Document xz4nmnKoj36G7XGRKDYqjQ0Ry

December 8, 1970 QOOQQi Mr. Elmer P. Wheeler Monsanto Company , 800 N. Lindbergh Boulevard St, Louis,. Missouri 63166 ' '' Dear Elmert - . .. ' We have recoived the samples of Aroelors 1221# 5432, 5442, 5460 and MCS 2016 and will proceed with the studies authorised In your letter of 12/2/70. '' Your letter states that the rat oral LD50 of Ardelor 5432 is 61 mg/kg, but the Younger report states 6100 mg/kg, I believe the figure In the letter ie a typographical error. . . We will fill out the table for you as soon as the dates for each study art firm. ' - ' ' Your prices for the acute studies are correct, with one exception. The scute vapor Inhalation studies will cost $200 for the one exposure, which may be adequate if none of the rats die. However, if additional levels of either compound are needed, we charge $150 for each additional level. Under "Teratology" you have a cost of $1, 800 for rabbits. This price is for teratology studies in rats (which we are doing with Aroclors 1242, 1254 and 1260). The price for rabbit teratology studies is $4,500, If you want to use rabbits, the price should be adjusted. We, of course, would give you the benefit of cost saving by the use of common controls in sithc,? species. Zn the subacute rat and dog studies the costs of $6,000 and $10, 000 were given to you for budgetary planning. They actually are high i| common controls arc used. For the deg studies we would use 3 test groups with each of the 4 maturiais and one common centrol greup (13 groups total). - 013803 WATER PCB-SD0000035998 Mr. Elmar P. Wheeler -2- ,Dtcembtr 8 1970 OOOCO'2 With each group ths.aamo ameunt ef taating la doa as tha coat lor each group it the .same ($2, 500). Tha total eaat far tha dag studies will ba $32, 500. or;$3/125-lor each malarial. Far tha rat atudlaa wa would uaa 3 to at-groups with oach e tha 4 ma- tariala and one caounon control group (13 group a tetal). M rat atudlaa wa da histology and blaod taata on tha contra! group and only tha highaat loading level, unlaaa alia eta arp found ! that iovul. (Then rata Irom lowar levels are examined,) Therefers tha costs for tha groupa ara not tha same. Thi ii why tha aatlmata of about $2,100 for tha control group wa* given to you -Since wa plan to feed all four compound* at tha acme timo, I have calculated tha coata accordingly. Tho total fcr the, rat studies'is $20,400; and* divided by' four, amounts to $5, loo par material, *' 'If histology or blood testa ara needed ^xaff'Tad lowar levels, tho coata will ba $20 par rat for histology o $20 par rat for complete hematology and clinical chemistry. [ . ... . ' We ara designing a pratocol for subacute Hah studies, which wa will sand you. aooa. *. N . ' Tb reports of acute fish toxicity studies on Aroelors 1242, 1254 ^nd 1260 are in progress. Wa will sand them as aooa as possible. Bat rag,.rda, _ ' . '_ ' 4 . ` ` * .'*! * ' V ' '' , Sincerely yours, ' ' , '. < ` MLKidb /. M, L. Koplinger, Ffc. D. Manager, Toxicology / 013804 WATER PCB-SD0000035999