Document ykkKGvepd7kwnaVXYM5ag07M6

3M Environmental Technology and Services PO Box 33331 St. Paul, MN 55133-3331 651 778 6442 May 10, 2002 Document Processing Center (7407) Office of Pollution Prevention and Toxics U.S. Environmental Protection Agency 1200 Pennsylvania Avenue NW Washington, D.C. 20460 Attention: For Your Information Docket - Docket No. AR-226 Re: Information on Perfluorooctane Sulfonates and Related Compounds Dear Sir or Madam: This continues 3M's voluntary submissions of data on perfluorooctane sulfonates and related compounds, as part of our ongoing dialogue with EPA regarding fluorochemicals. Enclosed you will find the following supplement to the Two-Generation Reproduction Study of Ammonium Perfluorooctanoate in Rats submitted previously to the docket on April 2, 2002: Final Report, Protocol 418-020, Argus Research, Charles River Laboratories, May 1, 2002. The enclosed document describes in detail the covariance data from the two-generation reproduction/developmental study with ammonium perfluomoctanoate. This analysis was undertaken in an attempt to understand the degree to which certain effects seen in the F 1 generation (delayed sexual maturation, post-lactational mortality, and increased estrous cycles) could be explained by either gestational age/maturity or body weight of the animals. We will continue to provide information as it becomes available. Please feel free to contact me with any questions. Very truly yours,/','_2"_---7_-, Michael A. Stintoro Director of Environmental, Health Safety and Regulatory Affairs Specialty Materials Markets 3M Center, Building 236-1B-10 St. Paul, MN 55144 651-733-6374 (phone) 651-733-1958 (fax) E-mail: masantoro@mmm.com Enc. cc: Dr. Charles Auer Dr. Oscar Hernandez