Document xzQ0MjnegVRKZrry58ZRzkeV1

To: TO: RRW..TLL... BCBAOOSHHEOONN- --REIENKNEVVRTIRROSOANMFMEEENTNTYTAALELVALLALABDUAT((EIEEOE&ENPPCC)2) 1--8-223115--2-2k04i5--0055 MR3..DTJ.:. DJCAOAVSHEINSSO-N-RO-IKFERFRIICKEESRAFOEFDTRYUGGENENEVERATALLAUBAOCTLOIOIUNSNSHE-L-2=217820-32-S03-5-01-320E5-02 WWAJ..CHDC.:.. MMJNOCOCHCRCNOBOSREROMRMNIGICCKK-- R-1-4IKTCTEOSORXXIRICCDAOORDLLUOOGRGGEYYMGUELSSTAEEATRRBOVVORIILCYCISEEMSSAFF---AI222R227S000---Z32-SE6-2--00025223-5N-06 AWPWC.. FMHH:.. RPNPIEEOEAARHRRBLLLESERSOGONN--C--HI&CCECOMOSMONMLMERIER&TRCDECIIAFRALAELCGTCCUOHHLAREETMYNOIICRACYDAALMLSSIANFDIDFISAIVVTIR.R.SAT--I-O22NZ23Z3---366-55S4-N1-00--10646 DTPD... EFE3".. RSRROCOIEAHAHCECHLHVEER--M-MMAECNEDHDIEICCMOAAOFLLLFIITDDECEEEPPFAAAORRCFTTTMMOGEERENNYNTTEAR-_ADL2ZM22IC0N0O-I-S2U2TEN6RS--0AE02L2TIO-N22-0-4112-1-02 T. J. WF W. F. S37 DKC S. D. SgSSSSCOCUOCOHGRROWEGEENUNNNNESS-ROO--MNNTCACNNO---DOUMI~-SIIENqTNREDODRRCUUIFCISASFIATLAITCLRLREIHIAAYCCLGOLHHIFEEEHHMMNGYIYIECGCEGIAANIEELALENNSDSRHEEA.DDLI--IVVC-,O22. 222UMM000NA-AS--2R2ER2EKLK6E--E-0T0-T0~I2IN2N2GG20---1222E233--0-5525S--0064 AJ. KCC. WEST SUGG WEST -- - COMMERCIAL INDUSTRIAL COt'gqERCIAL CHEMICALS LAB - 236-20-01 HYGIENE ADM. - 220-2E-02 CHEMICALS LAB - 236-2B-01 A. C. GF.FD0L...CFDDC... JS3$3L....2:M0CD00...: FRJR..LEJAE... F. A. Lon bel GGKHHrrraagioigefgefnfhnfiitt---hhGEGee--xnne..TcTouotxxRRieeiissvcc..eoollAooA-nggnayay2ll2yySS0ttee-iirr1ccvv6aaii4llcc-ee0ss3SSeerr--vvii22cc20ee0-ss-226E-=--0022220011--1IW4--2299 KLLHLLiraeaeoozZaakgehihehryryottwene--- EE-E=-xxxCeeCeTcoccoAumuumSmttteeiiirrvvvRcceeeiDiaa---llAd222mC222Ci0h00hne---eim111nis435ictWE6csr---sla033t335iLLoaanbb - 23-18-21 -236-IB-21 - 20-45-01 MOOUcbbbeKeererow-nRMReii-dkkieeIcrr&aClSDDrruuRDgg&eDpMaMeAretdttmmaaeibbnnootillsiitss=rmma2t-0-i-o222n7060----30352S2--200055-4E-01 Ubel - Medical Department - 220-2E-02 0 Flor bir PR 12 198 RJ. BRAS Exhibit 1279 11227799..00000011 33MMAA1100006677117733 ites of Fraehnial tat Commitee peeing, ren 16, 1953 * Fm AT1.O0 LML.iISsTtNORBERG - 1CS RED REGULATORY AFFAIRS - 225-51-06 From: sont WLA. W. HM. H. PEARSON NORBERG PEARLSON - - - COMMERCIAL CHEMICALS DIV. I&CS R&D REGULATORY AFFAIRS COMMERCIAL CHEMICALS DIV. = - 225-63-04 223-5N-06 223-6S-04 Su~ecl Tehore i 8, s 1983 Minutes of Fluorochemical Dale: April 8, 1983 Study Committee Meeting, March 16, ]983 SIM] mTTehhreebeFFrllusuoorraoonccdhheeimmnivicicatalel d SStptuuaddrytyicCCioopmmainmttitstteeeein mmeaettt teoonnndaMMnaacrrecc:hh 16, 16, 1983 1983 with with the the following following members and invited participants in attendance: * RWR..LTL... * RJMRC...DJTJ.... * WAWJ...MCCD...C **++PWAW...C MHHF.... **+.TPD... FEJE... +SWWT...CFJFD... * + A3SJ7... KKDCI.L. * A. C. BBCOAOSHWEOONN- --RIEEKNNEVVRIIRROSONAWMFEEENTNTYTAALELVLLAAALBDUAT((EIEEOE&NGPPCC-)) 2-1-822-131-5-2-2W043--0055 DDCJAAAOVVSHIIENSSSO-N--ROIO-KFFEFFRRIIICCKEEESRAOOFFFEDTRYGUGGEENNEMEEVERRATAALLLAUBAOCTCLOIOUIOUNNSNSSHEE-LL- 221~-7820-22-3203S05----01103225E6--0022 HMJNCCOOCCHROONBRRSEMOMRNIGICCKK-- -R-1IATTKCOOESXXRIIRCCADOODRLLUOORGGGEYYGMUELTSSAAEETRRBVOVOIRILCCYIEESSSMAFF---AI222R722S000---322-SE6---200022523-5-06 PRPNIEEOEAARARRBLLLEESSROOGNN- --C-HICCE&OVCOFOSM~LEIIRRET&RCEDCIIAFRALAELCGTUCCOLHHRAEEYTMMOIIRCCAYAAOLLWSSIAFNFDIDIIASVVIT..RRSAT--I-O22N222332--3-66-5S54-1N--0-014046 SRRROCIOAEHACHCEHLHUEER--M-MMAEENCDDHIIE-CCMAOAOLLFLFIITDDCEEEEPPAAFRORAFTTCHMTOEEGRNNEYTTNEAR--DALM22I20N0C-I-O2S2U6ETN--SR0E0A2L2TIO-N22-0-411-2!6-02 SSSSCOCCOROHMEWENNNUSEOR-- MNACCONO-IM~M-I4ENERODRCFUCIFSIAITALCLREIACCLHHOEFEMMHIIGYCCEGAAINLLEESNSREALDDII-VVC..O2U2MNM0SAA-ER2RL6KK-EE0TT-2IINN2GG20--- 1222E23-3-0-5255S--0044 WSSSEUUOSGGR6TGENS---ONCIINOND-DMUUESSIRTTNCRRDIIIUAAASLLLTRHICHYAYHGLGEIIMEEIHNNCYEEAGLIASAEDDNMNEL..AB--- Z-222220200-3--262E2-E-260-8--2000221 WEST - COI~ERCIAL CHEMICALS LAB - Z36-2B-O! "*WMeemrbbeerrss ooff FFlluuoorroocchheenmiiccaall SSttuuddyy CCoommmiitttteeee TbThlheeoodCCoommmmainidtttteedeeismmceeuttssttoofurtrueervveiieewwFCtthwheoerkcceuurrrrreemnnottnitssottraaittnuusgs oaoffnd '"lffallubuooorrrooaccthhoeernmyiiccraaellsssear((cFFhCC))--iinn-ddbiilrroeeocdc"ttiiooannnssd.. discuss future FC worker monitoring and laboratory research B o8BN1inGl1l1-MNgceCCoooirmmnniiccgHkk.e((TTsoouxxmiimccaoorllioozggeyydSSeetrrhveviiccFeeCss))toxrrieevcviiieetwwyeeddsttatnoodxxiiinccgiittyytosdstatuyuddiiaees:ss ccoomgplleetteedd and on-golng. He sulmnarized the FC toxicity standing today as: - BtBueuiislltddiiinnngggoaaf FssCtt.rroonnggeerr ddaattaa bbaassee ttoo ddeessccrriibbee tthhee rreessuullttss ooff ttooxxiicciittyy ~ThteestirnegsulotfsFCf.ron teratogenicity studies are not cause for concern. ~ TFhleuorroecshuletmsicaflrsomarteeranottogmeuntiacgietnyicstuanddiestoadraetenotnotcacuasercifnoorgecnoincc.ern. Fluorochemicals are not mutagenic and to date not carcinogenic. iIInnn vffiootllrlloooww--ruueppseaddriicsshccuusswssiitfohonnsshighheehessstuuggpggeresisttoeerddittythhogosiseveenaarreetaao:ss for for potential potential animal animal in vFiitrrsot:reseaprlcahtelwietthaghgirgheegsattiopnrioefrfietcytsgiven to: SFeicrosntd:s iplmautneolseutppargegsrseigvaetioenffeecftfescts STehcirodn:d: miamlmeunorseupprpordeuscstiivvee eeffffeeccttss or Third: henopoetic system. Third: male reproductive effects or Third: hemopoetic system. 11227799..00000022 33MMAA1100006677117744 MMMaiirnncuuhtteess16,ooff 1FF9l8lu3uoorroocchheemmiiccaall Study Study Committee Committee Meeting Meeting Page March Page 22 16, 1983 0 SJJiitmnrJJeooshhsnnsseoodnnthe ((RRsiiikkgeenrirfiDDcrruaugngtMMeietntacabrboeolaliisssemmd)) exrrepevevirieiewweeenddceFFCC3Mmmehetatsaabbogolaliiissnmnedsswttuiudtdhiieessmetaahnndodds sthtraetssweidll thgereastiglyniffiaccainlittaintcerefausteudreerxepseeraiernccheac3Mtivhiatsiegsa.ined with methods that will greatly facilitate future research activities. Summarizing his research, Johnson stated radiometric data from snall numbers of rats Summarizing his numbers of rats riensdeicaartceh!, indicate: Johnson stated radiometric data from small - FFaCbC-s-B8o00r77ptiaaobbnssoororpfpttiitoohnne maaoffntteoeerrstooerrraa.ll administration administration is is due due mostly mostly to to - aFaFCdCb-ms-9i9o5n5r,i,psttiFForCCna--t114io43o3f,n,.thaaennddmNNo--neeottehhysy]tlerF.FDOSSEE aarree wweellll absorbed absorbed after after oral oral ~ThaTahredeemaasinnlnioiisoowntnlrssyateoioofxfncr.FFeCCt--e99d55. aanndd FFCC--114433 aanndd metabolites metabolites of of N-ethyl N-ethyl FOSC FOSE - 3CoaCofFhrfhetooerlrlaraesedsldsotiatiywyodorramlaayacimcntnieiitininvsxveeticirttryeatytrttreeiaeaadonnat,dndtmmeedodnfenetcctrrleeffaoaaobssrreeelssessdeevppvellFearaCrsas-aml9mla5addaoaaayrnnyssddFeCelli-nniv1hhve4aea3nrnr.cceerrsasaInddffiieeaooccdaaadaclcitltitiievevoliliniittm,ymyiinnpaarttoiibooennnecid aaappftppeeeararrssadttm oo ineennishhtaarnnacctieeonuurrioinnfaarrlayybeeellleiimdniinnFaaCtt-ii9o5onn ooorffFttChh-ee14a3an.niiooInnn of FC-143. addition, probenecid of FC-143. WB WDDooornn RRaonoadacchh fu((MtNueerddeiiccapa]ll aDDneeeppdaarrtmtmmeedenintct)a) l pparrecestsieevnnitteteiddesaa. sumary summary of of the the clinical clinical work and Clinical fWuortuk:re planned medical activities. Clin-icaESEl pTpWiiiddgoeehrmtmkil:ioyolloodggeyycrmm eoasroetrdataliliittnyycidssettunudcdeyy rroeefssuculoltrtssonrareervvyeeahaleleeaddrt nnoodiasaecdavvseeerrssee(CdHdeDe)aa,tthhss,, = aCasnnllddiignihtthchteaelyl hhHedeeaeaalclltrtehthahyysewwEdovorarklkineuecraritdisseoyynnnncddercrooommnoetef.i.ncuoersonwairtyh h8e0a-r9t0%disveoalsuenta(CryHD), pC paalrirnttiiicccaiipplaatHtiioeoann.l.th Evaluation continues with 80-90% voluntary -- DDeeccaattuurr CCoonntrtrooll SSttuuddyy results results were were presented. presented. Blood fluorine testing using Or. V's biphenyl system. Generally - Btathhrloeeeoadswwoowrfrlhkukeeeorrr'er'issnoepbbplloootoeorddtsutinfFnlilugtuoioerruisisnnienefgorlleDevhvriee. lglsshVe'sraarreeebxippffhaoaeslllulniirnynelgg..esxyisIInstnetm,ssoo.mmteheGeessnwppoeeercrakcieflilfryiicsc' faFallruefuoaeosrrwiinwnieenhcebbireldlooeoonoddcpepslleoevrvlteeeulvlnsseilteihhedaa.svvee fodrr ophpigehdear t dropped at 2 slower exposure a slower rate exist, rate anthde and inworkers' in a few incidences leveled. FFuuttuurree PPllaannnniinngg IInncclluuddeess:: Phase II Health Evaluations changed to every two year basis, from mmPEoohprraieesdeefmfrirIIeeoqqluuoHeegennyattltthoiinnbEtteveerarvvlbaaurllaosstu..igohntsupc-htaong-eddateto uesvienrgyretcwoordysearaccbuasmiusl,atefdrom dd3EuHuprriiiwdnnoeggumlidolllaaoscsttgoyntffrtiioavvecetbyeyeewaaibrrtrssho..ughhLiLteneoonnfuaaoprrr-ddtou-pMM..ddaattSSeecc.hhuuummsaainnng ddiirddecooorrPdiisggiinnaaacllcumFFuCClasSttteuudddyy.. eAA3Mxsspssoewessosususrmlmeede,nnttcfooniirtnnraehhcxiitaggmhhpeewlrrietheexxtpphhooirsmsouuurrgfeehorapareruerpeasdasoastneaoo.lff wwhaayyygssientteoo rarneeddduucceeengiffnuuerrettrhhieernrg mmeooxddpiiofsfuiircceaa,ttiioofnnossr.. example through personal hygiene and engineering RRHoeoaaaclchthhwwiElivllal luccaootnnittioinnnuusee (tteoovemm royonnittiwtooorryetthaheres)hheeaaanlldtthhthooeff 3F3MCH wwloeorvrkekelersrssoftthhrwrooourugkghehrstthheweitcchlliinniiccaall 5-10 ppm in blood Health Evaluations 5-10 ppm in blood ((ee(evvveereryyry ssitiwxxo mmoyonentahtrhsss))).. and the FC levels of workers with eHHexeteeenxxtpprreeassnssteeiddcipccaootnneccdee,rrnnantthdhaathtetthahesekeFFdCC iiinnf wwfouorrrktkeherer'r'ssrbebldloouoocddtioiisns nnionottwoffaraklllelirninggextptooosutthrheee could be accomplished. extent anticipated, and could be accomplished. he asked if further reduction in worker exposure 11227799..00000033 33MMAA1100006677117755 MMMiainrnucuhtteess16,ooff 1FF9ll83uuoorroocchheemmiiccaall SSttuuddyy CCoommmiitttteeee MMeeeettiinngg MPPaaarggceeh 33t6, 1983 GGEENNEERRAALL RREECCOOMMMMEENNDDAATTIIOONNSSEMEMERERGGIINNGG:: - CCEovonantltiuinnauuteeiotntoos-m-motonhniattitoorrfs,wwoorprkhkeyersrsis'c'alhheeaealxltathhminaananddtioFFCCnsbbelloovooeddrylleetvvwoeellssyeabbryys.HHeeaalltthh - MEevaasuluraetiFoCnsi-n-thbalotodis,evperhyyssicixalmoenxtahmsiniantiownosrkeervserywittwhoFCyealersve. ls greater than 5 Measure than 5 ppppFmCm.. in blood every six months in workers with FC levels greater AAddidvfvifisseeerenwwtoorrkhkeaernrssdlitthnhrgroouupggrhhocemmdeeueetrtieinnsggssandttoothccrooonnuttgiinhnuueealrtreeeddrueucdciinnpggersFFCoCnaeelxxppohosysuguirreeenebb.yy - Edlififmeirneantet dhraineddlinFgC mparotceerdiaulress inandplathnrtouegnhviraoltnemreendt, peifrsopnosas] ibhlyeg.iene. -- SEclihmuminaanteshodurliedduFpCdatmeaetepriidaelsmioinlogpylansttudeyn.vironment, if possible. -- SIcnhvuemsatnigastheoueldngiunpedearteingepmiddeimfioicloagtyionsstudiny. higher exposure areas. =- - sIIInnnpevwwceoisorfrtkiikgecearrssoterwwgiaeitntnhhigcinhhifeigglehhureoeinrrrginFFCeCmobcblodloomiofopiddcouantlleideosvvneesllissn inb((leeoh..oggigd..h,, eshr11o55ueplpxpdppmrobseaaunnreddidegganrrreteeiaaaftstie.eerrd)).,, specific organic fluorine compounds in blood should be identified. RESEARCH QUESTION POSED: RESEARCH QUESTION POSED: - Mnat ere the specific organic fluorine compounds in blood of workers? WTTahhdhiiaasspttaiiHrnneavvgooellthnvve'eesssswwgpoaoesrrckkiiicfnnihcggrowwoniiragtthhtaonDDgicoornnaflpHHuhaaoggierecinnn/Hei((euCClRAmcLoL))micpttrooouonwdssaseeveeeiniifpflbaliiosttomdaiiss odfeffeteaeawscsoitirbobklrleeers?ttoo at((hdGBiaCCsp//tMMPPsDDoH))oangessnsyy'isssnttceeemmgasttlooacrwwhgooerrrrokkmeevarrotlougbbmllreooasoopddhiofcss/aaHmmbpeplllloeeoissdu..mwiMIIlittlcriiosnsweaeccdvrreuucctiiopaalllbaesmttaoodradiiwennntiiettcdiituaaorttrieeng the ccthuuirrsrreennsttoonaannddsioonncne--ggooliiannrgggerHHeeaavllottlhhumeEEsvvaalloufuaattbiilooonnosds wttioollaaccccnooemmedmmooddtaaotteebe tthhderesasewenffuudrruttrhhieenrrg tsshtteuuddiieess.. SPECIFIC RECOMENDATIONS: SPECIFIC RECOMMENDATIONS: ~ SOOnFnccoeeprtwwseeefkkonntoowwTeaTtthaheteebsshppuenoecacinfifTiicc oTorrggaaSnniiccaoffllufuooFrrUiinnteeoccooammnpipomoauunnddsmsotiinenBowwtooTrrekkeerorss'F' PbbLlloooodd,, A efforts to relate should continue. human metabolism of FC to anlmal metabolism of FC bAAellettnhhoouusggthhartaaeddd,aattafaurbbtaahsseeeroonntommxeeittcaaibtboyolliissstmnudiaaennsdd mttioogxxniitcciittbeyy oosffugFFgCCestiienndrraafttrssomhhaaissderti- ftfbhieieeccnsaaettiisooctnnoamrtpooeoffdu,nSsdppseefccuiirhfftaiihvcecercncooottmmo.ppxoobiuuecnneiddntssyprsiientnvuidhhiuouemumsaasnnlymbiblglsohototoudddibeeaadnnddsuinugurrgiitennoseetxeidcssiaatmmfpyprlloeemtssesitdiisffe.nti- atIInnhndesaaetddhddeiicttoiipmooopnnos,,usnidbsssippleeichctaiivyffeiicocfnqoqtauufeefssbetteciietooninnnsspgraeassvthieottouosrlppaytrreoottsoeetfiiunndeielbbdiiimnndidiininnnaggtt,,iooxnibbcoomdidytayyybbbuuterredsdteefsnnu.rther aaandddddrreteshsesseeddpobsbyysiebexixplpeiertriyimmeeonfnttssaffiiennctttihhenegmmeetttheaabboorllaiitessmmofllaaebblooirraamttioonrrayyt..ion may be further pIIttrowwgarasasmaaaggnrredeeeddlattbhhoaartat twwoeerynnreeeeeddseattorochccoopnntrtiionnguureeamstthheteoHHetearalyltthhtoEEvevalalulucuaiatdtiaiootnne m mtohoneniteitoforfrieinncggts pp33rMr'oo'sgdsruacFFmtCCs.hahanadvvee on our workers and laboratory research on our workers and potentially programs to potentially on consumers using our try to elucidate the effects on consumers using our products. QM Nest AASe..cWrM.e. taNNrooyrrbbeerrgg FFSlleuucoorrreootccahhreeynmiiccaall SSttuuddyy CCoommimtittteeee CA fp CWW.h.aiH4r.. PPeeaarrlssoonn FCFClolhuumaooiirrrtootccehheeenmiiccaall SSttuuddyy Committee - 11227799..00000044 33MMAA1100006677117766