Document ymzo9mKo05KdQ5Gq69XO4ppME

Ground Water Guide! dioxane, FC-11, anj AEL meeting in s for carbon disulfide, chloroform, MPA will be continued at a future Final ization Chioropref^/PPD) CEG - 0,5 ppm (24-hour E t h a no 1 a "*( P P D) CEG * 0,3 ppm (24-hour TWA), Discussion Items Lead Naphthenate (FPD) (G. L, Kennedy) Lead naphthenate, used as a paint drier, has very low acute oral toxicity with an LD50 in rats of 5100 mg/kg. While no deaths occurred in rabbits administered up to B mL/kg of a 24% lead naphthenate solution* contact with the skin of man and animals shows lead naphthenate can be quickly absorbed through the skin. Workers exposed to an average lead naphthenate airborne concentration of 96 ug/m3 had a mean blood lead level of 63 ug/dL. Lead naphthenate was not mutagenic in the Ames test* Renal tumors were observed in mice dermally administered a 20% solution of lead naphthenate in benzene. When IARC reviewed this study, they noted the lack of a control group and did not classify lead naphthenate as a carcinogen. While the Committee also acknowledged the lack of a control group, the ability of other forms of lead, e.g., lead acetate, to produce kidney tumors was discussed. Our current AEL of 50 ug/nr (8-hour TWA) was continued with the addition of a skin notation. The Committee recommendation was to consider lead naphthenate a weak carcinogen in the mouse. This will be handled in a hazard determination letter on lead. Styrene (FPD) (N. D. Krivanek) StyrenFSias slight acute ora! toxici#^ with an LD50 in rats of 5utKL mg/kg. Styrene can effuse dermal irritation if the exposuhe. 1s prolonged, yfthe rabbit eye, styrene caused moderate conjunctival t/ritation. By the acute inhalation route, styrene haar slight toxicity with a four-hour LC50 in rat|Nqfj27 7:3 ppm. Repeated oral doses of styrene caused supprg^Vpd weight gain and altered organ-body weight ratio's inS^ts and effects on the blood in dogs, Gtyrene been extensively studied for its carcinogenic poten^fial by severaTN^utes of adminlstrati on, vfn most cases, thesNstudies were negative. In inhalation study conduced at Maltoni's 1aboratory* /m 1ncrease in total mammary tumors was noted in rats. Styrene is metabolized to styrene oxide which is mutagenic. Styrene was not mutagenic in the Ames test -2- N 27660 DUP040010877 [t'l Trlchiorojn uoromethane (FC-11) {H. J. Trochlmowicz) In 90-day gfvjd 18-month/!Sral studies i n rats and dogs, the lowest NOEL N^as 350 Jrtg/kg. The adverse effects observed at higher doses w&fe very slight and the weight of toxicological \yulence indicates that FC-11 has very low toxicity by a>T\routes of administration. Based on the 350 mg/kg N#EL arnd applying a 100-fold safety factor, a guideli nig^f 100'ppm was recommended 2X Agenda for December 5, 1988 AEL Meeting (Note/that this eetThg"wTTl We"at 1:0CT"p.m a. Decision Items ---------------------------- / / AsbesXts- substitute Fibers {Fibers Subcommittee) 0.2 f i be/cc 0[. 5 f i bers/cc 1 fi ber/cc 2 f i bers/cc Fiber Glass Wellastonite ChLoroprene iour TWA), ;banolamine (PPD) ppm (24- ir TWA), c. Discussion Items Lead Naphthenate (FPD) Lead naphthenate, used as a paint drier, has very low acute oral toxicity with an LD50 in rats of 5100 mg/kg. While 00 deaths occurred in rabbits administered up to 8 mL/kg of a 24% lead naphthenate solution, contact with the skin of man and animals shows lead naphthenate can be quickly absorbed through the skin. Workers exposed to an average lead naphthenate airborne concent rati on of 95 ug/nr* fAEL = 50 ug/m^) had a mean blood lead level of 63 ug/dL (AIL - 50 ug/dL), Lead naphthenate was not -.5 - DUP040010878 mutagenic in the Ames test. Renal tumors were observed in mice dermally administered a 20% solution of lead naphthenate in benzene. When IARC reviewed this study, they noted the lack of a control group and did not classify lead naphthenate as a carcinogen. FPD requests a hazard determination according to EQC guidelines. \Styrene (FPD) (N. D. Krivanek) s\yrene has slight acute oral toxicity with an LD50/n ra\s of 5000 mg/kg. Styyrr<ene can cause dermal irrlfcatlon if the exposure is extended. In the rabbit eye ,/styrene caus\d moderate conjunctival if rit a tion. By t he a cut e inhalation route, styrene has slight toxicityyiiiith a four-h\ur LC50 in rats ,of 2773 ppm. Repeated oral doses of styrene caused suppressed weight gain ajm altered organ-bo^y weight ratios in rats and effects on the blood in dogs. X^tyrene has been extensively studied for its carcinogen^ potential by several routes of administration. In most cases, these/studies were negative. Irc^an inhalation study com ducted at Mal.toni's laboratory, ark increase in total mzfmmary tumors was noted in rats. Styr&ne is metabolized Ao styrene oxide which is mutagenic. Styrene was not nfutagenic in the Ames test in this absence oX metabol i c activation. According to Russian i nvesti gatNbrs, sty rerye can cross the placenta of pregniant rats and ''decrease pne litter size and lower the viability of the p o t s * Hoyever, oral and inhalation teratology studies mvrat/ and rabbits conducted by Dow did not result in tera\o,geni c or f etotoxi c effects. Styrene also had no effect on reproduction of rats in a three!-gene rati on rep raau\ti on study. FPD has requested a hazard determi nat i o'n /^ccciVdi ng to EQC guidelines. Pi methyl form ami de </&P) (G.\L. Kennedy) Di methylformamid (DMF) was reviewed in 1986 and an updated Hazard pe termination better written. The conclusion of i s letter was rhat DMF dose not represent a unusual hazard for carcinogenrcity or developmenta1 or reproducti ve/toxi city. IARC hasVecently reviwed these same data am.J has listed DMF as aVlass 2B carcinogen, This indicates a possible carcinogenic potential for humans acaord\nq to their definitiorte. C&P has requested a revi ew /of the c yf-rent AEL and handling procedures for DMF. Monome/hylformaffM de (?CSP) (G. L. Kennedy Monomethyl f ormaim je , MM F) was reviewed in\1983 for its developmental hazard. Based on the results, of oral, der4al, and injection studies pregnant aninAXs, MMF was considered to be a devel opmental hazard. An\AEi of 2 ppm (8- and 12-hour TwA)` skin was recommended. \An -6- DUP040010879 f&T' .'/53i c. Discussion Items Styrene (FPD) (N, D, Krivanek) Styrene has slight acute oral toxicity jwith an LD50 in rats of 5000 mg/kg. Styrene can cause/dermal irritation if the exposure is extended. In the /a.bbit eye, styrene caused moderate conjunctival irritat Von. By the acute inhalation route, styrene has siighy toxicity with a four-hour LC50 in rats of 2773 ppm./ Repeated oral doses'" of styrene caused suppressed weight gain and altered organ-body weight ratios in rat's arnd effects on the blood in dogs. Styrene has been expensively studied for its carcfno'geni c potential by several routes of adnrini s'trati on. In most casefs , fthese studies were negative. In an i nhal ati on/study conducted at MaltoniVs laboratory, an increase in/Lotpl mammary tumors was noted in rats. Styrene is metabolized to styrene oxide which is mutagenic. Styrene was noyfc! mutagenic in the Ames test in the absence of metabolic activation. According to Russian investigators, s/yre'he can cross the placenta of pregnant rats and decrease /he litter size and lower the viability of the pups.j However, oral and inhalation teratology studies in frats and rabbits conducted by Dow did not result in teratog'enic or fetotoxic effects. Styrene also had no e'ffact on reproduction of rats in a three-generati on rep/oducti or, study. FPD has requested a hazard determination according to EQC guidelines. Butadiene (PD/PPD)/(S\ Pell) ........ / / , Butadiene has a 10 ppytfi AEL based on the results from a chronic inhalation s/udy in mice and an epidemiology study of eight;bupZdiene/styrene polymer plants. A nested case contjpol study of the lymphopoietic cancers found in this ,sVudy has been recently completed. PD and PPD request the current AEL be reviewed in light of this study. L e ad N a p h t h e n a t e (FPD) Lead naphthenate, used as a paint drier, has very low adute oral toxicity with an LP5Q in rats of 5100 mg/kg. White no deaths occurred in rabbits administered up to 8 mL/kg of a 24% lead naphthenate solution, contact with the skin of man and animals shows lead naphthenate can be quickly absorbed through the skin. Non-.Du Pont workers exposed to an average.,!ead naphthenate airborne con centration of 96 ug/m" (AEL *'50 ug/nr) Had a mean blood lead level of 63 ug/dL (AEL = 50 ug/dL), Lead naphthenate was not mutagenic in the Ames test. Renal tumors were observed in mice dermally administered a 20% solution pf lead naphthenate in benzene. When IARC reviwed this study, they noted the lack of a control group and did not classify lead naphthenate as a carcinogen, FPD requests a hazard determination according to EQC guidelines. DUP04001G880