Document yLQJrVn47KEBnn2GDBDK3xeV

bo VOLUME 7 NO. 2 PUBLISHED FOR THE PEOPLE OF THE PAINESVILLE PLANT Painesville Plant First Half Safety Award Acts On Program Completed Vinyl Chloride Problem The first half winners in the. 1974 Safety Award Program have all been announced following a drawing in early July In January, the PVC industry, including our Painesville which completed the awards for the first six month period. Plant, was confronted with a new and serious problem that has very much affected our normal mode of operation. At that time, the B. F. Goodrich Company announced that vinyl chloride (VC) exposure may be the cause of a rare liver cancer, angiosarcoma, in some employees at its Louisville PVC plant. The announcement has triggered an immense effort on the part of industry, government, and labor to thoroughly investigate the problem and take immediate action to reduce employee exposure to VC, Currently, 19 cases of angiosarcoma have been discovered. These diagnoses have occurred over a ten year period among employees who have had long term, high exposure to VC. The Painesville Plant can announce at this time we have no indication of any cases of angiosarcoma involving our employees. The purpose of this program is to promote a constant conscious interest in and awareness of safety. Obviously, the primary reasons for safety consciousness on the part of the employee is the well being of the individual and his family. The avoid- ance oi pain, inconvenience, loss of income to the indi vidual employee and his family is of major concern to each of us. The Com pany's Safety Award Pro gram is an additional incentive through monetary m winner or $2$ s**ngf gifts, Couumjea On Page 9. eood. New Emergency Crews Near Completion Of Red Cross First Aid Training Sixty men have completed or are nearing completion of their training in the First Aid and Personal Safety Course being offered in the plant by accredited Red Cross instructors. Instructors in the 18 hour course have been Norm Walter, Plant Safety Supervisor, Mike Nahorniak, Fire Chief, Fairport Harbor Fire Dept., and Fred Armstrong, Capt and Training Officer, Painesville Township Fire Department, These training sessions started last November and have continued until the present time with the volunteer groups Continued On Page 3. 08662-1-F Epidemiological Investigation of the Polyvinyl Chloride Industry in Reference to Occupational Acroosteolysis .f'//" Jet'' 'Jr V& iA \0 f* by c/ The Institute of Industrial Health The University of Michigan Ann Arbor, Michigan February 1969 Confidential Report to the Medical Advisory Committee Manufacturing Chemists Association UNIR0001470 or elsewhere, followed by healing after removal from the Job but with per sistent Raynaud's phenomenon. L, Reactor Scraping This Job appears to be the greatest single factor in the precipitation of AOL. In the overwhelming majority of cases, a history of work in this job can be found. In some few cases outside this study, AOL has been seen to oc cur in maintenance mechanics. The cleaning of lines from the reactor tanks may afford these workers occasional exposures qualitatively similar to that of reactor cleaners. 2. Compounding Operations No definitive cases of AOI# were found in operations involving compounding or fabrication of the finished polymer. Neither was there undue Raynaud's phenomenon occurrence-in such plants. The relatively small population involved (i.e., 557 individuals) does not prove, of course, that the disease never occurs in this operation. The one questionable x-ray (Dx Cat. k) seen in this population is not unexpected in view of the common occurrence of such border line x-rays in the control population. F. MATERIAL EXPOSURE AND AOL 1. Despite computer assisted comparison, no one compound or class of compounds clearly or exclusively was associated with the plants having AOL in comparison to plants without AOL. 2. As regards Raynaud's phenomenon, there is a possibility that exposure to vinyl chloride per se may precipitate a response* While it is understood that the exposure to vinyl chloride in such unique operations is minimal, nevertheless, the rather unexpected higher Incidence of Raynaud's phenomenon in Plant 0 is noteworthy. If this turns out to be the case, the implications for the etiology of AOL are obvious. Accordingly a close surveillance of VC monomer production population may prove valuable. G. WORK PRACTICES AND AOL 1. Recovery Phase The use of a short period for recovering unreacted monomer from the poly mer might lead to more residual monomer in the reactor (e.g., in voids of PVC "01 / UNIR0001471 residue on reactor valla). A study of the temperature and time characteristics of the recovery phase in several plants failed to show differences In practices between plants with AOL and those without. 2. Air Flubh of Reactor Before Entry of Cleaner While operating procedures have been established by plant supervision, it appears that these are being shortcut by hourly employees resulting in in creased potential for exposure. 3. Reactor Cleaning Procedures Hand scraping of reactors has been practiced in all plants except one that started operation in 1$66 and which has always used solvent cleaning. Among the seven plants with AOL, all hand scraped the reactors, generally after every batch, though one of these started using water Jets in 1965 and another cleaned a portion of the reactors with water jets from 1962. Among the 17 plants without AOL, only 10 hand scraped the reactors after every batch and one of these changed to solvent cleaning In 1965* Others manually cleaned reactors every 2 to 10 batches. The plant that started opera tion in 1966 with solvent cleaning has had no cases. In the two plants with questionable cases, one hand scraped the reactors after every batch and one after '`several'* cycles# The latter utilized solvent cleaning intermittently for a portion of the reactors in 1966. Size differences in plant populations between the "positive" and "negative" plants reduce the validity of meaningful comparisons between the two groups as related to cleaning methods. Use of high pressure water jets and solvents for reactor cleaning greatly reduced the time that workers were inside the reactors following discharge of the batch and also their contact with materials remaining in the reactor. H. CONTROL MEASURES IN PREVENTION OF ACR00STE0LYSIS In suggesting control methods, it would seem in order to reduce exposure to suspect materials even though the identification of them as the causative agents is not conclusive. Decrease in the time spent scraping reactors could be accomplished by more extensive utilization of high pressure water or sol vents in cleaning procedures. The severity of exposure of reactor cleaners to vinyl chloride and also of personnel on the charging floor should be kept at a minimum, desirably below 50 parts per million as suggested by Torkelson et al.'^ 102 UNIR0001472 rather than merely below the current threshold limit value of 500 parts per million. To assure that atmospheric concentrations are below this level, air analysis instruments of adequate sensitivity should be used. The flamrnabLt: vapor detector at most of the plants gives a positive reading only down to liOO to 800 parts per million of vinyl chloride. A more sensitive instrument of this type is commercially available that reads to a tenth of these levels. Also a portable gas chromatograph has recently become conniercia lly available that has even greater sensitivity. Both of these instruments give immediate readings of the concentration present. The current practice of venting the reactors by means of a portable blower placed on the charging floor with the vinyl chloride laden air from the reac tor being discharged into the general charging room atmosphere may result in excessive vinyl chloride concentrations in this area occupied by the reactor operators and others. Since the odor threshold is kOOO parts per million, freedom from odor does not assure safe concentration. Certainly the concen tration varies greatly depending on the enclosure, general ventilation, and the number of reactors being vented during the day. Air analysis using ade quately sensitive methods should be conducted in these areas. If vapor con centrations at locations where personnel is exposed are above 50 parts per million for any appreciable duration, consideration should be given to provi sion of an exhaust system to remove residual vinyl chloride from the reactor to the outside of the building or to a vapor recovery system. in' UNIR0001473 SECTION VII RECOMMENDATIONS 1. The association between reactor cleaning and the occurrence of a,L is sufficiently clear-cut that steps should be taken to minimize the exposure of workers responsible steps may take the form sf substituting vater-jet or solvent cleaning ror tne present hand scraping opera tions. Where It is necessary for workers to enter the reactor tanks, sufficier.*, ventilation should be provided to reduce the vinyl chloride concentration below 50 ppm. 2. Because of evidence that the disease AOL affects bony structures other than the phalanges, and because of Information made available by other investi gators that there may be other connective tissue Involvement, recognized cases should be removed from further exposure and should be examined at intervals to determine whether there is any progression of the disease. 3. Attempts to produce the disease in experimental animals should be continued to isolate the agents responsible for the disease. V, Plants that bad no cases of the disease in the present survey should Cnot assume that they are immune/^ In many instances failure to demonstrate cases may have been the result "of the small number of employees exposed or limited experience rather than due to a difference in practices. Because of these factors, plants that do not now appear to have cases of AOL should per form regular periodic medical surveillances since this study cannot predict unequivocally that cases of AOL will not occur in the future. For the same reasons, it is recommended that all plants, whether or not they have had cases, adopt the practices outlined in item 1 above. I I I UNIR0001474 SECTION VII RECOMMENDATIONS 1. The association between reactor cleaning and the occurrence of ACI. is sufficiently clear-cut that steps should be taken to minimize the exposure of workers responsible for this operation?7 These steps may take the form c:' substituting water-Jet or solvent cleaning for the present hand scraping tions. Where it is necessary for workers to enter the reactor tanks, suffici-.v ventilation should be provided to reduce the vinyl chloride concentration beiwV 50 ppm. 2. Because of evidence that the disease AOL affects bony structures other than the phalanges, and because of information made available by other investi gators that there may be other connective tissue involvement, recognized cases should be removed from further exposure and should be examined at intervals to determine whether there is any progression of the disease. 5- Attempts to produce the disease in experimental animals should be continued to Isolate the agents responsible for the disease - h. Plants that had no cases of the disease in the present survey should jiot assume that they are immune^ In many instances failure to demonstrate cases may have been the result ot the small number of employees exposed or limited experience rather than due to a difference in practices. Because of these factors, plants that do not now appear to have cases of AOL should per form regular periodic medical surveillances since this study cannot predict unequivocally that cases of AOL will not occur in the future. For the same reasons, it is recommended that all plants, whether or not they have had cases, adopt the practices outlined in item 1 above. 104 UNIR0001475 W REFERENCES 1^ Cordier, J. M., Fievez, C., LeFevre, M. J., and Sevrin, A., Acroosteolysis and`Skin Lesions Among Workers Engaged in Cleaning Reactors, Cahiers de Medicine du Travail (Assoc, Prof, Beige des Med. du Travail), January k9 1966. 2. Suciu, I., Drejman, I., and Valeskai, M., Investigation of the Diseases Caused by Vinyl Chloride, Med. interna (Bucharest), 15:967-78* 1963- 3. Chatelain, A. and Motilon, P., A Syndrome of Acroosteolysis of Occupa tional Origin, Heretofore not Identified in France, J. Radiol, et d1Electrologie, MJ: 277-80, 1967. Wilson, R, E., McCormick, W. E., Tatum, C. F., and Creech, J. L., Occu pational Acroosteolysis, JAMA, 201:577-581# 1967* 5. Harris, D. K. and Adams, W. G, F., Acroosteolysis Occurring in Man Engaged in the Polymerization of Vinyl Chloride, Brit. Med. J., jj:712-1^, 1967* 6. Benoit, J. P., Acroosteolysis of Occupational Origin (Doctoral Thesis, University of Lyon), 1968. 7- Albright, L. F., Vinyl Chloride Polymerization by Suspension Processes Yields Polyvinyl Chloride Resins, Chem. Eng., pp. 1^5-152, June 5, 1967. 8. Plesitzer, Bondar, and Smirnova, cited by Danishevski* S. L* and Egorov, M. N., Gig. Truda Prof. Zabolev, No. 9, Vol. 26, 1961. 9* Torkelson, T. R., Oyen, F., and Rove, V. K., The Toxicity of Vinyl Chloride as Determined by Repeated Exposure of Laboratory Animals, Amer. Ind. Hyg. Assn. J., 22:35^-361 (Oct.) 1961. 105 UNIR0001476