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_Mater 1a I Testen
E 1 du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine
HASKELL LABORATORY REPORT NO. 737-7/ Sample Ready
Other Codes
AR226-2862
Material Submitleci By
B IMARV s k i n IRRITATION ANQ s e n s i t i z a t i o n t e s t s o m g u i n e a pip,*-.
S tS +( S !'/w iT ` of t l t e s ^ " r i T ? r e9 / r i ?p` v ' n9;h nd " 9 h tlv rubl,ln9 1 drp
"o'
9 U . TM pigs. To test for the s e n s I t l S l o T p l s ? a L r i"*,0; the steve<i '"+<* shoeIder skin of 10 J f e
- - oe,r3S S f rsiFi^" three-week period, which consisted of i '*? " T T * L " " s / "traderTMI Injections was given, one
,,
Results:
Concentration in 0 .9$ saline Primary Irritation Test-24 Hours
-48 Hours Challenge Test-24 Hours
-48 Hours Sensitization Response Ratio**
Beactinn-*_Qn Intact Guinea Pin <^jr
Test Ai-p ^ (10 Animals - In. Avg. W t .
Final Avg. Wt.
498 g 729 g)
-Control A rea--s ^ eft oa --r j mChu aIllVe-.I nm oee T Tp sI V ^ .(
(10 New Animals - Average Wt. ~ 733 c)
- 60
6% -- TM L .
m,
I+ 9 neg. 10 neg.
10 neg. 10 neg.
10 neg. 10 neg.
10 neg. 10 neg.
10 neg. 10 neg.
10 nea. 10 neq.
0/10
C o n p M y fesnaSnA. D m mol contain T S C A CBI
2- -
Bsaetlon: +. ++*
= m,ld' mode,'a+e' 5+rn9 * 7
" ^ ' ^ l l e d J n n U n ; or "
I
5 nnmnositlon:
^ g+ challenge over +he response expected from the san
S
________ _____________
M
Report by
.lames D. fftylor Toxicologist
Approved by:
fit /Raymond W. Morrow Chief, Dermal and Ocular Toxicology ec i <
S`s;ir;4?4 $ii