Document yKkDVk93obzOEBm6LZLoMQY2

N I en-ms iicv. s-n q u m m im E. I. du Po n t de N em o u r s St C o m pany W ilm ing to n, Delaware EMPLOYEE RELATIONS DEPARTMENT December 22, 1978 P. G. GILBY CD&P B-13265 CHAMBERS WORKS FLUOROSOLFACTANT STUDY Dr. Pell had the study and was reviewing it. His comments are included. - SUMMARY: There does not seem to be any adverse health effectsreported in this study, with the possible exception of an effect on the liver. DISCUSSION The liver function tests should be tabulated to compare the number of persons, not the number of tests, in each group. The matching variables should have included payroll class since there may be large differences between wage and salary employees in dispensary visits, absenteeisms, and the incidence of certain diseases. Attachment I should show the number of persons for each body system. The number of visits can be inflated by one person making several visits for the same condition. Dr. Pell would like to know how significant differences were determined. The percentage of smokers seems high in both groups compared to about 40% in the U.S. The table on page 3 should show the number of employees with abnormal liver function tests. The relation to diabetes is probably not important after the initial exposure because the diagnosis was definitely made in 4 exposed employees vs. 2 definite diabetes in the control group and the diagnosis was suspected in 4 exposed employees vs* 5 in the control group T H E R E 'S A W ORLD O F TH IN G S W E ARE DOING SO M ETH ING A B O U T EID096510 000137 -2 For liver function tests, data should be tabulated to show the number of persons (not the number of tests) in each group with abnormal results. Blood sugars should be tabulated the same way, taking the diabetics into account. To summarize, neither Dr. Pell nor I see any adverse health effects reported in this study. However, we would like to see the liver function tests tabulated to compare the number of persons in each group rather than the number of tests, as well as the other requests noted above. I apologize for not having responded sooner. BWK/ag 'ct BRUCE W KARRH, M.D. /f m nnvM a EID096511 000138