Document xjvm7dpBLxqMOyVJxBQrEV83Q

------------ ................................................-...............O ' t^o> 9 INTERNATIONAL LEAD ZINC RESEARCH OROANIZATION, INC. iM M*e<ON AVlNWl, MflV VO*. * V riS~0** *0*0 <**** 0OI OAtkl *DO|l *Trv|AO NIW *0< : b- Ju* 23, 1967 To: All Hrabcr* of tb* 1**1 tnrlror*nt*l H*altA Comltt** Tromz Jtati C. ftouna* IU: Special Hewttr.* of tb* I*<1 tcrlrooneotal Health Coegeltt** " ' r b*t*i 7tivj-4y, July 6, 1967 TImi 10:00 a.a. Tlac*: IIZTO Coof* react Rocs - 19th floor 29? 1oo Arrow* X*v fork, Brw fork furpo**t To <1k u i Tro>ct Ut-llJ aol tH-109 1) Project LM.ll> To dltcutt, prior to tfa* July 18 e*tlo4 of th* 1**4 Lift 1too Canoltt**, th* proposed Thr** Cltlrt Tyy* Burr*/ ao4 our participation la th* urr*/ with th U.8. Public Health S* rr 1c e aM th* Acwrlcan Petrolrua Xoatltut*. 6** ay ccaacunlcatloo to you &i*4 Juo* 20, 1967. ALto attach*! for your toforsatloo it a top/ of a l*ttr fran Dr. Sort00 of tb* tSTHS to Dr. JUdford of K*tl*rltvf laboratory lovtttof hla to ubalt a prellatnary proposal for pr**ntattoo at th* July 18 Matin*. Tb* Material r*f#rr*4 to by Dr. Sort00 ha* alr*dy t**n *ol to you. 2) Project I*.109 To dl*:v whether thU work, which It being conducted at tha^nlrer* lty of California, Hleeralde, tbouli b* el*f>3*d for a/v,tbr y**r. Zt It **p*cted that tb* propteal will b* received frua lb* contractor In tit* for tb* netting. Plea** return lb* attach** th**t Indicating whether or hot you will b tbl to attend lb* a*#t ing. JCAitw attach. t r t / 'fPM m - fJHSPJi ^1 ^fagg**??*** *'**** "".'T-1 c.'" <\pm wv -jj' ,:y *va ytgy*. .! '...nut / . - - *v  V Edvard P. Radford, M.D. Profsssor and Director College of Had1cine Kettering Laboratory Eden Avenue Cincinnati, Ohio b}219 Deer Dr. Redford: Wring the leet tvo yeora there hee been en Increase In Interest In lead toxicity end In the significance of atxeospherlc leed levels. This resulted In a tysposlua on the subject held by the ' Public Health Service, foLlowd by considerable testimony on this subject presented at the hearings of a Senate conlttee chaired by Senator Hustle. Because cf this Interest the Public Health Service has forced a lead liaison cc*lttee to consider the needs for further research, and to keep the organisations concerned Inforeed as to current Investigations In order to alnlAlse dupllcatlco and gaps. The ceasbera of the ccws It tee are drawn froo several Interested IddJ agencies, and frua a nunher of Industrial associations which are concerned with the production and use of lead. ,' la the process of reviewing research Deeds It was felt sore should be known regarding the relationship between aablent air lead levels and the body burden of lead In son. Existing data, particularly thcee frtsi the three city study which was done s few years ago, iodl cate a rtugh relationship of Increasing blood and urine lead levels la grc*upe who have exposures to increaslcg sir lead levels. The relationship Is not precise or reliable, but requires further loves* tigs'.loo. This would suggest that as air lead Increases In the ecraruil'.y the lesd burden of the exp>d population increases. If this Is lroe it ehcriId be documented, and ijuantltative relationships should be deterained, tf pc-sstile. A sub-ceattlee was for*l to cons'. tr the Beans of dterlnlcg the answers to thsse j'lestU-r.s by **ar> of prospective surveillance, f.sierat possible a* ban Is as of -I,leg this wore explored, Hst were ur.satSsfa tor/. Eventually It was iteteralned that a ol!flel version of the three city study W,1J le the Sul satisfactory Bethod of dealtrg with this problem. The sub'-.tslltee feels strorgly that ths whole study sh'u.'.d to csrrted t.#l by one Institution Mitch 1* exper* teheed In lead research in both eeroaelrl? and blaaedtcal aspects. t 'i-i-,'7' " i". '.-C `*'5* N 493.01 \ -2- I have been asked by the subcowslttee to Inquire whether or Dot the Kettering Laboratory would be vllllng to undertake this work. If so, could you prspere a preliminary propoaal for presentation and coos Id rat loo at the Mxt meeting of the Lead Liaison Ccanlttee. It la hoped that this meeting can b* bald la Washington on 16 July, funds for this study hart bean budgeted by several of the organisations on the CanaIttee. I sa enclosing the minutes of the two meetings of the subcooalttee which decided upon this study. These contain a nunbar of decisions on design. Tour staff's suggestions on the protocol would also he of Interval. The Information referred to In Item 9 of the flret minutes Is not yet completed and will be furnished later. Sincerely yours. Enclosures cc: Subccaalilee Meebers Dr. V. ftlggsn HJM!: mb Robert J. M. Horton Acting Chief Health Affects Research frogram y - 'H'.fcVisO , i N 493.02 I