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OSHA issues tentative carcinogen list The Occupational Safety & Health Ad ministration earlier this month issued a tentative list of chemicals that may be regulated under ita proposed generic carcinogen policy. The policy, published in the Oct 4, 1977, Federal Register, would classify chemicals into one of four categories based on the substance's known or suspected carcinogenicity. Classification into Categories 1 and II would trigger regulatory action based on model standards in the proposal. In its proposal, OSHA recognized that implementation would require developing a system of priorities for the orderly handling of a large number of substances for which there is some evidence of car cinogenicity. The agency noted that the National Institute for Occupational Safety & Health has identified more than 2000 substances for which there is alleg edly some degree of evidence of turaorigenicity or carcinogenicity. To get an idea of how many substances might fall into each of it* proposed categories, OSHA contracted with Clement Associates Inc., a Washington, D.C., consulting firm, for a preliminary review and categorization of the chemicals identified in NIOSH's 1976 inventory of "suspected carcino gens" Clement's first task was to identify those chemicals listed by NIOSH that are found in U.S. workplaces. It used two sources of information to accomplish this task. The first was the Environmental Protection Agency's candidate list, a first pass at identifying chemicals produced commercially in the U.S. for regulation under the Toxic Substances Control Act. The second source was the International Trade Commission's 1976 data base on organic chemicals produced commercially in the U.S. Comparing the chemicals obtained from these two sources against the NIOSH inventory ehowed that, baaed on the EPA candidate list, 269 chemicals would be placed in OSHA's Category I, which would list confirmed carcinogens based on human data, or based on testa in two mammalian species or in one speciee if ths tests have been replicated. An ad ditional 216 chemicals would be placed in Category II, comprised of substances whose carcinogenicity has been reported but for which the evidence is only sug gestive or is positive in only one species and not yet replicated. And 396 sub stances would be placed in Category III, which is made up of substances with no, or at most meager, evidence of carcino genic risk. Based on 1TC data. 116 chem icals would be placed in Category 1,72 in Category II, and 181 in Category III. It is these 116 Category 1 chemicals, according to OSHA, that would be the most proba ble candidates for regulation. In compiling tha list Clement Asso ciates said that if in reviewing each chemical it came across two positive re ports of carcinogenic or neoplastic effects, it went no further. It also did not take negative studies into account and there was no attempt to factor in whatever data might exist as the result of short-term testing. Thus, OSHA emphasizes that the list is only tentative. It points out that, based on further scientific scrutiny, some chemicals may be dropped from the Ust, others may be added based on new evi dence, or the criteria used to determine lacement in the various categories may e changed in the final carcinogen policy regulation. Candidates for addition to the list in clude imported chemicals that are present in U.S. workplaces and those that are produced as by-products of combustion and other processes. Under the proposed policy once a sub stance is placed in Category 1 it can be removed from the list only If the Secretary of Labor determines: that the alleged carcinogenic risk based on animal data clearly resulted from nonspecific physical, rather than chemical induction; that the route of exposure was grossly inappro priate relative to the potential occupa tional routes of human exposure; that the human or animal studiaf submitted for review are only suggntive; that the human or animal studies are totally in adequate to establish any conclusion with respect to the carcinogenicity or noncar cinogenicity of the toxic substance; or that, for some other scientific reason, the positive results in experimental animals are not relevant to man. The potentially far-reaching implica tions of a Category I classification include almost automatic issuance of Emergency Temporary Standards and, within six months, permanent standards reducing employee exposure to such substances to th* lowest feasible level through the uee of engineering controls and the imposition of workplace monitoring and employee medical surveillance requirements. Some industry observers fear that because there is no exclusion in the propoeed cancer policy for contaminants present in trace quantities, commercial products that contain only traces of Category I sub stances might have to be regulated and handled as confirmed carcinogens. Fol lowing is the complete list of substances in Category I. CATEGORY I Acetamide* Aoetamkle, N-fluoren-2-yi- Aoetamkle, N,N'-fluoren-2,7-yleneble- Acetamide, W-|4!5-nKro*2-luranyl)-2thtazolyl]- Aoetamkle, W-2-phenanthyrenyl- Aoetanilkte, 4'-phenyl- Acetanilide, 4'-styryl- Aoetlc eck), chromlum(8+) salt* AoeUc acid, diazo-, ethyl ester Aottic sold, lead(2+) salt* Aoetohydroxamlc acid, N-tluoren-2-yi- Acetohydroxamlc acid. N-fluoren-3-ylAfiatoxln 82 Afiatoxln Q1 Alanine, 4-{bls<2-ehloroethyl)amino]phenyi-, L* Alanine, 4-|bie(2-hloroethyl)amino]phenyl-l DL* Ailylamine, Mmethyi-Moltroeo- Ammonium. (4-(p4lmfthylamlno)-<Mp(ethyl(m-euHoOenzyOamlno)Dhenyl)benzylldene-2,5-cyctohexadlen-1 -yddene)elhyK m- sullobenzylK hydroxide, inner salt, sodium ear Aniline, N,NkHmethyl-4-!phenylaxoV-* Aniline. 4,4'-<imidocart>onyl)bli(N.AWImethyH* Aniline. 4.4'-(lmidocart>onyl)bie<W,dimethyl-. hydrochloride" Aniline. AAmethyl-4-(phenylexoK Aniline, N-methyl-N-nltroeoAniline, 4,4'-methyien#bl(2-methyl]- Anlllne, /Mphenylazo)-* - o-Anlekllne. 4-(phenylszo)- Arsenic* Arsenic acid, calcium eall|2;3)" Arsenic acid. Iead(2+)ealt(1:ir Arsenic trioxide* Arsenic acid, potassium salt" Asbestos* IH-Azeplne. hexehydro-1 -nttroeo- Azirino[2r,3':3,4]pyrrolo[1.2-a]lndolt*4.7dlone, 6-amb)o-6-( ((aminocarbonyl) oxyl]methyl)-1,1e,2,6.8a,8b-hexahyOro8a-methoxy-5-methyl, carbamatefester) Azoclne, octahydro-1-nltroeo- Barblturlc acid, 5-ethyl-S-phenyl-, monosodium salt* Benz[ ejacepbenanthrytene Benzjajanthraoene Benzjajenthracene, 7,12-dlmethyl-* Benzjjjanthracene, 7-methylBenzlajanthracene. 7,6,12.trlmethyt- Benzenamlne. N,N'-dlmethyl-4-[(3methylphenyl)azoj- Benzenamkte, 4,4'-methylenetols(2-chioro-* Benzene* Benzene, 4-allyl-1,2-(methylenedtoxy>-* Benzene, 1.2-methyienedtoxy-A-propyl-* Benzidine* Benzidine. 3.3'^Mchlor-* Benzidine, 3,3'Htlmethoxy* Benzidine. 3,3'-dlme*xy, dthydroehlortdeBenzkline. sulfate! 1:1)* 1.2-Beruleothlazol-3(2H)-one. 1.1-dkwkle* 1^-Benzlsothlezd-3(2M>-one, l.l-dloxide, sodium ear Benzol rst]pentaphene Benzo[c)phenanthrene. 5-methylBenzo[ a)pyrene p-Benzoquktone. 2.3.5-trlsO-azirtdtnylK Benzo [ b] trtpheny lane Benzyiamlne, N-methyl-A^nHroeoBertrandite* Beryl* Beryllium* Beryllium fluoride Beryllium hydrogen phosphate! 1:1 f Beryllium oxide* Beryllium sulfate! 1:1)* Beryllium sulfate tetrahydrate(1:1:4)* 4-Biphenytamlne tO CAEN July 31, 1979 HONS 000682 I: 4-Blphenylamlne, 2',3-dlmethylBiphenyl, 4*nKro Biuret. N*thyl-N-nltroeoBlurel, N-methyl-W-nltrose1-dulnamlr>, M^utyUN-nltrosoButane, 1,2:3,4-dlepoxyButane, (+--)-1,2:3,4-dlepoxyButane. 1,2:3,4-dlepoxy-, meso 5H,8H-S,5a,l3a.14-<1,2,3,4)-Butanetetrayley- cloocta(1,2*b:5,8*b>dinaphthalene5.8.13.18( 14HMatrone. 1,4,2,0,12,15,17.20-octahydroxy-3,11-cM> methyl1- Bulanol, 4-{butylnltrosamlno)Butylamlne, N-ethyl-N-nltroso* Butylamlne, W-methyl-N-nltrosoButyrlo add. 2-mir>o-4-4ethylthlo)-1i-Butyrlc acid, 2-amlno-4-(ethylthlo)-.oiButyric acid, 4-lp*bls(2-chloroethyl)amlnophanyl]-* Cadmium* Cadmium. bl(diathyk)lthk>carbamaio)-* Cadmium chloride* Cadmium oxide* Cadmium sulfate{1:1)* Cadmium sulfide* Carbamlc aoid. bls(2-hydroxyethyl)dlthlo-, monopolatsium salt Carbamlc acid, ethyl ester* Carbamlo aold. N-methyl-N-nltroso-, ethyl ester Carbon tetrachloride* Chloroform* Cholanthrene, 3-methyl-* Chromic acid, calchim salt(l:ip Chromic acid, calcium sall< 1:1), dlhydrate* Chromic acid, ohromlum(3+> salt{3:2)* Chromic acid, dipotasslum sail* Chromic add, dlsodlum salt* Chromlo aold, leed(2+> salt(l:1)* Chromite* Chromium* Chromlum(VI) oxlde(1:3)* Chromlum(lll) oxlde(2:3)* 6*Chrysenamlnd . Coumarln* Cyclohexane. 1,2,3,4,5.6-hexachloroCyelohexane. 1.2.3,4,5,8-hexachloro-, alpha Isomer Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma Isomer* Cydohexane, 1,2,3,4,5,6-hexachloro-, (mixed Isomer) Cydohexanecarbemlc add. 1.1-dlphenyl-2- propynyl ester Cyclopentai e)furo|3\2':4.5]furo|2.3-h] | f) benzopyran-1,11-done,2.3.6a.9a-tetrahydro-4-methoxy- Daunomycln D)bant|a,h]acrldlne Dlbenz|a.y|acrWlne Dlbentja,h)anthracene 7H-Olbenzo| c.g]carbazole Dlbenzo(b.def) chrysene 2- Olbencofuranamlne dOlbencofuranamlne, 2-methoxyH*Dlbenzo|6,d)pyran-$-one, 2-aoetamldo- Diohromlc acid, dlsodlum salt* Olethylamlne, 2,2'-dlchloro-N-m#thyl* Dlethylamlne, 2,2'-dichloro-W-methyl-, hydrochloride Olethylamlne, 2,2'-dlchloro-N-methyl-, Noxide Olethylamlne, 2,2'Hllcbloro-/V-methyl-, Noxide, hydrochloride Dlethylamlne. N-nltroso1,4:5,8-Dlmethanonephthalene, 1,2,3,4.10.10-hexachloro-6.7-epoxy* 1,4,4a,5,6,7,B.Sa-octehydro-, endo, exo>* Dimethylamine, N-nltroso-* p-Oloxane* Estra-1,3.5,7,9-pentaen-17-one, 3-hydroxyEstra-1,3.5(10),7-tetraen-17-one, 3-hydroxyEslradlol 17-a-Estradiol Estradiol, 3-benzoate Estradiol, dipropionate Estriol Estrone Estrone benzoate Ethane, azo Ethane. azoxyEthane, 1.2-dibromo-* Ethane. 1.1,1-trlchloro-2,2-bls(p- chlorophenyl)-* Ether, bla(chk>romethyl) Ethylene, chloro-, monomer* Ethylenediemine, N,N'-dimethyl-N,N- dlnltrosoEthylene, 1,l4Hchloro-2,2-bls(p-chloropher>yl^ Ethylene, trlchloro-* Ethylenlmlne* Fluoren-2-amlne Fluorene-2.7-dlamlne Formamlde, N-|4-(5-nl1ro*2-furanyl)-2* thlazolyl]-* Formic acid, 2-[4-<5*nitro-2-furanyl)-2- thlazolyl]-, hydrazlde 7H-furo(3',2':4,5]turo[2,3*c]xanthen-7-one, 3a, 12c-dlhydro*8-hydroxy-6-methoxy- Qlucopyranose. 2-deoxy-2-<3-methyl-3nltrosoureWoho- /3-o-QluoopyranosWe, (methyl-CWN-azoxy)methyl Qlycldeldehyde Quanldlne, W-ethyl-V-nltro-AA-nltroso Guanidine, W-methyl-V-nitro-N-nltroso- Hematlte* Hydrazine* Hydrazine. 1-acetyl-2-plcollnoylHydrazlne, 1,2-dlethyl Hydrazine, 1,1-dlmethyl-. monohydrochloride Hydrazine, 1,2-dlmathylHydrazine, 1,2-dlmethyh hydroohlorlde Hydrazine. 1,2-dlmethyk dlhydrochlorkte Hydrazine, methyl*, sulfate Hydrazine, monohydrate Hydrazine, phenyl-, monohydrochloride* Hydrazine, sullate(1:1) lmidazole-4-cartooxamlde, 5-(3.3-dlmethyl-1trlazenyl)* Isonlootlnlc acid, hydrazlde* Laslocarplne Mesomorphic Order in Polymers and Polymerization In Liquid Crystalline Media ACS Symposium Series No. 74 Alexandre Blumetein. Editor University of Lowell A symposium sponsored the the Division of Polymer Chemistry, Inc. of the American Chemicel Society. Mesomorphic order In polymers is of prime Importance In the growing laid of nigh-strength materials aswell aato other fundamental aspects of polymer science including biophysics of macromolecules. Sixteen chapters present an extensive review of the broader aspects of this rapidly dsvelopinp area providing a valu able source of Information for polymer scientists, chemists, physicists, rheologiste, and biologists In both Industry and academia. The participation of scientists from France, Germany, Japan, Italy, Hungary, and the U.S.S.R. guarantees a well-rounded International covtraoe of the field. CONTENTS X-fty OMiaaion Sludfee on MooomerpMe Order In "-rtyimere EnanUoVepis (Uoutd Ciywilna) Petymera fnermouoplc ChotoMarot-CentaMM lipoid Cryata>... .a Potymara liquid CryateHma Ordar to Poipnera and Copofrmaia allh ghoywrW Sjdt Orw^aNdly^ ol Poly (p-BIphenyt Aonrtatt) and naSdadPslyaasra. Bulk refymsrttetton ot 4-Oyano4'4lshanyt (n MtanoaiM a Polymerization in unM Crystal* 8tata a Tha<motroptc Maaaphaao naacSona Namas. Pojymtra: Exoiuded Votuma ESaota a PotygMamatas In Ceneentreled eoMtona Maanaite naeWamatien ndCountanotalionin Poiyfo-Bentyl OMamata)liquid Ciyataia Block Copolymers from Amino Adda a BlomaaoQana: Poawbiwai of MaaomorpWc Order m PotynwcitoUda Anateguaa a Chotaatartc Ordar m BtojKgmra a Liquid CrysleMn*Contract** Appsralu* 264 pages (1978) $25.50 clothbound LC 78-9470 ISBN 0-8412-0419-5 818/Amerloan Chemical Society 1155 16th St., N.W./Wath., O.C. 20036 Plaaaaaand_________cedes otSSMAtsssmorpnic Ordar In Pofymtrt at SSS 90 par eopy. C Chat* anotoaad lor SOBNmo. Poa^aldln U.S. and Canada, pda TSasmadaewHera. Nam* Addrsaa City_______________ Mala_________Zip MQNS 000603 July 31, 1978 CAEN 21 fftf. < i' Lipids as a Source of Flavor ACS Symposium Series No. 75 Michael K. Supran, Editor Thomas J. Upton, Inc. A symposium sponsored by the Fftvor Sub`DJvl$lon ot tha Division of Agricul turaland Food Chamlatry of tho American Chamict Soolaty. This volume presents a review of the cur rent state-of-the-art by some of the most eminent researchers In the field of lipid ohemlatry as it relates to the flavor of foods. These papers will be particularly useful to food sofentfsts Involved In all aspects of research and product development of food products, chemists, engineers, and manufacturers of lipid and lipid-containing food products, CONTENTS Th* not* UpW* PUy in tha Port** and NagaW* Flavor* ot Food: V* Lnman and Seholy Numryoh CtiomiMryotOoopFatFriodFlavor: Stophon 8. Chang, Robert J. Potoiwn, and Chi-Tang ho Volawoa iron Frying Fat*: A Comparatlv* Study: W.W. Nawar. 8J. Bridloy, S.8. lomanno. Q O. Rlohardaon. and R.C. Whitman QonwationotAroma Compound*by Photo OMdauon ot unaaturatod Fatty Eatar* i Brafa o. Meokhar|aa and Robafl W. Trankla tnatmmantal Analyte ot VotaWaain Food Product*: Harold P. Dupuy. Mon* l. Brown, MiehMl 0. Ugondro. Jama* I. Wadsworth, and Edo T Raynor Chomioat Chango* Invoked in tho Oxidationot Upttt in Food*: D A. U*ard Flavor ProMomo In tho Uaago ot Soybean 01 and Meal: H.J. Pulton a flavor* Irom Upid* by Mbrobtotogioal Action: L. Wondol Haymon andJama* C. Aeton 132 pages (1976) $16.90 dothbound LC 76-0730 ISBN 0*412-0418-7 WAmnloan Chwilcil Soolaty list 16th St., N.W./WaMl., D.C. 20038 Plsass ond____ ____ eoptaa ot SS 79 U(Ml a* a Sovroo or Flavor at fi|.SO par oopy. GChoohonolooodlorlOBIImo. Postpaid in U.8. and Canada, plua 76 oont* otaowharo. Homo AddroM CHy______________#J*|*________ Lead ecetate(l1), trihydrate lead, bls(acetato.o)tetrahydroxytfl-* Lead chromat(VI) oxide* Lead naphthenate* Leadfll) phosphate(3:2F Mannitol. 1,6-bi*t(2-chk>roethyl)amlnoJ-1,6dideoxy-. o- Mannitol, 1,6-bls[(2-chloroethyl)amlno).1,6dideoxy, o, dihydrochloride Methane, diazoMethaneaulfonlc acid, ethyl ester Methanesulfonlc add, methyl ester Methanol. (melhyi-OMN-zoxyh Methanol, (methyl-ONN-azoxyhacetate (eater) 1.3.4- Metheno-1H-cydobuta{cd]perttaJene, 1,1a,2,2,3,3a,4,5,5,5a,6b,6-dodecachlocooetahydro-* 1.3.4- Metheno-2H-cyclobuta[cd]pentalen-2one, 1,1a,3,3a,4,5,5,5a.Sb.6decachlorooctahydro-* Morpholine, 4-nltroso- 2,7-Naphthalenedlsulfonlc add, 3,3'-((3,3'dlmethyM,4'-blphenyler>e>-bis(azo))bl8(5amlno-4-hydroxy-, tetraaodium salt* 2,7-Naphthalenedlsulfonlc add, 3-hydroxy-4((2,4,6*trlmethylphenyl)azo]-, dltodium salt* 2,7-Naphthalenedlsulfonlc acid, 3-hydroxy-4(2,4-xylylazoK disodlum salt* 2-Naphthoi, 1-|(2,5-dlmethoxyphenyl)azo)-* 2-Naphthol, Ho-tolylazo)-* 1- Naphthylamina* 2- Naphthylamtne* Nickel* Nlckel(ll) acetata(1:2)* Nickel, bls(dlbutyldlthlocarbamato)-* Nickel carbonyl* Nlckelocene (Nickel compound with x-cyclopentadienyl (1:2)) NIckeKli) oxide* Nickel refinery dust* Nickel sulfkte(3:2)* 19-nor-17a-Pregn-4-en-20-yn-3-one. 17- aoetyloxy19-nor17cr-Pregn-4-en-20-yn-3-one. 17- hydroxy19*nor-17a-Pregn-5(10>-efH20-yn-3-one, 17- hydroxy-* 19-nor-17a-Pregn*6(10)-en*20-yn-3-one, 17- hydroxy- mixed with 3-methoxy-19-nor17a-pregne-1,3,9(10)-trien-20-yn-i7-oi 19-nor-17a-Pregne-1,3,6( 10>-trien-20-yne-3, 17 did 17-cr-19-Norpreone-1,3,5(10)-lrlen-20-yn-17ot, 3-methoxy- 7-Oxsblcycto[4,1 ,o}heptene-3-carboxyllc add, 4-methyl-, (4-methyl-7oxabicydo(4.1.0]hept-3-yl)methyl eater 1,2-Oxathlolane 2,2-dloxlde 2H-1,3,2-Oxazaphoaphorine, 2-{bla(2- chloroethyl)emlno]tetrehydro-. 2-oxlde 2-Oxetanone* 2-Oxetanone, 4-methyl- Pentylemlne. N-methyl-W-nltrosoPhanol, 4.4'-<1,2-dlethylelhylene)dl-, meaoPhosphine sulfide, trls(1-azlrldlnylH Piperidine. 1-nltroso- Piperazine. 1.4-dlnltroaoPotychlorinated biphenyl (Kanechlor 500) Polyethylene glycol monostairate* Progesterone* Propane, 1,2-dlbromo-3-ehforo* Pyridine, 2,6-dlamlno-3-(phenylezo)-. monohydrochlorlde* Quinoline, 4-(hydroxyamlnoh 1-oxide Quinoline, 4-(hydroxyamlnoh 1-oxide, monohydrochloride Quinoline, 4-nltro-, 1-oxlde Retrorslne Sarcosine, N-nltrosoSerpentlne* Silicic add, beryllium sett Splrolbenzofuran-2{3H),l'-|2]cyclohexene)- 3,4'-dlone, 7-chloro-2',4.6-irlmethoxy-6'0-methyl4-stilbenamlne. N.N-dlmethyi*. (Eh Slllbene, a,a'-dlethyl-4,4'-dlmethoxyStllbene, 4-nltro4,4'-Stlfbenedlo(, a.or'-dlethyf-* 4,4'-Stllbenedlol. a.a'-dlethyl-, dlpropionete, (EVSulfide, bis(2-chioroethyl) Sulfonamide, 4-<ethylsulfonyl)-1-naphthelene Sulfuric add, dimethyl ester* Suifurous acid, 2-(p-lert-bulylphenoxy>-1methyJethyi*2-chk>roethyf ester* Tannic add* Tannin Testosterone Testosterone, propionate Thtazole, 2-(2,2KilmethylhylrazlnoM-(6-nlro- 2-luranyl)Thlazole, 2-hydrazlno-4-(6-nHr-2-!uranyl)Thlazole, 2-hyrazlno-4-(4-nltrophenyl)Thioacetamlde* p-Toluamlde, N-lsopropyl-a-(2- methylhydrazInoV p-Toluamlde. N-lsopropyl-n-(2- methylhydrazInoK monohydrochlorlde) o-Tolukjlne* 4-Toluldlne, cr-((p-amlnophanyl)--{4-lmlno- 2.5- cyclohexadlen-l-ylldsne))4-Toluldlne, a-[(p-ardi>ophenyl)-n44-lmlno> 2.5-cydohexedlen- i-yHdane))-, monohydrochlorlde* Trlazene, 3,3,-dimethyl-1-phenyl a-TrlanzIne, 2,4,6-trl*(1-azHdinyl) s-Trlazole, 3-amlno-* Uracil, 6-(bis(2-chloroethyl)amlno)Uracll, 6-methyl-2-thk>Uradl, 6-propyl-2-thlo-* Uracil, 2-thlo-* Urea, 1-butyl-1-nitroso urea. ethylnltroso* Urea, methylnltrosoUrea, thlo- Vlnylamlne, N-ethylN-nltroso- 2.4-Xylfdine, or(sup 4)-[(pemlnopheny0-<y(sup 4M4-lmlno-2.6-cyclohexedlen-i-ylldene))-. monohydrochlorlde* * idanUWad by Inwnational Ttadt Cemmmlow aa batog p duead eemmdretatty In U.I. CAEN July 31. 1976 HONS 000684