Document xz4OqdpVdM2Mep72wVgOoE88b

ATTACHMENT TO LETTER TO C. AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION Perfluorooctanoaiccid MedicalSurveillanacnedEpidemiologic See item I under PFOS: InterimReport#1, Determinationof Serum Half-Livesof SeveralFluorochemicals,June 8,2000. Acute Toxicit I . FinalReport,Acute Oral ToxicityStudy inRats,HazletonLaboratoriesAmerica, Study No. HLA 91201739, 3M ReferenceNo. T-4416 (approximately45% FC-143 solids- C7Hl5COO-Nli4+, 2.2% homologs, 50% water,2.5% inerts)A,pril2, 1990. 2. FinalReport,Primary Dermal lm'tation/CorrosioSntudy in Rabbits(OECD Guidelines)H,azleton LaboratoriesAmerica, Study No. HLA 91201740, 3M Reference No. T-4416, February 14, 1990. 3. FinalReport,Primary Eye lm*tation/CorrosioSntudy inRabbits (OECD Guidelines), HazletonLaboratoriesAmerica, Study No. HLA 91201740, 3M ReferenceNo. T4416, February 28, 1990. Genotoxicit I. FinalReport,MutagenicityTest on T-6358 Measuring Chromosomal Aberrationsin Chinese Hamster Ovary (CHO) Cells,Coming Hazelton Inc.,Study No. 17388-0437, 3M ReferenceNo. T-6358, FC-143, Lot 332, April25, 1996,with protocol. 2. Final Report, Mutagenicity Test on T-6358 in an In Vivo Mouse Micronucieus Assay, Coming Hazleton Inc.,Study No. 17388-0-455,3M Reference No. T-63 58,FC- 143, Lot 332, May 14, 1996,with protocoland protocolamendments. Pharmacokinetics Submitted above under PFOS: An Investigatioonf theEffectsof Fluorocarbonson LiverFattyAcid-Binding Protein,thesissubmittedtothe Graduate School of the Universityof Minnesota, by Deanna J.Nabbefeld,April 1998 Ongoin 1. MechanisticresearchattheUniversityof Minnesota under thedirectionof Kendall Wallace includesPFOA, 3M Reference No. T-6889.1. Documents regardingthis 10 ATTACHMENT TO LETTER TO C. AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION researchhave been previously submitted with the May 4, 2000 submission on PFOS (seeMechanistic 1)(a)-(f)). 11