Document ym02mVQyDRqV2ML9495jZ6Xr

Fc-1z9 lo Submitted to: BIOSEARCH. INC. ptoe. lbeoxp8h5o98neph:iladel(p2hi1a,5)penns8yl4v8an-ia441991091 Project Number = 77-1127 334 CCeonmtpearny Ssts.io1Paul, Minnesota Material: Sample Received: Date of Report: Test: Object of Test: Method of Test: Results: 3H Company ~ T-2001C0C 11/21/77 Study initiated: 11/30/77 Study Completed: 12/6/77 176/78 Primary Eve Irritation Study = Rabbits wThoicdhetetrhmeinseubjtehcetdemgarteereiaolf miaryriptratoidounc,e wihfenany, instilled into the eyes of albino rabbits. aTnhde mienthtohdesgreamdpilnogyeodf inthethetesttestmiantge,riaelvalauraetitohnose danedscrAirbteidcleisn, SAedcmtiionnist1r5a0t0i.o4n2 a~ndHazEanrfdoorucseneSnutbstRaengcuelsat27ionSse,pteFmebdeerral19R73e.gister, Val. 38. No. 187, P. 27019, The somple was used as suppl fed. Siinx thhiesaltshtyudyy.oung0.1adumlltofalbtihenoexrpaebrbiimtesntwaelremautseerdial wwahsileintshteiloltehderinetyoestheremraiighntedeyuenstroefatetdhe totesstervaenimaasls ctohnetreoyless.. The test material was not washed from T5h6e 7tredaatyesd efyoelslowweirneg eixnasmtiinleldatiaotn 1o,f 24t,he 48 & test 72 hrs. & material miandteo tihneaceyceosr.dancIentweirtphrettahetiognraodfingthesysrteesmultosutlwiansed 8iyn Htohezar"dIolulsustSruabtsetadncGeusi"d,e for Grading Eye Irritation See Table 1. 000184 3M Company - T-2001CoC, Primary Eye Irritation Study. Conclusion: mBaatseerdiaoln the accompanying Is not a primary table, ocular the subject Irritant wSietchtiinon th1e500d.e4f2ini(tb)ion(1)of (2t)heP.Act2-7R0e1f9eraenndcer:equires no cautionary labeling with respect to that section. DiKarrelctLo.rGabriel, V.H.0., dPh.D. 000185 TheLE 1 Grades for cular Losions Material: 3M Company - T-2001CaC, as supplied. BEST COPY AVAILABLE 1 hour 2 hours 48 hours . 72 hours 5 days 7 days Babbit No. 3 32 45 6 23! b5 6 23! 6i5 23! i 65 23! 5i 6 23) 53 6 arene ris Dpacity Area 0 00 0: 03 0 00 0oo0 0 00 00 so oo o3 __Conjunctivae Redness~ ChenosTs Discharge 1 1 3 !1 22 33 21 2z 33 1 2 3 .01 0!1 :2 0 0oo0 00 0 0S 0 00 0 0 0 ;00 o >0. o30 20o 0 0$: 000 o s oo s o o: '20 :2 o0 o oo o o0 0 0 00 ooooo: S: :: 00 00 00 00 00 0 00: S0o A o0 200 0o 02 0 o o o0 o0 0 3 00 0 0 003 o o FA o o 002 009 g0: 00 o oo o 00 0o 00 0 00 o 0 0 000186