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cs((dodiaamnyyptssah0re0-e-122d000t))moaagt1/5$k25gaanndddo2s114e00(gmmSr.goDg/.u/)kkpiggpnwwrtiehoererreectoo11n00t44ro+l gg(3r5rSoouD(upSp)...DaM.Mn)deeaa2annn6d4ff3oo24oo+9dd0cc7o3o(Snn.(ssSDuu..mm)D,p.pt)rt,ieiorsoepnnsepcvvtaeailclvuuteieevlssye,(ldydaa,asyyacsssoc00mo--p22ma00rp))eaaadrtted505 taao4nn2dd112115=002_mm8g2g/4f/kko(rggSt.wwhDeee.rr)ceeoinn33t66trh33oel+cgro66on00utpr.ol M(M(SeSe.aDDann).)tteaaernnrmmddii2n2n4a6a1l4lbb+ood69d00yyw((weSSie.DDgi)g.h),ht,tmrrmeeissinppnueeucscsttgiigrvvreaealvlvyyii,,ddaauussttcecerooriimmnnepepawawrereeeiddiggththotta34at22t 1155a=ann2d2d38 11f(00o5r.mmDthg.)e/kgicgnowtwnah/taesrso2cl2o9kng93tr3roo+ugl2p2.88 rg(gSroroou.Duugpph..)h. aaiCCnrldlciinon2iai4cct1aa,ll_a_ss.nii6ogg0rnnessx(Siiia.nnD. ss.u)uG,rravvrseiitvsvrpiionneiggcnttddievaasemtmlisysn,aiilannasccnllcuuodddmekedidpdahhnruueenndycchtholiienns3ggi2,o,1nllso_ov_w.we2ee3rrre(bbSnoo.ddDyyo.)wwieineitnigtghhththete,e,chaaoillngdoothppre-oeccliiaa,, Trddoroouessageethddmaahemmnasitsr..c.soeaat,teadnofreetaxliae.ffGecatssttrhoaitnwteesrteinaalt and kidney lesions ibutedtomaternal were noted in the toxicity included: high- Tiinnrccerraeetamasseeedndtrr-ereesslooarrtppettdiioofnnesstaaalnneddffffeeectttaasll tddheeaaattthhw,,eddreeeccarrteetaarissbeeuddteffeedttaatlol bbmooaddtyyerwwneaeiliggthohtxt,,icddieetlylaayiyneecddlussdkkeeeldlee:ttaall 2 Exhibit 1725 7172255..00000011 S1_MNO1660801 3M MN01660801 Met HuthPry Medicine, Health Physics Indi Hoge, Towsley Industrial Hygiene, Toxicology Mesa eparipens 3M Medical Department owConepain 2028.02 3M Center, Building 220-2E-02 POBox 520 PO Box 33220 Sor ss13.3220 St. Paal, MN 55133-3220 S27 io 6127331110 Tooshssseiisffiieccaaettfiifooennc,t,slcloeecffctuppraarlleaatdteep,,rssiuumbabrcciuulttyaannieenootuuhsse eehddiegemhm-aadoaasnneddgccrrroyuyppp.tloorrTchchiiessmmmat((ueunrnnddaeelssccaeennndddeefeddtattleessttiiccllees)).. 'NTNhOOeAsAeEEeLLfSsfeffcootrrs ttohhciiscsussrttruuedddyypwwreiemrreearbbioloytthhin1| mg/kg/day. the high-dose mg(kg/day. group. The maternal and fetal `LAaAnbnooorraraatlolrddieeevsv.eellooppImmnetenintstaalsltttuoodxxyii,cciidttoyys((eteegrraarttooolloouggoyyfp))2sssttuudpdyryeiignnnarraanbbtbbniittesswwwzaeasaslccaoonnndddwuuhccittteeeddraaattbAbAirrtggsuuwssere dPLdoFoasOsbeeSodd.roaotnondrdiaeaysy.ss 7 trough 20 In this study, 7 through 20 odfogseestgartoiuopnswoifth22eiptrheegr n0,an0t.1n,ew1.0z,e2a.l5a,nodrw3.h7it5e of gestation with either 0, 0.1, 1.0, 2.5, or 3.75 mghkgiday rabbits were mg/kg/day PFOS. vMMiattahteerranmnaiallntoioxmxiaiccl eeeffffffeecectttssatiinntcchlluuedde1ed.d:0:mg11))/ddgeeccdrroeesaaess;ee2dd)bbdooeddcyyrewwaeesiieggdhhfttoaaotdthcheoenhhsiiuggmhhpeetssittottnhhrraeteetddhooessee levels levels ahwhitiiggtthhhheeeassthtmittgwiwhneooismddtaootslsweeeossf;f;de33oc))steffarsrteetqqhuueeenn1t.t0ssccmaagnnt/tkffgeeccdeeosssaaett;tt2hh)edhheiicggrhheeeasssttedddoofssoeeo,,daancnoddn44s))uiimnncpcrrteieoaansseeaddt aathbbeoorrttiioonnss at the highest two doses. t hFFeeetthaallittooxxgiicchteewffffeoeedccotstssseiitsnn.cclluNuddoeetdderrreeaddtuuoccgeeeddniffceeettaavllenwwteeisigwghehttreaannoddbsaaennriivnneccdrrieeanassteeheiinsntddueedllayayy.eedd ossification ossification at at the highest two doses. No teratogenic events were observed in the study. BBmaaastseeeddmaoolnn ahthnidiss fssetttuuaddlyyN,, OPPFFLOOSSS awwraeass0.nn1oottmgttee/rrkaagtto/ogdgeeannyiicacnuudnndd1e.er0r mcceoo/nndidieit/tiidooannyss,oorftfesthhpeeectssittuvueddlyyy.aanndd the the maternal and fetal NOELs are 0.1 mg/kg!day and 1.0 mg/kg/day, respectively. "tTTehhruuasts,,ogtthehneeiwwceeeifiggehhctttosoffitnthhaeeteesvvaiiddneednnrccaeeibbniindtidscicawathteeessntthhdaoatst eppdeerrafftluulooerrvooeolocscttwaahnnsiescsahullaffoornnaartoteet ddmooaetesesrnnnooattllccyaauussee setttoeocrxxtaiiictcoo..ngieTTnnhhgieaeerlleteefinnffsseaccccththsaaainnnnggdreeawtoosabbsassnenedrovtrreavfdbeoibiudnnintdsraatwut ppphouuenpnpssrdieionnpsetetahhdteesRaRttiuilkdkeeivecrersPlPshahtawarahrmnmiacicahnecduaeetrupeitecincnaoadlltesnmstttuauldtdeayybrnowwraaaaltlsyosary. sectioning artifact and was not found upon repeat studies at an independent laboratory. 2 11772255..00000022 SW_Mot6s0802 3M MN01660802