Document xdY2kY5Kkpr2R7Ren7vjDk0b1

ESSO RESEARCH 'AND i f i s C COMPANY MEDICAL RESEARCH DIVISION JAN24 1967 y. O. BOX 45, LINDEN, N. J. 07036 Dr. G. H. Baylor Texaco, Inc. . 135 E. 42nd Street New York, N. Y. 10017 CHB ERS GCA JRE AED RGW January 23, 1967 Dear Curt: . ' ' ' ' }C\ ' . ^ One of the things I .promised to do at the last meeting of the Central Committee on Medicine and Health which has slipped my mind until the present was to write you concerning the potential studies that the Public Health Service would like to see done on lead workers in industry. You will'remember that as API1s representa tive on the Lead Liaison Committee with the Public Health Service I was provided with certain studies which they flt might be worthwhile undertaking in an attempt to answer the question of whether or not lead is having an effect on the health of the general population. They passed out to us the five sheets which I have attached to this letter. Of particular interest were the studies suggested by No. 1 under Occupational Group Studies on Lead. In this regard I agreed to contact the medical directors of the three major automotive manufacturers and see if-they would be will ing to do studies of this nature on their lead workers. In addition, I agreed.to contact, through the Central Committee on Medicine and Health, the medical directors of the oil industry to see if they might be willing to undertake comparable studies in lead workers in the oil industry. Actually, the.number one study under Occupa tional Group Studies on Lead parallels quite closely the epidemiology lead studies number one project. :; * 1. The question which I posed to the Central Committee on Medicine and Health at its meeting was whether the medical directors of the petroleum companies would be willing to participate in such a study. In my view, the data .are usually probably already available in the medical records maintained by the various petroleum com panies, and it would be simply a matter of getting the data out and putting it down on paper. Thus, blood and/or urinary lead levels could be correlated with any critical findings that might be available, including hemoglobins, red counts, Or other blood effects specifically. It is very likely that nobody has done red cell fragility studies, and that this information thetefore probably would not be avail able, but it could be that one or another of the petroleum companies would be willing to undertake red cell fragility studies in their lead workers and attempt to corre late this with blood and/or urinary lead levels and environmental lead levels, if such are available. . It just seemed to me that a study of this nature could be done by the various petroleum companies involved in the Central Committee on Medicine and Health and perhaps collect valuable information which would add to the already available information indicating that lead exposures less than a certain figure do not.consti tute a hazard to anyone. I would sincerely hope that the petroleum companies through their medical directors would cooperate in such a collection of data for the Public Health Service, since it would be invaluable to the Environmental Health Committee in its discussions with the federal authorities on the hazards of lead, in our environment. '. As indicated, I have already met with Bud Irvin, Marion Jocz, and Dan Steiner to see if they would be willing to participate in a study of their workers. My letter of December 7, 1966, outlines more or less the thinking I have on what . this study might consist of, and I.am including it since I think it might be of value to 7/ou in attempting to assess whether the petroleum industries will coojperate in this, study, . . . : A. V y ' .y . After you have had an opportunity to review the attached information! :- and should you still have any further questions concerning the nature of the study . y to be undertaken, perhaps we could get together sometime in New York and discuss this more fully. I would hope that a decision on this might be reached at the - .y May meeting of th Central Committee on Medicine and Health in order.that this . Y; information might be conveyed to the Public Health Service. Might i also add y parenthetically that lack of cooperation by the petroleum companies in such studies might well be seriously misinterpreted by the Public Health Service. ! '` i; Sincerely yours, REE:bsn Attachments i K 0 0 l S ] 6 `i) / y m m &m wm ,: - u- .-', . 1* Il e a j o r G & & X 9 'c?f ,iatfias ifes taitii :i;;: effrts e eternici 33* t-tes* 'aspdfchft $& tal' B s t^ a ^ rSa - / IsScstry ricorda# Isagsr a foySOag Ssvi Gf Icd ero niiiaelr' is s i!schedi stai luoed caci vsrls. tsej^ottr^aoefcs ero t ^ a e t ^ s ric d ic ! ictosvals# it Biyls'l lX) pccaiti! te 9 faei retrospective di ^ tm . o s ,', =. b 3bske s ?^ io otrtlaLA ce&rsri ,e:sm&Qd te l$&i.la"t2a ' ' wsS-asf parir&esosi* ita sag^lOBeatsii 7 ethee escgs&e xwsulilr^ a giveis blccd- lead avola eftcr ci f*ivsa soriod cf tSsaa t3it seQutrsd 7 c s & & s y pcllsy io arcqu&a traaaSor io & lessiir cxpcstre* Tj% r-ia'sese vsUs blcsd leaJ So ola cS *03 or .07 oilllsrzaa p k f ICO c r : ^ cS Lisca r.?c>- raactituio ca> osh&rt v.?:lt otcr LSocdl r.Vj'sj r> il'v rcr^i.U'ir.^ ccbcrts# I^esot srl&sf cedici te a l l e v i ibsss^'.oaS ttrir Ciliare vsi^iias . 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K i : : i . t .V.:; .-^. * r ^- ; ;: " :.:, ..-- - ^ 'y x . ..^.. , . . '' ' ^v- v -'-; "vi-':- ' .;;' : '^ ". ''V ' :' ^ '-:' ;;s^ :.^ Occupational Group -Studios oa--toad X -7- *.v - .. I.' Scleral fragments of current information, mainly related ^ to the blood pfenning system,1 indicate* that'blood'and '. urlno lead levels presently believed safe^ may sot in foot fce so* Hose of the indorsation pointing to this . '. possibility $3.satisfactory for use in alterins'control ' progress It does raise enough doubts so that careful reevaluatioa of current concepts is in order* This can . probably be done'by the use of existing industrial data from the supervision of lead-exposed employees t e a '7 I Ic^lly have fcnl urine lojsdti level* blj&^t . ,,; 'fragility, and urinary coproporphyria done a preliminary survey could easily fee done by grouping subjects accord- lag to bleed lead levels and again according to urine . .leiid l o y o l s : '.iff for hemoglobin, bleed count, fragility and coproporphyrias f||ljtpi; 1 - level it should bo apparent In such a design* Evidence ., .: for or against other types of injury from lead could' also be sought in the sane pattern* - - 2. There are also unsatisfactory fragments of information indicating that load exposures above and/or hole# those producing lead poisoning nay also produce chronic illness, particularly hidaey disease. This problem also merits core careful study to 'decide whether cr not such damage is in fact occurring, Tuo industrial groups lend them- solves to such a purpose* Groups mentioned in the first section can be classified Into cohorts by length of es- pesuro or by blood loveIs (cr by both), and followed . .. for differences in life"expectancy and health status ' . as compared to non-espessd groups. Cases of industrial lead poisoning could be subject*to follcv-rp study ia the nnaaer used previously for children by Henderson ,.,: ud by Topper?(sic)-# Comparison *groups should probably . be employed* .... .. ....... ... . ; .. ,, - . ..7 -; '. " 7 .'"'7.--.'' .ZJ'r^ ,v --7"'.^'''7c-. ^ ... 7 X / 7 7 X X X7V'j X7 7 7 77777 -77''7-7.; :7- :7.-77 -lvi-7 77 . '"7; 777: ? .:.>77;a . 7 -.;.'5' ' : i . \ -~ 77'77::U7777'f s. i-.-, K 0018474 ; . ; : . .;