Document yb5krKL9Danpp3VR5NRD930y6

r : r> i -i ! ; ..... ili'- clinic ll I i.iid ings were charact i r i n i ' of ..... Invi'i n- at ii to 1 i i right ni'ove Cir.- Inngr,. the resp i ri t " rv .-I'. i).. : i. I. Tlic clinical d : agnos i s ir.-i:: asbestos.is and 'luoiiir i i.i: i ;|.r: ."i i.. with rind (nkiii) lo tlic bottom rip,lii. In .1 I -.1 i 1 i on :n .1 .11. ; 1 i - i;i with r i fjlit lateral pl.eurUis .and bronchj.t'O.tnsi s . .1 J.jam- 111 ,..l e.-o. i : '.is found ill tlio right lower lobo through f i.-i 11101 u;; i 1 .11~.ina- i":'..ii.il v.'.m ii uni. ion , which wii.s mneroscopica!1y taken ns t uhcrcu 101 i s . ('i.iy through tin: microscopic cx.yminat ion was it possiblp to detect cancer [ 1 hr pavement of the epithelium. There were no iiietast.isos to he observed. Il in umiMi.il 10 .*: i' ...I k of .s i i:u: 1 t ancons liya I ine nodes in the lungs of nu ll t v 1 on i s patient.':. The eareinnma originated from a bronchus witb a mot.a- p'.-iMi ir epithelium. The authors Celt that thi'.i had been caur-od by chronic irritation of the hmucii i t. They spoke of the correlation between cancer and ashestosis as a "nnssible relationsliin" and tried to find parallels to other occupational diseases of the lungs. In W36, liglii ri and Ccigor (USA) reported on an additional ohsorvnt ion which they felt was the first one of this type (with the exception of Ci.oyiic's 1.933 report). The 41-year-old male had worked for .18 years as an asbestos weaver. After 9 years in this job, he had a case of pneu monia, followed by coughing and shortness of breath. Eight months prior to a short treatment i.n the hospital, lie began to have occasional back pains. He was emaciated and had trouble moving because of the pain; lie coughed, had cyanosis and shortness of breath, as well as bloody and puru lent expectoration. In addition to ashestosis, x-rays showed a cluster in the left bottom part of tlic lung, which had the appearance of an ate lectasis or a pneumonic process, but which was recognized as a tumor, due to tlic fact that metastascs were present in the pelvis and in the spinal column. In addition to ashestosis, autopsy revealed a 5:5:4 cm acinose cancer in the left lower lobe of the lung, which had caused the appearance of rnctasenses in the lungs, in the loft lateral hi.lus and aortic glands, in the right suprarenal gland, in the abdominal musculature, the pelvis, the spinal column and the skull. The origin of the tumor was formed by a large secondary branch of the left bronchial lower lobe. Uc felt that lliere was very likely an etiological correlation between the two diseases: "That the irritating effects of the inhaled asbestos particles may in this case have been a significant factor concerned in the development of the primary lung cancer seems sufficiently plausible to be worthy of considcration." In 1936, Gloyne was nhle to add an additional observation three initial ones. He found a non-differentlatcd carcinoma of lower lobe in a 59-year-old male suffering from asbestos is, who tor 21 years in the asbestos industry. to his the. left had worked In 1938, Sparks, without specific data, stated that in hin autopsior., Cl, 1 y 111 had encountered 6 cases of lung cancer in patients suffering from ar.h',s( nsis. dander learned from Cioync himself that those 6 eases of can cel were based on 50 autopsies. I11 the same year, Nordmann provided us with two new observations of cancer eases in ashestosis patients flint lie had previously and consecutively -3-