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MR rae - 3220 402 | | | --- --_ ARaz - 3220 Duwreonsw0 TRADE SECRET Study Tite H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats `with One-Generation Reproduction Evaluations Volume 2f 5 Laboratory Project ID: DuPont-5990 "TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) ---~ AUTHOR: Susan A.MacKenzie, V.M.D., PhD, D.AB.T. STUDY COMPLETED ON: January 18, 2002 PERFORMING LABORATORY: EL du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. 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Doe ct tiTGGB 9H0--2D47a6y8G:avSaugbecShrtoundiyciTnoRxaitcsitwyithOne-GenerationReproductionEvaluations DuPont-5990 TABLE 48 MEAN BODY WEIGHTSAND MEAN BODY WEIGHT GAINS OF P, MALERATS Grove (mgD/OkSgE/.day) N TEST AY 78a 91 9% 1-0 o 1-0 25 v-o 100 20 20 20 5565821.79((65191.97))a 558903..17((6666..89)) MEAN BODY WEIGHT (grams) S57600..96((5593..06)) 568075..35((6624..59)) 553107..85((3301..35))%% 554537..53((3310..13))** vir-o 500 1 447622..43((5429..36))** 449802..07((5570..96))** Grove DOSE. 1-0 o 11-0 25 v-0 100 vii-o 500 . (mg/kgN/day) 20 20 20 18 est DAYS MEAN BODY WEIGHT GAIN (grams) 7-88 15.88.3)a 10302.0) 13.308.7) 10.17.7) 84-91 91-98 1134.07(36..98)) 1168..430006..9)) 131.2.87((66..44)) 107..34(062.10.)1) 77-98 40.815.2) 44.9014.5) 39.806.3) a Standard deviation is reported in parentheses. 27.8(22.4)% * Stetsattis(pti<cal0.l0y5)significant difference from control by Jonckheere-Terpstra --- CompanySanitzed. Doesnotcontain TSCACBI H-24768:Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 49 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Py FEMALE RATS DURING GESTATION Group (ngD/OkgSEday) N GEDSATAYTION o 147 2 mo w-0 25 vi-0 100 16 1 u 309.5(30.50a 338737..29((2257..92)) 466.3(29.0) MEAN BODY WEIGHT (grams) 299.2(14.5) 3336231.190(22000.38)) 445.3(32.4) 239215..21((1210..61))* 356.4(18.9)* 444.8(35.0) vi11-o 500 12 321804..31((2265..87))%% 336.8(32.5)% 396.8(53.1)* Grour DOSE 11-0 w-0 25 vi-o virz-o 100 500 --_ (mg/kNg/day) 16 un n 2 GESTATION avs MEAN BODY WEIGHT GAIN (grams) 0-7 7-14 33.7012.1a 3308.2) 3814.8) 3.87.8) 33.9012.) 26.2(10.3)% 31.3(10.1)+ 26.5(11.7)* 1-21 88.5(17.0) 81.4(16.0) 88.4(21.0) 60.0(24.3)* 0-21 156.8(24.4) 146.1024.3) 153.6(27.8) a Standard deviation is reported in parentheses. 112.7037.7)+ "sttaetsitst(ip c<al0l.y05)significant difference from control by Jonckheere-Terpstra = Company Sanitized. Does not contain TSCA Cal 9H0--2D47a6y8G:avSaugbechSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 50 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Py FEMALERATS DURING LACTATION Grove. (mgD/oksgE/.day) N LACTAAYT.ION 7 1a 21 1-0 o 3354990.610(22441.31))8.5 338502..19((2237..58)) 1-0 25 vi-o 100 un u MEAN BODY WEIGHT (grams) 334563.700(22390.04))C 364.7018.2) 342.127.1) 333278..3300719..67))% 354.9(22.2)0+ 3s0.106.3) virz-o 500 12 331216..30((3289..76))*d 330.4(11.3)e+ 333.705.008 GDorsoev.e 1-o 0 w2-50 v1i0-0o viii-o 500 - (mg/kgN/day) 4 nu un 12 LDACATYASTION MEAN BODY WEIGHT GAIN (grams) 70--174 2100..66(50.25.)80a5 11120.0131001090 199a.p60s7..62)er -01.73.092003..5160d0 war 27.2078) S22.6025.9) asa.sier 3.33.7) 0-21 3.920.000 20.2038.00C 25.7(23.) aboSnteandta6rd deviation is reported in parentheses oaNw-= 10 en-a. 30.5014.0)e * sttesattis(tpi<cal0l.0y5)s.ignificant differences from control by Jonckheere-Terpstra Ex CompanySanitized. Does not containTSCACBI H9-02-4D7a6y8G:aSvuabgcehSrtoundiyciTnoxRiactistwyithOne-GeneratonReproduction Evaluations DuPont-5990 TABL5E1 MEAN DAILY FOOD CONSUMPTION AND MEAN FOOD EFFICIENCY OF Py FEMALE RATS DURING GESTATION DGOroSvEe 1- 0 (ng/kng day) 16 w2-50 1v0i-0o vi5r0i0-o u u 12 GESTATION DAYS MEAN DATLY FOOD CONSUMPTION (grams) 0-7 7-18 25.22.38 20.0(5.5) 2720219) 27.5319) 2206..536.2071)) 22631.64003.73)) 14-21 2230305) 27.827) 27.9(7.6) 27.7(5.0) 0-21 26.6(2.0) 26.403.2) 26.3(3.9) 2 Standard deviation is reported in parentheses. 25.903.5) TheJroencwkahseenroe-sTteartpissttriacaltlesytsi(gpni<fi0c.0a5n)t. trend in food consumption by Grove 1-0 (mDgO/kSgE/.day) o 16 w-0 vi-o virz-o 25 100 500 1n 1n 12 GesDTAAYTSION (grans weiMgEhAtN gFaOiOnD/gErFaFmIsCIfEoNoCdY consuned) 0-7 0.188(.066)a 0.210(.089) 0.194(.050) 0.158(.053) 7-14 01183(1022) 0.166(.036) 0.170(.050) 0.140(.061) 1-21 0.473(.122) 0.420(.076) 0.559.504) 0.311(.149) 0-21 0.282(.062) 0.266(.047) 0.282(.057) a Standard deviation is reported in parentheses. 0.206(.066)* + SOntea-tWiasytiAcnaalllyysissignoiffiVcaarnitancdeiff(epre<nc0e.05f)r.om control in food efficiency by 396 Company Sanitized. Doesnotcontain TSCA CBI 9H0-2-4D7a6y8;GaSvubacgherSotnuidcy TinoxRiactistwyithOne-Generation Reproduction Evaluations DuPont-5990 TABLE 52 SUMMARY OF CLINICAL OBSERVATIONS IN P; RATS Py MALE RATS Grove u1m-b0er ofFIIR-a0ts withV0ObservaVtIiIo-n0 DOSE (ng/kg/day)N200 2250 10200 51080 OBSERVATIONS ADliospcehcairage Eyes) DDiisscchhaarrggee MNoosueth sSatlaiivnaetdioFnura Stained Right Eye(s) 11 10 30 03 11 0 00 00 0 5 150 0 14+ a 1 0 o Total No. of Rats with Masses 0 o 0 0 a Includes stained perineun and stained inguen. * Statistically significant trend by Cochran-Armitage test; p < 0.05 - CompanySanitized. Doesnot conTtSaCAiC8n1 H9-02-4D7a6y8:GSauvbagcehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont$990 TABLE 52 (CONTINUED) SUMMARY OF CLINICAL OBSERVATIONS IN P, RATS ?, FEMALE RATS DURING GESTATION DOSE (ng/kg/GdRaoyv)P No OBSERVATIONS ACloolpoerceidaDischarge Vaginal Opening sDailsicvhaatrigoenLeft Eye(s) SSttaaiinneedd PCeargienbeouanrd Stained Vaginal Opening NTuE-m0ber of IRVa-t0s withVIO-0bservaVtIiIoIn-0 10s 2250 11090 52000 3 5 30 71 10 o0 o0r 7o 0o 20 01 51 o o 1 DNoOteA: ThiA s table includesRIcElineicam l oe bserrvationes rfraomsaSniomarles nwiethnceopulatSioen plugs observed. Py FEMALE RATS DURING LACTATION Nurber of Rats with Given Sign - DOSE (ng/kg/GdRaoyv)e TE0-0 215-0 1V0E0O V5II0I0-0 Now 1 1 12 OBSERVATIONS ACloolpoerceidaDischarge Vaginal Opening 2 40 30 41 saDlisicvhaatrigoenLeft Eye(s) 10 0o 10 00 SSttaaiinneedd LPeefrtinBeyuen(s) 1 0o 0o 2 TotSailteN:o. MoafssRa1tsFiwristth OMbassesrevsed (2.0 cm) 11 0o 0 Shoulder Statistically significant trend by Cochran-Armitage test; p < 0.05. Too. `Company Sanitized. Doas not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 53 MEAN ESTROUS CYCLE PARAMETERS AND PRECOITAL INTERVAL INP, FEMALE RATS oPfercDeanyts oPferDcaeynst oPfercDeanyts Mean Cycle Group (ngD/oksge/.day) N Eistnrus Diiesntrus Proienstrus L(ednaygst)h PrMeecoaintal Tnterval (aays) 11-0 o 1 2 50 7 asamab 3.40.30) w-0 25 20 31 59 10 ag.eser 3.3(3.30) vi-o 100 0 3 60 6 asa vizio soo 1 2 0 10 a.sw.s600 abNS-t=a1nd6ard deviation is presented in parentheses. ca nn==i9sl. 2.82784 3.13.05) * sttesattis(tpi<cal0l.0y5)s.ignificant differences from control by Jonckheere-Terpstra --- CompanySanitized. DossnotcontTSaCAiCanl 0H.-2D4a76y8:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPout-5990 TABLE 54 SUMMARY OF SPERM PARAMETERSIN P, MALE RATS Dose (mg/kg/Gdraoyu)p 1-0 11251-0 1v0-00 vi5z00-o woTIPLeIrcTeYnt Motile Standard Deviation 52s.l8 ema 915..70010) 93.4i800) 913.l150a0) MORPPHeOrcLeOnGtY Normal Standard Deviation 9083.35010) 981..3500) 98.9 0.6010) 57.7 2.1010) EPIPDeIrDYMCAauLdaSPERM (Millions) 318.4 Standard Deviation 32.6010) 27187..850010) 20218.1120010) 22791.147000) SPetrandgarradm DCeavuidaation 118903.123100 971396.52010) 910609..20010) 1016523..11010) TESTPIoCrUTLeAsRtiSsPERWATIDS (Milli1o2n6s.)5 Standard Deviation 5.4010) 1288.168010) 192.8.52010) 1379.1090010) - vSetrangdarradm TDeesvtiiastion 843.3300) 19333.57010) a Number in group is in parentheses. 1877.400) 835..48010) * Statistically significant trend by Jonckheere-Terpstra test; p < 0.05. Tm Company Sanitized. Does not contain TSCA C81 'H-24768; Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 55 SUMMARY OF REPRODUCTIVE INDICES: P; GENERATION DOMSAETE(RmNgA/Lkg/GdRaOyU)P MATI(NNoG. IcNoDpEuXla(t8e)d/cohoused) FERT(NIoL.ITdYelIiNvDeErXed(/3c)opulated) GEST(ANToI.ONinLEgNrGoTuHp) (days) IIo-0 (1200/02.00) (1875/.2000 2(2a6.)6 v2-50 (12000/2.00) (1515/.2000 22.4 an v1I0-00 (1995/.200) 1/511.99) 22.5 ai) vI5I0I0-0 (12000/3.00) (1635/.200) 22.9 az) NUMBER per OpFreIgMnPaLnAtNTfAeTmIaOlNe SITES Standard Deviation(No.in group) 12.54.9(317) 3.1745.111) 14.8 3.37011) 107+ 4.48(14) IMPLSAtNaTnAdTaIrOdNDeEvFiFaItCiIEoNnC(YNo.(i8n)a group) _ 79.701.(014) 5.0913(.120) 7.9808(.160) 17.87.9012) a Number of pups born/mumber of implantation sites X 100 There by wCeorcehrnaon-Asrtmaittiasgteicatleslty; spig<nif0i.0c5ant trends in mating or fertility indices - Therleenwgatsh noor sitmaptliasnttiactaiolnlyefsfiignciifeinccayntbydJiofnfcekrheenecree-fTreormpsctornatrotlesti:npges<ta0t.0i5on * statistically significant trend by Jonckheere-Terpstra test; p < 0.05. ~401Company Sanitized. Doesnot conTtSaCAiCBnI H9-02-4D7a6y8G:aSvuabgcehrSonticiuTnodRxaitycistywith One-Generation Reproduction Evaluations DuPont5990 TABLE 56 MEAN PUP NUMBERS AND SURVIVAL: F GENERATION D05E8ATE(mRgA/Lka/GdRaOyU)P 11 0 2W5-0 vio 100 viz 00 ow u n 1 som Bom Alive Dbaayy PProesccuclullilnigng bay 7 Day 14 bay 21 MEAN smen oF pups/6Li3T8TER bb na eae we usp) uae 081.0 z7e9 nal0s 67530 8.0 7.9 7.7 we 60 7.9 63 aa. 6.0 7.9 sr oe Bom HE EEROFYALE PUPeS/sLeTTER eb es as Bboaryn4APlirveeculling e6sa 7re4e 6ess a3lss bay 4 Poscculling bey 7 3s a ax 32 5.8 a1 a0 2.5 Day 14 -_ vey 21 a8 pt 3s 0.5 38 a ae 0.4 Born wma nse op move pues/LTTER 238 sob 6a 5.3 bDoarynAlPirveeculling 7732a ssise 66as aples Day & Posteulling Day 7 a2 I als 31 a2 5.8 3.7 2.4 Day 14 vey 21 a2 se 2.9 0.5 a2 se 27 0.4 Sex Ratio (males) sumvIvaL(8) 0.488 0s8b 0.50 ous Gestation Indext Nean % orn Alive 01000..008 1s0e0e0d 1s0e0:0 m52s.3e 0-4 Day viability Lactation Index S168 sesh ses med 100.0 sez ae iva Litter survivals 10000 100.0 sols 2s.ome wBowoe e --- a nPeercent litters delivered having at least one live pup. FeMeaanrpercent survival from Day 4 Posteulling to Day 21 5 PSetracteinsttilciatltleyrssibgonrinfiwciatnht Statistically significant attrelnedasbty trend by oJnoencpkuhpeearlei-vTeeropnatDraay t2e1s.t; Cochran-Ammitege test; b < p 0.<050..05. _ pStraetsiesnttiecdsfowrereinpceorrfmoartmieodn oonnlyc.ombined pups per litter only. Male and female data are - `Company Saniized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont:5990 TABLE 57 ME PUPWA EIGN HTS: F, GENERATION DOSMEATE(RmNgA/LkgG/dRaOyU)P N eyo Dep & Sreuniting pay 4 posteulling 2p? Baoyy 2314 1-0 0 v2-50 1v0i-0o 17 1 1 MEAN PUP WEIGHTS (grams) 690.882 1s a. 1.5 a9 18.6 2.7) 38.03.2) 62.6 (6.3) 6.800.915 12.2 2.1) 12.3 2.1) 18.9 2.0) 73.3) 59.9 (6.0) 6.70.5) wes 0.80.00 1.96.00 ER 58.67.50 MEAN MALE PUP WEIGHTS (grams) vi5I0-0 o 12 6.200.000 sz asd 820.68 5.9 ad 35.9 (6.10 Day 0 Day 4 Preculling ~ Day 4 Posteulling Day 7 Day 14 Day 21 7.2 0.80% 11.5 (2.0) 11.8 (2.0) 10.9 2.0) 38.7 3.2) 66.2 (6.1) 210.0f 12.5 2.0) 12.6 2.1) 19.4 2.0) 38.6 3.3) 61.905.) 6.90.6 moan 11a.6 1.30. M0 EE 59.98.2 6.400.004 8.4 .5d 850.04 103 e280 ass 33.6 (5.500 MEAN FEWALE PUP WEIGHTS (grams) Day 0 6.70.08 6.60.9 Boy 4 Peseulitng 1.2 a.) 1.82.0 ay 4 Pesteviiny 11.3 as) 1.3 2.00 ey 7 ms 2m 18.6 2.0) Day 14 732 36.7 (3.2) Day 21 61.0 (6.3) 51.8057) ba oSatsandea.rd deviation is reported in parentheses. cann--110 eFunaasl 6500.5 10.5 1.3) 10.5.3) 15.4 02.8) 30 50.9 (4.60 6.0 0.004 s.0a.5d 8.0 a.5d 5.9 @.o)d 21s se 30.3 12.000 * statistically significant trends by linear contrast of least square means; p < 0.05. Nfoetmea:le dsattaatiasrteicaplreasneanltyesdesfowrerienfcoromnadtuicotnedonolny.the combined pup weights. Male and --_--_--mm CompanySanitized. Does not contTSaCAiCBnI H9-02-4D7a6y8:GSauvbagcehrSotnuidcy iTnoxRiactistywith One-Generation Reproduction Exaluations DuPont-5990 TABLE 58 SUMMARY OF PUP CLINICAL OBSERVATIONS: Fi GENERATION DOSMEATE(RmNgA/Lkg/GdRaOyU)P I10-0 2I5V-0 10VI0-0 V5I0II0-0 OBSERVATIONS LEPTARHTAIRAGLYLY CANNIBALIZED WSTEAAIRNED PERINEUM WET PERINEUM 1 o0 00 1o 00 00 00 11 o o o 1 NTOUTMABLERNUOFMBLEIRTTOEFRSSIAGNFSFECTED 11 o0 0 14 TOTAL NUMBER OF LITTERS 1 1 1 12 a nNuurmbbeerrss ionutpsaidreentthheesepsaraernethetsheesnuarmebertheofnulmibtetrersofapfufpecsteadf.fected; the pTh<ere0.w05ere no statistically significant trends by Cochran-Armitage test; - Company Sanitized. Doesnotcontain TSCA CBI 9H-02-4D7a6y8:GSauvbagcehrSonticiuTnodRxaiytcistywith One-Generation Reproduction Evaluations DuPont5990 TABLE 59 MEAN BODY WEIGHTSAND MEAN BODY WEIGHT GAINS OF Fi MALE RATS Grove (mgD/OkSgE/.day) N DAYS oN 12578 1 15 22 2369 1o1 251 v1-010 1" u 10 MEAN BODY WEIGHT (grams) 106911.240(960.67))b 213792..9401074..6)) 330634..7702251..73)) 10661..66((65..26)) 216396..77(01106..8)) 336010..78((2271..22)) 16013..15((65..10)) 212693..30((2107..21)) 239512..94((2360..27)) Grove DOSE 11 m1 25 v-1 100 (mg/kgN/day) 1m 1n 10 ~ DAYS ON E578 MEAN BODY WEIGHT GAIN (grams) 1-8 8-15 w(a.ab 6312(51) 653..010(5..48)) 4529..45((31.16.)0) 1522--2229 6673..58((65..79)) 6674..01((66..04)) 6626..63((665..07)) 29-36 61.107.9) 60.9(7.7) 60.5(8.4) 1-36 300.3(22.5) 300.1(24.1) 291.3(25.5) ba SDatyanodfarWdeadneivnigati=onTesits rDaeypor1.ted in parentheses. JThoenrcekhweeerree-Tneorpssttartaisttiesctall(yp <si0g.n0i5f)i.cant trends by --- w= Company Sanitized.Doesnot contTSaCAiCnBI 9H-02-4D7a6y8:GSauvbagcehrSotnuidcyTionxRiactistywith One-Generaton Reproduction Evaluations DuPon-5990 TABLE60 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF F, FEMALE RATS Grove (mgD/OkSgE/.day) N DAYS on esta 5i 15 22 3296 1-1 o v1 25 vi-1 100 n un s MEAN BODY WEIGHT (grams) 160110.90073..70)5 117464..040076..77)) 129291..71((2201..86)) 5s7a.l0s((91.i0.)2) 139.7(14.0) 210726..81((1132..79)) 220.8(14.9) 6908..95((48..66)) 1a1.4(9.3) 210746..58((1162..83)) 227.3(21.4) Grove DOSE. 111 w-1 25 vi-1 100 --_ (mg/kgN/day) n u 5 DAYS oN rest MEAN BODY WEIGHT GAIN (grams) 1-8 8-15 1a206.(957..7)05 38.0(9.8) 1.807.0) 38.0(5.0) 42.5(6.3) 15-22 22-20 2335.07500..67)) 263.6.83((66..70)) 3257..37((56..69)) 20-36 21.4051) 18.0(5.4) 22.8(7.3) 1-36 160.1017.6) 163.9(17.7) 166.4(20.3) ba SDatyandofarWdeadneivniagti=onTesits rDaeypor1.ted in parentheses. TherJeonwcekrheeerneo-Tsetraptsitsrtaicatlelsty s(ipgn<if0i.0c5a)nt trends by -_-- Ta `CompanySanitized. Does notconTtSaCAiCanl H9L02-4D7a6y8:GavSaugbeshSrtouidcy TinoxRiactistywith One-Generation Reproduction Evahations Dupont-5990 TABLE 61 MEAN DAILY FOOD CONSUMPTION AND MEAN FOOD EFFICIENCY OF Fy MALERATS Gproosvee. (ma/g/day) Daesstaon 1o 2ee5e v1010 1 n 10 MEAN DAILY FOOD CONSUMPTION (grams) 16-185 1527:2229 29.36 0121.7008.10. 113 30(0.a6)d 2266.090(2..25)) 22.60.10(.2.03)) S256) 30.8.0) 1119.290(1..24)) 22583.100..10) 31.2600) 1-36 23.9(2.00 23.10.84 23.1(2.3) Gproosvee (ng/kg day) DnAeYSstaon 1 2s1 v1010 17 11 10 (grans weiMgEhAtN gFaOiOnD/gErFaFnIsCIfEoNoCdY consumed) a1-i8s 0D..540S11((.002365))b. 00..456114((..003363))d 00..454130((..005321)) 1222.229 000.32160000235)) 00..332864(..002268)) 00..331756((..002301)) 29536 0.200026) 0.283.023) 0.279(.03%) 136 o.3600019)c 0.371(.019)d 0.361.019) b3 DSatyandofarWdeadneivniagti=onTesits DraeyporI.ted in parentheses. oaNneae TJhoenrcekhweeerree-Tneorpssttartaisttiesctall(yb s<ig0n.i0f5i)cant trends by -_-- `Company Sanitized. Does notcontain TSCA CBI 1H9.02-4D7a6y8:GSauvbacgherSotnuidcy TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont:5990 TABL6E2 MEAN DAILY FOOD CONSUMPTION AND MEAN FOOD EFFICIENCY OF Fy FEMALERATS DGOroSuEp (mg/kNg/day) DApYSyon 81--185 1252--2229 20-36 1-36 mo1 2w5-1 v1i00i 1" 1n 5 MEAN DAILY FOOD CONSUMPTION (grams) 1172.4.002.0)BE 191.95.(4201.70)) 20.402.6) 1j6o.8a(@1..9o)d 1199..92(021.93)) 2012.7) 1161..710011.32)) 1199..82(021.54)) 20.5(2.6) meame 1msa.ed 17.50.68 GDroosev.e (mg/kgN/day) DTAeYsStaon m01 2v5-1 v1i00i 1 1 s (grams weiMgEhAtN gFaOiOnD/gErFaFmIsCIfEoNoCdY consuned) 15--815 00.345801((..003550))5: 00..348911((1.004718))d 00..438693((..003400)) 1252--2229 00..127333(..003570)) 00..217911((..003380)) 00..129682((..003209)) 20-36 0.151.036) 0.127.033) 0.155(.041) 136 o.serom9c 0.268(.0100d 0.271(.012) ba DsatyandofarWdeadneivnigati=oTnesits rDaeypor1.ted in parentheses ac nw--i106l TJhoenrcekhweeerree-Tneorpssttartaisttiesctall(yp s<ig0.n0i5f)icant trends by ao CompanySanitized. Doesnotcontain TSCA CBI 9H0-.2D4a7y68G:avSaugbeehSrtoundiyciTnoRxaitcistwyith One-Generation Reproduction Evaluations DuPon-5990 TABLE 63 SUMMARY OF CLINICAL OBSERVATIONS IN Fy RATS Fu MALE RATS Number `oOfbsReartvsatwiiotnh Given DOSE (mg/kgG/dRaOyU)P 1-01 I2I5E v1e0l0 No i 10 A0lBoSpEeRcViAaTIONS 1 o 1 Total No. of Rats with Masses 0 o 0 F, FEMALE RATS Number `oOfbsReartvsatwiiotnh Given DOSE (ng/ka/GdRaOyU)P TI0-1 2I5V-1 V1010 Now u s ~~ AOlBoSpEeRcVAiTaIONS . 1 o Total No. of Rats with Masses o o o Ttheestr;e pwer<e0n.o05statistically significant trends by Cochran-Armitage -- Te -- Company Sanitized.DoesnotcontTSaCAiCBnI H9-02-4D7a6y8:GSauvbagcehrSotnuidcy TinoxRiactistwyith One-Generaion Reproduction Evaluations DuPont-5990 TABLE 64 SUMMARY OF DEVELOPMENTAL LANDMARKS IN Fi RATS PREPUTIAL SEPARATION - F, MALE RATS DOSE (ng/kg/Gdraoyv)e 1-01 m2e5r v10a0 No i 10 AGE (Days) 43.9 aes as3 an am ae VAGINAL OPENING - F; FEMALE RATS Dose (mg/kgG/dRaOyU)P 110-1 2v51 v1i0-01 No a7 pt 9 AGE (Days)a 31.4 31.6 31.6 2.3) @.0) 2.0 ~ Data summarized as: SNetaanndard Deviation a AigneApwapsendciaxlcXu:latTeedstasdafyoll+ow2s0 duasyisng=daAtgae p(rdeasyes)n.ted TTheerrpestwrearetesnto: sptat<is0t.i05cally significant trends by Jonckheere- ---- ww Company Sanitized. Doesnotcontain TSCAC81 ~ g g 22 288g ggg 2% 55 28 88 OR RE 2% 8% 2 2 no M6 S 9S no mo oo ga .E He &n AS S6 SS ne mo So sd } n 5g 3 3H8 I & 2 of = 5 5 5 8 85 8 3 ' 9 2% 85 9% 8% 8 3% 83 2 g 8 3. 8% g 5% PE 8% 28 BE 3 12 a82. 2 g ne an 46 6 S66 de mo os Fd 2 8a 5 8 F248 3H EH ~ 24 il 28 FP ---- ~ : 2 2 = 3= _ 85 i 5 3 53 %3 ism = 3= 8= 8= 3= 8= 23 2 023 3 uk 32 5 g So ga 8a #4 32 88 F& 8% 3 gfe 3 EE SE OEE EOE I. 3 ef i 3 E01g4 S L s Fgk s pr3 oF3LoEg3E: F 3LE E2 B00 fg,8 Boat opoa ~i i ~ 2g ca sd 2 2 2 2 2 ELE 3 #3 gi Sc gs gi gi RY : i8838 5 z 8 5 5 bd 1 Bs | 2: ii fi gf iE Bflemsd5aB fLrog BsGoln i 35 52 23 2 48 48 EEF iF ~ if3 3EE5s ggii:: Comeyentces. Bove rttn8GAGB - zH g 2 5s 5s 5353 :! pEHEEE 3= - = a5 & g 283F - gfEo fp TTT = 4 gg s&s & & & ' 5 g . gf BE EEE ER 3 EERE RE 5 Fd 1 8: 3 ] El 5 Jeg 2 81s 2 E8 FE5& i i ~i ER ~ 3 gs 2 s833 gp BEER SH ~ fIeg i. o88meE3 IE 32 s gag:2 8 oo85 8 ' z Cg 8H a. F SHORI E N EI E 1 2; 1 EB oil... &S zgg Sg oC8 E 38 :i 35 & 3 82 J3 df i ii gi8 EEE OE Comey entens. Sonam SEG ~ z g 2 5s sg :3 BR ogi Ss ge gi. 2 , G85 Esi o5d 4 gE FIER it 5 5 if ` i : g fi. w= E0 Ea ipass i zg 182 I- Pid g EEid 5 gi1:132 Jf BE el gcd iz 28 58 EE ER |3 Ze CompanySnes.Soe etTSCnACa =~ 3 : Ege - 3 < =Eg : : ~ gs2 3 FE i s2 3 7g5 4ig8 & 8 3 & 2i3: i ig8z ~ 3% HE oo oe : 3 i| Hagi Epi eo _i = 2 3 EgEE : 3 Bgegll gz BaF 8 | : i @ i & Li o Ad gE aieEE ,B T ESR BE gl. : ' CompanySarit. Dostcontan SCACal ~ oi Po Tl1g2f25.Ld gE 8a ; :iE i7 iLE8 gs i ~i i i img gt EH i L . 2:i . |B 538 HEP FP Er ~1 i g 2 LdPoD2 |: 52 TBoEuSlT - 4~~ ~oo an 53h E Zi Bi i ie 23 2 3si oz ozo: LEE SE i HY ; 1g gl fit ii ggo aki =yHi z i oe 32s% ~ 333 CBiHETx FE af BpeRlLs @ BEL ai E2 8% 3g2 E3:3 : CompanySantis, Bots soma 50mGo -! i i e ooBsbsi oooTc" i3E3 : 8H EE E i : 8 RR 1 0 oo Pgo L dE Z Hos oo so 2 i fiLids pig oofla" $8 5 IE 356 | & ul Bi PoE it 1 8 i i 1a oa z3 iH 2Eg1le8e 2E cs3 ii F BOE, gagE. 83 ~ 43 HHEEEL FTE OEEHHTE -8 i 4 z ii ' fi Hei Fi i i gd: By 5 EES 0 ool3ti. @5 Gest ooc oLlf8 puA:Y iPL. B3 E33 g cof0 |[rEg EE 1| " P- i 2 = 2< 2 0 5 5 2 3, go as ` I i3 ggo 1%g gg 23 & i: 5 Ggeidt eiyg i i i Pog 2s gion82 _& ELE LIF 23 ii 8 ENk]t] FBHis i 8 ( EHELI cfs os Sgose og@ MI BRIE % CompanySens Smarter GAGS ~ i i z i g: Bial. 5 oad Hemi 2 i Z8 i HE z Jozi off i Ll I 35 50 z : g fi dg7i ||f & a Bi g i 5 z BHiEEioeIs i g Poe $ 8 i8 51 = ig ig g; z3| --~ 3 EH | iEH gil:g ai E [a CompanySizes. Doe otomTa56AnO01 i| i 3 i 2 i Ba... 8 f83f . of 2 i " i gooGh oi 3 Hani oo 2 i Lg%z Rteosniii oo offg2 - Pl: J 2&8 10 " Fi IF.g fal i& ig Ee : 5 Ba : Iz i 5 Bn E=E; 3 So i & + 3 i ER i i IE ~ 545 33 ii PH g#gii8ggss 3H E8lE.% . Company Sanitize. Doss not contain TSCA Coll - z3: iii 2 | H< Roised i oe oe oo a oo 5 g ii z faql 0 0 o z LEFE i Feioeoo ooo dti: } - ET : : : 3 3 $& 53 i2% i it ~ 58 % BA: & gi8i 8 i * i zi g g8 Hi ig 08 2i: iiEEB gEEEgd i Bsi EEggRghEsE [2 8.02 Beg bg CompanySaris. GoortconT5a0AGn1 ~~ | Ca fois L:o i dm dlls |ir ff 1 18% J ad ~ 38 terior aa JERE E 4 i kt 3 o i Neale x il EERIE 10 EE hf ge g 2 E eli Fgpf BE [ol|ge-8g:. g 2g Bli EB HILpLEpLd ii} aByolog boopy dnriEeR if aT gE oe a Corey ti. vrnc TU z Po itlPoon] bk aHy B<. | 88 i hEeA Eo2 ooo BEE, fghtd TboaEiEaE 0ia "ait ; g 3 gBBE2 al ar I ul |eiih i leg PiFf i ELdhHea Fog lin | HEE i5 _ 2 fi d8 md 885 BELL 0H--2D4a76y8:GavSaubgeehSrtoundiyc TinoxRiactistwyithOneGeneration Reproduction Evaluations DuPont5990 FIGURES - Tan -- `Company Sanitized. Does not contain TSCA CBI 9H-02-4D7a6y8G:aSvuabgcehSrtoundcy iTnriRcaitstywithOne Generation Reproducion Evaluations - FIGURES Dupont59%0 EXPLANATORY NOTES Critical Dates Day 70 Lwaesrtedraeypodratteadfwriotmh tthhee msuablceharnondifcetmoaxliecirtaytandiemsailgsn.atBedodfyorwreeipgrhotdsucctoilolnecetveadlduuartiinogn,s the cohabitation and post-mating periods ae reported in the Reproductive Toxicology section. Day 90 Last dayoftest substance administration for male and female rats designated for one-month and 3-month recovery periods. Day91 Last dayofbody weight data collection formaleand female ras designated for the 91-day exposure period. Day 94 9La1s-tdadyayeoxfpotseustrespuebrsitoadn.ce administration or male rats designated or the Day95 + Male rats designatedforthe 91-day exposure period were sacrificed. Last dayof test substance administration for female ras designated for the 91- day exposure period. Day 96 Female rats designated for 91-day exposure period were sacrificed. - Day 119. rLaesctovdearyyopferbiooddy weight data collection for rats designated for the one-month Day 123 Male rats designated for the one-month recovery were sacrificed. Day 124. Female rat designated or the one-month recovery were sacrificed Day 182 Last dayofnonasted body weight data collectionfo rats designated for the 3- month recovery period. Day 183 Male and female ats designated forthe 3-month recovery period were sacrificed. -- = `Company Sanitized. Does not contain TSCA CBI ~8 3 i 3 z : ii 8] iiS 3 :| ~ 38 iH> 2 z258 32 agg tod LR 8 X ge 1hy 18 BY I 14% 5 _ eS BeBE gBriafz B 3 C : Sd a 2 Ie hWe h Fon NN = CEE Say SRSN 2 z :< :8 f a k 3 ca5 2 "s aS 3% RT g 8&8 8 8 8g 8 (8) wiBtop Apogl uso `CompanySanitized. Does not contain TSCA CBI - 2 2 - 2 i 5g 12z ! 3 #ig4 ~ 4 =| =2 53)8 3533 2253 tadk ePonp|AW30 gq i Rel := i5 an =5 ge --1INk ns WL EE 253 Ryd =: iy 8g ls NNbY gi ph s i= % AY S .2. 3 e [hg-1 -8 Ek 2 &| 2d oa [ Ile2 [ :5 = B = g 2g (8) Bom Apog ura -g N a2e Samper Santos, Boos WAH TINTS ~ i --a 2 5s3e5:9 2bd1 EGoiagm -d0e | ------ . Zi| ||g2 gz: | ------------7 E - gg2 ' =2E3F [3 d os i 3 E3 =? 45z a23 1J: 82Z% g g dg 32 5 2 iH < 2 i ee EEE EEEE ( whuans dup quisiog ~ 594 =| Company Sanitzad, Doesnot containTSCA GI ~ 2 ~ 8 ]| 2 18 g i232 13 i 22 824 ~ 35 =8 $35333 $o2P8t HoEsEo 2 23 3i= i =k ] *zB5 [| =z Poyd g? gE = 2 3 Zz a < 22 1 2 . 2 -- s % 2 PO E 8 8 2 8 8 8 (3 whuans duo quuaiog Company Sanitzed. Doss no contain TSCA CBI ~ Z| - i| 3 3 .8$ iid i22] ~ 5234 =| g | z5 | g 3 oZe 25 2E8Z | 2g 2 = = 5N3YEI5R: [352 'H 2Zsg| 2 coaul . i ud3 33 23i 1< 3 2 e E 8E 8E e 5E 83 Re 3 E3 E38 E (3wauons duo quiyputy CompanySarin, Som TIOAGS! $2 ] - i 5 5 g! gl3 i 2& of ii 323 3H 9 -- 54 =8 " 2 : zz Z 2 E og EE = g| =] 2zg z588 .3 228 EEXE 3: RE |CEoqssssg 2.2 --- ]7 |g & 3, ng g i=t] | : 5 i || Fe -------- 885% 2% 3% 338338 (3%) wluang dup quipuy CompanySaniized. Doss notcontain TSCA CBI ~ 2 g 53E8E g 2Ees : fags 2SCC coe HE `a. =g | 5 || 8g To 2 CB | 3 Bg= 2 z Z g g i |, zi pt 32 z i2 $i 432 zdE < id : 15%55 =g ~ 525 =8 j i5 T s sz= e (08) swawsnop Jo open SompSeH ny Gov ta -_ 8 32 : 533da 23 2Lo3 t Ea2 8 -- ooo ggE || -- :88 g so -- 32 J EZ i 2=:5 32 Z3 5 |-- | ||| z 5 g | 5 2 | &g aFE | 8 Ee LT SE 8 25 g= (099) swsnojpo wong --~ 54 8 1] 1: 2 I $i3:: IF =i2 L #3 Company Sanitized. Doss not contain TSOA GBI -i 3 | 2 Z :58 5 d8 $ 2: iH z2y ~ 38 =| 4z 3 2 2: |-- g :Qe | 2& ggrE 2533 2P3EE Ea E8 O@D@m ig 1 o: Bg E2 Ez : :a g g SE gf g TERE iE SS 0 NS N i:Ts i SISWRI i 1i 3 z 5i -- 38 --3s8 oEes c Company Sats. Bosrotconsi TsCAGa --g <3 1 - 8 3 : 2 1 2 E<lg & 22:2% 53] 328 58 --~ 38 2 SE 3 25 8 i gF322 82P3E3 Ea2 &ec =a ooa ew s 000 2g | | -- . g2 | 8; & |-- g| 2 | fz i zg 22|| 38 | 5o3sIosi g: 8 = =| t S|| 2| : @4 i E=: || i gE g< 85+s 8= 88888 8sFa 1 gg (oppo. = Company Saitize. Does not contain TSCA Call 0H--2D4a76y8:GaSvuabgcehrSotnuidcyTwoixtihcOitnyeGeneration Reproduction Evaluations DuPon-5990 APPENDICES -- mm Company Sanitized. Doss not contain TSCA CBI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcyTwoixtihcOintye-Generation Reproduction Evaluations DuPont5990 APPENDIX A ANALYTICAL DATA `Company Sanitized. Doesnot conTtSaCAiCBnI 910.2-4D7a6y8:GaSvuabgcehrSotnuidcyTwoixtihciOtnye-Generation Reproduction Evaluations DuPont-5990 `Table I. Concentration Verification and Stability ofH-24768 in Dosing Solutions Preparation Day mg/ml. H24768 Percent Sample Type Nominal Measured Nominal Co"nTcesetntDraayti0on Verification(A) Control 00 NDB) - 3331 3 924 33M3e2an(); 282 2972021 84.7 @.2 cr7% 13331 21 08 13.3320) 1.6 87.0 Mean: 1194035 9.9 cr.3% 6667-10) 604 906 66.6720) 551 826 Mean); 57.837 #6.) _ cr.e% Stability 5-Hour Room Temperature 3330) 293 880 5-HourRoom Temperature 13330) 16 870 5-HourRoom Temperature 6667) 581 87.1 4-Day Refrigerated. 333(CE) 314 943 4-Day Refrigerated 1333CE) 120 900 4-Day Refrigerated. 66.67CE) 589 883 TR) Dumpixltiucrae.te samplesperTove were analyzed. Mean, SD. and CV. caleulaed t verify uniformity of ((B)) MDeenaontersesnulot doefttehceteadl.l analyses orth duplicate samples. ((ED)) DMoesainngressoulluttoifotnhsesaomripgliendalaafntarlybseiisnagnhdeltdhefoorri4gdnaalyssaremfprliegerreaatenda.lyzSeadm.ples analyzeda sablity samples but no baseline samples were taken on he original preparation day (est day 39. -- = Company Sanitized. Does not contain TSCA C8 9H0.2-4D7a6y8:GaSvuagbesoSntuidcyTwriitchiOtnye.Generation Reprodsction Evahatons Dupont5950 "Table I. Concentration Verification and Stabilityof H-24768 in Dosing Solutions (Continued) Sample TypPropeentonDate ___N_ominamlgnLA2#Me6ss_ured NPoemwineaml TMar2000 VCeornicfeinctatriaotni(on) Control 00 ND) -- 50-1 an 944 502 Mean: 446532401 cv.3% 2960.)8 110000-21 897356 95765 `Mean: 9.05+0.4 (90.5) CV. 5% w2000012 30829 1907.035 Mean: 3c9.v6+a0.%9 (98.9) - 7001 2 902 7002Mean: 662415711 88.1 wh) cv.2% Stability ) Da5HyouRerfrRiogeormated 5500 553 06 11001724 Temperature() 4-DsaHyoRuerfrRiogeormated 110000 9o7m0 997702 Temperature() 4-D5aHyouRerfrRiogeormated "40000 aa13 11003532 Temperatre() DasHyouRerfRriogoermated 770000 872 192603 Temperature() A) EDxiccelptolveeryounmifoWrRmTitSySo9f3s,rSCe.0 wes led Tae eluded for een ie, SBC. (@ Denotes nordete ~ (C) Samplesheldfor4 daysrefrigerated,then hoursatroom temperature. _-- CompanySaniized. DossnotconTtSaCAiG8n1 1902.4D7a6y8GaSvuabgsehSrotniyewTiotxhiOcknye.GeerationReproduction xausions Dupont 5990 Pre"pTaarbaletiIo.nDCoanycentration Verification Joe mm H-24765 in Dosing Solutions Percent Sample Type Nominal Mesied Nominal `Test Day 32 Concentration VeriCfoinctartoioln(A) 00 ND) -- 3333321 320088 952156 Mean: c3v07i5%002 022) 11333312 11ss 886730 Mean: 11.6201 0 CV.1% s66666772-1 569107 598255 `Mean: 6c0v..4%31%9 (90.6) --~ Test Day42 Concentration VeriCfoinctartoioln(A) 00 ND) -- 3331 313 940 3332 312 93.7 Mean: c3r1.2o0%12 (93.7) 13331 12s 98 13.332 125 93.8 Mean: c1v2.5o%%00 93.8) 6667-1 588 882 66.672 51.6 87.3 `Mean: 5c8..210%.9 387.3) e R DeteE rs r emee e r: GompanySanitized. DoesntcontTSaCAiCanll 5151:20768G;aSvguebaSouitc TwiotihtOyn Generation Repti Evaluations Dupont599 P`TeaSbaplmeptIlLeo(cToonpteinued) Concentrat To i on mVergifnicaltiRonoOfrH-2m47-- 68 in Dosing SNPooleumwtiaeo!mns Test Day 91 VCeornicefnctariaotnion) Control 0.0 ND(B) -- 331 317 952 3332 3.18 95.5 `Mean: vow 317+0.01 95.2) 13331 124 20 13332 126 945 Mean: a12v5i%n01 (93.8) ssn 587 550 66.672 - B SooTnoma re Ce rim e Mean: 60.0 59.3409 90.0 (88.9) ---------------------- esters. Company Sanitzed. Goes nt conain TSCA Gal H9-02-4D7a6y8:GaSvuabcgherSotnuidcyTwoixtihciOtnye-Generaion Reproduction Evaluations Figure 1 Representative Analytical Calibration Curve 7 vEq=uat1i1o0n2f0o7r 4the+ f6i.ti9e6d93lin+e X so] ReSquared = 0.9991 I fa i" DuPont-5990 Concentration, maim Figure 1a: Calibration curve (R.T. = 7.9 minutes) showing linear fit (line) to replicatepeak height measurements (squares) for calibration solutionsof H-24768 diluted over a concentration range of 1.0216 - 105.108 mg/mL. 20] YE'qsuat1i0o5n2f0o8r02the+ f4i.e16d50tin*e:X R-Squared = 0.9992 z i. i Concentration, mg/m Figure 1b: Calibration curve (RT. = 8.2 minutes) showing linear fit (line) to replicate peak height measurements (squares) for calibration solutionsof H-24768 diluted over a concentration range of 1.0216 105.108 mg/mL. Fra `Company Sanitized. Does not contain TSCA C8 9H-02.4D7a6y8:GaSvuabgcehSrtoundcyTwoixtihciOtnye-Generaton Reproduction Evaluations Figure 1 (continued) `RepreAnaslyteicanlCtaliabrattioinCvureve wo] Evquaatiosn faor the+ f2it9te9d 3li0ne x R-Squared = 0.9993 2i DuPont5590 Concentuation, mp/mL Figure le: Calibration curve (R.T. = 8.5 minutes) showing linear fit (line) to replicate peak height measurements (squares) for calibration --- solutionsof H-24768 diluted over a concentration range of 1.0216 105.108 mg/mL. 0] YEq=uat0i8o6n6f6o3r 3the+ f4it2t9ed01linc+. x Resquared = 0.9993 5 ife Concentration, mg/mL Figure 1d: Calibration curve (R.T. = 8.9-9.0 minutes) showing linear fit (line) to replicate peak height measurements (squares) for calibration solutionsofH-24768 diluted over a concentration range of 1.0216 10 5.108 mg/mL. -_-- Company Sanitized. Does not contain TSCA CBI 9H-02.4D7a6y8:GaSvuabgcehrSounidcyTwoixtihciOtnye-Generaion Reproduction Evahations - Figure 2 ReprGe ass Chre oman togt rapa hyChtroi matv ogre ams [po Dupont 5990 || ow Figure 2a: Representative GC chromatogram of0mg/mL (control) sample. Retention times used for H-24768areapproximately 7.9, 8.2, 8.5, and 9.0 minutes. I I. 1 |= ss |= 11 Lee Figure 2b: Representative GC chromatogramof66,67 mg/mL H-24768 dosing solution diluted to a nominal concentration of 3.33 mg/mL. The measured concentration ofthe representative solution is 60.4 mg/mL. | ts |Figure 2c: RepresentatGiCvechrom|atogramof3.315 mg/mL H-24768 analytical reference solution. Ee `Company Sanitzed. Does not contain TSCA CBI 0H--2D4a76y8:GaSvuabgcehrSotnuidcyTwoixtihcOintey-Generation Reproduction Evaluations DuPont-5990 APPENDIX B INDIVIDUAL DOSE VOLUMES -- = CompanySanitized. Dosnot containTSCA CBI 9H.02-4D7a6y8:GaSvuabgcehSrtoundcyTwoiitchiOtnye-Generation Reproduction Evaluations - INDIVIDUAL DOSE VOLUMES EXPLANATORY NOTES Dupont 5950 CriticalDates Day 70 Day90 Day 94 Day 95 Day 96 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Dose volumes administered during the cohabitation and post-mating periods are documented in study records. Last dayoftest substance administration for male and female rats designated for `one-month and 3-month recovery periods. Last dayoftest substance administration for male rats designated for the 91-day exposure period. Last dayoftest substance administration for female rats designated for the 91-day exposure period. Female rats designatedfor91-day exposure period were sacrificed. Footnotes - a. Group I, male rat #646367 was inadvertently not fasted on day 94, prior to bleeding and scheduled sacrifice on day 95. This lackoffasting was discovered on day 95. The rat was dosed on day 95, fasted, then bled for clinical pathology and sacrificed on test day 96. The. data for this at from test day 96 was included with the data for the other rats collected at the time of their sacrifice, on test day 95. The additional dayofdosing is not expected to affect results, especially since the rat was a control rat. The extra dosing volume from test day 95 will be reported in the appendix but not included in the table ofmean dose volumes, since it b. wOanstteshtedoanyl2y1m,alGeroruatpdIoIs,eRdaotn6t4h6a4t5d8ayw.as inadvertently dosed twice. . Animal may not have received total dose. Due to error, dose volumewas not recorded. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extremis -- = Company Sanitized. Doesnotcontain TSCA CBI a z F. IIIIIaIIIIIINAIIIIAITIANIANT g: 8 ommmommmmnommmmmnn | J 27 BL mmm i3 Ia gil. mmmmIIIIIIRAIIINIIIIIAND &f i 1 . i ITT TA IAA 1! i --- 3=5| i SEB 28 TE ON Res ONN ANG SRR SRE RAS8S DRESSY ERR 3pi3p3ib 3bi3b 3bi3thbbb rtpbIbIbTbIbIbTTbIbTbIbTbbeRbIbTbTbbEbR04 Gomoany Sarees. Doms contaTSOAGSY ~3 g 3 8 aaa ans EI) 8i AAA naa ~- | 2 2 8 TT RENNER 8, nynesmurmeveananaceatavensesnsanasinnganneess [5 2i i E. i gs Aaa g 2 ass ii I 28 FRI SIR RII RR SII RII HRI IINKI ININD 2 a 3 AERA RnR 2g >B Company Sits,BossmtcToEmRiGEnH -f 3 RRR mm CRI ERER gz . smmmmmemESSRIEEen 21 33|: BOE.3> AIIIINIAINIAIININIIIINIINIaLD s SRRmnEms RLInaLs 11 . A 5 P IRITIIIIIIIIINIIINIIRIAINAN ii gk RITALIN EF i, it = IIIA AR 3H HY ~~ i BEEsBisciassrissmisstusinsisinasiaiaiaem Company Satz.Doesno corTtSCiA Gt ~3 E 2 RR RITIIIS i 22 gz Bo - |g Br gi 1 : I I A Ia ANAS TRAIAN 3 IAA AIR ! An amIaann i 2% Wo3 ta - 2g A A A A AA Anas i 2 i JS ISINSA BE IHRE EE ; GIItesrsaatERseausesEsaenRanmerneeanres 333EEIEIccssEEIIiicocssssssisiissssEisiiiss CompanySanitized. Doesnot conTtSaCAiCBnI 3 a ANIIIIIASATIIIIIIINIIAALIAIRTISIATLINCINIIaNnI : 8 I ARlinncinghI anmnneIeIeIenInI neIsnIn AIA NARI i oreo :; Ww on E2o AI RSIRAICAINI ARAGAGGAIAN5I3I I5ANNAANTIII A IT gi SL rn i : Bp mr aneminaeaIaTIIsIssITIng I 2b mI | ~ i 5 IAITINIIIIANIIINIANAIICITGRNINIAITIRIALIAINGD 58 s IIIIIAIIIIINIIRIIAIIIIINIINGINITINITINTIRINN i EF, i + FIT AA H ' : 333335ssannsasaasanannenesysasnsagransany [TT ---- ~8 pos EE aes PRE SRE i ~ J ii 1 5 & 28 &f i i 9) i 3i RI ee m RARERI m RR I m ex gi : vw BIIAR333 RNI EASA N 8z % 2 25:3 AIIINIE AAEASARNINNASNNNNAAMAANIAAARIAAA RI xc aR ER ERI I RAR IR sRMnEOTIINNNIN SI8N9eIrIENIIINISIINGaNRINNIIRIINNINNIIIRILNCIRNIEINEI & CRI 5% 3 eX 3J HIRI RI TRIO HO He HIN 8i a A aaSEas 3! H rggpsersiagasesynrnaasRnoassar nessa ens Company Sanitzed, Does not contain TSCA CBI ~ H 3 2 233333337 335% i Ra 2a 8z 3. - |g 8= | 37 3il 2 5. : 1d 2 & i z8| 2 FIRB EG 3333333 aE 333333332 symm ARISTRIN SEA 2332950 3 221330%5% 2130 TAT TRIRERI 5 wun fF DIB 22eAaneANId BRR ComprySri. omsoteon 36 Cl - 5 . z 87 3? 3 3 CIR ichic i = unas mm --- [i 8, asasanes ames 1 3337333 . mgnmannan | i gz i 5 S3I3IINET IN zi 333TIIIII i + 233332 0 iz SRIRAIII iqz s 333330333 And 5 iy i 3 2 333333332 303 EE I 3333533933 RIAA 4 ; 33838857 gnagssasnancanaantesasansaspaTainay GompanySaiizad. Doesne containTSCACBI ~ 2 = ANINNRRANRARINANNNNGASAGNAGAN; i TA y PRR 1 2 ~ 33333333333IRI33RRARIIIAANANAAAAL gi ~ : {PI I 3 3p mee a 2 i 8 RIL i: oi ZRIIZIIIIIITIIEIIEELLEIGaaA 3 : $ nnn i EE nnn if 2 CompanySartesd,DoonocontTSa0AiCnl - 82g 2 r TIIIIIINY IITTIIIIRISRIREIITINITSE z GR T + INI IRIIITIIIIIIIIIIIIIIIIN g: So: mIIEIEIRIRIIRRTG - 5f 3 ? momma A HB2.i emsssmmmmeassssisss =| I] 3 SHR AANANVIRNAHNEANNTNDR AS NN SRR N 0 shel !3 8 5p TEIN 3 Es iit a Fans anennamnnaniisianna I - 8 OEEEEEEEREIEEEIRSISSFFIIFSIEIEEREE: Company Sanz. Dossnotonain T5CACa - z i a ARAAEIMAIAGAEARII AIN z : IRIIIIAAIIZAAIARAIAAIAIAIANII 8 bE ERD EA ER RIN RT RRR 2 ARAANARINAARIRANIAN AAAI 1 ~ : IRENE ANANAAAARAI IIA ji g : J EEO EENBE GRR SC i 1 g s 2 & a i28 i& lop i 2i if E. AAARIIRIIRIIIERIIIEIAGAASNAAIAAT SA3333ARAAAT NARITA S3IIAIAIALIIIRIIRIEANAGI SARA IANNIIIANNGENAAAAAAAT Company Sanilized. Does notcontain TSCA CBI ~8 i z PIII z sR EES 2 5 TITIES gi 3 5 III - gf s 8. sanuensieanstntassncenvencmennanae & |4 FaB. A mommmamYmT A aaSmAommmrs HE i + IIIA & & fy % 55 7 SITII IIT O i 5 Foomersneamosamanamanan CompanySantas. GostcarainTso co ~ % 2 s TINIINNIIIIIIIIANIIIIIIINNIIIS i 3 MSR g TESS Tp ITIL 8i g x SIIINIEIIMIIIIAINISIIIIIIIIIININ -z 8. eysmenssmesnacanasciseensisgneasaes 2i i Bo rmImISRNIIINININIR ia 81 2 a SIIIIIIIIIIIIAINISIIRIIIINININ & i gzd oad+, FIIRIIIAIIIIIIINIIIIIINININ 3 oT rinamenannazesanaseneaniassasennane 8 3ITIITIITTITTITTTITTITTIISTEIeEEE [ET ---- ~8 2 IIIT i z i Zo mIIIIIRTIAENIIIIIIIERICIINSED i ~ |:3 So = 3 333IITITAAAIAITTNIITAINE 4) 8. IIIIIIIIIIIIINIIIIITIIIIIINIANE : L8g| EBgE-: sonusIaavvamsanaodnInsnveIosnsIaIvINImIoOInnIaAn i i ISEINNRITMIIIIMMAIIIINAR 28 ep IERIIACNICIRIRIIIIRIIAAINIAIAIAND it Fa i I IIIT IIIa 3E 3 Cores Sri, oe ean 150A 8 ~8 [ 3 ee : i g=Eie Q2u3aTwsgInSyUTaItIaNnIaIe - 2i 4 ]li::ps 3 3 Smee ene Treen i mms 3 S ] & Hi 4 -i Bop IR RT TE SIRE i 3ESEIRIIERIISECERIIITEISESiNASN ComporySins. ovataTSA ~3 2 gsm gsm gg symm So 3 TemmemauTLmaTen 2 3 8 RII i gd 24 , TIINIIIINIIE % ES i 2 3 rT 1 gd 35sIsEssIaBasIsiaIasisIsIsEasiniass Company Sanz.Bosra conain TSACot -f 5 + RNIINEIIIIIINIIIISIIIINALINN 3 TL IIIA z I --- af $ 8. nnIIIIIIIIInIIInInIIIIINN : 21 BJIl BE.5:op se emsA mmmsmnmien 0 . ITIL . IIIINTIIIIIINIAIIISIIIIIIITIIN iI 24 Lo SII 13 . EF ommoemssessneaseerneese Company Saiz. DoortcontTSaCAiGn1 - i a IRRIISINNIINNIIIIIRRNNICIIIRINAANGS i : IRIIITIREIIWIIINMINEIIANSIE SRRIIIIMIIMWIIAIMIAINAIS RR 2. III gi 3 = SIINIRNANANINIERIRIRNNANAAA > 5 38 :3 IRECINANIMMINCIITIASINEIIAEG EL i 7x IRIIIIIRGIINECIRANIRANAANAGNAm 28 a IIRRAINALEIRIICNIIMIANAN it ii inn iH ~ 584 o IRIAN R5H a 33IzzIizsasIEiiizzeiziavizzavEsa: `CompanySanilized. DoesnotcontTSaCAiCnBI ~8 i E 3 s 8i RBA3N3GE3R3A5N3G5A3E33ESR3E5N35A3AA5A0N0A%%N3AC%a3e3N0r5a5w% EEg = SANRINAIAGIINGRANINGRRNINERERINERNY u 3 EI SARANGI es ARIRIERSIANRAIINNGNNIE :z 5od gis d RnR i = FN IIINIIIAIIAAINIINIANIIRNINNY ComerSati. BosraTSAO - 3: i 8 AI ANN A ARA ARA ITA z Fgc: SInIEIaGEIINIIIIIIIIZIniIIaSIaLiza 3: A RRL IA IAIN IRAN -~ 2 2El7 A ARARIAAINANIRANAANNLY : 1 F2 Ts TAIIINARIIRRZZIIRISIIIAAAAA a RIA i 5FE Pr Rooa ho 2 m 0 28 ~i S sauseprasuILIORTITREAARTARENRLES SEIRISEITETISECIEIsERIsiiiinizis Company Santos, Does notT50aA 81 ~8 5 2 5 III IIIRINANIIIIIINININANT i 3 Tn IIIINIID DEIIIIIIIIIATIIIIIIINE gi Soa IIIA RIIISSISIISIIIIINIIINI: - 8g. gmanenguss nosssesesesusiessenened %: 3 Braid Addi ddd dda a fi 8 IEIIINIIL INITIATE i gs 5 + Iamissvasnslooamsamsmessiaasaa i 2 5 IIAEIIIIINIASIIIIIIINAANIIINNG a i3al +ad| IIIIINIIIRANIITIIIIIIIALIINIANNNN i2f +pdFOIIIIIAIIIIIISTIINIIIAINANS 2 Teens ~i i sREEIgIIIIGESIIIRESIEINIGSRERONE [ET ---- -8 : mnmmn 3 : J323ITIRINT ARUIRIIIIIIRARGIANAAD : TA3IRINT BRNLmLEmNLLn FR 3 5 IIINITIINT IIITIIBIITIINIIII 8i g = IIGNNININE ZERIZIIAERIRIIIIRZRIIIZ --- 8i E ; 2337733333 33533IIRIRINIINIANIIN 3 8i nae Ny 2 S 13 9) --~E5H4 v | WITS NANRARLIRNTNN i F II323039530 IISIINININIIIANGINIIN REE RES ASAE NIRA ERLE EEREREEEERLEIEIEEERRIERERRTEREIERRRERERIERSEERIEIERANG `Company Sanitized. Doesnotcontain TSCA CBI ~8 : 3 THETNRSN 3 gsm 3 z JEo go: I Gu InIg agSay we Ee sammunaon ~ :f 3oS 28c i gz I 5 ]; mmm MmNER ER HIT Ny se, MINTRNR OT 1i4 + &FoaIsaIsIIEaN 3 2 : -3: : z : 1 g CompanySantee. Boentcon55tGio ~~ z 3 p wm g 2 5 smn: gi g 5 IEGIENEEE NN - zd 5 mamas an 2z 3 g8.8 i 21 g 5 3i SsAmtmaenovseosiieenaoe Ip IININT IEES A50R HIE x o I9imasEysen ne y TIT 28$ + | GEENIINEES I Fann i : g TornTIIIEE an 3 H 3 : 3 3. = 3 : - CompanySanizad. Doo ot contTSaAiGnl -8 : Ae Luna Rt man nsne : INIT SL ANAT A Rs : IBN pI To. SII IIIIIIIIIEAIIIIINIIIIIIIIII gZ g : RREIRNIIIININNIANAssNNInnAnAAn Annan A J 3 8 LomImmmmImIImLRnIaIaen| gl 8 A ST AR3IIIINIINIIIEIIIIIEIIZIIIIIAZAITANANaNEY ; i iz gi RNAI aes i3 Hy: ARIEIRNIIIINIANAANIAANNNANANANAANA 3 saszesssunsseasassasnasensansasasansarszisann Compiny Saritzed. Dossno contTaSiCnA CBI -f pA pA ARR : 2 : 2 To IIA gi Fr I ~ 2z I 8. ceemmmmmmrssenmTmIGERm io 1 PI AY i3 28 3 TI TIT it 1% 3 : NnNINNNnInAnILIINS it i. CompanySass. DoesrocontTSaCAiGnBI ~ 3 a 8 S2ASAIRRNSIIINNITIZRINEZ 33M3ER33 SEsNNEAAk i i z i i 22 3 :& 2ARIRIRIINNIRINREINALE sm 8 n 8 2 ARRAN AAR AARAARAANNANRNRY 1s - 5 i 8 8 SARSRANAINIIINANSANEISAE GIANG J 27 ` | B . cnmeenrcennvannuroncencaacunsssamanaancenees i ii 28 3 ARRIREIIINNRNGISANNANGANININANRGAIAANANGR EE ii 2 BE 7 3 3 AARnaNaInIRRRIANARINRINIANNANAIIARN 3 EP, 2g 3 Company Sates. sonrtconTtSOiACnEI ~~ i 2 : SININANTIIARIIIANIAY AANA Arana gZz i AA ARAAIAINATS ARAN Anaad 5 SRIRASRNIRIIZNSATLARLIRT 33505333 ALGAE li - z A 8 SIINTIIINNIAINEING;aNAS aamamade smmmmams I 3 g : EEE BERR Ra RRR I en S WER B SASRAR3ISRIR3NARIIRIATIZ G3R3GR3 LEANNA 3 2 5 =AdRdRIRRRRNRRARREAR3337 2RA3GA3T SIAALAANANL 3 3d Company Set. Soestoman HG GBH -3 Z| 3 + IMIIIIENIIIIVIOINN 33MIN ANIIINIIIN z 1 TURRET WN Ws Tp IIITIIIIIIIASITAINNNNNT B3EINII AEMnIIRON: gi EE5 d TIIIMITIMIINIIIND BAIT ANNI - | & o IiIIIITISITIINAENY ASHLEE ammsmmzam IT 3B :mmmIIIIIaaniIIICNGT aSanRIIoasIIIIaaEE Ig g IIIIITIAIINNIINNGNAD 3OMII aaEINnaIN: z @ SIITIIIITIININIIIANIT BINT SINE ]3 z op TIIIIMIIIIIIAIED ANI ANIA Ef i: i + TOTTI NI Mm af i: 4 SBEENIREIIEIIAAEIIAEIANGIAATUESARGIAIIALNN Compa SEB SOATRONS) - z a we WIIG 3 pixcdieheehh : SRTIITLRAIIVINATNIL FANGS 2A : FRRERRTNTRIT 30S nan ERIM fm mn 2 s ARAEREEINIANAAIGANAN 333433 aaa g3 (i8s 5g gg: :z ex IININIISEINEANNIINIANNGCG Mmm dAstsmm FAIRING ATGAIM AEA . IWATE A0333 Amana 1i e ZRARIIEIIARRIZAAZ0IIAAIL 2A AAA 2fs8 wiy} TRRITIIRIEIAZNAIND 3333057 Ae 3 v3 TIIIIIIIIIIIIIIIIINS TRTIIIN TENINIIINE ini 3 % eesnsngsnnzEsssssneIsasisEs s9IRIREEITIIAALT Company Sanitized. Does not contain TSCA CBI -8 : 2 s EEE z : SIIARNINNNANNEY : SgRIRnAInENANI a1 gz E noeaE amanR nanaE nTY 3 S23GRRRRNIEIAEE - 58 5 s 33a 3a ie f 8 e : 333adaiaaaaoann pei bee 33RIARIAAE fiche] EER] 3 ceme3 anea ane bbc 2 Wan or 33333 RIFE i Ii3 ~ 4 =8| : { aaa [za oifF anenenenionaen aszammnans 5 SEssnaEmeannvaassnacaaneueaanetnannaaantt BEEIIIIIIIIIITIIIITIIIIITILLILTTILTITI33IE: CompanySaniized. Does not contain TSCA CBI ~ 3 JEx gi aHnLonIawNeynmn g 5 InERIIINIIEESS ~ 8i J 27 45 5Bss seman 33nsamamas s 333005050 5 5 GEmRIIIIIIINN ix 2 2& 4 27%7mTEsStIoeae i sg ZURIAIIIIIIRAN 3a00naa30 qgeaneanca 33naasaEaY 28] T3ErEEII III rena IEE IIE IER ERATE CompanySantzad.Does not onSaOA nGBI ~ f: 3 z aan i 2 andant 8 fi - # 4 Zz. a Sz nnaany an BIA : 3 gs. A saa T Ia 12 i nA an TAN at Te i i5E53 i 23 --- 353 =8 ag TID LE mmIanaIIaIIIINEIALNITNIIAINANIALIING fe C3gEgEgSaomEaIgonuossosRssasatraangeRsEsEzLanenszzealLsEaRgsaaRna0naszutgRne i IIIT III IIIT II IIIT IS IIIILITITTITIITITLILNIIIL Company Sates. bos not araTsciA Gno ~ z 2 RAR anna : CIIIITIINIIIINIIIAINIANIIININ INANANININAD : ATR Sn aT FEmmnsmms -~ ] : 2 nnn sans 8i g Inno a ae 3! 3 8 sR nie IF 2% BL amasnsmisiasssesmiioni: esniesseees: 3 AAR RERN LRLR SE R SS 2?P 89099EETT I9TATE RNIN TRIE TIT 190910995 Y i : TI I Ta +L4H i2 2 ~ 33 8p SHRI nan oi;F rrerrimneIaSIIAEAIIIAIIIIATA ATaIINAANANT FF, oESIIIIIEiiciciiEiiiinsiiiisispiiiianiind Company Sanitized. Dossnotcontain TSCA Bi ~8 H 3 8 AERGAINARANRGIRIANGRRIARRGR ARAAN NAG i IBos 8 IoNIrIINIIe aNm IIo Iao aam SCdRE sEaaa B0a0ar EsEsR NEON0A CaaaC RInIEE AEIRE CISIa NAAAOIR LRITN :EE]Bana RaR AAAS , - i. A NAA ! CR I& tf i 2 Hon 8 Bp 3 B 13 3 ass ANIA TAIRA aaa naan nan 4a oan An aa AA An RS hh hh 0 hh oh dr Corgi sone eesti ne ~~ : IAAI IRAAIIIINAAAIIANINAANIANGNNA : SETIRAAIAIIIININIIINAAANIIIIAMGNGAR : IANA : 3E3I3RANAIIIINIRAAIIIIAAIAAIIIIIAININ Tr IRINA 8i : IIINNIEIRIIANAIININAANINIINANIIIINAGIIS - i! 3 g. mumssnenssssneesm 2 ] Eos matm ata ae ta il gz i dR 3A asa aRa a nssas 51 5ii SAA iE| a= &naEImIIIIIIIIRIIINNLIINANITIANANAANAER 3 H3283E33502805008885033ERE0T38R003508E5R `CompanySaniized.Doesnot contTSaCAiCnBI ~B i 2 a DIELS i Ts IIIA 8i SmI Ea s 5 smmmmImLSnnnsssnaas | 4B a emma ig CIEIIMINITIIIIIII IIIA ii iH a 28 2 8 88 8 8 0 08 8 3d 8 OS 13 4 F So aArnr ecnN nasAeeN snnN sonAeAsNR asNeN OneNnAiAeA nAaRnNN aAnAA sNnN aAsaR A nsNR nnaaN re i By [oS ------ ~~ 2 3 e TIITTRIIITEIIE TERT 3 fH sR $ PIII :3 } I mmm } g . rrr | 2: 1 5E:.: smomsosssesmesssssssmes 3 TOIT 3 z 3 TI A ii io1 go+ 5 TIT iini+ OI A I 3 4 RIEENRRE ERsR e aIN SSIRO nae Gorman Sant, Borst ~ GER ERE PRE TERE 3 oe ITMIIIIIIIIIIA 8i ERE Pa FE |g 333333333 | 2 3 8 mmm il 2 angmannaeana- g2 IRERAIISEIREG i 28 r 5 ARIANA i id i2 oCF E uonoR nasnE naanS aas Ine ars bERII IrTsaTAI SAIIWIWAW ak xmx i 5 J_WEmsmam ssn anessenn aNNIIEEANT azn cFamTenrIaann ~ 83 | sEssigsagaspississiosacacbisassaanate CompanySanitzed. DoesntcontainTSGA GBI ~4 i =E) 5 8i eGaAeSaEnSaHnGeAeSnEg 3 :8 5 mIIIEIANEANY i s A3333WIIII i: g28 is8 5 AIRMEN ia i 3 Foamsanamanaanas IRR aqIRIRA! 3335335338 33335353 ~ 38 I ospEsisispsiisisiotisismoisisiinizisisniiiiis Corp Sts.oes -8 2 E 2 AAA i i i z E3o. gi ITEmIDmImNInEeSSeInSNEEeNITAeNEnNnINTIaTIIneEETNaInIenNaNnnRanfnCeEYn Be oS 3 AR TRAIN ~~ 5 @ 2 aaanannsenenensnnseaennsan sans. 43 i 2 & 2 3 bi & i IAI ii i . AR ana 3 RE orotrtrsr h se otoh nsSaonnsataetshnel ratiauoabnonoSirkeas dtrs 2 es 3 1 sEsEsgEsEssissiasnIsEasibsinG CompanSatins,bos otcomain SOAGE -~ 8 2 i Fa amILIIIIILIIIIIIRNNT gi z S7I2I9IE aT RT Ta 32 dd -~ af 5 . nmnTIIIIIIIIIIIIIIIIIINND i i ZE3BZ, sruresesananesecsaenenqunesencagsas i2 2og > rm A A A ER 8 2 SIIIIIIIIILIIIIIIILIIIMIIIIISANNT i3 gd 2 3 IIIIIIIIRIIIMRIIIIIIIIMN i sb TTI Company Sanilzad. Does otcontain TSCA Gal ~ PN Eg o:z oIEanaasIIIEANIINIIIIIALIAIRANANNS 8 : ERRRR ERK ER EERERIKERREI) } 1 3 H IEgER. g 3z mI Re aonnaa anne RnR sINsNIIIMEIIIIIR Z i 3 ~ 8 23 anne 2 : IIIT IAI III IAT yy I asasasasaananannnanaitnas CompanSates. Goono containTSCACt - 2 EIEIIIIIIIIIIIIIIIIIIIIZEas i oR To mma Zi SL commmmImmmEIG ~ :i 4 1d 8B.: momma 3 1 s: mmumssmmnasc pd oy mmmmnaaIIIIIscIIiIncac i Pt ao Iss ne n 2% i; Company Sanitized. Does not conTtSaCAiCBnI ~ 3 3 i 3 32 gi CRR EO NAR AANAT ARTA AM AGEN MOONaSnONdY 5 5 IIINANIANIAINAISINAINTAIINN - 3! s Q , emeenaddnndecdasmsdmieenameandaaNes T 3 |I i gz 3 | 2d + IIIINAAANIINAIIIINAITIIAAIITIIINN EE i: 233 i: 3 2 A AddAdAAAA NANANN NAN NAN NAA N A aaAa ig I ESIEtEigissisissEsisissssEsisiaies CompanySaiizad. Doesnot conTtSaCAiGBnI ~ 2g aIIIIINEIIIINIER i ES AR gE zs :+ rh 00 C08 68 F808 CO TINIAN --_-- @ $ ImIINIIAINIIIII * 2i BB, semen i gz i SER 3 s IIIIMNIIINISIRANISIIAN 3g 2> o 2 i AINAIRAN 17 oD rms qo Company Said. Dos rt contain TSCA Gl - i3 3 8 AEEREEEGR z z z z 3E 2 8i I 1 ryRmy pA es osE xv er 33E3EEENEGRG >i i Ei i 5: |283 it FH 9 -- 35%8 PE3 IIIIIIWIREA F eeovanaennnaie 2 HEU SAR RENRE RAS S RTE sJEEEDiEsIiLsIsEsInLaIsRaIaCaCaRnAnRRaRLaEtRSaAt0SgE Company anaes tsi GAG ~~ f 2 5 dInIENEN i i z 2 5 mamma g7 32s: manasa --_ mf 2 8 , acanasanennasan A Ea drdddsssads I| F8Bo,.2 saeonm eennmenna anm 2 g2 {I 5 Sema 3 SaIIIEIIasIN & z gd 3 SRTIIIIIANIN | LE + TITEIRTISIINIT if : 5 IoesEasissasassataniantaniinatiiiye Company Sanlzad. Doe notcontain TSCAGRI -~ i 2 i Rn aaa i 3giTI = ER = 4 eB EL RAE ER AR RENEEEER EERE a nnn Ran an zi i eg. i gs a RAIA ag Tags 1 " 8 & ama a a gi 8 33333333 a 2 o 8 NEGIIIINGINANIINAIIIEIIIRERIIINEIED 54 3333833a5R0a0 sa3R0ER0R0nERE 23 [Rit i ConnyStd,Bosrotonan GAO 2 a AINIIIIIIIIIIINIIINIINNIIANINAINNY 2 7 i 3= Fa ImTOO gi 1.5. smn - 5 3f Smaa g 3 nFrr mIIe ITId ISIa LIEIIIIIITIIINNY : 2 i $2 : mmImmIIIIIEmIeIeIrIeeIeRnEn eEeIn EarNe 3 3 Tm @ IIIIIIIIITI IIAI iz 9 : i EIIIIANIIIIIANANAIAIINANIT INT 25] 3 i 3B TIIIIIIITI IIIT 3A if ig Gompany Saniized,Doesnce ontTaSCiACnBI -8 : RARERRRR RAR 2. g: 32 BEER EO ann - fi: aaa As RAIA i 3 | EAI ii 8 & 3333333333333333333333aImnaAaAE CompanSait, sot soma TSACo ~ i| 5 IERIE IANNIS i FIIs gi TmIIIaaIIIMIITIINSIININANINER * Zi | 2: moms il g + f 5 EIIIIIIANIIIMNIINIIISINIANANNNGR ii 3 2 IEIINIIIANNIIMNIINIIIIINIANINNNGD :i 2 5 3 IamImsINIIIIIANIRLIIINNRIISAINNN it ES H3 oax 3 ISIIINIINIIANIIIIIALIIIAAANIANANNN [RS ---- ~8 x 2 A Rae i : re A RRR 2 BERRIRRRNIARNAIIAARAAAAY i 3: AERIALS - | 88g.p sR nemsnnaiTeE saiseneiaeaE ninetiatay g? z I g 8 3333A3I3ITRI33AIAAAANAAAAAM 1 I i 1 Em 5k % 1 i 3 ~E3 5 3 BRIANn A n i: 8i. Ansa 3p3grrzzsassannceszsszscanssasaance Egssistegscsagesissanaganaanagig: GampanySanitized. DossnotconTtSaCAiCBnI ~~ 3: 2 IISIIRINENE z sR | 3 RRS J2 E IIEINSAIT IIAAIAAIN--I-- IN--I_A--I--I--S go: 2, symmmmssseessss |}; ~- 8! Es na :? 2 3HBIE BE,o: m R uA mmN er E s 5 4 mrimavasensseca-en-neenansenann I 3 nnerensnsdddssasdasdnndanndaass 8 + TTT % 32 a4) 22 8 8 8 8 OF Gomer, SomcomaTHEATE I| 5 2 8 III i 5 NNN NNNNN ANNAN y SR 2 oe ImIIEINEANRIEE gi -8 % 8 = mnIIIIIIEGREIED : i il aniiRaIRaNaIEs g Ea Co L 28 Y SEAN Company Sanzad. Does not conan TSCA GBI -5 2 s ERIE i 3 amma gamma Eg o= Summ g3 5 = s3mImaIIIINGE -- z2 : 5 IIR 8 g .& ig: 5 3i g3 asnencaveeassan aEanIIIIaNsa EATING & 2 zd + INIA 6i030 3 3 8 IIIA 3 &: Company Sariteed, Does not onan TSCA CBI ~fI ees i I FL IIIIIIIIIITIIIIIIIIIIIIINIIIIT gz ~ : ; III III ] IEgR. mmmssmnmmssssmmesssmnn | 38 a INIT i gz | LI IIIIIIIIIIIEIIIIIIIIT z . IIIT ii 224 -ik3 aa 3 LF mmeasaninnanaaaaaaan IEE [------ ~~ < a ener aes anansnaeenntn naessasenssassar 2 t hd dd dd dddd i i i 3E a 8i R ISIIRSaGIaAIAAT AGaLGsAGINGAAAT GIGsaGaInIaEm g. --- 82 IER g o igs an asa Somveneceeenceanacenveqesnsaaceviceasacencans 1 Ii zz| a2 3 i aAnTaAgNsInRvIanEvTaInNvIaIvIavIaNnIaInIeIneInIaNnInTaAvNeaIaIeNaInInNavAeNnAeInNaNy LE 2 5 IIIA IIIA 2a gasassazcanasssypasagegynasenusasasszanonsyn --~ i SEEISIISSEIEIISISICIISISISEIIISIIISESISRIESS [I ---- ~~ 33 2 Ba A AnaARTaaT2%n i 2: gi ana nauaTaasat ans 3 = Re nanan - | 5? BZ2i: 4 isamRsmmmRNIAZIRAmEALANINAEIIERIIINMIIGIRDY I" IE: i 2 Bana I 3z 1% 5 ~~ ig ERSRNNNRLEIRINANIINNINIANIZINIEIZANIEREIEIN: 5 it TnI i : Ar rh hehehheh rh ed oh 03 wd 8 dr wd oh 04 08 rh pemssssasrsnsRnsiREsRaeasnEansTaEEnnELsSsE I siisisisiisississnsisincEisisssssEnnaEE CompanySaiz. OostcoinTSCAG1 - 3 s NeImeNneIAeINnIAiganIeaAn ineneeaInen i i 1 RS 2 or IEIINIIIIINIISANANSNIIANAINTINIANIALIN gi Bor mA - 2i A |: EERE 3 + IIIIIIIIIIIIINNINIIIINIASIINANINIIANIN 1 IR z 5 omens mIIIIIRIIIIIIIATIIIARIASIANID 2% i i + rm EL ig 2 3 EERS3I3EAERAIERI2RE a0 NNEoSIA03TNSSER52283 8 [-------- ~ 3 EIR J RIANA Idr A RNG MR A GN TH GGSAANRAAGA GAR BG AG GAYrt gi 3 5 HINARI - af : g mmmmmmnmsmssssnes of 2 2d B g omnis pI TA z | : NIRA i4H ad3 IIA ol TE 58 iE 3 1 DEERE II CI rE SERIETy Company Sanitized. Does not contain TSCA CBI ~ ii BL mmm: 3 SE asm Tgi TIT III mI 1! --~ zB _ sorrrensesinsieiesnesmenessieeniessnans [0 zi HE. smn Jo 1 : | i it $3 Bg 3 3L momma TR qr GA eT A SA TRI AAA NANA ANNANA ANNAN ANNAN ANNAN AANA N ANNES Compo Sots. os etsoTSmCAaG1 ~ gm 2 zmzinaannonE g: mmm ~ |`gi!: TTI TERT Tom TE tom 2[3 i i REE NER EN 2d v mmm iy it SenaNRNAN Tm E28H Hi] =8 8 33333d333E33233233I33II3IITIITIITITTIIILIIR Campa Satz. DooroconTtSCiAGnB ~ 3 s III x : asaaRsen : ansa 3 AeNNaNNNaS 2 Imma gi : 5 NEIIIEIIIIIAN - z2 go susmaminanaaE 27 gs ig SNEIIEIIIIIELC ARIA 3 wns IF pide 3 i EE i 3 ~ 33 s SEIIIIAIIENEY i ansnaiIn ii 5 sms Sena ' : 35388385 Ens asganaasasNasRaaaGeRagassaasyy 1 3EEEEEEIIIEIIIIENINCIISNCEbIRCNNNNNRNINNESE H9-02-4D7a6y8G:aSvuabgcehrSotnuidcyTwoixtihciOtnye-Generation Reproduction Evaluations DuPon-5950 APPENDIX C INDIVIDUAL BODY WEIGHTS -= Company Sanitized. Does not contain TSCA CBI 01.-2D4a76y8;GaSvuabgcehrSotnuidcyTwoixtihciOtnye-Generation Reproduction Evaluations DuPont:5990 Critical Dates INDIVIDUAL BODY WEIGHTS EXPLANATORY NOTES Day 70 Last day data from the male and female rats designated for reproduction evaluations. were reported with the subchronic toxicity animals. Body weights collected during the cohabitation and post-mating periods are reported in the Reproductive: `Toxicology section. Day 91 Last dayof non-fasted body weight data collection for male and female rats designated for the 91-day exposure period. Day 95 Male rats designated for the 91-day exposure period were sacrificed. Day 96 Female rats designatedfor 91-day exposure period were sacrificed. Day 119. Last dayofnon-fasted body weight data collection for rats designated for the one`month recovery period. Day 123 Male rats designated for the one-month recwoervesaecrirficyed. Day 124 Female rats designated for the one-month recovery were sacrificed. Day 182 Last day of non-fasted body weight data collection for rats designated for the --- 3-month recovery period. Day 183 Male and female rats designated for the 3-month recovery period were sacrificed. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extremis - se `Company Sanitized. Does not contain TSCA CBI ~ 5 2 } ERIS & : S3RFOIRAERTRATIRIRISICRRICAITILATORGNING 2 B84 2 --_ a : OO EE BREN eT A MONS NR OMMND MERE $55 GRAMM & i J I AiiRRisiiisniintiiiaciansisarinasisdasiang SL GNglideRiiindeiissrissiisgsisesiidninssirass init cg%l 3 i $ RiNEAniRAttiii AR 3 i 333jesssEssasseasaneanenerassrunnnnaaansy [Tr ---- - 35 2 22. 200m 88 - zBZo. szmgensas eas i : Z 3 GesIne: aomn 2 $% dsgsfsces das agunvnanan mananceean [4 3aFIRATZANY FEELERS i F Ea R a & " Company Sanitized. Does not conTtSaCAiCnBI ~ 85 3 3 & 2 gs - 3: :3 {gl B HiIl og: g 43 g oi : if Ho2o ii 28 ; B28 m28a3n2 3 & 2838 aun ERE] 3 EEE =33 GompanySanized, Doss et conTSOaA Gnal ~f g3 g3 - 5: % :2 g= iz 8i zF&H IB mH ooaei i we 3 ~ 33 8538788550888 30ERA0nIRRRISRIRISISIREREINEE I3REEESRISTESIITEITECEEssIsTICEsEsBESINI CompanySaniized. Doesnotcontain TSCA CBI - i ; eeniieisissenitiuivseneianen 2 -- a noananmnoaneraeayaegannegnoaecny = | ol & & CII 28 3 L BRAEEIIRRBARIRASRSTAANLARSRIRLERER 3 0 Boonmesnnisan assassins ay i # RARRARGRNANRAAARANINRRARANANRARAAA 2 gx ; JERISEESIARAAAsSATRaygRIALAERSnTE Company Saized. ows not cota TSCA GBI ~ : FEE : Hi ? gg e a #3338 :2 02: smn g } mmm 3 3 fy3 23 2 B onorensneetzanteesscnanemnoennenann 4 So Z3fggdpddssddaddddddansdagaradndiny CompanySenki. Sore30ms a 2 2 Egg z; 2333a 2 3Ig5 g 3 2 1 4 3s3n3e8s3 "anne 7 3 a3 ie3s3a3s 143 i5e1 s2i3d3eds 9 Bl ZR 3IseEisiiiziIiIisEisizzivasEia: GompinySaiized. Doesne contTSaCAiCne -i 8 5 x ET 2 2 ; ome S$ GiiEdssistididisiseisnisscusivess 2 Eo mnmmIGnsSanmnusn 3 TrTTnTTEnTEanmenEREnmRRmmTRRIaTeen = 34 3 i2 z2 :3 SIRRAANrEARSCaRcEiRrIAASNRDARRRSRRIaRRRIRsUiARRSNRDSEiRrRIEsERNAALREZ : } ESssiiSinissntunistiiidgeneniis ;SHi oos: i [EPE E EEE Rb =8| # III TITIITITITIITITITIITITITIIIITIIT (CompanySanitized. Doesnot conTtSaCAiCBnI -8 z 2 3 35 g 2 FE] - 2a aersasescsesaesynsass evu o 23 & i a2 i33jigsises s 3 gop eResmmE Es - 4" ; 3 2 $ GEAIEGRiANE IEISindGididiis 28 RRTSOCRAn SITRInnISmmmasnanasases i F 20330333C00 dodsiasanastanssnsestes 8] IEIETEIISTIITIIITIIIIIIIILIIILIIIEE Company Saniized. Does no contain SCA GBI - Og : iB El a ea - 3 Bg 2 3 28d 3 i 3 one g# #8 5i i 2o - z=gz 3 @sgagme E3R = fHl Bo: 2 5gi8 5] 2 . nn - & o33 3 ? 3: " i & a 38 fl gL 2 iE i: 5 > 28 3 5% 3 iu 7 gE H sssssazscsssrasaree I333zzEszzeseisisyiaiizizzEizasy Company Sanitzed. Doss not contain TSCA CBI ! 2 cessssmieiineessdenuied disusvnc natfvisde I RSISILISLLACOSIRRSIVAINIT IRATILILY IATIIILNRIR 3 FUSAIARARARASAARATIRIEAS VRASRILS mAuARASAsin 2 z : iREEainaankininmngg aES 8 nnn gg one - 8EB , snsnsemismmennssseasnvsisaEcRsisscdaRnanRaisiessaacniaisasasiemcssaonsssicsnaasssenasszs ||g 2 rrnnnmennRan i 8 og eRRRRRRRRRRRR ] I EERE 5` 28 z 3 ARRRASNARANNRARASNARNANAIARANANRIIIITIRIQIIRARG i 343 o FoARaAmRRsAaRRmAnNAaRaIRnEnZAnCsRAsNsNNaUaNAnAnRAaInIAsNasNgAeanNrEAaeNnRnAaNnnEAynY zg PETITES IIIIIIII IIIT IIIT: CompanySartzed. Does no conanTSCA OBI - i2 2 : EHERY 2 gs g3 2 3& 3a oisE z 2 I IIATASIIILINIG 5 sagzneesingniss 5agidasds BEEGR EERPERERDN , ARSSIRSIIT 588838388 3 oF annnaeenscacenaanennounn onenanan vesmanvones HE 4 ; GARCIGLlINCRSNTATEGNEANS RRvasy AngmavesAs: EH EP 8 EIEEREIIEITINERARIES Company Sanizad. Doss notconan TSCA CE -~ 8 3 2338 z 3 E22 a8 isiosdnises Ei i3 EI : g i is 33 2H - 3 ig 8i 2 J. Ez: isgis & aqme 2 . 3201s ii si$4 pBaiars a B%ar eSgR3EsEsInEeEsSeaEnIissSissiEusssissnInoaEsasniaIsasTBEuoE sRiaussIuie IiIseiIansgbsiaGT CompanySanzad. Doss not containTSCACSI -8 sR dRiAd a inN i as deidi iand 2 Be armnriainiiinisasiiiiis g - Bo omenioinnanmmnnuna: 2 ; S8RIRREERRANAINIATARININERIARTRAIAARARIAARRR v 2& 3 51 CARNSEIRARNNRNANSARERRRRERRRARANANARRARARENAR g ii iLHI ITI Gompiny Saniizsd Dosnot contin TSCA Gal -f3 2 2 Ez iis 53 2888 - 5 sisaasafcsaaaasnzazfibsaanses 3? : isdgisiand R[RZAI55AR agvasgngesaznanemaeg [[29 i gEiddiigdsiddiy S3giisisag 1HE PREF ARRRARSIEAM RERRRSRANSRRRERSR RII LLMR SRARSRANsnIRniEeM] 28 i [EP ---- Cf z ; g38 ie: 53 Es iis gf or ~ EFS - gaan 4 83 iad io -2 & 3 2: Eas i$ 3 2| f or . 5 8388 ii 3 LI ia: EH La or | REELSIRE RRL ARI EAU ER ER SEen Toten CompanySaniize. Does ot conTtSaCAiGoni ~~ f 3 } SesfsesieiselSSstneaitidetanend 3 SIISRRRRASRANRAARNRRRRNSRNARRAREERAY 2 2 iz Z 2 - 8a } EnaErRaRcAnRnBaRnAsAoGncAaArGnEeRaEeRnGaAaInRsnEaRndsamadneosns "& 1c. z 2I Hiatal ARARANNNISNAANRANSIANRRANINTIIARIER z 5d 5 i28 _&EzH a 3, HETIL z SF RnR 4 Frremetihi en mni rSeRr AT tIhTmErReA 4I SiE3s3E3s3gcEEsIsEiEsssNiaissTiNgssEscaRsaEnaEgnnnsIsCiIsTnsEnnSeYg Company Saiized. Doesnco ontTaSAiCno a 5 2 i Asad 3 RARAR 2 ggsi pErEs) - AB. conessensancese 3 3& g2 3| go: Gisidgiddiasiis 23 ? Iit q T1 SEE EE E EE R RP EA R 2 : 383sonzasassasaananspagazazazoeacn Company Saitzsd. Dossnot contain TSCA Gai ~8 g 2 3 288% igEc) s oHiml g --- FE enna n Qo = 33588 a 2i 1 3B:: sFaaia 3 o w@mae g . Ps 25 i, 5 3 seasuuiEsIIEIaEaIRenIRIRaItIRITIILE ot itiot Sot - zZ & 2 E 5 Fiimsiionisumssscaniiiases g 2& | it : 1H3 87 lSEERREIEnERNENRISNSRTEiSIEiRRiSeSrSiRReSdEvCERIoRIRnNaAAnfEaiy CompanySaniizad. Doesnt contTSaCAiGnBI ~ 2Z| : $3883 2 2:: iHsaisd g jd = z fEinzmazestes H 3 RRANARAANAARERS : : 8 ; RER03R3A3RER i| i = Sagdiiisiinady i i CF IIT CompanySanizsd.DoesnocontTSaGAiCnBI ~ i 2 43 siesns 2 gi z Ie:=I) a oe 2: eRna zd aii dRsiRad i ig Fees] i By or 5! 4 gggsesszansssnacssassasspnssnaganee GompanySanitzad. Doss not cotTaSCiAOnBI ~f & --_ : 1 i 2 2s 2 a 22 5: EISNRIRATLSARRNNSRAARNASARINAARERNARLARNRLRIAR ArT TARAI NG nT TRA GRA eye ar gan (2 sonnmunmmmssnsnsnEnss 3 3 #nddnsedniadssdasdddndadedastesedasadninanes Z]El :32 it24 SFpp FiRdAdRRRRRiAgRiSiAiRiSaRiEiRsAaRrGrErAiNdNsRrAaScAiRaTrAiSiRuAsRiSnasniRsinssmoarsisssd 3 i 5355382352803 50350055050NE008R032NE3R03850 ---- | : 2 2& IEE z 2i fiiidrasnssssss ARGRARRNRAARIRR in3sagacas RRARARIRAR Boz8| i3 3 4 5383 8282 33008 8033 0082 0S00 33034 3283 5520 833 Company Sanitized. Doesnotcontain TSCA CBI z 2 3 HEBER 3 SERE2 : dg38s 2 Snnmmn : - 32 Ha = 23 2RREA 5 2 HER cama 15; 8388 3 oe | goa, aa 58 i} ~ if [RE HE a HH HH Company Saniized. Does not contain TSGA GBI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcyTwoixtihciOtnye Generation Reproduction Evaluations DuPont-5990 APPENDIX D INDIVIDUAL FOOD CONSUMPTION -= `Company Sanitized. Does not contain TSCA CBI 9H-02D47a6y8:GaSvuabgcehrSotnuidcyTwoixtihciOtnye-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL FOOD CONSUMPTION Critical Dates EXPLANATORY NOTES Day70 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Food consumption data collection for ats designated for reproduction evaluation (pregnant females during gestation and F1 pups after weaning) are reported in the Reproduction Toxicology section. Day 91 Last day of food consumption data collection for male and female rats designated for the 91-day exposure period. Day 95 Male rats designated for the 91-day exposure period were sacrificed. Day 96 Female rats designated for 91-day exposure period were sacrificed. Day 119 Last dayoffood consumption data collection for rats designated for the one`month recovery period. Last day of food consumption data collection for rats designated for the 3-month recovery period. - Day 123 Male rats designated for the one-month recovery were sacrificed. Day 124 Female rats designated for the one-month recovery were sacrificed. Day 183 Male and female rats designated for the 3-month recovery period were sacrificed. Footnotes a. Due to error, an inaccurate food consumption value was recorded. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extremis a `CompanySanilized. Does notcontTSaCAiGnBI ~ Of a o nenannues menacaavancasanincnevooveriianenare a 3 AaRdmiie ana asa f8in isdndda iin iffAnc SvRr riaa RneEa aErRT nEeo AnAn a NEe aEan RanEo rEsEn ae 2 RRRRRARCRRRRRRRRRAIAR ARARRARRRRAAAR AAAS AAAS 2 : : RR RAASRAAARNRAARRARAR AAARAAARAAA AR RARAARAASA 2 1 RASARAARSRSAAARR AANsNANRARARASRRAARnRRAASARS ~ 2 8 3 88:3 FSRAERANRAnRREAAEARNIARRALNANNAISESAGANNEL2RENTARwKIRAmRaRAaNAsRRRnSR | IE I) Sn REERANRNRiNERSERAA SIERRAS |' | & 23 3 RRAAARARAN|ASRNSAAARNESSAASARARREAAIRARSASEAR 0, FE 2 oHiY RRRRRAARARARRAARAANARRRAARAARARRAAAARSAARRRER 28 . g3 35835552 LEARRESITaany yRge seTt aseR nne nzy CompanySaniized. Does not contain TSCA 1 ~ 2Fa 3 ants EEEERFEEEH ~ Zi 83 EER f 52 gl 2 iig8: B: H3E 4 FRiRiRAAR sEREiREsREAiLA ]. 5d=i amma am sa 1i3y iE3 sarstasss dacs AnsgAasngs 38 FEESPIESIICSIIIIIRIsERIsRISSBIsIBaSSiaG CompanySaiz. Does ot contTSaCAiGn1 i - 3 BERRIES 8 RRARAAERARRARRNRARARARAARAAARARSARE & THRERSERERE RE R $ o mumIEENREIERGELE 5g : I ARRRSRRRRRRE ~ 2 : 3 3 fr8ARRYRSASsAR AAS in Adds dansdgNAL il 2 B2l 28 = A EE R GOBBRI RARRSERD A ARRB REN ARE RO AA IRA R ARBRRr fg 51 i .$ 23 Ho3 3 ~i goo 3T ARRiRnNRRAiSRnAaRAnRRARaAsARnAnRAsRaARRsAASRRARRAAaEARARRREAaA :gz ob ARERR RR ssrsssesszzsasersazesaseasaseacesas i EREEEiIcIISICgRESEISPECEESRNNES CompanySantzed. Doesnot conTtSaCAinI - :z vray 2a RERRE i _ 0i R843 A g z 82 Senn 5% i :i sas8R !Zil 2 JsieednAasanusadnieinseansaan g 2 2 s GEAHIEERR ig f if 422 oEFF dod3d9d2d9sanng0aaadsdasndtsnn EE 27 5 N EERUTIRTIEANE SILITR UP IRATE `CompanySanitized.Doss notcontTSaCAiCnBI ~ % 2 IY ARERR kon FRERAGRRAR SRtiindtanieiiitinats z TERRI & 2 So EIEmMINELNIIESERNGE zi 22: GIRRRAReRAASARRARRARSAASRANAARARAR , g 3 SEREN ANRR ARAA ASRSR AARRAARSRRRARSAS fd 3 1 Br mmmmsEshEnmEuLnnm |1 :: ARSANAASESSAAREAREASISAARMRARSIARER 2 BF AdRAA RRA R ARR RAR ARRRRARARRARA i ig 3 : 228308RNEEAENIRIRARESEnR AzRE Company Santis.Bossnt con50aGnt --~ 8 3 32 % 4% FR E en ~ 22 i 8 28 % . s 82 sad $ Hi2|IEzRa 4 in i - i 5 fdRRdasiide 8 i i i HLi onTREE H i it7 ~ 584) =&| 51sF AAEiaisanes Aa i 5 E BgEstEnR ssuasiTN asasSaEsNsEI RTansEiiTsRLE iEanin: IIIITIITIIITIITTIITIITIITIIIIZITILT GompanySantzed. Doesne conTtSGiGn1 . 3 ERASANARKNENERNRIANANARERS BAINIRAT IRSN2ALASAR CERNE SRE SR zg$i: 0 ERMMIGROSIEREN IIsaEga eI anioveE nsern TAYLOR SI da ~- |g is 8 pmEnEEDnEmwtms IF 8 3 EERE EERE & + e iEgz 3I 28 or 1 Ty 4R 9ntgnsnaE ceateeeaaA nnennangR anaacnnsaS tneraann ren 1 SR i}t ii: i ERR SES i 27 | suman CamoanySantee Gos rtconanTsoA Co -~ i 2 :3%: gz 22S & 58 : :: Frei" 2An3gA9t 4333 BOR 7 gA9eadgRanqnsaanasn [* aRiasiaid !| 5 Iv3aErRoAsRndniyindeRodsRaanse g g a, EEE 2 LE: 233 3 FpAeRnRmRaAsReARaEsRaInRaAiSeR 54 5 HqEnAaAeSsAeAeAgEnRs LE #FaidismAansdaaedsd 8 I3E3EiEEisEIEEissiisilisisissisisiCisssssst Company Sanitized. Dossnotcontain TSCA GBI ~ i RRR 3 RSERRRAANSIASAARNSARRAINAAARASRAARARAARAAEN 1 : EnTERRELRINNNNNA ~ gi ; 8 2 nveraivaneenaannnnsunasrarenesonnnsanannennse 2 RddRRddnssddasdddsdzdadnsdnddndagdansasdanessd 8%; RqetReaRneSnsRisResRscRcaRqsRssRsasAanEseRanRonRenaanTyaRgaEes | i2 iA BE; HI I ssoRnmHemRscEseAneRcenRcRrAAnSnARaAAvRRoRnAScRaSRnAsRzESaRAnRAeSrSLaAnARsRsARaRnRaSaAessS sense 2Hod 1 | HRA &EFI 3 FELINE 3 i agreuasanauEERtELIneIaIeEneneIIReIItEnIIETIie CompanySanitzed. DossnotcontTSaCAiGBnI ~ Of $i: Ea zi 2; or 8: dgxs 1g : i| +8 mTaTmTaniun 2& 3 SSiidsddinddnds Bl - ramamss ida A sgdasdndng ssasioaen 282gddRNRA inna CompanySatis. bos notarianTSAGa - AETRARATAREAIANANIAE i $2g3 m mmammasnsmITaanonn % s RIL: gx 5 - 8g 5 AB EIAM RIIRGEAEIMOIHIMRARRR ORNDAINNESORe ERm E " i 5:7 2|2 gEB:8 ngadnaguismadsasmnddn2smsdmddndamzdsLdinssuasnntnns gm pi 3 REESE 2 i e 2 i ow SEINEAEIRANENNANIANEASRACENAANRA ~ 32 oEEsissssssasssssEgnasasnsiiss Company Sanitzad. Does notcontain TSCA GBI - 35 3 33 pi zi gz: --a--E_-- ~ | 3d 4 3 avoes : 82 ARAN Hgil 2 gg 23 3 aanazddasisnsas Eg H & 3: A I snnnnasmnanm z Company Saniized. Donotscontsain TSOA BI ~~ z 2 {oEAR 3759i3SinInIiaasiiassnaessRTIAaest 5 sEdgisdsaddrRddddddddddddagaddidsasg sdssdtsiRisissnsdsiizsiiansaunaAte 2 3 ZRIIRSNRANNAARARARAINRANNIAARLRANGN :53 EEEEEEEEEERE EEREREE PEERSEEEEE RN - | 8 4 i 8Eh8 RRA Raneaaanawae : f | I Sr RRAAREARRRIRAIRANIRERNANANE |e 3 SRARAARAERAARAdARERR 2 213 iJ -- 4 i 3 sidddssididandsdidinsisssdvadaceds | ~ ig fr I sEssEgiegissiEssEssanEsisising [TS ------ ~ | 2 LzEi Ee g24 mReAeRnRa -- g8 2 54 g 2I i 2. or feo i ds mmm 8 mamananmamanaes HI3 muna Compan Sot. soe rt am5aGn - z FeeRATaRtiaiziiitiiiisatatitiaRainiestiennay } sesettittiitaizitistisadiiinanatidintinannaen I RE :i 3: ERINEERIRLSIRSRRERaEE - 8 % Bn 3I55aIIIIaIIan IIIa nse sans : 23 AREAASNASANRANSdRRENR IAA ndRe dg agAdAgiRgadrAR HE z3 22 : I 3 PRL N RravEMer een NL eeCnen ee R ETE Te Nans a neon Yas LL Hot 28 3 Saddsasizsdndnddngisdscdvsdedecanssnsdddnddss Hf ammeamnrannnmennnmng EHI 5 - 53 4 B3383333R0E0C REsRRURAsGRs0uNsSa0n 1 EERE Company Sanitized. Doesnotcontain TSCA CBI -8 z 2 g 23 52 E 28 - gf 2 8i 2i fr. REAR oma Adana re Aasdd cavenvanne RR4ANNRNRS caennanacn Adndiiddig 4 qavoreasy | ddagdnanas i gi or DE Ho: mmm H i i z 3 33 3 FieRAnSassRnRaRsksRainEgaasnea 233 2i i53 [REJ TEE Ere 2 ig Fa IRaAsRaAnAnRRRARREsR w RiRe saan aan --- 3338 4I oS EBEE Eni0 iss3 iii3 iEsi88 i0e3i0E iEgiRg3 RiiFnE oRsAg0 iEcEs33 s0sRaF0 g3iRsE0 a0s3i5E s2s5sE `CompanySaniized. DoesnotcontTSaCAiCnBI 9H0-2-4D7a6y8:GaSvuabgcehrSotnuidcyTwoixtihciOtnye Generation Reproduction Evaluations DuPont-5990 APPENDIX E INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA S60. -- `Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8:GaSvuabgcekrSotnuidcyTwoixtihciOtnye-Generation Reproduction Evaluations DuPont$990 - INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Critical Dates EXPLANATORY NOTES Day 70 Last day data fromthemale and female rats designated for reproduction evaluations `werereported with the subchronic toxicity animals and are reported as "removed from study" in this appendix. Clinical observations collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 85 Ophthalmology examinations were conducted on rats designated for the 90-day exposure period. Day 95 Male rats designated for the 91-day exposure period were sacrificed. Day 96 Female rats designatedfor 91-day exposure period were sacrificed. Day 123 Male rats designated for the one-month recovery were sacrificed. Day 124 Female rats designated for the one-month recovery were sacrificed. Day 183 Male and female rats designated for the 3-month recovery period were sacrificed. --- Any clinical sign observed on consecutive data collection days is assumed to have been present during the interim between observation days, and will be reported as having been observed over the period from the first-last day observed. Ophthalmology Evaluation observations and Clinical Pathology Evaluations are documented as Clinical Observations and interrupt the continuing clinical observations. All ophthalmology observations from test day 85 are those observed during the examinationbythe veterinary ophthalmologist. -- -- Company Saniized. Does not contain TSCA CBI ~ 8; g a E z g :82 22 3 32 Qz g4df2sp i8%2sg 24%8s olaass Jafagg glfass J2%Saes 2 ~|%& vyiii for ioy ioy i 4 I 3EE B& oEd& lR 2m R o&l Ri&n iR&mRi"2n % J 3 iE BE GA MoH hE 1 822 EaiTfEdEdETfRE BaEEdRE EoeaeddE REo5a0dE Gan0ldaEaiEd 3 g pith ih 5h i 5h i i, iSEEE R Baad RBaLad 3E 0d E B2ed R Bred BR aad R 05S 3$3 3 5 -- 33 3i. f0% f 3 f f f% 33 ELL. 5= = = = = = = CompanySaitze. Doosnotcn7t50AaGnet - 3 2 & 8 E 3 & HE . ie id 2 8 4 83 3 rE a3s 8 g32 2 7 agE 4 Z Ings Id88Rs SSa~u585 833288 Sglafiesd g 82 4 iod 33 ifpF GixE d 8 ou, dh, i iE iE ' 3 :& B#5%on5d3 FEoEn] L E8T6Td I3TdTd 3go83 ml aii enpls n srndii eat Sag Fran He fn 8 gy ifiily ri BEE Gar BRECNEEL UGE REEL HEHE BREE S32 Felis dN elIECis BME lIISNIR i gi Sef Bsefi) B5sdBRal sssd) Gsssdiidd 8 53 3 3 2 3 -- 23 i= = = = = CompanySaitzsd,Doo not cont75a0AiGn31 C 5 Ld ii iff : Hoa z & S83G9EE oSaufRgEE gr or or or gS o: og 2 2 om on 3 ui ul 1113 : | : fTeOT icn0 i8 d8 i i% 308J HaHImtHH ETiEleTO eI a i z CR HERINNIEER H RMoRe EEBL BBREI)E OE) C1 ZEgdddlcglll HRs warer gB5E| 34 dses 1 as sli HEE 5. eo xs 3 9 1is 23 $30% 3% 33 ~ 35 . ss zw CompanySanitzad. Dnootcosnan SGA Got ~ i 2 z 8 ::g 225 He oe Ze Suze Se fie De She De fe Be ~3 3 gd 523 ro 31 o1 1: 11% 2 f 3 08 r i& io8 n o@ nponi: g fis 1J8 E 51 ce e1l8e,nt1i8 1aa0nd fz fpfafziniimaieinn &IE gBtHiamindhd deand pa iapaidaa n oii eilnanaiiaring ~~ i Fx x = o2 xox xox x ox = [I -------- -8 = a g : Bite fie Ze Se Te Imaiin man Inaddts iz .. 8 iF i - g3 i 1i i 2i 4 ? Foi mon g 4d 444 Ghd Gf Gd iiy iB10 ;Gp 2Gp 2fp 2G39833i5s8 q$9f38 afgid3iiipyaf B Seo iBtBd BEr;m ieBpipnfiinciuTnEnEy GiBElnEN iGEIEuMhEnDS i g il El il i i HEEB IHR THE 2 % 5 % 8 g2 --~ 33 f= x = = ox = == CompanySanz. DoesrotcontinTSCA Gr g ~ i H ==< 3 zg 5 3nn Fnon nn Snel Inedile Ends nodlde REL z iF ~ | 8: 5 a 2 3 3% i: & & a TI i4 & a s HE & " ]$ Sp ad mmMe In oH In bom In In In | Shi dm hi Ln LE hE Bi iE 30% uf nd tn ale nl nd aR ade UB GE aE SR gh88 S2g1yigdaiiddlhy cdehliahly AcailElyls doginildl EcsrainliIniEd dCaaHlnld HoNnHAaLLl BtlhUanSl B12 nd Gad Read dnd dual ded Init nial 2g 23 3 3 2 3 2: 3 3 FE ~ id Fe = = x x os . CompanSate. Doe rtcanTSA E ~ 3iH <= z Z. 2 gs 03 3 3 3 2zEC 5.l3d8s I#8des I48des IA8des I48nsg I4s8s3ds la8ds 2 3 33333 3 ~ 8 4 4444{ 4 3 2 2 & 2 & 2 & Ki dF Goh oh || OE 2B3:E zIie 3f8mg Hoe GEE Ep BZ apd sd ad 8 3 ful $938 g38 dB diaii Caa8f Taff aed Calf sfd EEEpita h dy with i g $823 82ed i203 2$38 82i33 EH :2 2FF2 z _&255 iiz ..E.F oh hhh Zfes 31p 2I3Es ZIing dg 4 LE Lf aad apd af syd gdqf gao8 gd gf gent Taaife fiDaa iat Tag38 iTe23 u hn uBEG dihn Gh i228 $8si B88) lad 03% f of 8 3 3 FE F LBL.8 Company Stes. SoetomTAaO31 of z 8 % 2 ER z2 08 8 8g oss 2 Dian Dien Danes S28383030e3 Se2dds gE. IiL f3 y 1Ig ~ g2 fiig: 3 go =as GHdieod Ei5n2 4 808EBi,m dm p Bam bl om Yam IE @| pos an8 PINE 5 LE Ea Bf 5 Ge fon, in I : HH i Safad Lon 2g% 2 2 283 FLEE 1 D2 Gin i ih fa 8 2g8 oifEnaEgd BaEED baEIanDn d aEnN nnEaaGqfieodg BJo5z1i dad sbaiakd addahn IdasI ssaE nsa || HseIs phi 8 fF: og 8 od E ---E3H8 I= = = = CompanySanitized. Doesnot contain TSCA CBI ~ g2 2 2 = i. E i: 3: 3: g fi ff #% szafas snide 5ucfEnes Te fe ane Be g: 3 & ur gr iu 2LE Luu 22 EH az t 2 Tas 3s Bass Tyr ' 12 05< inoT in EL] mE FLEE oEo iii S| E Zs Zu hms 1:3,of 1d5 02%FE i m DEEi aOtDmE, BaBnEmEdb,4 1001uLd lied ! EREPELEER RIES i RREAEES EBEEE]BEHh iEH d ii hi a Hanh fifa SEEREE ERE gaurd i g oral seed Bansal HD ED EBSD HE ~5q5{) I iE i : g oF o8 E I. CompanySanitized. Doesnot contain TSCA C81 -f 5 < zz 2 g = EBfoofelSoe Se e Se e ie SeefeeBeee Sse Be E$esBe &z ~ zS 2. d S vi:i voiiri oi 1rip ozo iiid ol 18 1 ii i i i i ii i % go Ein aEs AEE 3 0g& 1841, fEiIio1t3f3 f ofindid EEE EEEREE REEE Popmgaiagaaanamy !d Hg EH HHa HLS Ea R HEn R HR LH H 5 2 fgregrouroeroaiyoe oer owdyovl gradi Hi$IR3I BIiRsfEi: E 5 03E8g3i $EosiEiE $ EoE8 sR8 o E 48 9 ~ 4 2 $8 8 EEE EEE 8 8 8 8 Fr ox xoxox xoxox xoxox x Company Sanitized. Doesnot contain TSCA CBI -3 E 2 5 a : ZS.i.lenseo.lel ie g 8 2 -- <Q Ed5 ERE$& 11 31%1 1 E 0E 2120 10 8 Hoe igi iz ELE & 2 g kbh pdads 2 i [EET JfLE2iRugLrEarEgRn i g! 38 50 5H aca i3 g gi30;38 8@8% 39 --~ 348 Feog woz o yes T ss : ompanySanitzad. Does notcontain TSCA CBI -% zH =. 2 i .3 3 8 3 3 # fF 7 i zz lfgdas Inss nse lsass iss sass dsoss 2 3 3 EEE EE EE . 3s Is 3s Bsc 5 rs g ` 2H oo Zig 83 Es zEEg Es EBs 3 j 5 fg 3E2tfy, Bg: B213 Bg: Ba8l3 Ig: Ba8a8% Bg: Mga8i% BEE H48a8e% M4 2 48 I1 g ail af al ool i 2 $s 538 gaz8 RAGE gaE gedLE gavas 3 ZFsEGEig5E88 ib HaDd h Hfeid di5 gnnd Si0185 BG DBB4I4ndLE afdpifl de #5 21g up dl ale up i ik i Bg! $3223 S5ef zed B58e3 Bed psed B3fsd JPi2E B 8 0 oLLL LL `Company Sanitized. Doesnot contain TSCA CBI ~ : 2 = a I g i g Fa : Hada Se je we g2E 4i : iiH: - gi i i ii 3 1g om Blin jue RRR RE Eo 58% mh 338% 8 Iosi3E, 1 I 8852 3 8 nila ait snd U2 fmf GH Fagg da i Sefiand Hdiefn ldga f| H g C5 2 Eadie edvridis edNNE g AEMIEE i gd HEREHEPH ETH 559 gifg ffi i 8 ~ 33 i= = = CompanySanita. Bos otconanT50AGr - ot z5 z= ga : iids ii ra id oS 5I i.m es 75%53N2g% gNg Agagp 5304eAetis , Se BR Thiee = --_ gsi Q 8 58 iESEE 4= 8 5 Ya Yass las ox 11 ' ! 2 S 0o5o f8 aonoso kaa oTT 3GEEI] ER HH HR HR iJoo2 forma foaBmyh EPRaAI 83 ES,isBEiefgfn}dEHahP ieEniiensd |oBf ltd gf Zipidee a ain 22 g! $5882 BREE RERaiEiis 58 sil 3 3 3 3 33 - 2s i= x x == CompaSr Dons tamaTSAO a :g a &2= = 2 SgZz sier 2dr 9I832%r 2l%hofe lffuFfm =Ir 2dr edor 2Isr 2ir 2 ir %:dur g 8 - |i x dl Sri: trio ' E508 REFP Ri E of of rooi foioo pofon yod VeSililhnE i R PiL l oE id | Foci assay Io Fepaitinbinipnnii Woda ETE Fl e2 rarF aroeiy einoaroun er 6 911 91 eh 2g ~35) 8 Ifoesoso 5 x 5 x 558 536 exes oan Coro Stns essti ~3 ; z 8 ol Eo. ih. Bub z2& 4 lp lr lees lge Isp lp 1RJNGHE 2 i - 9 4 & i 31311 11115 ; 12 iL 8 8 i8 ii8 o5 HoEsIoDdEa 1 fdo T gBany EEE ER |f E 2 Gi ieh pE ig THE 8 grdtatant il iritit, gfgl| GofsiF oapiHuuRp uEalliyIgEmfBEyIGEap asa5si8l84ll8d2 ceed beso FI CompanySantas. bos otonTasonco ~ J3 < z E g likes BBB 2 Hiianditlons Thsnnen faisis Jreidees z2 82 4322 :3 33 g3 - S 55 5 2 22 2 2 re sg 3s & & dE a 389988 dog ih 383 28% 28% | 8 BciHspwrhals Bnlhf aBwE Hoeine i 3 mEiEnngNiRReE S ndE nEEdE enaht JEZ C2 ER I jzrH ia icN TiceiHtE fGrifeREdE faiHpfedT tsd pGRipI tHieTer i g LR ETHEL FEHR EEE EEEIPHEEH 3 fs -- 33 i= 333 - - - CompingSaiz.Ose ot conTStCiAGanl |: FEE 5 & E zg z 2Sp.os03n%.33 g & STTVBRER 5 BH 88d SAWIIR EERRD Ln 33 SARBIIURR 3 gonund9 S280R g2 I 4 ~ 43 Ff 3i 3i 33 ; 3d0i8 .Hr iHr aii iid : gs 03 B=yf okuy odnei oH233 sl signi pan ani an 3 8 a3 iB3F aAlslp Aa: RiR. eGlEE V O3 fBoidugluess Pfiagtlitf fggofguivnistd ffigts i Zils sil EIifEkEy E156 CERT RITA I i B 8 3532838 352333 35233533 3hedi i Big 3 3 3% z i3 gg g 2g i5 : 88 8 --~ 3334 HE = = = CompanySantzad. Dosna ent750iA Cr z 2< & 3z 1381 #im hw 13%; 5,5 us Eoiiph bn HS im ab ~- 18: ia ms 5 2 & dadaers Ides SSGveal SEISeafich g 3 g& og eg -] = & 2 az2 % I 8 dll al anf ani fF iTUpEER SRE TEE etecuqnd 8 de dnith din dn bay SEEN RIS Fe 23 BE isde2id Bid Bsadfdl lassdliisi SE ZL. - 7 HE Is ~ 358 5. . . CompanSones.Sect amin TSAGl Z| 2 g aEo 3 is : 27 2% o :ls 23 i: id 3 dg SEL g= 3 i 1 g & BRAS RRANER S25aRTHNER SRoa28E - g $44 . g5 i588 2 a2 Bs E82 222 3 10% tame 3 3 Fao 3 E fummoi EF [3i33 e80 ET i 20g, u8bTnETNRlagEtigusar PBof S2 83EAEiME;EiiTiiSnn i: gi! sesdifdiRE) nl art Ram raz Bm, hm, B Baan n BL HdaSndy H mRNa0HlL 44i0E0Rnt CeCH EhED GfhiIEsNiaaSiy J fil la Bsseiifin lassddd 8. 3 ix --- 3iE8 ; 8 = CompanySaeed. Doss rt conan TSCA GBI ~~ : 2 z a z E2 . .Ieee 2I.ze 8lr, 7Id2se lise gIp 5Jsa8s8e%ss g ~ 8:3 4 Jiri i3l 82 vy FI ovioro%y ' PEGS 5i 3 ih af 2 syd i : i $3083s GEHEepREbiRhedi OBIEhR gDERhb4RHgpiifnH i:2 g2 1fgfgch? BopEe? EplopAicy oEpiOgep gitiihy fg) fteoroos soss oosx ooxsosx 23 i= = = = = = = CompanySantis. DosntcanTasoicno ~% :E 2: .%% (A 2% 8 gfER4E : SrSRBR SUSAR ofARRE SBR STAIIRR LR - |Z 4 2 ii Lilo 2 2 z EEN z i 5a%i,t 8an4i H4% o 8 5s:a4t5 4 i 2S 5, E ggiFk o0ho0d% gt00aeBaH5khi.y0 pe fGBdaE Ro|v RETdE li0Ra0EsBi3aEltda0Ed ii6tdE f$5 oe2 aEEEaiRiErE aBEiBrE aGtaendd aHlDy fRamd]}i 28 3 3 58 F IH 5= = = == Compoea. iron ~f : o g 3 g : 8a E: oe Se fhe 30 Iadee Bian Be S5fea3s -i $ 3 d 8111 11 1 1d, ' | 7 o7om,ofor jESHDIRTI E EBLII. EEE EE rfon B4 IPhLaEE RAE] 3 5. Hid BE ih fn He bE gigl SZig lEiHmHZin oite fii]e SEieAlt SfiEc)y C1C cBhAeLaEt i grid 830 E30 EEE) EEE 6D Gadd) i 3fe os: _ H 3 ETF 55 5 oz = 5 wos 5 EF CompanySaitzad.Does not contTSaCAiGBnI -3 & a & : 3 2g - E Ingfddase Imdssn fed IRiedsediiiz 2 - g4 $ 3 2 : Br2 3s. i B&r E2ariko= : 3g02 Efo f3z ,&, ZBzg, mZip: oklogo. fl I oEFeE fhfihih,m n4 gfaiiydg i ffri fgcE f ahi u z 3 Sfpuadpiiac fyiodse ofndd Sf3hieRiyd agf)d 94 S2 g dBiiln, JiiAfG HEiLl E EsisiE iiis gil 2 EERIE si alin stain i gi B2a35E000 Dededd Badd BaliReiRinad 2g 53 Is ~ 34 i= 2 3 go . - 3: - GompanySaitzsd. Doss not comtTSCaAiGnB i ~ & a g g: z 3: : i:oe -_ 2g i5 LE + 4 44 $% 3 23 HIn BBrioodn dhmonE]g 3 F, filed mind mitt in ily 108 HIE asiEa pGy e1d sdlE LaEl L4h SLE SRE Sadia Cal 0 Said SEpEESg8 SP895.3 5f3c8 e Sfp.8 if 43.8 Sl BF fEigggiisy dfagfy Shahin fain fheah 3 i g2 ! 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Company Sanitized. Does notcontainTSCA C81 : 2 iiE = 2 E: 3 :J zi ;z g oodadenidis De fe dice Ide Fie Ie %e Be Be ~ 2 pe s Sz fh ori o:o:oriiv : 2 e3 f agusmeddti f1F1 % ioF0F FE&EF o&8 i2 LENE EEE | 2 imi mE Las }: FlEinEn aba hi Hl igyahhy $I gts aiftl ininliey 4n23n1 4d0 0 if i fat u shdhaaas i: 1 fasnraeed i HadbliEingg EL oo ~ 584] H . ST Ci eoo e oe sC eR l oD BE ComporySate. ous cominTSoRGn | H 2 gg : : Ed Je Je i%e dr lp lr lp le le lr dp Raul z 23 i: ~ |g % IdS-ErErEEo EEr EEEi ERE, ' 3 3 % EF & E : f & E GZ3% Pe iid ERERRERE 30S ir8r53d, e8a3s%s: 1a34s33s anfif dFoOZg GpalbpimfsEisnfsBisEisndsfsafelfelDaahg &3 Z3s% ia1 AeEr IaCiEr BE1 RaE1 B9E1 2AE3 241 063R B9E 9A0F SsEhEiCiid i gil gutRunannide incf8fsf iEiEiile LE ---- |: z : 22g g 132% 32% 182% 132% 130% IN0 182% 138 J3sgesad : 1 a u wu u wu uy 2 g Id min bland by In In IB8RulEulEul sRnlRaBd adER si a5l Laibi i 2 Pfu rd het HH HH find gf 231a iRE]midfaebn} idpiemfd dh fabl idfall Ret dl I GpiEel dfied iHisliehlls 2E23225 lad dnd sad dnd Baad Bad Bnd Bod beennild CE4W]3 o2o3b0e%eifn.e 3 .8 .8 s efL os fLs e oLfe f 8 B00 0 LL 0 LLL Comm, Some TSAI : ~ 83 2 3 Qe PE HE 32 2 i Spas i st ax 30 Gx 33 wd Add EZ 23988 598% SS8X 390982 98338 L928%RAER - lg iii oid ; & gy oy 5s JgES ouE, oEu, onE,RE on n 8 nI IIE II 3 EOSF 3II:E 3dI3uE: Ziz da LZHiE:dL zLBiNsa, kiBssL3 9 ed si eid ni gE id 8 2 5iTs58E 2475588 2a2fd fUiigEtl GfggigRd if HpifEvl I nBir nHI i 035 t HEEL i HINER iEfn MLG Sif 3giP[aEFdI aFELlIS aFElElS GFYFHE GPoEEE u FLEElEH 1% : i EH 3 3 g 5 =z z 7 2 7 ~ 85 Fe os wow . - Company Sanleed. Goes otcontain TSGA Gal ~ 3 H z a is z 8 SS83R S988 SSBR 098% SRoant SRACARTNARR z 8 z ot - g ff fF EE 2 Bog Hr dm ol lla los 4 EER EOEEEL BI 388 233 ol288 3ELi8g 8E Lm 223383 Oo& 3% nl ul oad slog aignliln | 2 aTe3aritF gmeEd neagnF guedRg1gAaeRngdE mgaRninsesiialg 3 &. dni hea | pE pit SEER ho i ERLE i 8! $5028 $508 820d 3208 s2af lmsasaaill = HH 21id 2E 2 02 E] 3 HA z&2z 2 ~ 33 Fes ee. . CompanySaritzad. DoeotcontainTSCA Cl ~g H 2 = z gL 23 ddr da fia o FETRAT Id JSST oe om zoe 9% 2 EN SRUSAIE SoaBR SAcRRIE SR SR oR SR SR o3R oR g 1 82 sf 0si Bei : fond fy ht 10E1g E| z 19 ii iy i i i i i i i i Sided 0% inl hsing domiptdos4os4o0xod2 dox aa d Ha338 gSafg gEEAEdE fog ff, gif FERREH HR RIB RIE BRE gf Zipline ag ii i il i i g: oaresd Basdd pmpdii dl ML AR EN BD EMG b| HN ~~ 33 5. z & .- ZB BOR EB ORB "a ae ea ow Company Satins,Gossett TSA! i3 2 2 E : B iu2le%se l2r I2%ie l2p l2p d8 p l8 e l2 e lep [d2a8s2e lp 1l2aw olfs 82 - 3 2 d $3 1: oriiiiiyoiiol ; 1sl2 1 PoLbpoLfioioEfnofoFbioFonf RETR RRRRRETRE 1I8ELE i ESE8R8NE8 EF RFEd .BhEi EEEE.L Joanna ann 3KI2EGL al 1HiB3% FE 97 dd 37 FE IF 009% EE 73 3iY 15 2 ~ 33 i. Z 2 RB RB 2 BEB OZER Fe ee ee see ew 25 "ew Company Saritzad, Dos no containTSCA GBI ~ 5g: 22:10: i5 ia3 ?: Bode Br Bile Gil ad gZ 8 & & & & & & & 2 3 2 3 2 3 3 2 . ~ 2 5 4 5 4 2 g 83 5 3 5 3 5 5 ug I dFsSahhih h ayiithhb 5 588 S88 353 8% 38 3 a8 3 EEL 5i HE 2i 88ggaBhn CER i: g! S508 i$5 gi23f1% [EI EP 2Ei Ei2982 i Hn dHHE EEE ned Bmed) 13 i EI HR 2He i, 29383 ah, 2gifs He 2ghd EHGE GHEi HHE h dH EE ned Bnded) Bndedd fsedd O%E 32 3 3 Be + + ss x 5 - 23 5. " " "" " " CompanySantzed.Doss no contain TSCACE! ~~ 3 2< cs : 3% sii 53 doa E2 J sss ous Drews 53%agfen Siaiimsdest 2E .i .i g8 I #Ep o=u ifax laf af gi i 30%3 BGEh.iogoEhY Eomgognr J fo i % oA5n8l82 duall Sm53df foxaRned 9maiplp3iy Ho2 fd af el eel cing 8g Hm HE Hin HEL Hh & Of dfis5y SE4% SEiq3 S5Egsssl S fibensncd LF 2 Elie adi gl lIEIER g BECCCR i g! redid Isak need Isedifil J mssdifiyd 32gg 52 = 5) is sx os 5 --_ -aL Le . GompnySantzed. Donoeconstin TSCA Ca ~~ 3 H 2 & Sus HE gL & % i GL : Fr 5 Sigg z B 58883388 5433%0438A8 dled Ise le lar lor 3 iE i i Veja ma dima gd 3 iE ai 1H 1111 P | iTmigmus isde hn 3ffmaa f1 Io IdZ E Byfii fdiEas.cidEs Bs fF 1H f: |o3022 f 1f grifya ryyes iS pptg Ea i gM f2iS igtptgg h 2a m 02 02ti4ay of BEER EERE ULL ggEEHRhE ia inBHTLR UiiRi E HLiEULEER ELEE H Zz 3 283 amrl Deawdn aund alHE ERE Ew 55 3 3 EH i2 . ~ 35 5. - 3 2 33 3 ss sos os " " noe ow Compras DonoAOAGE "4 2 s 5 &: _ lz : 2 lA r de dz Iolse Ilze Ize lee lp l3e lp lp deme g 8 3g 228 Tp3p1pYooproopooTfooBiEooGpiiii : 3 : iF Fo: BF i iF ii iii I} P11PR6fs RfL f B GiIhRiD lis EERE EEL ERE REE: gi 20 HE Gal BEE EET & 902 EGskh ii: i ii b HER l TEH aild hin HH i i d Fenrir iii rian CERETE EUR ERLE EL ELH #83 ~34 E x ox oy $= = % gr nn 5 # FF ae oF 5 5 uw Gompany Sanzad.Doesnot contaTSiCnA GBI :g ~ 85 3 5 a ERR 3zz dr dr g 82 --_ 2 82 3113 3113 3i] 3E : : of 44 IZ iE 1 6; 11 S dy i id 3 2 2% 28 2 2 I 3 fathan 32 inn iEI ZiIdisHaig 3 ig CC C7 5) Es sx 5 os "Ee. - : Company Sarbzad. Bows et coma SCAG ~ :: : ; g # suds Ssmdasiss Jsddnds IssdiRn 2i i 3 i gB E i i 2 gm won Boz gon Ep Ere Hs far 1 aLiilkgBlE LgEiSll SLEhL 3 fg HE eat et 8 pnd ahd ail ahd HE BE3%y fifss5388 85345458 E3444 2Z3| 2 FER EEAfI EHEEIEIE NNEIEERHIENA:MHEEE:L 2 gs Iraih D3BEEEGEl BnedEE3) IsedEi a4: gi1d3 3 3 3i ag2d f5 F "i ~l os. " 8i - . Comp Sri, ees canon 8 5 3 &: FA bE had ZE 3sisizaciiets Isiscatdsss cacss Issinsg s - 2g 4 3 3 3 \ gi i i & 1i 2 HREi 3ii5 BoIa E 3 ak 2 28 at i g 2 fapgubliEnlEgid LapEliEgEi,flf LaaEd] Hadhel 2i S3 H$aaclllilRHSE4E8 HguiianldShRidal H6E5I8R sRadi8 4 EB, iEAlEG LBHESL Gh DING Zedidilh ani Hh Bh SEER ri THR i Bg! SedediiiEiaa] Dre dREEERAEY Daas} UaodEEY iHE ed id ~ ig ie : ioo i " " Compiy Santzsd, Doss motconanTSCA CE ~~ % 2< g L : . I. da% 2 BLE und Ged Td 2 & Ionadicasddenads oSalataatiodnis Soiiid Vo pi lh Be da 2 ~ g3 o;i :i iii 5 1 :: 3eWsda ii5H a Jkr iF iii. ra. id oE 13 Bpiibls 2 Faanghs. if aiial, 2gHPAREES 3 Bie fypa J 372 lie BLiddsdddsgasdny gre fLTgddaiasaasny Hi 5 i gs LE PEEREEEFEE EEREREEEE ERE HERPTHIT i Eid i : ~# 5. . . CompanySts. Snort conain SGAG1 ~8 : 8 E 3 5 $3 fi g $ : 2 ' 3 13 = & oNRRSASNANININRINA2N SNNSANAYASARN SHAR 2g 3fy - 22 i41 3i S dds, 3fy 3fs 42 s43t $ 1 ii Boas : dd $358 ] 8 FpEueaais oq 7 p5.35n3 g p3938n41 | firnsgd Bold ar Lipp MR dni =i : Junin Siggpiisasas Bo 8 of mul 23, 85% al 132515 I3 25, H Hi il gl a Te aafh H Hiill ] nHIaLLiS S| #3 Of REEEiiiiasiay 2 gddddaaiiiiil igng iginf GSiRfIiNiSgIiIzCiCzH.Ed stilfliEiNd 34 BY esssnsii A EI Bosdial aan 13 21Si%s i5 ~~ 3- . " Company Sanized. Doesnot contan TSCA CBI ~ 2< gE, : Gas zEg 5a0desd Jase Jae las lxe lfse lie Ir ik CE 8: iiE. ) - g SCI BE or 11 o3oyo1o1 :: 11 :9 fi5ecsd fg ii8%4 4g %g fH i i8 3 Is, 3314 0% % 2,0%82 | gof5m:g0 P[Fi0d00ag 00 E Gy E iiLl ERE sallsl EndY af NaENoTF a Nof EsaR BHI HE Bl He HB Es f ge dni DARE DE OE SE BRE GEE SEE EE EE il i g! essdfid SLL BL BEL BEL OLE HH if . 2 if -~ 35 5. Ef: Ff of fd LLL EOF OE BOE OE EE ww ee we wa CompanySanitzed. Does notconTtSCaAiCnt ~ 8: H & ::a Boe see emt are eee ae z le lzaaae J3dAaze Jp lode IaiiAlise Inge 2g i] g 11 3 Ty 3 1 $: 3 : :i8f 0 PirEE {{ 0E 5, owio, ii, i0, 1, || EFhfdanbaoadrEd: [oloefl 5 gi LE0ad 4fl o82 f fa f Hi u i ELgL hy iaLi l hi iee fh & gop BEBE REE OE BRE Lo iaet aed 5 2i i $8386 2888 0 ii ine [H H FEE RR. E .REE RI R HEE sRH _ #24 52.3 .E CEl e. . CompanySantas.Doesotcata TSCACEI :: 5z 2= 2 z : E EF diane de Jdvde lose oJdndlde BelidisE 8Z 3 : < 2 g3 33 33 3 * i8 22di iii i d 1$3]3 PEig iign i,0 | E 8 yp r IEEE ge bhnee U2 fh ii an in Gait BBE PEP REE Ret 1 31st g diy fh dil RHE i g LEECH BI EEE FHIEEEH IEEE P3 H fs= ~~ i ie ir won fotwn ni "ow "- - ConsSot. coeranaTSORCt : - Of E 2 a g: =i s5gg fected Imcessd 3andis Bnew Fmedilils 2= : : == bo - ) g8 oi4, on, oani, wnF,E ou 3: 1i0 id p#3omEl $md nil (RE falery fRx BTy Gili 4fal sGiiladdi, 3 hihi ali GHM LE Gan ! g . Hitt HID BEL Bh ln SH$ 2 E8RsItS sShhanity sSiingpin daiiyf Sdiiaaginiy i 8! 5o30% Bado3i) Bnedf3R Used Baediid) ~~ 3s ie " w "" CompanySantzad. Doe otcontTSaCAiCanl ~3 i- El g3 ~ | a8Ss i&u uv $M : gf ff : fom orl dir S 0ip LdBiEEn ifIoGipE,hy IGInnE d ui ad oa 4h ig 3 GHiud gHuin fHH ofurang nHan i 3, qe pe fd bin 5 21 3fhcs gic: gniil oli: i g! 520d Bred B3Biedfil Bnei 1I ~~ i. : . Contant, rastcomToR H-24768;: Subchronic Toxicity 0-Day Gavage Study withOne.Generation Reproduction Evaluations DuPont5990 APPENDIX F OPHTHALMOLOGICAL EXAMINATION REPORT - Company Sanitized. Does not contain TSCA CBI Jsos Rl Eons --_ NANCCYMo.mBReOrMBoFEomRRGa,vViaLats.4. roses os Duron 090 stunmvrormaTion:sesey No.INN `Species: Rat SUEMACKENTIE OPRTHALMOrLOeGmImCsALuEDXosAMIoNsATbIOtNSCMMARY Te S o ga as METHODS: Indirect OpbthalmoscPFEoprheytofoealalotcwiandgo1e%sTeropnica0miDde mydriasis fae cGas FF ete do epl ro0nD _ ocomymomTrshmoIessCuswSeIeNaieihpkalmorcopc on thre 0)maesnd nc rt dTreiamsr faehct et,pBss soib.cTorolnoriaobpiidrtoorenmceathnee goebdeioee ee Seen wiretele, NS ader h2eGBrieg, Vlise4.tho Fo paws _-- _-- 85; Company Suited, Dos notcontainTSCA Cl