Document xm56J8w5DjBdqRojQ2wRQmLm
Younger Laboratories
(liock&midi-... PkaAmacal&jiitl... AttalifiU
139 CLIFF CAVE ROAD Saint Louis, Mo, 63ia
PHONSl TIX.OSN 6*9540
SUBJECT -
Texloologloal Inreatlgatlea oft N C 8 312 Moasuto 3aaple Number 146 Moaaaato Prejaot Bobber 1*64-133
IWreaber 12th, 1964
suoeuahed wen trial red aaenacspleallp. Ike 4ata an shows la Mil X.
1} Shla ibeorptiea MUD (Babbits, KLxsd Sex) Ths undiluted eoapoaad aaa applied la laerasalag 4oasa at lasreaeats of a,l fraatloaal lag latsrrala to ths closely clipped, latast atla at nw Zealand white aala aai fsaals rabbits. Ths treated ansa hn mini with plastic strips and ths aalaals placed la sssdsa atoska for periods ap to tesatp-fear hettre, after ahleh tlas they acre asslgaed to ladlrldual cages. Obaenatleas were aade for toxic sjrsptoas aad the risearm ef the --1 that smosashed sen exaalaed aaerescopioally. The data an ahess la Table II.
MOMS 037892
TbU eeafidaede] report ie not to be ueod la eoy fora of advertlaiat without written perroiaeioa
101 Moaaaata Coapaay it. Louia, Mlaaourl
Taaagor Laboratoriaa Cartlflaata of Aaa1/ala paga 2 (11/12/44) - r>d4*13J
EXPMtXMJITAt PROCEDORK - (Contlaaad)
C) Skla Irritation (Habblta)
lha uadllutad ooapaund aaa appllad to tha allppad, lntaat rid* of alblao rabblta and roorad attar tvanty-fvur houra. Tha appllaatloa vaa mind vita plaatla atrlpa to ratard avaparotlaa aad avoid aaataalaatloa.
Okaarvatloaa vara aada avar a parlad of aavaral daya for lrritatloa.
Tha data, aaorad asaording to tha oathad of Dralaa, anadard aad calvary (jauraal of phaia. aad Up* Tharapautlaa, Voluaa 62, Oaaaahar, 1944) aro ahoaa la Tabla XXI
0) qra Irritation (Rabblta)
Oil MUlllltar of uadllatod aaapla aaa plaaad la tha ovajaaatlval aaa of tha right aya af aaah af thraa alblaa rahtlta aad ahaamtloaa aada avar a parlod of aavaral daya tor laflaaaatlaa.
lha ayaa vara rlaaad with vara laatoala aallaa aalutlaa aftar tvaatyfaar houra.
Tha data, aaarad aaaordlac to tha aathad af Oralaa, at al, ara ahoaa la Tabla IV.
g) Vapor lahalatloa (Mala Mate)
Mr 150groa aala rata vara plaaad la a glaaa daalaaatar, 250 aa la dlaaatar, aad axpaaad far ala hoara to a aonaaatratad ataaaphara of vapara pradaaod by paaad ay a atraaa of air throu^i 100 alllllltara of tha aaapoaad aaataiaad la a 250'adllilitar lirlaaayw flaak. Vapara froa tha flask paaaad lata a aar-lltar bottla to raaava dreplata aad thaa lata tha ahaabar.
Air flaa thrauddt tha aaapla aaa flat litara par alaata aa aaaaarad by a aallbratod rataaatar. Thia aaa aafflalaat to vlalaatly agitata tha liquid. Na aapplaaaatary air aaa latrodaaad laaaaaah aa tha abava aupply aaa aapla for tha aalaala oxygaa raqalraaaata.
lha aalaala vara obaaraad far bahavlar aad, alaaa tbara vara ao daatha, all vara hold for taa daya obaarvatloa.
lha data ara ahoaa la Tabla V,
dVMNAKV
BAI.JJL2
A) Oral 10,, (gata, Klxad So*) Tha oral U),t for aala aad faaala rata aaa plaaad at 4500 aHUgraaa par kllagraa vith laaar aad appar llalta of 94<0 ta 7799 adlllgraaa par kllagraa,
Tha aoapawad aaa alaaaad aa praatleally aamtaxla by oral lagaatloa la aala aad faaala rata,
) Skla Ahaarptlaa KLD (Rabbits, Klaad Saa)
Tha Mlalaua Lathal oaaa by Skla Abaorptloa la aala aad faaala rabblta vaa touad to bo graatar thaa 2000 allllgraaa par kllagraa aad laaa thaa Site allllgiaaa par kllagraa. Tha aaapoaad aaa olaaaad aa allghtly toxls by Ala abaorptloa la aala aad faaala rabblta.
MONS 037893
Its IMlJi ttMWrt Trill-r UtowWriw OwtUlwU *f Awlyto* ni 5 <1VW*4) - l44>]
maun - (o--nw*) C) IkU irrltaUw (amtto)
th* w|Nii wa lmH m *Uh *U tMtot tow mtiit -irl'-lTt to lata*t nfetit tola* ah* arms* wt-- ***** m ID Ml *t * i*ulU* i* tmtrAw ton. B) to* urltoitw (tohhtto) to* miwit wi *iii**4 m * *U*bt igr* lltut< to* tnnit *arl--a ***** w 1)>4 w *t * *wihla Uo la t--to" ton* hwr*. o ***** InhaUU-- (wl* a*to) AU trial* wilNt to* tori hwr ll--ri *a **U M to* MMn to* hf ihiWtoU** **ri*4 It wa ***Iatt that to* ****** ** ****U*nD* ii1iiH w4* --HHtim ( to* to*.
The material in this report ie to be used in development of the product nod may he given to responsible sales contacts, but it ie rot to be used by them in advertiring copy. The eource o.` ini i 'nr.'eria1. n roc o he diit'rr | nr t:i h nepenrs in t'oi'mrl ru < ioof ,onn. No ext `n .om to tl.o eif.rtb'`V.. nti rule may be not., v, thr it, mo tipp r "sl o; vV Mtiji-.n'i Departmeat in he. /.cnis.Ciw' tn r-:-' ../1 r:eo rc't.unirrj matters of toxicity or. to bn re ro r. i ho'rip to the Medical DepartBant in St. Louis for reply.
-- Monsanto Chamicai Company
HONS 037894
||i Xf0fcl4| laMratariaa CwtlflHU ( fWi - H|< 4 (U/WM) - t-44-19)
TAILS I w* OML io,, or 'ms nr 70S sati
Saapla M OaAUataA
tort - m
lalftt 1M.
1- mala 2- faaala V Mala 4- Mala 9- faaala
4- mala 7- Halt *- Mala mala 10* mala
11- Mala 11- Mala 19- mala 14- mala 19- Mala
14- Mala 17- mala 11- mala 19- Mala 10- Mala
1*9 21* 230 223 0
no 240 210
23
290 290 219 2*1 249
290 210 2*9 240 290
Saaa MC./U.
9,010 9,010 9,010 9,010 9,010
4,910 (.910 4,910 4, no 4,910
7,940 7,940 7,940 7,9* 7,9*
10,000 10,000 10,000 10,000 10,000
ffctt
SarrlaaO OiaO
SarrlraA SarrlraA SarrlraA
BtaO SarrlraA SarrlraA
MaA Sa,lraA
SaialaaA MaA MaA MaA
SarrlraA
MaA MaA MaA MaA MaA
ouonuoH -
Utl UM I at*i bur Ml
*Mrt m* m rlaaat *900 MUmm ]
u*t* smurm uim>
.
aw swysaaA mo ilUMt m nwtbsUi aamtaala tjr mi lapaallaa la ml* UA fill itti<
larrlral ttaa aimtt (Mr Uja altA wt Aaatka aaaania U taa M**U Wm laaiaAaA Mrm AUrrtua, trim, Ayyma, aM aallayaa* At aatanr a** m Ufto--Um af tha pwtrla aaaaaa M rml *ij| i Wi ampaaaaiA rally.
HONS 037895
ti mmum am/ur St. LnU, Hiaasaii
tN^u UMntwlM Oavtlllaata af AaaVitrta - M|t 5 (U/WM) - T-44-1J3
TAILS II
ns nothin unu oo or 'nos >ii' ST SUN ASlOimON Z> IUBIH
lafli tnll*i WlhM
lalaal sa. - Saa
faigkt (!
mTu-
aiyt Ckaaga 5 oaja Latar
*
1 - Mia
*.T 754
2 - raaala 5.1 1240
J Mia
t.s 2000
4 - raaala 2.7 5140
$ - Mia
2.1 5010
4 - raaala I.S 7540
0.1 - o.l - 0.5 - 0.4 - 0.4 -----
lata
SarrlraS SarrlraS arviraS Mas - 4 Daja Mat 4 para MaS a- 4 gay
D1SCSSSX6R -
As MsIm Latftal Pm *J SSs tPwrpHM la ml* aaS TmbIs iskMta ms (mm Is to sraatar ttu 2000 NIHum nr IUhm ul lw Am n<0 ainigwa pw tlUpM>
Tka aaayaaS m iImhA as iU|iUr Ml kf Mia rtnipUa u aala aal taat lUMM.
arrival ilaa m (w to ala |i)<
MU ayU-- lalaiS pwliil 1m af ayatita, laanaaiig vaahaaaa, aaS iriatra.
Ualaat mhUUm at syosllao m* mM ipiariaUI> tmtptar Um Mart
Saatkav
'
It aatayr Am hn t
wmi la tka laaga aa vail aa llrar liaaalaaatiaa
aaS raaal iiayatlis Monssagtaallr.
HUNS 037096
TCt toaaaata Caapaar it< Lawla, MiMourl
Tuin ukmltrlM OartiilaaAa af wOrrft - p>i ( (U/U/M) - T-44-15J
mu m
SUM IHKTATXOM IM KAllXTt IRQ APPLICATION OP 'MCS 3X2'
laajd* Applia* BaAllaiaA
Aalaal Nuaktr
MWtorlaaX tvaluatioa At Tka to* Of X tour 24 toara 44 toara 72 toara 120 toara
X
0X 1 0
0
2
02 1 X
0
3
0X 0 0
0
ATtMfa
0*0 1.3 0.4 0.3
0.0
DISCUSSION -
T)M airmI aa alaaaaS m t |U|U Ml Inltut Aw appXlaS into* to lAtot iwhkit tola. Ik* apart* torlaaa win m X.) Ml ( a fwlUi la tiwtrfwr town.
IM tola ita|M wi mM la m tov< Siuktol ton aaa tatoLp pa**apLtla rtom to to aalaaXa ato aalWaflato wtwi * to IkM aalaal far aa mt|i mwi if 1-3- to towwa Amlnit. HIUi wiwlrto town to tm flfaa wf tolar to all ntont a Min af aara la An <U/a.
M0NS 037897
i DMHito C*apai7 at. L**l*, Nlsawri
1n>( UkmtwlM Crtlft*at tj ud|di - H| 7 (WU/i4) - y-44-133
TAILS IT
SR IMITATION IN IAMITS ARM APPLICATION ON `NCI 312*
gaapl* (0.1 Miliuitur) AppUK Ba411at*4
Aalaal Baker
Ba*rl*al InlwUM At Th* BN Of 1 Mar 24 l*ara 41 Bar* 7 Bar* 120 Bar*
1
12 4
2
0
2
13 U
i
4
0
3
12 4
2
0
Amt|
13.0 J.o 4.4
2.4
0*0
DIACTIAION -
Th* ipMi n* iIhnA u alight p* lnrltaat. lh* Trmf nil* war* m 13-0 art ( paulkl* 110 la t**at?>far haw*.
Bla*af*rt m *114 i-iKiMy Mlnlai inUiittn. tU|tl r*4a*** *f th* p*lp*br*l ajaaatlra*, alight l**h*tf*t a tra* *f AM*, aal t7 alU **ra**l Mil*-- *lth a* iritis 4*r*l*p*t rlthla *a* hasr. urjUaaa ntM*t la t**at^fr h*sr* aal 4ia*hap|* *--*4. nthta aaraatft** h*ar* **ra*al clarity *aa aaraal aal all aataala r***ir*4 a s**r* *f hi* la flT* taps.
MQNS 037898
Toi Moaaaato Coapaay
at. Louis, Missouri Tonafor Latontori Cartlfiaata of Aaalrala - Piji S (11/12/64) - 1-64-133
TAILS
INHALATICH or 'NCI J12* VAFONS BT JUIS
Arams* Tmparatur* Isolds Chaaksr.................................... Arams* Salatlr* Huaidlty laalSa Chaaksr...........................
Auouat of Saapl* -- T# start ..................... 100.0 *a Nmnt................... 99.) ** rafsrlsaS
7S f. 62 %
Aalsal is. - sas
1 - Hal* 2 - Mala 3 - Hals 4 - Hal*
fat*
Sarrlrsd SurrlTod Sarrlrsd Surrlrad
Ohssrrstlaas Darlas ttpasur*
Ns asssl Us*bars* ... No dyapaaa ... HUd ltthargr Ns ssakass* air dlaaaafsrt ... Aalsala appsar naaffaatad.
discussion -
All oslssls surrlrtd ths air hoar f*aur* aa aall as th* folloolag taa day sksarrsttos frl<4< It sas ssaaludsd that tha rtftn oar* pmstlsaUr aaa-tsxl* uador ooadltloaa of th* task.
As asatlsasd la ths tahla, ths aalsala ayysarod t* bs saaflsstsS by tbs ala kaar aqsnra. Dtssaafsrt sas at a at si am aaS ths oaly ahaass la kaharlar sas ails latharsr aftar ayyrsxlaataly *a* haar. 7k* tsa tay absarratlaa )M saa saaraatfal.
HONS 037899