICLE SIZE DISTRIBUTION IN THE LUNGS OF A 03 09 7 ASBESTOS TEXTILE WORKERS J. Beattie and J. F. Knox Queens' College, Cambridge and Turner Brothers Asbestos Co. Ltd., Rochdale, Lancs. / Abstract--The mineral content of the lung parenchyma, the lung hilar region, and the pleural tissues has been determined in lungs from SO workers in the asbestos textile industry. Of these, 27 cases have been reported previously and the results in 23 new cases are now added to the series. The exposure time varied from 3 months to 46 years and the time interval from last exposure to death was from less than one year to 25 years. With lengthened exposure time there was an increase in the mineral content though there was considerable variability in individual cases. The severity of the asbestotic lesion found at autopsy was not related to the mineral content but to the sum or the exposure and survival time. The particle size distribution of the incombustible and acid insoluble residues in the lung of these cases was also determined. The number of particles with lengths in excess of 36 n was considerable up to the end of the eighth year since last exposure and later fell. -'-'"`In cases of severe asbestosis there was a significant fall in the number of fibres exceeding 15ri in length. The number of fibres, whose length was less than I5p increased in cases of moderate and severe asbestosis. It is considered that these findings point to the liberation of a fibrogenic agent from the break down of asbestosis bodies under conditions unfavourable to its disposal. In 1954 we reported the results of a study oflung material from 27 subjects who had been exposed to asbestos dust in the asbestos textile industry for varying periods of time. The present paper records the results obtained on a further group of 23 subjects who had worked in the same factory. The purpose of the studies was to determine (1) the relation of the mineral content of the lungs of persons exposed to asbestos dust to the development of the fibrotic condition of the lungs known as asbestosis, (2) the lengths of the asbestos fibres which had been retained in the lungs. We have included the detailed findings of the first group of 27 subjects which we have recorded already (Knox and Beattie, 1954) with the details of the latter group of 23 subjects in our several tables. The discussion of the results therefore is based on the full group of 50. We studied lungs from a small group of subjects who had never been exposed to asbestos dust but had lived most of their lives in the same industrial area as the main group. STUDIES OF MINERAL CONTENT AND PARTICLE SIZE DISTRIBUTION IN THE LUNGS OF , . A03097 ASBESTOS TEXTILE WORKERS k < J. Beattie and J. F. Knox Queens' College, Cambridge and Turner Brothers Asbestos Co. Ltd., Rochdale, Lancs. Abstract--The mineral content . of the . lung parenchyma, the. lung hilar region, and . the pleural tissues .has been determined in lungs from SO workers in the asbestos textile industry. Of these, 27 cases have been reported previously and the results in 23 new cases are now added to the series.' '";V' *,. , * The exposure time varied from 3 months to 46 years and the time interval from last exposure to death was from less than one year to 23 years. With lengthened exposure - time there was an increase in the mineral content though there a-as considerable variability in individual cases. |; v'.- The severity of the asbestotic lesion found at;-autopsy was not related to.the mineral content but to the sum of.the exposure and surfival time.i The particle size distribution of the incombustible and acid insoluble residues in the lung of these cases was also determined. . s'* J M, / y . . ; ^ The number of particles with lengths iti excess of 36 p was considerable; up totheend of the eighth year since last exposure .and later fell;. ;c` v ' '1 ---^1n cases of severe asbestosis there was a significant fall in the number of fibres exceeding 13ft in length. The number of fibres, whose length was less than I5ju increased in cases of moderate and severe asbestosis. ` ^ .*/. ; j ,f-'\ It is considered that these findings point td the liberation of a fibrogenic agent from the break down of asbestosis bodies under coriditions unfavourable to its disposal. In 1954 we reported the results of'a study of lung material from 27 subjects who had been exposed to asbestos dust in the asbestos textile industry for varying periods of time. The present paper records the results obtained on a further group of 23 subjects who had worked in the same factory. The purpose of the studies was to determine (!) the relation of the mineral content of the lungs of persons exposed to asbestos dust to the development of the fibrotic condition of the lungs known as asbestosis, (2) the lengths of the asbestos fibres-which had been retained, in the lungs. We have included the detailed findings of tbe first group of 27 subjects which we have recorded already (Knox and Beattie, 1954) with the details of the latter group of 23. subjects in our several tables. The discussion of the results.therefore is based on the full group of 50. We studied lungs from a small group of subjects who had never been exposed to asbestos dust but had lived most of their lives .in the same industrial area as the main group. j X----------------------------------------------------------- --- "^ "r'_ r--rT