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PRINTS User:018446 O5nov85 P094 : PR 1/5/ALL (items 1-23) '____________ DIALOG (VERSION 2) R&S 139710 Item PAGE: 1 of 156 23 DIALOG Pile 76: Life Sciences Collection -78-85/Aug (Copr. Cambridge Scientific Abs.) 876034 02000792214 Trends in cancer mortality among workers in the synthetic polymers industry. Presented at: I ri ternational Symposium on Occupational Hazards Related to Plastics and Synthetic Elastomers, Espoo (T inland). 22-27 Now 1982 Nicholson. W.J.: Henneberger. P.K.: lai'r, D. Environ, Sci. Lab.. Mount Sinai Sell, Med., City Univ. New York. New York, NY 10029. USA Pub 1 by: ALAN R. LISS, NEW YORK. NY (USA). 1984. pp. 65-78 198 4 PROG. CLIN. BIOL. RES. 141. In INDUSTRIAL HAZARDS OF PLASTICS AND SYNTHETIC ELASTOMERS.. Jaervlsalo, J.; PFneffli. P. ; Vninio, H. (eds. ) , Languages: English DOC TYPE: Book-chapter article 24 .Toxicology Abstracts A high risk of death from IIver H5A has been documented from past exposures to VC. Similar to other carcinogens, the risk of VC-induced 1iver HSA appears to increase as the second or third power of time from onset of exposure. It is possible to project future mortality using tills power relationship, estimates of VC exposure, arid observed mortality to 1980. Those projections suggest that 200-600 deaths may occur in the United States and 550-2,800 in Western Europe from liver HSA. These projections also suggest that a 1 ppm standard in the VC industry will go far to protecting workers from future malignant disease. Descriptors: mortality; exposure: carcinoma; man vinyl chloride: occupational Section Heading Codes: 24155 833)55 82000695719 Experimental animals. respiratory carcinogenesis In small laboratory Pope Iko. W.E. Environ. Criteria and Assess, Off.. U.S. ERA. 26 West St. C1 a i r , Cincinnati . OH 4 5268. USA ENVIRON. RES. 33(1), pp. 144-188. 1984 L ai iguage s - Engl I sli Summary Languages: Engl Isb DOC TYPE: Journal article-review 24 .Toxicology Abstracts This review addresses. primarily, the effects of inhaled chemicals. with the exception of radioactive compounds, upon induction of respiratory tract cancer in small laboratory animals. With certain chemicals such as vinyl chloride, where lung tumors are not always the major endpoint, a discussion of tumors at other locations Is also included. Studies not included are those In which respiratory tract tumors have been Induced by means other' than inhalation. Inhalation toxicology studies designed to address nononcogonIc endpoints, or studies of such short duration that the development of lung tumor's would be considered very unlikely. Descriptors: reviews: care I nogenes Is: organic compounds: vinyl cli^ldR: respiratory tract: laboratory animals Sect IIng Codes: 24250 OlOO'M 827892 82000682978 Incidence of cancer among vinyl chloride and polyvinyl chloride workers. Heldaas, S.S. Langard. S.L.: Andersen. A. Res. Cent.. Norsk Hydro a s Porsgrunn Fabrikker, 3900 Porscirunn . telemark Sent ra 1 s jukehus . 3. Norway BR' J. IND. MED. 41(1). pp. 25-30. 1984 Languages: English Summary Languages: English DOC TYPE: Journal article-original research 24 .Toxicology Abstracts The results of a follow up study of the incidence of cancer and the mortality in a cohort of 454 male workers producing vinyl chloride and polyvinyl chloride are presented, Tlie s indy population was restricted to employees with more than onn year's work experience in the study plant between 1950 and 1969 and the cohort was followed Lip from 1953 to the ond of 1979. Twenty three new cases or cancer were observed compared with 20.mu I tip1 Ied by.2 expected; one case of liver angiosarcoma was found. The possibility of a causa I relationship between exposure to vinyl chloride and the development of malignant melanomas is discussed. Descriptors: vinyl chloride: polyivinyl chloride): induc tion : carcinoma: occupational exposure: man Section Heading Codes: 24152 817583 82000649852 Toxicity of vinyl chloride and poly(viny) chloride): A criticaI review. Presented at: 2. Annua 1 Symposium on [nvironmental Epidemiology. Pittsburgh. PA (USA). 27-29 Apr 1981 Wagoner' . d . K . 8310 Carrleigh Parkway, Springfield, VA 22152, USA ENVIRON. HFALTH PERSPECT. 52. pp. 61-66, 198 3 Languages1 English Summary Languages: English DDC tYPE- Journal nrtic1e-review 24 .Toxicology Abstracts In 1974, vinyl chloride (VC) was first reported in the open scientific literature to induce angiosarcoma of the liver both In humans and in animals. Additional i esearch lias now demonstrated the care I nogen i c I t y of VC to oilier organs anti at lower concentrations. The target organs for VC now clearly include the liver, brain and the King. and probably tlie IyinphohematopoietIc system. The evidence Tor a carcinogenic risk has been extended to jobs associated with poly(vinyl chloride) exposure. Cases of liver angiosarcoma have been reported among individuals ompIoyed In PVC fabrication facilities and an epidemiological study has demonstrated a significant association between exposure to PVC dust and the risk of lung cancer mortalIty. Cases of angiosarcoma of the I Iver also have hoen reported among Individuals I Ivlrig In near proximity to vinyl ch1 or Ide-poIy(vI riyI chloride) plants. An association between PVC dust and pneumoconiosis also lias been demonstrated. On the basis of findings, prudent control of PVC dust in ttie industrial setting is indicated. Icont. next page) PRINTS User :018-1-16 05nov85 P09-1 PR 1/5/ALL (items 1-23) __________________ DIALOG (VERSION 2)____________________ __________________ ______ R&S 139711 PAGE: 4 Of 157 23 DIALOG File 76: Life Sciences Collection -78-85/Aug (Copr. Cambridge Scientific Abs . 1 Descriptors: reviews: cart: i nogen i c i t y : man Section (leading Codes: vinyl 2-1155 chloride: polyvinyl chloride Opscripioi's r polyvinyl chloride; tonicity; man; reviews Section Heading Codes: 2-115? decnmposi t ion; fumes; 728777 82000-123107 Cause-specific mortality study on VCM workers. Eb i liara , I . Div. Work Environ. and Occup. Dis.. Inst. Sc i . Labour-, Tokyo. Japan J. SCI. LABOU. 58(8). pp. 383-389, 1982 Languages: Japanese Summary Languages- English DOC TYPE: Journal art ic1e- rev Iow 2-1 .Toxicology Abstracts Cause - spec i f i c mortality study on VCM workers employed in M-cornpany was carried out. The colmt was set tip by 226 workmen on I960 and observed tintiI 1979. No cause of death were statistically significant with p<0.05. I iowever, dea th f roni a 1 1 cause, all cancer. gastric cancer, liver and bilialy tract cancer. 'ting cancer, leukemia, hypertension. other heart disease. liver cirrhosis. and accident were higher than expec t ed. Dea t h f row all cause, all cancer. liver and bilialy tract cancer and lung cancer were not significantly higher with p<0.05 level. however, these causes were significantly higher than Japanese male with p<0.10 level. Moreover. the relative death rates of both liver and bilialy tract cancer and lung cancer were increased in accordance with the length of VCM exposure. The results revealed the possibility of carcinogenic effect of VCM on these sites. Descriptors: vinyl chloride: monomer; occupationa1 exposure mor ta1 i t y: reviews; man Section Heading Codes: 2-115-1 692 107 8200033677-1 Polyvinyl Chloride Wire Insulation Decomposition II: ConsideratI on of Long Term Health Effects From Chlorinated Hydrocarbons. Wallace. D.; Nelson, N.; Gates. I. Public Interest Sc I . York. NY 10027. USA Consul. Sorv., 5-19 West 123 St, New J. COMBUST. TOXICOL. 9. pp. 105-108. 1982 Languages: English Summary Languages: English DOC TYPE: Journa1 artic1e-origina1 research 2-1 .Toxicology Abstracts Shortly after health status surveys had been completed on tlie survivors of the Beverly Hills Supper Club Eire and on the f iref i gli ters injured during the New York Telephone Tire, Individual members of each group complained of new disorders and triggered new post-survey "ministudies". Ail women po11ed Showed severe uterine dysfunctions. some resulting in bysterectom1es or other hospitalization. The Telephone firefighter cohort showed atypical pattern of age distribution of cancer cases and cancer types. compared with the Eire Department as a whole. Literature on presence of chlorinated hydrocaid|^iS in PVC pyrolysis and combustion smoke and on the health ^Betsof chlorinated hydrocarbons is reviewed. 010695 659-10 1 8 20002 A 3550 Power Considerations in Epidemiologic Studies of Vinyl Chloride Workers. Beaumont. J.J.: Bros low, N.E. Industrywide Studies Branch F-8. Natl. Inst. Occup. Safety. HI til.. -16 76 Columbia Pkwy . . Cincinnati, OH -1522G. USA AM. J. EPIDEMIOL. 11-1(5), pp. 725-73-1. 1981 Languages: English Summary Languages; English DOC TYPE: Journal artic1e-origina1 research 2-1 .Toxicology Abstracts Nine retrospective mortality studies of workers exposed to vi riyI chloride were reviewed to determine whether differences in their hypothesis testing results might be due to differences in statistical power. Where possible, the power of each study was calculated for cancer of the lung, brain and liver. When power was taken into consideration, t tie results For liver and brain cancer were found to be consistent with an etiologic role for vinyl chloride, for lung cancer, the data were not consistent with an etioiogic role. in that two studies witli very high power yielded negative results. Descriptors: vinyl chloride; occupational exposure: statistical analysis; case survey; man: mortality Section Heading Codes; 2-1152 651637 82000229393 Follow-Up Study on the Carcinogenicity of Vinyl Chloride and Vinylidene Chloride in Rats and Mice: Tumor Incidence and Mortality Subsequent to Exposure. I long, C B. : Wins ton. Woods . .1. S J.M. ; Ihornburg. I p. ; Lee. C.C. : Battel 1 e Seattle Res. C.tr., AnOON.E. -list Street. Seattle, WA 98105, USA J. IUX 1 COL. ENVIRON. HEAL IH. 7(6). pp. 909-92-1. Languages: English Summary Languages: English 1981 DOC !YPE: Journa) article-originnl research 2-1 .Toxicoloqv Abstracts Cai-cinogenic and other toxic effects on rats and mice were examined during a 12-mo period following exposure to vinyl Chloride (VC) or vinyl idene chloride (VDC ) . The results suggest that exposure to vinyl ha tides at dose levels lower than those that elicit a significant increase in cancer i ncideuce during the 1 ifetiine of the animal may, nonetheless. Increase the risk of early death or moribundity from toxic pro- or subcarcI nogen 1c effects. At dose levels higher than 11'OSe consistent witli the physiological defense or repair `capabilities of the Icocnetl,l. neuxtltimpaagtee) tumor Aifntcidence beenines proiiortionaie to length of exposure and may reflect the number of carcinogenic events elicited during the exposure period. Descriptors: vinyl chloride: ethylene dfchI oride: ^urta 1 1 ty =:-..... GjTDlrHjK = KtiuuMAHnii f.rnvri'; nt'' PRINT R&S 139712 L/1MLUU i .... 05 P09*1: PR 1/5/ALL (Items 1-23) I tern page : 8 of 150 23 DIALOG File 76: Life Sciences Collection -78-85/Aug (Copr. Cambridge Scientific Abs. 1 tumor ifieriic i ty : rats; mice Section Heading Codes: 2*1 t52 carcinogenesis; careinogens; me t hodoIogy Section Heading Codes: 2*1222: epidemiology: 2A152X man; tumours: 631626 82000170763 Cancer Mortality of a Group of Canadian Workers Exposed to Vinyl Chloride Monomer. Theriault, G.; Allard. P. Dept. Social & Preventive Med. Sch. Med.. Laval Univ.. Ste-Foy, Oue., Canada. G1K 7P*1 J. OCCUR. MED. 23(10). pp. 671-676. 1981 Languages: English Summary Languages: English DOC TYPE' Journal nrt Icle-original research 2'1 .Toxicology Abstracts The present study was undertaken to find out whether there was an excess of cancer mortality from causes other than angiosarcoma of the 1iver among a group of workers heavily exposed to vinyl chloride monomer (VCM). The mortality Of *151 workers exposed to VCM for more than five years was compared with that of 870 workers from the same company who had not been exposed to VCM. The relative risk for digestive cancer was sign i f icant1y higher than 1 in the exposed group. The standardized mortality ratio for digestive cancer was also higher than that of the general population. Descriptors: vinyl chloride; malt; occupationa1 exposure; tumors; epidemiology: mortality Section Heading Codes: 2*1152 5-1 10*19 *1 103 - XA Epidemiologic investigation of occupational careinogenes 1s using a serially additive expected dose model. Smith. A. H. ; Waxwe iler.R.J. Tyroler.H.A. (Dep. Community Health. Wellington Clin. Sch. Med.. Wellington Hosp., Wellington 2. New Zealand) Ain J. Epidemiol. 112(6). 787-787. I960 Languages: English Summary Languages: English DOC TYPE: Journal artIcle-origlnaI research 2-1 .Toxicology Abstracts A method using the cumulative dose concept has been deveIopeci which Involves calculating the expected yearly exposure for each case from work histories of all noncases close to the case In year of birth and year of hire. The data required for use of the method include information concerning exposure to the chemicals being studied for each job In each calender year of the study. Use of the method is illustrated with a study of angiosarcoma of the liver and vinyl chloride exposure in a polymerization plant. The value of the method lies In the wealth of Information generated concerning the association between chemical exposures and cancer, including exposure level relationships, latency information, and the possibility that 2 chemicals might be acting Independently or Jonlly, 1 lie serially additive expected dose model Is likely to prove particularly useful lit the analysis of data collected by occupational health surveillance Systems. as well as retrospective studies of the type illustrated. Oescr*j^^Hrs: occupational exposure; occupational diseases: 521781 The role of dietary factors in the pathogenesis of primary carcinoma of the liver. Role des facteurs a 1 imentaires dans la geriese du cancer p r - i mitif du foie. Darnis.r. (Hop. Sa int-An to Ine. 75012 Paris, France) Gaz . Med. Fr. 87(22). 2863-2870. 1980 Languages' Trench Summary Languages: French. Engl ish U0C TYPF: Journal article-original research 2-1 .Toxicology Abstracts There is an extraordinary disparity in the geographical distribution of primary carcinoma of the liver. This disease is iOO t imes more common In Senegal . Northern Mai I , Mozambique and Southern Rhodesia than in eastern countries, This is not a racial or genetic phenomenon since black and white populations living in the USA show an equal incidence for this disease. One concept is therefore of fundamental importance: the presence in the human environment, in particular in the diet, of pollutants (mycotoxins. n i trosamines. halogenatod ethylenesl which, with the exception of alcohol, are the chief Ilepatocarcinogens. AfIntoxins grow easily on many foodstuffs in hot and humid countries. A high dose of aflatoxin, in particular aflatoxin R1. results in acute liver atrophy. At very low but repeated doses. carcinoma or the Iiver is produced in many experimental animals and probably in man. Ni trosami ties at high doses, e.g. dimethy1ni trosam i ne. cause necrosis of the 1iver, At low and repeated doses for one year it causes in lire rat a carcinoma of the I iver in 95/, of experimental animals. 1 lip chief risk comes fion meats and r ish treated with nitrites for the purpose of preset-vat i on. Nitrates present in many vegetables and sometimes in drinking water are also under study since nitrosamines mav also he formed in the digestive tract in man from ingested nitrates. Of the halogenated ethylencs, vinyl chloride is known to induce carcinoma of the ] iver in man. It is found in t lie environment- as a pollutant, e.g. as a propellant in aerosol sprays, whilst certain packagings are based upon polyvinylchloride. Descriptors- aflatoxlns: aflatoxin R 1-. mycotoxins: n1trosamme5: vinyl chloride; polyvinyl chloride: nitrates: N-n i trosodimethy 1 amine: food contamination; diets; role; careinogenesis; liver; man; pollutants; pollution; halogenated e t liy I enes Section Heading Codes- 2*1120; 2*1 17 IX; 2*1200/.; 2AIG6X gIPdiriJI O10696 i i -i:f'A null Li ui/ii i r. i PRINTS User :018446 R&S 139713 DIALOG (VERSION i/ALL ( i teins 1 - 23 ) Item PAGE: 12 of 159 23 DIALOG File 76: Life Sciences Collection -78-85/Aug (Copr. Cambridge Scientific Abs. ) 510535 Study of mortality In workers exposed to vinyl chloride. Etude de la mortalite chez des travailleurs exposes au chlorure de viny1e, Pierre.C. ; Tassignon,J.P. (Med. Trav.. USlne de la S.A. Solvay et Cie. 39500 Tavaux. F ranee ) Arch. Mai. Prof. Med. Trav. Secur. Soc. -d 0 ( 12), 1131-1145, 1979 Languages: English Summary Languages' French, English DOC TYPE: Journal article-original research 24 .Toxicology Abstracts Mortality in 1482 workers exposedto vinyl chloride at the Tavaux factory between 1953and the end of 1976 was studied. The results showed an overall mortality less than that of the French population taking Into account an adjustment for sex. age and the period during which the study was carried out. The number of cancer cases observed was quantitatively within normal limits. The relatively young age of the group studied (34 yr) and the small number of deaths does not allow a final conclusion to be made about the effects of vinyI chloride on the health of workers exposed to high quantities of this agen t. Descriptors: vinyl chloride: man; occupational exposure: mortality; studies; occupational diseases Sect ion Pleading Codes: 24 15? 450979 80041250899 5603X3 Health effects of vinyl chloride. T amburro.C.H. (Univ. Louisville. Sch. Med.. Dig. Dis. and Mutr. Sect.. 511 South Floyd St.. Room 53 5, MDR Bui Id. . LouIsville. MY 40201, USA ) Tex. Rep. Biol. Med. 37( - ) , 126-144. 1978 Languages: English Summary Languages: English DOC TYPE- Journal article-original research 24 .Toxicology Abstracts Vinyl chloride Is a basic chemical for plastics manufacturing and has been used as an anesthetic agent. Present clInicnl data In humans now demonstrate evidence of pre-cancer Injury and cancer transformation of various typos of cells in different organs of the body. Manifestations of pro-cancerous injury to organs other than the liver (such as the King, heart, spleen, brain and lymphatic system) may also Lie occurring and require further investigation. Early detection of these pre-cancerous chemical injuries requires a prospective ongoing system of surveillance and the development of diagnostic methods which can identify specific causal agents in the presence of non-spec ITic injury. Such a systematic approach has been developed and Is now in operation. Its Initial achievements appear to bo the foundation for future sticcess In controlling the health effects of Industrial chemicals. Descriptors: early: tumours; detection: symptoms; vinyl ch I or 1 d^sur ve i 1 1 ance : occupational exposure: man Sec t i^^^lead I ng Codes: 24 152 O10097 450978 80041250890 6186-X3 Community risk assessment. Downs.T.D. (Dep. Biometry, Univ. Texas Health Sc I. Cent, at Houston, Sch. Public Health, PO Box 21086. Houston. TX 77025, USA) Tex. Rep. Biol. Med. 37(- ) , 118-122. 1978 Languages; Engl ish DOC TYPE: Journal article-original research 24 .Toxicology Abstracts A simplified account of a statistical method used to assess community risk from environmental carcinogens is given. The method is celled the linear model or sometimes the one-hit model. the linear model Is based on the assumption that the probability, or risk, of developing cancer from exposure to a relatively small amount of a carcinogenic agent is directly proportional to that amount. The linear model Is illustrated with data on vinyl chloride inhalation in rats and subsequent development of liver ang I osarcoma. These results are extrapolated to humans, and the findings thereof discussed. Descriptors: carcinogens; environmental factors: risks; assessment: man Section Heading Codes: 24240 277777 7909 1 200760 I0734-J3: 8 1 7 1 - X 2 Mortality experience of workers In a vinyl chloride monomer production plant. Buffler.P.A. ; wood.S. : Eifler.C. : Suarez.L. ; Kilian.D.J. (Univ, Texas Sch. Public Health. PO Box 20186. Houston, TX 77025. USA) J. Occup. Med. 21(3) 195-203. 1979 Languages: English Summary Languages: English DOC TYPE: Journal artIcle-or iginal research 24 .Toxicology Abstracts: 10 .Oncology Abstracts The evidence associating exposure to vinyl chloride with the risk of tumors at various sites, including lung cancer, is inconsistent. In 1976 a mortality follow-up study of 4Fj4 white males employed ill a vinyl chloride monomer (VCM) production plant sI nee 1948 was conducted. Eight of the 28 deaths observed were due to ma1Ignant neoplasms. Mo angIosarenmas or other liver tumoi-s were observed. A statistically significant excess was noted for malignant neoplasms Of the respiratory system. The effect of smoking, duration of exposure to VCM. level of exposure, and ttie combined effect of duration and level of exposure were analyzed separately. 4 5-yr latency requirement was maintained for ali analyses except for the smoking analysis. I.evets of exposure to VCM prior to 1971 were estimated from monitoring data available for the period 1971-1975 by extrapolating the relative levels for job classifications backwards in time. When the minimum latency period of 5-yr restricted analysis to the mortality experience : after 5 yr fi-oni date of initial exposure to VCM for the 3 14 employees satisfying this criterion, the excess of respiratory cancer was moderate but not significant. Both a longer' duration and a higher level of exposure during tile first 5 yr (coni, next page) . = ti iiijri i.v'iff ' nr PRir\TS _________ User : 018'l6 05novB5 DIALOG (VERSION 2) R&s 139714 P09'i . ............ 23) item PAGE: is of 160 23 DIALOG File 76: Life Sciences Collection -78-85/Aug (Copr, Cambridge Scientific Abs. ) following the date of initial exposure were associated with a statistically significant excess of respiratory cancer. The results suggest that a relationship exists between exposure to VCM and respiratory cancer. Descriptors: vinyl chloride: man; occupational exposure: carcinogenesis: mortality: surveys: respiratory tract tumours re I a tionsh i p Section Heading Codes: 2-1 152; 10057: 10107X 252170 79061261376 4519-X2 Mortality study in VC PVC workers of BASF-Ltd. . Ludwigshafen-Am-Rhein. Mor talitatsstudie bo i VC - - PVC-A rbeitem dor BASF AktIengese11schaft. Ludwigshafen am Rhein. Frentzel Beyme.R. : Schmitz.T. ; Thiess.A.M. ( Arbo f turned, kind Gesundhe i t s schu t z der BAST Ak t lengosel 1scha ft, Ludw1gsha fen/Rhein, GFR) A rbeit smed. Soz1 a 1med. Prevent ivmod. 13(10). 210-228, 1970 Languages: German Summary Languages: English. German DOC TYPE: Journal art icle-orIginaI research 24 .Toxicology Abstracts The results of the prospective mortality study of 1.61B vc-PVC exposed persons are given. Proceedings and analysis were based on the usual international methods, which makes a comparison with other studies possibte. As it was not possible to offer reliable details with regard to the degree of exposure. the mortality of the VC-cohort was investigated by considering VC-exposure periods Of 5, 10. 15 yr and more than 15 yr, with a minimum observation period of 5. 10. 15 yr accordingly. 1 he total VC-cohort was further sub-divided Into groups comprising those who had been exposed before I960 and those who had their first exposure between 1960 and the deadline of the study (31.12.75). The follow -tip of all German employees was 95.5% successful. However (it the case Of the foreign workers, all exposed after 1960. the follow-up was only 60% successful. The study revealed the following results: angIosarcoma deaths could not be registered. Cirrhosis in the liver and myocardial infarctions were less than expected. The expected number of natural causes of death (ICO 0-796) was higher than the number of 6 1 observed cases. 1 he unnatural Causes of death (ICO 800-999) were nearly as frequently observed as expected. The following diseases were more frequently observed than expected: tubercuI os i s of the lung: malignant tumours of the colon and the stomach; hypertrophy of the prostate. They significantly exceeded the expectancy rate although these events only occurred in a few cases. The division of the cohort In groups with exposure beginning before or after i960. showed after a minimum observation period of 5 or 10 hr resp., a higher observed than expected mortality rate for natural deaths if exposure started before I960. The duration of exposure had no recognizable Influence on an increased rate of mortality after long exposure periods. Observations of other studies were not confirmed that King cancer. brain tumours and tumours of the liver were observed more f ^aouently after VC-exposure. or that VC may be a spec I f I^^B- (sk to these tumours. The deviations from other olofifln published nsk-prsdilections could perhaps be due to a dose - response effect, as the VC exposure level within the BASF has always been comparatively low. Descriptors: vinyl chloride: polyvinyl chloride: occupational exposure; mortality: surveys; man Section Heading Codes: 2-1 152 233900 7 904 1 2 A 39 12 3365-J3; 2478-X2 Pulmonary tumors Induced In mice by vinyl chloride monomer. Suzuk i .Y . (Environ. Sc i . Lab.. Mt. Sinai Sell. Med.. T I T tli Ave. and tOOth St.. New York. NY 10029. USA) Environ. Res. 16(1-3), 285-301. 1978 Languages: Engl ish Summary Languages: Engl ish DOC TYPE: Journal Article-original research 10 .Oncology Abstracts; 24 .Toxicology Abstracts Neoplastic effects of vinyl chloride were studied in lungs of 27 mice exposed to vinyl chloride monomer at 2500 and 6000 ppm for 5 and 6 months. Pulmonary tumors were observed in 26 of 27 experimental animals. Ey light microscopy, the tumors were multiple and arranged in either tubu1o-papi II ary or adenoma tons formations. Although occasional mitotic divisions and invaginations into the broncliiolar lumen were observed, no metastases were found. By electron microscopy. short microvilli. tight junctions between 2 adjacent cells, appearance of osmlophilic lamellar bodies, large mitochondria of irregular shape, wel1-developed Golgi complexes, continuous or discontinuous basement membranes. occasional appearance of 'sequestration' and of crystalloids, arid lack of both cilia and mucous secretory granules were observed as characteristic features of the neoplastic colls. Some of the cells were poorly differentiated and were equipped with poor Iy developed organoids, without formation of osmlophilic lamellar bodies. The pulmonary tumors corresponded to ' a Iveo1ogenic tumors or alveologenic cancer'. II is suggested that the neoplastic cells were transformed from type 11 alveolar epithelium via its hyperplastic form. It is cone I tided that mouse lung is an extremely sensitive indicator of the oncogenicity of vinyl ch1 oride. Descriptors: vinyl chloride; induction; lung tumours: mice; careinogenesis: lung Section Heading Codes: 100 12: 24152: 24 154X 229986 79031305509 2462-X2 Perspectives In the Investigation of health chemical Industry. 5e1 i kof f.I.J. (Mt. Sinai Sch. Med.. City Univ. New York, 100th Street. New York. NY 10029. USA) Ecotoxicol. Environ. Safety 1(3), 387-397. Languages: English DOC TYPE: Journal article-review 24 .Toxicology Abstracts (con t. nex t page) hazards In f1fth Ave. 1977 the and )l' I l()N r,f I'.VI' 'f PRINTS User:018AA6 05nov85 P09<1 : PR 1/5/ALL (Items ________________ DIALOG (VERSION 2) _______ ________ R&S 139715 Item PAGE: 18 of 161 23 DIALOG File 75: Life Sciences Collection -78-85/Aug (Copr. Cambridge Scientific Abs.) Rehn ( 1895 ) and contemporaries showed that human cancer' could result from industrial chemical exposure, and laboratory studies Implicated varied and numerous agents. yet until recently human experience had not demonstrated this to be a major problem. The question of whether experiences with vinyl Chloride. bisell Ioromethy1 ether, chromates, etc. demonstrate that the prophesies were correct and is discussed under the following headings: (1) priorities - (a) exposure of large industrial populations: <b) community exposure: (c) suspect agents; (d) long use: (e) planned introduction of agents or widened distribution: (2) methods - (a) toxicological pharmacodynamics; (b) animal carcinogenicity: (c) evaluation of bacterial mu t a gen i c I t y mode Is: ( d ) ep i dein iological : (e) evaluation of teratogenicity observations; (3) mu I t1pIe-factor Interact ions; (A) Industry opportun Ities - (a) epidemiological; (b) environmental surve111ance; (c) medical surveillance; (d) education; (e) long-term, low-level effects: (f) end product use; and (5) special perspectives - (a) current era has unique responsibilities; (b) i ridustry- 1abour cooperation; (c) approaches to control and regu1 ation: and (d) Improvement of scientific communication. Descr iptoi's: chemicals: industries; health; hazards; mail; review Section Heading Codes: 2AI52 10108 A 7 8 12 I201A78 12511-J2; 7A18-XI Vinyl chloride disease. Die V(ny1ch1 oridkrankheit. Veit man. G. ; Lange. C.-E. : Stein. G. (Unlv. -ilautli I in. . Bonn - Venusber g . D-5300 Bonn t, GFR) Hautarzt. 29(A). 177-182, 1978 Languages: German Summary Languages: English. German DOC TYPE: Journal article-original research 2A .Toxicology Abstracts: 10 .Oncology Abstracts Workers engaged In PVC-product I on, who are exposed long-term to the gaseous base vinyl chloride exhibit a complex pattern of effects. Changes of the skin, vascular and bone system, as well as thrombocytopenia, liver fibrosis with portal hypertension. disturbances of porphyrin metabolism and alterations In the CNS were observed. Moreover vinyl chloride is oncogenic and mav cause angiosarcoma of the 1 iver. By direct OCCupatIonaI medicine supervision, improvement of the production conditions and Introduction of new processing techniques health risks at the place of work could be el Irninated to a great extent. Descriptors: vinyl chloride disease: occupational exposure; human; association; vinyl chloride; liver; cancer Section Heading Codes: 2A052; 10057 098705 7811130AI8A 12799-J2; 9058-V11; 6958-XI Benign and malignant associa tions. liver neoplasms; some new Rudolph. R.H. (Mason^l in, , PQ Box 900. Seattle. WA 98 111. USA) POStg^A Med. 63(3). 5G-G2. 65. 1978 etlologlc Languages: English Summary Languages: English DOC TYPE' Journal art icle-mv iow 10 .Oncology Abstracts: 22 .Virology Abstracts: 2rt .Toxicology Abstracts Several agents have recently been implicated in the development or benign and matignant 1iver neoplasms. The development of benign adenomas In women taking oral contraceptives is not common. However, one third of those in whom such adenomas occur- present with Intraabdomlna1 hemorrhage associated with substantial mortalIty. The primary care physician should be particularly alert to this possibility when considering the differential diagnosis of acute abdomen in a women who is taking oral contraceptives . Hepatocellular carcinoma in patients taking androgenic-anabolic steroids likewise is a rare complication. It is. however. frequently fatal. It is important that androgens be used only when the benfit clearly warrants the risk. The initial management of patients with this complication involves simply withdrawal of the androgen preparation. rather than extensive surgery, cheniotherapy. or radiation therapy. Studies linking serologic evidence of viral hepatitis with subsequent development of hepatoma strongly support the hypothesis that hepatitis R virus plays a causative role in primary liver cancer. If an effective immunization program against hepatitis B can tie developed, it mav also be effective in preventing this form of cancer, which is so prevalent in many parts of the world. The association between exposure to vinyl chloride and the development of angiosarcoma of the 1iver lias been recognized recently, and occupational exposure standards have been strengthened. However. this serious occupational exposure hazard should have been predicted on the basis of animal toxicology studies. The fact that it was not emphasizes the need for a stricter policy of screening new materials for potential hazard pi lor to their widespread use in industry. Descriptors: liver; tumour; benign; malignant: aetiology; review; hepatitis virus E Section Heading Codes: 10179: 22115; 2A 100 0273 15 7805 12225 17 278 1-.J2 Clinical studies of cancer etioloqy. L i. F . n. (35 Binney St.. Boston. MA 02215. USA 1 Cancel' A0( 1 . supp 1.1, AA5-AA7, 1977 Languages' English Summary Languages: Fnglish DOC TYPE: Journal artIc1e-or Igina1 research 10 .Oncology Abstracts Clues to causes of cancer in man can be ident if ied through Clinical observation of patients. Alert practitioners have, for example. recently discovered carcinogenic effects of occupational exposure to vinyl chloride and of d iethy 1st i IbestroI therapy during gestation. Clinical case studies have also clarified the role of host susceptibility In development of cancer. In most Instances, validity o<E^L ii nn itial (cont. next page 1 0 I 00!)<l If* 11' PRINTS User:O18AA6 05nov85 P09A : PR 1/5/Al.L (Items 1-23) `_________ '________ DIALOG (VERSION 2)___________________________________________________ R&S 139716 Item PAGE: 21 of 162 23 DIALOG File 76: Life Sciences Collection -78-85/Aug (Copr. Cambridge Scientific Abs.) clinical observations was established by more detailed epidemiologic and laboratory studies. Clinicians can contribute to care i nogenes I s studies by being alert to causes of cancer in their patients. and by referring exceptional observations to clinical epidemiologists and basic scientists for further study. Knowledge of risk factors can be applied to cancer prevention and early detection. Descriptors: cancer: aetiology: role: carcinogenesis: cl ini ca1 ; s tud i es Section Heading Codes: 10056 expected in cancers of the breast and urinary white females. Deficit mortality was observed in liver among both male and female white employees. Descr i ptors: polyvinyl chloride: human; careinogenesis; occupational: exposure; cancer Section Heading Codes: 2-1052: 10057 organs among cirrhosis of mortality: 02362 1 780-11300696 2016-J7 (Current aspects of primary liver cancer. I. Aetiopathogenesis). Aspectos actuales del cancer primltlvo de higado. (I). E t i opa togenia. Herrerias, J.M. : Jlminez. M. ; Garrido. M. ( Dep. Intern. Med, , Un1v. Hosp. Clin., SevI 1 1e. Spain) Rev. Esp. Enferm. Apar. Dig. -19(3), AA9-A56. 1977 Languages: Spanish DOC TYPE: Journal article-review 10 .Oncology Abstracts Aetiopathogenic aspects of primary liver cancer are reviewed with particular reference to geographicaI variations in incidence and age of onset, and to exposure to aflatoxin and other exogenous agents such as cicasine. Senecio alkaloids, polyvinyl chloride. A - d line t hy 1 a zobenzene , dimethv1nirosamine. carbon tetrachloride. drugs such as Ihorotrast and arsenic compounds. The relationship between primary liver cancer and sex. hormone factors, genetic factors and other diseases, especially liver conditions such as cirrhosis and hepatitis, are discussed. Descriptors: liver; cancer; aetiology: pathology: review Section Heading Codes: 10179 022183 7 80A12 1803 3 1736-J2: 1072-X1 Mortality among employees of PVC fabricators. Chinzzo. L. : Nichols. W.T ; Wong. 0. (Dlv. Qlostat. and Epidemiol., Oep. Community Med. and hit . Health. Georgetown Un1v. Sell. Med.. Washington. DC 20007, USA) J. Occup, Med. 19(9). 623-628. 1977 Languages: English Summary Languages: English DOC TYPE: Journal article-original research 2A .Toxicology Abstracts: 10 .Oncology Abstracts A cross-sectional mortality study of A3AI deaths occurring among current and former employees of 17 PVC fabricators during 196A - I 973 is presented. The obJ ectives are: (1) to identify any angiosarcoma deaths among the employees of these fabricators. and (2) to examine the distribution of deaths by cause. No angiosarcoma deaths were found among the study group. Sex - race - cause - spec IfIc Proportlonnte Mortality Ratios (PMR's ) were computed, using the corresponding US mortality as the standard. Among white employees, there appears to be an excess total cancer mortality, particularly that of the digest I^^B system. Observed deaths were found to exceed the m 010700 im imMAiirMi i fw*t rr.