Document xdQ9d7E9VNV4ED0oRbeQZwYmE

Pathology and Toxicology RNcer Liboratoriea, Inc. Building 270-3S -05. 3M C enter S t Paul, M innesota 5 5 1 44 -1 0 0 0 AR226-OV38 TWO YEAR ORAL (DIET) TOXICITY / CARCINOGENICITY STUDY OF FLUOROCHEMICAL FC-143 IN RATS (RIKER Ex p e r i m e n t No . 0281CR0012) Volume 2 o f 4 Co n d u c t e d Du r i n g Ap r i l , 1 9 8 1 - Ma y , 1 9 8 3 RIKER LABORATORIES, I n c . / 3M Company U.S.A.St . Pa u l , Mi n n e s o t a 5 5 1 4 4 - 1 0 0 0 000679 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4643 Sex: Feaale Group: ( 5) FC-143 300 ppc Fate: (Neek= 78) Sacrificed in extreais Microscopic Observations (continued): Lung Lyaph Node (aesenteric) Farathyroid Pituitary Spleen Uterus -Vascular aineralization, aild Heacrrhage, diffuse, aarked -Not exaained, aissing -Not exaained, not in plane of section -Adenoaa -Heaossderosis, aoderate -Cystic glands, aild The Following tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Marrow, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Ovary, Maaaary Gland, Trachea, Adrenal, Thyroid, Pancreas, Salivary Gland, Eye. Aniaal Nuaber: 1R-4644 Sex: Feaale Group: ! 5) FC-143 300 ppa Fate: (Week: 103! Tenir,al Sacrifice Macroscopic Observations: Maaaary Gland Microscopic Observations: Adrenal Kidney Liver Lung Maaaary Gland Pancreas Urinary Bladder -Lobular aass, 3 ca dia., right axilla. -Sinusoidal ectasia, cortex, aild -Pelvic aineralization, ainiaal -Hepatocyte vacuolation, aultifocal, aild Hepatocyte alteration, vacuolated, focal, aild Hepatocyte alteration, basophilic, focal, ainiaal Hyperplastic nodule -Vascular aineralization, aild Alveolar aacrophages, aultifocal, aild -Fibroadenoaa -Not exaained, aissing -Not exaained, aissing The following tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Harrow, Spleen, Heart, Stoaach, Saall Intestine, Large Intestine, Aorta, Uterus, Ovary, Pituitary, Trachea, Thyroid, Parathyroid, Esophagus, Lyaph Node (aesenteric), Salivary Gland, Eye. Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: To Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4645 Sex: Feaale Sroup: ( 5) FC-143 300 ppa Fate: Uieek= 105) Terainal Sacrifice Macroscopic Observations: Maiaa-y Sland Microscopic Observations: Adrenal Aorta Kidnev Liver Lung Lyaph Node (eesenteric! Masaary Sland Parathyroid Fituitary -Large aass, 10 x 4 ca, right axilla; lobular aass, 5.5 x 5 x 4 ca, le ft inguinal. -Sinusoidal ectasia, cortex, Barked -Not exaained, aissing -Pelvic aineralication, aild -Portal acnonuclear cell in filtra te , aild Portal bile duct proliferation, aild -Alveolar aacrophages, aultifocal, aild Heaorrhage, local areas, aild -Heaorrhage, Barked -Fibroadenoaa -Not exaained, not in plane of section -Adenoaa The fo llo n ing tissues nere found to be within noreal lia its : Brain, Spiral Cord, Bone Marrow, Spleen, Heart, Stomach, Siall Intestine, Large Intestine, Urinary Bladder, Uterus, Ovary, Trachea,i Thyroi d, Esophagus, Pancreas, Salivary 61and, Eye. Aniaal Nuaber: 1R-4546 Sex: Feaale Sroup: ! 5) FC-143 300 ppa Fate: iNeek= 105! Terainal Sacrifice Macroscopic Observations: Maaeary Sland Microscopic Observations: Adrenal Heart Kidney Li ver Lung Maasary Eland Ovary Pancreas Parathyroid -Saall nodular aass, 1 ca dia., le ft axilla; nodular aass, 4 x 2.5 ca, right axilla. -Sinusoidal ectasia, cortex, aoderate -Myocardial fibrosis, focal, ainiaal Myocarditis, chronic nonsuppurative, focal, ainiaal -Chronic progressive nephropathy, ainiaal Pelvic aineralization, earked -Portal aononuclear cell in filtra te , aild -Heaorrhage, local areas, aoderate -Adenocarcinoaa Fibroadenoaa -Tubular hyperplasia, aoderate -Acinar atrophy, ainiaal -Not exaained, not in plane of section Species: Rat Project Nuaber: 02B1CR0012 293Suaaarized STAR Page! 129 C006S1 Suiaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anieal Nuiber: 1R-4G46 Sex: Feiale Group: ( 5) FC-143 300 ppi Fate: (Week* 105) Terainal Sacrifice Microscopic Observations (continued): Pituitary Salivary Bland Uterus -Adenoia -Not exaained, lissing -Cystic glands, lild The following tissues sere found to be within norial l i i i t s : Brain, Spinal Cord, Bone Marrow, Spleen, Stoeach, Seall Intestine, Large Intestine, Urinary Bladder, Aorta, Trachea, Thyroid, Esophagus, Lytph Node (lesenteric), Eye. Ar.isal Nuiber: 1R-4647 Sex: Feeale Group*. ( 5) FC-143 300 ppi Fate*. (Week* 105) Teriinal Sacrifice Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Esophagus Kidney Liver Lung Ovary Parathyroid Pituitary Thyroid Trachea Urinary Bladder -Mass, 0.5 ci dia. -Sinusoidal ectasia, cortex, larked -Not exaained, lissing -Chronic progressive nephropathy, ainiial Pelvic aineralization, ain iia l -Hepatocyte vacuolation, aultifocal, lild -Vascular aineralization, aoderate -Cyst, unilateral -Not exaained, lissing -Adenoia -Not exaained, aissing -Not exaained, aissing -Not exaained, aissing The following tissues were found to be within noria! l i i i t s : Brain, Spinal Cord, Bone Marrow, Spleen, Heart , Stonach, Siali Intestine, Large Intestine, Aorta, Uterus, Maiiary Gland, Lyiph Node (lesenteric), Pancreas, Salivary Gland, Eye. Anieal Nuiber: 1R-4648 Sex: Feiale Group: ( 5) FC-143 300 ppa Fate: (Week* 88) Found Dead Macroscopic Observations: Haiiary 61and Microscopic Observations: Eye Kidney Large Intestine -Large fira subcutaneous aass, 12 x 9 x 5 ca, on le ft side. -Net exaained, aissing -Pelvic aineralization, aild -Not exaained, aissing Species: Rat Project Nuiber: 0281CROOI2 Suiaarized STAR Page: 130 Z 9 4 C0632 Suaaarized Single Tabulated Aniial Report (continued) Individual Hacroscopic and Hicroscopic Observations Riker Laboratories, Inc. 3H FC-143: Tko Tear Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4640 Sex: Feaale Group: ( 5) FC-143 300 ppa Fate: (Neel- 88) Found Dead Hicroscopic Observations (continued): Lung Lyaph Node (aesenteric) Haaaary 61and Parathyroid Skin Saal1 Intestine -Vascular aineralization, aild Alveolar aacrophages, aultifocal, aild Perivascular aononudear in filtra te , aild -Not exaained, aissing -Not exaained, aissing -Not exaained, not in plane of section -Fibrosa -Not exaained, aissing The folloning tissues Here found to be aithin noraal lia its : Brain, Spinal Cord, Bone Harron, Spleen, Liver, Heart, Stoaach, Urinary Bladder, Aorta, Uterus, Ovary, Pituitary, Trachea, Adrenal, Thyroid, Esophagus, Pancreas, Salivary Gland. Aniial Nuaber: 1R-4649 Sex: Feaale Group: ( 5) FC-143 300 ppa Fate: (Meek= 105) Terainal Sacrifice Hacroscopic Observations: Pituitary Naeaary Gland Hicroscopic Observations: Adrenal Kidney Liver Lung Haaaary Bland Ovary Parathyroid Fituitary Salivary Gland -Raised aass, 0.8 ca dia. -Saall aass, 1 ca dia., possibly inflaaaed ailk cyst, perineal area. -Cortical atrophy, bilateral, acderate -Chronic progressive nephropathy, aild -Portal aononudear cell in filtra te , aild Portal bile duct proliferation, aild -Perivascular aononudear in filtra te , ainiaal -Galactocele Fibroadenoaa -Tubular hyperplasia, bilateral, aoderate -Not exaained, not in plane of section -Adenoaa -Not exaained, aissing The following tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Harroa, Spleen, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Trachea, Thyroid, Esophagus, Lyaph Node (aesenteric), Pancreas, Eye. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 131 295 G006S3 Suiianzed Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Tno Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nuaber: 1R-465 Sex: Feiale Broup! ( 5) FC-143 300 ppe Fate: IHeek= 104) Sacrificed in extreeis Macroscopic Observations: Pituitary Skin Haiiary 61and Microscopic Observations: Adrenal Kidney Li ver Lung Maaeary Bland Ovary Parathyroid Pituitary Skin -- -Heaorrhagic aass, 0.1 ci dia. -Raised circular inflaiied lesion on le ft rear footpad. -Round lass, 1 ci dia., in inguinal area. -Sinusoidal ectasia, cortex, lild Medullary cell hyperplasia, unilateral, oderate Pheochroiccytoia, alignant, unilateral In filtra tio n of neoplastic tissue into surrounding connective tissue. -Pelvic aineralication, aild -Portal ononudear cell in filtra te , iiId Portal bile duct proliferation, ciId Hepatocyte vacuolation, aultifocal, aild -Vascular aineralization, aild Perivascular aononuclear in filtra te , ainiaal -Salactocele -Tubular hyperplasia, bilateral, aoderate -Not exaained, not in plane of section -Adenoaa -Pododeraatitis, ulcerative, hindleg, unilateral, larked The foilouing tissues were found to be within ncrtal lia its : ' Brain, Spinal Cord, Bone Marrou, Spleen, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Trachea, Thyroid, Esophagus, Lyaph Node (aesenteric), Pancreas, Salivary Bland, Eye. Aniial Nutber: 1R-4B5! Sex: Feaale Group: ( 5) FC-143 300 ppa Fate: IHeek= 96) Sacrificed in extreiis Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Esophagus Eye Large Intestine Liver -Raised aass, 1.1 c i dia. -Sinusoidal ectasia, cortex, aild -Not exaained, aissing -Not exaained, aissir.g -Not exaained, aissing -Hepatocyte alteration, vacuolated, focal, aild Species: Rat Project Hueber: 0281CR0012 OQ/1 Smiarized STAR Page: 132 7 0 GO0634 Suaearized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anieai Nutber: 1R-4651 Sex: Feaale Group: 1 5) FC-143 300 ppa Fate: (Week= %) Sacrificed in extreiis Microscopic Observations (continued): Ovary Parathyroid Fituitary Salivary Bland Thyroid Urinary Bladder - -Mb diagnosis, inadequate section -Not exaained, aissing -Adenc-aa -Not exaained, aissing -Not exaained, aissing -Not exaained, aissing The following tissues were found to be within norea! l i i i t s : Brain, Spinal Cord, Gone Marrow, Spleen, Kidney , Heart, Lung, Stoaach, Snail Intestine, Aorta, Uterus, Maieary Gland, Lyaph Node (aesenteric), Pancreas, Trachea. Anna! Nuaber: 1R-4653 Sex: Feaale Group: ( 5) FC-143 300 ppa Fate: !Week= 87) Sacrificed in extreeis Macroscopic Observations: Pituitary Haaaary 61and Liver Microscopic Observations: Adrenal Esophagus Kidney Liver Lung Mastery Gland Pancreas Pituitary Spleen -Heaorrhagic aass, 1 ce dia. -Milk cyst in right inguinal area. -Pale -Sinusoidal ectasia, cortex, ai Id -Not exaained, aissing -Chronic progressive nephropathy, air.ii.al -Hepatocyte vacuolaticn, diffuse, aarked Mononuclear cell in filtra tio n , aultifocal, parenchyaal, aild -Pneuacnia, in te rs titia l, chronic, aultifocal, ainieal -Within noraal lia its Milk cyst not included with section exaained. -Acinar atrophy, aild -Adenoaa -Heaosiderosis, aild The following tissues were found to be within noraal. 1ia its: Brain, Spinal Cord, Bone Marrow, Heart, Stoaach,, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Trachea, Thyroid, Parathyroid, Lyaph Node (aesenteric), Salivary 61and, Eye. Species: Rat Project Nuaber: 0281CR0012 Sueiarized STAR Page: 133 C . 7 ! C006S5 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3N FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nutber: 1R-4654 Sex: Fetale Group: ( 5) FC-143 300 ppa Fate: tWeek= 57) Found Dead Macroscopic Observations: Mataary Gland Microscopic Observations: Aorena! Esophagus Heart Liver Lung Mattary Gland Pancreas -- -Subcutaneous aass, 6 x 5 x 2 ca, in le ft a xilla. Hass was aultilobular and reddish pink. -Sinusoidal ectasia, cortex, aoderate -Not exaained, tissing -Myocarditis, chronic nonsuppurative, focal, ainiaal -Portal bile duct proliferation, tild -Pneunonia, in te rs titia l, chronic, focal, aild -Fibroadenoaa -Pancreatitis, chronic, diffuse, aoderate The following tissues were found to be within nortal l i t i ts: Brain, Spinal Cord, Bone Marrow, Spleen , Kidney, Stoaach, Stall Intestine, Large Intestine, urinary Bladder, Aorta, Uterus, Ovary, 1"itu ita ry, Trachea, Thyroid, Parathyroid, Lytph Node resenteric), Salivary Gland, Eye. Aniaal Nutber: 1R-1657 Sex: Fetale 6roup: ( 5) FC-143 300 ppt Fate.' (Neek= 105) Terainal Sacrifice Macroscopic Observations: Mattary Gland Microscopic Observations: Adrenal Eye Kidney Liver Mattary Gland Salivary Gland Spleen Urinary Bladder -Lobular aass, 2 x 1.5 x 1 ca, in perineal area. -Sinusoidal ectasia, cortex, aild -Not exaained, tissing -Chronic progressive nephropathy, aild Pelvic ainera!izatior,, aild -Portal aononudear cell in filtra te , tild Portal bile duct proliferation, aild Hepatocyte vacuolation, suiti fecal, aild -Fibroadenoaa -Sialadenitis, chronic, aoderate -Heaosiderosis, aild -Not exaained, aissing The -following tissues ere found to be within noreal li* it s : Brain, Spinal Cord, Bone Harrow, Heart, Lung, Stoaach, Stall Intestine, Large Intestine, Aorta, Uterus, Ovary, Pituitary, Trachea, Thyroid, Parathyroid, Esophagus, Lytph Node (aesentenc), Pancreas. Species: Rat Project Nutber: 02S1CR0012 Suaaarized STAR Page: 134 2 9 8 C006S6 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anieal Nuaber: 1R-4658 Sex: Feiale Sroup: ( 5) FC-143 300 ppa Fate: (Ueek= 105) Tereinal Sacrifice Macroscopic Observations: Mastary Gland -- Microscopic Observations: Adrenal Esophagus Heart Kidney Liver Lyeph Node (eesenteric) Maasary Eland Ovary Parathyroid Salivary 61and Spleen Thyroid Trachea - -Milk cyst in perineal area. -Sinusoidal ectasia, cortex, larked -Not exaeined, aissing -Myocarditis, chronic nonsuppurative, u ltifo ca l, ai Id -Chronic progressive nephropathy, cild Pelvic aineraiizatior., ainiaal -Hepatocyte vacuolation, ultifocal, ai Id Megalocytosis, ainiaal -Heaorrhage, aoderate Pigaent, brown, aoderate -Fibrosis, aild -Cyst, unilateral -Not exaained, aissing -Net exaained, aissing -Heaosiderosis, aild -Not exaained, aissing -Not exaained, aissing The following tissues were found to be within noreal lia its : Brain, Spinal Cord, Eone Harrow, Lung, Stoaach,, Snail Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Pituitary, Pancreas, Eye. Ar.iaa! Nuaber: 1R-4E59 Sex'. Fenale Group: ! 3! FC-143 300 ppa Fate: (Keek= 1C5) Terainal Sacrifice Macroscopic Observations: Mateary Eland Microscopic Observations: Adrenal Aorta Esophagus Kidney Liver Lung Maaaary 61and Pancreas -Lobular 3 x 3 ca aass in throat area. -Sinusoidal ectasia, cortex, aoderate -Not exaained, aissing -Not exaained, aissing -Chronic progressive nephropathy, aoderate Pelvic aineralization, ainiaal -Portal aononudear cell in filtra te , ainiaal Portal bile duct proliferation, aild -Vascular aineralization, cild Perivascular aononudear in filtra te , aild -Fibroadenoaa -Acinar atrophy, aild Islet ceil adenoaa Species: Rat Project Nueber: 02B1CR0012 Suaaarized STAR Page: ?99 06S^ Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3N FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4659 Sex: Feaale Broup: ( 5) FC-143 300 ppa Fate: (Week- 105) Terainal Sacrifice Microscopic Observations (continued): Uterus -Polyp The folloaing tissues aere found to be aithin noraal lin t s : Brain, Spinal Cord, Bone Marroa, Spleen, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Ovary, Pituitary, Trachea, Thyroid, Parathyroid, Lyaph Node (aesenteric), Salivary Bland, Eye. Animal Nuaber! 1R-466C Sex: Feaale 6roup: ( 5) FC-143 300 ppa Fate: Week* 105) Terainal Sacrifice Macroscopic Observations: Pituitary Haaaary Gland Microscopic Observations: Adrenal Esophagus Kidney Large Intestine Liver Lung Lyaph Node (aesenteric! Maaeary Gland Fancreas Parathyroid Pituitary Spleen -Mass, 0.6 ca dia. -Hass, 2.5 x 2 x 3 ca, le ft a xilla: aass, 4.4 x 4 x 2 ca, le ft inguinal. -Sinusoidal ectasia, cortex, aarked -Not exaained, aissing -Chronic progressive nephropathy, ainiaal Pelvic aineralizatior., ainiaal -Neaatodiasis, colon -Portal aononudear cell in filtra te , aild Portal bile duct proliferation, aild Hepatocyte vacuclation, aultifocal, ainiaal Cy5tcid degeneration, focal, ainiaal -Alveolar tacrophages, focal, aild -Pigaent, broan, aild -Fibroadenona Fibroadenoaa -Is le t cell carcinosa -Not exaained, not in plane of section -Adenona -Heaosiderosis, ainiaal The folloaing tissues aere found to be aithin noraal. U nits: Brain, Spinal Cord, Bone Narroa, Heart, Stcaach, Saall Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Trachea, Thyroid, Salivary Gland, Eye. Species: Rat Project Nuaber: 0281CR0012 Suaaarized 5TAR Page: 136 300 C006S8 Suanarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4661 Sex: Feaale Group: ( 5) FC-143 300 ppt Fate: (Neek= 105) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Esophagus Kidney Liver Lung Parathyroid -No visible lesions. -Not exaained, aissing -Chronic progressive nephropathy, ainiaal -Portal aononudear cell in filtra te , aild Hepatocyts vacuo!ation, aultifocal, aild -Vascular aineralization, aild Alveolar aacrophages, aultifocal, aild -Not exaained, not in plane of section The follouing tissues Here found to be within noraal lia its : Brain, Spinal Cord, Bone Marron, Spleen, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Maaaary Bland, Pituitary, Trachea, Adrenal, Thyroid, Lyaph Node iaesenteric), Pancreas, Salivary Gland, Eye. Aniaal Number: 1R-4662 Sex: Feaale Group: ( 5! FC-143 300 ppa Fate: (Heek= 105) Terainal Sacrifice Macroscopic Observations: Maaaary Gland Microscopic Observations: Adrenal Esophagus Kidney Liver Lung Lyaph Node (aesenteric) Maaaary Gland Pituitary Spleen -Ulcerated necrotic aass, 4 x 3 ca, in right inguinal area. -Sinusoidal ectasia, cortex, narked -Not exaained, aissing -Chronic progressive nephropathy, aild -Porta! aononudear cell in filtra te , aild -Vascular aineralization, aild Heaorrhage, aultifocal, aild -Pigaent, broan, aoderate -Fibroadenoaa -Adenoaa -Heaatopoiesis, extraaedullary, increased, aarked The following tissues aere found to be within noraal lia its : Brain, Spinal Cord, Bone Marroa, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Trachea, Thyroid, Parathyroid, Pancreas, Salivary Gland, Eye. Species: Rat Project Nuaber: 0281CR0012 000683091Suaaanzed STAR Page: 137 Suaaarized Single Tabulated Anital Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4663 Sex: Feaale Broup: ( 5! FC-143 300 ppt Fate: (Week= 105) Terainal Sacrifice Macroscopic Observations: Maaaary Bland Adrenal Microscopic Observations: Adrenal Hidney Liver Lung Masaary Gland Parathyroid -Mass, 3 x 2.5 ca, in the throat area. -Right adrenal appears saall. -Sinusoidal ectasia, cortex, unilateral, oderate -Chronic progressive nephropathy, aild Pelvic aineralization, aild -Portal aononuclear cell in filtra te , aild Hepatocyte vacuolation, aultifocal, aild Hepatocyte alteration, vacuolated, focal, aild -Alveolar aacrophages, local areas, aild Heaorrhage, aild -Fibroadenoaa -Not exaained, not in plane of section The fcllcaing tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Name*, Spleen, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Pituitary, Trachea, Thyroid, Esophagus, Lyaph Node iaesenteric), Pancreas, Salivary Gland, Eye. Aniaa! Nuaber: 1R-4665 Sex: Feaale Group: i 5) FC-143 300 ppi Fate: !Week= 94) Sacrificed in extreais Macroscopic Observations: Pituitary Maaaary Bland Microscopic Observations: Adrenal Esophagus kidney Liver Lung Lyaph Node (aesenteric) Maaaary Gland Ovary Pituitary Spleen -Raised red aass, 1.2 ca dia. -Saall ailk cyst present. -Sinusoidal ectasia, cortex, aild -Not exaained, aissing -Chronic progressive nephropathy, ainiaal Pelvic aineralization, niniaal -Portal aononuclear cell in filtra te , aild Portal bile duct proliferation, aild -Vascular aine-alization, aild Heaorrhage, local areas, aild -Not exaained, aissing -Lobular hyperplasia, aoderate -Tubular hyperplasia, aoderate -Adenoaa -Heaosiderosis, aild Species'. Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 138 302 000690 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4665 Sex! Feaale Group! ( 5) FC-143 300 ppc Fate: (Week= 94) Sacrificed ir, extreais Microscopic Observations (continued): Uterus -- -Hydroaetra, Barked The follouing tissues cere found to be within noraal lia its : Brain, Spinal Cord, Bone Marroa, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Trachea, Thyroid, Parathyroid, Pancreas, Salivary Bland, Eve. Anisal Nusber: 1R-4S67 Sex! Feaale Group: ( 5) FC-143 300 ppc Fate: (Neek= 105) Tersiral Sacrifice Macroscopic Observations: Pituitary Urinary Bladder Microscopic Observations: Adrenal Esophagus kidney Liver Lung Maasar y Gland Ovary Parathyroid Pituitary Salivary Gland Urinary Bladder -Raised aass, 1.2 ca dia. -Nall appears thickened. -Cortical atrophy, bilateral, aoderate -Not exaained, aissing -Pelvic aineralication, aild -Portal aononuclear cell in filtra te , aild Porta! bile duct proliferation, aild Megalocytosis, aild -Vascular aineralization, aild Pneuaonia, in te rs titia l, chronic, aultifocal, aild Alveolar aacrophages, local areas, aoderate Heaorrhage, local areas, aoderate 6ranuloaa, aultiple -Not exaained, aissing -Tubular hyperplasia, aild -Not exaained, not in plane of section -Adenoaa -Not exaained, aissing -Epithelial hyperplasia, sicple, diffuse, aild Hypertrophy, auscularis, aild The following tissues aere found to be Mithin noraal lia its : Brain, Spinal Cord, Bone Marroa, Spleen, Heart, Stoaach, Saall Intestine, Large Intestine, Aorta, Uterus, Trachea, Thyroid, Lyaph Node (aesenteric), Pancreas, Eye. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized 5TAR Page: 139 303 000691 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: lR-46a8 Sex: Feaale Group: ( 5) FC-143 300 ppa Fate: (eek- 81) Sacrificed in extreais Macroscopic Observations: Fituitarv -- Microscopic Observations: Adrenal Liver Lung Haasary Gland Parathyroid Pituitary Spleen Thyroid Urinary Bladder -Enlarged due to red aass, 1 x 0.8 ca. -Sinusoidal ectasia, cortex, ai 1d -Hepatocyte vacillation, periportal, aoderate -Vascular aineralization, aild Heacrrhage, local areas, aild -Not exanined, aissing -Not exaained, aissing -Adenoaa -Heaosiderosis, aild -Not exaained, aissing -Not exaained, aissing The Following tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Harroa, Kidney, Heart, Stoaach, Saall Intestine, Large Intestine, Aorta, Uterus, Ovary, Trachea, Esophagus, Lyeph Node (aesenteric), Pancreas, Salivary Bland, Eye. Aniaal Nuaber: 1R-4670 Sex: Feaale Group! ( 5) FC-143 300 ppa Fate: (Neel* 92) Sacrificed in extreais Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Kidney Liver Lung Maatary Gland Pituitary Spleen -Raised heaorrhagic aass, 1 ct dia. -Sinusoidal ectasia, cortex, unilateral, aild Medullary-cell hyperplasia, aultifocal, aild -Chronic progressive nephropathy, aild Pelvic aineralization, aoderate -Pigaer.t, Kupfer cell, broan, aild -Alveolar aacrophages, focal, aild Perivascular aononudear in filtra te , ainiaal -Not exaained, aissing -Adenoaa -Heaosiderosis, aild The fc l lowing tissues ere found to be within noraal lia its : Brain, Spinal Cord, Bone Harroa, Heart, Stoaach, Saall Intestine, Large Intestine Urinary Bladder, Aorta, Uterus, Ovary, Trachea, Thyroid, Parathyroid, Esophagus, Lyaph Node (aesenteric), Pancreas, Salivary Eland, Eye. Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page! 140 304 000692 Suaaarized Single Tabulated Aniaal Report (continued! Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Tao Year Oral Toxicity-Qr.cogenicity Study iR Rats Table: 2 Aniaal Nuaber: 1R-4672 Sex: Feaale Group: ( 5) FC-143 300 ppa Fate: (Week- 105) Terainal Sacrifice Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Esophagus Lung Lyaph Node (aesenteric! Ovary Parathyroid Pituitary Salivary Eland Thyroid Trachea - -Haorrhagic aass, 0.9 ca dia. -Sinusoidal ectasia, cortex, ainiaal -Not exaained, Bissino -Heaorrhage, local areas, aoderate -Pigaent, brown, ainiaal -Tubular hyperplasia, unilateral, aoderate -Not exaained, aissing -Adenoaa -Sialadenitis, chronic, aoderate -Not exaained, aissing -Not exaained, aissing The fo l1owing tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Marrow, Spleen, Liver, Kidney, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Haaaary Gland, Pancreas, Eye. Aniaal Nuaber: 1R-4673 Sex: Feaale Group: ( 5) FC-143 300 ppa Fate: (Heek= 79) Sacrificed in extreais Macroscopic Observations: Pituitary Skin Microscopic Observations: Adrenal Liver Lung Haaaary Gland Parathyroid Pituitary Thyroid -Large heaorrhagic aass, 1.5 x 1 ca dia. -Subcutaneous Basses, 1.5 x 1.5 x 1 ca, right axilla; 3.5 x 3 x 2 ca le ft axilla. -Sinusoidal ectasia, cortex, aild -Portal aononuclear cell in filtra te , aild Portal bile duct proliferation, aild -Vascular cineralization, aild -Adenocarcinoaa Galactocele Lobular hyperplasia, aoderate One of the grossly described aasses was an area of galactocoels and lobular hyperplasia. -Not exaained, aissing -Adenoaa -Not exaained, aissing The following tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Marrow, Spleen, Kidney, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus,, Ovary, Trachea, Esophagus, Lyaph Node (aesenteric), Pancreas, Salivary 61and, Eye. Species: Rat Project Nuaber: 0281 CROC12 Suaaarized STAR Page: M l 3 0 5 000693 Suaaarized Single Tabulated Aniaal Report (continued) Individual Hacroscopic and Hicroscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4675 Sex: Feaale Group: ( 5) FC-143 300 ppa Fate: (Neek= 105) Terainal Sacrifice Hacroscopic Observations: Lung - Kidney Hicroscopic Obser vatior,s: Adrenal Esophagus Heart Kidney Liver Lung Parathyroid Pituitary - -Apparent areas of consolidation. -5oaewhat pale and pitted. -Sinusoidal ectasia, cortex, aoderate Cortical vacuolation, aild -Not exaained, aissing -Hyocarditis, chronic nonsuppurative, local areas, aild -Chronic progressive nephropathy, aoderate -Portal aononudear cell in filtra te , aild Hegalocytosis, ainiaal -Vascular aineralization, aild 6ranuloaa, diffuse, aarked Large area of granuloaa with aany giant cells. Few fragaents of foreign aaterial present. -Not exaair.ed, not in plane of section -Adenoaa The following tissues were found to be within noraal b a its : Brain, Spinal Cord, Bone Harrow, Spleen, StDcach, Saall Intestine, Large Intestine, 'urinary Bladder, Aorta, Uterus, Ovary, Haaaary Bland, Trachea, Thyroid, Lyaph Node (aesenteric), Pancreas, Salivary 61and, Eye. Aninal Number: 1R-4677 Sex: Feaale 6roup: ( 5) FC-143 300 ppa Fate: (Heek= 105) Terainal Sacrifice Hacoscopic Observations: Haaaary Bland Hicroscopic Observations: Adrenal Esophagus Kidney Liver Lung -Hass, 2 x 1.5 ca, in le ft axilla: aultilobular aass, .5 x 5.5 x 2 ca, in perineal area. -Cortical vacuolation, aild Sinusoidal ectasia, cortex, aild -Not exaained, aissing -Pigaent, conv. tub. epitheliue, brown. ainiaal -Portal aononudear cell in filtra te , aoderate Portal bile duct proliferation, aoderate Hegalocytosis, ainiaal -Vascular aineralization, aild Species: Rat Project Nuaer: C2B1CR0012 306Suaaarized STAR Page: 142 G00694 Suuarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nuiber: 1R-4677 Sex: Feiale Group: ( 5) FC-143 300 ppi Fate: (Week- 105! Teriina! Sacrifice Microscopic Observations (continued): Lyiph Node tiesenterich Haisary Gland Ovary Pituitary -Sinusoidal ectasia, derate -Fibroadenoia Fibroadenoaa -Tubular adenoia, unilateral -Adenoia The following tissues were found to be within norial lin t s : Grain, Spinal Cord, Bone Marrow, Spleen, Heart, Stoiach, Stall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Trachea, Thyroid, Parathyroid, Pancreas, Salivary Gland, Eye. Anita! Nuiber: 1R-4&7B Sex: Feiale 6roup! 1 5) FC-143 300 ppi Fate-. (Neek= 49! Sacrificed in extreiis Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Kidney Liver Lung Parathyroid Pituitary Spleen Urinary Bladder -Enlarged due to lass, 1 x 0.7 ci. -Sinusoidal ectasia, cortex, aild -Pelvic lineralization, aild -Portal tonDnucJear cell in filtra te , lild Hepatocyte vacuolation, local areas, tild -Vascular lineralization, aild Perivascular lononudear in filtra te , tild Hetorrhage, local areas, toderate -Not exaiined, not in plane of section -Adenoia -Heiosiderosis, iiId -Not exaiined, lissing The following tissues were found to be within norial l i i i t s : Brain, Spinal Cord, Gone Marrow, Heart, Stoiach, Siall Intestine, Large Intestine, Aorta, Uterus, Ovary, Maiiary Gland, Trachea, Thyroid, Esophagus, Lyiph Node liesenteric), Pancreas, Salivary Gland, Eye. Aniial Nuiber: 1R-4B79 Sex: Feiale Group: ( 5! .FC-143 300 pps Fate: (Neek= 105! Teriinal Sacrifice Macroscopic Observations: Pituitary Maiiary Gland -Raised heiorrhagic lass, 0.5 ci dia. -Nodular iass, 1 c i dia., in le ft axilla; large iass, 5 x 5 ci, in right inguinal area. Species: Rat Project Nuiber: 0281CR0012 Suiiarned STAR Fane: 143 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 311 FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4679 Sex: Fetale Group: ( 5! FC-143 300 ppa Fate: (Neek= 105) Terairal Sacrifice Microscopi: Observations (continued): Adrenal Esophagus Kidney Liver Lung Haaaary Gland Ovary Pituitary Thyroid Uterus -Cortical vacuolation, aoderate Sinusoidal ectasia, cortex, aoderate Nodular hyperplasia, cortex, focal, aoderate -Not exaained, aissing -Chronic progressive nephropathy, aarked -Portal bile duct proliferation, aild -Pneutonia, in te rs titia l, chronic, focal, ainiaal Alveolar aacrophages, focal, aild Perivascular aononuclear in filtra te , aild Heaorrhage, local areas, aoderate -Fibroadenoaa -Tubular hyperplasia, bilateral, aild -Adenera -Ultiaobranchial cyst -Cystic glands, ainiaal The folloaing tissue; ere found to be within norsal lia its : Grain, Spinal Cord, Gone Harrow, SplEen, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Trachea, Parathyroid, Lyaph Node (aesenteric), Pancreas, Salivary Gland, Eye. Aniaal Nunber: 1R-4GB0 Sex: Feaale 6roup: ( 5) FC-143 300 ppa Fate: (Heek= 104) Found Dead Hacroscopic Observations: Haaaary Gland Pituitary Liver Microscopic Observations: Adrenal Eye Heart Kidney Large Intestine Liver Lung Lyaph Node (aesenteric) -Large aass, 9 x 9 x 3.5 ce, in le ft inguinal area. Hass had necrotic, heaorrhagic surface. -Dark lesion, 0.4 ca dia. -Pale -Sinusoidal ectasia, cortex, aild -Not exaained, aissing -Myocarditis, chronic nonsuppurative, local areas, aild -Pelvic aineralization, ainiaal -Not exaained, aissing -Necrosis, centrilobular, aarked -Vascular aineralization, aild -Not exaained, aissing Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 144 308 000696 Suaaarized Single Tabulated Anna! Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Vear Oral Toxicity-Oncogenicity Study in Rats Table: 2 Amaal Nuaber: 1R-46B0 Sex: Feeale Group: ( 5) FC-143 300 ppi Fate: (Week= 104) Found Dead Microscopic Observations (continued): Naeaary Bland Ovary Parathyroid Pituitary Stall Intestine Uterus Lyaphangiosarcoaa Large well differentiated tutor with nuaercus eoderate to large size spaces containing few lyaphocytes. -Tubular hyperplasia, aoderate -Rot exaained, not in plane of section -Adenoaa -Not exaained, aissing -Not exaained, aissing The f cl lowing tissues were found to be within norcal lin t s : Brain, Spinal Cord, Bone Marrow, Spleen, Stoaach, Urinary Bladder, Aorta, Trachea, Thyoid, Esophagus, Pancreas, Salivary 61and. finiaal Nuafcer: 1R-46B1 Sex: Fetale Group: ( 51 FC-143 300 ppi Fate: (i4eek= 97! Sacrificed in extreais Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Esophagus Kidney Liver Lung Ovary Pancreas Parathyroid Pituitary Spleen -Heaorrhagic aass, 1.2 ca dia. -Sinusoidal ectasia, cortex, aoderate -Not exaained, aissing -Pelvic aineralization, ainiaal Pyelitis, acute, unilateral, aoderate -Hepatocyte vacuolation, aultifocal, wild -Vascular aineralization, aild Alveolar aacrophages, focal, ainiaal Perivascular aononudear in filtra te , ainiaal Heaorrhage, focal, aild -Tubular hyperplasia, aoderate -Acinar atrophy, aild -Not exaained, not in plane of section -Adenoaa -Heaosiderosis, aild The fclloMing tissues were found to be within noraal lia its : Brain, Spinal Cord, Gone Marrow, Heart, Stoaach, Stall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Hataary Gland, Trachea, Thyroid, Lyaph Node (aesenteric), Salivary Gland, Eye. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page|_145 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-46E2 Sex: Feaale Broup: < 5) FC-143 300 ppa Fate: (Meek- 94) Found Dead Macroscopic Observations: Haaaary Bland -- Microscopic Observations: Adrenal Esophagus Eye Large Intestine Lung Lysph Node (aesenteric) Canary Bland Ovary Pancreas Parathyroid Pituitary Salivary 61ar.d Seal 1 Intestine Stoaach Thyroid Urinary Bladder Uterus -- -Large aultilobular aass, 1 1 x 9 * 6 ca, in le ft axilla. -Sinusoidal ectasia, cortex, aarked -Not exaained, aissing -Not exaained, aissing -Not exaained, aissing -Vascular aineralization, ai Id Alveolar aacrophages, a u ltifocal, aild -Not exaained, aissing -Fibroadenoaa -Not exaained, aissing -Not exaained, aissing -Not exaained, aissing -Adenoaa -Not exaained, aissing -Not exaained, aissing . -Not exaained, aissing -Not exaained, aissing -Not exaained, aissing -Not exaained, aissing The fallowing tissues aere Found to be within noraal lia its : Brain, Spinal Cord, Bone Marrow, Spleen,, Liver, Kidney, Heart, Aorta, Trachea. Aniaal Nuaber: 1R-46B3 Sex: Feaale Broup: ( 5) FC-143 300 ppa Fate: !Neek= 105) Terainal Sacrifice Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Esophagus Liver Lung Ovary Parathyroid Pituitary -Mass, 0.5 ca dia. -Sinusoidal ectasia, cortex, aoderate Adenora, cortical, unilateral -Not exaained, aissing -Portal aononuclear cell in fi 1trate, aild -6ranuloaa, a u ltifocal, aild Foreign aaterial in soae granulosas. Heaorrhage, local areas, aild -Tubular hyperplasia, bilateral, aoderate -Not exaained, not in plane of section -Adenoaa Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR PagE! 146 ^ ] C00S98 Suttarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anita! Nutber: 1R-46B3 Sex: Fetale Group: ( 5) FC-143 300 ppa Fate: (Week= 105) Tertinal Sacrifice Microscopic Observations (continued): The following tissues were found to be within nornal l i i i t s : Brain, Spinal Cord, Bone Marrow, Spleen, Kidney, Heart, Stoiach, Stall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Mataary Bland, Trachea, Thyroid, Lytph Mode iieser.teric), Pancreas, Salivary Bland, Eye. Aniial Nutber: 1R-4684 Sex: Fetale Group: ( 5) FC-143 300 ppt Fate: (Week- 103! Found Dead Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Aorta Esophagus Lung Lytph Node (tesenteric) Mattary Bland Ovary Parathyroid Pituitary Salivary Bland Thyroid Trachea Unidentified Tissue -Raised, hetorrhagic, 0.1 ct dia. -Not exatined, tissing -Not exatined, tissing -Not exatined, tissing -Vascular tineralizaticn, tild -Not exatined, tissing -Not exatined, tissing -Tubular hyperplasia, toderate -Not exatined, tissing -Adenota -Not exatined, tissing -Not exatined, tissing -Not exatined, tissing -Lipota Large necrotic tutor of adipose tissue. unspecified. Site The following tissues were found to be within nornal l i i i t s : Brain, Spinal Cord, Bone Marrow, Spleen, Liver, Kidney, Heart, Stotach, Stall Intestine, Large Intestine, Urinary Bladder, Uterus, Pancreas, Eye. Anita! Nutber: 1R-46B5 Sex: Fetale Broup: ! 5) FC-143 300 ppt Fate: IHeek= 75) Sacrificed in extretis Macroscopic Observations: Haiiary Bland Adrenal Microscopic Observations: Adrenal -Large tass, 15 x 9 x 4 ct, sonewhat f i n and nultilobular. -Both appeared enlarged with dark foci. -Sinusoidal ectasia, cortex, toderate Species: Rat Project Nutber: 02B1CR0012 Suttariied STAR Page: 147 3 1 I 000699 Suttarized Single Tabulated Aniial Report (continued) Individual Hacroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Too Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 il Nutber: 1R-46B5 Sex: Feiale Group: ( 5) FC-143 300 ppc ; (Heek= 75) Sacrificed in extretis Hicroscopic Observations (continued): Esophagus Kidney Liver Lung Haatary 61and Salivary Gland Spleen - -Not exaained, aissing -Pelvic iineralization, tanked -Necrosis, tultiFocal, tild Heaatcpoiesis, extraiedullary, toderate -Vascular Mineralization, tild Alveolar tacraphages, Focal, tin ita l Hetorrhage, local areas, toderate -Fibroadenota -Not exaained, aissing -Heaatopoiesis, extraiedullary, increased, tild The following tissues were Found to be within noraal lin t s : Brain, Spinal Cord, Bore Narrow, Heart, 5toaach, Seal 1 Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Pituitary, Trachea, Thyroid, Parathyroid, Lyeph Rode (aesenteric), Pancreas, Eye. Aniaal Nuaber: 1R-46S6 Sex! Feaale Group: ( 5) FC-143 300 ppa Fate: (Heek= 105) Terainal Sacrifice Macroscopic Observation:;: Pituitary Rataary Gland Liver Microscopic Observations: Adrenal Esophagus Liver Ramary P:tu:ta* -Saall heaorrhagic aass, 0.3 ca dia. -Large aultilobular aass, 10 x 7 x 4 ca, in right axilla. -Hass, 5 ir 3 ca, in right lateral lobe. -Sinusoidal ectasia, cortex, n r i i -Rot exaained, aissing -Portal bile s *;i prcliFe-atior, tild Hepatccallular carcinota -Alveclar aacrophages, Focal, tile Perivascular aor.onuclear inFiltrate, tin ita l Hescrhage, local areas, aiid -Fibroader.oaa -Adenosa The Following tissues we-e Found to be within nornal liitits : Brain, Spinal Cord, Bone Harrow, Spleen, Kidney, Heart, Stoaach, Stall Intestine, La'ge Intestine, Urinary Bladder, Aorta, Utems, Ovary, Trachea, Thyroid, Parathyroid, Lyaph Node iiesenteric), Pancreas, Salivary Gland, Eve. Species: Rat Project Nutter; 02B1ZR0012 Suaianzed STAR Page: 14E 3 1 2 000700 5utaarized Single Tabulated Anita! Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tec Vear Oral Toxicity-Oncogenicity Study in Rats Table: 2 Ani3 Nutter: 1R-46B3 Sex: Fetale Broup: ( 5) FC-143 300 ppe Fate: (week- 105! Tenir,al Sacrifice Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Heart Kidney Large Intestine Massary Bland Ovary Pituitary Spleen -Mass, 0.9 ci dia. -Sinusoidal ectasia, cortex, l i Id -Myocarditis, chronic nonsuppurative, u ltifocal, aild -Ch'onic progressive nephropathy, aild -Neiatodiasis, colon -Not exaained, ai ssi ng -Tubular hyperplasia, derate -Adenona -Heiosiderosis, aild The following tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Marrow, Liver, Lung, Stoaach, Saall Intestine, Urinary Bladder, Aorta, Uterus, Trachea, Thyroid, Parathyroid, Esophagus, Lyaph Node (aesenteric), Pancreas, Salivary Bland, Eye. Aniaal Nuater: 1R-469 Sex! Feaale Broup: ( 5) FC-143 3C0 ppa Fate: (Week= 105) Terainal Sacrifice Macroscopic Observations! Microscopic Observations: Adrenal Kidney Liver Lung Lyaph Node (aesenteric) Parathyroid Thyroid -No visible lesions. -Sinusoidal ectasia, cortex, unilateral, aarked -Chronic progressive nephropathy, aild -Hepatocyte vacuolation, aultifocal, aild -Vascular liners!ization, aild Pneuaonia, in te rs titia l, chronic, aultifocal, aild Alveolar aacrophages, local areas, aild -Pigaent, brown, aild -Not exaained, not in plane of section rUltieobranchial cyst The following tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Narrow, Spleen, Heart, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Naaiary Gland, Pituitary, Trachea, Esophagus, Salivary 6!and, Eye, Pancreas. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 149 3 1 3 000701 Suaaarized Single Tabulated ftniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-I43: Two Year Oral Toxicity-Oncogenicity Study in Rats fable: 2 Aniaal Nuiber: 1R-4691 Sex: Fetale Group: ( S) FC-143 300 ppt Fate: (kieek= 100) Sacrificed in extreais Macroscopic Observations: Liver Adrenal Microscopic Observations: Adrenal Heart kidney Liver Lung Pancreas Spleen Stotach Thyroid Urinary El adder -Appear enlarged with ultiple pale foci in all lobes. -Left adrenal appears enlarged. -Cortical vacuolation, local areas, aild Sinusoidal ectasia, cortex, unilateral, tarked -Myocarditis, chronic nonsuppurative, ultiFocal, aild -Chronic progressive nephropathy, ainital Protein resorption droplets, tubular, larked -Malignant lyaphota, histiocytic -Vascular aineralization, aild Malignant lyaphota, histiocytic Keaorrhage, local areas, tild -Edeaa, in te rs ititia l, acderate -Heaatopoiesis, extraaedullary, increased, coderate -Edeaa, subaucosal, acderate -Hyperplasia, C cell, focal, aild -Malignant lyaphoaa, histiocytic The following tissues were found to be within noraal lia its : Brain, Spinal Cord, Bone Marrow, Saall Intestine, Large Intestine, Aorta, Uterus, Dvary, Massary Gland, Pituitary, Trachea, Parathyroid, Esophagus, Lyaph Node (aesenteric), Salivary Gland, Eye. Aniaal Nutber: 1R-4693 Sex: Feaale Group: ( 5) FC-143 300 ppa Fate: (Heek= 105) Terainal Sacrifice Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Kidney Liver Lung Pituitary -Dark raised lesion, 0.3 ca dia. -Sinusoidal ectasia, cortex, aarked -Pelvic aineralization, aild -Hepatocyte vacuolation, aultifocal, aild -Pneuaonia, in te rs titia l, chronic, local areas, aild Alveolar aacrophages, local areas, aild Perivascular aononuclear in filtra te , aild -Adenoaa Species: Rat Project Nuaber: C2G1CR0012 Suaaarized STAR Page: 150 3 1 4 Suttarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Piker Laboratories, Inc. 3H FC-143: Tto Year Oral Toxicity-Oncogenicity Study ir. Rats Table: 2 Aniial Nutber: 1R-4B93 Sex: Feiale Group: ( 5) FC-143 300 ppi Fate: (Keek= 105) Terminal Sacrifice Microscopic Observations (continued): The following tissues ere found to be within ncrital 1iAits: Brain, Spinal Cord, Bone Marrow, Spleen, Heart, Stoaach, Stall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Mattary Gland, Trachea, Thyroid, Parathyroid, Esophagus, Lytph NcdE (tesenteric), Pancreas, Salivary 61and, Eye. Aniial Nutber: 1R-4694 Sex: Feiale Group: 1 5) FC-143 300 ppi Fate: (Neek= 105) Terainal Sacrifice Macroscopic Observations: Fituitary Maotary Gland Microscopic Observations: Adrenal Kidney Lung Mattary Gland Ovary Parathyroid Pituitary Spleen -Raised tass, 1.2 ci dia. -Stall nodular lesion, 0.6 ci dia., in right axilla; possible t ilk cyst. -Sinusoidal ectasia, cortex, tarked -Chronic progressive nephropathy, tild Pelvic tineralization, tin ita l -Alveolar tacrophages, tu ltifo c a l, tild -Fibroadenota -Cyst, unilateral -Not exatined, not in plane of section -Adenota -Hetcsidercsis, loderate The following tissues nere found tc be within norial l i i i t s : Brain, Spinal Cord, Bone Macon, Liver, Heart, Stoiach, Stall Intestine, Lange Intestine, Urinary Bladder, Aorta, Uterus, Trachea, Thyroid, Esophagus, Lytph Node (tesenteric), Pancreas, Salivary Gland, Eye. Anital Nutber: 1R-4695 Sex: Fetale Group: ( 5) FC-143 300 ppt Fate: (Neek= 105) Tertinal Sacrifice Macroscopic Observations: Pituitary Mattary Gland Liver Microscopic Observations: Adrenal Kidney -Hetorrhagic tass, 0.8 ci dia. -Lobular cystic tass, 4.5 x 3 x 2 ct, in le ft axilla. -Hass, 3.5 x 3 x 2 cn, in tedian lobe. -Sinusoidal ectasia, cortex, unilateral, tarked -Chronic progressive nephropathy, tild Pelvic tineralization, t ild Species: Rat Project Nuaber: 02B1CR0012 Suttarized STAR Page! 151 3 1 000703 Sueaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3N FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nueber: 1R-4695 Sex: Fetale Group: ( 5) FC-143 300 ppi Fate: (Neek= 105) Terainal Sacrifice Microscopic Observations (continued): Liver Maaaary Gland Pituitary Uterus -Portal ononudear cell in filtra te , aild Hepatocyte vacuolation, aultifocal, aild Hyperplastic nodule Large lesion with extensive cystoid degeneration within nodule. -Perivascular aononuclear in filtra te , ainiaai -Fibroadenoaa Adenocarcinoaa Adenocarcinoaa arises in fibroadenoaa. -Adenoca -Cystic glands, aild The following tissues were found to be within norcal lia its : Brain, Spinal Cord, Gone Marrow, Spleen, Heart, Stoaach, Stall Intestine, Large Intestine, Urinary Bladder, Aorta, Ovary, Trachea, Thyroid, Parathyroid, Esophagus, Lyaph Node (aesenteric), Pancreas, Salivary Eland, Eye. Aniaal Nueber: 1R-4696 Sex: Fetale Group: ( 5) FC-143 300 ppa Fate: (Neek= 105) Terainal Sacrifice Macroscopic Observations: Maaaary 61and Lyaph NGde (aesenteric) Microscopic Observations: Adrenal kidney Liver Lung Lyaph Node (aesenteric) Maaaary 61and -Lobular aass, 5.5 x 4.5 x 2.5 ca, le ft axilla; aultilobular aass, 5.5 x * x 2 ca, in perineal and le ft inguinal area. -Large and cystic. -Sinusoidal ectasia, cortex, aild -Chronic progressive nephropathy, aild -Hepatocyte alteration, vacuolated, local areas, aild Negaiocytosis, ainiaai Hepatocyte alteration, basophilic, focal, aild -Perivascular aononuclear in filtra te , ainiaai Heaorrhage, local areas, eild Granulosa, local areas, aild -Sinusoidal ectasia, aarked Granulosa, aesentery -Fibroadenoaa Adenocarcinoaa Species: Rat Project Nueber: 0281CR0012 Suaaarized STAR Page: 152 3 C00704 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 An;al Nuaber: 1R-469A Sex: Fetale Group: ( S) FC-143 300 ppi Fate: (Week= 105! Terminal Sacrifice Microscopic Observations (continued): Ovary Pituitary Siali Intestine Thyroid -Cyst, unilateral -Adenoia -Grand oaa, eesentery -Hyperplasia, C cell, focal, iiId The following tissues were found to be within noraal lin t s : Erain, Spinal Cord, Bone Marrow, Spleen, Heart, Stoeach, Large Intestine, Urinary Bladder, Aorta, Uterus, Trachea, Parathyroid, Esophagus, Pancreas, Salivary Gland, Eye. Aniiai Husoer: 1R-4S97 Sex: Feeale Group: 5) FC-143 300 ppa Fate: (Weeks 105) Teriinal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Kidney Lung Pituitary Thyroid Uterus -No visible lesions. -Sinusoidal ectasia, cortex, aoderate -Hydronephrosis, unilateral -Vascular aineralization, aild Perivascular aononudear in filtra te , cild -Adenoaa -Hyperplasia, C cell, focal, aild -Cystic glands, aoderate The following tissues wer e found to be within noraal lin t s : Brain, Spinal Cord, Bone Marrow, Spleen, Live , Heart, Stosach, Snail Intestine, Large Intestine, Urinary Bladder, Aorta, Ovar ', Maasary Gland, Trachea, Parathyroid, Esophagus, Lyaph Node (aesenterid, Pancreas, Salivary G and, Eye. Aniaal Nuaber: 1R-4A92 Sex: Feaale Group: ( 51 FC-143 300 ppa Fate: (Week= 105) Terainal Sacrifice Macroscopic Observations: Pituitary Haaaary Bland Microscopic Observations: Kidney Liver Lung -Hass, 0.5 ca dia. -Mass, 4 x 3.5 x 3 ca, le ft inguinal. -Chronic progressive nephropathy, aild Pelvic aineralization, aild -Portal aononudear cell in filtra te , ainiial Hepatocyte vacuolation, aultifocal, aild Megalocytosis, ainiaal -Vascular aineralization, aild Perivascular aononudear in filtra te , aild Species: Rat Project Nuaber: 0281CR0012 Suiaarized STAR Page: 153 3 000705 Suitarized Single Tabulated Anital Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nutber: 1R-4698 Sex: Feiaie Sroup: ( 5) FC-143 300 ppi Fate: (Meek1 105) Teriinal Sacrifice Microscopic Observations (continued): Mattery Eland Ovary Pituitary - -Flbroadenoia -Cyst, unilateral Tubular hyperplasia, oberate -Adenota The following tissues were found to be within noraa! l i i i t s : Brain, Spinal Ccrd, Bone Marrow, Spleen, Heart, Stoiach, Stall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Trachea, Adrena1, Thyroid, Parathyroid, Esophagus, Lytph Nose iieser.terici, Pancreas, Salivary Eland, Eye. Anital Nusber: 1R-4700 Sex: Feoale Sroup: ( 5) FC-143 300 ppc Fate: (Neek= 96) Sacrificed in extreeis Macroscopic Observations: Maeiary 61and Heart Adrenal Kidney Microscopic Observations: Adrenal Aorta Heart Kidney Lung Lyaph Node (tesenteric! Maeiary 61and Ovary Parathyroid Stall Intestine Stoaach Thyroid -Mass, 3 x 2 ct, in le ft axilla. -Appears possibly enlarged. -Right adrenal appears enlarged. -Pale and pitted. -Sinusoidal ectasia, cortex, unilateral, tarked Cortical degeneration, unilateral , tarked Cortical atrophy, unilateral, icderate -Not examined, tissing -Myocardial fibrosis, local areas, tild -Chronic progressive nephropathy, larked -Pneutonia, in te rs titia l, chronic, diffuse, tarked -Not exatined, tissing -Fibroadenota -Tubular hyperplasia, tarked -Not exatined, tissing -Edeta, latina propria , jejunut, tild -Ecesa, subtucosal, oberate -Not exatined, tissing The following tissues were found to be within norial l i i i t s : Brain, Spinal Cord, Bone Marrow, Spleen, Liver, Large Intestine, Urinary Bladder, Uterus, Pituitary, Trachea, Esophagus, Pancreas, Salivary Bland, Eye. Species: Rat Project Nuiber: 0281CR0012 Suttarized STAR Page: 154 3IO C-00706 Sueearized Single Tabulated Anieal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Teo Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anieal Nusber: 1R-4701 Sex: Feeale Group: ( 5) FC-143 30C ppe Fate: (Heek= 105) Teriinal Sacrifice Macroscopic Observations: Pituitary . .. Microscopic Observations: Adrenal Liver Lung Parathyroid Pituitary -Heeorrhagic eass, 0.5 ce dia. -Sinusoidal ectasia, cortex, eiId -Hepatocyte vacuolaticn, eultifccal, einieal Megalocytosis, einieal -Pneueonia, in te rs titia l, chronic, focal, eiId Alveolar aacrophages, focal, eild -Net exaeined, not in plane of section -Adenoea The following tissues were found to be within noreal U nits: Brain, Spinal Cord, Bone Harrow, Spleen, Kidney, Heart, Stceach, Seall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Maenary Gland, Trachea, Thyroid, Esophagus, Lyeph Node (tesenteric), Pancreas, Salivary Gland, Eye. Anieal Nueber: 1R-4702 Sex: Fesale Group: ! 5) FC-143 300 ppe Fate: (Keek* 67) Sacrificed in extreeis Macroscopic Observations: Pituitary Maaeary Gland Liver Microscopic Observations: Esophagus Heart Kidney Liver Lung Haeeary Gland Ovary Pancreas Pituitary -Reddish eass, 1.2 x 0.S ce. -Lobulated eass, 3 x 2 x 1 ce, in le ft axillary region. -Mottled and slightly pale. -Not exaeined, eissing -Myocarditis, chronic nonsuppurative, eultifocal, eild -Chronic progressive nephropathy, einieal Pelvic eineralization, einieal Pyelitis, acute, unilateral, eild -Hepatocyte vacuolation, periportal, eoderate -Vascular eineralizaticn, eild Heecrrhage, eultifocal, eild -Adenccarcinoea -Tubular hyperplasia, eoderate -Not exaeined, eissing -Adenoea The following tissues Mere found to be within noreal lia its : Brain, Spinal Cord, Bone Harrow, Spleen, Stoeach, Seall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Trachea, Adrenal, Thyroid, Parathyroid, Lyeph Node (eesenteric), Salivary Gland, Eye. Species: Rat Project Nueber: 02B1CR0012 Sueearized STAR Page: 155 3 19 00707 Suiaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3N FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4703 Sex: Feaale Group: ( 5! FC-143 300 ppa Fate: (Week= ICS) Teraina! Sacrifice Macroscopic Observations: Maeaary Gland Microscopic Observations: Adrenal Esophagus Heart Kidney Liver Lung Maaaary Gland Pancreas Pituitary -Lobular aass, 3 x 2 ca, in perineal area. -Sinusoidal ectasia, cortex, aarked -Not exaained, aissing -Myocarditis, chronic nonsuppurative, aultifocal, aild -Chronic progressive nephropathy, aild -Hepatocyte vacuolation, aultifocal, ainiaal Hepatocyte alteration, vacuolated, aultifocal, aild -Pneuaonia, in te rs titia l, chronic, local areas, aild Alveolar aacrophages, local areas, aild -Lobular hyperplasia -Hyperplasia, is le t cell, aild -Adencaa The following tissues were found to be withig noraal H alts: Brain, Spinal Cord, Bore Marrow, Spleen, Stoaach, Saall Intestine, Large Intestine, Urinary Bladder, Aorta, Uterus, Ovary, Trachea, Thyroid, Parathyroid, Lyeph Node iaesenteric), Salivary Gland, Eye. Ar.iaal Nuaber: 1R-47C5 Sex: Feaale Group! ( 5) FC-143 300 ppa Fate: (Weeks 2) Found Dead Macroscopic Observations: Pituitary Microscopic Observations: Esophagus Eye Heart Liver Lung Salivary Gland Urinary Bladder -Tao saall heaorrhagic lesions approxiaately 0.1 ca dia. -Not exaained, aissing -Not exaained, aissing -Myocarditis, chronic nonsuppurative, aultifocal, aild -Hepatocyte vacuolation, aultifocal, aild Megalocytosis, ainiaal -Vascular raneraliration, aild -Not exaained, aissing -Not exaained, aissing The following tissues aere found to be within noraal lia its : Spinal Cord, Bone Marrow, Stoaach, Stall Intestine, Large Intestine, Aorta, Uterus, Ovary, Maaaary Gland, Pituitary, Trachea, Adrenal, Thyroid, Parathyroid, Lyeph Node (aesenteric), Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page: 156 320 000708 Summed Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tko Year Oral Toxicity-Oncogenicity Study in Rats Aniial Nuiberl 1R-4705 Sex: Feiale Group: ( 5) FC-143 300 ppe Fate: (Ueek= 2) Found Dead Microscopic Obser vations (continued): The follow!r.g tissues were found to be within nonal l i i i t s (continued): Pancreas, Brain, Spleen, Kidney. Table: 2 Species: Rat Project Nuiber: 02B1CR0012 321Sunarized STAR Page: 157 000709 Suaaarized Single Tabulated Aniaal Report Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Tear Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuiber: 1R-3646 Sex: Male Group: ( 6) FC-143 30 ppi Fate: (Week: 106) Terainal Sacrifice Macroscopic Observations: Liver Microscopic Observations: Hea-t kidney Liver Lung Pancreas Salivary Eland Thyroid -Possibly pale, lottled. -Myocardial fibrosis, ai 1d Myocarditis, chronic nonsuppur ative, ai Id -Chronic progressive nephropathy, ai Id -Portal onor.uclear cell in filtra te , ai id Portal bile duct proliferation, aild Hepatocyte vacuolation, aultifocal, ainiial Hepatccyte alteration, vacuolated, focal, ild -Vascular aineralization, cild -Not exaained, aissing -Sialadenitis, chronic, aarked -Hyperplasia, C cell, focal, aild The following tissues were found to be within noraal lia its : Spleen, Testis/Epididyais, Prostate, Stoaach, Urinary Bladder, Adrenal, Parathyroid, Trachea, Esophagus, Pituitary. Aniaal Nuaber: 1R-3647 Sex: Male Group: ! 6) FC-143 30 ppa Fate: (Meek* 101) Sacrificed in extreais Macroscopic Observations: Pituitary Skin Stoaach Microscopic Observations: Heart Kidney Liver Lung Pituitary Skin Stoaach Testis/Epididyais -Raised heaorrhagic aass, 0.6 ca dia. -Raised ulcerated lesions on both hind footpads. -Possible area of ulceration in cardia. -Myocarditis, chronic nonsuppurative, aultifocal, aild -Chronic progressive nephropathy, acderate Pelvic aineralization, aild -Portal acnonuclear cell in filtra te , aild -Vascular aineralization, aild Alveolar aacrophages, aultifocal, aild Heaorrhage, aultifocal, aild -Adenoaa -Pododeraatitis, ulcerative, bilateral, aarked -Ulcer, aarked -Tubule atrophy, asperaatogenesis, aild Vascular aineralization, cild Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page: 158 3 2 2 000710 Suisarized Single Tabulated Anital Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anita! Nutber: 1R-3647 Sex: Male Group: ( 6) FC-143 30 ppe Fate! (Week= 101) Sacrificed in extreiis Microscopic Observations (continued): Urinary Bladder - -Epithelial hyperplasia, sitple, diffuse, tiled Epithelial hyperplasia, papillary, local areas, t i 1d Calculus The following tissues were found to be within norcal l i t i t s : Spleen, Prostate, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Anita! Nutber: 1R-3648 Sex: Male 6roup: i 6! FC-143 30 ppt Fate: (Week* Sfc) Sacrificed in extretis Macroscopic Observations: Thyius Liver Spleen Lytph Node (abdetina!) Microscopic Observations: Kidney Liver Lung Lytph Node (abdotinal! Pancreas Pituitary Sp! een Thytus -Lobulated, light-green tass, 2.5 x 1 ct, in th/ius area. -Possibly slightly pale. -Enlarged -Renal, internal ilia c lytph nodes slightly enlarged and lig h t greenish in color. -Leuketia, tyeloid Protein resorption droplets, tiId Extensive in filtra tio n of proliferating cells of early tyeloid series in hi 1us. -Leuketia, tyeloid -Leuketia, tyeloid Heaorrhage, tu ltifo c a l, tiId -Leuketia, tyeloid -Not exatined, aissing -Not exatined, tissing -Leuketia, tyeloid -Leuketia, tyeloid The following tissues were found to be within nortal l i t i t s : Heart, Testis/Epididyiis, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary 61and. Species: Rat Project Nutber: 02B1CR0012 Sutaarized STAR Page: 159 3 2 3 000711 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Tao Vear Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-3649 Sex: Hale Broup: ( FC-143 30 ppa Fate: (Keek: 106) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Kidney Lung Pancreas Pituitary Salivary Eland Thyroid -No visible lesions. -Medullary cell hyperplasia, aultifocal, wild -Chronic progressive nephropathy, ai Id -Vascular ainEralization, wild -Acinar atrophy, aild -Hyperplasia, aultifocal, pars distalis, aild -Sialadenitis, chronic, aoderate -Hyperplasia, C cell, aultifocal, aoderate Ultiacbranchial cyst The feiloising tissues aere found to be within non il H alts: spleen, Liver, Heart, Testis/Epididyiis, Prostate, Stoaach, Urinary Bladder, Parathyroid, Trachea, Esophagus. Aniaal Nuaber; 1P-26C0 Sex: Male Group: ( 6) FC-143 30 ppa Fate: (Hsek= 106) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Kidney Liver Lung Pancreas Salivary Sland -No visible lesions. -Cortical degeneration, focal, aoderate Pheochroaocytoas, aalignant, unilateral Neoplastic cells highly pleoeorphic. -Chronic progressive nephropathy, aoderate -Portal aonanudear cell in filtra te , aild Necrosis, focal, ainiaal -Vascular aineralization, aild Alveolar aacrophages, aultifocal, aild -Acir.ar atrophy, aoderate -Sialadenitis, chronic, aarked The following tissues aere found to be within nornal lia its : Spleen, Heart, Testis/Epididyais, Prostate, Stoaach,. Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Pituitary. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 160 3 2 4 C00712 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Annal Nueber: 1R-3651 Sex: Male Group: ( 1 FC-143 30 ppt Fate: (Keek: 106) Terminal Sacrifice Macroscopic Observations: Kidney Microscopic Observations: Adrenal Esophagus Heart Kidney Liver Lung Pancreas Pituitary -Multiple cysts in one area of right kidney. -Cortical vacuolation, local areas, aild Sinusoidal ectasia, cortex, tild -Not examined, eissing -Myocarditis, chronic nonsuppurative, ainisal -Chronic progressive nephropathy, oderate Pelvic aineralization, iin n a i Cyst, cortical, aultiple -Hepatocyte vacuolation, eultifccal, ai Id Hepatocyte alteration, vacuolated, focal, aild Megalocytosis, ainiaal -Vascular aineralization, aild -Not exasined, aissing -Hyperplasia, focal, pars distalis The following tissues Mere found to be within- noraal lia its : Spleen, Testis/Epicii/ais, Prostate. Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Salivary Gland. Aniaal Nueber: IP-3652 Sex: Male Group: ( 61 FC-143 30 ppa Fate: !Neek= 94) Sacrificed in extreais Macroscopic Observations: Pituitary Stoaach Microscopic Observations: Adrenal Kidney Liver Lung Pituitary Prostate Spleen Stoaach Thyroid Urinary Bladder -Enlarged due to aass, 1.2 ca dia. -Lining appears thickened (eceaatous); possible ulcer in cardia. -Cortical vacuolation, eultifccal, aild -Vacuolation, conv. tub. epitheiua, ainiaal -Portal bile duct proliferation, aild Hepatocyte vacuolation, diffuse, aild -Vascular aineralization, aild Alveolar aacrcphages, aultifocal, aild -Adenoaa -Prostatitis, acute, aarked -Heaosiderosis, aild -Ulcer, aarked -Hyperplasia, C cell, aultifocal, tild -Epithelial hyperplasia, siaple, diffuse, aild Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page: 161 000713 Suaaarized Single Tabulated Aniaal Report (continued) Individual Nacroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-3652 Sex; Male Group: t 1 FC-143 39 ppa Fate: (Neek- 94) SacriFiced in extreais Microscopic Observations (continued): The Following tissues Here Found to be within noraal H alts: Heart, Testis/Epididvais, Parathyroid, Trachea, Esophagus, Salivary Eland, Pancreas. Aniaal Nuaber: 1R-3653 Sex: Hals Group: ! 6) FC-143 39 ppa Fate: (WeeH 106) laminai Sacri Fi ce Macroscopic Obse-vatiors: Testis,'Epididyais Microscopi: Observations: Kidney Lung Testis/Epi di dyais -Right testis saall. -Chronic progressive nephropathy, aild -Vascular aineralization, aild Heaorrhage, local areas, aoderate -Tubule atrophy, aspernatogenesis, unilateral, aarked The Following tissues were Found to be within noraal Halts: Spleen, Liver, Heart, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pituitary, Pancreas. Aniaal Nusbe'! 1R-3654 Sex: Male Group: ( 6) FC-143 39 ppa Fate: (Meefc= 106) Terainal SacriFice Macroscopic Observations: Brain Microscopic Observations: Adrenal Brain Heart Kidney Liver Lung -Dark area, possibly old heaorrhage, in anterior part oF right cerebral heaisphere. -Sinusoidal ectasia, cortex, loderete Pheochroiocytoia, benign, bilateral -Astrocytoaa, benign Large neoplasia occupying auch cF cerebruc. -Myocarditis, chronic nonsuppurative, aultiFocal, aild -Chronic progressive nephropathy, aild Pelvic aineralization, andiate -Hepatccyte alteration, vacuolated, Focal, aild Megalocytasis, ain iia l -Pneuacnia, in te rs titia l, chronic, aultiFocal, aild Alveolar aacrophages, aultiFocal, aild Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 162 326 C00714 Suaaarized Single Tabulated Anita! Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Arnaal Nuaber: 1R-3654 Sex: Male Group: ( 6) FC-143 30 ppi Fate: (Week* 106) Tertina! Sacrifice Microscopi: Observations (continued): Fsncreas - Parathyroid -Acinar atrophy, toderate -Not exatined, not in plane oF section The foilDNing tissues aere Found to be within norta! U nits: Spleen, Testis/Epididyiis, Prostate, Stoaach, Urinary Bladder, Thyroid, Trachea, Esophagus, Salivary Gland, Pituitary. Anna! Nuiber: 1R-3655 Sex: Male 6roup: 6) FC-143 30 ppe Fate: (Neek= 106) Tereinal SacriFice Macroscopic Observations: SoFt Tissues (neck) Testis.'Epididyeis Microscopic Observations: fidr enal Kidney Lung Salivary SI and Testis/Epididyeis -Mass, 4 x 2.5 x 2 ca, salivary gland area. -Right testis enlarged, pale yellowish 1.5 ci dia. less. -Cortical vacuolation, Focal, eild -Chronic progressive nephropathy, aoderate Pelvic aineralization, aild -Vascular aineralization, aild Alveolar aacrophages, local areas, aoderate -Sialadenitis, acute, aarted -Tubule atrophy, asperaatogenesis, unilateral, aoderate Leydig cell adenoaa, unilateral The Following tissues were Found to be within noraal 1is its : Spleen, Liver, Heart, Prostate, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Pituitary, Pancreas. Amasi Nuaber: 1R-3656 Sex: Hale Group: ( 6) FC-143 30 ppa Fate: (Neek= 85) SacriFiced in extreais Macroscopic Observations'. Pituitary Microscopic Observations: Adrenal Kidney Liver Lung -Large aass, 1 x 0.7 ca dia. -Cortical vacuolation, Focal, aild Sinusoidal ectasia, cortex, aild -Chronic progressive nephropathy, ainiaal -Hepatocyte vacuolation, diFFuse, aoderate -Vascular aineralization, aild Heaorrhage, aultifocal, aild Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 163 327 CC0715 Suiiarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuiber: 1R-3656 Sex: Male 6roup: ( 6) FC-143 30 ppi Fate: (Week= 65! Sacrificed in extreiis Microscopic Observations (continued): Parathyroid Pituitary Salivary Gland -Mot exaeined, not in plane of section -Adenoea -Not exaeined, eissing The following tissues were found to be within ncr eal lie its : Spleer., Heart, Testis/Epididysis, Prostate, Stosach, Urinary Bladder, Thyroid, Trachea, Esophagus, Pancreas. Anna! Nuice-: 1R-3657 Sex: Male Group: ( 6) FC-143 30 ppc Pate: (Week: 65) Sacrificed in extreiis Macroscopic Observations: Pituitary Microscopic Observations: Heart Liver Lun; Pancreas Pituitary Salivary Gland -Enlarged, 0.8 ci dia. -Myocarditis, chronic nonsuppurative, focal, oderate -Portal aononudear cell in filtra te , iild -Vascular aineralization, iild Alveolar aacrophages, aultifocal, iild Heeorrhage, local areas, iild -Acinar atrophy, lin iia l -Adenoaa -Not exanined, aissing The following tissues were found to be within noraal lin t s : Spleen, Kidney, Testis/Epididyais, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus. Ari aal Nuaber: 1R-3658 Sex: Male Group: ( 6) FC-143 30 pps Fate: (Week= 106) Terainal Sacrifice Macroscopic Observations: Eye Microscopic Observations: Eye Kidney Liver Lung -Right eye appears cloudy. -Keratitis, chronic, unilateral, iild -Chronic progressive nephropathy, aild -Hepatocyte alteration, vacuolated, aultifocal, aild Regalocytosia, ainiaal -Vascular aineralization, aild Alveolar aacrophages, aultifocal, aild Species: Rat Project Nuiber: 02B1CR0012 328Suiiarized STAR Page: 164 000716 Suaaarized Single Tabulated Anieal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Tt*o Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anieal Nuaber: 1R-365G Sex: Male Group: ( 6) FC-143 30 ppe Fate: (Meek= 106) Terainal Sacrifice Microscopic Observations (continued): Pituitary - Thyroid 'Cyst, pars distalis -Hyperplasia, C cell, focal, eoderate The following tissues were found to be within noreal lie its : Spleen, Heart, Testis/Epididyeis, Prostate, Stoaach, Urinary Bladder, Adrenal, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Anieal Nueber: 1R-3659 Sex: Male Group: ( 6) FC-143 30 ppe Fate: (deefc= 96) Sacrificed in extreeis Macroscopic Observations: Pituitary Liver -Large heaorrhagic aass, 1.4 x 0.8 ce. -Pale and B o ttle d . Adrenal Kidney Liver Lung Parathyroid Pituitary Spleen Testis/Epid idyais -Cortical vacuolation, diffuse, aild Sinusoidal ectasia, cortex, aild -Chronic progressive nephropathy, aild Pelvic mineralization, aarked -Portal aononudear cell in filtra te , aild Portal bile duct proliferation, aild Hepatocyte vacuolation, periportal, aoderate -Vascular aineralization, aild -Not exaained, not in plane of section -Adenoaa -Heaosiderosis, aild -Vascular aine-alization, aild The -following tissues aere found to be within noraal lia its : Heart, Prostate, Stomach, Urinary Eliidder, Thyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Ariaal Nuaber: 1R-3660 Sex: Hale Group: ( 6) FC-143 30 ppi Fate: (Keek1 106) Terair.al Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Heart Kidney Liver -No visible lesions. -Sinusoidal ectasia, cortex, aild -Myocarditis, chronic nonsuppurative, aultifocal, aild -Chronic progressive nephropathy, aild -Portal aononudear cell in filtra te , aild Portal bile duct proliferation, aild Species: Rat Project Nuaber: 02B1CR0012 Suaiarized STAR Page: 165 3 2 9 000717 Suaaanzed Single Tabulated Aniaal Report (continued) Individual Hacroscopic and Microscopic Observations Rike*- Laboratories, Inc. 3H FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-3660 Sex: Male Sroup: ( 6) FC-143 30 ppe Fate: ibieek= 106) Terainal Sacrifice Microscopic Observations (continued): Lung Parathyroid Thyroid - -Vascular aineralization, aild Pneuaonia, in te rs titia l, chronic, focal, aild Alveolar aacrophages, aultifocal, aild -Not exaimed, not in plane of section -C cell adenona, unilateral Ultiaobranchial cyst The following tissues were found to be within noraal U nits: Spleen, Testis/Epididyais, P-ostate, Stoaach, Urinary Bladder, Trachea, Esophagus, Salivary Gland, Pituitary, Pancreas. Aniaal Nuaber: 1R-3661 Sex: Male 6roup: ( 6) FC-143 30 ppa Fate! (Neex= 106) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Heart Kidney Lung Salivary Bland -No visible lesions. -Cortical vacuclation, focal, aild -Myocarditis, chronic nonsuppurative, aultifocal, aild -Chronic progressive nephropathy, aild -Vascular aineralization, aild -Sialadenitis, chronic, ni Id The following tissues were found to be within noraal l i i i t s : Spleen, Liver, Testis/Epididyais, Prostate, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Pituitary, Pancreas. Aniaal Nuaber: 1R-3662 Sex: Male Group: ( 6) FC-143 30 ppa Fate: (Ueek= 94) Sacrificed in extreais Hacroscopic Observations: Eye Lung Spleen Liver Kidney Testis/Epididyais Microscopic Observations: Adrenal -Bilateral opacities -Multiple white lesions, 0.2 ca dia., in le ft lobe. -Slightly enlarged -Hass, 4.5 x 4 x 2 ca, le ft lateral lobe. -Both kidneys pale and enlarged. -Both testes very saall. -Sinusoidal ectasia, cortex, aild Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page: 166 330 000718 Suaaarized Single Tabulated Aniaal Report (continued) Individual Hacroscopic and Hicroscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuiber: 1R-3462 Sex: Hale Group: ( 4) FC-143 30 ppa Fate: (Neek= 94) Sacrificed in extreais Hicroscopic Observations (continued): Eye Heart Kidney Liver Lung Parathyroid Pituitary Testis/Epididyais Thyroid Urinary Bladder - -Cataract, tiia te ra l -Hyocarditis, chronic nonsuppurative, ultifocal, ni Id -Chronic progressive nephropathy, aarkej Pyelitis, acute, aild Cyst, cortical, derate -Portal acnonudear cell in filtra te , aild Portal bile duct proliferation, aild Hepatocyte alteration, vacuolated, focal, aild Hepatocellular carcinoaa Large, poorly differentiated neopiasa. Trabecular and adenoid patterns. -Vascular aineralization, aild Alveolar aacrophages, multifocal, aild Heaorrhage, local areas, aild -Not exaaineb, not in plane of section -Cyst, pars distalis -Tubule atrophy, asperaatogenesis, bilateral, aild -Not exaained, not in plane of section -Epithelial hyperplasia, siaple, diffuse, aild Cystitis, chronic, diffuse, ainiaal The following tissues were found to be within norr.a! 1in its : ' Spleen, Prostate, Stoiach, Trachea, Esophagus, Salivary Gland, Pancreas. Aniaal Nuaber: 1R-3663 Sex: Hale Group: ( 4) FC-143 30 ppa Fate: (Week* I03 Teninal Sacrifice Hacroscopic Observations: Kidney Hicroscopic Observations: Kidney Liver Lung -Cyst, 4 ca dia. -Chronic progressive nephropathy, acderate -Portal aononudear cell in filtra te , aild Portal bile duct proliferation, aild -Vascular aineralization, aild The following tissues were found to be within noraal lia its : Spleen, Heart, Testis/Epididyais,, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Bland, Pituitary, Pancreas. Species: Rat Project Nuaber: 02B1CR002 331Suaaarized STAR Page: 167 000719 Suiiarired Single Tabulated Aniial Report (continued! Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Annal Nuiber: 1R-3664 Sex: Male Group: ( 61 FC-143 30 ppa Fate: (Heek= 106) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Heart Liver Lung -Mo'visible lesions. -Myocarditis, chronic nonsuppurative, ultifocal, aild -Hyperplasia, Kupffer cell, diffuse, aode'ate -Vascular aineralization, aild Heaorrhage, local areas, aild The following tissues were found to be within norrsal lia its : Spleen, Kidney, Testis/Epididvais, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pituitary, Pancreas. Ani sal Nuiber: 1R-3665 Sex: Male Group! ! 6) FC-143 30 ppn Fate! (Week= 40) Sacrificed in extr esis Macroscopic Observations: Li VET Spleen Maaaary Gland Microscopic Observations: Liver Parathyroid Skin Spleen -Slightly pale -Slightly enlarged -Mass with ulcerated heeorrhagic surface, 6.5 x 6 x 4.5 ci, in right axilla. -Necrosis, centrilobular, lild Heiatopoiesis, extraeedullary, wild -Not exaained, not in plane of section -Fibrosar coaa Highly cellular neoplasi with lyiphatic invasion. Surface ulcerated. -Heiatopoiesis, extraiedullary, increased, arked The following tissues were found to be within norial lia its : Kidney, Heart, Lung, Testis/Epididyiis, Prostate, Stoeach, Urinary Bladder, Adrenal, Thyroid, Trachea, Esophagus, Salivary Gland, Pituitary, Pancreas. Aniial Nuiber: 1R-3666 Sex: Male Group: ( 6) FC-143 30 ppe Fate: !Neek= 106) Teriinal Sacrifice Macroscopic Observations: Eye Skin Pituitary -Opacity, right eye. -Hair loss on liib s with scab foriationi possible d e n a titis. -Raised dark lass, 0.B ci dia. Species: Rat Project Nuiber: 02B1CR0012 Suiiarized STAR Page: 168 000720 Suiiarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nuiber*. 1R-3666 Sex: Hale Broup: ( 6 ! FC-143 30 ppi Fate: (Naek= 106) Teriina! Sacrifice Macroscopic Observations (continued): kidney (continued! Microscopic Observations: Adrenal Eye Heart Kidney Live- Lung Pancreas Pituitary Saliva-y Gland Skin Testis-'Epididyiis -Falei possibly soiewhat enlarged. -Sinusoidal ectasia, cortex, loderate -Retinal atrophy, unilateral Cataract, unilateral -Myocardial fibrosis, focal, ai Id -Chronic progressive nephropathy, loderate -Portal ncnonudear cell in filtra te , ci Id Mononuclear cell in filtra tio n , lu ltifo c a l, ild -Vascular lineralization, tiId Hescrrhage, local areas, lild -Polyarteritis, nininal -Adenoia -Sialadenitis, chronic, noderate -Ulcer, larked -Polyarteritis, lild The following tissues were found to be within norial l i i i t s : Spleen, Prostate, Stciach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus. Anisal Nuiber: IP-3667 Sex: Hale Group:! ! 6) FC-143 30 ppi Fate: (Nsek= 106! Teriinal Sacrifice Macroscopic Observations: Microscopic Observations: Heart Kidney Liver Lung Pancreas Pituitary Salivary Gland Thyroid Urinary Bladder -No visible lesions. -Myocarditis, chronic nonsuppurative, ultifccal, lild -Chronic progressive nephropathy, iiId Pyelitis, acute, nild -Portal lononuclear cell in filtra te , iiId Portal bile duct proliferation, iiId -Vascular lineralization, lild -Acinar atrophy, lild -Adenoia -Sialadenitis, chronic, larked -Hyperplasia, C cell, focal, iiId -Nat exaiined, lissing The following tissues were found to be within norial Units*. Spleen, Testis/Epid idyiis, Prostate, Stoiach, Adrenal, Parathyroid, Trachea, Esophagus. Species: Rat Project Nuiber: 0261CR0012 333Suiiarized STAR Page: 169 000721 Suatarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Huaber: IK-3668 Sex: Male Fate: (Keek= 106) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Heart Kidney Liver Lung Pituitary Broup! ( 6) FC-143 30 pps ' -No visible lesions. -Sinusoidal ectasia, cortex, ai 1 d -Myocarditis, chronic nonsuppurative, aultifocal, slid -Chronic progressive nephropathy, ainieal -Portal aononudear cell in filtra te , ai id Necrosis, focal, aild -Vascular aineralization, aild Heacrrhage, aultifocal, aild -Adencna The foilDwing tissues aere found to be within noraal lia its : Spleen, Testis/Epididyais, Prostate, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary SI and, Pancreas. Aniaal Nuaber! 1R-3669 Sex: Hale Sroup: ( 6) FC-143 30 ppa Fate: IHeek= 70) Sacrificed in extreais Macroscopic Observations: Skin Large Intestine Liver Microscopic Observations! Adrenal Esophagus Lung Parathyroid Salivary Bland Skin Thyroid Trachea -Left side of scrotua ulcerated with rectal-scrotal abscess. -Marked iipaction at terainal colon and dilatation of reaaining colon and ileua containing fecal aaterial. -Pale -Hithin noraal lia its One of pair present -Not exasined, aissing -Alveolar aacrophages, aultifocal, aild Heaorrhage, aultifocal, aild -Not exaained, aissing -Not exaained, aissing -Abscess, subcutaneous -Not exaained, aissing -Not exaained, aissing The following tissues ere found to be within noraal lia its : Spleen, Liver, Kidney, Heart, Testis/Epididyais, Prostate, Stonach, Urinary Bladder, Pituitary, Saall Intestine, Large Intestine, Pancreas. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 170 00072 Suiiarized Single Tabulated flniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anieal Nuiber: 1R-3670 Sex: Male Fate: ilieek= 106) Teriinal Sacrifice Macroscopic Observations: Mesentery kidney Microscopic Observations: Kidney Liver Lung Pancreas Pituitary Salivary Bland Testis/Epididyris Broup: ( 6 ) FC-143 30 ppi ' -Hass, 1.3 x 1.07 in area of pancreas. -Enlarged, pale and pitted. -Chronic progressive nephropathy, larked -Portal lononudear cell in filtra te , lild Portal bile duct proliferation, ai Id -Vascular cineralization, lild -Adenocarcinosa Nell differentiated, ductular pattern. Large aaount of fibrous stroaa. Acinar atrophy, lild Polyarteritis, derate -Adenoea -Sialadenitis, chronic, derate -Polyarteritis, derate The following tissues nere found to be within norial l i l i t s : Spleen, Heart, Prostate, Stoeach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Lyiph Node (eesentericl. Aniial Nuiber: 1R-3671 Sex: Male Broup: ( 6) FC-143 30 ppi Fate: (kieek= 106) Teriinal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Esophagus Kidney Liver Lung Pancreas Parathyroid Salivary Bland Testis/Epididyiis Thyroid Trachea -No visible lesions. -Sinusoidal ectasia, cortex, lild -Not exaained, lissing -Chronic progressive nephropathy, arked -Portal lononudear cell in filtra te , lild -Vascular eineralization, lild Perivascular lononudear in filtra te , lild -Acinar atrophy, ai Id -Not exaained, lissing -Not exaained, lissing -Polyarteritis, derate -Not exaained, lissing -Not exaiined, lissing The following tissues were found to be within nomai l i l i t s : Spleen, Heart, Prostate, Stoiach, Urinary Bladder, Pituitary. Species: Rat Project Nuiber: 02B1CR0012 77 c Suiiarized STAR Page: 171 J 0 5 000723 Suaaarized Single Tabulated Aniaal Report (continued! Individual flacroscopic and Microscopic Observations Riter Laboratories, Inc. 3M FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nueber: 1R-3672 Sex: Male Fate: !Week= 106) Terainal Sacrifice Macroscopic Observations: Pituitary Testis/Epididyais Microscopic Qbservatinns: Ki dney Liver Lung Parathyroid Pituitary Testis/Epididyais Thyroid Group: ( 6) FC-143 30 ppa - -Dark a^ea -Left testis snail. -Chronic progressive nephropathy, ainiaal -Portal aononudear cell in filtra te , a:ld Hepatocyte alteration, basophilic, focal, aild -Vascular aineralization, aild -Not exaained, not in plane of section -Adenoaa -Tubule atrophy, asperaatogenesis, unilateral, aarked -Cyst, colloid The following tissues were found to be within noraal lia its : Spleen, Heart, Prostate, Stoaach, Urinary Bladder , Adrenal, Trachea, Esophagus, Salivary Gland, Pancreas. Aniaal Nuaber: 1R-3673 Sex: Hale Group: ( 6! FC-143 30 ppa Fate: (Neek= 106! Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Kidney Liver Lung Pancreas Salivary Gland -No visible lesions. -Chronic progressive nephropathy, aild -Portal aononudear cell in filtra te , aild Hepatocyte alteration, vacuolated, aultifocal, aild Megalocytosis, ainiaal -Vascular aineralization, aild Perivascular aononudear in filtra te , aild -Hyperplasia, acinar cell, nodular, aild -Sialadenitis, chronic, aoderate The following tissues uere found to be within noraal lia its : Spleen, Heart, Testis/Epididyais, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Pituitary. Species: Rat Project Nuaber: 0281CROC12 3 3 6Sueaarized STAR Page: 172 0007 24 BEST COPY AVAIlABLE Suaaarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3d FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: IP-3674 Sex: Male Fate: (Neek* 106) Teriinal Sacrifice Macroscopic Observations: Microscopic Observations: Heart Kidney Liver Lung Parathyroid Group: ( 4) FC-143 30 ppe " -No visible lesions. -Myocardial fibrosis, aultifocal, aild Myocarditis, chronic nonsuppurative, aultifocal, aild -Chronic progressive nephropathy, aild -Portal aononuclear cell in filtra te , aild Cystoid degeneration, focal, aild Hepatocyte alteration, vacuolated, aultifocal, aild -Vascular aineralization, aild -Not exaained, not in plane of section The following tissues were found to be within nornal lia its : Spleen, Testis/Epididyais, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Trachea, Esophagus, Salivary Glar.d, Pituitary, Pancreas. Aniaal Nuaber: 1R-3675 Sex: Male Group: ( 4) FC-143 30 ppa Fate: (Neek= 94) Sacrificed in ex.treais Macroscopic Observations: skin Pituitary Microscopic Observations: Heart Kidney Li ver Lung Pancreas Pituitary Skin Testis/Epididyais -Raised area of thickening, 1.5 ca dia., in neck area; possibly inflaaaation or tuaori. perineal lesion appears to be inflaaaed area of subcutaneous fat. -Slightly enlarged due to heaorrhagic area, 0.4 ca dia. -Myocarditis, chronic nonsuppurative, aild -Chronic progressive nephropathy, aild -Cystoid degeneration, aultifocal, aild -Vascular aineralization, aild Heaorrhage, local areas, aild -Hyperplasia, is le t cell, nodular, aild -Adenoaa -Fibr D5arcoaa, subcutaneous -Vascular aineralization, aild The following tissues were found to be within noraa! lia its : Spleen, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Haiaary Gland. Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page: 173 337 000725 BEST COPY A M llE Suiaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: ! Aniaal Nuaber: 1R-3676 Sex: Male Group: ( 6) FC-143 30 ppa Fate! INeek= 106) Terainal Sacrifice Macroscopic Observations', Soft Tissues (leg! Mesentery Kidney Lyaph Node iaesenteric) Microscopic Observations: Adrenal Ecne Heart Kidney Lung Mesentery Pancreas Pituitary Salivary Si and Spleen Testis/Epididysis - -Swollen right and le ft hind feet. -Vessels thickened -Pale, pitted, enlarged. -Enlarged -Cortical vacuolation, local areas, ai 1c Medullary cell hyperplasia, aultifccal, aiid -A rth ritis, synovitis! joints, aoderate -Myocardial fibrosis, local areas, aild -Chronic progressive nephropathy, earked -Vascular mineralizatior, eild -Polyar te ritis , Barked -Polyarteritis, aoderate -Cyst, pars distalis -Sialadenitis, chronic, aarked -Polyarteritis, aoderate -Tubule atrophy, asperaatogenesis, unilateral, aarked Polyarteritis, aarked The following tissues aere found to be Mithin ncraal lim its: Liver, Prostate, Sto&ach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus. Aniaal Nuaber: 1R-3677 Sex: Male Group: ( 6) FC-143 30 ppa Fate: (Week1 106! Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Esophagus Kidney Liver Lung Parathyroid -No visible lesions. -Not exaained, aissing -Chronic progressive nephropathy, aild -Portal aononuclear cell in filtra te , aild Cystoid degeneration, focal, aild Hepatocyte attention, vacuolated, aultifocal, aild Megalocytosis, ainiaal Necrosis, aultifocal, aild -Vascular ainerali2 ation, aild Pneuaonia, in te rs titia l, chronic, aultifocal, aild -Not exaained, not in plane of section Species: Rat Project Nuaber: 0281CR0I2 338Suaaarized STAR Page: 174 000726 Suttarized Single Tabulated Antal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anita! Nutber: 1R-3677 Sex: Hale Group: ( 6) FC-143 30 ppi Fate: (Keek= 106) Teninal Sacrifice Microscopic Observations (continued): Tesiis/Epididytis -Polyarteritis, tild Leydig cell adenota, unilateral The following tissues were found to be within noraal lia its : Spleen, Heart, Prostate, Stoiach, Urinary Bladder, Adrenal, Thyroid, Trachea, Salivary Gland, Pituitary, Pancreas. finisal Nutber: 1P-367B Sex: Male Group: ( 6) FC-143 30 ppi Fate*. (leek= 6?) Sacrificed in extreiis Macroscopic Observations: Pituitary Liver Microscopic Observations: kidney Liver Lung Pituitary Spleen Stoiach -Hetorrhagic tass, 1 x 0.7 ct dia. -Possibly slightly pale. -Chronic progressive nephropathy, tild -Porta! tononudear cell in filtra te , tild Portal bile duct proliferation, tild Hepatocyte vacuolation, diffuse, toderate -Vascular aineralization, tild Hetorrhage, aultifocal, tild -Adenota -Hetosiderosis, tild -Ulcer, tarked The following tissues were found to be within nortal lin t s : Heart, Testis/Epididysis, Prostate, Urinary Bladoer, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Anital Nutber: 1R-367? Sex: Male Group: l 6) FC-143 30 ppi Fate: (Neek= 106) Ter tinal Sacrifice Macroscopic Observations: Microscopic Observations'. Heart Kidney Lung Pancreas -No visible lesions. -Myocardial fibrosis, tu ltifo c a l, tild -Chronic progressive nephropathy, tild -Vascular tineralization, tild Hetorrhage, local areas, toderate -Hyperplasia, acinar cell, nodular, toderate The following tissues were found to be within nortal l i t i t s : Spleen, Liver, Testis/Epididyiis, Prostate, Stotach, Urinary Bladder, Adrenal, Thyroid, Species: Rat Project Nutber: 0281CR0012 Suttarizad STAR Page: ITS 000727 BEST COPY AVAIIABLE Suaaarized Single Tabulated Armai Repent (conti: j.ed; Individual Hacroscopic and Microscopie. Observations Riler Laboratories, I*.:. 3"! FC-143: To Year Oral Toxi : : t y-D~.ccgEr.i ci t y Study ir Rats Aniaal Nuaoe". jp-3i7; cE, HtiE Fate: !* (.= : It: Ter sira! Sacrific e 6r cup! ( 6) FC-143 (r;k- 2-'-r ic Observations {continued): ' The fc:1}~k. - tissues re feund tc be ithin ne-ral lia it: FiretS.roid, Traches, Esochsgue, Salivary Sia--d, Pituitary, Table: 3 Lecer; 1--350 Se*: Hale Group: ( fc! FC-143 30 ppi sek* I t i) Tersine! Sacrifice roseo?:: Otservations*. E?s Aiders: {interrai 1 Toscopic Otservations: Eye Kidney Live- i -U :-, 2s- J Vaf f i."d Scft Tissues iabdoaer) -Opacity, le ft eye. -Soft fatty tusor, 3 x 3 Mli. attached tc nigh -Cataract, unilateral -Chronic progressive nephropathy, foderate Fyelitis, acute, aild -Portal acnsnudea' cell in filtra te , aild -Vascular ameraiization, aild -Sialadenitis, chronic, aa-xed -Fibrosa "he following tissues *er e found to be within norial lia its : Spleen, Heart, Testis/Epid:dyis, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathy-Gid, Trachea, Esophagus, Pituitary, Pancreas. nias! Nster: 1R-363! Sex: Hale Group: ! fc! FC-143 30 ppa Fate: (seek- 105' Tersinal Sacrifice Hacroscopic Otservations: Skin Pituitary Microscopic Otservations: KidneyLiver Lung Pituitary Prostate Skin -Raised ulcerated inflaaaatory lesions, right and le ft hind footpads. -Saal 1 raised heiorrhagic lesion, C.2 ci dia. -Chronic progressive nephropathy, aild -Porta! aononudear cel! in filtra te , aild -Vascular aineraiization, aild Fneuioria, in te rs titia l, chronic, aultifccal, ild Perivascular aononuclear in filtra te , aild -Adenoaa -Prostatitis, acute, aild -Pododeraatitis, ulcerative, bilateral, hindleg, aarked Species: Rat Project timber: 0281CR0012 Sutiarned STAR ?.j i : 17i 3 4 0 G00728 BEST COPY AVAU ABLE Sutaarized Single Tabulated Anita! Report (continued! Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: T*o Year Ora! Toxicity-Oncogenicity Study in Rats Table: 2 Ar.ital Nutber: 1R-368I Sex: Male Broup: ( 6) FC-143 30 ppi Fate: !eek= 106) Terminal Sacrifice Microscopic Observations (continued): Thyroid -Follicular hyperplasia, cystic, unilateral, arked The following tissues were found to be within noma! lim its: spleen, Heart, Testis/Epididysis, Stoiach, Urinary Bladder, Adrenal, Parathyroid, Trachea, Esophagus, Salivary Bland, Pancreas. Anisal Nutber: 1S-3682 Sex: Male Broup: ( 6) FC-143 30 ppi Fate: (Heek= 106! Tertinal Sacrifice Macroscopic Observations: Liver Microscopic Observations: Adrenal Kidney Liver Lung Testis/Epididytis Thyroid -Mottled -Cortical vacuolation, local areas, tild Nodular hyperplasia, cortex, focal, toderate -Chronic progressive nephropathy, tild Calculus, pelvic -Pcrtal tononuclear cell in filtra te , tild Portal bile duct proliferation, tild Cystoid degeneration, tu ltifo c a l, tild -Vascular mineralization, tild Alveolar tacrophages, local areas, toderate -Leydig cell hyperplasia, tu ltifo c a l, tild -Hyperplasia, C cell, focal, tild Follicular adenota The following tissues were found tc be within noma! lim its: Spleen, Heart, Stoiach, Urinary Bladder, Parathyroid, Prostate, Trachea, Esophagus, Salivary Gland, Pituitary, Pancreas. Animal Nutber: 1R-3663 Sex: Male Broup: ( 6) FC-143 30 ppi Fate: (Neek= 106) Tertinal Sacrifice Macroscopic Observations: Microscopic Observations: Kidney Liver Lung -No visible lesions. -Chronic progressive nephropathy, tild -Hepatocyte alteration, vacuolated, local areas, toderate Vascular tineralization, tild Alveolar tacrophages, tu ltifo c a l, tild Species: Rat Project Nutber: 02B1CR0012 341Suuarized STAR Page: 177 BEST COPY AVAIIABLE Suasarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Kuaber: 1R-3683 Sex: Male Group: ( 6) FC-143 30 ppi Fate: (Ueei= 106! Terainal Sacrifice Microscopic Observations (continued): Parathyroid ' -Not exaiined, not in plane of section The following tissues were found to be within norsal h a lts : Spleen, Heart, Testis/Epididvais, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Trachea, Esophagus, Salivary Bland, Pituita-y, Fancreas. Aniaal Kunber: 1R-36B4 Sex: Male Group: 1 6) FC-143 30 ppe Fate: (seek1 106! Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Heart Kidney Liver Lung Salivary Bland -No visible lesions. -Sinusoidal ectasia, cortex, n ld -Endocarditis, chronic, diffuse, aar ked -Chronic progressive nephropathy, si Id Pelvic sineralization, ai 1d -Portal sononuclear cell in filtra te , sild Portal bile duct proliferation, si Id -Vascular sineralization, sild Alveolar sacrophages, ultifo c a l, sild -Sialadenitis, chronic, soderate The -following tissues were found to be within norial lia its : Spleen, Testis/Epididyais, Prostate, Stosach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Pituitary, Pancreas. Aniaal Nutber: 1R-36S5 Sex: Hale Group: ( 6) FC-143 30 pps Fate: (Week 104! Sacrificed in extreais Macroscopic Observations: Skin Pituitary Microscopic Observations: Kidney Liver Lung Pituitary Prostate Salivary Gland Skin -Raised ulcerated lesion on le ft hind footpad. -Seal 1 dark area. -Chronic progr essive nephropathy, sinisal Pelvic nineralization, sild -Portal sononuclear cel! in filtra te , sild -Vascular sinerahzation, sild -Adenosa -Prostatitis, acute, sild -Not exasined, sissing -Podcderaat: tis , ulcerative, sarked Species: Rat Project Nusber: 0281CR0012 Suasarized STAR Page: 178 34 000730 M M COPY AVAiii Suaaariced Single Tabulated Aniaal Report (continued) iljdividual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3(1 FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuafaer: 1R-3BB5 Sex: dale Group: ( 6) FC-143 30 ppi Fate: (Week* 104) Sacrificed in extreeis Microscopic Observations (continued): Testis/Epididyiis -Tubule atrophy, asperaatcgenesis, unilateral, aarked The fclloaing tissues ere found to be within noraal lia its : Heart, Stcaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Spleen, Pancreas. Aniaal Nuaber: 1R-3A86 Sex: Male 6roup: ( 61 FC-143 30 ppa Fate: (Reek= 106) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Kidney Li ver Pituitary Salivary Gland -No visible lesions. -Chronic progressive nephropathy, aild -Portal aononuclear cell in filtra te , aild Cystcid degeneration, focal, ainiaal Hepatccyte alteration, vacuolated, focal, aild -Cyst, pars interaedia -Nat exaained, aissing Tne following tissues ere found to be within noraal lia its : Spleen, Heart, Lung, Testis'Epitiidyeis, Prostate, Stcaach, Urinary Bladder, Acrenal, Thyroid, Parathyroid, Trachea, Esophagus, Pancreas. Aniaal Nuaber: 1R-36B7 Sex: Male 6rcup: ( 6) FC-143 30 ppi Fate: Reeks 93) Sacrificed in extreais Macroscopic Observations: Thorax (internal) Heart Lung Liver Kidney Testis/Epididyais Mesentery Microscopic Observations: Adrenal Heart -Filled with blood tinged flu id . -Appears enlarged -Possible areas of consolidation. -Mottled and possible congestion. -Pale and pitted. -One testis appears saall. -Nodular aesenteric blood vessels. -Cortical vacuolation, local areas, aarked Sinusoidal ectasia, cortex, aoderate -Myocardial fibrosis, aultifocal, aild Myocarditis, chronic nonsuppurative, aultifocal, aild Species: Rat Project Nuaber: 02B1CR012 Suaiarized STAR Page: 179 343 000731 Summed Single Tabulated Aniaal Report (continued! Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Tonicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber'. 1R-3687 Sex! Male Group: ( 6) FC-143 30 ppa Fate: (Keek* 98) Sacrificed in extreais Microscopic Observations (continued): kidney Liver Lung Mesentery Pancreas Parathyroid Prostate Testis/Epididyais -Chronic progressive nephropathy, narked Pelvic aineralization, aild -Portal aononuclear ceil in filtra te , aild Portal bile duct proliferation, aild Cystoid degeneration, focal, aild Hepatccyte vacuolation, diffuse, aild -Vascular aineralization, aild Alveolar aacrophages, aultifocal, aild Atelectasis, diffuse, acderate Pneueor.ia, in te rs titia l, acute, local areas aoderate -Polyarteritis, narked -Not exaained, aissirg -Not exaained, not in plane of section -Not exaained, aissing -Tubule atrophy, aspercatogenesis, aoderate Polyarteritis, aoderate Leydig cell hyperplasia, focal, aoderate Sranuloaa, speraatic The following tissues were found to be within noraal U nits: Spleen, Stoaach, Urnary Bladder, Thyroid, Trachea, Esophagus, Salivary Bland, Eye. Pituitary. Aniaal Nuaber: 1P-34BS Sex: Male 6roup: ! i) FC-143 30 ppa Fate: (Week1 89) Sacrificed ir, extreais Macroscopic Observations: Pituitary Thyroid Liver kidney Testis/Epididyais Microscopic Observations: Adrenal Kidney Liver Lung Parathyroid Pituitary Spleen -Enlarged due to raised 1 ca dia. cass. -One thyroid appeared slightly enlarged. -Slightly pale -Pale and slightly enlarged. -Appear saall -Sinusoidal ectasia, cortex, aild -Chronic progressive nephropathy, aoderate -Hepatccyte vacuolation, local areas, tild Necrosis, local areas, aoderate -Vascula'- aineralization, aild -Not exaained, not in plane of section -Adenoaa -Heaosiderosis, aild Species: Rat Project Nuaber: 02B1CR0012 Suaaarned STAR Page: 1B0 3 4 4 000732 Suiiarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations BEST COPY AVAU ABLE Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: Aniial Nuiber: 1R-36B8 Sex: Male Broup: ( 6) FC-143 30 ppa Fate: (Keek- 89) Sacrificed in extreeis Microscopic Observations (continued): Testis/Epididyiis Thyroid -Tubule atrophy, asperiatogenesis, bilateral, i Id -Follicular hyperplasia, cystic, unilateral, arked Ultiiobranchial cyst The iallowing tissues were found to be within norial l i i i t s : Heart, Prostate, Stoaach, Urinary Bladder, Trachea, Esophagus, Salivary Bland, Pancreas. Aniial Nusber: 1R-368R Sex: Male Broup: ( 6! FC-143 30 ppi Fate: <Heek= 104) Teriinal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal kidney Liver Lung Parathyroid Pituitary Thyroid -No visible lesions. -Fheochroiocytoaa, benign, unilateral -Chronic progressive nephropathy, iiId -Portal lononuclear cell in filtra te , lild Portal bile duct proliferation, eiId -Vascular lineralization, iiId -Not exaiined, not in plane of section -Not exaiined, eissing -C cell adenoia The following tissues were found to be within norial l i i i t s : Spleen, Heart, Testis/Epididyiis, Prostate, Stoaach, Urinary Bladder, Trachea, Esophagus, Salivary Eland, Pancreas. Anisal Nuiber: 1R-3690 Sex: Male Group: ( 6! FC-143 30 ppi Fate: (Week= 106! Teriinal Sacrifice Macroscopic Observations: Testis/Ep:didyii5 Microscopic Observations: Adrenal Heart Kidney Liver Parathyroid -Left testis soaewhat s ta ll. -Sinusoidal ectasia, cortex, lin iia l -Myocarditis, chronic nonsuppurative, local areas, iiId -Chronic progressive nephropathy, lild -Portal lononuclear cell in filtra te , lild Hegalocytosis, a iniial -Not exaiined, not in plane of section Species: Rat Project Nuiber: Q281CR0012 Suiiarized STAR Page: 181 ^ -r J 4J 000733 Suiiarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tec Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuiber: 1R-3690 Sex: Hale Group: ( 6) FC-143 30 ppi Fate: (Heek= 106) Teriinal Sacrifice Hicroscopic Observations (continued): Pitu:tary Testis/Epididyiis -Cyst, pars intereedia -Tubule atrophy, aspermatogenesis, unilateral, arked Tne follcuir.: tissues re found to be within ncrial lia its : Spleen, Lung, Prostate, Stoaach, Urinary Bladder, Thyroid, Trachea, Esophagus, Salivary Bland, Pancreas. AninaI Nuaber: 1R-391 Sex: Hale 6roup: ( 6i FC-143 30 ppi Fate: Week* 106! Teriinal Sacrifice Macroscopic Observations: Hatiary Si and Hicroscopic Observations: Heart Kidney Liver Lung Pancreas Parathyroid Skir, -Subcutaneous, aultiiobular lass, 5.5 x 4 x 5 , left. -Myocardial fibrosis, local areas, liId Myocarditis, chronic nonsuppurative, aultifocal, lild -Chronic progressive nephropathy, lild Pelvic lineralization, lild -Portal lononudear cell in filtra te , lild -Vascular lineralization, lild -Acinar atrophy, lin iia l -Net exaeined, not in plane of section -Fibrosarcoia, subcutaneous The fo il owing tissues were found to be within noreal lia its : Testis/Epidiesya:s, Prostate, Stciach, Urinary Bladder, Adrenal, Thyroid, Trachea, Esophagus, Salivary Gland, Pituitary, Spleen. Aninal Nuiber: 1R-3692 Sex: Hale Group: I 6) FC-143 30 ppi Fate: (Week: 106) Teriinal Sacrifice Macroscopic Observations: Hicroscopic Observations: Kidney Liver Lung Pituitary -No visible lesions. -Chronic progressive nephropathy, ai Id -Portal lononudear cell in filtra te , lild -Vascular lineralization, iiId -Adenoea The following tissues ere found to be within norial lia its : Spleen, Heart, Testis/Epididyais, Prostate, Stoaach, Urinary Bladder, Adrenal, Thyroid, Species: Rat Project Nuiber: 0261CR0012 346Sunarized STAR Page: 182 000734 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3(1 FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nueber: 1R-3692 Sex: Male Group: ( 1 FC-143 30 ppa Fate: iileek= 106) Terainal Sacr ifice Microscopic Observations (continued): The following tissues were Found to be within noreal h a its (continued): Parathyroid, Trachea, Esophagus, Salivary Bland, Pancreas. Aniaal Nusbsr: 1R-3693 Sex! Male Group: ( 6) FC-143 30 ppa Fate! <Week= 106) Terainal Sacrifice Macroscopic Observations: Skin Liver Microscopic Observations! Adrenal Hea-t Ki dney Liver ?t ^ n n Pancreas Salivary Gland Skin -Raised ulcerated inflaaaed le sicn, right hind footpad. -Appears aottled -Cortical degeneration, focal, aoderate Phecchroaocytcaa, benign, bilateral -Myocarditis, chronic nonsuppurative, aultifocal, aild -Chronic progressive nephropathy, aoderate Pelvic aineralization, aoderate -Portal aononudear cell in filtra te , aild Portal bile duct proliferation, aild Cystoid degeneration, aultifocal, aild Hepatocyte alteration, vacuolated, focal, aild -Vascular aineralization, aild Alveolar aacrophages, aultifocal, aild Heacrrhage-, aultifocal, aild -Acinar atrophy, aild -Sialacenitis, chronic, aoderate -Pododeraatitis, ulcerative, aarked The following tissues were found to be within noraal lia its : Spleen, Testis/Epididyais, Prostate, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Pituitary. Aniaal Nueber: 1R-3694 Sex: Male Group! ( 6! FC-143 30 ppa Fate: (Keek* 106) Tereina! Sacrifice Macroscopic Observations: Pituitary Hicroscopic Observations: Adrenal Kidney -Reddish aass, 0.5 ca dia. -Pheochroaocytoaa, benign, unilateral -Chronic progressive nephropathy, aild Species: Rat Project Nueber: 2B1CR0C12 Sumrized STAR Page: 1B3 3 4 1 000735 Suiaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riter Laboratories, Inc. 3M FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-3694 Sex: Hale Sroup: ( 6) FC-143 30 ppa Fate: (Keek- 106) Terainal Sacrifice Microscopic Observations (continued): Liver Lung Pancreas Pituitary -Portal aononudear cell in filtra te , aild Portal bile duct proliferation, aild -Alveolar aacrophages, aild -Hyperplasia, isle t cell, nodular, aild -Adenota The fol 1Dating tissues were found tc be within noraal lia its : Spleen, Heart, Testis/Epididye:s, Prostate, Stowach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Bland. Aniaal Nueber: 1R-3695 Sex: Male Group: ( 6) FC-143 30 ppa Fate: (Week= 106) Tereinal Sacrifice Macroscopic Observations: Hicroscppic Observations: Adrenal Esophagus Heart Liver Lung Pituitary -No visible lesions. -Medullary cell hyperplasia, focal, aild * One of pair present -Not exaained, aissing -Myocarditis, chronic nonsuppurative, aultifocal, aild -Portal aononudear cell in filtra te , aild -Vascular aineralization, aild Pneuaonia, in te rs titia l, chronic, focal, aild -Not exaained, aissing The following tissues were found to be within noraal lia its : Spleen, Kidney, Testis/Epididyais, Prostate, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Salivary Eland, Pancreas. Aniaal Nuaber: lfi-4706 Sex: Feaale Group! ( 6) FC-143 30 ppa Fate: Reek1 72) Sacrificed in extreais Macroscopic Observations: Maaaary Gland Microscopic Observations: Adrenal Kidney Liver Lung -Large ulcerated aass, 1.5 x 3.5 ca dia. in le ft inguinal area -Sinusoidal ectasia, cortex, air.iaal -Chronic progressive nephropathy, ainiaal -Heaatopoiesis, extraaedullary, aild -Vascular aineralization, ainiaal Species: Rat Project Nuaber: 0281CROO12 348Suaaarized STAR Page: 184 C00736 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Rifcer Laho'atories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nueber: 1R-470 Sex: Feiale 6roup: ( i) FC-143 30 ppi Fate: (Keek* 72) Sacrificed in extreais Microscopic Observations (continued): Maneary Sland Pancreas Parathyroid Pituitary Spleen -Adenocarcinoia -Acinar atrophy, ainiaal -Not exaainec, not in plane of section -Aderoaa -Heaatcpoiesis, extraeedullary, increased, arked The following tissues were found to be within noreal lia its : Heart, Uterus, Ovary, Stoeach, Urinary Bladder, Thyroid, Trachea, Esophagus, Salivary Stand. Aniaal Nueber: 1R-477 Sex: Feaale Group: ( 6) FC-143 30 ppi Fate! (Neek= 90) Found Dead Macroscopic Observations: Haiaary Sland Pituitary Microscopic Observations: Adrenal kidney Maaaary Gland Ovary Parathyroid Pituitary -Large cystic aass, 8 x 4.5 x 2.S ca, fille d with blood, in perineal and right inguinal areas. -Heaorrhagic lesion, 1.5 x 1 ca. -Sinusoidal ectasia, cortex, aild -Chronic progressive nephropathy, aild -Adenocarcinoaa -Hithin noraal lia its One of pair present -Not exaained, not in plane of section -Adencaa The fcilowirg tissues were found to be within ncreal lia its : Spleen, Liver, Heart, Lung, Uterus, Stoeach, Urinary Bladder, Thyroid, Trachea, Esophagus, Salivary Eland, Pancreas. Animal NuebEr: 1R-4708 Sex: Feaale Group: ( 6) FC-143 30 ppe Fate: (Neek= 105) Terainal Sacrifice Macroscopic Observations: Pituitary Maaaary Gland Microscopic Observations: Adrenal -Raised aass, 0.5 ca dia. -Snail nodular aass, 1 ca dia., in le ft axilla; large aass, 5 x 5 x 3 ca, in right inguinal area. -Sinusoidal ectasia, cortex, noderate Species: Rat Project Nueber: 0281CR0012 Suaaarized STAR Page: 1B5 000737 Sutaarized Single Tabulated Aniaal Report (continued) Individual Hacroscopic and Hicroscopic Observations Riker Laboratories, Inc. 3H FC-143: T*o Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4708 Sex: Feaale Group: ( G) FC-143 30 ppa Fate: (Week* 105! Tereina! Sacrifice Hicroscopic Observations (continued): Haasary Eland Parathyroid Pituitary Uterus -Fibroadenoaa -Not exaained, not in plane of section -Adenoea -Cystic glands, eoderate The following tissues were found to be within noraal lia its : Spleen, Liver, Kidney, Heart, Lung, Ovary, Stoaach, Urinary Bladder, Thyroid, Trachea, Esophagus, Salivary Si and, Pancreas. Aniaal Nuaber: 1R-4709 Sex: Feaale Group'. ( 6) FC-143 30 pps Fate: (Heek= 99) Sacrificed in extreai s Hacroscopic Observations: Pituitary Abdoeen (internal) Liver Hicroscopic Observations'. Adrenal Kidney Liver Lung Kaaaary Gland Pancreas Parathyroid Pituitary Spleen -Enlarged, 0.7 ca dia. -Gastrointestinal tract distended with gas. -Yellowish focal lesion, 0.9 x 0.3 ca, in fissure of aedian lobe; liver possibly slightly pale. -Sinusoidal ectasia, cortex, aarked -Pelvic aineralization, aild -Portal aononudear cell in filtra te , aild Hepatocyte alteration, vacuolated, focal, aarked -Vascular aineralization, aild -Galactocele -Not exaained, aissing -Not exaained, not in plane of section -Adenoea -Heaatopoiesis, extraaedullary, increased, aild The fcllowing tissues ere found to be within nornal lia its : Heart, Uterus, Ovary, Stoaach, Urinary Bladder, Thyroid, Trachea, Esophagus, Salivary Gland. species: Rat Project Nuaber: 02B1CR0012 Suaaarjzed STAR Page: 18G 000738 Suaiarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4710 Sex: Feaale Group: ( 6) FC-143 30 ppa Fate: (Neek= 103) Terainal Sacrifice Macroscopic Cbse-vations: Pituitary Macnary Eland Microscopic Observations: Adrenal Lung Maaaar y Eland Ovary Parathyroid Pituitary Uterus - -Heacrrhagic aass, 0.6 ca dia. -Large aultilobular aass, 9 x 7.5 x 3 ca, in le ft inguinal area. -Sinusoidal ectasia, cortex, aarked Cortical degeneration, aoderate -Vascular aineralization, aild -Fibroadenoaa Extensive necrosis of tuaor. -Cyst -Not exaained, not in plane of section -Adenoaa -Cystic glands, aarked Leioayona The -following tissues ere found to be within ncrr.al lin t s : Spleen, Liver, Kidney, Heart, Stoaach, Urinary Bladder, Trachea, Esophagus, Salivary Eland, Pancreas, Thyroid. Aniaal Nusber: 1R-4711 Sex: Feaale Group: ! 6) FC-143 30 ppa Fate: iWeek- 105! Tereinal Sacrifice Macroscopic Observations: Manaary Gland Microscopic Observations: Adrenal Kidney Liver Lung Maaaary Eland Pituitary 5pleen -Large aass, 10 x 10 x 4 ca, in right inguinal/perineal area. -Cortical vacuolation, local areas, aild -Chronic progressive nephropathy, aild Pelvic aineralization, aild -Hepatocyte vacuolation, aultifocal, aild -Vascular aineralization, ainiaal -Fibroadenoaa -Adenoaa -Ueaatopoiesis, extraaedullary, increased, aoderate The following tissues ere found to be within norral lia its : Heart, Uterus, Ovary, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page: 187 3 5 000739 Summarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4712 Sex: Feiale Group: < 6) FC-143 30 ppa Fate: (Heek= 94) Sacrificed in extreeis Macroscopic Observations: Pituitary Mammary Bland Pancreas Microscopic Observations: Adrenal Heart Kidney Liver Lung Mammary Gland Ovary Pancreas Pituitary Uterus - -Hemorrhagic aass, 1.3 x 1 cm. -Cystic aultilcbular mass, 5 x 5 x 3 cm, le ft inguinal area, fille d with dark flu id ; saall cystic aass, 2 x 1 cb, in inguinal area. -Saall nodule, 0.3 ca dia. -Sinusoidal ectasia, cortex, aoderate -Myocarditis, chronic nonsuppurative, aultifocal, aild -Chronic progressive nephropathy, ainiaal Pelvic aineralization, ainiaal -Portal aononudear cell in filtra te , aild Portal bile duct proliferation, aild -Vascular aineralization, aild Alveolar aacrophages, aultifocal, aild -Balactocele Adenocarcinoma -Cyst -Is le t cell adenoma -Adenoma -Cystic glands, aoderate The following tissues nere Found to be within norial l i i i t s : Spleen, Stomach, Urinary Bladder, Thyroid, Parathyroid, Tracha, Esophagus, Salivary Bland. Animal Nuaber: 1R-4713 Sex: Female Group: ( 6) FC-143 30 ppa Fate: (Ueek= 97) Found Dead Macroscopic Observations: Liver Uterus Microscopic Observations: Liver Lung Lyaph Node Haaaary Bland -Slightly pale -Lett uterine horn has saall dear spherical aass, 0.5 ci dia.i right uterine .horn greatly enlarged and fille d with dark bloody flu id . -Portal aononudear cell in filtra te , aild Necrosis, aultifocal, aild -Vascular mineralization, aild -Hyperplasia, reactive, toderate -Not exaained, aissing Species: Rat Project Nuaber: 0281CR0012 Summarized STAR Page: 18B 000740 SuaaarizEd Single Tabulated flniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Am ai Nuaber*. 1R-4713 Sex: Feaale Group: ( b) FC-143 30 ppa Fate: (Keek^ 97) Found Dead Microscopic Observations (continued): Pituitary Spleen Uterus -Adenoaa * -Hesatopoiesis, extraaedullary, mild -Cystic glands, aarked Hesangiosa increased, The following tissues were found to be within nortal lia its : Kidney, Heart, Ovary, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas. finina! Nusber: 1R-4714 Sex: Feaale Group: ( 6) FC-143 30 ppa Fate: (Neek= 105) Terainal Sacrifice Macroscopic Observations: Maaaary Gland Lyaph Node (abdoainal) Microscopic Observations: Adrenal Heart Kidney Liver Lung Maaaary Bland Pancreas Spleen Uterus -Milk cyst, le ft axilla large nass, 6.5 x 7 x 4 ca, in le ft inguinal area. -Renal lyaph nodes enlarged. -Sinusoidal ectasia, cortex, aoderate Adenoaa, cortical Tuaor described as enlarged renal lyaph node at necropsy. -Myocarditis, chronic nonsuppurative, aultifocal., aild -Chronic progressive nephropathy, aild -Negalocytosis, ainiaa! -Vascular aineralization, aild -FibroadEnoaa Salatocele Adenocarcincaa -Not exaained, Hissing -Hesatopoiesis, extraaedullary, increased, aild -Polyp The following tissues were found to be within ncraal U nits: Ovary, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pituitary. Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Pie:0^74.153 Sueaarized Single Tabulated Aniial Report (continued! Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4715 Sex: Feaale Group: ( 6) FC-143 30 ppa Fate: (Neek= 105) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Heart Kidney Liver Lung Ovary Pancreas Parathyroid Pituitary Spleer ' -No visible lesions. -Sinusoidal ectasia, cortex, unilateral, narked -Myocarditis, chronic nonsuppurative, aultifocal, aild -Pelvic aineralizatisn, Moderate Polyarteritis, ainiaal -Hepatocyte vacuslatior., aultifocal, ainiaal -Vascular aineralization, aild -Cyst, unilateral -Polyarteritis, ainiaal -Net exaained, not in plane of section -Adenoaa -Heaosiderosis, aild The fdloning tissues Mere found to be within noraal lia its : Uterus, Maaiary Gland, Stcaach, Urinary Bladder , Thyroid, Trachea, Esophagus, Salivary Gland. Aniaal Nuaber: 1R-4716 Sex: Feaale Broup: ( 61 FC-143 30 ppa Fate: (Neek= 105) Terainal Sacrifice Macroscopic Observations: Skin Microscopic Observations: Adrenal Lung Ovary Pituitary -Hair thinning on head. -Sinusoidal ectasia, co'tex, narked Cortical degeneration, focal, aild -Vascular aineralization, ainiaal -Cyst, unilateral -Cyst, pars interaedia The fallowing tissues Mere found to be within noraal lia its : Spleen, Liver, Kidney, Heart, Uterus, Maaaary Gland, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas, Skin. Species: Rat Project Nuaber: 0281CR0012 Sueaarized STAR Page: 190 0007^ Suasarized Single Titillated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: IR-4717 Sex: Feeale Broup: ( 6) FC-143 30 ppi Fate: (Week= 105) Tersina! Sacrifice Macroscopic Observations: Pituitary Masaary Gland Adrenal Microscopic Observations: Adrenal Kidney Liver Lung Maaaary Gland Pituitary Uterus -Hsorrhagic aass, 1 ci dia. -Lobular aass, 4 x 3 x 2.5 ct, in le ft axilla! cystic lobular aass, 2.5 x 2 x 1.2 ca, in perineal area. -Left adrenal enlarged. -Sinusoidal ectasia, cortex, aarked Enlargeaent of le ft adrenal due to aassive sinusoidal ectasia. -Chronic progressive nephropathy, ni ni sal Pelvic sineralization, aoderate -Hepatocyte vacuolation, aultifocal, ai Id -Vascular sineralization, cild Alveolar aacrophages, aultifocal, sild Hesorrhage, local areas, aoderate -Fibroadenosa Balactocele Adenocarcinosa -Adenoaa -Cystic glands, aild The -following tissues sere found to be within noraal lia its : Spleen, Heart, Ovary, Stench, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary 61and, Pancreas. Aniaal Nuaber: 1R-471B Sex: Fesale 6roup: ! i) FC-143 30 pps Fate! ieek= 94) Sacrificed in extreais Macroscopic Observations: Pituitary Masra'-y Bland Adrenal Kidney Microscopic Observations: Adrenal Esophagus Kidney Lung -Raised aass, 1.3 ci dia. -Cystic aass, 4 x 3 cs, le ft axilla! silk cyst in the perineal area. -Right adrenal enlarged. -Possibly pale -Sinusoidal ectasia, cortex, aarked Enlargeaent of right adrenal due to aassive sinusoidal ectasia. -Not exaained, aissing -Chronic progressive nephropathy, siniaal -Hesorrhage, local areas, aild Pneuacnia, foreign body, local areas, aarked Species: Rat Project Nusber: 02B1CR0012 Susaa n zed STAR Page: 191 3 5 5 00743 Suaaarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4718 Sex: Feiale Group: ( 6! FC-143 30 ppa Fate: (Week= 94) Sacrificed in extreais Microscopic Observations (continued): Haiaar y Gland Parathyroid Pituitary Uterus -Fibroadenoaa Galactocele -Not exaained, not in plane of section -Adencaa -Cystic glands, aoderate The follouing tissues were found to be within noraal lia its : Spleen, Liver, Heart, Ovary, Stoaach, Urinary Bladder, Thyroid, Trachea, Salivary Gland, Pancreas. Aniaal Nuaber: IR-4719 Sex: Feaale Group: ( 6) FC-143 30 ppa Fate: !Week= 96) Sacrificed in extreais Macroscopic Observations: Eye Pituitary Soft Tissues (neck) Liver Kidney Microscopic Observations: Adrenal Eye Kidney Liver Lung Maaaary Gland Ovary Parathyroid Pituitary Salivary 61and Spleen -Left eye dark, possible heaorrhage. -Sr,all heaorrhagic lesion. -Irregular cystic subcutaneous aass, 6 x 4 x 2 ca, in neck area, possibly aaaaary gland or salivary gland. -Slightly pale -Slightly pale and pitted. -Cortical vacuolation, local areas, aoderate -Keratitis, acute, unilateral, narked -Chronic progressive nephropathy, aild -Hepatocyte vacuolation, diffuse, aild Hepatocyte alteration, basophilic, focal, aild -Heaorrhage, local areas, Barked Metastatic neoplasa -Adenocarcinoaa -Cyst, unilateral -Not exaained, not in plane of section -Adenoaa -Not exaained, aissing -Heacsiderosis, aoderate The following tissues aere found to be within noraal lia its : Heart, Uterus, Stoaach, Urinary Bladder, Thyroid, Trachea, Esophagus, Pancreas. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 192 356 000744 Sueaarized Single Tabulated Annal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tmq Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 flnieal Nuaber: 1R-4720 Sex: Feaale 6roup: ( 6) FC-143 30 pps Fate: !Neek= 105) Terminal Sacrifice Macroscopic Dbservations: Maaeary Bland Microscopic Observations: Adrenal Kidney Liver Lung Maaeary Bland Pancreas Pituitary -Mass in right inguinal area appears to be i nflasted ai Ik cyst. -Sinusoidal ectasia, cortex, aarked -Pelvic ainerali: at ion, eiId -Hepatocyte vacuolation, eultifccal, ai Id Hepatocyte alteration, vacuolated, Focal, ni Id -Alveolar aacrophages, aultifocal, aild Perivascular aononudear in filtra te , aild -Adenocarcinoaa -Acinar atrophy, eoderate -Adenona The following tissues Mere found to be within noria! lis its : Spleen, Heart, Uterus, Ovary, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea Esophagus, Salivary 61and. Aniaal Nusber: 1R-4721 Sex: Feaale Group: ( 61 FC-143 30 ppa Fate: (heek= 95) Found Dead Macroscopic Observations: Maiiary Gland Uterus Microscopic Observations: Adrenal Liver Maaeary Gland Ovary Pancreas Parathyroid Pituitary Salivary Gland Spleen -Mass, 6 x 7.5 x 3.5 ca, aultilcbular, right inguinal area; aultilcbular Bass in le ft inguinal area. -Heaorrhagic lesion, 0.7 x 1 ca, le ft uterine horn. -Sinusoidal ectasia, cortex, aoderate Heaatapoiesis, extraeedullary, cortical, aarked -Keaatopoiesis, extraeedullary, ainiaal -Fibroadenoaa Aderocarcinoea -Within noreal lie its One of pair present -Not exaained, aissing -Not exaained, not in plane of section -Not exaained, aissing -Not exaained, aissing -Heaatopoiesis, extraeedullary, increased, aarked Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 193 357 000745 Suuarized Single Tabulated Aniial Repo-t (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year 0-al Toxicity-Oncogenicity Study in Rats Table: 2 Annal Nuiber: 1R-4721 Sex: Feiale Group: ( 6) FC-143 30 ppi Fate: (Neek= 95) Found Dead Microscopic Observations (continued): Steiach Uterus -Heccrrhage, focal, lucosal, iiId -Polyp The following tissues were found to be within noria! lie its : Kidney, Heart, Lung, Urinary Bladder, 1'hyreid, Trachea, Esophagus. Anna! Nusber: IR-4722 Sex: Feiale Group: ( 6) FC-143 30 ppi Fate: !KeEk- 33) Found Dead Macroscopic Observations: Hassary Gland Liver Pituitary Microscopic Observations: Adrenal Liver Lung Masnar y Gland Pituitary Salivary Gland Skin Spleen Uterus -Large necrotic lass, 11 x B x 3.3 ci, le ft axillary region. -Pale -Heiorrhagic lass, 0.5 ci dia. -Sinusoidal ectasia, cortex, eoderate -Necrosis, eultifocal, larked -Vascular liberalization, lin n a l Alveola'' eacrophages, eultifocal, i i Id -Not exaiined, lissing -Adenoia -Not exaiined, lissing -Fibroia -Heiatopoiesis, extraiedullary, increased, oderate -Cystic glands, larked The following tissues were found to be within norial l i i i t s : Kidney, Heart, Ovary, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Pancreas. Aniial Nuiber: 1R-4723 Sex! Feiale Group: ( 6) FC-143 30 ppi Fate: <lieek= 105) Teriinal Sacrifice Macroscopic Observations: Haiiary Gland Microscopic Observations: Adrenal Kidney -Perineal lass appears to be inflaned silk cyst; large lass, 9 x 5 x 2 ci, in throat area. -Sinusoidal ectasia, cortex, aoderate -Nephrosis, tubular, aoderate Species: Rat Project Nuiber: 02B1CR0012 358Suuarized 5TAR Page: 194 000746 BlSUOPHVMUBLt Suaaarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tmo Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nuaber: 1R-4723 Sex: Feiale Broup: ( 6) FC-143 3C ppi Fate: (Week1 105? Teriinal Sacrifice Microscopic Observations (continued): Lung Maasary Bland Ovary Pituitary Uterus -Vascular aineralization, ainiaal -Adenocarcinoaa, papillary -Tubular hyperplasia, aoderate -Adenoaa -Cystic glands, aarked Hyperplasia, endoeetrial, papillary, aoderatE The folloiing tissues Mere found to be Mithin noraal liaits: Spleen, Liver, Heart, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary 61and, Pancreas. tl Nuaber: 1R-4724 Sex: Feiale Group: ( f>) FC-143 30 ppi (Week= 105; Teraina! Sacrifice Macroscopic 0bser vati cos: Saall Intestine Microscopic Observati DfiSl Adrenal Kidney Liver Lung Lyaph Node Haatary 61and Ovary Parathyroid Saall Intestine Urinary Bladder -Ulcerated outpouching fille d with ingesta in * jejunua. -Sinusoidal ectasia, cortex, aild Cortical degeneration, focal, aild -Chronic progressive nephropathy, ainiaal Pelvic aineralization, ainiaal -Portal aononudear cell in filtra te , aild Portal bile duct proliferation, aild -Vascular aineralization, ainiaal -Hyperplasia, reactive, aoderate -Not exaained, aissing -Tubular hyperplasia, bilateral, aild -Not exaained, not in plane of section -Leioayosarcoaa, jejunua Large in filtra tiv e tuaor with aucosal surface ulcerated. -Not exaained, aissing The fo llo ttin g tissu e s Mere found to be M ith in noraal l i a i t s : Spleen, Heart, Uterus, Stoaach, Thyroid, Trachea, Esophagus, Salivary Gland, Pancreas, Pituitary. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 195 3 5 9 COO747 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-14J: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4725 Sex: Feaale Group: ( 6) FC-143 30 ppa Fate: (Heek= 94! Sacrificed in extreais Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Kidney Lung Pituitary -Raised red sass, 1 ca dia. -Sinusoidal ectasia, cortex, ciId -Chronic progressive nephropathy, c i1d Pelvic aineralization, ainiaal -Vascular aineralization, aild Heaorrhage, aultifocal, aild -Adenoaa The following tissues ere ^ound to be within noraal lia its : Spleen, Liver, Heart, Ovary, Kaasary Gland, Stoaach, Urinary Bladder, Uterus, Thyroid, Farathyroid, T-achea, Esophagus, Salivary Bland , Pancreas. Aniaal Nucber: 1R-4726 Sex: Feaale Group: ( 6) FC-143 30 ppa Fate: (Meek1 105) Terainal Sacrifice Hacroscopic Observations: Pituitary Haaaary 61and Microscopic Observations: Adrenal Kidney Liver Lung Parathyroid Pituitary Urinary Bladder -Heaorrhagic aass, 0.6 ca dia. -Snail aass, appears to be ailk cyst, in throat area. -Sinusoidal ectasia, cortex, aoderate Nodular hyperplasia, cortex, aode-ate -Chronic progressive nephropathy, ainiaalPelvic aineralization, ainiaal -Portal aononudear cell in filtra te , ainiaal -Vascular aineralization, ainiaal Heaorrhage, local areas, aoderate -Not exaained, not in plane of section -Adenoaa -Not exaained, aissing The following tissues were found to be within noraal lia its : Spleen, Heart, Uterus, Ovary, Maatary Gland, Stoaach, Thyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Species: Rat Project Nutber: 0281CR0012 Suaaarized STAR Page: 196 360 000748 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4727 Sex: Feaale Broup: ( b) FC-143 30 ppa Fate: (Week* 105) Terainal Sacrifice Macroscopic Observations: Skin Pituitary Maaaary Bland Micrcscopic Obse'vations: Adrenal Kidney Lung Maaaary Bland Ovary Pancreas Pituitary Uterus ' -Hair loss on head and neck. -Raised dark aass, 0.5 ca dia. -Hass, 4 x 3 ca, right axillary and throat areas! aass, 3 ca dia., le ft side. -Sinusoidal ectasia, cortex, aarked -Pelvic aineralizaticn, ainiaal -Vascular aineralizaticn, aild Heacrrhage, diffuse, aarked -Fibroadenoaa -Cyst -Acinar atrophy, ainiaal -Adenoea -Cystic glands, aarked The fdlouing tissues ere found to be within nc-tal lim its: Spleen, Liver, Heart, Stosach, U-inary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Bland, Eye. Aniaal Nunber: 1R-4728 Sex: Feaale Group: ( 6) FC-143 30 ppa "ate: (Week= 84) Sacrificed in extreais Macroscopic Observations: Abdoaen (internal) Microscopic Observations: Adrenal Kidney Liver Lung Mesentery Pancreas Pituitary Spleen -Abdominal cavitv fille d with bloody fluid; aesentary and oaentua extensively involved with nodular, granular tissue, possibly tuacr or chronic inf 1 aaaation. -Sinusoids! ectasia, cortex, aild Cortical degeneration, focal, aild Metastatic neoplasa -Chronic progressive nephropathy, aild Pelvic aineralizaticn, aild Metastatic neoplasa -Hepatccyte validation, aultifocal, ainiaal Heaatopoiesis, extraaedullary, ainiaal -Vascular aineralizaticn, aild -Hesotheliona, aalignant -Metastatic neoplasa -Adenoaa -Metastatic neoplasa Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page! 197 361 C00749 Summarized Single Tabulated Animal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nuiber: 1R-4728 Sex: Fesale Group: ( 6) FC-143 30 ppa Fate: (Meeks 04) Sacrificed in extremes Microscopic Observations (continued): Stonach Urinary Bladder Uterus -Ulcer Metastatic neoplasm -Metastatic neoplasa -Cystic glands, lild The following tissues were found to be within noreal lie its : Heart, Ovary, Maaaary Gland, Thyroid, Parathyroid, Trachea, Esophagus, Salivary aland. Aniaal Nueber: 1R-4729 Sex! Fetale Group: ( i) FC-143 30 ppa Fate: (Meek= 105> Terminal Sacrifice Macroscopic Observations: Pituitary Hanary Gland Microscopic Observations: Adrenal Kidney Liver Lung Maaaary Gland Parathyroid Pituitary -S iali raised dark aass, 1 ca dia. -Multilobular aass, 3.5 x 3 ca, in right axilla; large aulti 1 obular aass, 9 x 6 x 3 ca, in throat area. -Sinusoidal ectasia, cortex, aoderate Cortical degeneration, local areas, aoderate -Pelvic aineralization, ainiaal -Portal aononudear cell in filtra te , ainiaal Hepatocyte vacuolation, aultifocal, ainiaal -Vascular aineralization, wild Pneuaonia, in te rs titia l, chronic, local areas, aild Heaorrhage, aultifocal, ainiaal 6ranuloda, aultifocal, aild -Fibroadenoma Fibroadenoaa -Not exaained, not in plane of section -Adenoaa The following tissues were found to be within noraal b a its : Spleen, Heart, Uterus, Ovary, Stomach, Urinary Bladder, Thyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Species: Rat Project Number: 0281CR0012 Summarized STAR Page: 198 362 000750 Suuarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nuaber: 1R-4730 Sex: Feiale Broup: ( 6' FC-143 30 dpi Fate: (Ueek= 74) Found Dead Macroscopic Observations! Maaiary Bland Adrenal Microscopic Observations: Adrenal Kidney Liver Lung Manary Bland Pituitary Spleen Uterus -Multilobular ulcerated subcutaneous lass, 4 x 3 x 2.5 ci, right a xilla: cystic aiiary gland, 1 . 2 ci dia ., tille d with ailky white Fluid, in le ft inguinal area. -Right adrenal enlarged. -Sinusoidal ectasia, cortex, larked Cortical degeneration, local areas, loderate -Chronic progressive nephropathy, liId Mineralization, in te rs ititia l, cortical, oderate -Portal lononudear cell in filtra te , ci Id Necrosis, Sultifc c a l, tile -Vascular lineralization, lin ita l -Adenocarcinoia Sslactocele -Adenona -Heiatopoiesis, extraiedullary, increased, ci Id -Polyp The following tissues were found to be within norial l i i i t s : Hsart. Ovary, Stoiach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esoohagus, Salivary Gland, Pancreas. Aniial Nutter: 1R-4731 Sex: Feiale Group: ( 61 FC-143 30 ppi Fate: (Reek* 99! Sacrificed in extreiis Macroscopic Observations: Mauary Bland Liver Stall Intestine Microscopic Observations: Adrenal Kidney Liver Lung -Circular lass, 3 ci dia., in right axilla. -Pale and slightly enlarged. -Area of ulceration with adhesions. -Cortical vacuolation, diffuse, loderate Heiosiderosis, diffuse, cortical, lild -Protein resorption droplets, larked -Hepatocyte vacuolation, diffuse, larked Malignant lyiphoia, histiocytic -Malignant lyiphoia, histiocytic Atelectasis, local areas, ciId Species: Rat Project Nuiber: 02B1CR0012 Sunarized STAR Page: 199 363 000751 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4731 Sex! Resale Group: ( 6 ) FC-143 30 ppa FatE! (Neek= 99) Sacri-ficed in extreais Microscopic Observations (continued): Lyaph Node (thoracic) ' Mantary Eland Mesentery Ovary Pancreas Salivary Gland Siall Intestine Spleen Stosach Urinary Bladder -Malignant lysphoaa, histiocytic -Fibrcadenoia -Malignant lyaphoaa, histiocytic -Malignant lyaphoaa, histiocytic -Acinar atrophy, aarked Malignant lyaphoaa, histiocytic -Not exaained, aissing -Ulcer, aarked -Malignant lyaphosa, histiocytic -Ulcer, aultiFocal, aild -Malignant lyaphoaa, histiocytic The Following tissues were found to be within norsal lia its : Uterus, Thyroid, Parathyroid, Trachea, Esophagus, Pituitary, Heart. Aniaal Nuiber : 19-4732 Sex: Feaale Group: ! 6) FC-143 30 ppa Fate: (Wee*'= 99) Sacrificed in extreais Macroscopic Observations: Fituitary Maasary 61and Adrenal Liver Microscopic Observations: Adrenal Kidney Liver Lung -Raised aass, 0.5 ca dia. -Cystic aass, 4 ca dia., possibly inflaaaed ailk cyst, le ft inguinal area; fira cystic aass, 4 ca dia., possibly tuaor, in right inguinal area; large aass, 12 x 10 x 3 ca, le ft and right axilla. -Right adrenal enlarged; le ft adrenal pale aass, 0.7 ca dia. -Appears swollen and enlarged. -Sinusoidal ectasia, cortex, aarked Cortical degeneration, aoderate Carcinoaa, cortical, unilateral -Pelvic aineralization, aarked Nephrosis, tubular, aarked -Cystcid degeneration, focal, aild Heaatopoiesis, extraaedullary, aild Necrosis, focal, ainiaal -Vascular aineralization, ainiaal Alveolar aacrophages, aild Metastatic neoplass Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page: 200 364 000752 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Vear Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4732 Sex: Feaale 6roup: ( 6) FC-143 30 ppa Fate: (Meek- 99! Sacrificed in extrenis Microscopic Observations (continued): Haaaary Gland Pituitary Spleen Fibroadenoaa Fibroadenoaa Adenoaa Heiatopoiesis, extraaedullary, increased, aild The following tissues ere found to be within noraal lia its : Heart, Uterus, Ovary, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Aniaal Nuaber: 1R-473J Sex: Feaale Group: ( 6) FC-143 30 ppa Fate: (Neek= 105) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Adrenal Kidney Liver Lung Pituitary -No visible lesions. -Sinusoidal ectasia, cortex, aoderate - -Pelvic aineralization, aild -Hepatocyte vacuolation, aultifocal, aild -Vascular aineralization, ainiaal Alveolar aacrophages, aultifocal, aild -Adenoaa The following tissues ere found to be within noraal lia its : Spleen, Heart, Uterus, Ovary, Haaaary Gland, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Aniaal Nuaber: 1R-4734 Sex: Feaale Group: ( 61 FC-143 30 ppa Fate: (Meek1 95) Sacrificed in extreais Macroscopic Observations: Pituitary Haaaary Gland Liver Microscopic Observations: Adrenal Liver Lung Haaaary Gland Pituitary -Heaorrhagic aultilobular aass, 1.2 x C.S ca. -Cystic aass, 3 x 3 x 1.5 ca, in le ft inguinal -area. -Possibly slightly pale. -Sinusoidal ectasia, cortex, aoderate -Hepatocyte vacuolation, periportal, aoderate -Heaorrhage, aultifocal, aild -Lobular hyperplasia, cystic -Adenoaa Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 201 365 OC0753 Suaaarized Single Tabulated Anieal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Tear Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4734 Sex: Feaale Group: ( 6 ) FC-143 30 ppa Fate: (Neek= 95) Sacrificed in extreais Microscopic Observations (continued): Spleen Stoaach -Heeosiderosis, aarked -Ulcer, aultifocal, aild The following tissues ere Found to be within noraal lia its : Kidney, Heart, Uterus, Ovary, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Eland, Pancreas. Aniaal Nuaber: IP-4715 Sex: Feaale Broup: ( 6) FC-143 30 ppa Fate: (Keek= 50) Sacrificed in extreais Macroscopic Ohse-vations: Maaaary Bland Live' Microscopic Observations: Adrenal Liver Lang Parathyroid Skin Spleen -Large Fire aass, 9 x 6.5 x 4.5 ca, ulceated skin surface, right axilla, circular aass, 2.5 ca die., le ft axilla. -Pale areas on a ll lobes. -Cortical vacuolation, Focal, aild Sinusoidal ectasia, cortex, aild -Necrosis, centrilobular, aarked -Vascular aineralization, .ainiaal -Not exaained, not in plane of section -Fibroaa Fib'osarcoaa -Heaatcpoiesis, extraaedullary, increased, ;ld The -tollc:*iir,g tissues were Found to be within noraal U nits: Kidney, Heart, Uterus, Ovary, Stoaach, Urinary Bladder, Thyroid, Trachea, Esophagus, Salivary Bland, Pituitary, Pancreas, Hanary Bland. Aniial Nuaber: 1R-4736 Sex: Feiale Broup: ( 1 FC-143 30 ppa Fate: (Week= 105) Terainal Sacrifice Macroscopic Observations: Microscopic Observations: Liver Parathyroid Pituitary Thyroid -No visible lesions. -Hepatocyte alteration, vacuolated, Focal, ainiaal -Not exaained, aissing -Adenoaa -Not exaained, aissing Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 202 366 000754 gganiMMIIi Suiearized Single Tabulated Anieal Report (continued) Individual Hacroscopic and Hicroscopic Observations Riker Laboratories, Inc. 3H F C -1 4 3 : Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: IR-4736 Sex: Feaale Group: ( 6) FC-143 30 ppa Fate: INeek= 105) Terainal Sacrifice Hicroscopic Observations (continued): - The following tissues were found to be within noraal lia its : Spleen, Kidney, Heart, Lung, Uterus, Ovary, Haaaary Eland, Stoeach, Urinary Bladder, Adrenal, Trachea, Esophagus, Salivary Eland, Pancreas. Aniaal Nuaber! 1R-4737 Sex: Feaale 6rcup: ( 6) FC-143 30 ppa Fate: (Neek= 105) Terainal Sacrifice Hacroscopic Observations: Pituitary Haaaary Gland Hicroscopic Observations: Adrenal Kidney Liver Bast-ary Eland Ovary Pancreas *. * wcr j JUW C . . Y 3 I J Oi i ' U L'ts'us -Raised lass, 0.6 cs d:a. -Bass, 2 x 1.5 cs, in per;real area; cass, 3 x 4 " 1 cc, in -igh.t inguinal a-ea. -Sinusoidal ectasia, cortex, code-ate -Chronic progressive nephropathy, cinita! Pelvic liReralization, aimsal -Hepatocyte vacudatior, periportal, slid -Vascular aineralizatior,, sinusal -Fibroadenosa Fibroader-osa -Tubular hyperplasia, bilateral, eoderate -Not examined, cissin; -Adenotia -Sialadenitis, chronic, slid -Not examned, cissir.g Tha following tissues were found to be within no-sal lis its : Spleen, Hea-t, Stosach, Urinary Bladder, Thyrs:id, Pa-athyrcid, Tracha, Esophagus. Anisal * usher: 1F.-A73B Ses: Fecale Group: ( t i FC-143 30 pps Fate: Otee* 101) Sacrificed in extreiis Hacrcscopic Observations: Haaaary 3!and Adrenal Hicroscopic Observations: Adrenal Kidney -Large subcutaneous aass, 9 x 12 x 5 ce, in right axilla. -Le: t ad-enal slightly enlarged. -Cortical vacuolation, local areas, sodErate Sinusoidal ectasia, cortex, eoderate Nodular hyperplasia, cortex, focal, soderate -Pelvic Bineraiization, ni 1d Species: Rat Project Nuaber: 02B1CRC012 Suaaarized STAR Page: 203 367 000755 Sueaarized Single Tabulated Antal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nuiber: 1R-4738 Sex: Fetale Group: ( 4) FC-143 30 ppe Fate: (Heeks 101) Sacrificed in extretis Microscopic Observations (continued): Liver Lung Maatary Gland Pituitary Skin Stoaach Thyroid -Hepatocyte alteration, basophilic, focal, eild -Vascular aineralization, aild -Not exaained, aissing -No diagnosis, inadequate section -Fibroea -Necrosis, focal, aucosal, aild -Hyperplasia, C cell, focal, aild The following tissues were found to be within noraal U nits: Spleen, Heart, Uterus, Ovary, Urinary Bladder, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Anna! Muster! 1R-4739 Sex: Aeeale Group! ( 6) FC-143 30 ppa Fate: (keel1 105) Terimal Sacrifice Macroscopic Observations: Maaaary Gland Spleen Microscopic Observations: Adrenal Hear t Kidney Liver Lung Maaaary Gland Skin Spleen -Very large aultilobular aass, 14.5 x 10 x 4.5 ca, in the axillary and lateral area. -Enlarged -Sinusoidal ectasia, cortex, acderate Keaatopoipsis, extraaedullary, cortical, aoderate -Myocarditis, chronic nonsuppurative, aultifocal, aild -Protein resorption droplets, tubular, aild Pigaent, conv. tub. epitheliua, aoderate Nephrosis, tubular, aild -Heaatopoiesis, extraaedullary, aild -Vascular aineralization, aild Hyperplasia, septal cell, focal, aild -Not exaained, aissing -Fibrosarcoaa Extensive necrosis and ulceration. No aaatary tissue ir tunor. -Heaatopoiesis, extraaedullary, increased, aarked The following tissues were found to be within noraal lia its : Uterus, Ovary, Stcaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Species: Rat Project Nuaber: 0281CR0012 ST" p,!,; ftoo Summed Single Tabulated Anital Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nuaber: 1R-473S Sex: Feeale Broup: < 6) FC-143 30 ppe Fate: (Week: 105) Tereinal Sacrifice Microscopic Observations (continued): The following tissues were found to be within noria! lie it s (continued): Salivary Bland, Pituitary, Pancreas.' Ar.iaal Nuaber: 1R-474C Sex: Fenale Broup: ( 6) FC-143 30 ppe Fate: (Neek= 105) Teriinal Sacrifice lt>u. __ 1 Macroscopic Observations: Haeeary Bland Microscopic Observations: Adrenal Kidney Lung Nanaary Bland Parathyroid Pituitary Thyroid -Mass, 4 x 3 x 1 ce, in perineal area. -Sinusoidal ectasia, cortex, aoderate Medullary cell hyperplasia, eultifocal, ai Id -Pelvic aineralization, eiId -Hepatocyte alteration, vacuolated, aild Hepatocyte alteration, basophilic, aild -Vascular aineralization, ni Id Perivascular aononuclear in filtra te , aild -Lobular hyperplasia -Not exaained, not in plane of section -Adenoea -Ultieobranchial cyst The following tissues were found to be within nornal lie its : Spleen, Heart, Uterus, Ovary, Stoeach, Urinary Bladder, Trachea, Esophagus, Salivary Bland, Fanc-eas. Aniial Nunber; 1R-474! Sex! Fecale Broup: ! 6) FC-143 30 ppe Fate: (Keek* 97) Sacrificed in extreeis Macroscopic Observations: Pituitary Maneary Bland Microscopic Observations: Adrenal Kidney Lung Haeeary Eland Parathyroid Pituitary -Raised dark eass, 1.3 ce dia. -Nodular lesion, 1 ce dia., in perineal area. -Sinusoidal ectasia, cortex, aoderate -Chronic progressive nephropathy, aild -Vascular aineralization, ainiea! Heaorrhage, focal, aild -Lobular hyperplasia -Not exaained, not in plane of section -Adenoea The following tissues were Found to be within noreal lie its : Spleen, Liver, Heart, Uterus, Ovary, Stoeach, Urinary Bladder, Thyroid, Trachea, Esophagus, Species: Rat Project timber: 0281CR0012 Suiearized STAR Page: 205 369 000757 Suuarized Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3(1 FC-143: Two Year Oral Toxicity-Oncogenicity Study ir Rats Table: 2 Aniial Nuiber: 1R-4741 Sex: Feiale Group: ! 6) FC-143 30 ppi Fate: (Meek= 97) Sacrificed ir, extreiis Microscopic Cbse-vations (continued): " The following tissues were found to be within norsal lin t s Salivary Bland, Pancreas. (continued): Aniial Nuater: 1R-4742 Sex'. Feiale Group: ( t! FC-143 30 ppe Fate: (Keek- 63) Found Dead Macroscopic Observations: Maiaary Gland Adrenal Pituitary Microscopic Observations: Adrenal Esophagus Kidney Liver Lung Mataary Gland Pancreas Parathyroid Pituitary Spleen Thyroid Trachea -Large m ltilobular lass, 10 x 9 x 3 ci, in right axilla; necrotic aass, 4 x 3 ct, in le ft inguinal area. -Possibly slightly enlarged. -Heicrrhagic lass, 0.5 ci dia. -Sinusoidal ectasia, cortex, loderate -Not exalined, lissing -Pelvic sineralization, lild -Necrosis, aultifocal, eild Atrophy, hepatocytes, centrilobular, aoderate -Vascular eineralization, lild -Fibroadenoaa Fibroadenoia -Not exaained, lissing -Not exaiined, lissing -Adenona -Not exaiined, cissing -Not exaiined, lissing -Not exaiined, lissing The following tissues were found to be within :norial l i i i t s : Heart, Uterus, Ovary, Stoaach, Urinary Bladder,, Salivary Gland. Aniial Nuiber: IR-4743 Sex: Feiale Group: ( 6) FC-143 30 ppi Fate: (Meek1 97) Sacrificed in extreiis Macroscopic Observations: Pituitary Mattary Gland Lung Liver -Raised heiorrhagic lass, 1 c i dia. -Circular lass, 2 ci dia, in perineal area. -Areas of consolidation in right anterior and apical lobes. -Possibly Bottled Species: Rat Project Nuiber: 02E1CR0012 Suuarized STAR Page: 2j Suaaarized Single Tabulated Aniaal Report (continued) Individual Racroscopic and Ricrcscopic Observations Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nueber: 1R-4743 Sex: Feeale 6roup: ( 6) FC-143 30 ppe Fate: (Neek= 97) Sacrificed in extreeis Ricrcscopic Observations (continued): Adrenal Kidney Liver Lung Haseary Bland Pancreas Pituitary Urinary Bladder Uterus ' -Sinusoidal ectasia, cortex, eiId -Pelvic eineralizatior., earked -Hepatocyte vacuolation, periportal, derate Hepatocyte alteration, basophilic, focal, rild -Vascular eineralization, tild Pneusonia, acute exudative, local areas, eild Heeorrhage, ultifocal, ni Id -Fibroadenoaa -Acinar atrophy, eild -Adenoaa -Epithelial hyperplasia, siaple, diffuse, eild -Cystic glands, aarked The following tissues were found to be within noreal lie its : Spleen, Heart, Ovary, Stoaach, Thyroid, Parathyroid, Trachea, Esophagus, Salivary 61and, Skin. Ari aal Nueber: 1R-4744 Sex: Feeale Group*. ( 6) FC-143 30 ppe Fata: ikieek* 4B) Found Dead Racroscopic Ofcse-vations: Haaeary Gland Heart Lung Ricrcscopic Observations: Kidney Lung Raaeary Gland Pituitary Spleen -Rass, 8.5 x 7.5 x 4.5 ci, hollow cavity fille d with brown aatter, in le ft inguinal area. -Possibly slightly enlarged. -Rultiple grayish tar, raised nodules, 0.1 - C.3 ca dia.i 2 nodules in le ft lobe, 3 nodules in right cardiac lobe! 2 nodules in right intermediate lobe; 3 nodules in right diaphragsatic lobe. -Chronic progressive nephropathy, ainiaal -Retastatic necolast Heiorrhage, local areas, eild -Adenocarcinoia Extensive necrosis in tucor; areas highly anaplastic. Locally invasive. Rultiple lung aetastases. -No diagnosis, inadequate section -Heaatcpoiesis, extraaedullary, increased, aoderate Species: Rat Project Nueber: 02B1CR0012 ....Smeari zed STAR Page: 207 37 \ &00759 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. JM FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4744 Sex: Feaale Group: ( 6) FC-143 30 ppe Fate: (Week- 4S! Found Dead Microscopic Observations (continued): The f cl Idling tissues were found to be within noraal lia its : Liver, Heart, Uterus, Ovary, Stoaach, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Eland, Pancreas. Aniaal Nuaber: 1R-4745 Sex: Feaale Group: ( 6) FC-143 30 pp* Fate: (Neek= 105) Terainal Sacrifice Macroscopic Observations: Pituitary Hairary Sland Microscopic Observations: Adrenal Esophagus Kidney Lung Haar,ary Sland Ovary Pituitary -Saall raised dark lass, 0.4 ca dia. -Hass, 5 x 4 x 2 ca, in perineal area. -Sinusoidal ectasia, cortex, aoderate -Not exasined, aissing -Chronic progressive nephropathy, aild Pelvic aineralization, aild -Vascular aineralization, aild Fneuaonia, in te rs titia l, chrcnic, aultifocal, aild Alveolar aacrophages, aultifocal, aild -Fibroadenoaa -Tubular hyperplasia, unilateral, aoderate Granulosa cell tuaor, benign, unilateral -Adenora The following tissues were found to be within noraal lia its : Spleen, Liver, Heart, Uterus, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Salivary Gland, Pancreas. Aniaal Nuaber: 1R-4746 Sex: Feaale Group: I 6! FC-143 30 ppa Fate: (Neek= B7! Sacrificed in extresis Hacroscopic Observations: Pituitary Haaaary Gland Spleen Microscopic Observations: Ad'enal Kidney Liver -Enlarged with 0.7 ci dia. aass. -Multilobular aass, 11 x & x 3 ca, in le ft inguinal area. -Slightly enlarged -Sinusoidal ectasia, cortex, aild -Pelvic aineralization, ainiaal -Hepatocyte vacuolation, aultifocal, ainiaal Hepatocyte alteration, basophilic, aultifocal, aild Heaatopoiesis, extraaedullary, aultifocal, ainiaal Species: Rat Project Nuaber: 0281CR0012 Suaaarized STAR Page: 20B 372 '07S0 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3N FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4746 Sex: Feaale Group: ( 6) FC-143 30 ppa Fate: (Week= S7) Sacrificed in extreais Microscopic Observations (continued): Lung Maaaary Gland Pituitary Spleen -Vascular aineralization, ai Id -Adenocarcinoaa -Adenora -Keaatopoiesis, extraaedullary, increased, aoderate The -fallcwing tissues were found to be within noreal lim its: Heart, Uterus, Ovary, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pancreas. Anisal Nuaber: 1R-4/47 Sex: Feaale Group: ( fc) FC-143 30 ppa Fate: (Keek1 105'! Terminal Sacrifice Macroscopic Observations: Maaaary Eland Microscopic Observations: Adrenal Liver Lung Maaaary Gland Ovary Pancreas Skin Spleen -Lobular aass, 5 x 4 x 3 ca, in throat area: lobular aass, 5 x 2.6 x 1.5 ca, in le ft axilla; lobular aass, 7 x 4.5 x 3 ca, in right inguinal area. -Sinusoidal ectasia, cortex, mild Medullary cell hyperplasia, multifocal, mi 1d -Portal aoncnuclear cell in filtra te , mild Porta! bile duct proliferation, mild Heaatopoiesis, extraaedullary, minimal Hepatocyte alteration, basophilic, multifocal, mild -Vascular aineralization, minimal Alveolar aacrophages, aild -Fibroadenosa Fibroadenoaa -Cyst, unilateral -Not examined, aissing -Fitroaa -Heaatopoiesis, extraaedullary, increased, aild The following tissues were found to be within noraal lim its: Kidney, Heart, Uterus, Stoaach, Urinary Bladder, Thy-cid, Parathyroid, Trachea, Esophagus, Salivary Eland, Pituitary. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized STAR Page: 2^ - q .q Suiiarized Single Tabulated flmaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3H FC-143: T*o Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Annal Nuaber: 1R-474B Sex: Fetale Broup: ( 6) FC-143 30 ppt Fate: !Neek= Bl! Sacrificed in extreeis Macroscopic Observations: Pituitary Matiary Bland Adrenal Kidney Microscopic Observations: Adrenal Esophagus Kidney Liver Lung Mainary Bland Parathyroid Pituitary Thyroid Trachea Urinary Bladder -Enlarged due to red tass, 1.3 x 1.2 x 0.B ca. -Subcutaneous aass, 3.5 x 3 . ct, le ft axillary; subcutaneous aass, 1.5 x 2 ca, le ft inguinal. -Right adrenal darkened and enlarged, 1.4 ci dia., fille d with reddish liquid. -Stall cyst, 0.4 cn dia., on surface of le ft kidney. -Sinusoidal ectasia, cortex, larked Cortical degeneration, loderate -Not exaiined, ussing -Chronic progressive nephropathy, aiId -Portal lononudear cell in filtra te , lild Hepatocyte alteration, basophilic, lu ltifo c a l, ild -Vascular lineralization, iiId Heaorrhage, local areas, Bild -Fibroadenota Adenocarcinoia Ealactccele -Not exaiined, ussing -Adenoia -Not exaiined, lissing -Not exaiined, lissing -Epithelial hyperplasia, siiple, local areas, ild The fcIloNirg tissues ere found to be within norial I i i i t s : Spleen, Heart, Uterus, Ovary, Stoiach, Salivary Gland, Pancreas. Aniial Nuiber: 1R-4749 Sex: Feiale Broup: ( 6) FC-143 30 ppi Fate: (Neelf= B2) Sacrificed in extreiis Macroscopic Observations: Pituitary Maiiary Bland Microscopic Observations: Adrenal Kidney -Heaorrhagic lass, 1 x 0.5 ci dia. -Stall ilk cyst present. -Sinusoidal ectasia, cortex, larked -Chronic progressive nephropathy, aiId Pelvic lineralization, lild Species: Rat Project Nuiber: 02B1CR0012 Sunarized STAR Page: 210 374 000762 Suaaarized Single Tabulated Aniaal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniaal Nuaber: 1R-4749 Sex'. Feaale Group: ( 6) FC-143 30 ppa Fate: (Heek= 82) Sacrificed in extreais Microscopic Observations (continued): Lung Maaaary 61and Pituitary -Vascular ainerslization, aild Heaorrhage, local areas, aild -Balactocele -Adenoaa The following tissues aere found to be within noraal lia its : Spleen, Liver, Heart. Uterus, Ovary, Stoaach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary 6!and, Pancreas, Eye, Skin. Aniaal Nuaber: 1R-4750 Sex: Feaale Broup: < b) FC-143 30 ppa Fate: (Neex= 97) Found Dead Macroscopic Observations: Kaaaary Eland Pituitary Microscopic Observations: Adrenal Harderiar, Bland kidney Liver Lung Maaaary Bland Parathyroid Pituitary Thyroid Uterus -Multilobular aass, 0.3 x 2 ca, ir. right inguinal area; aultilobular aass, 8.5 x 5 x 4 ca, in right axilla. -Enlarged, 0.9 ca dia. -Sinusoidal ectasia, cortex, aild -Adenocarcinoaa Not described at necropsy. Probably froa c lin ica lly described atrophic right eye. -Pelvic aineralization, aild -Hepatocyte vacuolation, aultifecal, aild -Edeaa, local areas, aild -Fibroadenoaa Balactocele Fibroadenoaa -Not exaained, aissing -Adenoaa -Not exaained, aissing -Cystic glands, aarked The following tissues aere found to be within noraal lia its : Spleen, Heart, Ovary, Stoaach, Urinary Bladder, Trachea, Esophagus, Salivary 61ar.d, Pancreas. Species: Rat Project Nuaber: 02B1CR0012 Suaaarized 5TAR Page: 211 375 000763 Sum m ed Single Tabulated Anieal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Anieal Nueber: 1R-4751 Sex: Feeale 6roup: ( 4) FC-143 30 ppt Fate: (Neek- 42) Found Dead Macroscopic Observations: Hataary Bland Microscopic Observations: Kidney Lung Skin Spleen Stoaach -Subcutaneous tass, B x 5.5 x 4.5 ca., right axilla -Pelvic fineralization, ainital -Vascular fineralization, ainital -Fibrota -Heeatopoiesis, extraaedullary, increased, federate -Ulcer The following tissues were found to be within noreal l i f i t s : Liver, Heart, Uterus, Ovary, Mattary Bland, Urinary Bladder, Adrenal, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Gland, Pituitary, Pancreas. Anital Nueber: IR-4752 Sex: Fetale Broup.' ( 6) FC-143 30 ppt Fate: lkleek= 105! Terainal Sacrifice Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Kidney Lung Ovary Pancreas Pituitary -Raised beaorrhagic aass, 0.4 ci dia. -Sinusoidal ectasia, cortex, foderate Nodular hyperplasia, cortex, foderate -Chronic progressive nephropathy, c:Id Pelvic fineralization, tiniaal -Vascular fineralization, mild -Cyst, bilateral Tubular hyperplasia, bilateral, foderate -Hyperplasia, is le t ce ll, eild -Adenofa The following tissues were found to be within noreal l i f i t s : Spleen, Liver, Heart, Uterus, Haeeary Bland, Stoeach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Salivary Bland. Anital Nueber: 1R-4753 Sex: Fetale 6roup: ( 6) FC-143 30 ppt Fate: (Week= 105) Terainal Sacrifice Macroscopic Observations: Pituitary Skin Hataary 61and -Enlarged with stall dark lesions, 0.2 ct dia. -Hair less on head. -Lobular tass, 4 x 3 x 2 ct, in perineal area. Species: Rat Project Nueber: 0281CR0012 Suttarized STAR Page: 212 376 000764 Suiiarized Single Tabulated Anisal Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3M FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Aniial Nusber: 1R-4753 Sex: Fesale Group: ( 6) FC-143 30 pps Fate: iHeek= 105) Tersinal Sacrifice Microscopic Observations (continued): Adrenal Kidney Liver Lung Massary Gland Ovary Pituitary Spleen ' -Sinusoidal ectasia, cortex, sild -Pelvic sineralization, unilateral, sarked -Porta! sononudear cell in filtra te , sild Portal bile duct proliferation, sild Hepatocyte vacuolation, sultifocal, sild Hepatocyte alteration, vacuolated, sild -Vascular sineralization, sild -Fibroadenosa -Tubular hyperplasia, bilateral, soderate -Adencsa -Not examined, sissing The following tissues were found to be within norsal lis its : Heart, Uterus, Stosach, Urinary Bladder, Thyroid,, Parathyroid, Trachea, Esophagus, Salivary 61and, Pancreas. fir, i sal Nster : 1R-4754 Sex! Resale 6roup: ( 6) FC-143 30 pps Fate: (Reek 105) Te-sinal Sacrifice Macroscopic Observations: Massary SI and Microscopic Observations: Ad'enal Kidney Liver Lung Massary Gland Ovary Pituitary Spleen -Lobulated sass, B x & x 3 cs, in inguinal and perineal areas; sass is quite necrotic and cystic. -Sinusoidal ectasia, cortex, soderate -Pigsent, conv. tub. epithelius, brown, soderate -Portal sononudear cell in filtra te , sild Portal bile duct proliferation, sild Hepatocyte vacuolation, sultifocal, sild Hepatocyte alteration, vacuolated, sild -Vascular sineralization, sild Pneusonia, in te rs titia l, chronic, sultifocal, sild Alveolar sacrophages, sultifocal, sild -Adenocarcinosa -Cyst, unilateral -Adenona -Hesatcpoiesis, extrasedullary, increased, soderate The following tissues were found to be within norsal lis its : Heart, Uterus, Stosach, Urinary Bladder, Thyroid, Parathyroid, Trachea, Esophagus, Species: Rat Project Nusber: 0261CR0012 Sussarired STAR Page: 213 377 000765 Suiaar;zed Single Tabulated Aniial Report (continued) Individual Macroscopic and Microscopic Observations Riker Laboratories, Inc. 3K FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Table: 2 Ar.iaa Nueber: 1R-4754 Sex! Feeale Group: ( 6) FC-143 30 ppi Fate: (Ueek= 1C5) Terainal Sacrifice Microscopic Observations (continued): - The folloving tissues Mere found to be Mithin norial l i i i t s (continued): Salivary Bland, Pancreas. Aniial Nueber: 1R-4755 Sex: Feeale Group: ( 61 FC-143 30 ppi Fate: (Week= 105) Terminal Sacrifice Macroscopic Observations: Pituitary Microscopic Observations: Adrenal Esophagus Heart Kidney Liver Lung Ovary Parathyroid Pituitary Thyroid Trachea -Heiorrhagic uss, 0.7 ci dia. -Sinusoidal ectasia, cortex, derate -Not exaiined, lissing -Myocarditis, chronic nonsuppurative, ultifocal, mild -Chronic progressive nephropathy, liniea! Pelvic lineralization, lild -Hepatocyte alteration, basophilic, focal, ild * -Alveolar lacrophages, focal, a iniial -Tubular hyperplasia, bilateral, derate -Not exaiined, aissing -Adenoia -Net exaiined, aissing -Not exaiined, aissing The fclloeing tissues Mere found to be Mithin norial l i i i t s : Spleen, Uterus, Matiary Gland, Stoeach, Urinary Bladder, Salivary Gland, Pancreas, Skin. Species: Rat Project Nuiber: 028ICR012 izedSueur STAR Page: 214 378 C00766 Tissus Inventory Table: 3 Riker Laboratories, Inc. 3N FC-143: Teo Year Oral Toxicity-Oncogenicity Study in Rats - One Year In te rii Project Nueber: 0281CR0012 Species: Rat Tissue Naae Oose Sroup Naae: CONTROL 0 ppa 1111111111111111111111I 11 RRRRRR- RRRRRRRRRRRRRRRRRRR Anieal Nuebers 333333333333333444444444 4 555555555555555555555666 6 1 1 222344 55567787B8BB9001 2 6 7 0 2 75 3 6 0 l98 0 5 0 8 25 B9 0 1 8 0 0 Sex N H N N N N MH H N H H K H n f F F F F F F F F F Adrenal Aorta Bone Harrou Brain Esophagus Eye Heart Kidney Large Intestine Liver Lung Lyaph Node (aesenteric) Haeaary Eland Ovary Pancreas Parathyroid Pituitary 4+++444+44444444444444444 + + ++ 4 4 4 4 +4 ++ 4 4 4 4 4 4 4 4 4 4 4 4 4 ++4+44444+++44C4444444444 4++444444 ++ 44 44 44 44 4444 4 4+44444444+4444444444444 4 +44 4 4 +4 4 4 +4 4 44 4 4 4 4 4 4 4 4 4 4444+4+444444444444444444 4 4 4 4 +4 4 4 ++ 44 44 44 4 4 4 4 4 4 4 4 4 444444444 4+44 44c 444 44 444 444444444++4444444444444 4+++444++444444444444444 c +c + ++44444C444444C44 ++-4 444 4444 444 4 4 4 4 4. 4 4 4 4 4 44444444+44444444 4444444 c c cc +c +4+44CC4CCc c 4C44+C4 4 +c +4 4 4 +44 44 4 4 4 4 4 44 4 44 4 4 4 Prostate 4 4 44 +4 44 ++44 4 4 4 Salivary 61and Snail Intestine Spinal Cord Spleen +4++4444 +4444444444444444 +44444444444444444444444 +++ 44 44 444444c 4 44C44 4444 4 ++++4 ++4 + 44 4 4 4 44 4 4 4 44 44 4 Stoaach Testis/Epididyais Thyroid Trachea Urinary Bladder Uterus +444++c 444444444444 44 444 4 4 4 4 +4 4 4 +4 4 4 44 4 cc+c4c 4444444444444444444 4+44+44444444444444444444 4+++4444 +4444444c4444444C 4444444444 --------------------------- jhe fo il ouing tissue(s) ere not required by protocol --------- Nesentary --------- - + Skin - --------- -- -------- -- ---------------------- Ureter ............................................................ A + indicates that a diagnosis uas aade. A - indicates that no diagnosis or coaaent uas aade. A c indicates only a nondiagnostic coaaent was aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 215 379 Tissue Inventory (continued) Table: 3 Riker Laboratories, Inc. 3H FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats - One Year Interie Project Nueber: 0281CR0012 Species: Rat Tissue Naae Dose Broup Nane: CONTROL 0 ppa ! I 1 11 RRRRR' Ani sal Nuebers 44444 66666 23334 9 0 12 0 Sex F F F F F Adrenal Aorta Bone NarroM Brain Esophagus Eye Heart Kidney Large Intestine Liver Lung Lyiph Node (eesenteric) Nasiary Bland Ovary Pancreas ++444 c+444 ++444 +444 +444 ++444 ++444 ++444 ++444 4.4 4 4 4 44444 44C + + 4 44 4 4 4 44 4 4 4 44 + 4 Parathyroid Pituitary C CC + C 4 44 44 Prostate Salivary 61and 4 +4 + 4 Seall Intestine 4 44 4 4 Spinal Cord Spleen 4 44 44 4 44 4 4 Stoeach 4 44 4 4 Testis/Epididyais Thyroid 4C+ Trachea 44444 Urinary Bladder Uterus 44C++ 44444 The follouing tissue(s) Here not required by protocol Hesentary Skin Ureter A + indicates that a diagnosis uas aade. A - indicates that no diagnosis or coeeent eas sade. A c indicates only a nondiagnostic coeeent eas eade. Please reFer to the Single Tabulated Anieal Report. Tissue Inventory Page: 216 380 CO0768 Tissue Inventory (continued) Table: 3 Riker Laboratories, Inc. 3H FC-H3: Two Year Oral Toxicity-Oncogenicity Study in Rats - One Year In te rii Project Nuaber: 02B1CR0012 Species: Rat Tissue Naee Dose Eroup Naee: FC-1A3 300 ppt 1I111 11111111111111111111 RRRRRRRRRRRRRRRRRRRRRRRRR Aniaal Nuabers-------------- ---------------- -- ------------------------------ -3333333333333334444444444 555556 6 6 6 6 i 6 i 6 6 6 t 6 6 6 i 6 i 6 6 0BB99O1 1 2 2 2 2 3 4 4 4 5 5 5 6 6 6 7 7 7 4892843702678232256469146 Sex H H H R N H H H H H H H H H H F F F F F F F F F F Adrenal 4444444444444444444444444 Aorta c +c ++c ++c ++++++++c +++++c + Bone Harrow 4444444444444444444444444 Brain ++++++++++4 ++++++++++++++ Esophagus Eye 4444444444444444444444414 4444444444444444444444444 Heart 4444444444444444444444444 Kidney 4444444444444444444444444 Large Intestine 44444444444444444444444c* Liver 4. 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Lung 4444444444444444444444444 Lyaph Node (aesenteric) 444444444444cc++++c+44444 Naeaary Bland ---------------------------- ----------- ( * ' 4 * c * * * Ovary - - - --------------------------- - - - - - - 4 4 4 4 4 4 4 4 4 4 Pancreas 4444444444444444444444444 Parathyroid c+ccccc+cccc+cccc+++++cc+ Pituitary 4 444[ 4 44 4 * C * C * * M [ t 4(4444 Prostate 4 4 4 4 4 4 4 4 4 C + + C + + .............................. ........ Salivary Eland Stall Intestine 44444C +++++++++++++++++++ 4444444444444444444444444 Spinal Cord 4444444444444444444444444 Spleen 4444444444444444444444444 Stoaach 4444444444444444444444444 Testis/Epididyais 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 ---------------------------- ---- --------------- Thyroid Trachea 4 4 C + + + 4 4 4 4 4 4 4 C + + + + + + ++ + + + 4444444444444444444444444 Urinary Bladder 444c44444444c+++++++++*++ Uterus 4444444444 --------------------------- 7he following tissue(s) were not required by protocol -------------------------- Hesentary -------------------------------------------------- ---------------- Skin - - - --------- 4 ---------- -- --------------------------------- Ureter -------------- -------------------------------------- -- ---------- A 4 indicates that a diagnosis as aade. A - indicates that no diagnosis or coaaent as aade. 381 A c indicates only a nondiagnostic coaaent as aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 217 000769 Tissue Inventory (continued) Table: 3 Riker Laboratories, Inc. 3H FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats - One Year Interie Project Nuaber: 02S1CR0012 Species: Rat Tissue Naae Dose Group Naie: FC-143 300 ppt 1 1 1 1i RRRRR- Aniaal Nuabers 44444 b6 6 b7 8 B9 9 0 79294 Sex F F F F F Adrenal 4 4 44 4 Aorta Bone tlarroH Brain Esophagus Eye Heart Kidney Large Intestine 44444 ++ ++ +++++ c 4 +++ + ++ + ++++ ++++* +++++ Liver 44444 Lung 44444 Lyaph Node (aeser.teric) Haeaary Gland ++c + c+4 ++ Ovary 44444 Pancreas 44444 Parathyroid CCHt Pituitary 44444 Prostate Salivary Gland +++++ Saall Intestine Spinal Cord 44444 ++ +++ Spleen Stoaach 44444 +++++ Testi s/Epi didyais Thyroid Trachea Urinary Bladder +c ++c ++* + ++++ Uterus t ++ --------------------------- The f o ilOKing tissueCs) uere not required by protocol Nesentary ------------ Skin .............. Ureter . + - ------ 382 A ind ic a te s that a diagnosis Has ia d e . A - ind ic a te s th a t no diagnosis or coeaent aas aade. A c indicates only a nondiagnostic coaaent Has aade. Please refer to the Single Tabulated Aniaal Report. C O 0 7 7 0Tissue Inventory Page: 218 Tissue Inventory Riker Laboratories, Inc. 3N FC-143: To Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaber: 02B1CR0012 Species: Rat Table: 4 Tissue Naae Dose Group Nate: CONTROL 0 ppa 1111111111111111111111111 RRRRRR- RRRRRRRRRRRRRRRRRRR Aniial Nuebers - -------------------------- - --------------- - -------------3333333333333333333333333 55555555555555555555 55555 1 i 2 2 2 2 2 n4. 2 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 B9 1 3 4 5 6 8 9 0 12 3 4 b7 B9 0 1 2 4 5 7 B Sex H H MN N H N H H N H H It H H H H H H H H H H N H Adrenal Aorta Bone Marrox Brain Esophagus Eye Heart Kidney Large Intestine Liver Lung Lyaph Node (aesenteric) 4 + 44 +4 4 4 4 4 4+ 44+ 44 +4 +4 4 4 4 +4 4 4 4 4 + 4 4 + 4 + + 4 4 4 + 4 4 4 + + + + + 4 + 4 + 4 + 4 4 + 4 4 4 4 4 4 c4 4 4 4 4 4 4 + 4 4 + + + 4 4 4 4 +4 4 4 4 +4 4 4 +4 4 4 4 c 4 +4 +4 +4 +4 4 4 4 4 4 +4 4 4 4 4 4 4 4 4 4 4 4 4 4 +4 +4 4 4 c 4 +c 4 4 4 4 4 4 C + + 4 4 4 4 +4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 +4 4 4 4 4 4 4 + 4 4 4 4 4 4 4 +4 4 4 4 4 4 4 4 +4 4 4 4 ++4 4 4 4 +4 4 +4 4 4 +++ 4 4 4 4 ++4 ++++++4 4 4 4 +4 4 +++ +4 4 4 4 4 +4 4 4 4 +4 4 4 4 4 4 4 4 4 4 4 4 4 +4 4 4 c 4 +4 4 4 4 +4 +4 c 4 4 4 4 4 4 4 4 4 Naaaary Gland Ovary Pancreas Parathyroid Pituitary Prostate Salivary 61and Stall Intestine Spinal Cord +4 4 +4 +4 4 4 4 4 4 4 4 4 c 4 4 4 4 4 4 4 4 4 c 4 c 4 c c 4 4 c 4 4 4 4 c 4 c c c 4 4 +c ++c ++ 4 4 4 4 + + 4 4 4 4 4 4 +4 4 4 4 4 4 4 4 4 4 +++4 4 4 +4 c 4 4 4 4 4 4 4 4 +c c 4 4 4 4 4 +4 +4 4 4 4 4 c 4 4 4 4 4 4 4 ++4 4 4 +++ +4 + 4 + + + 4 4 4 4 4 + 4 4 4 4 4 4 4 4 4 + ++ 4 +4 4 4 4 4 4 4 4 4 4 4 4 4 4 c4 4 4 + + + Spleen 4444+444++44+44+44 44 ++444 Stoaach Testis/Epididyais Thyroid Trachea Urinary Bladder ++44++444+4+44444++4 44444 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 +c 4 4 4 4 4 c 4 4 4 4 4 4 4 4 4 +4 4 c 4 c 4 4 4 4 c + ++ +4 4 4 4 4 4 4 4 4 4 4 4 +4 +4 4 4 4 4 4 + + t +4 4 +4 4 4 4 4 4 4 4 4 4 cc 4 ++++ Uterus --------------------------- Tl,e follouing tissue(s) ere not required by protocol Bone --------- - + - - - ---------------- C litoral Gland Harderian 61and ------------ - ----------------------. . . . --------------- . . . . . Lyeph Node ------------ . . . . . . . . . . Lyeph Node (abdoainal) ------------- - - - - - - - - - Lyeph Node (thoracic) -------------------- -- ------------- -- Hesentary -------------- ---------------- -------- A + indicates th at a diagnosis aas eade. A - in dicates th at no diagnosis or coaeent was Bade. 383 A c indicates only a nondiagnostic coaaent as Bade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 219 000771 Tissue Inventory (continued) Riker Laboratories, Inc. 3M FC-143: To Year Oral Toxicity-Oncogenicity Study in Rats Project Nueber: 0281CR0012 Species: Rat Table: 4 Tissue Naae Preputial Eland Skin Soft Tissues (abdoaen) Soft Tissues (head) Soft Tissues (leg) Soft Tissues (neck) Soft Tissues (thorax) Thyaus Unidentified Tissue General Consent Dose 6roup Naae: CONTROL 0 ppa 1111 11111111111111111111 RRRRRR' RRRRRRRRRRRRRRRRRRR Aniaal Nuabers 33333333.3 33333 33333333333 5555555555555555555555555 1122222223333333334444444 B9 13 4 5 b 6 9 0 12 3 4 6 7 8 9 0 1 2 4 5 7 B Sex N H N N N N N H H N N N N N N H N H H K K R n N N ----------------------- - ---------------------------------+ - + + --------- + ................ + + - - - + - - + ------------------------------- - ------------------------------------- - --------- ------------------------------------------ -- ----------------------------------------------------------------- ------------------------------ -- ------------------------------ -- ---------------- -- --------------------------------------------- - - - ---------------- - ----------------- ---------- -- ----------------------------------- -- ------------------- --------------------------------- A indicates that a diagnosis aas aade. A - indicates that no diagnosis or coaaent aas Bade. 384 A c indicates only a nondiagnostic coaaent aas aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 220 CC0772 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Project Nueber! 02B1CR0012 Species: Rat Table: 4 Tissue Naae Dose Group Naae: CONTROL 0 ppe 1 1 1 1 I'1 1 1 1 1 1 1 1 1 I I 1 1 1 1 1 1 1 1 1 RRRRRR- RRRRRRRRRRRRRRRRRRR Aniaal Nuabers ------------------------- -- ---------------------------------- - 3333333333333333333333333 5555555555555555555555555 455555556 4i 6 i 6 i i i 77777777 9 2 3 4 5 &7 0 0 12 3 45 b7 9 123 4 6 7 8 9 Sex H N N N H N N N H N N N H N N N N N N N N N N N N Adrenal 4 4 4 4 4 4 4 4 4 4 4 4 c4 4 4 4 44 4 4 4 4 4 Aorta Bone Marrov 44 4 4 4 4 4 4 4 4 4 44 c4 4 4 4 4 4 4 4 44 4 +4 4 4 4 4 4 4 4 C4 4 C4 4 4 4 4 4 4 4 4 4 4 4 Brain 4 444 4 4444 444 44 44 4444 44 4 44 Esophagus 444 4444444444C44 44 44 44444 Eye 4 4 C 4 4 4 4 4 4 4 4 4 4 c 4 4 4 4 4 4 4 4 4 4 4 Heart 4 4 4444 444 444 44 444 4 44 44 4 44 Kidney 4 44 44 4 444 444 44 4 44 44 4 4 4 4 44 Large Intestine 4 4 C4 4 4 4 4 4 4 4 4 4 C4 4 4 4 4 4 4 4 44 4 Liver 4 .4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Lung 44 4444 4 4 4 444 4444 44 44 44 44 4 Lyaph Node (aesenteric) 4 4 C4 4 4 4 4 4 4 4 4 4 C4 4 4 4 4 4 C4 4 4 4 Haasary Bland Ovary Pancreas + + C + + + + + + + + + CC + + + + + + + + + + + Parathyroid Pituitary Prostate c c + c c c + c + CC + CCC + + C C C C C + + C ++++++++ + + 4 + +C + + +C + ++++ + + ++++++++ ++ + + +C ++ + ++++++++ Salivary Gland Saall Intestine Spinal Cord Spleen Stoaach Testis/Epididyais Thyroid Trachea + + C + + + + + + + C + CC+ + + + + + C + + + + + + C + + + + + ++ + + + C + + +++++++++ ++++++++ +C++C++++++++++++ ++++++++ +++++++++++++++++ 4 + + + + + 4 + ++++++++++C++++++ + + + ++++++++++++++ ++++++++ C + + + + + + + + C + + + C+ + + + + + + + + + + + + + + + + ++ ++ ++ + C + + + ++++++++ Urinary Bladder 4 + 4 + 4 4 + + + + + + + C+ + + + 44 + C + + + Uterus --------------------------- The foiioaing tissue(s) sere not required by protocol --------------------- Bone ----------- -- -------- --------------------------- ----------- C litoral Gland ---------------------------- --------------------------------- Harderian Gland ----------- -- ------------------------ -- -------- ----------- Lyaph Node ------------ -- ------------- ------------------------ -------- Lyaph Node (abdoainal) -------------- -------- -- ------------- -- ------------ - - Lyaph Node (thoracic) -------------------------------------------------------------- Hesentary -------------- ------------------------------ + ----------- A + indicates that a diagnosis aas aade. A - indicates that no diagnosis or consent uas aade. A c indicates only a nondiagnostic consent aas aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 221 CC0773 385 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: To Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaber: 02B1CR0012 Species: Rat Tibie: 4 Tissue Nate Preputial Bland Skin Soft Tissues (abdoien) Soft Tissues (head) Soft Tissues (leg) Soft Tissues (neck) Soft Tissues (thorax) Thyaus Unidentified Tissue General Coeeent Dose Group Nate: CONTROL 0 ppa 1 1 1 1 I'll 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 l 1 1 RRRRRRKRRRRRRRRRRRRRRRRRR Ani sal Nuabers------ -- ------------------------- -- ------------- -- ----------3333333333333333333333333 5555555535555555555555555 4555555566666666677777777 9234567801234567912346789 Sex H n H H H H H N H H H f l H H H H H H H H H H H H M ----------------------- - -------------------- - --------------.............................. ------ -- -------- -- ------------------------ ------------------- --------------------- -- ---------------- -- ------------------------------------------------ ------------- -- ------------------- -- ----------------------- -- ------------- -- ------------------------------------------------------------------ ---------------- - - ----------------------- -- ------------------- * ------------- * ' ------------------------------------------ -- ------------------- -- r ----------------- -- -------------------------------------- -- A indicates that a diagnosis as aade. A - indicates that no diagnosis or coaaent as aide. 386 A c indicates only a nondiagnostic coaaent as aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 222 000774 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Tea Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaber: 0281CR0012 Species: Rat Table1. 4 Tissue Naae Dose Broup Naae: CONTROL 0 ppa 1111111111111111111111111 RRRRRR- RRRRRRRRRRRRRRRRRRR Aniaal Nuabers 4444444444444444444444444 5555555555555555556666666 77788BB8B9999999990000000 4790 1 3 46 7 123456789 0 2 3456 7 Sex F F F F F F F F F F F F F F F F F F F F F F F F F Adrenal Aorta Bone Narron Brain ++4 4 4 4 + 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4+4c444444 44 c4 444444 4c444 44+4444444444444444444444 444444 +4444444444444 44444 Esophagus + + 4 c4 4 4 44 4 4 4 4 4 44 4 4 4 4 4 C 4 4 c Eye + 4 4 4 4 + 4 4 + 4 4 4 4 4 4 4 4 c c c 4 4 4 4 4 Heart Kidney Large Intestine 4+444++4+4444444444444444 44444++4444444444444444 4+ 4 + 4 + 4 4 4 4 4 44 4 4 4 4 44 4c44 4 Liver Lung 4+444444444444444444444 ++4++444+4444444444444444 Lyaph Node (sesenteric) Naaaary Gland Ovary Pancreas 4 ccc4 + + 4cc4 c4 cC 4 4 44 4 4 44 4 ++44+44444444444444444444 4 + 4 4 4 4 4c4 4 44 44 4 4 4 4 4 4 4 4 +C 4 4 +4 44 4 +4 4 4 4 c4 4 4 4 4 4 4 4 4 4 4 4 Parathyroid 4 +ccccccccCcccccccccccCCC Pituitary 4+44++444444444444444444 Prostate Salivary Gland Saall Intestine Spinal Cord Spleen Stoaach c+4 4 4 +4 c44 4 4 4 C 4 4 4 4 4 44 4 4 c f4 4 4 4 4 4 4 4 4 4 4 c4 44 4 4 4 4 4 4 44 4 4 4 4 4 4 4 ++4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 +4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 +4 4 4 + 4 + 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Testi s/Epididyais Thyroid Trachea Urinary Bladder Uterus 4 4 4 4 +4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 +4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 +4 +4 +4 4 4 +4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 ++4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 The follouing tissue(s) nere not required by protocol Bone C litoral Gland Harderian Bland Lyaph Node Lyaph Node (abdoainal) Lyaph Node (thoracic) Nesentary A + indicates that a diagnosis uas aade. A - indicates that no diagnosis or consent as aade. 387 A c indicates only a nondiagnostic consent mbs aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 223 000775 Tissue Inventory (continued) Riker Laboratories, Inc. 311 FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaberl 0281CR0012 Species: Rat Tibie: 4 Tissue Naae Preputial Gland Skin Soft Tissues labdoaeni Soft Tissues (head) Soft Tissues (leg! Soft Tissues (neck) Soft Tissues (thorax) Thyaus Unidentified Tissue General Coaaent Dose Group Naae: CONTROL 0 ppe 1111111111111111111111111 R R R R R R'R R R R R R R R R R R R R R R R R R R Anieal Nuabers ------------------------------------------------- - - - - - 4444444444444444444444444 55555555555555555566 6 6 6 6 6 7778888889999999990000000 6790134671234567890234567 Sex F F F F F F F F F F F F F F F F F F F F F F F F F ------------------------- ----------------------------------------- - + .............. + .................................... ----------------- -- ---------------------* - - * ---------------------------- ------------- -------- -- ------------------------------------------------------------------------ - ------ - ------------------------------------------------------------------------ -- ---------- ---------------------------------------- -- ------------------------------ - - - - - ------------------------- ---------- -------------------------------------------------------------------- -- ---------- ------------- 388 A + indicates that a diagnosis was aade. A - indicates that no diagnosis or coaaent aas aade. A c indicates only a nondiagnostic coaaent aas aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 224 000776 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC--143: Tno Year Oral Toxicity-Oncogenicity Study in Rats Project Nuiber: 0261CR0012 Species: Rat Table: 4 Tissue Nase Dose Sroup Nane: CONTROL 0 ppe lllll-llllllllllllllllllll RRRRRR- RRRRRRRRRRRRRRRRRRR Aniaal Nuebers ----------------- -- -----------. . . . -----------. . . . . 4444444444444444444444444 6666 666666 AA66 AAAA666AA6A 0111111111222222223333333 91234567B9123456783456789 Sex F F F F F F F F F F F F F F F F F F F F F F F F F Adrenal 4444444444444444444444444 Aorta 44 444C44 44 4[ 44 444 4C H H 4 ( Bone Harrou 4444444444444444444444444 Brain 4444444444444444444444444 Esophagus 4 4 4 C 4 4 4 4 C C C + C + C + + CCCC + + C + Eye 4 4 C + + + + 4 + C 4 4 4 4 C + + + 4 4 C + + 4 4 Heart 4444444444444444444444444 Kidney 4444444444444444444444444 Large Intestine C4 4 t *4 M 4 H M M M 4 t H I M Liver 4444444444444444444444444 Lung 4444444444444444444444444 Lyaph Node (aesenteric) 4444444444444444444444444 Naaaary Eland 4 4 4444 CCC + + + + + + + + + + + 444C + Ovary- 4444444444444444444444444 Pancreas 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4444 Parathyroid CCCCCCCCCCCC + CCCCCCCCC4 C4 Pituitary 4444444C + +4C44444444C + +C+ Prostate Salivary 61and 444444444444444444C4C 444C Saall Intestine 4444444444444444444444444 Spinal Cord 4444C + + 4 4 4 4 4 4 4 4 C 4 4 4 4 4 4 4 4 4 Spleen 4444444444444444444444444 Stoaach 4444444444444444444444444 Testis/Epididyais Thyroid 4444444444444444444444444 Trachea 4444444444444444444444444 Urinary Bladder 4444 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Uterus 4444444444444444444444444 --------------------------- The folloing tissue(s) ere not required by protocol -------------------------- Bone Clitoral Bland Harderian 61and Lyaph Node Lyaph Node (abdoainall Lyaph Node (thoracic) Hesentary 389 A 4 indicates that a diagnosis as aade. A - indicates that no diagnosis or coaaent as aade. A c indicates only a nondiagnostic coaaent as aade. Please refer to the Single Tabulated Aniaal Report. 0 0 0 7 7 7Tissue Inventory Page: 225 Tissue Inventory (continued) filter Laboratories! Inc. 3H FC-143: To Year Oral Toxicity-Oncogenicity Study in Rats Project Nuiber: 0281CR0012 Species: Rat Table: 4 Tissue Naie Preputial Bland Skin Soft Tissues (abdoaen) Soft Tissues (head) Soft Tissues (leg) Soft Tissues (neck) Soft Tissues (thorax) Thyaus Unidentified Tissue Beneral Coaaent Dose Broup Naoe: CONTROL 0 ppi 11111-11111111111111111111 RRRRRR- RRRRRRRRRRRRRRRRRRR Aniaal N u ib e rs------ . . . . . . . ---------- . . . ---------------------- 4444444444444444444444444 A6 AAA4 6 A6 AAAA6 A4 AAAAAAAAA 0111111111222222223333333 9 123 45 4 7 8 9 123 4 5 4 78 3 4 5 4 7 B9 Sex F F F F F F F F F F F F F F F F F F F F F F F F F - - - - ----------- ---------------------........................+ - - + -----------+ ---------------------------- - -----------------------. . . . . . . ------------. . . . . . . . --------------------------------------------- -- ------------------------ -- -------- -- ------------------------ ----------------------- -- . . . . . . ------------ ------------- . . . . . . --------------- . . . . . 390 A + indicates that a diagnosis as aade. A - indicates that no diagnosis or coaaent as aade. A c indicates only a nondiagnostic coaaent as aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 224 000778 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Project Nuiber: 0281CR0012 Species: Rat Table: 4 Tissue Naae Dose 6roup Naie: FC-143 300 ppa 1111111111111111111111111 RRRRRRRRRRRRRRRRRRRRRRRRR Aniaal Nuabers - - - --------- -- -- - - ---------------------------- 3333333333333333333333333 555555555555556 6 6 6 6 6 6 6 6 6 6 BB8B8B999999990000000001 1 123567013456790123567B901 Sex n N N N H H N H K H H H I l H N N H I l H H H H n N R Adrenal Aorta Bone Harroe Brain Esophagus Eye Heart Kidney 444444 444444 444444 444444 444444 444444 444444 444444 4 4 4 4 4 4 4 4 4 4 4 4 4 444444 4 4 4 4 4 4 4 4 4 4 4 4 4 444444 + 4 44 c + C 4 + + 4 4 4 4 4 4 4 4 44 4 44 4 4 4 4 4 4 4 4 4 4 4 4 4 c 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 c 4 4 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 44 4 44 4 4 4 4 4 4 4 4 4 4 4 4 Large Intestine 4 4 4 4 4 4 4 4 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Liver +. + + + + + 4 4 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Lung Lyaph Node (aesenteric) 4 4 4 4 4 4 4 4 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 44 4 44 4 4 4 4 4 4 4 4 4 4 4 4 Raasary Gland Ovary Pancreas 444444444444 4444444444444 Parathyroid + C + + + CC + CC + + + + + + + C + C4 + C + C Pituitary 444444C + 4444 44C4444444444- Prostate 444444444444 4444444444444 Salivary Gland 4C4444444444 4444444444444 Saall Intestine 444444444444 4444444444444 Spinal Cord 4 4 4 4 4 4 4 4 4 4 C 4 44C ++ + + + 4 4 4 4 4 Spleen 444444444444 4444444444444 Stoaach 444444444444 4444444444444 Testis/Epididyais 444444444444 4444444444444 Thyroid + C + + + 4C + + 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 c Trachea 444444444444 444444444444c Urinary Bladder 4444 44444444 4 4 4 4 4 4 4 4 4 4 4 4 4 Uterus --------------------------- jhe follouing tissue(s) were not required by protocol Bone --------- -- --------------------------- Clitaral Gland ------ -- ------------------------------ Harderian Gland --------------------------------------- Lyaph Node ----------------------- -------------- Lyaph Node (abdoainal) ------------ - -------------------- Lyaph Node (thoracic) ------ -- ----------------------- - - Nesentary - - - ------------- - - - - - - 391 A 4 indicates that a diagnosis aas aade. A - indicates that no diagnosis or coaaent uas aade. A c indicates only a nondiagnostic coaaent aas aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 227 000779 Tissue Inventory (continued) RiIter Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Project Nuiber: 0281CR0012 Species: Rat Table: 4 Tissue Naee Preputial Gland Skin Soft Tissues (abdoaen) Soft Tissues (head) Soft Tissues (leg) Soft Tissues (neck) Soft Tissues (thorax) Thyaus Unidentified Tissue General Coaaent Dose Group Naae: FC-143 300 pp* 11111-11111111111111111111 RRRRRR- RRRRRRRRRRRRRRRRRRR Aniaal Nuabers-------------- -- ---------- ----------------------------------- - 3333333333333333333333333 5 5 5 5 5 5 555 5 55 5 5 6 &6 6 6 6 6 6 6 6 6 8 8 8 8 6 8 9 9 9 9 9 9 9 9 0 0 0 0 0 0 0 0 0 1,1 1 2 3 5 6 7 0 1 3 4 3 6 7 9 0 1 2 3 5 6 7 8 9 0* 1 Sex H N H K M M M H t l H H M H H H H H K H R N H H I l H - 392 A indicates that a diagnosis as aade. A - indicates that no diagnosis or coaaent as aade. A c indicates only a nondiagnostic coaaent as aade. Please refer to the Single Tabulated Aniaal Report. C 0 0 7 S OTissue Inventory Page: 228 ^ Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Project Nueber: 02S1CR0012 Species: Rat Table: 4 Tissue Nate Dose Group Naae: FC-143 300 ppa 1 1 1 1 -1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 RRRRRRRRRRRRRRRRRRRRRRRRR Aniial Nuabers 3333333333333333333333333 b b b b b b b b b b b b b b b b b b b b b b bb b 1111112222223333333334444 2 4 5 6 B9 13 4 5 B9 0 12 3 4 5 6 7 9 0 14 5 Sex H H H H H H H H H H H H H H H H H H M H H H H H H Adrenal Aorta Bone Harrow Brain Esophagus Eye Heart Kidney Large Intestine Liver Lung Lyaph Node (eesenteric) 4 + + 4+ + + + + + + + + + + + 4 + + + + + + + + ************************* ************************* ************************* ************************* ************************* ************************* ************************* ************************* *^* * * * * * * * * * * * * * * * * * * * * * * * ************************* ************************* Kaauary 61 and Ovary Pancreas ********************z**** Parathyroid **z***z***z*****z***z**** Pituitary 4 4 4 4 4 4 4 C + ++ + C+ + + + + ++ ++ + ++ Prostate + C + + + + + + + ++ + + + + + + + + + + + + ++ Salivary 61and + + C+ C + + + ++ + + + + + + + +C+ + + + + Stall Intestine 4444444444444444444444444 Spinal Cord 4444444444444444444444444 Spleen 4444444444444444444444444 Stoaach 4444444444444444444444444 Testis/Epididyais 4444444444444444444444444 Thyroid 4444444444444444444444444 Trachea 4444444444444444444444444 Urinary Bladder 4444444444444444444444444 Uterus --------------------------- y(,e following tissue(s) were not required by protocol ----------- Bone -------------- -- ------------------------------ + Clitoral Gland --------- ------------------------ -- ------------- Harderian Gland --------------- Lyaph Node ---------------------------- -- ------------------- Lyaph Node (abdoainal) -------------------- - -------------------------- Lyaph Node (thoracic) --------------------------------------------------- Hesentary --------- - ------------------------------------- 393 A * indicates that a diagnosis was aade. A - indicates that no diagnosis or coaaent was Bade. A c indicates only a nondiagnostic coaaent was aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 229 CC0781 Tissue Inventory (continued) Hiker Laboratories, Inc. 311 FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Project Nueber*. 02B1CR0012 Species: Rat Table: 4 Tissue Naie Preputial Gland Skin Soft Tissues (abdoeen) Soft Tissues (head) Soft Tissues (leg) Soft Tissues (neck) Soft Tissues (thorax) Thyeus Unidentified Tissue General Coiaent Dose Broup Naie: FC-143 300 ppe 1 1 1 1 M 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 11 1 R R R R R R-R R R R R R R R R R R R R R R R R R R Anisal Nuebers------ -- -------- -- ---------------- -- - - -------------------3333333333333333333333333 1111112222223333333334444 2454891345890123456790145 Sex H H H N H N N H H H N R M H H H M H M R R R H H I 1 394 A indicates that a diagnosis as aade. A - indicates that no diagnosis or coeient as eade. A c indicates only a nondiagnostic coaaent as eade. Please refer to the Single Tabulated Anieal Report. Tissue Inventory Page: 230 000782 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: To Year Oral Toxicity-Oncogenicity Study in Rats Project Nuiber: 0281CR0012 Species: Rat Tibie: 4 Dose 6roup Nate: FC-143 300 ppi 1 1 1 1 1-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 11 1 1 1 RRRRRR- RRRRRRRRRRRRRRRRRRR Aniial N u ib e rs------ -- ---------------- -- -------------------------------------4444444444444444444444444 Tissue Naie 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 b i b b t> b 6 7 77 1 3 4 56 7 8 9 0 1 3 47 8 9 0 l 2 3 5 7 B 0 23 Sex F F F F F F F F F F F F F F F F F F F F F F F FF Adrenal Aorta Bone Harro Brain ++++444+ 4 + 4 4 4 4 4 4 4 4 4 4 4 4 4 4 ++ c 44444 4 4 4 4 4 C + 4 4 4 4 4 4 4 4 +++++++4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 ++++44444 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Esophagus Eye Heart Kidney Large Intestine Liver Lung C C H c ++ C CC + C C C C C 4 C C + + C + 4 4 4 4 ++c + C + 4 C 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 + 44 4 4 4 4 4 4 4 4 4 4 4 4 +c++ C + 4 + 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 + 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 + 44 + + + + ++++4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Lyiph Node iiesenteric) Hainary Gland OvaryPancreas C + + ++c4 4 4 4 4 4 4 4 4 4 4 C 4 4 4 4 4 4 4 4 4 ++c ++ 4 + 4++4 4 4 4 4 4 C C C + C + + + ++++ C 4 4 4 4 4 4 4 4 4 4 4 4 4 4 + + C + +4++4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Parathyroid Pituitary +c +c c c c c C C 4 4 C + C C 4 C 4 C C + C c 4 4 4 4 + + + +44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Prostate Salivary Gland Stall Intestine C + + + C + + C+ C + + + C+ + + + + + C + + + + 444444C + + 4444444444444444 Spinal Cord 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 + 444 Spleen + + +++ + + + + + + + + + + + + + + + + + + + + Stoiach + + +++ + + + + 4 + + + + 4 + 4 + + + + + + + + Testis/Epididyiis Thyroid 4 + +++ C + 4 + C + + + C + + + + + + + C + C C Trachea + + +++ C + + + + + + + C + + + + + + + + + C + Urinary Bladder - + + C + + C + + + C + 4C + + + + + + + + C + + + Uterus + 4 + + + + + + + + ++ + + + + + ++ + ++ ++ + The fo llo iing tissue(s) were not required by protocol -------------------------- Bone C litoral Gland Harder!an Gland Lyiph Node Lyiph Node (abdoiinal) Lyiph Node (thoracic) Hesentary 395 A + indicates that a diagnosis as iade. A - indicates that no diagnosis or conent as lade. A c indicates only a nondiagnostic coiient as iade. Please refer to the Single Tabulated Aniial Report. Tissue Inventory Page: 231 00783 Tissue Inventory (continued) Riker Laboratories, Inc. 3N FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaber: 0281CR0012 Species: Rat Table: 4 Tissue Naae Preputial Eland Skin Soft Tissues (abdoaen) Soft Tissues (head) Soft Tissues (leg) Soft Tissues (neck) Soft Tissues (thorax) Thyaus Unidentified Tissue General Coaaent Dose Broup Naie: FC-143 300 ppa 1111111111111111111111111 RRRRRRRRRRRRRRRRRRRRRRRRR Aniaal Nuabers - - - - -------------------------------------------------------4444444444444444444444444 6 6 6 6 6 6 6 6 6 i fc 6 t 6 6 6 t t b 4444444455555556666666777 134567B901347890 123578023 Sex F F F F F F F F F F F F F F F F F F F F F F F F F ------------------------------- - - + - + ------------------------------- - - - - ------ -- ------------- --------------------------------------- -- --------------------------------------- 396 A + indicates that a diagnosis as aade. A - indicates that no diagnosis or coaaent was aade. A c indicates only a nondiagnostic coaaent aas aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 232 CG0784 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-14J: Two Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaber: 02B1CR0012 Species: Rat Table: 4 Dose Group Nate: FC-143 300 ppe 1111111111111111111111111 RRRRRRRRRRRRRRRRRRRRRRRRR Anieal Nuabers-------------- ------------- -------------------------------------4444444444444444444444444 Tissue Nate 7777BB8B8BB89999999900000 57 8 9 0 12 3 4 5 bS0 13 4 5 i 7 8 0 12 3 5 Sex F F F F F F F F F F F F F F F F F F F F F F F F F Adrenal Aorta Gone Harrow ++++++++c ++ +++ +++++++++ ++++++++c ++++++++++ c ++++ ++++++++++++ + +++++++++ Brain +++ ++ +++++++++++ ++ ++++ Esophagus c c +c c c c cc c ++++++++++cc c Eye + + + + C + C + + + + + + + + + + + + + + c Heart Kidney Large Intestine ++++ ++ + + + +++ ++++++++++ +++++++ + + ++ +++++++ ++++ ++++ C+ C+ + ++++++++ +++++++ Liver +-+ + + + + + + + + + + + + + + + + + + + + Lung + + + + + + + + + + + + + + + + + + + + + + + Lytph Node (eesenteric) ++++c+c +c +* ++ +++++c++++ Hataary Gland ++++++++c ++c +++++++++++++ Ovary Pancreas ++++C+ + ++++++++ +++++++ ++++++C+ + + + ++++++++C+ + Parathyroid c c +cc c cc ++C+ + C + + ++cc +++ Pituitary +++++++++ ++ + + ++++++++++ Prostate Salivary Gland + + + + +-C + C C + + + + + + + + + + + + + + C Stall Intestine ++++C+C+++++++++ ++ +++++++ Spinal Cord + + + + + + + + + ++ + + + + + + + + + + + Spleen ++++++++++++++++++++++ Stoaach ++++++C++++++++++++++++++ Testis/Epididyais Thyroid + + ++ + + C + C + + + + + + + + + + + C + + + + Trachea + + + + +. + + + C + + + + + + + + + + + + + + + + Urinary Bladder + + C+ + + C + + + + + + + + + + + + + + + + + C Uterus + + ++ C+ C + + + + + + + + + + + + + + + + + + The Polloaing tissue(5) were not required by protocol ------------------------------- Bone Clitoral Gland Harden an 61and Lytph Node Lytph Node (abdotinal) Lytph Node (thoracic) Hesentary A + indicates that a diagnosis was aade. A - indicates that no diagnosis or cotaent was Bade. 397 A c indicates only a nondiagnostic coaaent was aade. Please refer to the Single Tabulated Anital Report. Tissue Inventory Page: 233 000785 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaber! 0281CROC12 Species: Rat Table: 4 Tissue Naae Preputial Bland Skin Sott Tissues (abdoaen) Soit Tissues (head) Soit Tissues (leg) Soit Tissues (neck) Soit Tissues (thorax) Thyaus Unidentified Tissue Beneral Coaaent Dose Sroup Naae: FC-143 300 ppa 1111111111111111111111111 RRRRRR- RRRRRRRRRRRRRRRRRRR Aniaal Nuabers - - - - ------------------------- ---------------------4444444444444444444444444 66t i b6666i 6 bt b66h77777 7777B8888BBB9999999900000 S7 B9 0 12 3 4 5 bB0 13 4 5 6 7 B0 ! 2 3 5 Sex F F F F F F F F F F F F F F F F F F F F F F F F F ------ - ------------ --------------- -------------- ----------------- -- -------------------------------- + 398 A + indicates that a diagnosis aas aade. A - indicates that no diagnosis or coaaent aas aade. A c indicates only a nondiagnostic coaaent aas aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 234 Tissue Inventory (continued) Riker Laboratories, Inc. 3ft FC-143: Two Year Dral Toxicity-Oncogenicity Study in Rats Project Nuaber: 02B1CR0012 Species: Rat Table: 4 Dose Sroup Naae.` FC-143 30 ppi 1111T11111I 11111111111111 RRRRRR- RRRRRRRRRRRRRRRRRRR Aniaal Nuabers ------------ - ---------------------------------- - -----------3333333333333333333333333 Tissue Naae 4 4 4 4 5 5 5 5 55 5 5 5 5 6 b t> t> 6 6 6 b i i 7 6 7 B 9 0 1 2 3 45 6 7 6 9 0 1 2 3 4 5 6 7 B 9 0 Sex HIt ft N 11 II ft N H H H H H H H H ft ft N ft 11 N HH Adrenal 4444444444444444444444*44 Aorta ----------- - * -------------- --------------------------- - - Bone Harrow ---------------------------------------------------------------- -- Brain ------------ -- ------------------- Esophagus + + + + + C+ + + + + + + + + + + + + + + + + C+ Eye --------- -- ------------- - - + - - - * - - - 4 -------- -- Heart 4444444444444444444444444 Kidney 4444444444444444444444444 Large Intestine Liver ----------------- ------------------- -- ----------------------+ - 4. 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Lung 4444444444444444444444444 Lyaph Node (aesenteric) + ftaaaary SI and --------------------------------------- -- ---------------- - - - Ovary -------------- --------------------------- -- ---------------- - - Pancrea5 C+ C++C+++4++4444444444444 Parathyroid Pituitary 4 4 4 4 4 4 4 4 C + C44CC + C44C + 44C + 4 4 C + 4 4 4 4 4 4" 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 Prostate 4444444444444444444444444 Salivary Sland 4 4 4 4 4 4 4 4 4 4 c c`+ 4 4 t 4 4 4 4 4 4 4 c 4 Stall Intestine ---------------------------- -- ------------------------------ + - Spinal Cord Spleen ------------------------------------ -- ---------- ---------------- 4444444444444444444444444 Stoaach 4444444444444444444444444 Testi s/Epididyai s 4444444444444444444444444 Thyroid 4444444444444H4t*44444C* Trachea Urinary Bladder 44444444444444444444444C + 444444444444444444444^444 Uterus ..................................................................... ... --------------------------- The following tissue(5 ) were not required by protocol Bone Clitoral Gland ------ -- ---------- ---------- -------. . . . . -------------- ----------- Harderi an Sland ----------------- -------- - - - - - Lyaph Node --------- -- --------------------------- Lyaph Node (abdoainall -- 4 - ----------------------------------------------- ---- Lyaph Node (thoracic) -------------------------- - --------- Hesentary ------ -- ---------------- -- ---------- 399 A 4 indicates that a diagnosis was aade. A - indicates that no diagnosis or coaaent was aade. A c indicates only a nondiagnostic coaaent was aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 235 CC07S7 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: To Year Oral Toxicity-Oncogenicity Study in Rats Project Kuiber: 0281CR0012 Species: Rat Table: 4 Tissue Naee Preputial Bland Skin Soit Tissues (abdoeen) Soit Tissues (head) Soit Tissues (leg) Soit Tissues (neck) Soit Tissues (thorax) Thyeus Unidentified Tissue General Coeeent Dose Broup Naae: FC-143 30 ppa 1 1 1 1 fl 1 1 1 1 l 1 1 1 1 1 1 1 1 1 1 1 1 1 1 RRRRRR' RRRRRRRRRRRRRRRRRRR Aniial Nuebers-------------- ------------- . . . . ------------- ------------3333333333333333333333333 6666666666666666666666666 4444555555555546666666647 6 7 B0 1 2 3 4 5 6 7 B9 0 1 2 3 4 5 6 7 B9 0 Sex P H H Hfl H N H H K H N K MH H H R H N K H MK H -------------------------- - ----------------- - --------------- ..................................................... --------- - ---------------------------- - --------------------------------------------------------------------------------- - ------ -- -------------------------------------- -- --------------------- -- ------------------------ -- ------------------- . . . . ----------------- -- ------------------- -- ---------------- -------- - ----------------- ------------- -- ------------------------------------------- - ------------ - -------------------------- --------- . . . . . ---------- ------------------- 400 A indicates that a diagnosis as eade. A - indicates that no diagnosis or coiaent was aade. A c indicates only a nondiagnostic consent as aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 236 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaber: 02B1CR0012 Species: Rat Table: 4 Tissue Naae Do1se1 61ro1upl -Nlalae:1 F1C1-14131301 p1p1t 1 1 1 1 1 1 1 1 1 1 RRRRRR' RRRRRRRRRRRRRRRRRRR Aniial Nuabers - ----------------- ----------------------------------------------- 3333333333333333333333333 bbbbbbbbbbbbbbbbbbbbbbbbb 7777777770888888888999999 1234567B901234567B90 12345 Sex Adrenal 4444444444444444444444444 Aorta Bone Barroa Brain Esophagus Eye C+ + + + + C+ + + + + + + + + + + + + + + + + C - -------------------- + -- -----------4 ---------------------- Heart 4444444444444444444444444 Kidney 4444444444444444444444444 Large Intestine liv e '- +++++++++++++++++++++++++ Lung 4444444444444444444444444 Lyaph Node (aesenteric) Haaaary Bland + Ovary Pancreas 4444444444444444C ++++++++ Parathyroid CC + C + + C + + + + + C + + + C C C C C + + + + Pituitary 4 4 4 4 4 4 4 4 4 4-4 4 4 4 4 4 4 4 C 4 4 4 4 4 C Prostate 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 C + + 4 + 4444 Salivary Gland [ 444444 44444 44 [ [ H t H M H Seal! Intestine Spinal Cord Spleen 44444444 44444444 444444444 Stoaach 44444444 44444444 444444444 Testi s/Epididyais 44444444 44444444 444444444 Thyroid [ 4 44 44 44 44444444 444444444 Trachea [ 44 444 44 44444444 444444444 Urinary Bladder 44444444 44444444 444444444 Uterus --------------------------- The following tissue(s) ere not required by protocol -- Bone ------ - - Clitoral Bland Harderian Bland ----------------------- - ----------------. . . . . . . -------------------------- Lyaph Node --------- - ------------ ----------------- Lyaph Node (abdoainal) ------ -- ---------------- -- ---------------- Lyaph Node (thoracic) -------------------- -- ---------------------- Hesentary ------------ 4 ---------- ---------------- 4 A 4 indicates that a diagnosis aas aade. A - indicates that no diagnosis or coaaent m s Bade. 401 A c indicates only a nondiagnostic coaaent as aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 237 Tissue Inventory (continued) Riker Laboratories, Inc. 3N FC-143: Tao Year Oral Toxicity-Oncogenicity Study in Rats Project Nutber: 02B1CROC12 Species: Rat Table: 4 Tissue Naae Preputial Bland Skin Soft Tissues (abdoeen) Soit Tissues (head) Soit Tissues (leg) Soit Tissues (neck) Soit Tissues (thorax) Thyaus Unidentified Tissue General Coaaent Dose Group Naae: FC-143 30 ppn 1 1 1 1 1' 1 1 ! 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 RRRRRR- RRRRRRRRRRRRRRRRRRR Anieal Nuabers------ -- ------------- -- ------------------------------ -- -------3333333333333333333333333 6666666666666666666666666 7777777778888BBBB88999999 1234567890123456789012345 Sex N H N N H N N N N N H H N I I H H N N H H N N N N N -------------------------------------* --------- + ................+ -------- ----------------- * - - - ---------------------------------- - - - ----------------------- '---------- * * --------- -- --------------------------- ------------------------------------------------------------------- -------------------------------. . . -------- A + in d ic a te s th a t a d ia g n o s is aas Bade. A - in d ic a te s th a t no d ia g n o s is o r coaaent as aade. A c indicates only a nondiagnostic coaaent aas aade. Please reier to the Single Tabulated Aniaal Report. Tissue Inventory Page: 238 402 000790 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Tno Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaber: 0281CR0012 Species: Rat Table: 4 Tissue Naie Dose Group Naie: FC-143 30 ppa 11111-11111111111111111111 RRRRRR- RRRRRRRRRRRRRRRRRRR flnieal Nuebers-------------------- -- ---------- ------------------- -- ---------4444444444444444444444444 7777777777777777777777777 0000111111111122222222223 6 7 B9 0 12 3 4 5 6 7 8 9 0 123 45 6 7 6 9 0 Sex F F F F F F F F F F F F F F F F F F F F F F F F F Adrenal 4444444444444444444444444 Aorta Gone Harro Brain Escphagus Eye 444444444444:444444444444 . . . ---- . . . -------+ + ----- Heart 4444444444444444444444444 Kidney Large Intestine 4444444444444444444444444 Liver Lung 4444444444444444444444444 4444444444444444444444444 Lyiph Node (aesenteric) Naeaary Gland 4444444:44444444:4:444444 Ovary Pancreas Parathyroid Pituitary 4444444444444444444444444 444C+ + + + C+ + + + + + C + 44 4444 44 C C C C C + + + + C + + CC + C + + C + C + + C4 444444444444444:444444444 Prostite Salivary Gland 4444444444444C4CC44444444 Stall Intestine ----------------------------------------------------------------- 4 - - --------------- Spinal Cord Spleen 4444444444444444444444444 Stoiach 4444444444444444444444444 Testi s/Epidi dyais Thyroid 4444444444444444444444444 Trachea Urinary Bladder 4 4 4 4 4 4 4 4 4 4 4 *4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 H * 4 4 4 44 4 4 4 4 4 4 C4 [ 4 4 4 4 Uterus Bone 4444444444444444444444444 The following tissue(s) ere not required by protocol ----------------------------------------------------------- -- ------------------- -- Clitoral Gland Harderian Gland Lyaph Node ------------------------------------- - ----------------- ----------------- -- -------------------------------------- - + --------------------------+ ----------- Lyaph Node (abdoainal) Lyaph Node (thoracic) ----------------- ------------- -- ---------------------------------------------------------------- - - - - - - - - Hesentary --------- - --------------------------------------------- + 403 A 4 indicates that a diagnosis uas aade. A - indicates that no diagnosis or coaaent as aade. A c indicates only a nondiagnostic couent as aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 239 000791 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats Project Nusber: 02S10R0012 Species: Rat Table: 4 Tissue Naie Preputial Gland Skin Soft Tissues (abdoeen) So-ft Tissues (head) Soft Tissues (leg) Soft Tissues (neck) Soft Tissues (thorax) Thyiu s Unidentified Tissue General Coiient Dose 6roup Naie: FC-143 30 ppi 1111111111111111111111111 RRRRRRRRRRRRRRRRRRRRRRRRR Anieal Nuebers ------------------------------------------------------------------4444444444444444444444444 7777777777777777777777777 0000111111111122222222223 6 7 8 9 0 12 3 4 5 6 7 B9 0 12 3 4 5 6 7 B9 0 Sex F F F F F F F F F F F F F F F F F F F F F F F F F - -------------------------- - ------------------------------------ + - - -------- ----------------------- - ------------ - ----------------------- -- ----------------------------------------- . . . . . ------------------------ - -------------------------------------. . . . . . . . . . . -------------------------------------------------- -- ------------- - - - - - - - --------------------------------------------- 404 A indicates that a diagnosis as aade. A - indicates that no diagnosis or coaaent as aide. A c indicates only a nondiagnostic coaaent as aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 240 0C0792 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Two Year Oral Toxicity-Oncogenicity Study in Rats Project Hueber: 02B1CR0012 Species: Rat Tifale: 4 Tissue Naee Dose 6roup Naie: FC-143 30 ppa 1111111111111111111111111 RRRRRRRRRRRRRRRRRRRRRRRRR Amsal Nuebers---------------------------- -- ---------- ------------- -- -------4444444444444444444444444 7777777777777777777777777 3333333334444444444555555 123456 78 90 1234 56 7B90 12345 Sex F F F F F F F F F F F F F F F F F F F F F F F F F Adrenal + + + + + + + + + + + + + + + + 4 + Aorta Bone Harro Brain Esophagus Eye Heart Kidney Large Intestine Liver Lung 4 4 4 + + + + 4 4 4 4 C + + C + + C+ + + + + + C . . . ----------- - - ------------ 4 - - - ----------- 4444444444444444444444444 4444444444444444444444444 4444444444444444444444444 4444444444444444444444444 Lyeph Node (eesenteric) Naasary 61and Ovary + + + + + + + CC + + + + + + + + + + + + + + + + 4444444444444444444444444 Pancreas Parathyroid P it u it a ry + 4 4 4 4 4 C + + + + C + + + + C + + + + ++ ++ + + + + CC ++ + C CC + + + + + C + C + + + + C 4444444c H M t c M M * M ( H ( Prostate S a liv a ry Gland ---------------------------------------------------------------------------- - - - - - C4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 S ta ll Intestine Spinal Cord Spleen Stoeach + - ----------------------------------------------------------------------------------- -- ------------- ------------------------------------------------ - - - - - ---------------44444444444044444444440 ++ 44 + + + + + 4 4 4 + 4 4 4 4 4 4 4 + + + 4 + + + T e s tis /E p id id y e is Thyroid Trachea Urinary Bladder -------------------------------------- - ---------------------------------- - -------------- +44 + +c + + + + + c+ + + + +c+ c + + + +c 4 4 4 4 4 + 4 4 + + + C+ + + + + C ++ + + + +C 4 4 + 44 + 44 + ++ 4 4 + + + + + ++ + + + + + Uterus 4 4 4 + ++ C + + + + ++ + + + ++ ++ + + + ++ ---------------------------------------- The Following tissu e (s) ere not required by protocol -------------------------------------- Bone ------------------------- --- ---------------------------- --- ------------------------------------ C lit o r a l Gland Hardeman Gland Lyeph Node Lyaph Node (abdoeinal) ------------------------- --- ---------------------------------------------------- --------------------------------------------- ---------------------------------------------+ - - - - ----------------------------------------- --- --------------- ------------------------ -------------------------------------------------------------------------------------------------------------- Lyeph Node (thoracic) Hesentary + ------------------------------------------------------------ ----------------------------------- ---------------------------------------------------------- -------------------------------- --- 405 A + indicates that a diagnosis eas aade. A - indicates that no diagnosis or concent as cade. A c indicates only a nondiagnostic consent as aade. Please reFer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 241 -00793 Tissue Inventory (continued) Riker Laboratories, Inc. 3H FC-143: Tuo Year Oral Toxicity-Oncogenicity Study in Rats Project Nuaber: 0281CR0012 Species: Rat Table: 4 Tissue Naae Preputial Bland Skin Soft Tissues (abdoaen) Soft Tissues (head) Soft Tissues (leg) Soft Tissues (neck) Soft Tissues (thorax) Thyaus Unidentified Tissue General Coaaent Dose Broup Naie: FC-143 30 ppe 111111111 1111111 11I1 11111 RRRRRR- RRRRRRRRRRRRRRRRRRR Aniaal Nuabers------ -- ------------- -------------------------------------------4444444444444444444444444 7777777777777777777777777 3333333334444444444555555 12345678901234567B9012345 Sex F F F F F F F F F F F F F F F F F F F F F F F F F -------------------- -- ------------------- ---------------------- --------- + - + - + + -------------------- -- ---------------- -- ---------------- -------- ------------------------- --------------------------- -- ----------- ---------------------------- -------------------------------------- -------------------------------------------------- ---------------- ---------------------------- ------------- ------------------------------------------------ -- ------------------- -- ---------------- ------------------------- -------- -- ---------------- ------------- -------------- -- ------------------------ -- ---------------------- 406 A indicates that a diagnosis uas aade. A - indicates that no diagnosis or coaaent uas aade. A c indicates only a nondiagnostic coaaent uas aade. Please refer to the Single Tabulated Aniaal Report. Tissue Inventory Page: 242 fC0794 APPENDIX ITEM E STATISTICAL METHODS ]. For memo dated February 11, 1985; see Tables 12-18 2. For memo dated September 24, 1985; see Tables 19 and 20 407 000795 Internal Correspondence Appendix Item E To: Chuck F. Chesney - Riker Path and Tox - 270-3S-05 From Sally E. McCarville - Riker Res Data Ops - 270-3A-01 Subject: Statistical Analysis for FC-143 in Rats Date: February 11, 1985 The laboratory values and organ weight data for the study of fluoro carbon FC-143 in rats have been analyzed, and the results are presented in the attached tables. The statistical methods used to analyze the data are described in the following paragraphs. Statistical Methods The means and standard deviations for percent organ weight to body weight ratios, organ weight to brain weight ratios, and labora tory data were determined separately for each sex and dose group. These data were analyzed using Bartlett's test for homogeneity of variance. If this test was not significant at a = 0.001, the data were further analyzed by comparing each treated group to the control group using a two-tailed Dunnett's test at the a = 0.05 significance level. The results of Dunnett's test have been indicated by asterisks on the mean tables. If Bartlett's test was significant at a = 0.001, the data were ranked and a two-tailed Dunnett's test was performed on the ranks. These results have been indicated by the pound sign (#) on the mean tables. References Bartlett's Test Anderson, V.L. and McLean, R.A. (1974), Design of Experiments: A Realistic Approach, New York: Marcel Dekker, Inc., 16-22. Dunnett's Test Winer, B.J. (1971), Statistical Principles in Experimental Design, New York, McGraw-Hill Book Company, 201-204. 408 Appendix Item E Page 2 Statistical Analysis for FC-143 in Rats SEMremr 02/11/85 Rank Transformations Conover, W.J., and Iman, R.L. (1981), "Rank Transformations as a Bridge Between Parametric and Nonparametric Statistics", The American Statistician, Vol.35, No. 3, 124-129. If you have any questions regarding the analyses, please let me know. SEM :emr Att. c: Cathy E. Ludemann Len JT Slblnski MEE/RWH 4U9 000797 Internal Correspondence APPENDIX ITEM E To: From: Subject: Date: L. J. Sibinskt - Riker Path and Tox - 270-3S-05 < S. E. McCarville - Riker Res Data Ops - 270-3A-01 Statistical Analysis of Microscopic Findings for FC-143 in Rats September 24, 1985 The major microscopic findings of the Two Year Oral (Diet) Toxicity-Oncogenicity Study of Fluorocarbon FC-143 in Rats were statistically analyzed. For each organ/lesion classifica tion the sexes were analyzed separately using a two-tailed Fisher's Exact Test comparing each treated group to the controls. An <*= o.05 significance level with Bonferroni's adjustment for multiple comparisons was used within each organ/lesion/sex category. If the expected value of each cell was greater than 20,-then Yates' corrected Chi-Square test was used. An asterisk on the summary tables indicates a significant difference between the controls and the treated group. References Fisher's Exact Test: Conover, W. J., (1971), Practical Nonparametric Statistics, New York, John Wiley and Sons Inc., 162-164. Yates' Corrected Chi-Square: Fleiss, Joseph L., (1973), Statistical Methods for Rates and Porportions, New York, John Wiley and Sons Inc., 14-15, 19-20. J .I <7H* Cs~Jbk S. E. McCarville :mjm c: MEE/RWH 410 C00798 APPENDIX ITEM F GROUP MEAN BODY WEIGHTS, INDIVIDUAL BODY WEIGHTS AND FEED JAR WEIGHTS OF MALE RATS RECEIVING F1UOROCHEMICAL FC-143 IN DIET FOR TWO YEARS NOTES: Code 1 indicates a control group rat weight Code 2 indicates a FC-143 - 300 ppm group rat weight Code 3 indicates a FC-143 - 30 ppm group rat weight Codes 11, 12, 13 indicates the total feed jar weight for the previous rat All weights are in grams 4 000799 APPENDIX ITEM F Two Year Oral (Diet) Toxicity - Oncogenicity Study of Fluorocarbon FC-143 in Rats Group Mean Body Weights (g) _+ Standard Deviation Males Study Week 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 50 52 Control - 0 ppm Mean BW + SD (N) 165.3 + 270.9 + 334.0 + 390.7 T 429.2 + 456.2 + 475.5 493.2 + 502.9 + 515.3 + 526.8 + 542.3 + 550.4 + 561.0 + 567.5 + 576.3 + 580.6 + 582.9 + 591.0 + 599.4 + 608.4 + 612.9 + 619.8 + 623.5 + 626.1 + 639.2 + 638.6 + 10.5 16.4 25.1 31.0 37.3 42.7 43.4 47.7 48.9 48.7 49.5 52.1 53.0 54.3 55.0 56.7 57.4 62.5 59.7 59.4 61.6 61.2 62.3 64.3 63.4 67.0 70.1 (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (64) (64) (64) (64) (64) (64) (64) (64) (64) 300 ppo Mean BW + SD (N) 162.1 + *234.3 + *276.7 + *308.6 + *353.2 + *380.1 + *398.0 + *412.8 + *425.4 + *436.0 + *447.4 + *456.1 + *464.2 + *475.0 + *484.9 + *497.2 + *505.7 + *511.8 + *514.2 + *524.8 + *535.2 + *540.9 + *550.8 + *552.0 T *558.5 + *566.7 + *570.1 + 11.0 21.7 31.8 38.6 39.7 44.9 46.7 47.4 47.5 48.4 48.7 48.9 49.4 49.4 51.4 51.8 52.5 52.5 53.1 53.2 56.0 57.9 58.0 61.2 64.0 64.7 66.2 (65) (65) (65) (65) (65) (65) (65) (65) (65) (65) (64) (64) (64) (64) (63) (63) (63) (63) (63) (63) (63) (63) (63) (63) (63) (63) (63) 30 ppm Mean BW + SD (N) 167.0 + 271.0 + 328.5 + *369.4 + *410.3 + 441.5 + 458.1 + 475.4 + 487.9 + 498.5 + 512.1 + *519.4 + *526.3 + 538.9 + 546.2 + 558.6 + 566.4 + 571.3 + 575.4 + 584.0 + 592.5 + 600.5 + 610.4 + 612.1 + 618.9 + 627.1 + 633.6 + 9.8 14.7 22.9 30.8 37.1 44.2 47.5 48.6 52.5 52.8 53.6 54.7 56.7 59.7 61.8 61.3 62.3 63.3 64.6 65.6 69.0 69.1 69.7 71.0 72.3 74.2 76.2 (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (50) (49) (49) (49) (49) (49) (49) (49) --a Number of animals weighed * Significant difference from Control at the 5% level (Dunnett's t Test; a - 0.05) 412 C008G0 APPENDIX ITEM P Two Year Oral (Diet) Toxicity - Oncogenicity Study of Fluorocarbon FC-143 in Rats Group Mean Body Weights (g) _+ Standard Deviation Males Study Week 54 56 58 60 62 64 66 68 70 72 74 76 78 80 82 84 86 88 90 92 94 96 98 100 102 104 Control - 0 ppm Mean BW + SD (N) 300 ppm Mean BW _+ SD (N) 654.3 + 75.3 661.6 + 73.3 668.0 + 76.4 673.2 + 75.4 674.4 + 77.4 664.5 + 77.6 650.8 + 78.1 656.6 + 82.9 661.9 + 84.7 658.3 + 86.3 660.8 + 81.7 667.7 + 84.9 668.8 + 83.8 670.6 + 85.2 663.1 + 85.5 668.1 + 88.8 675.6 + 86.8 678.9 + 86.4 690.0 + 93.9 686.0 + 91.6 678.3 + 90.3 677.5 + 95.1 675.7 + 98.6 671.1 + 94.4 665.9 + 101.2 642.0 + 99.5 (49) (48) (48) (48) (48) (47) (47) (47) (47) (47) (46) (46) (46) (46) (46) (45) (42) (41) (41) (40) (40) (38) (38) (37) (36) (35) - *577.6 + *583.1 + *587.9 + *590.8 + *593.2 + *596.8 + *598.2 + *604.9 + *608.2 + *608.5 + *601.1 + *605.4 + *604.6 + *611.8 + *610.0 + *617.5 + *617.4 + *614.7 + *624.6 + *621.8 + *627.6 + *621.0 + 627.2 + 625.5 + 629.4 + 613.3 + 69.8 71.2 73.9 75.9 74.9 80.8 80.8 83.0 79.9 76.5 76.5 76.6 77.5 76.7 77.1 79.1 78.8 83.0 87.3 85.6 80.8 84.6 80.8 87.5 88.0 88.1 (48) (48) (48) (48) (48) (48) (48) (48) (48) (46) (46) (46) (46) (46) (46) (46) (46) (46) (45) (45) (45) (45) (45) (44) (44) (44) 30 ppm Mean BW +_ SD (N) 641.9 + 76.9 646.4 + 78.6 652.7 + 78.2 656.8 + 79.5 655.7 + 82.1 658.3 + 84.7 662.5 + 82.0 666.5 + 84.0 666.2 + 86.8 664.4 + 86.3 659.2 + 83.9 663.8 + 86.0 661.7 + 89.3 669.2 + 88.0 666.9 + 87.0 662.3 + 92.6 664.5 + 95.7 654.7 + 102.3 662.4 + 100.5 652.9 + 103.5 660.0 + 86.1 653.4 + 87.0 659.7 + 88.8 660.0 + 94.8 664.0 + 93.2 650.8 + 95.0 (49) (49) (49) (49) (49) (49) (47) (47) (45) (45) (45) (45) (45) (45) (45) (45) (44) (44) (43) (43) (40) (39) (38) (38) (37) (36) -- Number of animals weighed * Significant difference from Control at the 5% level (Dunnett's t Test; a - 0.05) 4)3 COOS01 BEST COPY AVAIiABLE TWO VEAR ORh L ' D*IE T > T O K -O N C STU D V OF R M -3 9 2 4 * F C - 1 4 2 IN R A T S EXP. 4 0281CR0O1 TEC H N IC IA N I N I T I A L S : f'1H 1 'X 'rtV i D A T E : S 4 / 2 1 7 8 1 S E X OF. RA1 S : S MALES - F'uOM NUMBER : S D -3 4 0 WEIGHT OF FU LL FOOD J A R : S 500GRAMS W E E K 01 1R03516 01S FOODJAR 115 1R03517 0S FOODJAR 115 1R03518 01s FOODJAR U S 1R03519 01S FOODJAR U S 1RO3520 01S FOODJAR U S 1R03521 01S FOODJAR U S 1RS3522 0 is FOODJAR U S 1R03523 01S FOODJAR U S 03034 0 is r >j OD JA R U S IF :0 3 5 2 5 6' i S FOOD-J AR U S 1R03526 1S FOODJAR U S 1R83527 01S F OOC'J AF: U S 1R0352S 0 iS FOODJAR U S 1R03529 0 iS F OODJHR U S 1R0S530 01S FOODJAR U S 1R03531 0 is FOODJAR U S 1R03:5 3 2 0 1 S FOODJAR U S 1R03533 01S FOODJAR U S 1R03534 01S FOODJAR U S 1R03535 01S FOODJAR U S 1R03536 01S F"'OD JAR U S *7t~ ; t? 0 1 S FOODJAR U S 1R03533 IS FOODJAR U S 1R0352? IS FOODJAR U S 1RO3540 01S FOOD*J A R 1 1 S 00 3101167. SO 0O7201000. 00 0 0 T '3 0 U S2 . 70 00V4010001. 00 007501157. 00 00 ?601000. 00 0101? 7 01U 7 S . 7 0 0101?80'101010. 00 O 0 7 9 0U 68 . 00 0101010101001. 00 010101157. 40 01012010010. 00 0101301172. SO 010140100101. 00 010501169. 10 010601000. 00 818701143. 00 0110130110610. 00 01101901157. 60 61110101101010. 00 011101159. 40 01120101001. 00 011301157. 60 011401000. 00 011501173. 80 01160101001. 010 011701155. 20 011801000. 00 011901180. 50 01200110001. 10 012101160. 50 012201000. 00 012301163. 10 012401000. 00 012501178. 00 012601000. 00 012701162. 50 012801000. 00 012901162. 80 013001000. 00 0113101156. 90 013201000. 00 013301173. 20 013401000. 00 013501164. 30 013601000. 00 012701165. 10 013801000. 00 0il296'1152. 50 014001000. 00 1 11 1 11 1 11 1 11 1 11 1 11 1 .1 1 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 167. 8 01 162. 7 0 157 0 178. 7 6' 168 0 157. 4 0 172. 9 0 169. 1 0 148 0 157. 6 0 159. 4 0 157. 6 0 173. 8 0 155. 2 0 180. 5 0. 1 160. 5 0 163. 1 0 178 0 162. 5 0 162. 8 8 156. 9 0 173. 2 01 164. 3 0 165. 1 0 152. 5 0 41 4 000802 I K ' . ' j - U O l i 01J.4101117c- 90' ROut ' 1rlF' 1 1 8 0 1 4 2 0 1 0 0 0 . 00! i R'u_ 54 x 0 1 8 01142011X601 10 RDOC' J uR 112 0 14 4 0 1 0 0 0 . 00! 1 K 02542 0 il8 01145011169. 70 FOODJHR' 118 0 1 4601000. 00 I F 02544 018 014701167. 7u L'JHR 118 0114801000. 00 1 K 0 2 5 4 5 0i18 0i14 9 G1 1 6 9. 2 1! ROODJHR 1 1 2 .0150010100. 00 I r : 02 546 0i18 8 1 5 1 8 1 1 4 9 ." "60 FOOL' JHR: 1 1 8 0 1 5 2 0 1 0 0 0 . 00 1R02547 0 1 S 0115201168. 5Q FOO L'J HR 1 1 6 0 1 5 4 0 1 0 0 0 . 00 IF :02 5 4 6 0116 0115501176. 70 F O O t'JH R U S 01156011000. 00 IF: 0|2 54 9 0 1 8 0 1 5 7 0 1 1 7 2 . 00 F O u t'j HR 1 1 6 011`5801100101. 010! 1R O 2 55 0 0116 0159012168. 40 FO O D JH R 112- 01160101101001. 010 1F02551 F OOD J HR IF . 0|2 5 5'2 F 00D JHR 0X6 116 0i1 5 116 016101149. 10 016201101010. 001 0x63:01162. 70 011640110010. 00 1R0255-: 016 0U65011172. 60 FOOD J HR: 1 1 6 0166010010. 0Q IF:02 554 016 016701147 . 20 FOUL' JHR. 1 1 6 011680101001. 00 1F02555 IS 016901154. 30 FOOL1J FlF: I I S 01170011000. 00 1R02556 016 017101168. 60 F UODJRR 1 1 S 017201000. 00 ` *0 3 5 5 ? 016 017301171. 70 j i j O JHF: I I S 0 1 7 4 0 1 0 0 0 . 00. 1R02 558 0 x3 017501174. 90 F O O D Jh R: 1 1 6 017 60110001. 0t! 1R02559 0x6 017701161. 90 FO O D JH R 1 1 6 6il780'100i0'. 0 l R 0 j 5601 0116- 011790i1186-. 50 F O O t'JH R X l2 - 01801011000. 00! 1R02561 0x2. 018x01155. 30 FO O D JH R 1 x 6 0il820il0i0i0. 0i0! 1R:02562 016 0 1 8 2 0 1 1 4 7 . 80 R o o t1JHR: I I S 01X84011000. 00! 1R02562 IS 018501182. 40 F UODJ HR: 1 1 6 01186011000. 00 1R02564 016 0118701144. 50 FOODJHR 116 018801000. 00 1 R 0 2 5 6 5 I S 0 1 8 9 0 1 1 7 4 . 70. FO O D JH R U S 01900100101. 00! 1R02566 016 019101152. 40 FOODJHR: I I S 0 1 9 2 0 1 0 0 0 . 00 1R02567 016 019301162. 20 FOODJHR. U S 0 1 9 4 0 1 00 0 . 00 1R02568 01S 0195011S5. 40 F OODJHR I I S 019601000. 00 1R02569 0 1 S 0U9701157. 70 FOOC'JHR U S 0198010'0i0. 00 R03570 01S 019901162. 60 F |JUt'1JHR. I I S 0 2 0 8 0 1 0 0 0 . 010! IP '01257 1 0 U S 0120101159. 70 FOODJHR: I I S 0120120101010. 00! 1 R 0 2 5 7 2 0 1 S 02013011172. 40 FOOt'JHR 1 1 S 0201401000. 00 1R03572 CHS 020501181. 90 FOODJHR I I S 028681800. 00 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 176. 9 e 168. 1 0 169. 7 0 167. 7 0 169. 3 0 149. 6 0 16S. 5 0 176. 7 0 172 0 160. 4 0 149. 1 162. 7 0 172. 6 0 147. 2 0 154. 2 0 16S. 6 0 171. 7 0 174. 9 0 161. 9 0 186. 5 155. 2 0 147. 8 0 182. 4 0 144. 5 0 174. 7 0 152. 4 0 162. 2 0 185. 4 0 157. 7 8 162. 6 0 159. 7 0 172. 4 0 181. 9 0 bestconAu m ^ 415 C00303 J R 0 - 5 . - I I.1J.2 o 2 ti. O U 77. 2 0 F O D JH k OiOSOXO'OO. 40 1R8I575 X i 02090x165. 80 FOODJHR U S 021001000. 20 1R8I576 0x8 021101160. 20 FUDJHH 1X8 021201000. 00 R2-577 0 x 2 0 2 1 2 8 1 1 7 7 . 20 ODJHR 112 021481000. 00 IROS 578 012 0X1501182. 80 F uO D JmF U S .821681888. 00 IR 02575* O I S 82170114 8 '' 9 FOOD J HR: U S 0 2 1 8 0 1 0 0 0 . >00! 1Ru 2580 012 021901154. 80 FOODJHR U S 022001060. 00 IR:O2 5 s i 0 22 00 >101167. 70 FOOD JHR 1 2 S 08 7281808. 00 1R02582 022 002201160. 70 FOODJHR: 1 2 2 0 0 2*40 1 0 0 8 . 00 1RQ2582 022 00 2501141. 20 FOODJHR: 122 0O 2601000. 0Q 1R02-584 0 2 S 00 2701142. 50 FOOD JHR: 1 2 S 00 2801000. 00 1R02585 022 00 2901159. 40 FOODJHR 122 010O01000. 00 1F.02 5 8 8 0 2 S 0 1 0 x 0 x 1 6 8 . 50 FOODJHR 122 010201800. 0 1R02587 022 010201151. 10 FOODJHR 122 0104010001. 00 1R02-588 0 S 0105 0 1 16 8 . 1Q FOODJHR 1 2 S 018601060. 00 1R02589 02S 0 1 Ci?0 U 4 9 . 10 FOODJHR! 1 2 S 010801101001. 00 02586 0 2 S 0il0'90iU78. 20 FOODJHR 1 2 S 811661660. 00 1R02591 02 S 6 U 1 0 U 5 7 . 20 FO O D JH R 1 2 S 01X1201X0001. 010 1P02502 022 011201156. 70 FO O D JH R 1 2 2 011X *i011010101. 010 I R 0 2 5 8 2 0125 0X15011168. 70 FOODJHR: 1 2 2 011601100101. 00 1 R 0 2 5 9 4 0i22 0 1 1 7 0 1 1 5 8 . 60 FO O D JH R 1 2 S 0111801100101. 00 1R62595 025 011901168. 80 FOODJHR 12S- 0120010010. 00 1R02596 02S 012101172. 90 FOOD JHR: 1 2 S 0122010001. 10 1R02597 02S 012201154. 60 FOODJHR: 1 2 S 012401000. 00 1R02598 02S 012501185. 60 FOODJHR 1 2 S 012601000. 00 1 R 0 2 5 9 8 0 2 S 0 1 2 7 8 1 1 6 6 . 8Gi FOODJHR 1 2 S 612801000. 60 'IR O26O0 6 2 S 0 1 2 9 0 1 1 6 2 . 70 FOODJHR: 1 2 S 0120 0 1 00 0 . 00 1R026O1 6 "S 012101170. 70 FOODJHR 1 2 S 012201008. 00 1P02602 62S 012281151. 10 FOODJHR 125 012401600. 80 _ J2 6 0 2 025' 01 2501168. 20 FO O D JH R 12'S- 0 1 2 6 0 1 0 0 0 . 0 0 1R02604 02S 012701166. 60 FOODJHR 1 2 S 012801000. 00 1R02 605 0 2 S 012-901170. 20 FOOD JHR: 1 2 S 0 1 4 0 0 1 0 0 0 . 0 0 1R02606 022 14101155. 80 F OO DJHR 1 2 S 0 1 4 2 0 1 O 0 0 . 0 1 11 1 11 1 11 1 11 1 11 1 11 1 11 2; 12 12 " 12 2 12 12 2 12 2 12 2 12 X 12 12 2 12 2 12 X 12 2 12 2 12 2 12 2 12 2 12 2 12 X 12 2 12 2 12 y 12 12 2 12 2 .1 2 p jfr JO 0. i " 165. 8 0. 2 160. 2 0 177. 2 0 182. 8 0 149. 9 0 154 0 167. 7 0 160. 7 0 141. 2 0 142. 5 0 159. 4 0 168. 5 0 151. 1 0 168. 1 0 149. 1 0 178. 2 0 157. 2 8 156. 7 0 160. 7 0 158. 6 0 168. 8 0 172. 9 0. 1 154. 6 0 185. 6 0 166. S 0 162. 7 0 178. 7 0 151. 1 8 168. 2 0 166. 6 0 170. 2 0 155. 8 0 wnmm 416 000804 L1-. *:*!' r Hk. jr* u l-lx 0 1160 00 FOOD.) HR i J b O X 114O lo O O . 00 IF: 0x606 o x h L'0 1 x '_"6 80 F' C'OL'J MR l d 0 x4 6 0 1 0 0 0 . 00 1R0L 609 014 70x100. 00 F OuL' J HR 15 5 *3x 4 a 0 1 0 0 o . 00 I R G x-610 014 801171. 50 L' J h R: 153 01 `-'0 0 1 0 O0 . 0 C-! i R'OL 6 11 y 2 5 '.' X Ox o i l Vi' 60 R Out.' J HR Idz -01 O'O'C'x o 00 ...00! I R O .'x x x 1J _ 5 0 x 5 2 0 1 1 6 8 . 40 RUUt'.'HR 1^-. t'xO'4oxO00. 00 IF: Ox 613 y 5 3 0 1 5 5 0 1 1 7 8 . 00 FOOL1j HR' 1 5 5 |01 5 6 0 1 0 0 0 . 00 1 R 03614 02S 0 1 5 7 0 1 1 7 4 . 00. F O O L 'Jh R: 1 5 5 0 1 5 8 0 1 0 0 0 . 0 Q 1R03615 y53 0x5801150. 40 FOOL1JHR: 1 2 5 0 1 6 0 0 1 0 0 0 . 00 1R0Z616 025 01610x156. SO FOOL'JHR: 1 2 S 0 x 6 0 0 1 0 0 0 . 0 Q 1R03617 025 0x600x148. 80 FOOL' JHR: 1 2 5 0 1 6 4 0 X 0 0 0 . 00 IF: Oli 6 1 8 0 2 5 0 1 6 5 0 1 1 5 7 . 50 F 00L' JHR: 125 0 l o o 0 X 0 0 0 . 00 1R03618 025 0x670x150. 70 FOOL'-JHR: 125 0 x 6 8 0 1 0 0 0 . 00 1R0362G 025 016801147. 80 FOOL'JHR: 125 0 1 7 0 0 1 0 0 0 . 00 IR C '2 6 2 1 0 2 5 0 1 7 1 0 x 1 4 3 . 4 0 FOOL'JHR 125 0170 0 1 00 0 . 00 1R03622 025 0173 01146. 80 FOODJhR 125 017401000. 00 ' -:02622 0 2 S 017501168. 10 j OL'.JmR 125 0 1 7 6 0 1 0 0 0 . 00 1 R 0 2 6 2 4 0 2 5 0 1 7 7 0 1 1 4 8 . 60! FOOL' JHR: 1 2 5 0 1 7 8 tj 1 o o O. 00! 1 R 0 2 6 2 5 0 2 5 0 1 7 8 0 1 1 7 7 . 0! FOO L'JHR 1 2 5 OX 8 0 0 x 0 O0. 00! xR :03626 0 2 3 0 1 8 1 O 1 1 8 6 . 50! FOOL'JHR: 125 0 X 6 0 o 1 o 0 O. 10 1R:0_ 6 _ J 025 0 1 6 3 0 1 1 7 5 . 50 FOOL'JHR 125 0164 01000. 00 1R0362S 025 1850X165. 0 FOOL'JHR: 12 5 0 1 8 6 0 1 0 0 0 . 00 1R :03628 0 2 5 0 1 6 7 0 1 1 5 7 . 80! F O u t1JH R 1 2 5 0 1 8 8 0 1 0 0 0 . 00 1F:02620 025 018801170. 70 FOOL'JHR 1 2 S 0180 0 1 00 0 . 00 1R02621 025 018101171. 30 FOODJHR 12S 018001000. 00 1R03622 025 018301160. 40 FOODJHR: 1 2 S 0184 0 1 00 0 . 00 1R03633 02S 018581170. 20 FOODJHR: 125 0 1 8601000. 00 1R03624 625 018701158. 30 F OOC1J HR 1 2 5 0 1 8 8 0 1 0 0 0 . 00 1R03S25 025 018801146. 80 FOOL-JHR 125 000*001000. 00 RG2626 05S 000101168. 00 F OOD J HR: 1 2 5 0 O'0 0 0 1 0 O0. 0 0 1F:03627' 0 2 5 0 0 0 X 0 1 1 7 1 . 00! FOODJHR 125 000401000. 00 1R02628 025 000501X58. 50 FOOL'-JHR 125 0 0 0 6 0 1 0 0 0 . 00 J-Fl0 J S* 0 2 5 0 0 0 7 0 1 1 5 1 . 50! FO O D JH R 1 2 5 0 0 0 8 0 1 0 0 0 HO 2 12 x! 12 2 12 12 x! 12 2 12 2 12 2 12 TV 12 12 d 12 1 12 2 12 TV 12 2 1^12 12 2 12 5 12 2 12 2 12 5 12 2 12 d 12 7* 12 5 12 d 12 Ci. 12 d 12 d 12 2 12 d 12 2 12 d 12 168 0 158. H 0 1 5 0 . Jj. 0 171. er 0 178. s 0 168. 4 0 178 0 174 0 150. 4 0 156. 8 0 148. 8 0 157. 5 0 152. 7 0 147. 9 0 143. 4 0 140. 9 0 169. 1 6 148. 6 0 177. d 0 186. 5 0. 1 175. 5 0 1 6 5 . C"mV 0 157. 8 0 172. 7 0 171. 2 0 160. 4 0 172. 2 0 158. 3 0 146. 9 0 169 0 171 0 159. 5 0 151. 5 0 s% li 417 000805 J--Z' ijw\j__*Ftx1 4 & 2 0. FOOL' .tni- Ik'Z' 6.: J.0 O 1 0 U 0 . 00 1R02 64 i. 02'x- 0 8 1 1 0 1 1 6 8 . 70 FOOL' JHK 1 2 0 8 1 8 0 1 0 0 0 - 01! IF: *33-642 0 2 2 0 2 1 2 0 1 1 6 7 . 20 FOOC'JHR 128 0 2 1 4 0 1 0 0 0 . 10 ' R*31 642 02 z- 0*215*31155. 6 0 00DJHR 22S 0x16 010O0. 00 1R02644 022 021701171. 60 FO O D JH R 1 _ .' 2 1 6 0 1 0 0 0 . 00 IR O jF -ts 022 021:601151.' 60 FOOL1JHR 1 2 0 2 2 0 0 1 0 0 0 . 00 1R0X ii4t' 02 S 0 2 81 0 1 14 6 . 70 FOOC'JHR 13 i 0 2 2 2 0 1 00 0 . 00 1R82647 02S 088301180. 20 FOOD J h R 12 2 0 2 2 4 0 1 0 0 0 . 00! 1R02648 02 S 0223 0 1 16 7 . 40 FOOD J h R 13 S' 0888010100. 00! 1 R 0 2 6 4 9 03 S 0 2 2 7 0 1 1 6 5 . 20! F O O L 'Jh R 13 S. 0 2 2 8 0 1 0 0 0 . 0Q IRC*3 6 5 0 2 S 0 2 2 9 0 1 1 6 7 . 40 Fu uD J h R 13 012'00 1 0 0. 0 Q 1RW2-65X 02 2 0 2 2 1 0 1 1 4 8 . 20! FOOL' JflR 13 S 0 x 2 2 O2 O0 . 00 1R03 6 0^ 02 2 022 2*2*1178. 50 F O O D Jh R 13 022401*300. 0*0! 1 R 0 j - 5 x 02 2 0 2 2 5 0 1 1 6 2 . 50! F O O D JflR 13 S 0 2 2 6 0 1 0 0 0 . 00! 1 R 0 2 6 5 4 02-2 0 2 2 7 0 1 1 7 0 . 60 F OOD J h R 12 2 022801O ' Oi0. 00! 1R02655 022 082961166. 50 FOOD JH R 13 S 0240*31000. 00! :3656 025 0241*31164. 10 R O O D Jh R 1 2 2 01842*31*360. 00! 1R 02 6 5 7 022 024x.0;l:i.6-4. 50 FOOC'JH R 12- 2 0*24401000. 00; 1 R 0 3 d OS 02 2 *324 5131156. 90! FO O D JH R 12-2 0*24 6 0 1 0 3 0 . 00! 1 R 0 2 6 5 9 02 `z 024 7 0 1 1 8 0 . 20! FO O D JhR 1_. 0124801000. 00 IF.'02 660 02 2 024 9 0 1 1 5 6 . 40 FOOD JHR 13 025*301*333. *30! 1R02661 02 2 0 2 5 1 0 1 17 5 . 70 FOOD J h R 1 2 0 2 5 2 0 1 3 3 3 . 00! 1 R 0 3 6 6 2 62 2 *323201161. *30 F O O C 'Jh R 1 3 *325401000. 00! 1R02662 63 FOOC'JH R 12 0125601000. *3Q JLR02-664 02 2- 0257*31162. 80 F O O D JflR 13 0*2`5 8 0 1 0 0 0 . 00! 1R02665 03 025901176. 50 FOODJHR 13 Oi26Oi01000. 0Q 1R:03666 0 2 S 0 2 6 1 0 1 1 8 7 . 40! FO O D JH R 1 2 S 0 2 6 2 0 1 0 0 0 . 00! 1R03-667 0 2 S 0263011165. 10! FOODJflR 12 02 64 0 1 30 0 . 0Q IF: 03 c-OS 02 2 8 2 6 5 3 1 1 5 7 . 80! F ` ODJHR: 1 2 02660*1000. 00! *-t .J j-6 6 3 2-S 0 2 6 7 3 1 1 5 3 . 8 0 FOOC'JHR 12 0 2 6 8 0 1 8 3 0 . *30! 1 R 0 2 6 7 0 02-2 0 2 6 -9 0 1 1 7 1 . 00! FOOC'JHR 1 2 0 2 7 0 1 0 0 0 . 00! 1 R 3 2 6 7 1 02 2 0 2 7 1 0 1 1 6 8 . 50! FOODJHR 1 2 S *327201000. 0Q 1 R 0 2 67 2 0 2 2 01272.0*1174. 60 F O O D JflR 1 2 6*274*31*300. 10 2 8 2 12 CL 12 y 12 2 12 2 12 X12 X12 X13 X13 12 X12 X12 2 12 X12 12 *<; 12 X12 X' 12 X12 x 12 X' 12 s 12 12 2 12 13 12 13 X! 12 x13 x 12 13 3 13 BEST COPY AVAll ABLE 146. 2 0 166. 7 U 167. 2 0. 1 155. 6 171. 8 0 151. 6 0 149. 7 0 18*3. 2 0 167. 4 0 165. 2 0 167. 4 0 148. 2 0 178. 5 0 162. 5 0 170. 6 0 166. 5 0 164. 1 0 164. 5 0 156. 9 0 180*. 2 0 156. 4 0 175. 7 0 161 0 171. 2 0 162. 8 0 176. 5 0 187. 4 0 165. 1 0 157. 8 0 15-2. 8 0 171 0 168. 5 0 174. 6 0. 1 418 000806 K S T COPY AVAU 48L E -LP *i< K.->_ Rl_ '.'27 3 0 1 1 3 3 . 30 F O 'JD J mR i _ X '0 ,, , 5010100 0 0. 1R`0CG rh G - 6 2 , 7 0 1 1 3 2 . 30 FOOL* JFiF 122 jXr X 0 1 0 0 0 . 0Q iR u i 0 " 5 Ci5 V*5 0 1 1 6 5. 5 Cl FOOD .'RR 1 3 3 0 2 3 0 0 1 0 0 0 . 00 1R02 5 i"t* Oli 5 0 2 3 1 0 1 1 7 3 . 40 tL'JFiR 12 5 0 5 5 5 0 1 0 G O. O0. -Lr>J^- F r r 0 55 0 2 3 2 0 1 1 ?' 2. 50 FOOD'J MR 1 22 0 2 340100CI. 00 1 R 0 2 6 7 8 02 S 0 2 3 5 0 1 1 7 1 . 30 F O O D J RR: 12-S 02'3601000. 00 1 R 0 2 6 7 9 O2 S 0 2 3 7 0 1 5 3 . 6Gi FOODJRR: 12 3 023:301000. 00 IF: G'2 6 3 0 02 5 02:33101144. 40 F O O D JR R x i 5 Cix 5 0 OX C'i0 0. 0 Q 1R 02631 02 S 0 2 3 1 0 1 17 2 . 3Q F OOC* jMK 1 2 3 0 2 5 5 0 1 0 0 0 . OQ 1R62 633 02 5 0 2 3 2 0 1 16 3 . 30 FO OD J RF: 1 2 5 0 2 3 4 0 1 0 0 0 . 10 1 F Ci2 632 0 2 3 0 2 3 5 0 1 1 5 3 . 80 FOODJR 12 S 023601000. 00 1R02684 62 S 0 2 3 7 0 1 1 6 8 . 70 F 0 CiL1J h F 1 3 3 0 2 3 6 0 1 0 0 0 . 00 1R 36S5 02 S 0233 0 1 17 8 . 40 FOOL' J MH 12 3 0 2 0 0 0 1 0 0 0 . 00 lR 056b5 025 020101153. 30 FOOD .THF 1 2 3 0 5 0 x 0 1 0 0 0 . OC-! 1 F:02 68 7 02 5 t'3 02 0 x 1 7 1 . 40 F OOD J MR: 1 _ 3 0 2 0 4 0 1 0 0 0 . 00 1 R 0 2 6 8 3 02 2' 0 2 0 5 0 1 1 7 4 . 40 FOOD J FtF 1 2 3 0 2 0 1-0 1 0 0 0 . 0 F C' 2 6 33 02-5 0 2 0 7 0 1 1 6 4 . 30 JO L'JR F 12 5 0 2 0 8 0 1 0 0 0 . 0 0 1R Q 2 69 0 02-5 03 0 3 0 1 1 5 6 . 20 FOODJRR 133 1021001000. 00 1R 2691 02 5 0 2 1 1 0 1 1 7 2 . 50 FOOD JRR 123 021201000. 00 1R02 63*; 0 2 3 0 2 1 3 0 1 1 6 0 . 10 FOODJRR 123 02140 1 00 0 . 0Q 1 R 0 2 6 3 2 02-S 0 2 1 5 0 1 1 6 1 . 70 FOODJRR 133 0316.01000. 00 1R02694 02S 021701176. 30 FOODJRR 123 021801000. 00 1R03635 025 031301177. 50 FOODJftR 133 022001000. 00 U`M Q C| Q Q *'-4'-JCi Q C| 212 J;. 12 2 12 5 12 J. 12 J*. 13 12 X 13 5 12 X 12 X 12 13 13 s 12 212 X 12 J. 12 12 X 13 X 13 X12 X13 2 12 0 185. 5 0 152. 3 O 155. 5 0 173. 4 0 172. 5 0 171. 8 0 159. 6 0 144. 4 0 172. 2 0 169. 3 0. 1 152. 8 0 168. 7 0 178. 4 0 153. 3 0 171. 4 0 174. 4 0 164. 3 0 156. 2 0 172. 5 0 160. 1 0 161. 7 0 176. 3 0 177. 5 0 4 9 000807 BEST COPY AVAILABLE TWO VEftR O R A L D IE T > TOX-ONC STUDY OF FM -3924 & FC -143 IN RATS EXP. # 0261CR0012 TECHNICIAN IN IT IA L S S MH TODAY'S DATE: S 4 /2 8 /8 1 SEX OF RATS: S MALE ROOM NUMBER:S D -3 4 0 WEIGHT OF FULL FOOD JA R : S 500GRAMS WEEK 1 1R03516 01S 010000218. 7Q FOODJAR U S 010100338. 90 1R03517 01S 010200216. 6Q FOODJAR U S 010300349. 1G 1R03518 01S 010400211. IQ FOODJAR 11 s 010500345. 4Q 1R03519 01S 010600234. 6Q FOODJAR 11S 010700324. 60 1R03520 01S 010800220. 60 FOODJAR 11S 010900339. 60 1R03521 01S 011000204. 9Q FOODJAR 11S 011100254. 70 1R02522 01S 011200219. 8Q FOODJAR 11S 011300341. 00 1R03523 01S 011400214. 50 FOODJAR 11S 011500358. 2Q 1P.03524 01S 011600199. 6Q FOODJAR 11S 011700364. 70 .03525 01S 011800206. 80 FOODJAR 11S 011900359. 80 1R03526 01S 012000207. 40 FOODJAR 11S 012100341. 00 1R03527 01S 012200215. 10 FOODJAR IIS 012300344. 90 1R03528 01S 012480226. 40 FOODJAR U S 012500339. 10 1R03529 01S 012600213. 10 FOODJAR 11S 012700338. 8Q 1R03530 01S 012800230. 0Q FOODJAR 11S 012900344. 90 1R03531 01S 013000211. 40 FOODJAR 11S 013100348. 20 1R03532 01S 013200215. 7Q FOODJAR U S 013300342. 2Q 1R03533 01S 013400234. 6Q FOODJAR 11S 013500325. 4Q 1R03534 01S 013600215. 9Q FOODJAR 11S 013700344. 3Q 1R03535 01S 013800198. 5Q FOODJAR U S 013900369. 40 1R03536 01S 014000197N0Q FOODJAR 11S 014100362. IQ 1R03537 01S 014200226. 20 ODJAR 11S 014300342. 90 .83538 01S 014400220. 9Q FOODJAR 11S 014500340. 00 1R03539 01S 014600210. 40 FOODJAR 11S 014700355. 5Q 1R03540 01S 014800203. 10 FOODJAR 11S 014900352. 7Q 1R03541 01S 015000227. 30 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 218. 7 338. 9 216. 6 349. 1 211. 1 345. 4 234. 6 324. 6 220. 6 339. 6 204. 9 354. 7 219. 8 341 214. 5- 358. 2 199. 6 364. 7 206. 8 359. 8 207. 4 341 215. 1 344. 9 226. 4 339. 1 213. 1 338. 8 230 344. 9 211. 4 348. 2 215. 7 342. 2 234. 6 325. 4 215. 9 344. 3 198. 5 369. 4 197 362. 1 226. 2 342. 9 220. 9 340 210. 4 355. 5 203. 1 352. 7 227. 3 G00808 FOODJRR U S 015100348. 4Q 1R03542 01S 015200215. 50. FOODJRR U S 015300335. 80 1R03543 01S 015400223. 60 FOODJRR U S 015500320. #0 1R03544 01S 0156-00216. 80 FOODJRR U S 015700340. 90 03545 01S 015800220. 10 FOODJRR U S 015900348 00 1R03546 01S 016000207. 40 FOODJRR U S 016100245. 60 1R03547 01S 016200222. 00 FOODJRR U S 016380229. 90 1R0354S 01S 016400235. 00 FOODJRR U S 016500336. 4Q 1R03549 01S 016608223. 30 FOODJRR U S 016700252. 70 1R0355O 01S 016800219. 4Q FOODJRR U S 016900250. 00 1R03551 01S 017000183. 2Q FOODJRR U S 017100374. 2Q 1R03552 01S 017200216. 10 FOODJRR U S 017200336. 9Q 1R02553 01S 017400228. 3Q FOODJRR U S 017500234. 7Q 1R02554 01S 017600192. 60 FOODJRR U S 017700257. 40 1R02555 01S 017800204. 8Q FOODJRR U S 017900254. 4Q 1R03556 01S 018000226. 6Q FOODJRR U S 018100339. IQ 1R03557 01S 018200233. 2Q "ODJRR U S 018300334. 8Q -.<02558 eis 018400217. 7Q FOODJRR U S 018500351. IQ 1R03559 01S 018600218. 70 F O O D JRR11S 1R02560 01S 018800234. IQ FOODJRR U S 0189 0246. 90 1R03561 01S 19000212. 60 FOODJRR U S 019100338. 0Q 1R02562 01S 019200192. 6Q FOODJRR U S 019300270. 0Q 1R02563 01S 019400237. 6Q FOODJRR U S 019500238. 7Q 1R83564 01S 019600197. 8Q FOODJRR U S 019700362. 5Q 1R03565 01S 019800227. IQ FOODJRR U S 019900351. IQ 1R03566 01S 020000205. 3Q FOODJRR U S 020100356. 8Q 1R03567 01S 020200221. 30 FOODJRR U S 020300340. 8Q 1R02568 01S 020400247. IQ FOODJRR U S 020500228. 7Q 1R03569 01S 020600219. 90 FOODJRR U S 020700245. 80 * R03570 01S 020800218. 0Q lODJRR U S 020900320. 6Q 1R83571 01S 021000217. 8Q FOODJRR U S 021100336. 8Q 1R03572 01S 0212O0219. 3Q FOODJRR U S 021300345. 0Q 1R03572 01S 021400234. 2Q FOODJRR U S 021500334. 9Q 1R03574 01S 021600237. 4Q 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 348. 4 PYAVAILABLE 215. 5 335. e 223. 6 330 216. 8 340. 9 230. 1 348 207. 4 345. 6 222 329. 9 235 336. 4 223. 3 352. 7 219. 4 350 183. 2 374. 2 216. 1 336. 9 228. 3 334. 7 192. 6 357. 4 204. 8 354. 4 226. 6- 339. 1 233. 2 334. 8 217. 7 351. 1 218. 7 339.5 234. 1 ` 346. 9 212. 6 338 192. 6 370 237. 6 338. 7 197. 8 362. 5 227. 1 351. 1 205. 3 356. 8 221. 3 340. 8 247. 1 328. 7 219. 9 345. 8 218 320. 6 217. 8 BEST COPY AVAILABLE 336. 8 219. 3 345 234. 2 334. 9 237. 4 eooso 1 FOODJftR U S 021700326. 06 1R03575 01S 021880216. 4Q FOODJftR U S 021900340. 46 1R03576 01S 0220O0211. 86 FOODJflR 11S 022100342. 16 1R63577 01S 022200222. 46 FOODJftR 11S 022300327. 76 "`03578 01S 022400226. 0Q ,.JODJflft U S 022500330. 06 1R0357S* eis 022600204. 00 FOODJftR n s 022700357. 06 1R0358O 01S 022800202. 86 FOODJftR IIS 022900351. 3Q 1R03581 02S 007100206. 46 FOODJftR 12S 007200360. 56 1R035S2 02S 007300204. 9Q FOODJftR 12S 007400368. 16 1R03583 02S 00 7500160. 9Q FOODJftR 12S 007600388. 26 1R03584 02S 007700188. 8Q FOODJftR 12S 007800360. 86 1R03585 82S 007900189. 76 FOODJftR 12S 010000355. 16 1R03586 02S 010100202. 80 FOODJftR 12S 010200358. 36 1R03587 02S 010200171. 66 FOODJftR 12S 010400399. 0Q 1 R 0 3 5 8 S 02S 010500202. 76 FOODJflR 12S 010600390. 9Q 1R03589 02S 010700181. 16 FOODJftR 12S 010800365. 26 1R03590 02S 010900223. 06 FOODJftR 12S 011000348. 50 03581 02S 011100174. 26 FOODJflR 12S 011200384. 70 1R03592 02S 011300195. 50 FOODJftR 12S 011400363. 70 1R03593 02S 011500187. 2Q FOODJftR 12S 011600388. 30 1R03594 02S 011700200. 26 FOODJftR 12S 011800343. 20 1R03595 02S 011900192. 3Q FOODJftR 12S 012000380. 50 1R03596 02S 012100180. 9Q FOODJftR 12S 012200390. 0Q 1R03597 02S 012300199. 0Q FOODJftR 12S 012400366. 5Q 1R03598 02S 012500227. 66 FOODJflR 12S 012600365. 7Q 1R03599 02S 012700175. 3Q FOODJflR 12S 012800377. IQ 1R03600 02S 012900170. 70 FOODJflR 12S 013000396. 2Q 1R03601 02S 013100211. 5Q FOODJflR 12S 013200351. 7Q 1R03602 02S 013300184. 0Q FOODJflR 12S 013400374. 20 1R03603 02S 013500210. 5Q ' ODJflR 12S 013600361. 4Q .*..03604 02S 013700184. 3Q FOODJftR 12S 013800378. 50 1R03605 02S 01390020!. 30 FOODJftR 12S 014000363. 80 1R03606 02S 014100188. 0Q FOODJflR 12S 01420O366. 50 1R03607 02S 014300216. 5Q 11 1 11 1 11 1 11 1 11 1 11 1 11 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 326 216. 4 340. 4 211. 8 342. 1 232. 4 337. 7 226 330 204 357 202. 8 351. 3 206. 4 360. 5 204. 9 368. 1 160. 9 388. 2 188. 8 360. 8 189. 7 355. 1 202. 8 358. 3 171. 6 399 202. 7 390. 9 181. 1. 365. 2 223 348. 5 174. 2 384. 7 195. 5 363. 7 187. 2 388. 3 200. 2 343. 2 192. 3 380. 5 180. 9 390 199 366. 5 227. 6 365. 7 175. 3 377. 1 170. 7 396. 2 211. 5 351. 7 184 374. 210. 2 5 BEST COPY AVAILABLE 361. 4 184. 3 378. 5 20 363. 8 188 366. 5 216. 5 422 000810 FOOD-JAR 12S 014400355. 60 1R03608 02S 014500199 00 FOODJAR 12S 014600349. 30 1R03609 02S 014780186. 30 FOODJAR 12S 014800355. 50 1R03610 02S 814900226. 90 FOODJAR 12S 015000350. 40 33611 02S 015100210. 3G FOODJAR 12S 015200371. 60 1R03612 02S '015300206- 00 FOODJAR 12S G15400359. 00 1R03613 02S 015500220. 7Q FOODJAR 12C 12 1R03614 02S015600208. 3Q FOODJAR 12S 015700334. 0Q 1R02615 02S 015800194. 70 FOODJAR 12S 015900349. 6Q 1R03616 02S 016000191. 00 FOODJAR 12S 016100362. 30 1R03617 02S 016200187. 4Q FOODJAR 12S 016300364. 30 1R03618 02S 016400195. 10 FOODJAR 12S 016500354. 5Q 1R03619 02S 016600177. IQ FOODJAR 12S 016700370. 40 1R03620 02S 016800184. 90 FOODJAR 12S 016900357. 80 1R03621 02S 017000163. IQ FOODJAR 12S 017100400. 4Q 1R03622 02S 017200176. 3Q FOODJAR 12S 017300385. 7Q '03623 02S 017400200. 80 ,JODJAR 12S 017500356. 90 1R03624 02S 017600174. 80 FOODJAR 12S 017700372. 60 1R03625 02S 017800185. 80 FOODJAR 12S 017900375. 40 1B03626 02S 018000218. 8Q FOODJAR 12S 018100374. 10 1R03627 02S 018200221. 7Q FOODJAR 12S 018300359. 5Q 1R0362S 02S 018400203. 7Q FOODJAR 12S 018500362. 00 1R03629 02S 018600193. IQ FOODJAR 12S 018700366. 3Q 1R03630 02S 018800178. 9G FOODJAR 12S 018900407. 20 1R03631 02S 019000211. 9Q FOODJAR 12S 019100349. 9Q 1R03632 02S 019200197. 6Q FOODJAR 12S 019300361. 9Q 1R03633 02S 019400200. 8Q FOODJAR 12S 019500373. 6Q 1R03634 02S 019600158. 7Q FOODJAR 12S 019700388. 90 1R03635 02S 019800162. IQ FOODJAR 12S 019900391. 7Q :03636 02S 020000197. 3Q FOODJAR 12S 820100369. 5Q 1R03637 02S 020200195. 9Q FOODJAR 12S 020300359. 2Q 1R03638 02S 020400186. 3Q FOODJAR 12S 020500358. 7Q 1R03639 02S 020600180. 7Q FOODJAR 12S 020700368. 2Q 12 2 12 2 12 2 12 2 12 ' 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 '2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 355. 6 199 349. 3 186. 3 355. 5 226. 9 350. 4 210. 3 371. 6 206 359 220. 7 350.-4 208.:3 334 194. 7 349. 6 191 362. 3 187. 4 364. 3 195. 1 354. 5 177. 1 370. 4 184. 9 357. 8 163. 1 400. 4176. 3 385. 7 200. 8 356. 9 174. 8 372. 6 185. 8 - 375. 4 218. 8 374. 1 221. 7 359. 5 203. 7 362 193. 1 366. 3 178. 9 407. 2 211. 9 349. 9 197. 6 361. 9 200. 8 373. 6 158. 7 388. 9 162. 1 391. 7 197. 3 369. 5 195. 9 359. 2 186. 3 358. 7 180. 7 368. 2 J s COPY AVAILABLE 423 000811 1R03648 02S 020800158. IQ FOOD.IftF: 128 020900396. 8Q 1F:03641 02S 021000201. 3Q FOODJfiR 12S 021100365. 8Q 1RQ3642 02S 021200174. 8Q FOODJfiR 12S 021300293. 26 1R03643 02S 021400188. 8Q ODJfiR 12S 021500377. 46 _.-i03644 02S 021600189. 26 FOODJftR 12S 021700374. 16 1R03645 02S 021800187. 26 FOODJftR 12S 021900362. 46 1R03646 03'S 022000198. 46 FOODJftR 128 022100353. 36 1R03647 02S 022200228. 16 FOODJftR 12S 022300336. 76 1R03648 02S 022400226. 26 FOODJftR 12S 022500326. 3Q 1R03649 03S 022600212. 26 FOODJfiR 13S 022700346. 16 1R03650 03S 022800214. 96 FOODJftR 13S 022900349. IQ 1R03651 02S 023000208. 0Q FOODJfiR 13S 023100344. 7Q 1R03652 02S 023200224. 46 FOODJftR 12S 023300345. 06 1R03653 02S 023400221. 66 FOODJftR 12S 023500336. 66 1R03654 03S 023600222. 48 FOODJfiR 138 023700340. 96 1R03655 03S 023800221. 9Q FOODJFIR 13S 023900334. 4Q dR03656 02S 024000219. 76 ODJfiR 12S 024100328. 56 1R03657 03S 024200218. 56 FOODJftR 12S 024300349. 16 1R03658 02S 024400210. 96 FOODJftR 12S 024500340. 86 1R02659 02S 024600237. 96 FOODJftR 13S 024700330. 0Q 1R03660 02S 824800207. 2Q FOODJftR 13S 024900352. 2Q 1R03661 03S 025000225. 7Q FOODJftR 12S 025100343. 6Q 1R03662 03S 025200283. 8Q FOODJfiR 12S 025300357. 8Q 1R03663 038 025400233. 36 FOODJftR 13S 025500323. 86 1R03664 03S 025600219. 26 FOODJfiR 13S 025700337. 6Q 1R03665 03S 025800230. 66 FOODJfiR 13S 025900337. 46 1R03666 03S 026000243. 7Q FOODJfiR 13S 026100323. 5Q 1R03667 03S 026200206. 76 FOODJfiR 13S 026300358. 6Q 1R03668 03S 026400198. 4Q FOODJfiR 12S 026500361. 56 03669 03S 026600212. 0Q . -ODJfiR 13S 026708334. 7Q 1R03670 03S 026800227. 8Q FOODJftR 13S 026900333. IQ 1R03671 02S 027000221. 56 FOODJfiR 12S 027100345. 06 1R03672 03S 027200231. 6Q FOODJfiR 12S 027300326. 3Q 2 12 2 12 2 12 2 12 2 12 2 12 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 "3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 158. 1 296 8 201. 3 265. 8 174. 8 293. 2 188. 8 377. 4 189. 2 374. 1 187. 2 362. 4 198. 4 353. 3 238. 1 336. 7 226. 2 326. 3 213. 2 346. 1 214. 9 349. 1 208 344. 7 224. 4 345 221. 6 336. 6 222. 4 340. 9221. 9 334. 4 219. 7 328. 5 218. 5 349. 1 210. 9 340 237. 9 330 207. 2 352. 2 225. 7 343. 6 203. 8 357. 8 233. 3 323. 8 219. 2 337. 6 230. 6 337. 4 243. 7 323. 5 206. 7 358. 6 198. 4 r BEST COPY AVAILABLE 227. 8 333. 1 221. 5 345 231. 8 326. 3 00081422 4 1R0367j: 02S .037400230 40 FOOD,THF! 13S 027500342.' 10 1R02674 03027600202. 3C:ic. FOODJRR 13 S 027700341. 70 1R03675 03 S 027880225. 30 F'XiDJRR l"?^ 027900333. IQ 03676 03S 028000244. 00 FOODJRR 13 S 028100324. 50 1R03677 03S 028200229. 3Q FOODJFlR 13 S 028300327. 50 1R03678 03 S 028400227. 9Q FOODJFlR 13 S 028500335. 4Q 1R03679 03S 028600216. 40 FOODJRR 13S 028700332. 40 1R036S0 03S 028800204. 50 FOODJRR 13S 028900337. 20 1R036S1 03S 029008231. 80 FOODJRR 12S 0291003-30. 80 1R03682 03S 029200216. 00 FOODJRR 13S 029300353. 60 1R036S3 03S 029400206. 80 FOODJRR 13S 029500350. 00 1R03684 03S 029600222. 7Q FOODJRR l^c; 029700339. 7Q 1R02685 03S 029800227. 6Q FOODJRR 13S 029900350. 10 1R03686 03S 030000288. 40 FOODJRR 17c. 030100345. 9Q 1R03687 03S 030200229. 90 FOODJRR 13S 030300330. 9Q 1R03688 03 030400230. 00 ODJRR 13S 030500337. 50 u.,<03689 03S 030600211. 9Q FOODJRR 13S 030700349. 2Q 1R03690 02S 030800214. 50 FOODJRR 13S 030900338. 6Q 1R03691 03S 031000223. 40 FOODJRR 13S 031100345. 30 1R03692 03S 031200212. 00 FOODJRR 13S 031300348. 1G 1R03692 03S 031400223. 4Q FOODJRR 13S 031500328. 9Q 1R03694 03S 031600234. 9Q FOODJRR 13S 031700334. 4Q 1R03695 03S 031800236. 4Q FOODJRR 13S 031900320. 20 9999999999 99 3 13 3 12 3 12 3 13 3 13 3 13 3 13 3 12 2 13 2 12 3 13 3 12 3 13 2 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 12 3 13 0 238. 4 342. 1 203..3 341. 7 225. 3 333. 1 244 324. 5 229. 3 327. 5 227. 9 225. 4 216. 4 232. 4 204. 5 337. 2 231. 8 220. 8 216 353. 6206. 8 350 222. 7 339. 7 227. 6 350. 1 208. 4 345. 9 ' 229. 9 330. 9 230 337. 5 211. 9 349. 2 214. 5 328. 6 223. 4 345. 3 212 348. 1 223. 4 328. 9 234. 9 234. 4 236. 4 320. 2 BEST COPY AVAILABLE 425 000813 TWO YEAR O R A L <DIET) TOX-ONC STUDY OF FM-3924 , FC-143 IN ROTS EXP. # 0281CR0012 TECHNICIAN INITIALS:S MH TODAY'S D A T E :S 5/5/81 SEX OF R A T S :S MALE ROOM NUMBER.S 0-240/0-228 WEIGHT OF FULL FOOD J A R :S 500GRAMS WEEK 2 1R03516 01S 007100284. 0Q FOODJAR 11S 007200332. 60 1R03517 01S 007300270. 00 FOODJAR IIS 007400341. 50 1R0251S 01S .07500267. 60 FOODJAR 11S 007600342. 00 1R03519 01S .7700293. 7Q FOODJAR 11S 007800325. 2Q 1RO3520 01S 0079. 0280. 60 FOODJAR. 11S 010000322. 30 1R03521 01S 010100255. 60 FOODJAR IIS 010200249. 90 1R03522 01S 010308273. 60 FOODJAR 11S 010400338. 60 1R03522 01S .10500281. 90 FOODJAR 11S 010600346. 4Q 1R03524 01S 018700250. 2Q POODJAR IIS 010800362. 7Q .02525 01S 010900258. 50 FOODJAR 11S 011000352. 00 1R03526 01S 011100268. 20 FOODJAR U S 011200329. 6Q 1R03527 01S 011/00266, 20 FOODJAR 11S 011400345. 2Q 1R03528 IS .11500276. 60 FOODJAR IIS 011600337. 0Q 1R03529 G1S 011700266. 80 FOODJAR IIS 011800312. 5Q 1R03520 01S 011900290. 3Q FOODJAR 11S 012000339. 7Q 1R03531 01S 012100268. 80 FOODJAR 11S 012200336. 9Q 1R03532 01S 012/00271. 00 FOODJAR 11S 012400337. 5Q 1R02533 01S .12500294. 50 FOODJAR 11S 012600320. 6Q 1R03524 01S 012700284. 6Q FOODJAR 11S 012800327. 40 1R02535 eis 012900244. 6Q FOODJAR 11S 013000362. 5Q 1R02536 01S 813100250. 50 FOODJAR U S 013200356. 60 1R03537 01S 013300266. 5Q ODJAR IIS 013400338. 4Q XK03538 01S 013500283. 00 FOODJAR 11S 013600332. IQ 1R03539 01S 013780247. 50 FOODJAR 11S 013808358. 6Q 1R03540 01S .13900249. 2Q FOODJAR 11S 014000344. 80 1R03541 01S 014100286. 3Q 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 .11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 284 232. 6 270 341. 5 267. 6 242 293. 7 325. 3 280. 6 332. 3 ' 255. 6 249. 9 273. 6 338. 6 281. 9 346. 4' 250. 2 362. 7 258. 5 352 268. 2 229. 6 266 245. 2 276. 6 337 266. 8 312. 5 290. 2 239. 7 268. 8 336. 9 271 237. 5 294. 5 320. 6 284. 6 327. 4 244. 6 362. 5 250. 5 356. 6 266. 5 i ; BEST COPY AVAILABLE 247. 5 358. 6 249. 2 344. 8 286. 3 426 000814 FOODJRR 118 014200339. 50 1R03542 eis 014300274. 80 FOODJRR 118 0144O0331. 30 1R03543 01S 014500290 40 FOODJRR 118 014600316. 20 1R03544 01S 0147. 0275. 60 FOODJRR IIS 014300330. 50 03545 01S 014900286. 30 F-OOD JRR 118 015000330. 90 1R03546 01S .015100269. 60 FOODJRR 11 015200337. 40 1R03547 01S 015300266. 60 FOODJRR 118 815400321. 00 1R03548 IS 015500300. 40 FOODJRR 118 015600327. 40 1R03549 018 .15700270. 60 FOODJRR! 118 015800354. 60 1R03550 01S 015900278. 60 FOOD'JRR! 118 016000345. 70 1R83551 018 016100216. 00 FOODJRR 118 016200375. 90 1R03552 018 016300275. 60 FOODJRR 118 016400320. 60 1R03553 018 016500289. 60 FOODJRR: 118 016600326. 60 1R03554 01S 016700239. 70 FOOD1JRR: 118 0068003:51. 50 1R03555 018 .16900255. 70 FOODJRR 118 017000351. 80 1R03556 018 017100264. 3Q FOODJRR 118 017200320. 30 1R03557 018 017300287. 00 '"-IODJRR 118 017400336. 10 . .03558 018 .17500252. 00 FOODJRR 118 017600359. 10 1R03559 018 017700280. 10 FOODJRR: 118 017800342. IQ 1R03560 01S 017900278. 70 FOODJRR 118 013000350. 10 1R03561 018 .18100287. 70 FOODJRR 118 018200316. IQ 1R03562 018 .18300239. 90 FOODJRR 118 018400360. 2Q 1R03563 018 018500284. 60 FOODJRR 118 018608337. 80 1R03564 018 018700243. 80 FOODJRR 118 018800358. 40 1R03565 01S 018900280. 6Q FOODJRR 11S 019000341. 80 1R03566 01S 019100263. 9Q FOODJRR 11S 019200338. 7Q 1R03567 01S 019306280. 50 FOODJRR U S 019400337. 3Q 1R03568 018 019500303. 70 FOODJRR IIS 019600330. 2Q 1R03569 01S .19700277. 7Q FOODJRR 118 019800336. 50 1R03570 018 019900266. 7Q ODJRR 118 020000317. 70 1R03571 018 020100283. 70 FOODJRR 118 020200320. 90 1R03572 01S 020300268. 4Q FOODJRR 118 820400342. 80 1R03573 018 .20500291. 30 FOODJRR 11S 020600334. 70 1R02574 01S .20700265. 4Q 11 1 11 1 11 1 11 1 11 . 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 '11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 339 5 274. 8 331. j: 290. 4 316. 2 275. 6 330. 5 286. 3 330. 9 269. 6 337. 4 266. 6 321 300. 4 327. 4 270. 6 354. 6 270. 6 345. 7 216 375. 9 275. 6 320. 6 289. 6 326. 6 239. 7 351. 5 255. 7 351. 8 264. 3 320. 3 287 336. 1 252 359. 1 280. 1 342. 1 278. 7 350. 1 287. 7 316. 1 239. 9 360. 2 284. 6 337. 8 243. 8 358. 4 280. 6 341. 8 263. 9 338. 7 280. 5 337. 3 303. 7 330. 2 277. 7 336. 5 266. 7 317. 7 283. 7 320. 9 268. 4 342. 8 291. 3 334. 7 265. 4 BEST COPY AVAILABLE 427 000815 FOODJflR 1 1 020800315 10 1R03575 01S .0900263. 30 FOODJflR l i s 021000339. 40 1R03576 018 .21180268. 40 FOODJflR 118 021208340. 00 1R03577 01S 021200283. 80 FOODJflR l i s 021400330. 6Q i35 7*S 01S 021500261. 60 r o D J h R l i s 021600350. 10 1P02579 ers .021700258. 80 FOODJflR 11S 021800344.' 10 1R03580 01S 21900261. 20 FOODJflR l i s 022000229. 00 1R03581 02S .07100248. 70 FOODJflR 12S 007200343. 10 1R03582 02S 007300245. 00 FOODJflR 12S 007400337. 20 1R03583 02S 007/00189. 30 FOQDJftR 12S 007600266. 80 1R03584 02S 0077. 0233. 40 FOODJflR 12S 007800350. 7Q 1R03585 02S 007900236. 0Q FOODJflR 12S 018800327. 60 1R03586 02S 010100252. 20 FOODJflR 12S 018200321. 50 1R035S7 02S 010300209. 60 FOODJflR 12S 010400370. 50 1R03588 02S 810500236. 1Q FOODJflR 12S 010600353. 7Q 1R03589 02S 010700224. 3Q FOODJflR 12S 010808332. 4Q 1R03590 02S 010900274. 20 FOODJflR 12S 011000319. 20 .02591 02S .11100213. 2Q FOODJflR 12S 011200251. 10 1R02592 02S 011300242. 7Q FOODJflR 12S 011488340. 10 1P03593 02S 011500239. 7Q FOODJflR 12S 011600346. 80 1R02594 02S 011700251. 80 FOODJflR 12S 011800318. 7Q 1R02595 02S 011900237. 60 FOODJflR 12S 812000332. 60 1R03596 02S 012/00232. 6Q FOODJflR 12S 012200324. 7Q 1R03597 02S 012300244. 4Q FOODJflR 12S 012400329. 9Q 1R02598 02S 012500274. 3Q FOODJflR 12S 012600325. 5Q 1R03599 02S 012700225. 60 FOODJflR 12S 012800237. 1Q 1R03600 02S 012900220. 9Q FOODJflR 12S 013000341. 80 1R03601 02S .13100254. 7Q FOODJflR 12S 813200328. 80 1R03602 02S .13300220. 70 FOODJflR 12S 013400355. 3Q 1R03603 02S .13500249. 40 'ODJflR 12S 012680340. 6Q J.P03604 02S .13700221. 1Q FOODJflR 12S 013800354. 30 1R03605 02S 013900247. 2Q FOODJflR 12S 014000342. 7Q 1R02606 02S .14100224. 90 FOODJflR 12S 014200361. 7Q 1R03607 02S .14300261. 1Q 11 1 11 1 11 1 11 1 11 1 11 1 11 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 -12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 315. 1 263. 3 339. 4 268. 4 340 283. 8 330. 6 261. 6 350. 1 258. 8 344. 1 261. 3 339 248. 7 343. 1 245 337. 2 189. 3 366. 8 233. 4 350. 7 236 327. 6 252. 2 321. 5 209. 6 370. 5 236. 1 353. 7 224. 3 332. 4 274. 2 319. 3 213. 2 351. 1 242. 7 340. 1 239. 7 346. 8 251. 8 318. 7 237. 6 332. 6 232. 6 324. 7 244. 4 339. 9 274. 3 325. 5 235. 6 337. 1 220. 9 341. 8 254. 7 328. 8 220. 7 355. 3 249. 4 340. 6 221. 1 354. 3 247. 2 342. 7 224. 9 361. 7 261. 1 428 000816 FOODJRR 12S 014400329. 2Q i r o j -608 62S 014500246 60 FOODJflR 12S 014600325 70 1R03609 02S 814700217. 00 FOODJRR 12S 014800338. 20 1R03610 02S .14900277. 90 FOODJRR 12S 015000343. 40 03611 02S .15100252. 50 FOODJRR 12S 015200322. 00 1R03612 02 0153002*8. 20 FOODJRR 12S 015400334. 10 1R03613 02S 015500. 70. 80 FOODJRR 12S 015600325. 30 1R03614 02S .15700241. 80 FOODJRR 12S 015800321. 30 1R03615 02S 015900225. 80 FOODJRR 125 016000332. 7Q 1R03616 025 016100234. 90 FOODJflR 125 016200338. 3Q 1R02617 025 016300226. 5Q FOODJRR l2> 016400342. 6Q 1R03618 025 016500244. 60 FOODJRR 125 016600323. 00 1R03619 025 016700206. 20 FOODJRR 125 016800335. 80 1R03620 025 .16900225. 50 FOODJRR 12S 017000338. 00 1R03621 025 0171002. 0. 50 FOODJRR 125 017200362. 70 '"-03622 025 .17300218. 2Q jODJRR 125 017400352. 7Q 1R03622 025 017500237. 9Q FOODJRR 125 817600329. 70 1R02624 025 01/700212. 60 FOODJRR 125 017800340. 50 1R03625 025 017900201. IQ FOODJRR 125 018000364. 30 1R03626 025 018100263. 00 FOODJRR 125 018200231. 3Q 1R03627 025 818300261. 60 FOODJRR 125 018400344. 6Q 1R03628 02S 0/8500248. 4Q FOODJRR 12S 018600339. 7Q 1R03629 025 .18700237. 80 FOODJRR 12S 018800239. 2Q 1R83630 025 018900211. 8Q FOODJRR 12S 019000364. IQ 1R03631 02S 019100264. 40 FOODJRR 125 019200342. 60 1R03632 025 019300239. 80 FOODJRR 12S 019400345. 50 1R03633 025 .19500249. 10 FOODJRR 125 019600319. 7Q 1R02634 825 019700177. 4Q FOODJRR 125 019800370. 0Q 02635 02S 01990. 187. 5Q FOODJRR 12S 820000354. 2Q 1R03636 02S .20180240. 9Q FOODJRR 125 020200347. 7Q 3R03637 025 .20388225. 0Q FOODJRR 12S 020400352. 7Q 1R03628 025 828500223. 2Q FOODJRR 125 020600332. 8Q 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 329. 2 246. 6 325 7 217 338. 2 277. 9 342. 4 252. 5 332 248.2 334. 1 270.8 325. 3 241. 8 321. 3 235. 8 332. 7 234. 9 338. 3 226. 5 342. 6 244. 6 323 206. 2 335. 8 225. 5 338 200.5 - 362. 7 218. 2 352. 7 237. 9 329. 7 212. 6 340. 5 201. 1 364. 3 263 331. 3 261. 6 344. 6 248. 4 339. 7 237. 8 339. 2 211. 8 364. 1 264. 4 342. 6 239. 8 345. 5 249. 1 319. 7 177. 4 370 187. 5 354. 2 240. 9 347. 7 225 352. 7 223. 2 332. 8 K S T COPY AVAILABLE 429 000S17 1R03639 0'b 020700221. 60 FOODJRR 1 020800352. 60 1R03640 02S 020900185. 40 FOODJRR 12S 021000361. 10 1R03641 02S .21100251. 10 FOODJRR 12S 021200239. 6Q 1R03642 02S .21300218. 2Q 00 JRR 12S 021400347. 50 J.R03643 02S .21500239. 50 FOOD-JftR 12S 021600342. 20 1R03644 028 021700229: 90 FOODJRR 12S 021800337. 20 1R03645 028 021900234. 60 FOODJRR 128 022000341. 60 1R03646 03S 022100245. 10 FOODJRR 138 022200353. 70 1R83647 03S 022300284. 40 FOODJRR 138 022400331. 50 1R03648 03S 022500274. 30 FOODJRR 138 022600322. 7Q 1R03649 03S 022700255. 2Q FOODJRR 13S 022800342. 0Q 1R03650 03S .22900260. 7Q FOODJRR 128 023000349. 40 1R03651 03S 023100261. 80 FOODJRR 138 023200336. 2G 1R02652 028 023300276. 0Q FOODJRR 138 023400344. 2Q 1R03653 028 .23500275. 9Q FOODJRR 12-S 023600335. 3Q 1R03654 02S .23700278. 0Q FOODJRR 138 823800326. 90 "R03655 03 S 023900276. 90 .iODJRR 138 024080320. 5Q 1R03656 038 024100275. 80 FOODJRR 13S 024200326. 5Q 1R03657 03S .24300266. 10 FOODJRR 12S 024400345. 3Q 1R03658 038 .24500266. 30 FOODJRR 13 S 024600342. 70 1R03659 03S 024700286. 50 FOODRR 13S 024800328. 0Q 1R03660 03S 024900266. 0Q FOODJRR 138 825800336. 20 1R03661 028 025100272. 0Q FOODJRR 138 025200340. 3Q 1R03662 028 025300242. 2Q FOODJRR 13S 025400354. 8Q 1R02663 03S 025500290. 30 FOODJRR 13S 825600314. 10 1R02664 03S 025700274. 8Q BFOODJRR 13S 025800227. 0Q 1R03665 035 025900289. 2Q FOODJRR 13S 026000332. 0Q 1R03666 03S 026100284. 3Q FOODJRR 13S 026200340. IQ 1R03667 03S 026300229. 7Q FOODJRR 138 026400367. 5Q ':03668 025 026500232. 5Q ruODJRR 13S 026600362. 4Q 1R03669 02S 026700272. 00 FOODJRR 135 026300323. 60 1R02670 02S 026900272. 7Q FOODJRR 135 027000317. 60 1R03671 03S 027100273. 00 FOODJRR 135 027200331. IQ 2 12 2 12 2 12 2 12 2 12 2 12 2 12 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 221. 6 353. 6 185. 4 361. 1 251. 1 339. 6 218. 2 347. 5 239. 5 342. 2 229. 9 337. 2 234. 6 341. 6 245. 1 353. 7 284. 4 331. 5 274. 3 322. 7 255. 2 342 260. 7 349. 4 261. 8 336. 2 276 344. 2 275. 9 335. 3 278 326. 9 276. 9 320. 5 275. 8 326. 5 266. 1 345. 3 266. 3 342. 7 286. 5 328.13 266 336. 2 272 340. 3 242. 2 354. 8 290. 3 314. 1 274. 8 327 289. 2 332 284. 3 340. 1 229. 7 367. 5 232. 5 362. 4 272 323. 6 272. 7 317. 6 273 331. 1 BEST COPY AVAILABLE 430 000818 1R0J 6 i-d 033 027200282. 8Q FOODJflR 138 O27400330. 2Q 1R03673 03 S 027500265. 20 FOODJflR 138 027600348. 2Q 1R03674 03S 027700253. 2G FOODJflR 138 027800326. IQ 1R03675 038 027900281. 8Q ODJAR 138 028000318. 9G XR03S7S 028 028100296. 1G FOODJflR 138 028200328. 5Q 1R03677 038 028300278. 8Q FOODJflR !28 028400324. 6Q 1R03678 03S 028500285. 5Q FOODJflR 128 028600323. 6G 1R03673 028 028700275. 7 FOODJflR 128 028800327. 6Q 1R036S0 02S 028900269. 4G FOODJflR 138 029000320. 7Q 1R03681 038 029100277. 2Q FOODJflR 128 029200334. 8Q 1R03682 038 029300258. 20 FOODJflR 138 029400351. 00 1R03683 028 029508266. 90 FOODJflR 138 029600341. 10 1R03684 028 029700273. 60 FOODJflR 138 029800336. 4Q 1R03685 03S 029900272. 6Q FOODJflR 138 030000343. 10 1R03686 02S 030100262. 10 FOODJflR 138 030200336. 8Q 1R83687 038 030300275. 4Q FOODJflR 128 030408329. 90 *R03688 038 030500283. 4Q jODJflR 138 030600333. IQ 1R036S9 028 030700256. IQ FOODJflR 13S 030800349. 60 1R03690 02S 030900265. 3Q FOODJflR 13S 031000331. 0Q 1R03691 038 031100264. 0Q FOODJflR 138 031200339. 80 1R03692 03S 031300252. 8Q FOODJflR 13S 031400349. 3Q 1R03693 028 031500290. 80 FOODJflR 12S 031600321. 8Q 1R03694 025 031700291. 2Q FOODJflR 12S 031800321. 7Q 1R03695 03S 031900292. 6Q FOODJflR 138 032000322. 00 9999999993 99 3 13 -* 2 13 3 13 3 13 3 13 3 0 3 13 3 13 3 13 3 13 3 13 3 13 3' 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 0 282. 8 330. 2 265. 2 348. 2 253. 2 336. 1 281. 8 318. 9 296. 1 328. 5 278. 8 324. 6 285. 5 333. 6 275. 7 327. 6 269. 4 320. 7 277. 2 334. 8 258. 2. 351 266. 9 341. 1 273. 6 336. 4 272. 6 343. 1 262. 1 336. 8 275. 4 329. 9 283. 4 333. 1 256. 1 349. 6 265. 3 331 264 339. 8 252. 8 349. 3 290. 8 321. 8 291. 2 321. 7 292. 6 322 BEST COPY AVAIlABLE TWO YEAR ORAL(DIET > TOX-ONC STUDY OF FM-2924 & FC-142 IN RATS' EXP. # 02810*0012 TECHNICIAN IN1TIALS:S MH TODAY DATE : 5.'12/81 SEX OF RATS:S MALE ROOM N U M B E R : D-346D-328 WEIGHT.OF FULL FOOD J A R : 500GRAMS WEEK 3 1R02516 01S 00710O329. 90 FOOD-JAR 11S 007206218. 80 1R02517 01S 007200206. 00 FOODJAR U S .0 0 7 4 0 0 2 2 2 40 1RG3518 GIS 0075G21O. 60 FOODJAR I I S 007600220. 00 1R03519 OIS 00 770O235. 50 FOODJAR l i s 00 7800218. 50 1R02520 01S 0079G021S. 40 FOODJAR l i s 01OO00228. 10 1RS2521 OIS 010100282. 50 FOODJAR l i s 010200226. 10 1RQ2522 OIS 010200205. 20 FOODJAR: l i s 010400228. GO 1R02522 GIS O1050222. 30 FOODJAR l i s 010600224. 70 ; `32524 GIS 0107G02S6. 40 FwODJAR 11S G1080O248. 20 1R03525 GIS 010900291. 40 FOODJAR l i s 011000227. 70 1R02526 GIS O11100207. 30 FOODJAR: 11S 0112010222. 60 1R02527 o is 011200301. 70 FOODJAR u s 011400228. 20 1R02528 OIS 0115G22G. 60 FOODJAR l i s 01160O228. 10 1RG2529 OIS 01170O210. 60 FOOD'JAR: l i s 011800318. 40 1R03520 eus 011900.426. 50 FOODJAR: u s 012000220. 40 1R02531 o is 012100306. 10 FOODJAR u s G1220G228. 50 1R02522 GIS 0122002-07. 20 FOODJAR: 11S 01240 0227. 20 1R02522 GIS 012500228. 30 FOODJAR 11S 0126O0214. 20 1R02524 GIS 012700220. 10 FOODJAR l i s 0128O0219. 80 1R03535 GIS G1290G274. 20 FOODJAR l i s 013-000251. 60 1R02526 GIS 013100292. 30 FOODJAR 11S 012200228. 70 J2537 GIS G1220O292. 10 FOODJAR: 11S 01340 0228. 80 1R02528 GIS 012500229. 80 FOODJAR 11S 012600324. 40 1R0252S1 G IS 0127GC3272. 50 FOODJAR 11S 01380 0249. 80 1R03540 GIS 012900286. 70 Fnnn.TAR 1 1 : Ift 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 '1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 229. 9 318. 8 3G6 332. 4 31G. 6 330 235. 5 218. 5 218. 4 228. 1 292. 5 336. 1 305. 2 238 _ * 323. 3 334. 7 286. 4 249. 2 291. 4 J . f` 3G7. 3 222. 6 201. 7 33&. 2 320. 6 328. 1 210. 6 318 4 326. 5 330 4 3G6. 1 328. 5 207. 2 227. 3 338. 3 314. 2 22G. 1 219. 8 2F4. 2 251. 6 292. 3 328. 7 292. 1 338. 8 229. e 224. 4 2?2. 5 349. 8 286. 7 339 4 BESTCOPY AVAILABLE 432 C 00820 1802541 0 1 S 014100306. 20 FOODJftF: lis 014200215. 60 1803542 eis 014300311. 90 FOODJftF: u s 014400322. 30 1R02542 01S 014500216. 50 FOOD'JftF: lis 014600212. 00 --03544 OIS 0147002-14. 50 , JC'.THF: lis 014800222 60 1R02545 01S 014900329. 60 FDOC'JHF lis 015000320. 70 IF:33546 0 1 S 015100317. 20 FOODJftF: lis 015200226. 30 1R03547 01S 015200294. 50 FOODJftF: l is 015400214. 90 1R0354S 01S 015500239. 10 FOODJftF: lis 15600224. 10 1R03549 01S 015700201. 00 FOODJftF: lis 015800245. O 1R02550 01S 015900208. 10 FOODJftF: lis .016000225. 80 1R03551 01S 016100240. 90 FOODJftF: lis 0162O0370. 20 1F02552 01S 016200206. 80 FOODJftF lis 016400218. 40 1R03553 01S 016500317. 80 FOODJftF: lis 016600216. 00 1R02554 018 016700275. 70 FOODJftF lis 016800242. 10 1R02555 01S 016900296. 80 FOODJftF: lis 017000241. 60 1R02556 eis 017100210. 00 FOODJftF lis 017200218. 00 ?2557 01S 017200214. 30 FuODJftF: lis 017400225 00 1R0255S 01S 017500278. 10. FOODJftF: li s 017600354. 20 1R02559 eis 017700321. 30 FOODJftF: u s 017800222. 40 1R0356O 01S 017900204. 90 FOODJftF: u s 018000348. 90 1R03561 OIS 018100211. 80 FOOD'JftF: lis 018200312. 30! 1R03562 01S 018200272. 00 FOOD'JftF: lis 018400252. 60 1R03563 0 1 S 018500308. 30 FOODJftF: lis 0186G0340. 20 1R03564 01S 018700284. 00 FOODJftF: lis 01880G240. 90 1R03565 OIS 018900216. 40 FOODJftF.: lis 19000225. 10 1R03566 01S 019100300. 00 FOODJftR lis 019200321. 00 1R03567 01S 019200222. 50 FOODJftF: lis 019400324. O 1R0256S 01S 019500236. 70 FOODJftR li s 019600229. 40 1P03569 01S 019700222. 10 FOODJftR l is 019800223. 00 ii 03570 01S 019900296. 60 FOODJftF: u s 820000217. 60 1R02571 01S 028100319. 20 FOODJftR lis 020200212. 40 1RG3572 01S 0 2 02 00 20 2. 00 FOODJftR lis 020400226. 30 1R03572 01S 020500227. 80 crii-ir. Tac- HC A jf*tf".i*Ci" C-*7 "7C\ i ii i il i il i il i ii i il i il i il i il i il i il i il i il i il i il i i l i il i il i il i il i il i il i il i il i il i il i il i il i il i il i il i il i 1i 306B2ESTEOPY AVAII ABLE 315. 6 311. 9 322. 3 316. 5 312 314. 5 322. 6 329. 6 320. 7 317. 3 326. 3 294. 5 314. 9 339. 1 324. 1 301 345 308. 1 335. 8 240. 9 370. 2 306. 8 318. 4 317. 8 316 275. 7 343. 1 290. 8 341. 6 310 318 314. 3 335 278. 1 354. 3 321. 3 333. 4 304. 9 348. 9 311. S 312. 3 272 353. 6 308. 3 340. 2 284 340. 9 316. 4 335. 1 300 331 322. 5 324 336. 7 329. 4 322. 1 323 296. 6 317. 6 319. 2 312. 4 302 336. 3 327. 8 3-7 7 433 000321 ro ^r W CJ ^ 00 2 o ..l..U....i..N....H........1.4...W....If.i..t....W....M........t....I.f.l..O.J...f.fl....I......f.f.l......U..l..0....0..i..(..i..U..l..-.H...I.f.)..0....r.H...G....C.D..0.....C..-..t.r.i..C.O...l.i...C.J...f.-...O.t.l..C.d...C.J..0..0...0.0......f.'.-..0.0...N....0..i......0....U..l..0....0.......C..D..l.i...r.lM t.I..l..i..N........C.M...N....h.i..0..0 0i G00111M0 Gli MOl t flOION mKN I n (\l Orl MtI O) I- CMO)CM Nli I tl H00 CM Gli CM CM 0i li 0i li 01CM N CM111li 01Nh) 0 IDCM00CMCMin*00 hi tM0i N00I'tMCM hl Ul 0) I- CM I'0) G0 CD 00fi Ul ri CD li li Ji li ID CD CM0 hi GID0 li N00 . t HMh >9 ADN hi 11lM M rt'M'JHt CI NhM11Ml 0 hi0 KMrtIMMmiMMCMMOIMNMfMMNMHMNMCMMNMNMNrtN C1CMliCM li CM fi CMlvl CMMCMli CM li CMcl Mli CMli CMli CMli CM CMli CMMCMli CMliI I ri I ri H tM tM t H H rl HH HH H rl H CM Hd CM CM H rl CM CM CM 'M r l t I CM r l CM CM ` M CM CM *'1 CM CJ rl CM rl CM r l CM ri CM CM CM -H CM CM CM H 'M CM CM H CM CM CM CM CM t \ CM t I CM t M CM H CM ri CM ri CM ri i 3GGGGGGGGGGGGGGGGG3G*33333GG3GGGGGO Q*O *33 G3*33l*. 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T .0 1 TWO VERR ORRL<.DIET> TOX-ONC STUDV OF FM-2924 & FC-143 IN RRTS EXP. 0281CR0012 TECHNIC IRN INITIRLS:S MH TODRV'S D R T E :S 5/19/81 SEX OF R R T S :S MRLE' ROOM NUMBER :S D-340,t'-23S WEIGHT OF FULL FOOD JRR:S 525GRRMS WEEK 4 1R02516 eis ee?100255. 2Q FOODJRR n s 00?20e332. 40 1R03517 eis 00 7300331. 40 FOODJRR n s 007400352. 60 1R02518 eis 007500329. 20 FOODJRR n s 00 7600317. 30 1R02519 eis 007700366. 50 FOODJRR n s 007800323. 10 1R0352 eis 007900351. 30 FOODJRR n s 010000337. 90 1R02521 eis 010100213. 40 FOODJRR n s 010200257. 60 1R03522 eis 010300230. 90 FOODJRR n s 810400357. 10 1R03522 eis 010500351. 60 FOODJRR n s 010600351. 30. 1R02524 eis 010700316. 60 FOODJRR n s 010800261. 60 1R02525 eis 010900320. 20 FOODJRR n s 011000226. 90 1R02526 eis 011100225. 90 FOODJRR n s 011200349. 40 1R02527 eis 011200223. 90 FOODJRR n s 011400262. 90 1R82528 eis 011500251. 80 FOODJRR n s 011608242. 80 1R03529 eis 011700339. 20 FOODJRR n s 011800343. 50 1R0253 eis 011900346. 70 FOODJRR n s 012000345. 60 1R03531 eis 012100230. 70 FOODJRR n s 012200252. 90 1R03522 FOODJRR eniss 012300325. 20 012400349. 90 1R02532 eis 12500363. 20 FOODJRR n s 012600338. 60 1R03534 eis 012700273. 60 FOODJRR n s 012800221. 50 1R03535 01S 012980296. 00 FOODJRR IIS 013000270. 60 1R03536 01S 013100317. 40 FOODJRR U S 013200360. 70 ! 2537 01S 013300202. 80 FOODJRR 11S 013400353. 00 1R02528 01S 13500261. 80 FOODJRR 11S 013600226. 10 1R02529 eis 013700284. 70 FOODJRR n s 013800381. 10 1R03540 eis 013900389. 80 Fnnr>.TRR 11 F 01 4000161. 50 1 11 1 11 1 11 1 11 1 11 1 11 1 11 -1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 . 355. 2 323. 4 221. 4 353. 6 329. 2 217. 3 366. 5 323. 1 251. 237. 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B 342. 6 239. 3 343. 5 346. 7 245. 6 220. 7 253. 9 335. 2 349. 9 363. 2 328. 6 373. 6 221. 5 296 270. 6 317. 4 360. 7 202. 8 353 361. 8 BEST COPY AVAILABLE 336. 1 284. 7 381. 1 309. 8 361. 5 438 000826 Cd il 11 * CB N OiODCD Od H H N M H Oi r* OD AI `B rr Ol ll Pi V PI P- P- Oi Oi OD fl Oi MtH N ll Ol H ri f ri Al Al CD ID li (M H H W 0<MB 00CO 5 O Ir"l)01 11 l*lM3 0dr1i rlblllO0*'%!0*r1Bl MPITI) l'**i>iIlTD i>VlD PrOIil 11I11-Mrrdr PAOIl CpOl-d PPlIii PitnTiAb(llMl1O"1i) P0ri1l PPri-r PiOIiPWrid M0*0B Hd(fptlOrldd PPCIlb PcIB PCOIdi 1rT1dP lP'I0 OOidit 0Cp1d- 0Orj1i-0h1i 1r(1ih ffIri- OD 01 N1r1i OrOdll f 0O1D rO0ld1 *D i1n1 0Sr1Ii 0O3i1l0Cr 1Or 0H1 0CI1dD ID 0in1 0D31i0AP1lU0AB1l 0lb'1lJ0Oi1f ri 0r 1r 1Al1Ii 0rP1d- 0OC1dB rCOidd 01P11i1U031l 0Nb1lfCid irlTdTdTdrdTdTdTdTdTdTdrdTdTdTdTdTdTdTdTdTdTdTdTdTdTdTdTdTdTdrlTdTd TdrltdTdrlrlTlrlrlTdTdTdTdtdTlTlrdtdTdTdrlTdtdTdTdTdrlrlTdtdrlTdTlTdrlrlHrlrlTdrlHHTdHTdrlTdHTdrlHTdHtdTdTdTlTdTlHTdHTdTdTl G*4 M <iSl r'r3 'B 03- 3Oi 33 O3D CiM 3ii 33 33 3rd A3i iGl rGd 3O aa Ol * a 3 <2 CO O3 AClS >Cf3la3 >rr3 O3i <031 N>3 arr oPi *33 `N3 *N3 G 0\ O3. 33 0*13 GG >3 Ti 1a1 >3 NQ i13- 'P3i QOi 3>3 3Or<l3TGdirOrrCd3<<-3A<|3r>r30<d3 33 3g CsO iijl Od bal ari crii 3a <:o ' G g 'T G r!GG'/'.dJJ Gd'T r33i.jil1) 3HrOl r33d3r-ip 3frd 313033rd11r11r3r3f'3rddil l10r331-i1iD0i331)-li'rrD33dii Td d0 "d 333 U t gGGiHGn 331.r3tr1B1dd1>i1r3A33r1rlld1 Cl33lrb3rrilBid D MrG3i3rrr*nid lOlNib33rvinidll33'mrrr3riBdd 3O3l033ir-indl A03b3313r-Ii1d III33Om3rlilld b03r33l1r `3rd bj033rlJdj `3rd bGoCIG-iuh1 *H G Ci330'r3rDl1Ddd P1I'333tr1Bd O`133bBi1l Gri 3'il3'3rrBnidd>330P''O3rLB-)ddl 3Ori33IrBrild 033rl1di1rI331iI Oi 3 '3rBd N3rd `i3BfllA13Ol1i 3P3rr-dd 0P33r-dd 13rr1rd 1133r1d- II3313rr-Blrld bprT333-l-iTdd rr:GG-.i ' GH Ji P13.3r-V13-d 1P3<3br'r1-3ldi TiPO333rr-ilidd riGGGGrH:-iio T P CO i3l 33rCrdOd 3033!OAr')ldi-O33P0Grcr)iiidd 30GO*Hc3Ir)i 3b3OGri3rildld3'pG3b3CrBilBd3NGo033rr3idl3ObcGC33riOlidi O30iG3Grrir1ld0rG33GrPrfiliir3GlGArb3dilll 33GAmi'GrIlBl33GrMPbOG3ilid3Gr11OG*311dlO3Grb0COGll1Bdi3Grb*OGPOlilBii3GriP0OG1d-1" Horr 11 ai pi or0i- n<Ood Odin oai opi o3O o3Ni iOrlrd 0OSOr0d)lOOOrSilMCG3iSdS)iAr&)lliSO3dMiGOOt3f)dI0OA3TSlfOMtA3fl)9OCCi0Dd ud g Odd 03H1 3rrdd 03r1d lrr/ddlr03d1 0rr1dd '3r/dI i TH 03r1d 0rr1dd 03r1d 0rr1dd 0r31d Urr)dd 0r31d 0rr1dd 03r1d 0rr1dd 03r1d UrHH 03r1d 0rr1dd LGd'I 0rr1dd 3lrid 0rr1dd 03r1d 0rr1dd 03r1d 0rr1dd l3r/dl 0rr1dd 03r1d rUHd O3rid 0rr1dd 30r1d 0-rHl (Or3id r0rl1d 03r1d 0rr1ld 03r1d 0rr1dd 33rd 3rrdd 33rdr3rllr33lrr3llr33lrT3ddr33lrr3llr30d1 l/l3 3 TdTdr Td3rl 3 dH 3T 3 01 tdHt d3T 3 d d U1 rdt 3T 01 d d H mrGCdLi CLr Coou.d 3rm0CrrMO1d -LrO OCOt li. li li:i LL 111 r1l3Cr.rLdi1*oOUClt.i>o1lrH'1Oi.1oCl*il1olil1rliidi.- CL <L COGU.i 'UrOrl CtI-L. I3CrLdlUOoC.i 1rbl3C-rLli ri ULtOO-L.>0bI3Ctii0lLd I3t*0O-L.>D3C0briLli1d CtL UO03. 3bmP3irliLd 3UOtiCOL. iC3brblldli rd L*Lr> IGOOI 0bbI3lldl CrLd ICOE3nL O- iiGLUdvLiliiIt3iot_L>i1biCb3rLllll Ct*3OOUL1. bbbi3CrllLlld U>3ODtO-..> mm3Oiil 3*t0C-L>lImb3-iiIrrLloIL CrLd .'*Yi t13OOIL ibP3nli CrLd i0r: Ci uOLL bbPGTlliii CrLd Ct3L> i_ i UO. 3 3`b1l1 CrLd C<>3Lr>urXiiLLr ICUOLt CrGHLiUOCO_i bPCAi3rliLJd CIL 11B U1OC>_.l>bI3rOLlli 1CtL IOCOLi bCPrH'3LlITdB tCL O-- / IOOI bl CL B CL t- CL 3 CL 3 bP3CrBiIlL0OE3lO>LC0rCPmBIlL0ltCO-iL>C3r*iPLlBin0lOtCLlC3r>bPLlBii0lOtiLLJi3r<biLllBi CL 3 CL rd CL Od CL PICL IM M M M a1 111 *1 111 *1 111 *1 111 *1 il Ci li o o o OrL_.^H:OUO.TEdIlLiiOO.rOdOCtiOO.TOIdLlOlo. 1R03574 015 02O700275. 50 FOODJRR: 115 020800229. 20 1R03575 015 020900285. 80 FOODJRR 115 02100024c-, 20 1R03576 01S 021100228. 70 FOODJRR 11S 021200248 80 1*02577 01S 021200238. 40 , JDJRF: u s 021400258. 40 1R02578 is 0215002-15. 50 FOODJRF: 11S 021600358. 50 1R02579 01S 021700317. 10 FOODJRF: u s 021800265. 40 1RO35S0 is 021900300. 70 FOODJFiR 11S 022000217. 40 1R025S1 02S 00 "'100205. 10 FOODJFiR 12S 007200245. 90 1R02582 025 007200262. 70 FOODJFiR 12S 007400279. 10 1R03582 02S 007500211. 30 FOODJRR 12S -007600390. 00 I R 03584 02S 00 7700272. 70 FOODJFiR 12S 00 7800367. 60 1R025S5 02S 00 7900276. 60 FOODJFiR 12S 010000340. 40 1R03586 02S 010100298. 40 FOODJRR 12S 010200250. 50 1R35S7 02S 010200249. 10 FOODJRR 125 010400277. 60 1R03588 02S 01050O278. 00 FOODJRR 125 010600282. 50 1R025S9 02S 010700260. 50 FOODJRR 12S 010800244. 20 1R03590 025 010900350. 30 FOODJRR 12S 011000219. 50 1R02591 82S 011100241. 10 FOODJRR 125 011200288. 60 1R03592 02S 011300291. SO FOODJRR 125 011400259. 20 1R02593 025 011500295. 30 FOODJRR 12S 011600263. 20 1R02594 025 011700305. 50 FOODJRR 125 011800320. 20 1R02-595 02S 011900283. 00 FOODJRR 125 012000359. 10 1R02596 025 012100288. 90 FOODJRR 125 012200252. 90 1R02597 025 012200275. 50 FOODJRR 125 012400277. 30 1R03598 02S 012500325. 00 FOODJRR 12S 012600356. 50 1R02599 02S 012700283. 60 FOODJRR 12S 012808353. 50 1R03600 02S 012900249. 50 FOODJRR 12S 013000387. 00 1R63681 02S 013100306. 20 FOODJRR 125 013200340. 10 1R02602 02S 013300267. 50 FOODJRR 12S 013400271. 20 L J3603 02S 012500284. 40 FOODJRR 125 013600266. 70 1R03604 02S 013700248. 20 FOODJRR 125 012800280. 70 1R03605 025 012900268. 80 FOODJRR 125 014000281. 40 1R03606 025 014108279. 40 FOriD.TRR 125 01 470077i 0O 1 11 1 11 1 11 1 11 1 11 ' 1 11 1 11 2 12 12 2 12 2 12 2 12 2 12 2 12 2 12 .2 12 2 12 2 12 C. 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 1CO.2 12 2 12 2 12 2 12 2 12 375. 5 329. 3 305. 8 346. 3 336. 7 348. 8 336. 4 358. 4 315. 5 358. 5 317. 1 365. 4 300. 7 317. 4 - 305. 1 345. 9 262. 7 379. 1 211. 3 390 273. 7 367. 6 276. 6 340. 4 298. 4 350. 5 249. 1 377. 6 278 383. 5" 260. 5 344. 2 350. 3 319. 5 241. 1 388. 6 291. 8 259. 2 295. 2 263. 2 285. 5 220. 2 282 259. 1 288. 9 352. 9 275. 5 277. 2 325 356. 5 282. 6 353. 5 249. 5 287 306. 2 340. 1 267. 5 371. 3 BEST COPY AVAILABLE284. 4| 266. 7| 248. 2 * 380. 7 268. 8 381. 4 279. 4 376 440 000828 1RO2607 02S 014300217. 00 FOODJAR 12S 014400250. 60 1R02606 025 014500202. 00 FOODJAR 125 014600230. 60 1R02609 02S 014700264. 30 FOODJAR 125 814800254. 3Q ' 03610 025 014900332. 60 , .00JAR 125 015000260. 70 lR03t.ll 025 015100231. 70 FOODJAR 12S 015200269. 50 1RG2612 02S 0152-00292. 10 FOODJAR 12S 015400262. SO 1R03612 025 015500344. 00 FOODJAR 12 015600338. 70 1R02614 025 015700282. 20 FOODJAR 12 S 015800229. 80 1R03615 02S 815900270. 80 FOODJAR 125 016000358. 70 1R0361S 02S 016100286. 5Q FOODJAR 125 016200253. 50 1R03617 025 016300279. 60 FOODJAR 12S 016400351. 50 1R02618 02S 016500209. 50 FOODJAR 12S 016600220. 90 1R02619 02S 016700223. 90 FOOD JAF: 12S 016S00269. 50 1R0362O 025 016900264. 70 FOODJAR 12S 017000255. 30! 1R02621 025 017100224. 90 FOODJAR 12S 017200298. 10 1R02622 02S 017208256. 20 FOODJAR 12S 017400275. 70 1R03623 02S 017500260. 90 FOODJAR 12S 017600268. 00! 1R03624 02S 017700264. 10 FOODJAR 12S 017800264. 60 1R03625 02S 017900217. 70 FOODJAR 12S 018000277. 10 1RG3626 02S FOODJAR 12S 018200354. 90 1F:02S27 02S 018200298. 50 FOOC'JAF: 125 018400272. 50 1R02628 02S 018500282. 10 FOODJAR 12S 018600276. 80 1R03629 02S 018700292. 20 FOODJAR 12S 018800360. 40 1R02630 02S 018900241. 40 FOODJAR 12S 019000393. 30 1R03631 02S 019100221. 00 FOODJAR 12S 019200362. 50 1R02622 02S 019200284. 30 FOODJAR 125 019400276. 10 1R83<622 025 019500305. 70 FOODJAR 125 019600325. 40 1R03634 025 019700208. 90 FOODJAR 12S 019800378. 10 1R03635 02S 19900206. 10 F'ODJAR 125 020000376. 20 i.. . 2 6 3 - 6 82S 020100297. 00 FOODJAR 125 020200350. 40 1R03637 025 020300261. 20! FOODJAR 12S 620400256. 30 1R02638 025 020500259. 50 FOODJAR 125 020600360. 90 1R03639 025 020700262. 40 p n n r i t & p -1o c . PtVetSt&CiT: ACl tL 12 2 12 2 12 2 12 12 * 2 12 12 2 12 ci 12 2 12 2 12 2 12 ci 12 tm 12 cZ 12 2 12 2 12 2 12 ei 12 cL 12 2 12 1^.' 2 12 2 12 2 12 2 12 ci 12 2 12 2 12 2 12 2 12 2 12 2 1o 217 350. 6 202 320. 6 264 3 254. 3 223. 6 260. 7 281. 7 369. 5 292. 1 263. 8 344 328. 7 283. 3 339. 8 270. 8 358. 7 286. 5 353. 5 279. 6 351. 5 209. 5 230. 9 223. 9 369. 5 264. 7 255. 3 224. 9 .298. 1* 256. 2 375. 7 260. 9 368 264. 1 364. 6 217. 7 277. 1 298.5 254. 9 298. 5 272. 5 283. 1 376. 8 293. 2 368. 4 241. 4 392. 3 321 363. 5 284. 2 376. 1 305. 7 325. 4 208. 9 378. 1 206. 1 276. 2 297 350. 4 261. 2 356. 3 BEST COPY AVAILABLE 259. 5 360. 9 262. 4 5 A 441 000829 1R02640 025 020900158 60 FOODJRR 1 2 S 021000283. 90 1P02641 02S 021100206. 00 FOODJRR 12S 021200259. 20 i r 3642 02S 021300256. 00 FOODJRR 12S 0214002 71. 20 i03642 02S 021580294. 20 . JDJRR 12S 0216OO25S. 20 1R02644 02S 02170O251. 90 FOODJRR 12S O2180O367. 00 1R02645 25 02190O296. 60 FOOL1JRR 125 022000348. 00 1F.'02646 02 S 02210O288. 40 FOODJRR 135 022200366. 60 1R03647 03 S 02220032S. 00 FOODJRR 12S 022400358. 80 1R02648 02S 022500354. 10 FOODJRR 13S 022600313. 10 1R02649 03S 022788322. 10 FOODJRR 125 022800346. 00 1R03650 03S 02290O308. 00 FOODJRR 12S 023000266. 70 1R02651 02S 023100325. 80 FOODJRR 12S 023200355. 10 1R02652 02S 022300327. 30 FOODJRR 135 022'40G36O. 60 1R03-652 03^* 823500220. 50 FOODJRR 135 O23600357. 20 1R03654 03S 023700249. 00 FOODJRR 13S 023800341. 80 1R02655 025 02390G325. 10 FOODJRR 135 024000228. 00 1R02656 025 024100332. 10 FOODJRR 125 02420025G. 10 1R03657 03S 02430O224. 20 FOODJRR 135 024400359. 60 1R02658 025 02450O228. 90 FOODJRR 135 024600260. 20 1R03C-551 035 024700331. 10 FOODJRR 12S 02480O249. 70 1R03660 02S 02490O325. 00 FOODJRR 125 025000252. 20 1R02661 02S 025100336. 50 FOODJRR 125 025200249. 00 1R02662 025 025300277. 60 FOODJRR 135 025400388. 20 1R02662 02S 025500262. 20 FOODJRR 135 02560O214. 50 1R02664 03S 025700326. IQ FOODJRR 125 025800257. 20 1RG3665 035 025900228. 00 FOODJRR 13S 026000252. 70 1R03666 03S 026100339. 40 FOODJRR 13S 026200349. 10 1R03667 03S 026300264. 30 FOODJRR 135 026400388. 60 1R02668 03S G26500268. 70 FOODJRR 12S 026600279. 70 k 3 6 6 9 02S 026700330. 40 FOODJRR 125 026800338. 50 1R83670 025 026908239. 60 FOODJRR 135 027000317. 30 1R02671 03S 027100225. 80 FOODJRR 125 027200225. 70 1R03672 035 027300329. 5Q FOOD-TAR 12S 027400346. 80 12 2 1^! 2 12 12 m 12 2 12 2 12 3 13 3 13 3 12 3 13 3 13 2 13 2 13 3 13 .2 12 3 13 13 13 313 3 13 3 13 13 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 198 6 282. 9 206 359 2 256 371. 3 294. 2 358. 2 251. 9 367 296. 6 348 288. 4 366. 6 338 358. 8 354 1 313. 1 322. 1 346 308 366. 7 225. 8 355. 1 327. 2 360. 6 320. 5 357. 2 349 341. 8' 335. 1 228 322. 1 350. 1 324. 2 359. 6 228. 9 368. 2 231. 1 349. 7 325 352. 2 336. 9 349 277. 6 388. 2 362. 2 214. 5 326. 1 257. 2 328 352. 7 339. 4 349. 1 264. 2 388. 6 268. 7 379. 7 330. 4 238. 5 339. 6 317. 2 325. 8 BEST COPY AVAILABLE 325. 7 339. 5 346. 8 G00830 1R83673 02 027500317. 80 FOODJflR 12S 027600264. 00 1R03674 03S 027700319. 00 FOODJflR 13S 027880352. 80 1R03675 02S 027900351. 80 FOODJflR 12S 028000324: 50 '"02676 03S 028100374. 10 \ JDJflR 13S 028200326. 60 1R02677 025 028300227. 70 FOODJflR 12S 028400225. 10 1R0267S 02 028580342. 00 FOODJflR 13S 028600358. 20 1R02679 03S 028700328. 90 FOODJflR 12S 028800240. 80 1R03680 03S 828900240. 00 FOODJflR 13S 129000323. 70 1R03681 03 029100245. 00 FOODJflR 135 029200236. 70 1R3682 02S 029200210. 40 FOODJflR 125 029400272. 20 1R03683 02S 029500246. 90 FOODJflR 13 029600240. 00 1R02684 02 029700342. 70 FOODJflR 13 029800232. 60 1R03685 02S 029900219. 10 FOODJflR 13 030000358. 80 1R02686 03 030100311. 60 FOODJflR 13 020200241. 60 1R03687 03 030300320. 70 FOODJflR 13 020400346. 70 1R02688 02S 030500222. 80 FOODJflR 12S 020600347. 00 1R03689 02S 030700202. 90 FOODJflR 13 020800362. 70 1R03690 02 020900225. 00 FOODJflR 12S 031000326. 50 1R02691 02 021100217. 20 FOODJflR 135 031200261. 30 1R03692 03 021300287. 60 FOODJflR 13 031400384. 60 1R02693 03 031500272. 20 FOODJflR 13 031600318. 50 1R03694 025 031700240. 7Q FOODJflR 13 031800318. 80 1R03695 03S 031900258. 90 FOODJflR 135 032000329. 10 9999999999 99 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 '3 13 3 13 3 12 3 12 3 13 2 13 3 13 3 13 3 13 3 13 3 12 3 13 0 317. 8 364 319 352. 8 351. 8 . 324. 5 274. 1 336. 6 337. 7 335. 1 342 358. 2 338. 9 340. 8 240 322. 7 345 336. 7 310. 4 372. 2 346. 9 340 342. 7 332. 6 319. 1 358. 8 311. 6 341. 6 320. 7 346. 7 332. 8 247 302. .9 362. 7 325 326. 5 217. 3 361. 3 287. 6 .384. 6 372. 2 318. 5 340. 7 318 358. 9 329. 1 BEST COPY AVAILABLE 443 000831 TWO YEAR O R A L 'D I E T > TOX-ONC STUDY OF FM-2924 & FC-142 IN RFiTS EXP. # 0281CR0012 TECHNICIAN INITIALS:S MH TODAY'S D A T E :S 5/26/81 SEX OF R A T S :S MALE ROOM N U M B E R :S D-240, D-338 . WEIGHT OF FULL FOOD J A R :S 550GRAMS WEEK. 5 1R02516 01S 007000388. 6Q FOODJAR IIS 007100358. 0Q 1R03517 01S 007200257. 20 FOODJAR U S 007300386. 8G 1R0251S 01S 007400355. 7Q FOODJAR 11S 007500389. 60 1R02519 01S 007600389. 80 FOODJAR IIS 007700361. 80 1R03520 01S 007800382. 50 FOODJAR U S 007900364. 20 1R03521 01S 010000345. 90 FOODJAR U S 010100235. 70 1R03522 01S 010200254. 90 FOODJAR U S 010300394. 2Q 1R03523 01S 010400388. 70 FOODJAR U S 010500377. 40 1R03524 01S 010600340. 90 FC--IDJAR U S 010700385. 8Q 1 3525 01S 010800257. 6Q FOODJAR U S 010900277. 30 1R03526 01S 011000353. 50 FOODJAR U S 011100383. 60 1R03527 01S 11200361. 70 FOODJAR U S 011200389. 90 1R02528 01S 011400379. 20 FOODJAR U S 011500278. 70 1R03529 01S 011600265. 60 FOODJAR U S 011700376. 10 1R03520 01S 011800277. 3Q FOODJAR U S 011900377. 00 1R03531 01S 012000253. 80 FOODJAR U S 012100392. 40 1R03532 01S 012200363. 80 FOODJAR U S 012300363. 7Q 1R03533 01S 012400370. 4Q FOODJAR U S 012500282. 20 1R03534 01S 012600396. 90 FOODJAR 11S 012700360. IQ 1R03535 01S 012800320. 00 FOODJAR U S 012900350. 7Q 1R03536 01S 013000339. 20 FOODJAR U S 012100398. 80 1R02537 01S 013200325. 7Q F DJAR U S 013200369. 80 1R03538 01S 013400286. 40 FOODJAR U S 013500375. 20 1R03539 01S 012600295. 80 FOODJAR U S 013700407. 0Q 1R03540 01S 013800339. 20 FOODJAR U S 013900384. 50 1R03541 01S 014000369. 7Q 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1' 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 388. 6 358 357. 2 386. 8 355. 7 389. 6 389. 8 361. 8 382. 5 364. 2 245. 9 225. 7 254. 9 394. 2 388. 7 377. 4 340. 9 385. 8 357. 6 277. 3 353. 5 383. 6 361. 7 389. 9 279. 2 378. 7 365. 6 376. 1 277. 3 277 353. 8 292. 4 363. 8 262. 7 270. 4 382. 2 296. 9 260. 1 320 250. 7 329. 3 398. 8 225. 7 369. 8 386. 4 375. 2 295. 8 S 2 BEST COPY AVAILABLE 384. 5 369. 7 444 000832 h i-JUL1.1HR 11S 0 14 10038,-. 10 1R82542 01S 014200368. 70 FOOD1JAR U S 01430O370. 00 1R02543 01S 01440O402. 70 FOODJAP 11S 014500335. 60 1R03544 01S 014600357. 20 FOOD JAR 11S 014700384. 30 1 3545 01 014800391. 60 F>. jD JAR IIS 014900370. 90 1R03546 01S 015000382.- 50 FOODJAR l l s 015100372. 60 1R03547 01S 015200273. 70 FOODJAR 11S 015300353. 50 1R03548 01S 015400406. 30 FOODJAR 11S 015500366. 30 1R03549 01S 015600349. 90 FOODJAR 11S 015700383. 50 1R03550 01S 915800347. 10 FOODJAR IIS 015900383. 00 1R03551 01S 016000280. 60 FOODJAR 11S 016108417. 70 1R03552 01S 016200361. 40 FOODJAR IIS 0163 00349. 90 1R02553 01s 016400406. 00 FOODJAR 11S 016500355. 10 1R02554 01S 016600306. 30 FOODJAR U S 016700401. 40 1R03555 01S 016800346. 00 FOODJAR 11S 016900390. 90 1R03556 01S 017000386. 30 FOODJAR IIS 017100381. 3Q 1R02557 01S 017200347. 40 FOOD*JAR 11S 017200408. 00 1 "iFISR: 01S 017400308. 50 FOODJAR IIS 017500398. 80 1R02559 01S 017600369. 50 FOODJAR 11S 017700386. 70 1R03568 01S 017860341. 60 FOODJAR IIS 017900396. 40 1R02561 01S 018000399. 80 FOODJAR IIS 018100348. 60 1R03562 01S 018200308. 20 FOODJAR 11S 018300402. 90 1R02563 01S 018400343. 50. FOODJAR 11S 018500389. 6Q 1R03564 01S. 018600338. 0Q FOODJAR 11S 018700372. 0Q 1R03565 01S 018800371. 20 FOODJAR 11S 018900375. 10 1R03566 01S 019000345. 5Q FOODJAR 11S 019100383. 40 1R03567 01S 019200390. 20 FOODJAR 11S 019300359. 10 1R02563 01S 019400375. 2Q FOODJAR 11S 019500394. 70 1R03569 015 019600377. 40 FOODJAR U S 019700373. 30 1R03570 eis 019800378. 70 F -DJAR 115 019900329. 6Q 1.J3571 015 020000386. 5Q FOODJAR 11S 020100357. 50 1R03572 015 020200362. 4Q FOODJAR 11S 020300373. 10 1R03573 01S 020400373. 7Q FOOD TAR 115 020500386. 3Q 1R03574 01S 020600410. 9Q 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1. 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 a. 368 7 370 402. 7 335. 6 357. 2 384. 3 391. 6 370. 9 383. 5 372. 6 373. 7 353. 5 406. 3 366. 3 349. 9 383. 5 347. 1 383 280. 6 417. 7 361. 4 349. 9 406 355. 1 306. 3 401. 4 346 390. 9 386. 3 381. 3 347. 4 400 308. 5 398. 8 369. 5 386. 7 341. 6 396. 4 399. 8 348. 6 308. 2 402. 9 343. 5 389. 6 338 372 371. 2 375. 1 345. 5 383. 4 390. 2 359. 1 375. 2 394. 7 377. 4 373. 3 378. 7 SSS BEST COPY AVAILABLE 357. 5 362. 4 373. 1 373. 7 386. 3 410. 9 445 000833 MJUDJHK 118 OtOi 0088 /'. 7U 1R02*}75 01S 020800324. 00 FOODJftR lis 020900382. 0Q 1R03576 01S 021000364. 90 FOODJftR lis 021100276. 70 1R03577 01S 021200371. 20 FOODJftR lis 021300369. 20 i 2578 01S 021400349. 30 FuODJflR lis 021500366. 10 1R02579 01S 021600345. 70 FOODJftR lis 021700386. 00 1R03580 01S 021800241. 6Q FOODJftR lis 021900267. 30 1R02581 02S 007100334. 30 FOODJftR 12S 00?200270. 70 1R03582 02S 007300271. 50 FOODJftR 12S 007400406. 90 1R03583 02S 007500234. 9Q FOODJftR 12 S 007600407. 1Q 1R02584 02S 007700201. 20 FOODJftR 12S 007800393. 9Q 1R03585 02S 007900297. 60 FOODJftR 12S 010000370. 50 1R03586 02S 010100220. 60 FOODJftR 12S 010200379. 70 1R03587 02S 010300268. 90 FOODJftR 12S 010400407. 10 1R02588 02S 010500303. 5Q FOODJftR 12S 010600400. 50 1R03589 02S 010700282. 50 FOODJftR 12S 010800248. 50 1R03590 02S 010900378. 30 F'-'-'DJftR 12S 011000256. 40 1. ,3591 02S 011100254. 50 FOODJftR 12S 011200411. 9Q 1R03592 02S 011200325. 40 FOODJftR 12S 011400276. 00 1R03593 02S 011500224. 00 FOODJftR 12S 011600391. 50 1R03594 02S 011700333. 40 FOODJftR 12S 011880358. 2Q 1R02595 02S 011900292. 20 FOODJftR 12S 012000398. 80 1R03596 02S 012100319. 50 FOODJftR 12S 012200368. 7Q 1R03597 02S 012300289. 6Q FOODJftR 12S 012408407. 1Q 1R03598 02S 012500355. 7Q FOODJftR 12S 012600384. 20 1R03599 02S 012700314. 50 FOODJftR 12S 012800371. 0Q 1R03600 02S 012900260. 40 FOODJftR 12S 013000416. 60 1R03601 02S 013100238. 8Q FOODJftR 12S 013200262. 3Q 1R03602 02S 013300285. 00 FOODJftR 12S 013400405. 1Q 1R03603 02S 012500308. 0Q F DJfiR 12S 013600288. 9Q 1R03604 02S 012700268. 0Q FOODJftR 12S 012800414. 20 1R03605 02S 012900286. 5Q FOODJftR 12S 014000398 6Q 1R03606 02S 014100304. 30 FOODJftR 12S 014200297. 9Q 1R03607 02S 014300343. 6Q 11 1 11 1 11 1 11 1 11 1 11 1 11 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2. 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 JJ/'. 7 324 382 364. 9 376. 7 371. 2 368. 2 349. 3 366. 1 345. 7 386 341. 6 367. 3 334. 3 370. 7 271. 5 406. 9 234. 9 407. 1 301. 2 393. 9 297. 6 370. 5 320. 6 379. 7 268. 9 407. 1 303. 5 400. 5 282. 5 ' 348. 5 378. 3 356. 4 254. 5 411. 9 325. 4 376 324 391. 5 333. 4 358. 2 292. 2 398. 8 319. 5 368. 7 289. 6 407. 1 355. 7 384. 2 314. 5 371 260. 4 416. 6 338. 8 362. 3 285 405. 1 308 388. 9 2 BEST COPY AVAILABLE 398. 6 304. 3 397. 9 343. 6 446 000834 FOODJAR 12 S 014400377. 00 1R0260S 02S 014500238. 60 FOODJAR 12S 014600255. 90 1R03609 02R 004600296. 40 FOODJAR 12S 014800271. 20 1R03610 02S 014900267. 70 FOODJAR 123 015000280. 40 r '6 02S 015100309. 70 F._ _,DJAR 12S 015200385. 90 1R03612 02S 015300318. 50 FOODJAR 123 015400394. 90 1R03613 023 015500276. 10 FOODJAR 123 015600367. 50 1R03614 023 015700308. 20 FOODJAR 123 015800274. 40 1R03615 023 015900297. 00 FOODJAR 123 016000378. 00 1R03616 023 016100306. 80 FOODJAR 123 016200287. 40 1R03617 023 016300306. 90 FOODJAR 123 816400387. 40 1R03618 023 016500327. 6Q FOODJAR 123 O16600368. 7Q 1R03619 02S 016700251. 50 FOODJAR 123 016800403. 00 1R03620 023 016900287. 60 FOODJAR 123 017000274. 30 1R03621 023 017100255. 60 FOODJAR 123 017200423. 80 1R03622 023 017300280. 30 FOODJAR 12S 017408402. 7Q 1R03623 02S 017500282. 30 FOODJAR 12S 017600287. 90 1 3624 023 017700293. 80 FOODJAR 123 017800393. 10 1R03625 023 017900239. 70 FOODJAR 123 018000399. 50 1FI03626 023 018108318. 50 FOODJAR 123 018200389. 60 1R03627 023 018300317. 90 FOODJAR 123 018400399. 20 1R02628 023 018500301. 50 FOODJAR 123 018600407. 70 1R03629 023 018700320. 90 FOODJAR 123 018800282. 60 1R03630 023 018900265. 00 FOODJAR 123 019000414. 50 1R03631 023 019100247. 70 FOODJAR 12S 019200289. IQ 1R03632 02S 019300312. 9Q FOODJAR 12S 019400396. IQ 1R03633 02S 019500233. IQ FOODJAR 12S 019600381. 20 1R03634 02S 019700223. 10 FOODJAR 12S 019800407. 00 1R03635 02S 019900221. 70 FOODJAR 123 020000294. 90 1R03636 023 020100322. 30 F '-DJAR 123 020200379. 90 li-.03637 023 020300284. 50 FOODJAR 123 020400274. 60 1R03638 023 028500274. 20 FOODJAR 123 020600386. 4Q 1R03639 023 020700282. 80 FOODJAR 12S 020800395. 0Q 1R03640 023 020900211. 3Q 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 377 338. 6 255. 9 296. 4 371. 2 367. 7 380. 4 309. 7 385. 9 318. 5 394. 9 376. 1 367. 5 308. 2 374. 4 297 378 306. 8 387. 4 306. 9 387. 4 337. 6 368. 7 251. 5 403 287. 6 374. 3 255. 6 423. 8 280. 3 402. 7 283. 3 387. 9 293. 8 393. 1 239. 7 399. 5 318. 5 389. 6 317. 9 399. 2 301. 5 407. 7 320. 9 383. 6 265 414. 5 347. 7 389. 1 312. 9 396. 1 333. 1 381. 2 223. 1 407 221. 7 394. 9 323. 3 379. 9 284. 5 374. 274. 386. 26 2 4 B11 EST COPY AVAILABLE 282. 8 395 211. 3 447 000835 1-UODJAR 12S 021000414. 80 1R03641 02S 021100330. 80 FOODJAR 12S 021200381. 60 1R03642 02S 021300269. 30 FOODJAR 12S 0214003:86. 60 1R03643 02S 021500327. 60 FOODJAR 12S 021600375. 60 : 3644 02S 021700269. 60 FijODJAR 12S 021800351. 90 1R03645 02 S 021900331. 20 FOOD JAF: 12S 022000371. 80 1R03646 03S 022100312. 50 FOODJAR 13S 022200396. 30 1R03647 03S 022300365. 00 FOODJAR 13S 022400384. 80 1R03648 03S 022500393. 00 FOODJAR 13S 022600341. 20 1R03649 03 S 022700359. 8Q FOODJAR 13S 022800369. 40 1R03650 03S 022900333. 70 FOODJAR 13S 023:000393. 20 1R03651 03 S 023100354. 50 FOODJAR: 13S 023200375. 90 1R03652 03 S 823300353. 8Q FOODJAR 13 S 023400386. Q 1R03653 03S 023500341. 80 FOODJAR 13S 023600379. 3Q 1R03654 03S 023700373. 5Q FOODJAR 13 023800377. 00 1R03655 03 S 023900370. 60 FOODJAR 13S 024000342. 40 1R03656 03S 024100358. 30 FOODJAR 13S 024200378. 00 1 3657 03 S 024300352. 90 FOODJAR 13S 024400388. 70 1R03658 03S 024500360. 30 FOODJAR 13S 024600385. 80 1R03659 03S 024700347. 30 FOODJAR 13S 024800379. 1Q 1R03660 03S 024900363. 80 FOODJAR 13S 025000369. 20 1R03661 03S 025100360. 20 FOODJAR 13S 025200379. 4Q 1R03662 03S 025300302. 40 FOODJAR 13S 025400396. 2Q 1R03663 03S 025500403. 60 FOODJAR 13S 025600343. 4Q 1R03664 03S 025700347. 60 FOODJAR 13S 025800386. 4Q 1R03665 03S 025900359. 7Q FOODJAR 13S 026000379. 0Q 1R03666 02S 026100364. 8P 1R03667 02S 026300279. 00 FOODJAR 13S 026400414. 4Q 1R03668 03S 026500281. 90 FOODJAR 13S 026600409. 7Q 1R03669 03S 026700355. 3Q F DJAR 13S 026800374. 1Q lk*s3670 03S 026900365. 50 FOODJAR 12S 027000360. 8Q 1R03671 03S 027100350. 90 FOODJAR 13S 027200377. 5Q 1R03672 03S 027300358. 6Q FOODJAR 13S 827400366. 60 1R03673 03S 027500339. 6Q 12 2 ei 12 2 12 2 12 2 12 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 3 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 3 13 3 13 3 13 3 13 3 13 3 13 3 414. e 330. 8 381. 6 269. 3 386. 6 32?. 6 375. 6 269. 6 351. 9 331. 2 371. 8 312. 5 396. 3 365 384. 8 393 341. 2 359. 8 369. 4 333. 7 393. 2 354. 5 375. 9 353. 8 386. 6 341. 8 379. 3 373. 5 377 370. 6 . 342. 4 358. 3 378 352. 9 388. 7 360. 3 385. 8 347. 3 379. 1 363. 8 369. 2 360. 2 379. 4 302. 4 396. 2 403. 6 343. 4 347. 6 386. 4 359. 7 379 364.8 279 414. 4 281. 9 409. 7 355. 3 g374. 1resi copym un 377. 5 358. 6 366. 6 339. 6 448 000836 h UUL'J MK l-i-8 ti2. tfcifcijyi.DU 1R03674 02S 02771110343. 00 FOODJRR 13 S 027800382. 80 1R03675 03S 027900378. 70 FOODJRR 12S 028008362. 40 1R83676 02S 028100404. IQ FOODJRR 128 028200358. 10 i ' 3677 038 0283010362. 20 Fi-j OJRR 138 028400361. 40 1R02678 02:8 028500367. 60 FOODJRR 128 028600378. 60 1R03679 039 028700371. 50 FOODJRR 138 028800366. 60 lRti3iSS0 028 028900373. 90 FOODJRR 138 029000361. 5Q 1R03681 03S 029100376. 10 FOODJRR 128 0292010362. 70 1R03682 03S 029300321. 00 FOODJRR 138 029400405. 50 1R036S3 038 029500382. 2Q FOODJRR 12S 029600359. 30 1R03684 028 029700366. 80 FOODJRR 128 029800352. 20 1R036S5 028 029900341. 70 FOODJRR 138 030000380. 30 1R0286 03S 030100339. 7Q FOODJRR 128 03:0200390. 70 1R03687 02S 030300341. 90 FOODJRR 138 030400371. 20 1R03<S88 038 FOODJAR 1R03689 038 030700321. IQ FOODJRR 12S 030800391. 30 1 3690 038 030900371. 8P FOODJRR 138 31000357. 40 1R03691 028 031100341. 5Q FOODJRR 138 031200386. 10 1R03692 038 031300300. 60 FOODJRR 138 031400413. 2Q 1R02693 03S 031500402. 7Q FOODJRR 13S 031600348. 80 1R03694 03S 031700256. 2Q FOODJRR 12S 031800362. 7Q 1R02695 03S 021900376. 40 FOODJRR 138 032000380. 3Q 99 13 3 13 3 13 3 12 3 13 3 13 3 13 3 13 3 12 3 13 3. 12 2 12 2 13 3 13 3 12 3 13 3 13 3 12 3 13 3 12 3 13 3 13 3 12 0 99 (. D 243 282. 8 378. 7 362. 4 404. 1 358. 1 362. 2 361. 4 267. 6 278. 6 371. 5 266. 6 273. 9 361. 5 276. 1 362. 7 221 405. 5 282. 2 359. 3 366. 8 352. 2 241. 7 380. 3 339. 7 290. 7 241. 9 371. 2 359. 7 367. 4 221. 1 391. 3 371. 8 357. 4 241. 5 286. 1 300. 6 412. 2 403. 7 248. 8 256. 2 362. 7 376. 4 380. 2 BEST COPY AVAILABLE 449 000837 TWO YEAR ORAL<DIET> TOX-ONC STUDY OF FM-2924 6. FC-143 IN RATS EXP. 0281CR0012 TECHNICIAN INITIALS:S MH TODAY S D A T E :S 6/2/81 SEX OF R A T S :S MALE ROOM N U M B E R :S D-340, D-238 WEIGHT OF FULL FOOD J A R :S 550GRAMS WEEK 6 1R03516 01S 000000421. ;<Q FOODJAR 11S 000100252. 6Q 1R03517 01S 000200387. 8G! FOODJAR 11S 000200265. 90 1R0351S 01S 000400385. 70 FOODJAR 11S 000500369. 80 1R03519 01S 000600421. 00 FOODJAR IIS 000700358. 20 1R03520 01S 000800410. 10 FOODJ AF: U S 000900360. 40 1R62521 01S 001000376. 30 FOODJAR IIS 001100272. 60 1R02522 eis 001200275. 90 FOODJAR n s 001200292. 80 1R03523 01S 001400426. 30 FOODJAR n s 001500318. 60 1R03524 01S 001600363. 90 FOODJAR IIS 001700385. 30 1 2525 01S 001800401. 10 FuoDJAR IIS 001900352. 10 1R02526 01S 002800384. 80 FOODJAR IIS 002100363. 50 1R03527 01S 002200389. 80 FOODJAR 11S 002300378. 90 1R03528 01S 002480414. 50 FOODJAR 15 002500360. 00 1R03529 01S 002600389. 10 FOODJAR IIS 002700329. 20 1R0353O 01S 002800396. 30 FOODJAR IIS 002900372. 20 1R03531 01S 003000386. 90 FOODJAR IIS 003100371. 20 1R03522 01S 002200390. 00 FOODJAR 11S 003300365. 70 1R03533 01S 003400409. 00 FOODJAR 11S 002500276. 60 1R03534 01S 003600432. 80 FOODJAR 11S 003700347. 70 1R03535 01S 803800241. 20 FOODJAR 11S 003900393. IQ 1R03536 01S 004000370. 70 FOODJAR 11S 004100286. IQ 1R03537 01S 004200350. 2Q FOODJAR IIS 004300366. 30 1 2538 01S 004400425. 60 FOODJAR 11S 004500350. 10 1R03529 01S 004600323. 9Q FOODJAR 11S 004700392. 60 1R03540 81S 04800364. 60 FOODJAR U S 004908375. 2Q 1R03541 01S 005000412. 50 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 421. 3 352. 6 387. 8 365. 9 2S5. 7 369. 8 421 358. 3 410. 1 360. 4 376. 2 372. 6 375. 9 392. 8 426. 3 318. 6 363. 9 385. 2 401. 1 352. 1 384. 8 363. 5 389. 8 378. 9 414. 5 360 289. 1 329. 3 396. 3 372. 2 386. 9 371. 2 390 365. 7 409 376. 6 432. 8 347. 7 341. 2 393. 1 270. 7 386. 1 350. 2 366. 3 425. 6 350. 323. 392. 1 9 6 BEST COPY AVAILABLE 364. 6 375. 2 412. 5 450 COO838 FOODJAR 119 003100228. 50 1R02542 013 005200397. 20 FOODJAR 11S 005300265. 20 1R03543 015 005400443. 80 FOODJAR 115 005500325. 20 1R03544 015 00560O384. 60 FOODJAR IIS 005700367. 00 1. 3545 01S 005800422. 10 FOODJAR U S 005900259. 60 1R02546 015 006O00420. 20 FOODJAR 115 006100371. 10 1R03547 015 6106200407. 10 FOOD JAR 115 006300247. 00 1R0354S 015 006400441. 10 FOODJAR 115 006500359. 4Q 1R02549 015 006600371. 00 FOODJAR 115 006700282. 3Q 1R03550 015 006800282. 10 FOODJAR 115 006900279. 70 1R03551 015 007000201. 10 FOODJAR 11S 0O7100408. SO 1R03552 015 007200403. 20 FOODJAR IIS 0073:00363. 90 1R02553 015 007400442. 70 FOODJAR 115 807500348. 90 1R02554 015 007600329. 80 FOODJAR 115 007700385. 00 1R03555 015 007800374. 00 FOODJAR 115 007900385. 90 1R03556 01S 008000421. 00 FOODJAR 115 008100380. 00 1R02557 015 008200382. 50 F DJAR 115 008300392. 70 1k 02558 015 008400326. 90 FOODJAR 115 1R02559 015 008600409. 10 FOODJAR 115 008700372. 40 1R02560 015 008800374. 20 FNMDJ0R 00R 008900279. 60 1R02561 015 009000435. 80 FOODJAR 115 09100248. 30 1R02562 015 009200329. 70 FOODJAR: 115 009300297. 20 1R:02563 015 009400368. 90 FOODJAR 115 009500385. 60 1R03564 015 009600364. 70 FOODJAR 115 009700374. 00 1R03565 01S 009800398. 70 FOODJAR 11S 009900346. 8Q 1R03566 01S 010000361. 3Q FOODJAR 115 1R03567 FOODJAR 11S 010300358. IQ 1R03568 015 010400404. 90 FOODJAR 11S 010500388. 70 1R02569 01S 010600409. 0Q FOODJAR 115 010700362. 20 3D03570 015 010800414. 2Q 1 JDJAR 11S 010900319. 00 1R03571 015 011000424. 6Q FOODJAR 115 011100340. 00 1R02572 015 011200396. 7Q FOODJAR 115 011300350. 9Q 1R03573 015 011400298. 50 FOODJAR IIS 811500368. IQ 1R03574 015 011600407. 4Q 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 s2ti. z> 397. 2 265. 2 443. S 335. 2 384. 6 367 422. 1 359. 6 420. 2 271. 1 487. 1 347 441. 1 359. 4 371 382. 2 382. 1 279. 7 301. 1 408. 8 402. 2 363. 9 442. 7 348. 9 229. 8 385 374 385. 9 421 380 382. 5 292. 7 326. 9 410. 1 409. 1 372. 4 274. 2 279. 6 425. 8 348. 3 229. 7 297. 3 368. 9 385. 6 364. 7 274 298. 7 246. 8 361. 3 397. 2 427. 0 358. 1 404. 9 388. 7 409 362. 2 414. 2 319 424. 6 340 296. 7 350. 9 298. 5 368. 1 407. 4 S I COPY AVAILABLE 45 000839 M JIJL'.'IIK H i - 011/00317. 8 0 1R03575 015 011800358 30 FOOC'JRF: 115 011900250 10 1R03576 015 012000387. 40 FOOC'JRF: 115 012100272. 40 1R02577 015 012200405. 10 FOOC'JRF: 115 012300361. 50 J ''02578 015 012400276. 40 1 .tC'JRF: 115 012500252. 20 1R03579 015 012600372. 70 FO O L1J HR 115 012700374. 10 0F:O35S0 0 1 5 0128003-66. 30 FOOC'JRF: 115 012900368. 30 1R03581 025 007100365. 30 FOOC'JRF: 125 007200360. 0 0 1R035S2 025 007300279. 40 FOOC'JRF: 125 00'7400422. 20 1R03583 025 00 7500242. 30 FOOC'JRF: 125 007600421. 20 1R03584 025 007700310. 50 FOOC'JRF: 12S 007800413. 0 0 1R03585 025 007900308. 90 FOOL'Th F: 125 010000388. 30 1R03586 025 010100333. 90 FOOL-'-JRF: 125 010200400. 80 1R035S7 025 010300281. 7 0 FOODJRR 125 010400434. 10 1R03588 025 010500328. 30 FOOC'JRF: 125 010600399. 80 1R03589 025 018700289. 20 FOOC'JRF: 125 010800382. 30 1R0359O 025 010900391. SO FOOC'JRF: 125 011000387. 2Q J 3591 025 011100269. 50 FuJDJRR 125 011200417. 10 1R03592 025 011300332. 60 FOOC'JRF: 125 011400392. 80 1R03593 025 011500338. 60 FOOC'JRF: 125 011600396. 30 1R03594 025 011700320. 40 FOOC'JRF: 125 011800406. 40 1R83595 025 011900300. 40 FOOC'JRF: 125 012000409. 80 1R03596 025 01210032-6. 40 FOOC'JRF: 125 012200397. 20 1P.03597 025 012300296. 20 FOOC'JRF: 125 012400426. 50 1R03598 025 012500350. 0 0 FOODJRR 125 012600432. 90 1R03599 025 012700308. 3Q FOODJRR 125 012800425. 40 1F;03600 025 012900263. 60 FOODJRR 125 013000440. 3Q 1R03601 025 012100348. 60 FOODJRR 125 013200398. 20 1R03602 025 013300292. 50 FOODJRR 12S 013400414. 60 1R03603 025 013500325. 30 Ff"-'C'JRR 125 013600403. 0 0 1 3604 025 013700278. 10 FOND JFIR 125 013800420. 0 0 1R03605 025 013900295. 80 FOODJRR 125 014008411. 90 1R03606 25 014100315. 30 FOODJRR 125 014200414. 40 1R03607 025 014300352. IQ 11 1 11 1 11 1 11 1 11 1 11 1 11 2 12 2 12 el 12 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 1e".12 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 317. 8 358. 3 350. 1 387. 4 373. 4 405. 1 261. 5 376. 4 352. 3 372. 7 374. 1 366. 3 368. 3 365. 3 368 279. 4 422. 3 242. 2 421. 2 310. 5 413 308. 9 388. 2 232. 9 400. 8 281. 7 434. 1 328. 3 299. 8 289. 2 382. 3 391. 8 387. 2 269. 5 417. 1 322. 6 292. 8 338. 6 396. 2 320. 4 406. 4 300. 4 409. 8 336. 4 397. 2 296. 2 426. 5 350 432. 9 308. 3 425. 4 263. 6 440. 3 348. 6 398. 2 292. 5 414. 6 325. 3 403 278. 1 420 295. 8 411. 9 315. 3 414. 4 352. 1 T COPY AVAILABLE 452 000840 MJUL'JHK 129 U144UtU90. lu 12 J9b. 1 1R0260S FOOL'JflR 023 123 014500353 014600376. I2 Q|Tl 1RO2609 023 014700207. 5Q 12 ie- 353. 1 376. 3 307. 5 FOODJflR 123 014800288. 2'Q 12 388. 2 IFFP:0m2[.:6.J1R0R 023 12S 014800174. 015000382. 5Q 8Q 2 12 374. 5 392. 8 1 611 023 015108315. 2Q 2 315. FOODJflR 123 015280344. 7Q 12 344. 7 1K02612 023 015200323. 0Q 323 FOOD'JAR 123 015400401. 60 12 " 403. 6 1R02612 023 015500281 20 2 391. FOuDJflR 123 015600381. 6Q 1R02614 023 01570326. 60 FOODJAF: 123 015800282. 5Q 2 "12 3:91. 6 I 326. 6 282. 5 1R03615 023 015880308. 2Q 2 309. 3 F OOl'JAR 123 016000282'. 1G 12 392. 1 1R03616 023 016100308. 8G FOOL'JflR 123 016200416. 9G 2 12 308. 8 416. 9 1R03617 023 816200317. 90 ei 317. 9 FOODJ0R 123 016400397. 80 12 397. 8 1R03618 02S 016500260. 40 2 360. 4 FOODJFlR 123 016600380. 60 12 380. 6 1R03619 023 016700263. 70 2 263. 7 FOODJFlR 123 016800413. 70 12 413. 7 1R03620 023 016900302. 20 2 302. 2 HOODJflR 123 017000404. 60 12 404. 6 1R03621 023 017100269. 40 2 269. 4 FOODJFlR 123 017200436. 70 12 436. 7 1R03622 023 017300284. 00 2 284 FOODJFlR 123 017400419. 70 12 419. 7 1F;03623 023 017500288. 10 2 288. 1 F "DJflR 123 017608411. 60 12 411. 6 1k 03624 023 017700295. 60 2 295. 6 FOODJFlR 123 017800415. 80 12 415. 8 1R03625 023 017900250. 70 2 250. 7 FOODJHR 123 018000426. 90 1R03626 023 018100332. 40 12 2 426. 9 333. 4 FOODJflR 123 018200407. 60 12 `407. 6 1FI03627 023 018300328. 60 2 228. 6 FOODJFlR 123 018400409. 70 12 409. 7 1R03628 023 018500306. 60 2 206. 6 FOODJFlR 123 018600431. 10 12 431. 1 IF;13628 023 018700331. 00 2 331 FOODJflR 123 018800404. 70 12 404. 7 1R0363O 023 018900271. 50 2 271. 5 FOODJFlR 02S 019000429. 80 12 439. 8 1R.03631 02S 819100227. 70 2 337. 7 FOODJflR 123 019200439. 30 12 439. 3 1R03632 02S 019300226. 00 2 226 FOODJflR 123 019400409. 00 12 409 1R02633 02S 019500346. 80 2 346. 8 FOODJflR 12S 019600411. 40 12 411. 4 1R03634 02S 019700239. 30 2 239. 3 FOODJflR 123 019800415. 80 12 415. 8 1R03635 023 019900220. 60 2 220. 6 FOODJflR 12S 020000442. 00 12 442 Jc'03636 023 020100241. 40 2 341. 4 JDJflR 123 020200399. 70 12 299. 7 1R02637 02S 020300286. 00 2 286 FOODJflR 123 020400407. 30 1R03638 023 020500262. 00 FOODJflR 123 020600419. 70 12 2 12 407. 3 284. 3 BEST COPY AVAILABLE 419. 7 1R03639 023 020700306. 00 2 306 FOODJflR 12S 020800403. 80 12 403. 8 1R03640 023 020900233. 2Q 2 233. 2 453 000841 MJUD-JHK X26 0 2 1 0 0 0 4 1 , - ' . U 12 4X f.6 1P03641 023 021100350. 00 2 350 FOODJRR 123 021200395. 90 12 395. 9 1P03642 023 021300268. 60 2 268. 6 FOODJRR 123 021400432. IQ 12 432. 1 1R03643 023 02150023S. 2Q _ 338. 3 FOODJRR 123 021600405. 90 12 405. 9 .1 c,03644 023 021700263. 00 2 263 , JDJRP 123 021300421. 20 12 1R03645 023 021900348. 30 2 FOODJRR 123 022000378.- 80 12 ** 421. 3 348. 7, 378. 8 1R 03-646 033 022100221. 40 3 321. 4 FOODJRR 133 022200487. 60 1R03647 025 022300381. 90 13 3 407. 6 381. 9 FOODJRR 133 022400293. 20 13 393. 2 0R03648 033 022500413. 10 3 413. 1 FOODJRR 133 022600358. 80 13 358. 8 1R03649 033 022700270. 10 3 370. 1 FOODJRR 133 022800382. 40 13 382. 4 1R03650 023 02290O350. 30 3 350. 3 FOODJRR 123 023000394. 50 13 394. 5 1R03651 023 023100378. 30 3 378. 3 FOODJRR 133 023200374. 90 13 374. 9 1R03652 033 022200365. 00 3 365 FOODJRR 123 023400385. 00 13 385 1R03653 023 023500373. 30 3 373. 3 FOOD JRF: 133 023600280. 80 13 380. 8 1R03654 023- 023708402. 60 2 403. 6 FOODJRR 133 023800374. 90 13 374. 9 1R03655 033 023900384. 20 3 384. 3 FOODJRR: 133 024800372. 10 13 372. 1 1R03656 023 024100395. 20 3 395. 2 FOODJRR 123 024200272. 30 13 372. 3 J '3657 033 024300369. 60 3 369. 6 F'.hJDJRR 123 024400392. 80 13 392. 8 1R03658 023 024500270. 80 3 370. 8 FOODJRR 133 024600407. 50 13 407. 5 1R03659 023 024700348. 70 3 348. ~7 FOODJRR 133 024800416. 60 1RO3660 033 024900386. 00 13 3 416. 6 386 FOODJRR 133 025000279. 20 13 379. 2 1R03661 023 025100365. 20 365. 2 FOODJRR 133 025200402. 60 13 402. 6 1R03662 023 025300314. 20 3 314. 2 FOODJRR 123 025400417. 20 13 417. 2 1R02663 03S 25500427. 10 3 427. 1 FOODJRR 133 025608371. 90 13 371. 9 1F:03664 02S 025700371. 40 3 371. 4 FOODJRR 13S 025800391. 20 13 391. 2 1R03665 03S 025900377. 0Q 3 377 FOODJRR 133 026008398. 8Q 13 398. 8 1R03666 023 026100380. 20 3 380. 2 FOODJRR 13S 026200384. 60 13 384. 6 1R03667 023 026300292. 9Q 3 292. 9 FOODJRR 133 026400420. 50 13 420. 5 1R03668 02S 026500289. 90 3 289. 9 FOODJRR 133 026600421. 10 13 421. 1 1R03669 033 026700371. 20 3 371. 2 FO-DJRR 133 026800289. IQ 13 289. 1 1. 3670 033 026908375. 00 FOODJRR 123 027080383. 60 1R03671 033 027100369. 10 3 13 3 375 383. 6 369. 1 BEST COPY AVAILABLE FONDJ0R 123 027200377. 60 13 377. 6 1R02672 023 027308378. 80 3 378. 8 FOODJRR: 133 027400390. 90 13 390. 9 1R03673 02S 027500336. 8Q 3 336. 8 454 000842 M JU D JH K l i i . U2i t > 0 0 4 2 y . in 1R02674 03 S 027700266. 0Q FOODJflR 12R 026800291. 3Q 1R02675 02S 027900391. 8Q FOOD-JAR 13 028000372. 3Q 1R02676 03S 028100434. 6Q FOODJAR 13 028200364. 3Q 1. 677 03S 0283003-57. 60 FOOD-JAR 135 028400403. 60 1R0267S 035 028500384. 70 FOODJAR 135 028600391. 90 1R03679 035 028700396. 20 FOOD-JAR 13 028800288. 80 1R03680 03 028900390. 70 FOOD-JAR 13 029000374. 40 1R02681 03 029100382. 10 FOODJAR 13 029200389. 00 1R03682 03 029300337. 70 FOODJAR 13 029400415. 20 1R03683 03S 029500399. 80 FOODJAR 12 029600376. 60 1R03684 03 829700277. 90 FOODJAR 13 029800371. 50 1R03685 03S 029900351. 9Q FOODJAR 13S 030000299. 00 1 R0 3 6 St* OS -- 03:0100355. 50 FOODJAR 13S 030200394. 60 1R03687 03 020300357. 90 FOODJAR 13 020400384. 50 1R03688 02 030500266. 60 FOODJ0R 02R 020600282. 8F'i 1R03689 FOOD^r J '2690 02S 030900380. 30 F.-.ODJAR 12 021000370. 90 1R03691 02 031100257. 10 FOODJAR 12 031200392. 5Q 1R03692 028- 031300307. 40 FOODJAR 13S 031400431. 60 1R03692 03S 031500420. 40 FOODJAR 13S 031600379. 10 1R03694 02S 031700382. 90 FOODJAR 12S 031800382. 90 1R03695 03S 021900390. 8Q FOODJAR 13S 022000290. 90 99 13 3. 12 J. 12 jji 13 3 12 13 3 13 12 *<; 12 12 3 13 3. 13 3 13 3 12 3 13 3 13 3 13 3 13 3 13 3 12 3 12 3 12 3 13 0 429. 1 366 291. 2 291. 8 372. 3 434. 6 364. 3 257. 6 403. 6 384. 7 391. 9 396. 2 388. 8 390. 7 374. 4 282. 1 289 327. 7 415. 2 399. 8 276. 6 377. 9 371. 5 351. 9 399 355. 5 294. 6 257. 9 384. 5 366. 6 383.8 319.9 412.2 280. 3 370. 9 257. 1 392. 5 207. 4 431. 6 420. 4 379. 1 382. 9 382. 9 390. 8 390. 9 BEST COPY AVAILABLE 455 000843 TWO YEAR U R A L D I E T > TOX-ONC STUDV OF FM-2924 6. FC-143 IN RATS EXP. # 0281CR0012 TECHNICIAN INITIALS:S MH TODAY'S D A T E :S 6/9/81 SEX OF R A T S :S MALE ROOM NUMBER :S D-340, 0.-228 WEIGHT OF FULL FOOD J A R :S 550GRAMS WEEK 1R02516 01S 00 7100434. 70 FOOD JAR 11S 007200346. 80 1R02517 01S 0073:00400. 00 FOODJAR 11S 887400361. 20 1R02518 01S 007500399. 60 FOODJAR 11S 007600347. 50 1R03519 01S 00 7700434. 70 FOODJAR 11S 007800353. 60 1R02520 01S 007900420. 20. FOODJAR IIS 010000348. 30 1R02521 01S 010100280. 80 FOODJAR IIS 010200376. 00 1R03522 01S 0103<00392. 00 FOODJAR 11S 010400278. 60 1R02523 01S 010500442. 10 FOODJAR 11S 010600330. 20 1R02524 01S 010780382. 60 FOODJAR 11S 010800371. 40 1 3525 01S 010900378. 00 FOODJAR 11S 011000315. 80 1R03526 01S 011100399. 20 FOODJAR 11S 011200331. 20 1R02527 01S 011200401. 90 FOODJAR IIS 011400378. 10 1R03528 01S 011500424. 70 FOODJAR 11S 811600334. 00 1R03529 01S 011700399. 80 FOODJAR IIS 011800368. 30 1R03530 01S 011980413. 60 FOODJAR 11S 012000356. 70 1R03521 eis 012100402. 0Q FOODJAR 11S 012200363. 80 1R02532 01S 012300411. 20 FOODJAR IIS 012400263, 2Q 1R03533 01S 012500427. 90 FOODJAR 11S 012600362. 5Q 1R03534 01S 012700445. 80 FOODJAR 11S 012800243. 30 1R02535 01S 012900356. 0Q FOODJAR 11S 012000392. 50 1R03536 01S 012100375. 00 FOODJAR 11S 012200293. 2Q 1R03537 01S 013200360. 30 F`- -DJAR IIS 013400369. 50 1.-2538 01S 012500447. 20 FOODJAR 11S 013600352. 70 1R02535 01S 013700342. 90 FOODJAR 11S 012800384. 9 0 1R03540 01S 013900280. 30 FOODJAR 11S 014000371. 80 1R03541 01S 014100428. 30 FOODJAR 11S 0 1 4 2 0 0 3 6 0 . 6Q 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1' 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 434. 7 246. 8 400 361. 2 399. 6 347. 5 434. 7 353. 6 420. 2 248 3 380. 8 376 392 278. 6 442. 1 230. 2 . 382. 6 271. 4 378 315. 8 399. 3 321. 2 401. 9 378. 1 `424. 7 334 399. 8 368. 3 413. 6 256. 7 402 363. 8 411. 2 362 427. 9 362. 5 445. 8 243. 3 356 292. 5 375 293. 2 360. 3 369. 5 447. 2 252. 7 342. 9 384. 9 380. 3 371. 8 BEST COPY AVAILABLE 428. 3 360. 6 456 000844 1R03542 01S 014300408 00 FUOD JFtF' IIS 014400360. 90 1R62542 01S 014500453. 20 FOODJflR n s 014600226. 40 1R03544 01S 014700402. 20 FOODJFlR IIS 014800362. 70 lr 2545 01S 014900422. 50 F.. _.DJflR lis 015000356. 30 1R07546 01S 015100434. 90 FOOD JflR n s 015200370. 00 1R02547 01S 015300426. 50 FOODJFlR lis 015400313. 60 1R02548 01S 015500457. 60 FOODJFlR lis 015600328. 30 1R03549 01S 015700384. 00 FOOD JRF' lis 015800388. 30 1R03550 01S 015900399. 00 FOODJFlR; lis 016000366. 70 1R02551 01S 016100312. 20 FOODJFlR lis 016200408. 50 1R03552 01S 016300416. 20 FOODJFlR lis 016400355. 30 1R02553 01S 016500456. 90 FOODJFlR lis 016600317. 40 1R03554 01S 016700333. 90 FOODJFlR lis 016800352. 80 1R03555 01S 016900390. 20 FOODJFlR lis 017000355. 90 1R03556 01S 017100427. 30 FOODJFlR lis 117200313. 60 1R02557 01S 017300397. 40 FOODJFlR lis 017400384. 60 1 2558 01S 017500338. 70 FOOD JflR; lis 017600368. 10 1R03559 01S 017700422. 40 FOODJFlR lis 017800373. 60 1R0256O 01S 017900380. 40 FOODJflR lis 018000377. 60 1R03561 01S 018100452. 90 FOODJFlR lis 018200327. 40 1R03562 01S 0183-00343. 90 FOODJflR lis 018400389. 50 1R03563 01S 018500379. 10 FOODJFlR lis 018600382. 00 1R03564 01S 018700373. 90 FOODJFlR lis 018800351. 1Q 1R03565 01S 018900412. 00 FOODJFlR lis 019000373. 7Q 1R03566 01S 019100373. 20 FOODJFlR lis 019200375. 70 1R03567 01S 019300434. 30 FOODJFlR lis 019400353. 8Q 1R03568 01S 019500428. 40 FOODJFlR lis 019600361. 90 1R03569 01S 019700421. 30 FOODJFlR lis 019800354. 20 1R03570 01S 019900432. 2Q F"-DJflR lis 020000325. 60 1, ...2571 01S 020100445. 50 FOODJFlR lis 020200342. 00 1R03572 01S 020300414. 80 FOODJFlR lis 020400353. 10 1R03573 01S 020500421. 50 FOODJFlR lis 020680361. 30 1R03574 01S 020700417. 9Q FOODJFlR lis 020800313. 30 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 4@S 360. 9 453. 2 336. 4 402. 2 362. 7 432. 5 356. 3 434. 9 370 426. 5 313. 6 457. 6 328. 3 384 388. 3 399 366. 7 312. 2 408. 5 416. 2 355. 3 456. 9 317. 4 333. 9 352. 8 390. 2 355. 9 427. 3 313. 6 397. 4 384. 6 338. 7 368. 1 422. 4 373:. 6 380. 4 377. 6 452. 9 327. 4 343. 9 389. 5 379. 1 382 373. 9 351. 1 412 373. 7 373. 2 375. 7 434. 3 353. 8 428. 4 361. 9 421. 3 354. 2 432. 2 325. 6 445. 5 342 B S T copy available 421. 5 361. 3 417. 9 313. 3 457 000845 1R02575 01 S G20900275. 70 FOGDJflR IIS 021000334. 00 1R03576 01S 021100399 80 FOGDJflR 11 s 021200331. 70 1R02577 GIS 021300423. 50 FuODJflR H'S 0214G0350. 10 lr '578 01S 021500384. 60 F_-DJflF: IIS 021600354. 90 1RG2579 01S 021700387 60 FGOL* JflF: IIS 021800362.. 50 IF'G7580 01S 021900379. 30 FGOD JAR: IIS 022000369. 90 1R02581 02S 007100387. 30 FOODJAR 12S 007200355. 70 1R03582 02S 00730294. 40 FOGDJflR 12S 00"'400399. 70 IF:GI-582 02S 007500258. 00 FOGDJflR 12S 007600405. 20 1R02584 028 00 7700328. 90 FOGDJflR' 12S 007800377. 80 1R02585 02S 007'900325. 30 FOGDJflR 12S 010000381. 20 1R035S6 G2S 010100348. 20 FOGDJflR 12S 010200385. 40 1R02587 02S 01G300297. 70 FOODJAR 128 .18400411. 20 1R035S8 028 010500246. 20 FOGDJflR 128 010600383. 00 1R03589 028 010700305. 60 FOGDJflR 128 010800258. 10 1803590 028 010900407. 10 FOGDJflR 128 011000370. 80 1 2591 028 011100277. 10 FOGDJflR 128 011200400. 60 1ft0259c- 028 011300365. 30 FOODJflR 128 011400379. 00 1R02592 028 011500354. 20 FOGDJflR 128 011600381. 20 1R03594 028 0117003561. 90 FOODJflR 128 @113610377. 20 1R03595 028 011900310. 80 FOGDJflR 129 012000393. 80 1R03596 028 012100359. 20 FOGDJflR 128 012200363. 60 1R03597 028 012300318. 70 FOGDJflR: 128 012400392. 10 1R03598 028 012500378. 80 FOODJRR 128 012600363. 60 1R02599 028 012780339. 60 FOODJflR 12S 012800361. 3Q 1R026O0 02S 012900285. 50 FOODJflR 125 013000407. 0Q 1R03601 02S 013100365. 30 FOODJflR 12S 013200373. 00 1R03602 02S 013300315. 10 FOODJflR 12S 013400406. 90 1R03603 028 013500345. 00 F '" "OJflR: 128 013600380. 60 li -3604 028 013700288. 90 FOGDJflR 128 013800416. IQ 1R:03605 02S 013900304. 70 FOODJflR 128 014000400. 50 1R02606 028 014100327. 50 FOGDJflR 128 014200407. 60 1R02607 02S 014300354. 7Q FOODJflR 12S 014400396. 50 1 11 1 11 1 11 1 11 1 11 1 11 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 375. 7 334 331. 8T1 423. 5 350. 1 384. 6 354. C| 3:87. to 362. 5 379. j. 369. 9 387. 355. 7 294. 4 399. 7 258 405. 2 328. 9 377. 8 325. 3 381. 2 348. 2 385. 4 297. 7 411. 2 346. 2 383 305. 6 358. 1 . 407. 1 370 277. 1 400. 6 365. 3 379 354. 2 .381. 2 350. 9 377. 2 310. 8 393. 8 359. 2 363. 6 318. 7 392. 1 378. 8 363. 6 339. 6 361. 3 285. 5 407 365. 3 373 315. 1 406. 9 345 380. 6 288. 9 416. 1 304. 7 400. 5 BEST COPY AVAILABLE 327. 5 407. 6 354. 7 396. 5 458 000846 1R02 608 014500376. 20 FOODJAR 128 014600363. 00 1R03609 02S 014700323. 2 0 FOODJAF: 1 2 S 014800378. 30 1R03 610 2S 014900388. 00 FuOD JflF: 12S 015000385. 20 lr "2611 02S 015100322. 40 F._ ..L'Jh F 1 2 S 015200384. 60 IF:2 612 0 2 ? 115200246. 10 FOODJAF' 1 2 S 0154 00287. 00 1R02612 0 2 ? 015500410. 50 FOOD JflF' 128 015600285. 40 1R02614 0 2 ? 15700355. IQ FOODJAR 1 2 S 015800362. IQ 1R02615 0 2 ? 015900323. 10 FOODJAR 1 2 S 016000368. 80 1R03616 02S 016100231. 20 FOODJHR 1 2 S 016200390. 20 1R03617 0 2 S 816300316. 80 FOOD JflF: 1 2 S 016400314. 10 1R03618 0 2 ? 016500378. 30 FOOD JflF: 12S @1?*SQ@5:70. 8 Q 1R03619 0 2 ? 816700288. 50 FOOD JflF: 12S 016800401. 10 1R82620 02S Q1 if:h 0 m 327. 7Q, FOODJAR 1R03621 02S 017100292. 10 FOOD JflF: 12S 017200405. 70 1R03622 028 017300302. 70 FOOD JflF: 128 017400410. 60 1R03622 0 2 S 017500317. 00 FOODJAR 12S 017600375. 50 1 3624 0 2 ? 017700321. 50 FOODJAR 12S 017800392. 90 1R03625 0 2 S 017900244. 10 FOODJAR 12S 018000396. 60 IF:02626 0 2 ? 018100351. 50 FOOD JflF' 1 2 S 018200291. 70 1R03627 0 2 ? 018300344. 20 FOODJAR 129 018400388. 60 1R03628 0 2 ? 018500333. 50 FOOD JflF: 1 2 S 018600393. 70 1R02629 029 018700357. 50 FOODJAR 129 018800382. 10 1R02'630 029 018900275. 60 FOODJAR 129 019000434. 00 1R03631 029 019100379. 7Q FOODJAR 129 019200346. 7Q 1R03632 029 019200345. 7Q FOODJAR 129 819400383. 10 1R03633 0 2 S .19500375. 90 FOODJAR 129 019600361. 60 1R03634 0 2 S 019700262. 90 FOODJAR 1 2 S 019800400. 80 1R03635 029 019900255. 90 FOODJAR 129 020000385. 60 1R02636 029 20100360. 50 F" -'DJAR 129 020200382. 00 1.-337 0 2 ? 020300213. 70 FOODJAR 129 020400378. 10 1R03638 029 020500303. 30 FOODJAR 129 020600391. 7Q 1R03639 029 020700228. 40 FOODJAR 129 020800387. 50 1R0364O 029 020900246. 20 FOODJAR 129 021000409. 20 2 12 ai 12 C~ 12 y 12 2. 12 2 12 2 12 e12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 1"ii2 Sm 1C--N2 12 2 12 2 1CO.2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 276. 2 -i6i 322. 2 388 385. 4 384. 6 346. 1 387 410. 5 385. 4 355. 1 362. 1 323. 1 368. 8 331. 2 390. 2 316. 8 314. 1 378. 3 370. 8 288. 5 401. 1 323. 7 357. 3 292. 1 405. 302. 7 410. 6 317 375. 5 331. 5 392. 9 244. 1 396. 6 351. 5 391. 7 344. 2 388. 6 333. 5 393. 7 357. 5 382. 1 275. 6 434 379. 7 346. 7 345. 7 383. 1 375. 9 361. 6 262. 9 400. 8 255. 9 385. 6 360. 5 382 313. 7 378. 1 303. 3 391. 7 328. 4 387. 5 246. 2 409. 2 BEST COPY AVAILABLE 459 000847 1R03641 023 02110O359 80 FU D JftR 1 2 121200395. 50 1R03642 0 2 S 021300290. 40 FOODJHR 1 2 S 0214O0422. 20 IF:03 8 43 02S 0215O0350. 10 FOODJHR 1 2 021800392. 30 lr ''3644 02S 021700295 80 F._ -,DJHR 1 2 0 218 O0371. 90 1R03645 CCS C21?CiCC82. 2Q FOODJHR 12S 022000358!. 1 0 1R03646 CCS 022100335. 80 FOODJAR 13 022200397. 60 1R03647 CCS Ci222-0CC'92. 80 FOODJHR 138 022400379. 80 1R03648 03S 022500438. 10 FOOD-JAR 13 022600374. 90 1R03649 03 022700391. 30 FOODJHR 12S 022800367. 20 1R03650 03 S 0225*00368. 20 FOOD JftR 13 S 023000392. 50 1R03651 03 S 023100387. 40 FOODJHR 13S 023200388. 90 1RCC652 03 S 023300375. 60 FOODJHR 13 S 823400362. 40 1R@3*S53 3 S 023500385. 90 FOODJAR 13S 023600382. 00 1R03654 03S 02370O422. 80 FOODJAR 13S 023800364. 80 1R03655 03 S 023900405. 50 FOOD1JHR 13S 024000341. 70 1R03656 03S 024100408. 30 FOODJHR 13S 824200367. 90 1 3857 03 S 024300389. 20 FOODJHR 13S 024400355. 9Q. 1R03658 FOODJHR 13S 024600387. 60 lRCC'i*5S* 03 024700357. 40 FOODJHR: 13S 024800384. 10 1R03680 03S 824900410. 00 FOODJHR 13S 025000371. 70 1R03681 03S 025100389. 30 FUODJAR 13 025200374. 80 1R.03662 03 S 025300320. 50 FOODJHR 135 025400406. 60 1R03883 CC-S 025500445. 00 FOODJHR 025680369. 9Q 1R03664 03 025700379. 80 FOODJHR 13S 025800385. 70 1R03865 03S 025900398. 50 FOODJHR 13S 026000373. 90 1FI03666 03S 026100389. 4Q FOODJHR 13S 026200377. 60 1R03667 03S .26300308. 80 FOODJHR 13S 026400401. 7Q 1R03668 03S 026500308. 70 FOODJHR 13S 026600406. 20 1R03669 03 .26700368. 50 F''DJHR 13S 026800380. 7Q li --3670 03S 026900385. 70 FOODJHR 13 027000374. 20 1R03671 03 S 027100368. 90 FOODJHR 135 027200376. 50 1R03672 035 027300392. 90 FOODJHR 135 027400380. 60 1R03873 03S 027500350. 60 FOODJHR 13S 027600390. 6 Q cL 12 2 12 2 12 y 12 12 J13 13 3 13 3 13 3 13 3 13 3 13 3c 13 3 13 3 13 313 3 13 3 13 3 13 3 -1J3 13 3 13 3 13 3 13 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 359 S 395. 5 290. 4 422. 2 350. 1 295. 8 371. 9 382. 2 358. 1 335. 6 3:97. 6 393. 8 379. 8 430. 1 374. 9 391. 3 367. 2 368. 2 392. 5 387. 4 388. 9 375. 6 362. 4 385. 9 382 422. 8 364. 8 405. 5 341. 7 408. 3 367. 9 389. 2 355. 9 380. 5 387. 6 357. 4 384. 1 410 371. 7 389. 3 374. 8 320. 5 406. 6 445 369. 9 379. 8 385. 7 398. 5 373. 9 389. 4 377. 6 308. 8 401. 7 308. 7 406. 2 368. 5 380. 7 385. 7 BEST COPY AVAILABLE 374 2 368. 9 376. 5 392. 9 380. 6 350. 6 390. 6 460 C00848 1R03674 0 3 0i 7 70028:7. 00 FOODJRR 027800280. 70 1R02675 028 027900416. 80 FOODJRR 12 028000352. 10 IF'016 76 03 028100452. 20 FOODJRR 13S 028200255. 10 lr ''677 03 28300277. 80 F: .-DJRR 12 S 028400384. 60 1R03678 03S 028500404. 50 FOODJRR 12 028600394. 40 1802679 03 028700415. 20 FOOt> JRR 12 028800375. 50 1R03688 03 028900407. 20 FOODJAR 1R03681 02 029000403. 20 FOODJRR 12 029100366. 50 1R03682 02 029200348. 90 FOODJRR 12 029300407. 50 1R03683 02 029400423. 40 FOODJRR 12 029500359. 20 1R03684 02 029600401. 50 FOODJRR 13 029700371. 50 1R03685 02 029800367. 80 FOODJRR 13 029900380. 80 1R03686 02 .20000368. 60 FOODJRR 12 030100403. 10 1R03687 02 020200375. 60 FOODJRR 13S 030300365. 70 1R03688 02 030400385. 20 FOODJRR 12 030500376. 20 1R03689 02 030600325. 10 FOODJRR 12 030700403. 30 1 3690 03 020800389. 00 FOODJRR 13S 020900290. 30 1R03691 02 021000357. 20 FOODJRR 13S 021100364. 20 1R03692 03 021200312. 10 FOODJRR 13 021300372. 50 1R02693 02S 031400428. 00 FOODJRR 13 S 021500358. 50 1R03694 03S 021600400. 80 FOODJRR 13S 021700266. 90 1R03695 03S 031800412. 30 FOODJRR 13S 021900281. 50 99 12 2 12 3 12 2 12 2 12 2 13 3 13 3 13 2 12 3 12 2 13 2 12 2 13 2 13 3 13 3 12 3 12 3 13 2 13 3 13 3 12 3 12 0 287 380. 7 416 8 352. 1 452. 3 355. 1 377. 8 384. 6 404. 5 394. 4 415. 2 375. 5 407. 2 365.1 403. 2 366. 5 348. 9 407. 5 423. 4 359. 2 401. 5 371. 5 367. 8 380. 8 368. 6 403. 1 375. 6 .365. 7 385. 2 276. 2 225. 1 403. 3 389 290. 2 257. 2 264. 2 212. 1 372. 5 438 358. 5 400. 8 266. 9 412. 2 381. 5 BEST COPY AVAILABLE 461 C00849 TWO YEAR O R AL<D I ET> TOX-ONC STUDV OF FM-2924 & FC-143 IN RATS EXR. # 0281CRO812 TECHNICIAN INITIALS: MH TODA Y-'S DATE -.S 6/16X61 SEX OF R A T S :S MALE ROOM N U M B E R :S D-240, D-228 WEIGHT OF FULL FOOD JAR::S 550GRAMS WEEK 8 1R02516 01S 00?100462. 90 FOOD JAR 11S 00?200358. 00 1R0351? 01S 00 7200426. 2G! FOODJAR 11S 007400276. 20 1R02518 01S 007500419. 00 FOOD JAR 11S 007600366. 90 1R03519 01S 0O7700455. 60 FOOD JAR: 11S 007800272. 40 1R02520 01S 007900437. 90 FOODJAR 11S 010000280. 20 1R02521 01S 010100400. 80 FOODJAR 11S 010200274 30 1R02522 01S 010300408. 20 FOOD JAR. 115 010400387. 50 1R02523 01S 010500473. 70 FOODJAR 11S 010680267. 60 1R02524 01S 010700412. 50 FOODJAR 11S 010800271. 70 1 2525 01S 010900422. 40 FuuDJAR 11S 011000352. 20 1R03526 01S 011100428. 7G! FOODJAR 11S 011200363. 80 1R02527 01S 011300420. 10 FOODJAR 11S 011400282. 60 1R03528 01S 011500451. 70 FOODJAR lis 011600358. 50 1R02529 01S 011700419. 30 FOODJAR 11S 011800363. 10 1R02530 01S 011900444. 90 FOODJAR 11S 012000260. 20 1R02521- 01S 012100427. 90 FOODJAR 11S 012200271. 60 1R03522 01S 012300422. 80 FOODJAR 11S 012408378. 20 1R02532 01S 012500464. 80 FOODJAR 11S 012600352. 10 1R03524 01S 012700477. 40 FOODJAR 11S 012800241. 30 1R02535 01S 012900380. 00 FOODJAR 11S .13000381. 00 1R02536 01S 013100393. 00 FOODJAR 11S 013200397. 30 1R03537 01S 0133003/4. 40 F, DJAR 11S 012400377. 90 1R03538 01S 013500485. 90 FOODJAR 11S 013600343. 70 1R03539 01S 013700263. 40 FOODJAR 11S 013300386. 0Q 1R03540 01S 012900298. 10 FOODJAR 11S 014000271. 80 4 rirt**/er a a n >A r r * A a a a r-e* -*i"i l li i li i li l li i li l li l li i 11 l li l ii l ii i ii i ii i ii l ii i ii l ii l ii i ii l ii i ii l ii l ii i ii l ii A 463. 9 258 426. 2 276. 2 419 366. 9 455. 6 272. 4 437. 9 380. 2 400. 8 374. 3 408. 2 287. 5 473. 7 367. 6 412. 5 271. 7 422. 4 352. 2 428. 7 362. 8 420. 1 282. 6 451. 7 258. 5 419. 3 362. 1 444. 9 360. 2 427. 9 271. 6 422. 8 378. 2 464. 8 252. 1 477. 4 341. 3 380 381 393 397. 3 374.4 277. 9 485. 9 243. 7 363. 4 286 BEST COPYAVAILABLE 398. 1 271. 8 -rfCER ^ 462 000850 f-UOD JAF' U S 014200358- 20 1R03542 018 0142 00438. 7Q FOOD JHR U S 014400387. 80 1R03543 018 014500484 80. FOODJAR U S 014800321 50 1R03544 01S 014700434. 70 F r,JHF U S 014800322. 40 It,.'3545 01S 014800482. 30 FOODJAR U S 015000348. 10 lRti3546 01S 015100457, 80 FOODJHR U S 015200347. 10 1R03547 01S 015200457. 90 FOODJAF: U S 015400237. 80 1R03548 IS 0155001487 20 FOODJflR U S 015800351. 40 1R03549 01S 015700403, 40 FOOD JAR U S 015800390. 20 1RO2550 01S 015900417. 50 FOODJAR U S 01180001375. 50 1R03551 01S 018100328. 00 FOODJAR U S 0182001410. 80 1R02552 01S 0118300447. 10 FOODJAR U S 018400251. 60 1R02552 01S 016500494. 20 FOODJAR U S 016800332. 0iQ 1R03554 01S 0167010353. 60 FOODJAR U S 0168010393. 60 1R02555 01S FOODJAR U S 017000378. 80 1R03556 01S 0171010467. 10 FOODJAR U S 017200264. 80 1P03557 01S 017300422. 60 F D-JAR U S 017400380. 90 1R0255S 01S 017500259. 40 FOODJAR U S 017600284. 00 1R02559 01S 011770101453. 70 FOODJAR U S 0178010269. 40 1R:02:580 01S 017900395. 50 FOODJAR! U S 01180100385. 60 1R83561 01S 0118100480. 00 FOoDJAR U S 0118200329. 90 IF'03 50 2 01S 018200350. 80 FOODJAR U S 018400395. 10 1R03563 01S 01850014010. 10 FOuD JAF! 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O 1R02578 03 S '28500426. 70 FOODJFIR: 13S '286002.86. 70 1R02579 03S 028700446. 90 FOODJftR 12 S 028800241. 30 1R035S0 02S '28900433. 60 FOODJftR 13S '9000360. 90 1R02581 02S 0291'042'. 60 FOODJftR. 13S 29200260. 70 1R02582 02 S 029300362. 10 FOODJftR 12S '29400400. 50 1R02583 03 029500451. 50 FOODJftR 13 S 029600355. 60! 1R02584 03 S '9700429. 90 FOODJftR 13S 029800359. 20 1R02585 03S '29900383. 40 FOODJftR 12S 030000377. 50 1R02586 03 S 030100293. 60 FOODJftR 12 S 020200383. 30 1R02587 02S 020200402. 40 FOODJftR 12 020400356. 50 1R035S8 03 '2:0500415 86 FQODJftR 13 030600362. 20 1R03589 02 '30700247. 20 F DJftR 12 020800299. 20 1R0359 02 030900424. 40 FOODJftR 12 031000247. 10 1R02591 02 031100283. 20 FOODJftR 12 031200375. 30 1R02592 02 S 031200336. 60 FOODJftR 12 031400291. 80 1R03593 03 FOODJftR 13 031600242. 80 1R02594 03 021700428. 20 FOODJftR 12 031800346. 70 1R03595 02S 021900441. 40 FOODJftR 13S 032000362. 00 12 Jj. 12 13 3 13 "<. 13 jj. 13 3 13 12 13 13 3 1-3 3 13 3 13 3 13 13 13 J. 13 3 13 3 13 3 13 3 13 3 12 3 12 373. 4 414 270. 9 441. 2 355. 5 475. 8 342. 3 412. 8 358 426. 7 386. 7 446. 9 341. 3 432. 6 260. 9 432. 6 360. 7 362. 1 400. 5 451. 5 355. 6 429. 9 259. 2 383. c4; . i i . --* 393. 6 383. 3 402. 4 356. 5 415. 8 462. 2 347. 2 299. 2 424. 4 347. 1 383. 2 375. 2 236. 6 291. 8 481.8 242. 8 BEST Copy AVAILABLE 428. 2 246. 7 441. 4 362 46/ G00S55 TWO YEAR O P A L D I E T T O X - O N C STUDY OF FM-2924 S, FC-143 IN RATS EXP. # 0281CR0012 TECHNICIAN INITIALS:S MH TODAY S D A T E :S 6/22/81 SEX OF P A T S :S MALE ROOM N U M B E R :S D-240, D-238 WEIGHT OF FULL FOOD J A R :S 550GRAMS WEEK 9 1R02516 01S 007100485. 7Q FOODJAR 11S 007200257. 0Q 1R2517 01S 00 730043S. 50 FOOD JAP. 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FOUL'JHF 126 021000406. 70 1R03641 02b 021100402. 90 FOOL'Jh F: 1x6' 021200379. 80 1F:0364x 02S 021200249. 60 FOOL1JRF: 12b 021400275. 50 1R02642 02 021500297. 00 F ''iL'JRF: 12b 021600383. 80 x. .02644 02 b 021700227. 60 FOOD JRF' 12S 021S0O382. 70 IR02 640 Ox'S 21900438. 40 FOOL'JRF: 12 022000247. 50 1R03646 02 b 022100262. 10 FOOL'JRR 13 022200391. 20 1RGI2647 03 022300437. 90 FOOL'JRR 13 022400386. 40 1R03648 03 022500492. 00 FOODJ RF: 12S 022600338. 90 1R03649 02 022700443. 60 FOODJRR 12 022800252. 10 j_F0 2620 03S 0229610404. 60 FOOL'JRF: 12 0230061386. 90 1R02651 02 0221610427. 70 FOOL'JRR. 12 023200276. 10 1R83652 02' 023300418. 30 FOOL1JRF: 12 023400372. 50 lR:yx65 03 023500425. 20 FOODJftR 12 023:66103-67. 60 1R02654 02 022700463. 20 FOOL1JRF: 13 6i23800359. 20 1R02655 03b 61239610455. 20 FOOL'JRR 13S 0240061232. 20 1R03656 02 024100450. 50 f OJRF: 123 024208366. 10 1R02657 02: 0243061433. 50 FOOL'JRR 12S 0244610364. 00 1R03653 02 024500415. 80 FOOL'JRR 12 024600384. 70 1R02659 06 b 02470046i7. 90 FOOL-JRR 12 024800267. 40 1R03660 03 024900456. 10 FOOL'JRR 13 025000346. 80 IF:026*6.1 02 0251610429. 30 FOOL'JRF: 13 S 025200367. 10 1R613662 @2 025300341. 60 FOODJRR 13 025400416. 00 1R03662 03S 025500485. 60 FOOL'JRR 13S 025600355. 30 1R03664 03S 025700392. 70 FOODJRR 12S 025800408. 50 1R03665 02S 025900432. 80 FOOL'JRR 13S 026000374. 40 1R03666 03S 026100423. 4Q FOODJRR 12S 026200369. 40 1R03667 02S 026300226. 00 FOODJRR 12 026400404. 70 1R03668 02S 026500331. 80 FOODJRR 13 026600424. 80 J' "12669 02S 026700438. 00 F ..jDJRR 13S 612686*0359. 30 J.R03670 03 026908444. 80 FOOL'JRR 13 6127000335. 40 1R02671 02S 027100415. 00 FOODJRR 13S 027'200354. 50 1R03672 03 027300442. 00 FOOL'JRR 13 02746*0360. 80 12 2 12 2 12 cL 12 2 12 2 12 3 13 s 13 3 13 3 13 3 13 3 13 jj! 13 2 13 13 2 13 3 13 13 3 13 J 13 3 13 3 13 j, 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 12 3 13 271 46*6. 7 403. 379. 8 349. 6 375. 5 397 383. 8 337. 6 282. ^7 438. 4 347. 5 362. 1 391. 2 437. 9 386. 4 492 338. 9 443. 6 352. 1 404. 6 386. 9 427. 7 376. 1 . 418. 2 372. 5 425. 2 267. 6 462. 2 359. 2 455. 2 322. 2 450 5 366. 433. 1Cj 364 415. 8 384. y ' 407. 9 367. 4 456. 1 346. 8 429. 3 367. 1 341. 6 416 485. 6 355. 2 393. 7 408. 5 432. 8 374. 4 423. 4 369. 4 326 404. 7 BEST COPY AVAILABLE 331. 8 424. 8 438 359. 3 444. 8 335. 4 415 354. 5 442 360. 8 472 000860 IK .fi.t-. .. y i >'8 0028 8. >*.-! FOGDJRR 138 02 2600398. 00 1R03674 028 027700435. 60 FOGDJRR 128 02780O359. 30 1R03675 028 027900454. 30 FOGDJRR 128 G28000214. 40 1F'03676 028 028100492. 50 F DJ RR 128 0282O0257. 10 1R02677 038 028300432. 40 FOGDJRR 128 028400353. 30 1R03678 028 028500447. 60 FOGDJRR 128 02860012-70. 70 1R03679 028 028700466. 40 FOGDJRR 128 *1128800351. 70 1R03680 028 02890*11452. 9G! FOGDJRR 128 029000350. 60 1RG3681 028 029100451. 50 FOGDJRR! 138 029200354. 40 1R036S2 038 *1129200375. 10 FOGDJRR 128 0294*30299. 90 1RG3683 028 029500470. 80 FOGDJRR 128 029600343. 10 1R02684 028 O29700451. 50 FOGDJRR 128 02980*3277. 90 1R3685 038 029900404. 00 FOGDJRR 128 02000*11371. 10 1RO t*y 6* 03'8 030100411. 50 F00DJ8R 128 030200384. 80 1R36S7 028 030300424. 10 FOODJAR 128 030400353. 90 1R3SSS 028 030500423. 60 FOODJhR 128 030600381. 10 _1 i^!t*6'9 028 03*3700256. 30 F . JDJRR 138 020800398. 90 1R03690 038 0201900448. 40 FOGDJRR: 128 031000351. 00 1R03691 038 FOGDJRR 138 02120 0374. 40 1RG3692 02S 031308340. 2Q FOGDJRR 13S 031400408. 30 1R03692 028 031500505. 80 FOGDJRR 128 031600346. 30 1R03694 02S 0131700455. 00 FOGDJRR 128 03180 0341. 20 1R03695 035 031900464. 20 FOGDJRR 135 03200*3362. 70 CiCiCiCiCiCiCiJtCiC 99 13 3 13 3 13 3 13 3 13 3 13 3 13 3' 13 12 2 12 2 12 2 12 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 0 388. 5 398 435. 6 359. 3 454. 3 314. 4 492. 5 357. 1 432. 4 353. 3 447. 6 370. 7 466. 4 351. 7 452. 9 350. 6 451. 5 354. 4 375. 1 299. 9 470. 8 ' 242. 1 451. 5 277. 9 404 371. 1 411. 5 384. 8 424. 1 253. 9 422. 6 281. 1 256. 3 298. 9 448. 4 251 337944..74 240. 2 408. 3 505. 8 246. 2 455 341. 2 464. 2 362. 7 BEST COPY AVAILABLE 473 000861 TWH VEAR ORAL-: DIET/ TOX-ONC STUDV OF FM-3924 & FC-143 IN RATS EXP. # 0281CR6012 TECHNICIAN INITIALS:S MH TOC-'AV S DATE :S 6/30/81 SEX OF R A T S :S HALE ROOM N U M B E R :S D-340, D-33S WEIGHT OF FULL FOOD JAP.:S 550GRAMS WEEK 10 1R83516 01S 007190507. 0Q FOODJAR 11S 007290357. 4Q 1R03517 01S 0O7390457. 80 FOODJAR IIS 007490370. 40 1R03518 01S 007590444. 70 FOODJAR 11S 007890386. 00 1R03519 01S 007790491. 90 FOODJAR IIS 007890269. 20 1R03520 01S 007990473. 40 FOODJAR 11S 010090387. 00 1R03521 01S 010190431. 30 FOOL'JAR IIS 010290371. 40 1R03522 01S 010390430. 20 FOODJAR IIS 010490398. 50 1R03523 01S 010590501. 60 FOODJAR 11S 010690336. 90 IP'^3524 01S 010790437. 00 F DJAR 11S 010890392. 90 1R03525 01S 010990448. 30 FOODJAR 11S 011090385. 40 1R83526 01S 0111901454. 80 FOODJAR 11S 011290379. 20 1R03527 01S 011390427. 80 FOODJAR 11S 011490394. 80 1R0352S 01S 0111590489. 50 FOODJAR 11S 011690364. 30 1R03529 01S 011790443. 50 FOODJAR IIS 0118901353. 70 1R02530 01S 011990473. 20 FOODJAR 11S 012090383. 50 1R03531 01S 012190450. 50 FOOC'JAR 11S 012290374. 30 1R03532 01S 012390444. 00 FOODJAR 11S 012490386. 60 1R03533 01S 012590491. 50 FOODJAR 11S 012690350. 50 1R03534 01S 012790517. 50 FOODJAR IIS 012890358. 60 1R03535 01S 012990398. 40 FOODJAR 11S 013090403. 3Q 1R03536 01S 013190416. 00 FOODJAR 11S 013290411. IQ 1 3537 01S 013390388. 00 FOODJAR IIS 013490398. 40 1R03538 01S 013590520. 40 FOODJAR 11S 013690365. 60 1R03539 01S 013790378. 70 FOODJAR 11S 013890410. 90 1R03540 01S 013990423. 90 FOODJAR 11S 014090398. 80 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1. 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 507 357. 4 457. 8 370. 4 444. 7 386 491. 9 369. 2 473. 4 387 431. 3 371. 4 430. 2 398. 5 501. 6 - 336. 9 437 392. 9 448. 3 385. 4 454. 8 379. 2 427. 8 394. 8 489. 5 364. 3 443. 5 353. 7 473. 2 383. 5 450. 5 374. 3 444 386. 491. 6cr; 350. 5 517. 5 358. 6 398. 4 403. 3 416 411. 1 388 398. 4 520. 4 365. 6 BEST COPY AVAILABLE 378. 7 410. 9 423. 9 398. 8 474 000862 * "n p x P "0 P T Wk T P T P T P T I fi o n T iai c* i_i ,X O XO i/J 0 Tf Or Is! C O o A X o X OX o 1 * f 1 XX o ut 0 w o w e p xi Tl O ?n Wc p -n P Ti r , T n M n 1.1 Tl H1 Tl p l""t Tl t ! Tl onr 10 Or-r 1,1 Tl H* -n K i i T? 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' 0 0 5 1 1' 5 0 f-OOL'JMR 11 020800.5 3 8. 60' 1Rti3575 0 1 3 0209010427. 10 f o o d j h f : 112- 0210002 50. t *0 1R03576 0l S 821100457. 00 FuuL'JHF I I S 0 2 1 2 0 0 2 9 1 00 JR0O577 013 021100488. 00 F" 'L'JHR 1 1 3 0 2 1 4 0 0 2 7 1 50 I, ..'3 5? 8 0 1 S 0^15010442. 80 F'JUD.'IHR 1 1 3 01*41600364. 40! 1R0O579 0'13 0217010450' 70! FOOL''JHF: 1 1 3 0218010381. 50 1R0358O 013 02190O442. 00 FOOL'JHR I I S 0 2 2 0 0 0 2 7 9 . 70 1R03581 0 2 S 01221004501. 80! FOOL'JHR 1 2 3 0 2 2 2 0 0 3 7 2 . 90! 1R03582 0 2 S 0.1223002 31. 20! FOOL1JHR 1 2 3 0 2 2 4 0 0 4 0 3 . 70! 1R02583 0 2 S O' 2 2 5 O'O'3 012. 3Q FOOL JHF: 1 2 Oi226iGi406. 40 1R02584 023 022700383. 20 FOOD JHF: 1 2 S O228O10378. 90! 1R03585 0 2 S 0 2 2 9 0 0 3 9 0 . 10! FOOL'JHF: 123. 0220001372. 70 1R03586 0 2 3 0 2 3 1 0 0 4 1 2 . 50! FOOL'JHF: 2 3 0232001377. 90! 1R03 587 0 2 S 0 2 2 3 0 3 4 9 . 10! FOOL'JHR 1 2 3 0 2 3 4 0 0 4 0 6 . 50! 1R03588 0 2 S 0123500297. 80! FOOL'JHF: 1 2 3 0 2 3 6 0 0 3 8 5 . 40! 1R03589 0 2 S 0 2 3 7 0 0 3 8 0 . 10! FOOL JHF: 1 2 3 0 2 3 8 0 0 3 6 0 . 70 IP O'3590 0 2 S 0123900478. 50 F D JHF: 1 2 3 '240100359. 10 1R03591 023 024100318. 00 FOOLJHR 123' 0 2 4 2 0 0 3 8 7 . 60! IF:03-592 0 2 3 G' 2 4 3 0 0 4 5 0 . 60! FOOLJHR 1 2 3 2 4 40 0 3 67 . 40! 1R03593 0 2 S 0 2 4 5 0 8 4 0 6 . 70` FOOL'JHR 1 2 3 01246010347. 20! 1R03594 0 2 3 0 2 4 7 0 0 4 3 7 . 20! FOOL'JHF: 1 2 3 02480036*4. 90! 1R03595 0 2 S 01249010358. 70! FOOL'JHF: 1 2 3 0 2 5 0 0 0 3 9 7 . 90 1R03598 0123 02510.10443. 90! FOOL'JHR 1 2 3 0 2 5 2 0 0 3 7 3 . 90 1R02597 0 2 3 Gi253Gi0372. 90! FOODJHR 123 02540391. 00 1R03598 0 2 3 0 2 5 5 0 0 4 3 8 . 30! FOOL1JHR 1 2 3 1256010374. 80! 1R03599 023 0257004010. 30 FOODJHR 123 025800374. 30 1R03S00 023 025900374. 30 FOOL'JHR 1 2 3 0 2 6 0 0 0 3 8 5 . 20 1R03S01 023 026100423. 60 FOOL'JHR 1 2 3 0 2 6 2 0 0 3 7 1 . 50 IF:03 602 23. 01263010386. 10 FOOL'JHF: 1 2 3 8 2 6 4 0 8 3 8 8 . 70 I' '3603 O'2b 02 65001412. 20 R.. ..L'JHR 12b 2 6002 7*: 60 1R03604 023- 02 6703 S '. 80 FOOL'JHF: 12b 02 68GiO'42. 80 J.R03605 02b 02 03*002tf4. 10 FOOL'JHR 123* 02 70O03:73*. 60 1R03806 2S 02 71803:72. SO FOOL'JHR 12b 02 7200412. 30 1 11 1 11 1 11 1 11 1 11 1 11 1 11 2 2 2 12 12 2 12 2 12 2 12 2 12 2 12 2* 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 51. 5 338. 6 427. 1 350 6 457 391 488 371. 5 442. 6 364. 4 450. 7 781 5 442 379. 7 450. 8 372. 9 331. 2 403. 7 3 O'2. 3 406. 4 383. 2 378. 9 390. 1 372. 7 412. 5 377. 9 349. 1 406. 5 397. 8 285. 4 380. 1 360. 7 478. 5 259. 1 318 387. 6 4501. 6 367. 4 40'6. 7 247. 2 437. 2 364. 9 358. 7 297. 9 443. 9 373. 9 372. 9 291 438. 2 374. 8 400. 3 374. 3 374. 2 285. 2 423. 6 371. 5 386. 1 388. 7 412 373 337 e* 8 BEST COPY AVAILABLE 413 8 384 1 379 6 372 8 412 482 000870 l R t l j . 6 0 / t .i _ . 02.-2 0 0 4 1 4 , 60 FOOL'JRF: 1 2 02 4 0 I_1_ , 6 10 jR ti2 6 y 022 0127600401. 10 FOODJRR 12S 027600341. 20 IF:O l t 09 023 02 77ti378. 60 FOt'..IRR 1 2 S 02 7 6 00373. 60 1 R O 2 6 10 0 2 6 102740101465. 20 F ..'JRF: 1 2 S- 0 2 6 0 0 U 2 6 4 . 90 1R01611 02S 026100377. 80 FOOD JRF: l w _ - l '2 ; :2 0 O 80. 80 -t'JLc: 0>2-- 0 2 63-00402.' 60 F OOD JRF: 1 2 6 0126401013 63.. 10 1R2 613 0 2 02650106010. 50 FOOL' JRR 126 026:600354. 00 1R03614 02S 028700411. 20 F OD'JRR 126 0 2 8 8 0 0 2 3 0 . 10 1 R 0 3 6 1 5 0123 0 2 8 9 0 0 2 7 2 . 70 FOODJRR 126 029000270. 60 1RO3616 02S 029100408. 50 FOODJRR 126 029280271. 60 1R03-617 026 0 2 92 0 0 38 6 . 70 FOOD JFlF* 1 2 6 0 2 9 4 0 0 2 8 7 . 20 1 R 0 3 6 1 8 0 2 S 012950101449. 60 F UUD J RR 126 0 2 9 6 0 0 2 6 5 . 80 1 R 0 2 6 1 9 0 2 0 2 9 7 0 0 3 5 1 . Gl FOOD J FlR 126 0 2 9 8 0 0 2 8 5 . 60 1R03620 02 2 00387. 5G F UD JA R 1 2 6 03 010010269. 50 1R03-621 0 2 S 020100228. 50 F DJRR 12S 1020200414. 00 1R03622 02S 020200224. 20 FOODJRR 126 020400298. 70 "3 6 2 3 0 2 6 0 2 0 5 0 0 2 6 6 . 90 F - j D JR R 1 2 S 0 2 0 6 0 0 2 8 5 . 20 1 R 0 2 6 2 4 2 0 3 0 7 0 0 4 1 8 . OG F ODJAF' 126 020800262. 50 1 R 0 3 6 2 5 0 3 0 0 S 0 0 3 2 S*. 3-G! F OODJRF: 126 0 2 1 0 0 0 2 8 5 . 30 1R03626 02S 021100418. 20 FOODJRR 126 021200278. 10 1F'0 3 6 2 7 021 0212 0 03 89. 6 G! FuOD JRR 126 021400292. 20 1R 0362S 026 02150 0 39 1. 9Q FOODJRR 126 021600297. 20 1R03629 02S 031700430. 90 FUDJRR 126 021800370. 10 1R03630 026 021900232. 40 FUD JFtR 1 2 6 0 2 2 0 0 0 4 0 2 . 40 1R02631 026 022100454. 30 FOODJRR 126 O22200375. 70 1R3632 02S 022300413. 80 FOODJRR 12S 022400363. 70 1R03633 02S 32500449. 60 FOODJRR 12S 022600272. 70 1R03624 02S 032700295. 70 FOODJRR 126 022800295. 50 1R03625 026 022900225. 00 FOOD1JR R 1 2 6 0 3 3 O 0 0 4 0 4 . 20 3 3636 026 033100435. 00 FOODJRR 128 022200281. 10 1R03637 03 03 3308383. 6Q FOODJRR 126 22400375. 70 1R03638 26 032500267. 20 FOODJRR 12S 0226003/ . 0 1R03639 02S 022700292. 90 FOODJRR 12S 033800281. 90 2 12 2 1.2 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 &"* 12 2 12 2 12 2" 12 "i 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 414 279. 1 451. 1 241. 2 378 8 373. 6 465. 2 264. 9 3-7 7. 8 280. 8 402. 5 283. 1 500. 5 354 411. 2 330. 1 372. 7 370. 6 408. 5 271. 6 286. 7 287. 3 449. 6 365. 8 351 385. 6 387. 5 369. 5 338. 5 414 334. 2 298. 7 386. 9 385. 2 418 262. 5 329. 3 385. 2 ` 418. 3 378. 1 389. 6 392. 2 391. 9 297. 2 430. 9 370. 1 332. 4 402. 4 454. 3 375. 7 412. 8 362. 7 449. 6 372. 7 295. 7 295. 5 325 404. 2 435 381. 1 383. 6 375. 7 367. 2 378. 9 293. 9 381. 9 BEST COPY AVAU ABLE BEST COPY AVAILABLE 483 C00S71 Ik u _>r'-4y '.1,44. 0 _ 8 0 0 481. 40 f-uut'JMF: I2 z. '.'4000411. 30 JR82641 0 2 S 0^4100426. 20 FOOL*JRF: 128 024200282. 70 1F03642 026 O 2 42 0 0 2 2 7. 00 FOOL' Jh F' 1 2 2 024400427. 20 1R02641 628 4 4500412. 90 F ' '`C'.TFtR 1 2 z. 0 2 46004.8 2 .2 0 1. .'2644 0 2 2 04-4700272. 80! FOOL' JRF' 128 >j2 480ti2.62 80! IRoo 645 0 2 8 0^.4900464. -20! FOOL' JRF: 128 02 5000342. 90-! 1F0'2646 02 8 02 5100278. 40! F L'OL'JRR 128 'Ii252t'0401. 90 1F02647 02 035200470. 40 FOOL'JRF: 1 2 8 035400379. 50 1R0364S 02 8 03 5500527. 00 FOOL'JRF 1 2 8 025600352. 70i 1R03649 02 35700470. 80 FOOL'JRF 138 0358001232. 20! IF:012650 0 2 S 035900410. 30 FOOL1JRR 1 2 S 02600421401. 5Q 1R02651 0 2 036100464. 10 FOOL'JRF: 1 2 036200372:. 00'! 1R02652 02 01363010446. 40! FOOL'JRR 128 O14 640013 82. 5G 1R02652 02 03650101447. 10 F OOL'JRF: 128 02660O'2 71. 80! 1F02654 028 036700495. 10 FOOL'JRF: 126 036800366. 20 1F03655 028 036900481. 70! FOOL'JRF: 126 037000354. 90 1F02656 0138 037100489. 90 F L'JRR 128 837200366. 40 1F02657 028 01272001470. 10 FOOL'JRF: 128 037400369. 10! 1R82658 02:2. 027500440. 70 FOOL'JRR 12 8 37600402. 20! 1F02659 02: 037700441. 90 FOOL'JRF: 128 037600272. 70 1F:0 668 02 027900480. 20! FOUL1JRR 128 038000380. 20 1R02661 028 0281001459. 70 FOOL'JRF: 138 0128200369. 70 1R02662 028 038300359. 80! FOOL'JRF: 128 028400418. 00 1R03662 038 038500515. 50 FOOL'JflR 138 038600366. 40 1F03664 0JO 038700419. 90 FOOL'JRF: 128 038800299. 20 IF:02665 038900443. 70 FOOL'JRF 138 029000387. 10 1F:03666 038 029100446. 00 FOOL'JRF 138 029200371. 80 1R03667 028 039300330. 10 FOOL'JRF 138 029400413. 20 1F02668 0138 0395010351. 70! FOOL'JRF: 138 039600413. 70 lr ''3:669 028 039700468. 10 F _ ..L'JRF 128 029800367. 50 1R0J670 028: 029900475. 10 FOOL'JRF 138 01400010259. 90 1F:03 671 038 0401010422. 80 FOOL'JRF: 128 040288364. 20! 1R03672 026' 0i4Oi30Oi462. 80 FOOL'JRF: 138 0404010283. 30 11* 1 12 2 12 si 12 cL 12 2 12 s 12 *' 12 13 2 13 3 13 7; 13 13 2 13 3 13 2 13 3 12 3 12 j. 12 *<; 12 2 12 3 12 2 12 2 12 3 13 3 13 3 13 12 3 12 3 13 3 13 2 12 3 13 481. 4 411. 3 426. 2' 282 7 427. 2 412. 9 282. 2 272. 8 362. 8 464. 2 242. 9 278 4 401. 9 470. 4 379. 5 527 252. 7 470. 8 332. 2 410. 3 401. 5 464. 1 27*2 446. 4 382. 5 447. 1 371. 8 495. 1 366. 2 481. 7 354. 9 489. 9 266. 4 470. 1 369. 1 440. 7 40. 2 441. 9 272. 7 480. 2 380. 2 459. 7 369. 7 359. 8 418 515. 5 366. 4 419. 9 399. 2 443. 7 387. 1 446 271. 8 330. 1 413. 2 251. 7 412. 7 468. 1 367. 5 475. 1 359. 9 432. 8 364. 2 462 382. 3 BEST COPY AVAIIABLE 484 CC0S72 KtfJ-C-i'j: oj:i- o4 0 0 oo4iu. yo FOOD Jh F: O S t'4o6t'0386. 60 1R02674 O38 0*4o 7uo467. 20 f-OOL1JRR 123' 040800278. 20 1R02675 28 040900489. 20 FODD JHR 1 2 8 04100Oi362. 1 0 l,ri3676 02 8 041100518. 6 Q F D-JftR 128 041200268. 70 1R0367? 03 3 841380461. 2Q FOODJRR 1 2 8 041400362. 90 1R03678 028 0415010471. 60 FuODJHR 12S 041600378. 6 Q 1R63679 28 041700500. 60 FOOD-JHR 12S 041800257. 50 1R0368 02S 041900484. 20 FOODJh R 138 042000353. 70 1R02681 02:8 042100482. 10 FOOD JHR 128 042208362. 10 IF'02682 022' 042200289. 20 FOODJh R 128 0424O0410. 00 1Ri2682 028 0425610498. 50 FOODJRF: 13S 0426m 0256.SO. 1R02884 028 042700487. 60 FOODJRF: 138 042800248. 30 1R02685 028 042900424. 10 FOODJRF: 128 42000279. 3Q IF:02888 02S 843100441. 80 FOOD JHR 128 04210612:82. 1 0 1R02 887 023 043300461. 50 FOODJRF: 128 6'42400267. 70 . 1R03688 038 043500458. 00 FOODJRR 133 6i4366'0262. 30 3 '2688 03S 043700377. 10 F jD JRR 12:8 0438610297. 50 1R02698 038 043900470. 90 FODDJHR 128 044000367. 60 1R03681 028 044100412. 50 FOODJRF: 138 044200376. 80 1R03692 02 8 044100357. 50 FOOD JRF: 128 044400411. 80 1R03692 038 44500546. 70 FOODJRR 128 44600344. 50 1R03694 028 44700497. 60 FOODJRR O S 044800346. 70 1R03695 028 044900492. 70 FOODJRF: 138 045800262. 70 QC| 12 12 13 2 13 13 4 12 2 1*>2 13 13 j. 13 3 12 3 13 12 3 13 13 13 3 13 3 13 2 13 3 13 3 13 2 12 3 13 0 BEST COPy AWill ABLE 410. y 386. 6 467. 2 --T'W. 489. 3 362. 1 518. 6 268. 7 461. 2 363. 9 471. 6 378. 6 500. 6 257. 5 484. 2 353. 7 482. 1 362. 1 289. 2 410 498. 5 356. 6 487. 6 348. 2 424. 1 379. 2 441. 8 382. 1 461. 5 ' 267. 7 458 362. 3 377. 1 397. 5 470. 9 367. 6 413. 5 376. 8 357. 5 411. 8 546. 7 344. 5 497. 6 346. 7 493. 7 362. 7 485 000873 KsicoprAmm 1WO VEAF' u KAL'-.DIEI TOX- O N C S T U D Y OF FM-2 9 2 4 * F C - 1 4 2 IN RATS EXP. # 0 2 8 1 C R 0 U 1 2 1E C H N I C IAN INITIALS:S MH TODAY S D A T E :S 7/14/81 EX OF RATS.S MALE - R O O M N U M B E R :S D- 240, D-328 HEIGHT OF FULL FOOD J A R :S 550GRAMS WEEK 12 lR82S.lt. 01 0 3108508. 8Q FOOD J R R U S 0 8 ?200i381. 20 1R02517 81S 00?20462. 90 FOODJRR IIS 0i07408376. 30 1R02518 01 00 7508465. 40 FOODJAR IIS 0017600404. 00 1 R 8 3 5 1 9 01S 00?700i514. 80 FOODJAR IIS 00?80266. 20 1R:02520 0113 08 7900488. 40 FOOD J R R U S 0i101010101375. 80 1R02 5 2 1 IS 0il0ilt'0450. 70 FOODTAR U S 0102O0373. 20 1R03 5 2 2 01S 01013010450. 90 FOODJAR IIS 010400393. 10 1R02522 IS 010500520. 10 F OODJAR IIS 0101600377. 80 1RA3524 01S 018788456. 80 F DJAF: IIS 01108001386. 00 1R02525 01S 010980461. 80 FOODJAR: IIS 01100101387. 00 1R63526 01S 011100476. 20 FOODJRR IIS 011200382. 50 1R02527 81 S 01.11300459. 10 FOOD J A R U S 0114001409. 40 1R03528 81S 011500503. 30 F OODJAR U S 01160101368. 80 1R82 5 2 9 01S 0117001467. 80 FOODJAR IIS 811888381. 60 1R83530 01S 011900492. 60 FOOD J A R IIS 011200036:7. 50 1R83531 01S 012100471. 60 FOODJAR IIS 012200283. 10 1R83522 01S 012360472. 30 FOODJAR IIS 812400397. 80 1R03533 01S 012500508. 20 FOODJAR 113 012600369. 70 1R83534 013 012700540. 70 FOODJAR 113 012800371. 70 1R83535 013 012908406. 20 FOOD J A R 113 0120010407. 30 1R82536 813 012180438. 80 FOODJRR 113 013200398. 40 J. 3537 013 0122-00404. 70 FoUDJAR 113 012400415. 50 1 R 8 3 S 3 8 0 1 S 01.2*500546. SO FOOD J A R lls Ul.ic-0y.s54. 0 1R03529 013 013708390. 20 FOODJAR 113 013888480. 80 1R03548 013 013980444. 70 FOODJAR 113 014000418. 00 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 '1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 508. 8 381. 2 462. 9 376. 3 465. 4 404 514. 8 366. 2 488. 4 375. 8 450. 7 3 7"^- 2 450. 9 392. 1 520. 1 377. 8 456. 8 386 461. 8 387 476. 2 382. 5 . 459. 1 409. 4 503. 3 368. 8 467 381. 6 492. 6 287. 5 471. 6 383. 1 472. 3 397. 8 508. 2 269. 7 540. 7 371. 7 486. 2 487. 3 438. 8 298. 4 404. 7 415. 5 546. 6 354. 3 290. 3 408. 8 444. 7 418 486 000874 lROu.541 0X8- 014100001 70 FOOD JRR 111 Ol4100202. 0 lR0i542 Oil 014200484. 60 FOODJRR 111. U14400408. 40 1R02542 011 014500528. 00 FUUL1JRF 111. `2146013336. 20 1R03544 `31i 0147 "3482. 50 F DJRR 111 `3140002 64. 20 IFU2545 Oil 014800518. 8`3 F`JC`DJRR H i 015*000264 20 1 R 0 2 5 4 * O H 015100520'.' 00 FC`C`DJRR 111 015*200281. 40! 1R02547 `311 `3152`3`3522. `0! FOC`D JRR 118 015400356. 50 1R03548 Oil 015500535. 5 FDOC'JRR 112 015600285. 50. 1R03549 011 015700445. 70! FODD JRR 118 015*800381. 20 1R03550 018 .15800458. 30! FODDJ RR 118 016000287. 50 1R03551 l Q FOODJRR 118 016200416. 60 1R02552 `318 016200510. 80! FOODJRR 118 `3164*30267. 50! 1R01552 Oil Olc.5oo551. 30 FOODJRR U S 016600352. 80! 1ROC 554 *312 `3167330289. 7Q FOODJRR 118 016800286. 80! 1R02555 `318 016800458. 10! FOOL*JRR 118 017000384. 80 1R02556 018 017100518. 40 FOODJRR 112 017200281. 40 lr"',3557 018 017200457. 2Q F DJRR 118 0174010280. 10! 1R0255S `318 `317500386. 00! FOODJRR 118 017600284. 70 1R03559 018 0177O0488. 70 FOODJRR 112 `3178010408. 20! 1R03560 `318 17800438. 50! FOODJRR 118 `3180001286. 50 1R03561 012 013100527. 00 FOODJRR 118 `3182010346. 80 1R03562 018 118200349. 60 FOODJRR 118 018400421. 00 1R02563 018 018500432. 10 FOOt.1JRR 118 018600284. 80 1R02564 OHS OU8700455. 30 FOODJRR 118 018800409. 50 1R02565 018 018800484. 20 FOODJRR 118 018000387. 00 . 1R02566 01S 018100435. 30 FOODJRR IIS 018200372. 20 1R03567 IS 018200514. 80 FOODJRR 118 018400388. 60 1R03568 018 018500514. SO FODD JRR: 118 018600265. 80 IRO'2569 018 `319700504. 70 FOODJRR 118 018800342. 80! 1 570 018 0188001482. 10 Foot *JRR 118 020000264. 50 1R02571 012 020100517. 40 FOODJRR 118 020200262. 00 1R02572 012 020300482. 80 FODJRR 118 820400355. 00! 1P02573 018 0120500501. 00! FOODJRR 118 020600370. 10 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1- 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 BEST COPY AVAIlABLE 501. , 282. 2 464. 6 408. 4 236. 2 482 5 264. 3518. 8 264. 2` 520 281. 4 522. 8 256. 5 535. 5 285. 5 445. 7 381. 2 458. 2 387. 5 354.1 416. 6 510. 8 267. 5 551. 2 253. 8 388. 7 386. 8 458. 1 384. 8 518. 4 381. 4 457. 2 380. 1 386 284. 7 488. 7 408. 2 428. 5 386. 5 e r-7.-"7 346. 8 354.2 421 432. 1 284. 8 455. 3 408. 5 484. 3 397 435 3 373.2 514. 8 288. 6 514. 8 265. 8 504. 7 242. 8 482. 1 264. 5 517. 4 262 482. 8 355 501 370. 1 487 000875 J Ki.' _ ` OIL:. 0^.0. 0 0 5 1 0 40 H j i j L-' (HP: U L -. 0i3O80' tl4 9c., t'0 IROU 5 7 5 011'.-.. 0 2 0 9 0 0 4 3 1 . 20 PC'OL' J h R 11 -, 02100102 55. 4 0 1 R 0 2 5 7 6 113 '211010462. 5 0 P Out J HP 113. 0 2 1 2 0 0 5 91. 2 0 1R>.C , 7 0i12. 0 2 1 3 U 0i4 9 2 . 4t! P HP' I I S 1214001377. 10 J tv..2 5 7 8 0i12. 0i2150i0 4 4 6 70 FOOL* JHP: 11 - 1216002501. 90 1R02579 U S 0i21.0 0 4 6 4 7 60 FOOL'.i HP: 11;. 0121800547'. 40 1 R 0 3 5 8 0 113 12190101445. 30 FOUL'JHP: 113 0228010288. 80 1 R 0 2 5 8 1 0i23: 00 0 8 8 0 8 8 . OC! F ODD J HP: 1 2 S 0 0 ` 0 0 0 2 7 1 . 20 1 R 0 3 5 8 2 0 2 8 10' 71003 2 5. 10 F O O D JH R 1 2 S 0i 0i ?20i0i2 9 6 . I Q 1 R 0 2 5 8 2 128 ''73 0101217. 50 FO O L'J HP: 1 2 8 101` '40101299. 20 1 R 0 2 5 8 4 0123 00?5 03-96. 0G F OO L'J HP: 1 2 8 0101760103:75. 20 1 R 0 2 5 8 5 0 2 S 'O'7701014015. 90 F OOC1J HP: 12'-. 0101"'800286. 80 1P:0i2 5 8 6 0128 010179001422. 3G FOOL1J HR 1 2 8 0110010101376. 50 1 P'035 87 0 2 8 011011.00255. 80 F OOD JHP: 1 2 8 0il0i20i0i249. 80 IP '0 2 5 8 8 0 2 8 01012010394. 10 FOOL'JHP: 1 2 S O 1O 400295. 50 IP '05 5 8 9 0 2 8 0110150101284. 70 FO O D JH R 1 2 8 01101601013:87. 70 1 3 5 9 0 0 2 8 010170101492. 4Q F OOL1j h p : 1 2 8 O1OS0615-67. 40 1 R 0 2 5 9 1 0128 0ilo90i0i222. 2 0 FOOL* JHP: 123'. 01110101014019. 30 1 R 0 2 5 9 2 0i28 011110101461. 3 0 FOOD JHP: 128 0 1 12 0 0 27 0 . 60 1R03593 028 0113001412. 00 FO O L'J HP: 1 2 8 0 1 1 4 0 0 2 8 7 . 0 0 1R02594 028 O11500448. 80 FOODJHR 128 0116010262. 00 1R02595 028 011700359. 40 POOL'JHP: 128 0 1 1 8 0 0 4 1 5 . 30 1 R 0 2 5 9 6 0 2 8 1119001455. 10 FOOD J HR 1 2 S 0112000375. 10 IP:02:597 0 2 8 0 1 2 1 0 0 3 8 1 . 40 FOODJHR 12S 0112200293. 30 1R0259S 02S 012200444. 20. FOODJHR 12S 012400281. 30 1R03599 02S O12500409. 80 FOODJHR 12S 01260280. 20 1R 0J600 02S 012700283. 30 FOOL'JHR 1 2 S 0128010389. 40 1 R 02 6 0 1 0 2 S 1129010424. 70 FOOL1JH R 1 2 8 11300101276. 1 0 1R03602 028 012100294. 10 F DJHR 128 013200380. 00 lh 0 3 6 0 3 0i2S 0 1 3 3 0 0 4 1 6 . 20 F OOL'.'HR 12 8 0 1 3 4 0 0 2 8 5 . 80 1 R 0 5 6 0 4 0 2 8 113.5010357. 5 0 FOOL'JHR 128 112600432. 20 IP :036'0i5 0>2'3. 1 3 7 0 0 3 8 9 . 50 FOODJHR 12S 13800374. 60 I P 02606 0 2 S 0139010382. 20 1 11 1 11 1 11 1 11 1 11 1 11 1 11 e- 12 d 12 2 12 2 12 2 12 2 12 **i - 12 2 12 2 12 12 2 12 2' 12 2 12 2 12 2 12 2 12 2 12 - 12 2 12 ici 12 cl 12 d 12 -> 12 2 12 2 510. 4 396 6 431 2 355. 4 462. 5 391. 2 492. 4 377. 1 446. 7 350. 9 464. 6 347. 4 445. 3 388 8 4 6 1 .2 371. 2 335. 1 396. 1 317. 5 399. 2 296 275. 2 405. 9 386. 8 422. 2 276. 5 255. 8 249. 8 394. 1 395. 5 384. 7 387. 7 492. 4 367. 4 322. 3 489. 3 461. 2 378. 6 413 387 448. 8 362 359. 4 415. 2 455. 1 275. 1 281. 4 3:93:. 3 444. 2 281. 3 409. 8 388. 3 282. 3 289. 4 424. 7 276. 1 394. 1 380 416. 2 285 357. 5 422. 2 389. 5 274. 6 382. 3 BEST COPY AVAUABIE 488 G00876 FyuDJhF j.j y Jm yu yJijL-i 2 u lk6i2607 122 0141O041 &. 20 FuuD JHF: 12 014200380. 80 1R03608 028 0143-00460. 10 FOODJAR 128 011440013 3 7. 30 1R03609 0>2 011400013 89. 60 FOODJflk 12S 0114601013-72. 0O 1 610 0122 011470101473. 20! FuuD JMR 123 014800297. 60 lRy2611 0145^^0284. 1C.' FyODJHF: 123- y i00101014016: 40! 1R02612 023 010100417. 20 FOOL1JFtF: 123 0152010138 7. 90 1R6'3612 0123' 015300496. 20 FOODJflR 128 0115401013.78. 20 1R03614 0'2S 01155010413. 40! FOOD JflF: 128 015600277. 40 1R03615 0128 015700364. IQ FOODJflR 128 01158010292. 80! 1R03616 0'28 011590104019. 50 FOODJflR 128 016000382. 50 1R03617 0'28' 611616101288. 86! FOOD JflF: 128 0162004101. 60 1R03618 6128 016308454. 30 FOOD JflF: 128 0164001274. 50 1R03619 028 0165061355. 30 FOOC:'JflF: 128 01660101392. 10 1R03620 0i28' 0116761012901. 00 FOOC'JflR 128 816800379. 10 1R83621 028 01696i6i244. 50 FOODJflR 128 01170010419. 86! 1R03622 028 017100339. 10 FF-'DJflR 128 017200399. 10 1. 3623 028 017200364. 00 FOOD JflF: 128 017400422. 80 1R03624 02S 017500419. 10 F'OODJflF: 128 0176001368. 70 lF:y:625 028 017700329. 20 FOOD JflF: 128: 611780101398. 00 IF'013626 028 0117900432. 20 FOOD JflF: 128 0180002-79. 46! 1R03627 0i28 0181001394. 20 FOODJflR 128 018200395. 80 1R0362S 028 01182.001398. 76! FOODJflR 128 018400402. 20 1R03629 028 018500441. 40 FOOD1JflR 128 018600371. 90 1R03630 028 0187010339. 70 FOODJflR 128 018800406. 20 1R03631 02S FOODJflR 128 019000383. 70 1R03632 028 019100414. 70 FOODJflR 128 0192 0375. 40 1R03633 028 019300453. 60 FOODJflR 128 019400370. 60 1R03634 028 019500294. 60 FOODJflR 128 019600423. 70 1R03635 028 019700331. 30 F DJfiR 128 019800410. 30 Iky3636 028 019900432. 86! FOODJflR 128 61200003:89. 46! 1R03637 0128 02016161385. 80 FGOD'JflR 128 0126120102-78. 80 1R03638 028 02030O370. 30 FOODJflR 128 01204001390. 90 1R03639 028 0201500387. 90 12 k 12 12 2 12 2 12 12 2 12 C12 2 12 12 2 12 2 12 2 12 2 12 2 12 2 12 Cl 12 2 12 2; 12 2 12 2 12 2 12 2 12 s! 12 2 12 2 12 2 12 cL 12 2 12 2 12 2 12 2 12 2 12 2 418. 2 385. 8 466. 1 |, ji. 28S*. -- !-- 473. 2 397. 6 384. 1 406. 4 417. 2 387. 9 496. 2 378. 2 413. 4 377. 4 364. 1 392. 8 409. 5 382. 5 388. 8 410. 6 454. 3 374. 5 355. 3 392. 1 390 37S. 344. 5 419. 8 339. 1 399. 1 364 422. 8 419. 1 368. 7 329. 2 398 432. 2 379. 4 394. 2 395. 8 398. 7 402. 2 441. 4 371. 9 "?Q 7* 406. 2 460.2 &S. 7 414. 7 375. 4 453. 6 370. 6 294. 6 423. 7 331. 3 410. 3 432. 8 389. 385. 378. 4 8 8 BEST COPY AVAILABLE 370. 3 390. 9 387. 9 489 000877 FUUl'JHK I---- L4Ol _10J UiJ 1F'JZ64 *j 0 4 - 040700 2 00 70 FOur'.1HR' 126 020800420 10 IF >-'-641 ij2S 02O40041H. yi.. FOOL'JMF' 126 021002-62. 00 lh;03 642 044 021100334. 2'G` FOOL'JMF: 126 021200418 20 1 7642 2212 00414. 50 Fu u L'Jm F: 126 021400381. 00 i KOI 644 0515 U02 78. 26 FOOL'Jm F' 126 0 2 1C .0 0 2 7 2 5G-! 1F02645 u2b 021700468. 60 FOOL'Jm F: 2S 0218010271. 50 1F:02646 02 4 O219O0392. 00 FOOL'JMR 126 022000247. 2Q 1R03647 02 S 022100482. 00 FOOL'JFlF: 12 6 0222002.75. 20 1R03648 02 4 02230525. 80 FOOL'JMF: 126 022400257. 60 1F:Z*2649 026 022500471. 90 FOODJftF: 126 022600364. 00 1R 0 3 6 5 0 02 S 022700413. 00 FODDJMR 126 022800248. OQ 1R02651 02 4 022900462. 90 FOOL'JMF: 126 0123000277. 50 1R02652 02 4 023100459. 20 FOOL'JMF 126 02220022-0. 80 1R02652 02 S 22300455. 90 FOOD JAR 126 023400377. 50 1R02654 02S 1122500503 .40 FODDJAR 125 Zi226Z'8292. 20 IF: 0 16 5 5 02S 023700472. 30 FOOL'JMR 12 5 0238ZiZ*394. 50 i. 2656 02S 022900488. 60 FOOD JMF: 135 024080375. 70 1R83657 024 024100469. 80 FOOL'JMF: 126 024200379. 60 1R 1*2658 02S 024300436. 3Q F OODJhR 125 024400412. 50 1R02659 024 024500452. 20 RUODJh R 12 6 024600375. 10 1R02660 02 2* 024700479. 90 FOOL'JMF: 125 024800276. 5*0 1R02661 FOOL'JMR 125 O25000370. 60 1R02662 02 4 025100259. 20 FOOL'J MR 126 6252*30417. 90 1R03663 024 112520*3520. 10 F OOD Jm F; 125 325400264. 10 1R02664 02 S 025500417. 90 FOOL'JMR 135 325600404. 90 1R03665 025 025700446. 00 FOOL'JMR 125 025800414. 40 1R02666 025 025900452. 70 FOOL'JMR 125 026060375. 00 1R02667 024 026100338. 30 FOOL'JMR 125 3262*3*3434. 30 1R0266S 0 2S 32'6333359. 00 F 0 JMF: 125 32640*3430. 60 1KU3669 024 0265Z'Gi472. 20 FOOL'JMR 125 0 2 8 6 0 0 2 8 2 . OQ 1R02670 02S 326.700496. 2*2 FOOL'JMR 125 326.8Z10359. 20 1R02671 022'- 32>:.9ZlZi42*3. 10 FOOL'JMR 125 02700374. 60 1R02672 025 327100462. 50 12 2 12 C. 12 cZ 12 2 12 2' 12 2 12 2 13 13 13 2 13 3 13 3 13 3 13 3 13 3 13 jj. 13 13 -513 7 13 3 13 3 13 3 13 3 13 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 2O0 7 430. 1 419 9 262 334. 2 418. 3 414. 5 381 375* 2 373. 5 469. 6 371. 5 382' 397. 3 483 375. 2 535. 8 357. 6 471. 9 364 413 398 462. 9 377. 5 459. 2 330. 8 455. 9 377. 5 503. 4 393. 2 472. 3 394. 5 488. 6 375. 7 469. 8 379. 6 436. 3 .412. 5 452. 3 375. 1 479. 9 376. 5 466.5 370. 6 359. 2 417. 9 520. 1 364. 1 417. 9 404. 9 446 414. 4 452. 7 375 338. 2 434. 3 259 430. 6 472. 2 282 487.2 359. 2 BEST COPY AVAILABLE 433. 1 374. 6 462. 5 490 000878 FOODJHR l_i- D2r.20U_9b. 4U 13 _ 896. 4 6 j 08 02 72 004X4. SC! i- 414. 8 FOODJAR 138- 0274010411. 20 12 411. 2 JR03674 0i2-8 02750101475. 50 2 475. 5 FOODJAR 122 0127600279. 10 13 379. 1 IPO3675 0i2S 0127 7001494. 90 3 494. 9 FOODJAR 12S 027800285. 80 12 385. 8 1 3676 012 087900524. 50 3 524. 5 FOODJAR 122 028000269. 20 13 269. 2 1P02677 022 028100461. 10 3 461. 1 FOOD-JflR 12S 0282001400. 60 13 400. 6 1R03678 02S 028200469. 00 3 469 FOODJAR 12S 028400400. 30 12 400. 3 1R02679 02S 028500509. 90 2 509. 9 FOODJAR 12 028600288. 80 1R02-60 02S 028 70O487. 70 13 2 388. 8 487. "i7 FOODJAR 128 028800362. 00 1R026S1 O2 - O289O 48 7. 40 1"2 262 487. 4 FUL'Jh R 12 029000272. 20 13 373. 2 1R02 682 ti2 02910101394. 80 3 294. 8 FOODJAR 12 0292010411. 60 13 411. 6 1R03682 0i2 029200500. 80 S' 500. 8 FOODJAR 13 029400390. 30 13 290. 3 1R036S4 02 029500506. 80 3 506. 8 FUUC'Jh R 12 0296001348. 90. 13 248. 9 1R026S5 02 029700432. 20 2 422. 2 FOODJAR 12 0298010376. 30 12 276. 2 1R026S6 02S O299010454. 00 3 454 FOODJAR 12S 020000382. 70 13 282. 7 1R02687 012 030100465. 80 FOOD-JAR' 12 020200396. 70 3 13 *465. 396. 8"1J IR 0I2688 02 020300459. 20 2 459. 2 FF-'DJAR 12 030400370. 60 13 370. 6 1 , 2688 0i3 02O500278. 20 2 278. 2 FOODJAR 12 020600297. 80 12 397. 8 1R02690 0i2 020700472. 10 3 473. 1 FOODJAR 12 020300389. 50 13 389. 5 1R02691 03S 020900413. 40 3 413 4 FOODJAR 12 021000411. 40 12 411. 4 1R03692 02 021100361. 50 3 361. 5 FOODJAR 12S 021200428. 40 12 428. 4 1R02693 02 021300552. 60 2 553. 6 FOODJAR 13S 021400327. 50 13 337. 5 1R02694 02S 0215061499. 60 3 499. 6 FOODJAR 13S 031600360. 60 13 260. 6 1R02695 02 021700497. 60 3 497. 6 FOODJAR 12 021800386. 30 QCrQClQCtCi-<99 99 13 0 386. 3 BEST COPY AVAILABLE 491 G00879 TUO VEflR ORL<DIT> TOX-ONC STUDV OF FM-3924 & FC-143 IN RTS / EXP. # 0281CR0012 TECHNICIAN INITIALS :S-MH TODAY'S DATE :S 7/21/81 . SEX OF RfS:S MALE ROOM NUMBER :S D-240, D-338 WEIGHT OF FULL FOOD J A R :S 550GRAMS WEEK 13 1R03516 01S 007100523. 4Q FOODJFtR 11S 007200376. 4Q 1R03517 01S 007300477. 4Q FOODJFtR 11S 0O 7400357. 8G 1R03518 01S 007500464. 50 FOODJR U S 0076O0387. 30 1R03519 01S 007700524. 20 FOODJFiR U S 007800363. 10 1R03520 01S 00 7900499. 30 FOODJR lis 010000378. 90 1R03521 01S 010100458. 00 FOODJR lis 010200371. 10 1R03522 OIS 010300458. 8Q FOODJR lis 010400390. 80 1R03523 01S 010500534. 2Q F/' `D JR lis .. ..(2524 OIS 010700452. 10 FOODJR lis 010800379. 6Q 1R03525 01S 010900480. 30 FOODJR lis 011000379. 1Q 1R03526 OIS 011100489. 80 FOODJR lis 011200379. 10 1R03527 01S 011300464. 5Q FOODJR lis 011400387. 90 1R02528 01S 011500524. 7Q FOODJR lis 011600362. 00 1R03529 01S 011700485. 90 FOODJR lis 011800376. 60 1R03530 01S 011900507. 00 FOODJR lis 012800384. 5Q 1R03531 01S 012100493. 8Q FOODJR lis 012200340. 5Q 1R03532 01S 012300480. 6Q FOODJR lis 012400383. 40 1R03533 01S 012500528. 2Q FOODJR U S 012600364. 7Q 1R03534 01S 012700546. 9Q FOODJR U S 012800352. 4Q 1R03535 01S 012900428. 8Q FOODJR U S 013000398. 20 1R03536 01S '013100440. 6Q F >JflR lis 013200408. 0Q 1R03537 OIS 013300408. 4Q FOODJR U S 012400390. 6Q 1R03538 01S 13500561. 7Q FOODJR lis 013600237. 30 1R03539 01S 013700409. 0Q FOODJR lis 013800387. 30 1R03540 01S 013900450. 3Q 1 11 1 11 1 11 1 11 1 11 1 11 1 11" 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 523. 4 376. 4 477. 4 357. 8 464. 5 387. 3 524. 2 363. 1 489. 3 378. 9 458 371. 1 458. 8 390. 8 534. 2 377. 7 473.7 379. 6 480. 3 379. 1 489. 8 379. 1 464. 5 387. 9 524. 7 362 485. 9 376. 6 507 384. 5 493. 8 340. 5 480. 6 383. 4 528. 2 364. 7 546. 9 352. 4 428. 8 398. 2 440. 6 ih BEST co py available 561. 7 337. 3 409 387. 3 450. 3 492 G00880 FOODJftR U S 014000297. 60 1R03541 018 01410O515. 30 FOODJftR 11S 01420027fr. 20 1R02542 01S 0143004S0. 00 FOODJftR 11S 014400288. 00 1R03542 01S 014500556. 00 FOODJftR 11S 014600229 40 1' 3544 01S 014700507. 60 FL.uDJftR 11S 014800362. 20 1R03545 01 014900529. 60 FOODJftR 11S 015000361.' 60 1R02546 01S 015100529. 70 FOODJftR 11S 015200284. 90 1R02547 01S 015300541. 50 FOODJftR 11S 015400350. 90 1R02548 01S 015500535. 60 FOODJftR IIS 015600382. 80 1R03549 01S 015700448. 70 FOODJftR 11S 015800394. 6Q 1R02550 01S 015900468. 90 FOODJftR IIS 016000290. 00 1R03551 01S 016100360. 90 FOODJftR 11S 016200419. 50 1R03552 01 FOODJftR U S 016400261. 60 1R03552 01S 016500564. 90 FOODJftR 11S 016600355. 60 1R02554 01S 016700392. 70 FOODJftR 11S 016800405. 90 1R0355R 01S 016900467. 70 FOODJftR 11S 017000290. 40 1R02556 01S 017100538. 80 FOODJftR 11S 017200380. 90 3i 3557 01S 017200463. 90 FOODJftR 11S 017400291. 00 1R02558 01S 017500402. 20 FOODJftR U S 017600292. 90 1R02559 01S 817700493. 00 FOODJftR 11S 017800286. 90 1R03568 01S 017900442. 10 FOODJftR 1 1 s 018000292. 90 1R03561 01S 018100559. 70 FOODJftR 11S 018200342. 30 1R03562 01S 018200406. 80 FOODJftR 11S 018400237. 90 1R03563 01S 018500437. 40 FOODJftR 11S 018600396. 80 1R03564 01S 018700452. 80 FOODJftR 11S 018800289. 30 1R03565 01S 018900498. 50 FOODJftR 11S 019000275. 00 1R03566 015 019100438. 30 FOODJftR U S 019200388. 60 1R03567 01S 019300525. 3Q FOODJftR 115 019400275. 60 1R02568 01S 019500521. 40 FOODJftR 11S 019600377. 80 1R03569 01S 019700502. 20 F ``DJftR 115 019800375. 90 1.-^3570 015 019908462. 80 FOODJftR 115 020000428. 20 1R03571 01S 020100528. 80 FOODJftR 11S 020200270. 50 1R03572 01S 020300494. 10 FOODJftR U S 020400357. 60 1R02572 01S 020500511. 50 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 397. e 515. 3 276. 2 480 388 556 339. 4 507. 6 363. 2 529. 6 361. 6 529. 7 384. 9 541. 5 .350. 9 535. 6 383. 8 448. 7 394. 6 468. 9 390 360. 9 419. 5 499.1 361. 6 564. 9 255. 6 393. 7 405. 9 467. 7 390. 4 538. 8 380. 9 462. 9 391 402. 3 292. 9 492 286. 9 442. 1 392. 9 559. 7 342. 3 406. 8 337. 9 427. 4 296. 8 453. 8 389. 3 498. 5 375 438. 3 388. 6 525. 3 375. 6 521. 4 277. 8 502. 3 375. 9 462. 428. 8 2 BEST COPY AVAILABLE 528. 8 370. 5 494. 1 357. 6 511. 5 493 GQOSS1 FUODJHR 11S 0^06003/*; 50 1R03574 eas 020706528. 6Q FOpDJftR n s 020860382. 26! 1R03575 0 1 s 626906438 26* FOODJflR 11S 621000353. 90 1R03576 01S 621106270. 56* FOODJflR U S 021266471. 80 3 3577 01S 621388421. 66! FOODJAR 11S 621400455. 46* 1R03576 01 s 021506272. 06) FOODJflR U S 021600469. 40 1R03579 01S 021706414. 40 FOODJflR 11S 021806425. 70 1R03560 01S 621900392. 70 FOODJflR 11S 022600437. 2Q 1R03581 02S 00?100468. 80 FOODJflR 12S 067200372. 90 1R83582 02S 007360344. 70 FOODJflR 125 067400395. 2Q 1R03583 02S 007560333. 6Q FOODJflR 125 067600395. 60 1R63584 02S 007700468. 00 FOODJflR 12S 067800279. 00 1R03585 025 007906462. 20 FOODJflR 125 010000274. 40 1R83586 025 016100430. 50 FOODJflR 125 010200272. 70 1R03587 025 010360246. 50 FOODJflR 125 010400488. 6Q 1R03588 025 010500462. 10 FOODJflR 125 010600392. 90 1R03589 025 016700386. 30 F/' 'DJflR 125 010880368. 60 . j3590 025 016900501. 80 FOODJflR 12S 011060369. 20 1R83591 625 011160334. 90 FOODJflR 125 011200394. 60 1R62592 625 011306457. 90 FOODJflR 125 011400282. 90 1R03593 625 011500468. 70 FOODJflR 12S 011600466. 10 1R03594 025 011700462. 90 FOODJflR 125 011806364. 50 1R03595 62S 011900265. 60 FOODJflR 12S 012000394. 40 1R03596 625 012166465. 40 FOODJflR 12S 012260364. 3Q 1R02597 62S 012366388. 20 FOODJflR 125 012400396. 90 1R02598 025 012500447. 90 FOODJflR 12S 012600386. 80 1R03599 62S 012706420 00 FOODJflR 12S 012806372. 20 1R02600 02S 012906398. 80 FOODJflR 12S 013600386. 4Q 1R03601 02S 013106443. 10 FOODJflR 12S 012200356. 80 1R03602 62S 013300410. 20 F. >JAR 125 013400375. 00 1R03683 62S 013506425. 60 FOODJflR 12S 013600382. 10 1R03684 62S 013760352. 9Q FOODJflR 12S 013806418. 4Q 1R03605 62S 013980396. 00 FOODJflR 12S 014006386. 7Q 1R03606 02S 014160386. 20 11 1 11 1 11 1 11 1 11 1' 11 1 11 1 11 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 528. 382. 438. 353. 370 471. 421. 455. 372 469. 414. 435. 393. 437. 468. 373. 344. 395. 333. 395 408 379 402. 374. 436. 373. 346. 408. 403. 393. 386. 368. 501. 369. 334. 394. 457. . 382. 468. 406. 462. 364. 365. 394 465. 364. 368. 396. 447. 386. 428 372. 39e. 386. 443. 356. 410. 375 425. 383. 352. 418. 396 386. 386. BEST copy AVAILABLE 494 CQ08S2 FOODJAR 12S 014200409. 40 1F:03607 02S 014300420. IQ FOOD JAR 12S 014400274. 6Q 1R02688 02!s> 014500470. 9Q FOODJAR 12S 014600350. 0Q 1R82609 02 S 014700295. 8Q FOODJAR 12S 014300373. 5Q 1' 3610 02S 014900488. 90 Fi_..jDJAR 12S 015000266. 4Q 1F:02611 02S 015100387. 9Q FOODJAR 12S 015200231. 9Q 1R02612 02S 015300420. 2Q FOODJAR 12S 015400281. 8Q 1R03613 02S 015500503. 3Q FOODJAR 12S 015600371. 4Q 1R02614 02S 015700415. 9Q FOODJAR 12S 015800361. 4Q 1R02615 02S 015900369. 4Q FOODJAR 12S 016000359. 2Q 1R03616 02S 016100418. 9Q FOODJAR 12S 016200375. 4Q 1R02617 02S 016300399. 3Q FOODJAR 12S 016400286. 8Q 1R03618 82S 016500458. 7Q FOODJAR 12S 016600272. 4Q 1R83619 02S 016700364. 4Q FOODJAR 12S 016800236. 6Q 1R03620 02S 16900413. 2Q FOODJAR 12S 017000259. 8Q 1R02621 02S 017100351. 6Q FOODJAR 12S 017200412. 2Q 1R02622 025 017300351. 4Q FOODJAR 125 017400289. 30 1 3622 02S 017500365. 4Q FOODJAR 125 017600402. 4G 1R03624 025 017700427. 30 FOODJAR! 125 017800271. 2Q 1R03625 025 017900230. 2Q FOODJAR 125 018000295. 0Q 1R02626 025 018100430. 7Q FOODJAR 125 013200212. 9Q 1R03627 025 018300409. 2Q FOODJAR 125 018400397. 9Q 1R02628 025 018500408. 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FOODJRR 12 030600252. 90 1R03688 02S 030708485. 40 F DJRR 13 03G1800243. 70 1 k -j 3689 02S 30900382. 50 FOODJRR 13S 031000480. 60 1RO3690 02S 031100486. 90 FOODJRR 12 031200364. 50 1R03691 02 031300423. 40 FOODJRR 1 2 S 031400388. 80 1R02692 02 031580371. 7Q FOODJRR 13 031600401. 30 1R03693 02S FOODJRR 12 031800312. 20 1R02694 02S 021900513. 50 FOODJRR 125 032000352. 10 1R02695 02S 022100524. 80 FOODJRR 12 S 032200355. 50 99 U 3 12 2 12 2 1*">2 m* 12 13 3 13 S 13 13 3 13 3 13 3 `12 3 13 " 12 s 12 j: 13 3 13 3 12 3 13 3 12 3 12 3 12 2; 12 3 13 0 35 7. 7 421. 7 386. 2 580. 2 371. 2 . 506. 2 276. 9 544. 4 262. 1 480. 4 379. 2 482. 1 376. 5 528. 2 362. 6 503. 1 357. 4 501. 6 265. 3 406. 1 409. 8 515. 4 318. 5 517. 9 350. 9 452. 6 375. 6 475. 9 269. 2 484. 5 353. 9 485. 4 343. 7 382. 5 400. 6 486. 9 364. 5 423. 4 388. 8 371. 7 401. 3 543.0 312. 2 513. 5 252. 1 524. 8 255. 5 BEST COPY AVAILABLE 503 000891 1 YEAR RfiL D 1ET > TOX-ONC STUDY OF FM-3924 & FC-143 IN RRTS EXP. # 0281CR0012 TECHNIC1RN INITIRLSiS MH TODRY'S DRTE : 8/4/81 SEX OF RRTS ;S MftLE ROOM NUMBER :S D --34.- D--338 WEIGHT OF FULL FOOD J R R :S 550GRRMS WEEK 15 1R03516 IS 007280551. 8Q FOODJRR IIS 007300355. 2Q 1R83517 01S 007400491. 00 FOODJRR 11S 007500347. 90 1R03518 01S 007600483. 00 FOODJRR U S 007700391. 30 1R83519 01S 007800531. 70 FOODJFlR 11S 007900380. 30 1R03520 01S 010000517. 20 FOODJflF-l 11S 010100389. 50 1R03521 01S 010200446. 30 FOODJRR 11S 010300374. 50 1R03522 01S 010400465. 80 FOODJFlR 11S 010500393. 20 lr^2523 01S 010600542. 50 F- ..DJRR 11S 01070037O. 90 1R03524 01S 010800481. 90 FOODJRR IIS 018900389. 60 1R03525 01S 011000481. 50 FOODJRR 11S 011100379. 60 1R03526 01S 011200494. 40 FOODJRR 11S 011300391. 90 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 551. 8 355. 2 491 347. 9 483 391. 3 531. 7 380. 3 517. 2 389. 5 446. 3 374. 5 465. 8 393. 2 542. 5 370. 9 BEST COPYAVAILABLE 481. 9 389. 6 481. 5 379. 6 494. 4 391. 9 504 000892 T P TI P T P T * - TI i~> T? f* T G T1 * O G- t" * i~ G e. 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SO IF02-575 0113 021010101447. 80 FOOD JMF: 113 021100247. 30 1R02576 0'13 012120101463. 30 F D JMF: 113 021200248. 20 If:02 577 013 0i2140i0i507. 86 FOOD JMF: 113 012150101223. 10 1F02578 013 01216-01014601. 7t4 FOOD JMF: 113 021700242. 10 !F:o2 5 78 018 021801014801. 70 FoOt'JMF: 113 0218010271. 50 1F025SO till' @22000456. 40 FuODJMF 113 022100268. 46 6 0 2 5 * 1 0123 0O210O433. 00 FOODJMF 123 010`.'201018601. 80 F022`62 028' 0107200352. 50 F O O D J Hr' 128 007400370. 30 IF 02582. 0128' 00 7500339. 30 FOOD JMF: 123 00 7600402. St! 1F02584 023 007700410 20 FOOD JMF' 123' 007800383. 36 1F02585 0i2S 007300422. 20 FO O D JfiR 123 6116101010364. 40 1R03586 023 010100443. 70 FOODJMF' 123 010200370. 30 1F02587 023 0110300372. 60 FOODJMF 123 0101400402. 50 1R02588 023 611015001406. 50 FOODJMF 123 01106001331. 40 J' "i2588 6'2'S 010700416. 30 F O.iHR 123 010800358. 40 1FO2500 6128: 011080161483. 36 FOOL'JMF 123 011000424. 010 1602581 0123 011161012201. 80 FOODJMF 123 011200416. 30 1602582 023 011300471. 80 FOODJMF: 123 011400276. 40 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1` 11 1 11 1 11 1 11 1 11 1 11 2 12 eL 12 12 2 12 2 12 2 12 2 12 2 12 *> 12 12 l! 12 2 12 m 446 3 036. 7 574. 7 2:25 2 413. 2 284 454 3 3:86. 7 465. 5 286. 6 512. 1 372. 5 443 283 540. 1 377. 2 C" 375. 6 435. 8 282. 3 287 466 526. 1 267 512. 1 360 522. 1 374. 2 528. 1 336. 8 447. 8 347. 3 463. 3 248. 2 507. 8 322. 1 468. 7 342. 1 ` 480. 7 271. 5 456. 4 268. 4 433 260. 8 352. 5 270. 3 333. 9 4@2. 5 410. 3 382. 3 422. 2 264. 4 443. 7 370. 3 372. 6 402. 5 406. 5 331. 4 416. 3 358. 4 483. 3 424 330. 8 416. 3 471. 8 376. 4 BEST copy AVAIIABLE 506 C00S94 IF u i 5 9 i 01 R 11500484 tifi FUUL'JHF: l i s 0 1 1 6 -0 0 -c -i. 2U 1R0-594 t i l i 011? 0047-' 1C! r UUl'-'HF: 126 *011800256 40 lk O - 5 9 i U2`S 01100028:3. 10 F UUD JHF: l i s 0120002 45. 80 i r u :596 ti 2. m 11100476 20 F DJRF: 1 1 6 0121006-5. 80 If 0X 012200299. 6-0 r 00D JHF' 126 012400296. IO lF :u 2 5 9 S kl16, *0125010455 10 h U U L'jH k 12S *0126*002 82. 8'-0 1F:0_5'99 016 *0127*0*0425. 80 FUDJHR 12S 0128*3*0281. 40 1R 2600 O2S 01290*0412. 60 FuuDJHR 126 0120*30280. 30 lk *0 x 6 0 1 02S 012100452. 90 FOODJHR 12S 012200262. 20 1R02602 02S *012200418. 90 F L11JL1JHF: 12S 013400279. 10 IF. *03F02 02S 0125*00444. 00 F ODDJ HF' 1 2 s 012 600283. 50 1R03604 02S 0127 O 0276. 70 F'DJRR l i s . 012800295. 10 1 F:0 ! u u 2- 0IS- 13-900411. 50 F u ODJ HF: l l S ' 014000376. 60 1R03606 FDJHF: I l s 014200407. 40 1 F:03-60V7 0 l i 014400442. 40 FOODJHR l i s 014500373. 00 1R*036OS 02s- 014600478. 40 F '"'iDJ F)R l i s 014700256. 40 1 .-26*09 cili 014800406. 00 F UD JHR l i s 014900372:. 60 XF!y s u l F? y l i 01500*04 98. 20 F u ODJh F: l i s 0 1 5 1 0 0 2 6 2 . IO 1K02611 Ul i 0152*9*04*00. *0Gt F uOl.'J RF! l i s 01520*0276. 70 lK y _ - 6 1 i y l i *0154*0*0432. 80 F iju D JRF: l i s *01550*0285. 70 l k y i 61.; y l i 0156*005*09. *00 F o D-Jh R l i s 0157*30268. 6 iF O X 6 1 4 02 S 0158*3*0404. 70 F uuD J h F: Ili *01590*3361. 20 1R02615 Oli- *0160*30374. 90 F OCL'JRF: Ili *016100284. 10 1R03616 ls *316200426. 50 FOODJHR Ili 016200283. 20 1R03617 02S 016400419. 20 FOOD-JHR 12S 016500374. 40 1R03618 02S 016600473. 00 FOODJHR 12S 016700362. 00 1R02619 Oli- 016800354. 40 FOODJHR Ili 016900375. 90 1R02620 OIS 0170*30419. 60 F00DJHR Ili *017100268. 30 1R02621 Oli 017200255. 60 F 'DJRF: Ili 01720*9416. 20 l.v-03622 Oli 017400255. 40 FOOD JHF: Ili 017500393. 90 1F:u262i Oli 017600369. 70 F UODJHR Ili 01778*0388. 00 1R02624 Oli 017800455. 20 FUODJHF: 12S 0179*30257. 90 1R3625 Oli 01800*0342. 20 2 12 2 12 2 12 cL. 12 212 2 12 2 v. 12 2 12 2 12 2 12 2 12 2 12 2 12 2 1 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2! 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 424. 8 265. 2 475. 2 256 4 289. 1 345. 8 476. 2 365. 8 t296. 1 455. 1 282. 8 425. 8 381. 4 412 6 28*3. 3 452. 9 362. 2 418. 9 279. 1 4--4p.4-- 376. 7 295. 1 411. 5 376. 6 390.8 4*07. 4 442. 4 373 478. 4 256. 4 4*36 373. 6 498. 2 363. 1 400 376. 7 432. 8 385. 7 509 368. 6 404. 7 361. 2 374. 9 284. 1 426. 5 382. 2 419. 2 374. 4 473 362 254. 4 375. 9 419. 6 268. 2 355. 6 416. 2 355. 4 293. 9 269. 288 455. 7 2 8 T COPY AVAILABLE 357. 9 342. 2 507 000895 jir*. ii_i. IZ'-T' 0 i1-1002 c 40 JHH c.*Z' kz> 010200460 9C1 k OUL-'.1HF' 123 01Sl00204. 20 lkO'_1*l,' i2S 01640014013. 50 FuUL'jHF: 2 3 0'16 50296. 20 ku2 628 l23 01860101415. 50 F1".'DJHF 12S 01187'O0402. 90 j t*29 k3 01188010'40.S*. 90 t *DJHF 12_- 011080101273. 10 1 :1.1 ijk3 0il901002-00O. 80 OUD.'MF: 23 0l9l0040i6. 4C' lt-'.l.t_l 1*123 01x0 4010i48 - 90 t-!_n_lt Mh. 123 01.0101201. 00! .l_-- Jj:.;3 01940101415. 41;' "'.'HK 123 0i141002 69. 60 _^r.*_*_K-J.~ HJi. 01196010487. 70 -X JRF' 1J O19 7o01268. 90 -".. f ' -I JX'Z' 0`1906iO-342. 10 r :- J:;k ~.z- | *41(i*_i^ jX '_* 'r-'V'_ . ij_<vjkl_(_-.>-y*4, i..( r1:.jLOi * J fclGl x ^xJw XlM x V. U . -i--.-Hk j-c-ir- kl FJJFJIJJ c'.HL-: 1F..*_c - OX 0i40i40i01416*. 90! kC'0LJh F: XX3 u20i5010i267. 50 _i-* 0Z 3 0'10'00101295'. 010 !'-'0'L .*rlk 123 040700287. 010! 1R21 '.'Xi.. 01403001416. 90 FOGD JHk 23 620900372. 2! 1R026401 tjk'Z` 02100'0318. 30 FOOD JHF: 123 014110101419. 70 IR 0*26*41 023 012120101442. 60 FOOD JHF: 23 01212 6101266. 9G! A 2<z-4d 023 021406256. 20. jDJRk 123 014150101291. 10 ikOI-_ 023- 02160101422. 010! HJD JRR 12b 0 4 1 701012-81 60! 1R03644 ti23 0218001295. 90 FOODJRR U S 0i4l90i0274. 80 1R02645 J23 |J42010i01476. 26! F00DJHR 23 022180276. 00! iLf'Z84t' 02 3. 012420101412. 70! FODJHk 123 022200)383. 40 1R01364F ti23 014240101491. 50 FOOD JHF: 1Z-3 0i2250i0'27 7. 70! 1R02648 013 022600572. 30! FODJRR i;s 012270101229. 90 1R02649 3S 022800508. 80-! FD JRR IIS 022900242. 40 lk02 6501 023 0230001441. 010! FDJRF: lx 022100387. 80 1R02651 03S 023200488. 80 FOODJRR 13S 0232010378. 60 1R02652 03S 0224001488. 40! FOODJRR 12 022500276. 20 1R02652 02 323600476. 70! FOODJRR 12 023:700280. 50 1R02604 2 02280101521. 00! F r""'DJRR 12 012290101272. 9G! 1 26:55 0123 0124010101483. 2C! FOOD JRF: 1x3 02410U272. 90! 1F:0i2656 2 01442010518. 10! FOODJRR 12S 01242 010'2701. 90! 1R03657 G2S @*4400492. 20! FOODJRR 12S 0245010382. 10 1R03658 02 01246010447. 40! 12 C12 2 12 2 12 2 12 2 12 2 1J>2 XJ x 12 eL 12 2 12 A3 12 12 2 12 2 12 I, 12 Al 12 2 12 2 12 4 12 4 12 4 13 _ 13 x 13 X12 X 13 3 13 J. 12 J i- 12 s 12 12 . 13 3 13 s BEST COPY m t r 2-88. 4 4601. 9 282 2 4@2. 5 296. 2 415. 5 46'2. 9 469. 9 373. 1 360 9 *.0 6 .4 482 9 2*1*1 415. 4 7' *!' - 2;. 7 3ijj\`i'; 322. 1 389. 9 3s'l.t" 404 457. 9 278. 4 416. 9 367. 5 295 387 416. 9 372. 2 318. 2 419. 7 442. 6 366. 9 356. 3 291. 1 422 381. 6 . 395. 9 374. 8 476. 2 376 413. 7 388. 4 491. 5 377. 7 572. 3 329. 9 508. 8 342. 4 441 387. 8 488. 8 378. 6 488. 4 37t*. 2 476. 380. 521 7 5 BEST COPY AVAILABLE 373. 9 483. 3 372. 9 518. 1 378. 9 495.9 382. 1 447. 4 508 000896 FOOD JftF' X--0- ft-J .ftft-'ftr- 5G( IF'Oft: t j ! " 1 02 9 FC'ftD'JftR 1 2 i XF:Oft` 86*0' ft 2 i- uOC' JftF' 12 2 i f ' : FF.j. 02 3 ft 2 5'2 ft O'4 8 4 .-80 V- OG'D JHF. X2 - 0 2 5<2 0 0 2 7 2 . 40! J 28-62' ft2".5 ft25-40'6'264. 20! 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XF:02-6-76- O'28 '28200550. 50! FOOD-Tftp 12-6 028200364. 30! JR02677' ft26- 0284OJ0490. 6G( FOOD JftF: 1-6 028500269. 80! XF:0J;t-'0- 02 6 028600497. 70! F uOL'JftF: 128 ft26 'O'O'38O'.2Q lPft_8- r'9 O'2S 028800529. IQ FOOD JftF: 128 028900250. 30! lr:t'368i O'28 029000514. 8G-! Fi.'OC'JftR 128 @29100362. 70! XR026oX O'2-6 029200514. 10! FOOD'JftF: 126 029300265. 70! XF'026-6'-X C'2-8 029400408. 60! FOOD-JftR 128 G'2950'0410. 90! 1R026S3 038 029600526. 30! FOODJHR 128 029700350'. 0Q 1R02684 028 029800531. 7Q FOOD'JftF: 128 029900351. 70! 1R03685 028 020000464. 20! FOOD-JftR 128 020100261. 40! XF:O_6o6 O'28 02-O200490. 10! FOOD JftF' 128 030300363. 90! 1R02687 O'38 020400495. 40! f 'L'JftF: 128 0305O0367. 10! X. .-J2688 0'28 020600490. 00! F Out 'JftF: 128 o3O'/00255. 70! IF:ft28-83 02 6- 030800287. 10! FOOD1JftF: 128 020900284. 40! 1K03690 028 021008495. 10! FOODJftR 128 021100362. 3Q 1R03691 028 0^-1200422. 60! 13 3 13 ji- 13 13 j. 12 6 13 312 j 13 2- 13 6 13 - 13 13 13 3 12 s 13 3 13 13 J13 . 13 s 13 13 13 13 13 ji13 2 13 3 12 3 13 13 *<; 13 3 13 13 j. 13 3 406. 5 484.4 366.6 508.0 371.1 484. 8 272 4 364 3 417. 1 554 359. 9 420' 413. 2 459. 6 392. 5 479. 4 366. 4 371. 5 401. 9 374. 9 364. 7 499. 5 375. 6 523. 7 335. 7 460. 2 365. 9 489. 7 372. 2 436. 8 383. 5 50'6. 8 372. 4 518. 2 383. 9 550'. 5 364. 3 490. 6 369. 8 497. 7 380. 3 539. 1 350. 3 514. 8 362. 7 514. 1 365. 7 408. 6 410'. 9 526. 3 350 531. 7 351. 7 464. 2 361. 4 490. 1 363. 9 495. 4 367. 1 490' BEST COPY AVAILABLE 355. 7 387. 1 384. 4 495. 1 362. :< 432. 6 509 000897 FOODJRR 13S 0313010384. 30. 1R02692 03S @314083-82. IQ FOODJRR 1 2 S 831500400. IQ 1R83693 02S 021.600569. Q FOODJRR 13S 031700342. 3:ij! 1R02694 03 8318010522. 0i-! FOODJRR 12S 03190035c.. ;1'"03695 02 S 832000532. 70. ( jDJRR 13 832180'254.70. '4'4 12 13 2 13 s 12 . 13 0 284. 2 282. 1 400. 1 569. 2 -4^!. S 522 256. 2 532. 7 254. 7 BEST COPY AVAILABLE 510 000898 TWO VEftF- ORAL <D i m TOX-ONC SI UDV OF FM-3924 4. FC-143 IN RATS EXP. ft O2S1CR0012 TECHNICIAN INITIALS:S MH TODAY'S DATE : 8/11/81 SEX OF RAT S :S MALE ROOM NUMBER :S D-340, D-23-8 WEIGHT OF FULL FOOL J A R :S 550GF:AHS WEEK 16 1F0351* 01S 0O700O556. 80 FOODJAF: 11S 00 "'100261. SO 1R03517 01S 0*3720*3498. 00 FOOL JAF: U S 00 7300266:. 70 1R03518 01S 007400481. 50 FOODJAF: 115 OO75O0295. 20 1R02519 01S 007600542. 00 FOODJAF: IIS 0077O02 78. 80 1R0252C1 0i 007800525. 20 FOOD TAP IIS 0078OO288. 60 1F03521 01S O1OOO0452. 6:0 FOODJAF: 115 010108282 60 1F02522 015 010200476. 7o F OOD JHP 115 010200282 60 1F03523 01: 010400541. 20 FOOD-JAR 115 0105'r0783 50 XP02524 015 01060046? 10 FOODJAF 115 Cx *37002-87. 50 1F.02525 Ox* 1 JDJAF: 1-- _ 01!-i?L*''--1_ ^70 . 10! 1R0252. OlS Cxj..>w*t98. -U FOO Mr' 1j__' i x | Cuxiut'-i Vi. _ 0 rc-::. >;.. xx.r- 8x1x6*'2 3i. . - f:CI _C O-M i-'ilH 5 20 r , l ' . ,. ii. fix! ':'257. 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GQ FOODJAR 11S 012800359. 3G 1R03535 01S 012900508. 7Q FOODJAR 11S 013000391. 3Q 1R03536 01S 013100497. 9G FOODJAR I I S 012200417. 2 Q 1R03537 01S 013300504. 2 Q FC JAR 11S 012400388. 0 G 1R3528 01S 013500668. 4Q FOODJAR 11S 013600371. 8 1R03529 01S 013700502. 6 G FOODJAR I I S 013800387. 8 Q 1R0254G 01S 013900528. 5G FOODJAR 11S 01400 0395. 6 Q 1R03541 01S 014100595. 4G 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 li 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 642. 1 370. 3 574. 3 369. 7 560. 7 388. 8 582. 6 376. 9 591. 2 375. 4 507. 9 416. 5 551. 8 390. 6 625. 6 377. 3 560 373. 3 559. 2 374. 6 588. 1 378. 8 .552. 6 396. 6 642. 7 361. 6 581. 3 378 557. 7 388. 3 585. 2 295. 5 589. 3 389. 5 601. 7 392 650 359. 3 508. 7 391. 2 497. 9 417. 2 504. 2 388 668.4 371. 8 502. 6 287. 8 528. 5 395. 6 595. 4 BEST COPY AVAILABLE 583 C00971 FDJF: U S 014200374. 4Q 1803542 01S 014300564. 70 FODDJ hF: U S 014400376. 2G 1R03543 0 1 S 014500672. 40 FOODJF: U S 014600339. 00 1R03544 OIS 014700633. 10 F C ' 'JftR U S 014800352. 80 IF... _-545 01S 01490 0621. 10 FOODJF. 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596. 8 381. 1 653. 1 368. 7 658 363. 1 531. 7 386. 5 530. 2 406. 6 428 403. 4 638 340. 8 645. 5 360. 8 453. 4 398. 3 563. 5 378. 2 647 378. 7 536. 8 391. 3 497. 2 380. 9 554. 2 393. 1 . 539. 4 381 671 353. 6 507. 3 398. 2 517. 5 378. 9 551. 8 367. 3 626. 6 360. 6 493.0 395. 9 672. 5 364. 6 622. 9 362. 7 652. 1 359. 3 577. 1 I 363. 8 625. 8 BEST COPY AVAILABLE 361. 2 570. 9 346. 6 627. 8 376. 5 545. 4 584 C00372 FOODJAP 115 02080 0313. 70 1R03575 01S 020900519. 40 FOODJflR 11S 021000361. 90 1R03576 0 1 S 021100540. 60 FOODJflR 11S 021200378. 2 0 1R03577 01S 021300574. 90 FOnDJflR I I S 021400373. 60 I f .578 01S 0215O0565. 2 0 FOODJflR. 115 021600354. 1 0 1R03579 01S O21700573. 0 0 FOODJflR 11S 021800366. 2 0 1R03580 015 021900549. 70 FOODJflR 118 022000375. 0 0 1R83581 02S 0 0 '100576. 2 0 FOODJflR 125 007200362. 90 1R03582 025 007300411. 2 0 FOODJflR 125 00740 0390. 4Q 1R03583 025 007500423. 2 0 FOODJflR 125 00760 0383. 80 1R03584 825 0 0770 0466. 5Q FOODJflR 125 00780 0 3 8 9 . 0Q 1R03585 025 007900506. 90 FOODJflR 125 01000 8366. 50 1R03586 025 010100534. 0 0 FOODJflR 125 01020 0371. 60 1R03587 025 010300441. 2 0 FOODJflR 010400398. 30 1R0358S 025 010500501. 80 FOODJflR 125 010600369. 2 0 1R03589 025 0 1070 0479. 4Q FOODJflR 125 01080 0372. 80 1R03590 0 2 S 010900000. 0 0 RAT # 1R03590 025 FOODJflR 125 0 1 1 0 0 0 0 0 0 . 0Q 1R03591 0 2 S 011100394. 60 FOODJflR 125 01120 0384. 00 1R03592 0 2 S 011300545. 7Q FOODJflR 125 01140 0375. 80 1R03593 025 011500495. 3Q FOODJflR 125 01160 0372. 7Q 1R03594 025 0 1170 0545. 6Q FOODJflR 125 0 1180 0361. 60 1R03595 025 0 1190 0450. 5Q FOODJflR 125 0 1200 0399. 2Q 1R03596 0 2 S 0 1210 0572. 2Q FOODJflR 125 81220 0361. 5Q 1R03597 025 0123 0 0 4 6 6 . 5Q FOODJflR 125 01240 0404. 40 1R03598 025 0 1250 0511. 4Q FOODJflR 125 0126 0 0 3 8 4 . 70 1R03599 0 2 S 01270 0 4 8 9 . 6Q FOODJflR 1 2 S 01280 0370. 4Q 1R03600 0 2 S 0 1290 0494. 9Q FOODJflR 1 2 S 0 1 3 0 0 0 3 7 4 . 0Q 1R03601 0 2 S 0 1 3 1 0 0 5 5 1 . 6Q FOODJflR 1 2 S 01320 0 3 6 8 . 5Q 1R03602 0 2 S 01330 0515. 6Q FOODJflR 125 01340 0362. 5Q IF 603 0 2 S 13500519. 20 FOODJflR 1 2 S 0 1360 0379. 80 1R03604 025 013700472. 70 FOODJflR 125 01380 0392. 30 1R03605 025 01390 0 4 7 6 . 7Q FOODJflR 125 01400 0 3 7 9 . 30 1R03606 025 0 1 4 1 0 0 4 3 6 . 0Q FOODJflR 125 0 1 4 2 0 0 4 1 3 . 80 11 1 11 1 11 1 11 1 11 1 11 1 11 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 010900000. 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 313. 7 519. 4 361. 9 54. 6 378. 2 574. 9 373. 6 565. 2 354. 1 573 366. 2 549. 7 375 576. 2 362. 9 411. 2 390. 4 423. 2 383. 8 466. 5 389 506. 9 366. 5 534 371. 6 441. 2 398. 3 501. 8 369. 2 479. 4 372. 8 0 NOT ON STUDY 0 394. 6 384 545. 7 375. 8 495. 3 372. 7 545. 6 361. 6 450. 5 399. 2 572. 2 361. 5 466. 5 404. 4 511. 4 384. 7 489. 6 370. 4 494. 9 374 / li 362. 5 519. 2 379. 8 472. 7 392. 3 476. 7 379. 3 436 413. 8 BEST COPY AVAILABLE 585 000973 1R63607 02S 014300523. 50 FOODJR 12S 014400383. 0 0 1R02608 02S 814500564. 80 FOOL1JF' 12S 014600367. 0 0 1RO3609 0 2 S 014700479. 80 FOODJR 12S 014800378. 90 I P - -610 0 2 S 014900580. 30 FG. ..JR 12'3 015000367. 0 0 1R02611 02S 015100522. 80 FOODJF' 1 2 S 015200373. 50 1R02612 023 015308513. 70 FOOD1JR 123 015400388. 90 1R03613 023 015500607. 50 FOODJFiR 123 015600375. 80 1R03614 0 2 S 015700491. 60 FOODJR 123 015800375. 70 1R03615 023 015900482. 30 FOODJR lfi 016000377. 60 1R03616 023 016100517. 1 0 FOODJR 123 016200362. 1 0 1FI03617 0 2 S 016300496. 1 0 FOODJR 123 016400381. 90 1R03618 023 016500591. 80 FOODJR 123 016600368. 60 1R03619 023 016700435. 60 FOODJR 123 016800389. 1 0 1R02620 0 2 S 016900531. 30 FOODJR 123 817000362. 50 1R03621 023 017100424. 2 0 FOODJR 123 017200414. 80 1 0 362 2 02S 01730 0417. 3Q FOODJR 123 017400395. 1 Q 1R03623 023 817500493. 0 0 FOODJR 123 017600374. 30 1R03624 023 017700541. 30 FOODJR 1 2 S 017800365. 6 Q 1R03625 023 017900000. 0 0 RT # 1R03625 02S FOODJR 123 018000000. 0 0 1R03626 023 018100529. 90 FOODJR 123 018200381. 90 1R03627 023 018300505. 50 FOODJR 123 018400388. 30 1R0362S 023 018500490. 50 FOODJR 123 018600397. 1 0 1R03629 023 018700555. 60 FOODJR 123 018800370. 50 1R03630 0 2 S 018900444. 90 FOODJR 1 2 S 019000396. 50 1R03631 0 2 S 019100551. 70 FOODJR 123 019200373. 6 Q 1R03632 0 2 S 019300513. 5Q FOODJR 1 2 S 01940 0371. 1 0 1R03633 0 2 S 019500566. 2 0 FOODJR 1 2 S 01960 0354. 4Q 1R03634 0 2 S 019700399. 5Q FOODJR 1 2 S 019800380. 3Q I R --<635 023 019900435. 40 Ft. .'JAR 123 020080394. 4Q 1R03636 023 020100526. 50 FOODJR 123 020200378. 30 1R03637 0 2 S 820300503. 30 FOODJR 123 020400365. 40 1R0363S 023 020500478. 30 FOODJR 123 020600387. 6 Q 1R03639 023 820700446. 50 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 . 12 2 12 2 12 2 12 Z 12 2 12 2 12 2 017900000. 90 12 2 12 2 12 2 12 '2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 12 2 533. 5 383 564. e 367 479. 8 378. 9 580. 3 367 522. 8 373. 5 513. 7 388. 9 607. 5 375. 8 491. 6 375. 7 482. 3 377. 6 517. 1 362. 1 496. 1 381. 9 591. 8 368. 6 435. 6 389. 1 531. 8 362. 5 424. 2 414. 8 417.3 395. 1 493 374. 3 541. 3 365. 6 0 NOT ON STUDS' '0 529. 9 381. 9 505. 5 388. 3 490. 5 397. 1 555. 6 370. 5 444. 9 396. 5 551. 7 373. 6 513. 5 371. 1 566. 2 354. 4 ! ! BEST COPY AVAILABLE 394. 4 526. 5 378. 3 503. 3 365. 4 478. 3 387. 6 446. 5 586 C00374 FOODJ AR 12S 020880393. 40 1R03640 0 2 S 020900379. 30 FOODJAR 12S 0210G0420. 0 0 1R03641 02S 021100509. 80 FOODJAR 125 021200281. 0 0 1R03642 025 021300451. 60 FOODJAR 12S 021400412. 90 11 643 025 021500537. 2 0 FOODJAR 125 021600279. 30 1R03644 025 021700453. 90 FOODJAR 125 021800374. 2 0 1R03645 025 021900544. 1 0 FOODJAR 1 2 S 022000274. 50 1R03646 035 G22100485. IQ FOODJAR 135 022200398. 1 0 1R03647 035 022200505. 40 FOODJAR 135 022400391. 4Q 1R0364S 03S 022500668. 40 FOODJAR 13S 022600350. 70 1R03649 03S 022700583. 7Q FOODJAR 135 022800367. 90 1R03650 035 822900500. 2 Q FOODJAR 135 023000392. 80 1R02651 03S 024100580. 9Q FOODJAR 13S 023^200374. 80 1R03652 035 022300591. 80 FOODJAR 135 023400372. 1 0 1R02653 035 023500568. 70 FOODJAR 135 02360 0375. 5G 1R03654 035 023700598. 3Q FOODJAR 125 023800377. 30 1R03655 035 023900566. 60 FOODJAR 135 024088384. 4Q 1R03656 025 024100589. 6 Q FOODJAR 135 024200274. 70 1R.03657 035 02430 0572. 5Q FOODJAR 125 024400389. 9Q 1R03658 035 02450 0496. 8Q FOODJAR 135 024608398. 2 0 1R03659 03S 024700598. 70 FOODJAR 125 024800357. 9Q 1R03660 035 024900583. 4Q FOODJAR 13S 02500 0382. 3Q 1R03661 03S 02510 0576. 9Q FOODJAR 135 02520 0369. 8Q 1R03662 03S 02520 0409. 2Q FOODJAR 13S 02540 0407. 3Q 1R03663 035 025500603. 20 FOODJAR 13S 02560 0381. 9Q 1R03664 03S 02570 0 4 8 5 . 2Q FOODJAR 135 02580 0399. 30 1R03665 03S 025900520. IQ FOODJAR 13S 02600 0393. 8Q 1R03666 03S 02610 0566. 8Q FOODJAR 125 026200378. 7Q 1R03667 0 2 S 02630O443. 6Q FOODJAR 135 02640 0396. 2Q 1R02668 03S 026500454. IQ FC JAR 135 02668 0401. 6Q 1R03669 025 026700596. 7Q FOODJAR 125 0 2680 0370. 7Q 1R03670 035 0 2690 0599. 8Q FOODJAR 13S 027000372. 80 1R03671 03S 027100531. 7Q FOODJAR 135 02720 0383. 8Q 1R03672 03S 02730 0589. 9Q 12 2 12 2 12 2 12 2 12 ti 12 e* 12 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 393. 4 279. 2 420 509. 8 381 451. 6 413. 9 527. 2 379. 3 452. 9 374. 2 544. 1 374. 5 485. 1 398. 1 505. 4 391. 4 688. 4 250. 7 583. 7 367. 9 500. 2 392. 8 580. 9 374. 8 591. 8 372. 1 568. 7 375. 5 598. 3 277. 3 566. 6 384. 4 589. 6 374. 7 572. 5 389. 9 496. 8 398. 2 598. 7 357. 9 583. 4 382. 3 576. 9 369. 8 409. 2 407. 3 603. 2 281. 9 485. 2 399. 3 520. 1 ill I BEST COPY AVAILABLE 378. 7 443. 6 396. 2 454. 1 401. 6 596. 7 370. 7 599. 8 372. 8 531. 7 383. 8 589. 9 587 000975 FOODJfiR 13S 027400374. 0Q 1R03673 3-S 027500527. IQ FOODJFIR 13S 027600387. 70 1R03674 03S 027700611. 3Q FOODJfiR 13 027808376. IQ 1R03675 03S 027900590. 9Q FP" ~'JfiR 13 S 028000362. 4Q 1 R. ^67c" 03 S 028100648. 90 FOODJfiR 13S 028200372. 20 1R03677 03S 028300574. 00 FOODJfiR 13S 028400382. 40 1R03678 03S 02850 0549. 9Q FOODJfiR 13S 028600401. 40 1R03679 03 S 028700654. 30 FOODJfiR 13 028800345. 90 1R0368O 03 028908590. 00 FOODJfiR 13S 029000366. 00 1R03681 03S 029100545. 00 FOODJfiR 13 029200365. 20 1R03682 03S 029300459. 60 FOODJfiR 13S 029400405. 60 1R83682 03S 029500631. 4Q FOODJfiR 13 029600348. 90 1R03684 03S 029700624. 20 FOODJfiR 13 02980 0367. 90 1R03685 03S 029900531. 20 FOODJfiR 13S 030000383. 50 1R03686 03 030100583. 10 FOODJfiR 13 030200374. 9Q 1R03687 02S 030300600. IQ FOODJfiR 13 030400362. 7Q 1R03688 03 030500587. 9Q FOODJfiR 13 030600378. 5Q 1R03689 03-S 03070 0423. 70 FOODJfiR 13 030800397. 20 1R03690 03 030906564. IQ FOODJfiR 13S 031000370. 9Q 1R03691 03 031100486. 00 FOODJfiR 13S 031200379. 30 1R03692 03S 031300465. 50 FOODJfiR 13S 031400392. 4Q 1R83693 03S 031500643. 40 FOODJfiR 13S 03160 0370. 5Q 1R03694 03S 031700566. 4Q FOODJfiR 13S 031800388. 20 1R03695 03 03190 0606. 0Q FOODJfiR 13S 032000360. 3Q 9999999999 99 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 0 374 527. 1 387. 7 611. 3 376. 1 590. 9 362. 4 648. 9 372. 2 574 382. 4 549. 9 401. 4 654. 3 345. 9 590 366 545 365. 2 459. 6 405. 6 631. 4 348. 9 624. 2 367. 9 531. 2 . 383. 5 583. 1 374. 9 600. 1 362. 7 587. 9 378. 5 423. 7 397. 2 564. 1 370. 9 486 379. 3 465. 5 392. 4 643. 4 370. 5 566. 4 388. 2 606 360. 3 BEST COPY AVAILABLE 588 000976 Mi H i a; cj rH 2-4 3 LL ri O *T r i r i '.0 1 'il O '3 li. 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X r-J Ui --i r i o3 l"l U. Xk-, I-.J Ui i r i **> UT Ui I l ui l'I o 3 '-- 3 1 LL O iL tH II H X r i I I r i LL r i LL H X r i LL tH X rH u. H X -1 X H l ri X rH 3i1030 3'3 3UT r3i 3'3 Grl G00 *GXlGi" 3N 30 U3T '3Tl GIi 1G0 3rl 3i 3X 3G o a ''l3riH 3 'Ti ur-33ii <'33 '''r'i*T)-333-i)'U<'T33Ti'U'>nlS-33TiS 3 `*33 3'3 ''''Ur0533Ti513'Jlr-3iii 3 3<3 0'3 >i>0335 ?.. 3>3 OJi JX>i3i'i (\. 3'3 >'00'r0333i55 r>i3 Hr'330H3 rii3 f'- CUTJ f. li 33'a3i3 rH rH 3 X' 1t3 IO 3 tI rH '3 >'U'33rrT'3SHH '3 U>Cr'r33T3H3Oi IM j 3[3'I3Ti-i33N''0o 3 3 3rN-Hi jOii 3 UT i JiiDii U3r"' '3 ri X'T ri r rri Cr /I rriH Mrii 3 Mrii rH 0r13i CCl rH diH3 o'rrHl crHi arrHHi e3rnH r0rlH1 orOHi orHli eXrinH 0r1H H 1/1 3ri MrriHl erH3n erHHn orli '3 ernl ri cre X LX1--L, G i" li ,r*| ri i ri 3 il. ri LL Xu , ui o IL rH Ii u> l'3I LL ri lL X ili o o IL I'liOi Pi S' LL H XX -. 3OOX IllOii i3i LrLi XX COOXi UiTTi ii riil! IXL GO O u. UlUTiT Xir r, Ul0Ti5 X1C--f,' r._ rUTi XU-,' ll||'-iO| XX Pi G i i PI G r-iG 3 - OO rH I I `3 LL H Ll 3 , o LL ri LL XrH LOl Ji lVl LXL 3i ru:i CHaL* L*GOO-l iiCXrvr- F O u t 'J f l R l b . 1 1 : 00: 9 1 . 60 ir s : 541 019 0114O6O5. 20 F O O D JflR 1 1 s 0 115 0 0 : 7 : . 40 ir o : 542 019 011600564. 70 F O O t JH R 1 1 9 0 1 1 7 0 0 3 8 9 . 00. ir o : 54: 019 O11800670. 50 F ' L JA R n s 0 119 0 0 : 8 5 . 10 i , 5 4 4 0 1 S 0 1 2 0 0 0 6 4 1 . 8 0 F O u t'JflR I I S 0 1 2 1 0 0 :4 7 . 5 0 1R*5. 5 4 5 0 1 9 .0 1 2 2 0 0 6 2 0 . 4 0 FO U L JAR 1 1 2 0 1 2 2 0 0 2 7 4 . 2 0 i p .o : 5 4 6 0 1 2 0 1 2 4 O 0 6 0 7 . 0 0 F O O t JflR 1 1 2 0 1 2 5 0 0 :7 9 . 5 0 ir o : 547 012' *912600671. 00 Foot JflR 1 1 2 0 1 2 7 0 0 3 7 0 . 6 0 1 R 0 I 5 4 8 0 1 2 0 1 2 8 0 0 6 6 6 . O Q FO O t 'JflR I I S 0 1 2 9 0 0 2 6 7 . 80 ir o : 549 012 01300O 53O . SO FO O t JflR 1 1 2 0 i : i 0 0 : 9 2 . 7 0 i r o : 550 0 1 2 0 1 :2 0 0 5 2 5 . 4 0 FO O t 'JflR 1 1 2 0 1 2 :0 0 2 9 7 . 50 ir o : 551 012 013400432. 60 FO ir O o t : eJrfel R 112 012 013500404. 40 013600645. 90 F O O t ' JflR 1 1 2 0 1 3 7 0 0 3 4 0 . 0 0 i r o : 5 5 8 0 1 2 0 1 3 8 0 0 6 5 0 . 2 0 F O O L 1J f t F : 1 1 2 0 1 3 9 0 0 3 5 8 . 1 0 i r o : :5 5 4 0 1 2 0 1 4 0 0 0 4 5 6 . 1 0 FO ir O o t : _esJjfcl:Rtrj 112 012 01410*11401. 0 0 01420O578. 20 F O O D JflR 1 1 2 0 1 4 2 0 0 3 7 8 . 2 0 1R0I 556 012 014400654. 50 F O O D JflR 1 1 2 0 1 4 5 0 0 3 7 6 . 0 0 i r o : 557 0 1 2 0 1 4 6 0 0 5 4 4 . 9 0 FO ir O o t : crJefrlRci 112 012 014700388. 30 01480050O. 30 F O O t J m F: 1 1 2 * 5 1 4 9 0 0 3 8 4 . 7 0 i r o : -555* 0 1 2 0 1 5 0 0 * 5 5 5 2 . S O FOOL'JftF! 1 1 2 *5 1 5 1 0 0 3 9 0 . 8 0 i r o : 5t* *512 . 1 5 2 0 *5 5 3 9 . 0 0 FO O t 'JflR 1 1 2 01 53 *5 04 02. 7 0 i r o : 5 8 1 6 1 2 *51540*5675. 50! FO O t JflR 1 1 2 015501*5349. 7 0 -i r o : 5 6 2 0 1 2 * 3 1 5 6 0 1 0 5 1 3 . O Q FO O D JftF: 1 1 2 0 1 5 7 0 0 3 8 4 . 7 0 ir o : 563 012 01580052*5. 40 FOOt JflR 11 2 01590*3376. SO ir o :-564 0 1 2 0 1 6 0 O 0 5 6 6 . 5 0 F O O D JflR 1 1 2 0 1 6 1 0 0 3 6 5 . 6 0 1R03565 012 01620/622. >S F O O D JflR I I S 0 1 6 3 0 0 3 7 1 . 90 i r o : ;5 6 6 0 1 S 0 1 6 4 0 0 4 8 9 . 2 0 F O O D JflR 1 1 2 0 1 6 5 0 0 3 9 9 . 1 0 1R03567 012 016608676. 90 FO O t 'JflR 1 1 2 0 1 6 7 0 0 3 6 0 . 50 ir o : 568 012 01680*3628. 10 F O O t JflR 1 1 2 0 1 6 9 0 0 3 5 9 . 3 0 "0: :5 6 9 3 1 2 0 1 7 0 0 * 3 6 4 5 . 7 0 . u O t JflR 1 1 2 0 1 7 1 0 0 3 2 9 . 8 0 1R 03578 012 0172*30578. 60 F O O t JflR 1 1 2 0 1 7 3 * 3 0 3 1 9 . 8 0 ir u : 571 012 0174*30624. 90 FO O t JflR 1 1 2 6 1 7 5 0 0 3 6 8 . 00 i r o : 5 i' *3 1 2 0 1 7 6 0 0 5 7 5 . 2 0 F O O D JflR 1 1 2 0 1 7 7 0 0 3 7 4 . 7 0 1p Pi~S 7 " F li ftiD 11 1 11 1 11 1 11 1 11 - 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 2 9 1 . 6 *3 5 . j-. 373. 4 5 6 4 . -7 289 670. 5 225. 1 641. 347. 8C| 626. 4 3 7 4 . .* 607 279. 5 671 37*3. 6 666 367. 8 530. 8 292. 7 525. 4 297. 5 422. 6 404. 4 6 4 5 . St 240 650. 2 258. 1 456. 1 401 578. 3 378. 2 654. 5 376 544. 9 388. 3 50*3. 384. 7 553. 8 390. 8 539 403. 7 675. 5 349. 7 512 384. 7 520. 4 376. 8 566. 5 365. 6 632 371. 9 489. 2 299. 1 676. 9 360. 5 628. 1 359. 3 6 4 5 . i" BEST COPY AVAILABLE 339. 8 578. 6 219. 8 624. 9 368 575. 2 374. 7 A 590 C00978 FOOD JHR H i 01790 0 ^6 8, OC! 11 1R03574 OIS . 100O522. 90 1 FOOL*JftR; 118 018100317. SO 11 1R02575 OIS 018200521. 10 1 FOIL'DJftR: I I S 018200353. 40 11 1R02576 01S . 18400547. 70 1 FOODJftR! I I S 018500378. 70 11 0 2 0 7 7 ' 01S 018600574. 50 1 ROODJftR I I S 018700377. 80 11 1R02578 01S 0 1 8 8 0 0 5 61. .50 1 FOCiDJftk I I S 018900358. 20 il 1R.02579 01 . 019000581. 60 1 FOODJftR; 11S 019100367. 80 11 1R3-58 01S 019200549. 00 1 FOODJftR 11S 019300372. 10 11 1R1581 02S . 0 7100583. 60 2 FOODJftR 12S 00 7200371. 10 1; 1R92582 02S 00 7300412. 40 2 FOODJftR 12S 00 7400295. 50 12 1R01582 02S . 07500435. 20 2 Fu ODJftF; 12S 007600388. 10 12 1R02584 02S . 0 7700475. 70 2 FOODJftR 1 2 S 00 7800285. 70 12 1R02585 0 2 .3 2 FOOL1JHR 12S 00 7100363. 60 12 1R01586 02S . 0 7200537. 80 2 FOODJftR 12S 0072'00284. 10 12 1R03587 02S 0 740446. 80 2 FOODJftR 12S 00750042. 90 12 1R03588 02S 007600503. 30 2 FODDJ HR 12S 00 7700282. 90 12 1R02589 02S . 0 7800482. 80 2 FOODJftR. 12S 07900272. 90 12 1 R 0 I5 8 0 02S 010000000. 0Q 2 RftT # 1R.02590 02S 010000000. 00 FOODJftR 12S 010100000. 00! 1R02591 02S 010200293. 10 2 FOODJftR 12S 010200281. 90 12 1R03592 02S . 10400561. 40 2 FOOt1JftR 12S 010500272. 80 12 1R02592 0 . 10600494. 10 2 FOODJHR 1 2 S 010700386. 20 12 1R03594 02S . 10800548. 80 2 FOODJftR 12S 010900373. 50 12 1R02595 02S 011000454. 20 2 FOODJftR 12S 011100296. 60 12 1R03596 02S . 11200582. 60 2 FOODJftR 12S 011200362. 70 12 1R02597 02S 011400464. 80 2 FODDJftR 12S 011500405. 90 1R0359S 02S 011600514. 90 12 2 FOODJftR 12S 011700382. 00 12 1R02599 02S 011800500. 70 2 FOODJftR 12S 011900374. 60 12 1R02600 02S 012000505. 90 2 FOODJftR. 12S 01210 0377. 90 12 iLF!0 j-60iL 02S . 12200551. 20 2 FOODJftR 12S 012200279. 50 12 1 3602 02S . 12400524. 90 2 FOODJftR 12S 0 1250 0374. 60 12 1R03602 02S . 12600537. 20! FOODJftR; 12S 012700386. 40 12 1R02604 02S . 12800485. 50 2 FOODJftR 12S 012900298. 80 12 1R03605 02S 013000482. 60 2 FOOt* JftR; 12S 01310 0386. 30 12 369 522. 9 317. 8 521. 1 253. 4 547. 7 378. 7 574. 5 377. 8 561. 5 358. 2 581. 6 267. 8 549 372. 1 583. 6 271. 1 413. 4 295. 5 425. 2 288. 1 475. 7 385. 7 5 1 2 .5 363. 6 537. 8 284. 1 446. 8 402. 9 563. 3 382. 9 482. 8 373. 9 0 NOT ON STUDV 0 393. 1 . 381. 9 561. 4 372. 8 494. 1 386. 2 548. 8 373. 5 454. 3 296. 6 582. 6 263. 7 464. 8 405. 9 514. 9 500. 7 374. 6 505. 9 377. 9 551. 2 379. 5 524. 9 174. 6 527. 2 386. 4 485. 5 398. 8 482. 6 286. 3 BEST COPY AVAILABLE 591 000979 lR0_;.60t. 022. 01^10 0 4 4 0. 20 FOODJflR 122. *011300418 00 i f 026 o r 02S 13400042. 5*0 FOODJflR 122. 012000377. 80 1R03608 02 S 013 600575. 80 FOOD JmF: 122 0 1 3 .0 0 3 6 4 . 80 12 12 3 12 1r 2O? 022 013800482. 10 F'_ ..0 JmF: 122 01380*3377. 40 1P.03610 022 *314*30*3585. 10 FOOD JmF: 122 14100375. .30 12 12 1R03611 022 . 14200524. 20 FOOD JRF: 122 0142*3*33 72. 50 12 1R03612 022 *3144*30526. 80 2 FOODJflR 122 *31450*3378. 20 12 1R03613 022 014600612. 80 .* FOODJ hF: 122 *314700378. 0 12 1R03614 022 *31480*3483. 70 FOOD JmF: 122 0148*30275. 50 12 1R02615 022 *3150*30488. 10 FOODJ mF: 122 0151*30375. 80 2 12 1R02616 022 0152O0522. 10 2 FOODJflR 122 81530 0372. 20 12 1R03617 022 0115400505. 80 2 FOODJflR 122 01550*3282. 70 12 1R03618 022 *315601*3601. 00 cl' FOODJflR 122 015700365. 60 12 1R02619 022 *315801*3453. 80 FOODJflR 122 015880286. 60 12 1R03620 22 016*300542. 40 2 FOODJflR 122 *3161*30366. 20 12 1R02621 022 . 162*30433. 60 2 FOODJflR 122 016300412. 20 12 104622 02S O1640O426. 50 2 FOODJflR 122 *3165*30286. 20 12 1R03622 022 *3166*301503. 20 FOODJflR 122 *3167*3*3377. 40 2 12 1R02624 022 *316.8*3*3550. 60 2 FOODJflR 122 011680*3268. 40 12 IF :03628 022 0170*30*3*3*3. 00 2 RAT # 1R03625 2S 017000000. 00 FOODJflR 122 01710*3000. 0 12 1R02626 022 017200543. 00 2 FOODJflR 122 `31730*3377. 40 12 1R03627 022 0174*30518. 70 2 FOODJflR 122 017500282. 80 12 1R02628 022 017600502. 20 2 FOODJflR 122 *317700385. 20 12 1R03629 022 017800567. 50 2 FOODJflR 122 017800373. 30 12 1R03638 022 *318000452. 10 FOODJflR 122 018100286. 60 2 12 1R03631 022 . 18200562. 00 2 FOODJflR 122 018300273. 80 1R03632 022 018400504. 70 12 2 FOODJflR 122 1185*30387. 30 12 1R03633 022 0186*30587. 50 2 FOODJflR 122 31870*3364. 70 12 703634 22 *318800408. 00 2 . JODJflR 122 0188*30285. 50 1R03635 022 18000443. 20 12 2 FOODJflR 12 *318100402. 20 12 1R03636 022 018200/40. 80 2 FOODJflR 122 018300378. 10 1R03637 022 018408512. 80 ForiD TFlfc1 1 Fv1 ftfj 12 2 1P 440. 2 418 542. 8 377 8 575' 8 364. 8 482. 1 377. 4 585. 1 75. 3 534. 2 372. 5 52. 8 378. 2 612. 8 378 483. 7 375. 5 488. 1 375. 8 522. 1 372. 2 585. 8 382. 7 601 365. 6 453. 8 386. 6 542. 4 366. 2 433. 6 413. 2 4 2 6 .5 386. 2 5*33. 2 377. 4 550. 6 368. 4 0 NOT ON STUDV 0 543 377. 4 519. 7 382. 9 503. 2 95. 2 567. 5 373. 3 452. 1 396. 6 562 373. 9 504. 7 87. S 587. 5 364. 7 BEST COPY AVAILABLE 408 385. 5 443. 2 402. 2 5 4 0 .8 378. 1 512. 8 77ft ft 592 C009S0 1R02628 IV--- 0186610482. 70-! FOODJRR 12 8 01870 0292. 90 1R o 2 2 y 022. 018800466. 40 FOODJRR: 125 01980 0292. 40 1RG3640 025 01010001284. 10 FOODJ RR 125 02010 0421. 00 1R83641 029 02020 0508. 70 :ODJRR 125 028200287. 90 1R82642 1025 020400471. 90 F'OODJRR 125 820500285. .80 1RGG642 '25 82068 0543. 20 FOOC1JRR 125 020700388. 30 1R02644 025 . 28800475. 80 FOODJRR 125 0209010375. SO 1R82645 025 021008554. 70 FOODJRR 125 02110 0272. 00 1R03646 025 021200581. 70 FOODJRR 125 02120 0290. 20 1R02-647 023 01140O515. 10 FOOC' JRF: 125 021508358. 70 1R03648 025 02168. 675. 20 FOOC'JftR 125 021700348. 30 IF: 02 64 8 025 021880586. 60 FOODJRR 125 021900267. 60 IF:02-650 025 022808580. 50 FOODJFlR 125 02210 0386. 70 1R02651 025 022208596. 90 FOOD1JFlR 125 J-0367. 6Q 1R02652 25 822400597. 80 FOODJFlR 125 022580363. 40 1R02652 025 0226001574. 60 FOOD'JRF: 125 02270 8374. 50 1R2654 05 S . 228006G6. 10 FOODJRF; 125 02290 0369. 60 1R82655 025 . 23008575. 90 FOOD'JRR 125 022100378. 20 1R02656 025 02320 0599. 40. FOOD1JRR 125 023208377. 30 1R02657 025 022480573. SO FOOD'JRR 125 022580281. 20 1R02658 025 6122600511. 80 FOOD'JRR 125 82270 0296. 80 1R02659 025 023800611. 70 FOOD JRF; 125 0239610364. 60 1RI02660 025 024808594. 10 FOOD'JRF: 125 02410 8381. 20 1R03661 025 024208584. 70 FOODHRR 12S 02420 0266. 60 1R613662 025 82440 0420. 80 FOOD'JRR 13S 02458 8404. 60 1R02663 035 024600689. 50 FOODJRR 13S 02470 0371. 30 1R02664 025 024800492. 10 FOODJRR 135 02490 0394. 80 1R03665 02 S 02500 0517. 7Q FOODJRR 135 02510 8390. 80 1R02666 025 025208579. 70 FOODJRR 125 02520 0364. 70 1 2667 025 025480456. 20 FOOD'JRR 125 82558 0482. 60 1R03668 025 825608467. 10 FGODJRR 125 82570 0399. 20 1R0J668 025 025888599. 80 FOODJRR 135 0259610377. 10 1R02670 025 6126000613. 4? Fl IDD.TRR 1 " 5 ft 2 61 lift" : 71 4 0 12 l! 12 2 12 eZ 12 2 12 cZ 12 eZ 12 m 12 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 13 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 3 13 2 13 3 13 3 13 3 13 3 13 482. 7 292. 9 466. 4 392. 4 384. 1 421 5CiS. 7 287. 9 471. 9 285. 8 543. 2 388. 3 475. 8 375. 8 554. 7 372 501. 7 390. 2 515. 1 358. 7 675. 3 348. 3 586. 6 267. 6 508. 5 386. 7 596. 9 267. 6 597 363. 4 574. 6 374. 5 606. 1 369. 6 378. 2 599. 4 . 377. 2 573. 8 281. 2 511. 8 296. 8 611. 7 364. 6 594. 1 281. 2 584. 7 266. 6 428. 8 404. 6 689. 5 371. 2 492. 1 394. 8 517. 7 390. 8 579. 7 364. 7 BEST COPY AVAILABLE 456. 2 482. 6 467. 1 399. 2 599. e 377. 1 613. 4 371 4 593 GCC9S1 Oli 0 2620 8539. 80 FOODJAR 3_- 00 >0010202-. 8Q CC5 0 .`100580. 7*0 FOOD JAF: 12 0 7200374. 20 1R82672 13S 6. T'3-00528. 10 FOODJAR 2 5 0O ?4002S>4. 00 1' 1674 02-S . O''00622. 20 F.-_'DJAR 12 00 ?600274. 80 1R82675 03 O0 7700588. 70 FOODJAR 12 S . 0 7800371. 70 1R03676 00 7800651. 90 FOODJflR 13S 818800263. 80 1R03677 03 010108580. 80 FOODJAR 12 010200381. 40 1R0167S 05 01030 0550. 30 FOODJAR 13 01040 0395. 30 1R03679 02S 010508678. 70 FuODJAR 13 01 600239. 50 1RO1680 3 8 1878 8688. 50 F0 UDJhF: 3 01080359. 50 1R826S1 02S 01090561. 60 FOODJAR 13 011000368. 40 1R82632 03 011180463. 00 FOODJAR 12 011200401. 30 1R03682 02:5 01130 0642. 00 FOODJAR 12 811400344. 50 1R836S4 G2S . 11500640. 70 FOODJAR 12 011600353. 70 1R82685 02 011700532. 10 FOODJAR 12 011800384. 40 1R02686 . 119010590. 50 FOODJAR 12 612254. 5Q 1R03687 025 012100604. 00 FOODJAR 13 01220 0269. 30 1R03688 02*5 01230 0 5 9 4 . 00 FOODJAR 12 012400276. 70 1R03689 02 012500430. 30 FOODJAR 13 0112600393. 20 1R03698 02 012700564. 70 FOODJAR 13S 012808372. 10 1R03691 02S 8129O0488. 00 FOODJAR 12 S 013000391. 00 1R03692 03S 012180466. 20 FOODJAR 1 1 013280394. 40 1R03692 01S 013300654. 10 FOODJAR 12S 0 1240 0270. 30 1R02694 02S 013508575. 70 FOODJAR 12 S 013608366. 50 1R03695 02 012700620. 20 FOODJAR 13 01280 0259. 40 99 13 . 12 -i12 J j. 13 2 13 3 13 3 13 13 3 13 3 13 13 3 12 3 13 3 13 13 3 13 3 12 12 3 12 <; 13 3 13 3 13 j. 13 3 13 3 13 0 539. 8 383. S SSO. T J -74. .' 528. 1 294 623. 2 374. 8 598. 7 371. 7 651. 9 362 588 381. 4 550. 3 295. 3 679. 7 239. 5 680. 5 359. 5 561. 6 368. 4 462 401. 3 642 344. 5 648. 7 352. 7 533. 1 284. 4 590. 5 254. 5 684 369. 3 594 376. 7 430. 3 293. 2 564. 7 13 i ' cL. 488 291 466. 2 394. 4 654. 1 370. 3 575. 7 366. 5 628. 2 359. 4 BEST COPY AVAILABLE 594 C009S2 BISTCOPYAVAUABLE 1H O V E H k O RH L `.L*1E T > T O X -O N C - S T U O V O F FI-1-2 9 2 4 * F C - 1 4 3 IN R R T S EXP. * 0281CRO012 T E C H N IC IR N I N I T I A L S :S MH TO L'RV 5 L'H TE : 1 2 / 1 5 . '8 1 S E X OF. R R T 5 :S I1RLE KOOt'i N U I'lt E R . S D - 2 4 0 . D - 2 2 8 W EIG H T OF F U L L FO O D JH R : 5 5 5 0 G R 8 M S WEEK 24 1R:00516 03 L1007'_l0 0639. 8 Q FOOL-1JHP 115 00 72:00282. 20 1F:0i3 517 1'. 00 5 0015 5. 5 u FOODJHR 115 00V400279. 0 1R0O51S @1 o 500553. 70 FOOL 1HP. H i 0?600i297. 0 1R02519 v. 00 ?7`00592. 9Q FOOL' JHP l . o 0i - 8010i2 7`9. 10 1R005201 0x3 00 ?900533. 6Q FOOD JHR 1 1 S 010000391. 701 1R0O 5 s l OX- OlOlOOOiili*. ILL! FOOL-JHR 13 01 *J3003 53. SQ 1R0O522 01S F0 0 L' THP l l s 011014010287. 50! 1R02522 013 01000033-3. 5*0 FOODJHR: 113 0106083S3. 3-Q 1R62524 0115 011O7 0101575. 60 FOOL-JHR 115 010800274. 80 1R0G525 0115 011090101584. 4Q FOODJHR 115 011000279. 40 1R0O526 013 0111001033. 4Q FOOL1JHP I l l - 0110'0i284. 80 1RG2527 013 0113005*55. 2Q FOOL1JHR l l s - 0>li.40i0i290. 80 1R020SS 015 01150101880. 70 FOOL1JHR 115 011600269. 90 1R0O529 18 011170101598. 70 FOOL'JHR 115 011800292. 40 1 R0102 '0 015 119010542. 90 FOOL' JHR 115 012000392. 40 1R02531 013 011100533. 50 FOOD-JHR 115 0122001388. 60 1R03522 IS 012200591. 80 FOuC'JHR 15 012400383. 90 1R02533 015- 0112500608. 90 FOODJHR 115 012600384. SQ 1R03534 015 012700672. 40 FOODJHR 115 01280 0359. 80 1R03535 015 01129010532. 70 FOOC'JhR 115 01130010'279. 80 1R:02526 015 01131010496. 16 r `'OL1JHR: 115 012200418. 00 _ -*3*--0 S \ IS 0il220i0i504. 2 0 FOODJHR 115 013400298. 70 IP:I3-52S 013* 0x3500 3?6. 7*0 FuOC'J HP 115 1312.600262. 40 1R02529 013 013-700509. 70 FUODJHR 111 0 1 j-800387. 60 IF:03 040 615 013900538. 60 FOOL' JHR: 115 014000393. 30 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 6x9. 8 2- 8 2 . 3 590. 5 x-79. 1 563. 7 3-37. 2 592. 9 279. 1 593. 6 391. 7 529. 1 356. 8 567.3 387. 5 39. 9 3-S3. 3575. 6 374. 8 564. 4 279. 4 598. 4 284. 8 565. 2 296. 8 660. 7 369. 9 596. 7 392. 4 542. 9 392. 4 598. 5 288. 6 591. 8 283. 9 60S. 9 384. 8 6*t-' d 4 359. 8 532. 7 379. 8 496. 1 418 504. 3 298. 7 676. 7 263. 4 509. 7 387. 6 528. 6 393. 3 595 00983 IF'.'.. O'11 ' j l i I.u-l 1 0 0 * 0 0 40 FOOL-1j HF l i b Ui 4 _HtJ_ 71 70 IF'Oil 0 - 1 2 Jli- 014 80 F00[ 'JRF: 116 0 -t 'H.i0'2S4. 0 0 IF: 01 042 016 014 -00*80 1 0 FOUL1JHR 116 0x4 *0 0 1 1 * . 4 0 . IF U_ 044 O i l 014 r 0 0 *4 6 8 U j L'JRF 1 1 8 014 eOiuZOl. 0 Ci J r't-L 04 0 u l6 014 r"J0*19. r UL`L' 1HF 118 O i l >0003 71. s o . 1R 0_ 04 0 0 1 6 t ' l 0 1 lu*0 7 . 0 0 b 0 0 L1JhF: 116 J l'j 8 *. IQ ik o _ 047 u l 6 0 1 0 2 0100.71. 3*Q FOOL' .1HF: 116 0 1 0 400271. IQ 1 F02 048 0X6 0 1 0 '500669. 9Q FOOL' THF: 116 0 1 0 *003-67. 60 J>01 042 016 0 1 0 70014O. 9Q FOOL' JRF: 116 0 1 0 8003 97. 7Q 1R03 OOO 015 FOOL' JRF: U S 016 000404. 9Q 1P03 0 0 1 018 O i l 1001427. 2.0. FOODJRF: 116 016 201014x0. 6 Q iF:o_ 0 0 2 016 O i l 2-00652. 0 0 . FOOL' JRF: 115 016 40O318. 8 Q 1 R02 c~t~ 015 lj_l6 50O663-. 5Q FijOL1JRF: 115 0 1 * 6003-67. H-W xF 02- 004 O i l 0 J.6 n0457. IQ FOOL' JRF: 115 0 1 * 601014101. 9Q IF. 02 fc*crrr( 015 0 1 . .1 8 0 1 0 1 0 8 1 70 FOOL'JRF: 115 017 0003 83. 8 Q 1R:03- 006 015 017 1 0 1 0 1 6 6 1 . 40 FOOL' JRF: 115 1F:02 E;r-(-7 015 017 200275. 1 0 017 2010044. 60 FOOL' j HR: 115 0x7 4010140101. 60 1.P03 (Tc-,V 015 017 500503. 6 0 . FOOL' JRF: 115 017 *0 0 3 88. 6 0 . 1F-02-ir SC* 015 017 7 00560. 2 0 . FOOD .'HR 115 017 80C*3 91. 40 1F02 060 015 017 96043 9. IQ FOOL' JRF: 115 6 1 8 000506. 3Q O i l R 0 2 OIS 016 1 0 0 1 6 8 1 . 70 FOOL' JRF: 115 018 200252. 1 0 IRC12 062 015 0 1 S2010014. 80 FOODJRF: 115 018 40101267. 1 0 IF '02 062 015 016 060018. 1 0 FOOL1JRF: 118 0 lS 600266. 1 0 xPU2 064 018 016 700072. 3-Q FOOL'JRF: 115 016 6001272. 0 0 1F:02 065 015 018 900640. 40 FOOL' JRF: 118 018000271. 1 0 IF '02 566 018 0181001486. 70 FOODJRF: 118 018 100410. IQ IF'02 567 018 018 300687. 2 0 FOODJRF: 118 0118400564. 50! 1F:02 56S 018 018 000626. 2 0 FOOL' JRF: 118 018600262. 0 0 . IF: 02 018 O I S O0667. 70 FOOL' JRF 115 018 6002-57. 2 0 0 2 576 018 118800508. 60 t .jOL' JRF 115 0 '2 0 0 1 0 1 015 101. 40 IF: 02 071 618 O l'O1 0 1 0 1 6 2 0 1 9Q FOOL' JRF 1 1 6 * 100369. 0 0 i r,03 072 015 03`U200574. so FOOL' j HR: 115 0 1 0 40101260. 60 IF:02 072 0 x5 010 -001627. 0Q FOOL*JRF 118 0i2 60*0127 1 . 70 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 BEST COPY AVAHM 60 4 271. 1* 90 6 S . 264 680. 1 3:3'6. 4 648. 8 201 618. 6 J- I-' 3. 8 607 3;8`6. 2 671. 5 271. 2 669. 9 367. 6 040. 8 287. I*- 524. 404. 8C| 427. V 410. 6 652. 5 228. 8 663. Cj 367. 4 457. z* 410. 9 581. 7 282. 8 661. 4 275. 1 544. 6 4010. 6 .0 0 2 6 6 560. 2 393. 4 428. 31 506. 3 691. i*' 252. i 514. 8 287. 1 518. 1 286. 1 57 3. 2 272 640. 4 371. 1 486. l'' 410. 2 687. 2 364. 5 638. 2 362 667. 7 257. 2 558. 6 310. 4 630. 9 268 074. 8 385. 6 637 271. ? 596 0009S4 J k >.'_ 57 `1 U_ U1 L10 2 2 0 FOOL'J H r 1 1 -. y 0 u o u 0 2 x x 4'.' iF 'H . 0 , 3 L12 U_ *Jr*0 0 0 2 4 lj l j t-uOD JRF H i U L iiJ U it'j. 4 0 1RO I S . 8 0 1 3 U l l i UU 5 4 6. 6`0 FuuL'JRR l 0 x 1 1 0 0 2 9 1 . 80 '0 1 5 7 7 0 2 2 *J_:22 0 0 0 6 0 . 5 0 ..OL1J h R 1 2 0 x 1 4 0 0 3 7 3 . 6 0 j. PGC l_<,>: 0l -. I . i x l ' '0 0 3 l'iH 4 0 FOODJRF 222. -0 6 l*U j> 5 .8 . 0 1 R 0 Z 5 7 ;* 0 2 . 0 2 2 >o 0 6 6. ? 0 F OOL'JRR 1 1 3 U xx8 0 O 2 63. 2 Q l R y x 58L> 0 1 3 0 x 1 9 0 .0 5 4 4 . 1 0 FOOL1JRR 1 1 3 0 2 2 0 0 0 2 7 7 . 2Q IF : j 5 8 1 01X3 010' :`X 0 0 5 9 6 . 7 0 FOOL'Jh R 1 x S 0O Vx 010 3 7 5 . 2 0 1 R 0 2 58 2 02S 00 ;2 0422. 10 FOOL'JRF: 1 2 3 00 P 4 0 0 2 9 4 . 5 0 1 F :0 3 5 8 2 02S 00?" 0447. 0 FOODJ HR 2 2 6 0 O >6 0 O2-8 2. 4 0 1 R 0 2 5 8 4 0 2 6 OO > 7 0 0 4 8 2 . 4 0 FOuD JRF: 2 2 S 0 0 ? 8 8 2 8 i. 5 0 1 R 0 2 5 8 5 0 2 3 0 0 ?9 01G5 2 3 . 0 FOOL* JRF: 1 2 3 0 X 000I 373. 0 0 F:02 5 8 6 0 2 6 0 2 0 2 0 0 0 4 6 . 7 0 FOOL'Jh R 2 2 5 0J.O 2O 0276. 7 0 1R 0356? 026 O202OO448. 50 FOODJRF 1 2 3 0 1 4 0 0 4 0 9 . 0 1R02588 023 01050515. 20 FOOL'Jh R 1 2 3 0 1 0 6 0 0 3 8 5 . 4 0 1R02588 623 010700492. 10 FOODJFiR 1 2 3 0 1 0 8 0 0 3 7 1 . 0 0 1 R 0 3 5 9 0 0 2 S 0 x 6 0 OOO0. 0 0 RRT # 2 R 5 !r*O 02s FOOD JRF: 123' 011101000100. 00 1R02591 023 o iil0 0 3 9 9 . 60 FOOL1JRF: 2 2 8 0 2 2 2 O O4 O0. 20 1R62592 0X3 011300572. 20 FOOL' Jh R 1 x 3 01140101376. 6 0 1 R 0 3 5 9 3 0' 2 3 ii5 i0 4 9 2 . 0 0 FOOL'Jh R 1 2 3 0 1 x 6 0 0 3 7 8 . 2 0 IF :0 2 5 9 ' 1 0123 0 x 1 7 8 0 5 5 6 . 6 0 FOOL'JhR 1 2 3 0118001367. 4 0 1R 02593 023 011904601. 70 FOOD JRF: 2 2 8 0 2 2 0 0 685*. 4 0 1R03596 023 012100601. 00 FOOD JRF: 1 2 3 1R02597 023 FOODJRR 1 2 3 0 1 2 4 0 0 4 0 7 . 9 0 1R02598 023 012500526. 40 FOODJRR. 1 2 3 0 1 2 6 0 0 2 7 8 . 6 0 1R03599 023 012700504. 60 FOODJRR 1 2S 0 1 2 8 0 0 2 8 0 . 0 0 IF : OS6 00 0 2 S 0 1 2 9 0 0 5 1 9 . 6 0 FOODJRR 1 2 3 0 1 2 0 0 0 2 7 1 . 1 0 1 R O 2 6 0 1 023' 0 1 2 .1 0 0 5 5 2 . 00! FOOL1JRF: 1 2 3 0 1 2 2 0 0 2 7 7 . 6 0 ' " `G 2 6 0 2 0 x 3 0 1 2 2 0 0 5 2 2 . 8 0 . OL'JRR 1 2 3 0 1 2 4 0 0 2 6 7 . 4 0 i F`0 2 6 O3 0 2 3 0 1 2 5 0 0 5 4 2 . 7 0 FOOL* JRR 1 2 3 0 1 2 6 0 0 2 8 4 . 2 0 J.R 0 2 6 0 4 0 2 3 0 1 2 7 0 0 4 9 6 . 00! FOODJRR 1 2 3 0 1 2 8 6 0 3 9 0 . s o 1 R 02605 023: 0129001488. 00 FOOL' JRR 1 2 3 1 1 4 0 0 0 2 8 4 . 0 0 J.F'0260 0 2 3 0 1 4 1 0 0 4 4 0 . 4 0 1 11 1 11 1 11 1 11 1 11 1 11 1 11 6* 12 12 2: 12 d! 12 12 d 12 2 12 Cm 12 2 12 d 010900000. 00 12 d 2 12 12 2 12 12 Cm. 12 d' 12 d 12 cL 12 d! 12 > 12 2 12 Cm 12 d` 12 12 2 523. 8 221. 4 524. 5 265. 4 546. 2 291. 8 580. 5 275. 9 559. 4 258. 8 588. 7 268. 2 5 4 4 .1 Ji- < V. ei 586. 7 275. 2 421. 1 394. 5 4-4 tf' . Cm 282. 4 481. 4 291. 5 522. 1 " '7*<'. 548. 7 278. 7 448. 5 409 515. 2 285. 4 492. 1 271 0 NOT ON s t u d y 0 288. 6 400. 2 . 572. 2 276. 2 492 278. 2 556. 6 367. 4 460. 7 289. 4 601 3 6 3 .7 4 7 8 .6 407. 9 526. 4 378. 6 504. 6 280 519. 6 371. 1 552 277. 6 532. 8 367. 4 b e s t COPY AVAILABLE 542. 7 384. 2 496 290. 8 48 384 440. 4 597 C009S5 BEST COPY AVM ABLE F'juL hf a - - .l` l2Jti418. 0:'-' 12 i ROOFO' I L`l 4 - U0L:*u l. 10 X FOOL JHF: 122 01440047. 10 12 IF:'.'!; F.08 022 _'45`j0 5 6 o . 40 2 FOOL JRF 122 01 4*100 2 58. 10 1F:G>3 014 7u 0 0u. 7u 12 2 FOOl JHF: 122 j 14 8 u 0 1 75. 4L' 12 _i3 610 r .li- >jj.4 200552. 0 2 FOi' i 2Hr- 122 j1 '50 *j 0 2 1-5. 50 12 1P03 F ix `-1X 015 x O054 5. 00 2 FOOL JhF I f- 2 0x5200 265. >30 12 IRC13 0X2 02S u 152 0 0i525. 10 2 FOOL JHF x26 01154 0101282. 70 i R0>36x3 022 0iX55 00i616. 2 12 2 FOijL J FiF: 122 01x 5 6 0i012-8 5. 80 12 IF ' 02 014 022 0157'0101456. 50 2 FOOL JHR 122 0 x 5 8 010175. 10 12 1R03 0x0 022 01550101455. 40 FOOL JHR 122 0116.0100ij: 73:. 00 2 12 1R03 610 22- .6>1610i0i528. 00 d FOOL J FtF: 122 t i l 6 2 0 0i2 75<. 20 12 I F 02 OIF 02S 0116"2-00512. 00 d FOOL JHF 122 0x04 0 0 2 8 -'. 40 12 F:03 01.i 0i2 2 0116-0i0 0 6 0i8. 50 2 FOOL. J FtF1 122 0i1 6 6 0i 2 65. 80 12 1R03 OIF 022 0i16-7'0i01462. 80 d FOOL JhF: 122 0ix 6 6 0i02 82. 90! 12 IF. 03 020 022 0i168 05401. 40! 2 FOOL J hF: 122 0117010i0i2 68. 20 12 IF: 02 021 025 Ox FX04 28. 0:0 2 FOOL J hF 122 Ox7'20407. 60! 12 1036 22 0i22 i'x 7 x 0 0 4 4 . 7'0 d FOOL JHR 122 0174010392. 80 12 F:02 5H 022 3X7000512. 80 d FOOL JHF: 122 &1780372. 70! 12 IF: 02 024 02z- ix 770O5 5 9. 70 2 FOOL JHF: 122 017800268. 00 12 IF: 02 F.2-' 025 0 1 7 9 0 0 0 0 O. 10 2 RFlT # 1R02625 0120". O179O00O10. 10 FOOL JHR 122 >310:>30 >300O. >30 12 1R03 0-20 022 0181 >30544. 00 2 FOOL JHR 122 0 x8200 2 801. 70 12 1R02 022 016200525. 60 2 FOOL ,TRR 122 >310:400292. 60 12 1R02 528 022 018500510. 00! 2 FOOL JhR 122 010:0.00292. 20 12 J.R02 628 022 >318700571. 00! FOOL JhR 122 016:O:>I102:?0. 10 12 1R.02 620 022 010:9001457. 40! d FOOL JhR 122 0190100298. 10 12 1R02 621 022 019100502. 10 2 FOOL JHR 12S 0192O274. 80 12 R02 622 025 019200506. 10 d FOOL JHR 1CV 1 01940020:5. 50 12 1R03 622 G22 01950 0587. 00 2 FOOL JHR 122 01900020:2. 00 12 1R03 624 022 0197'O1406. 50 2 FOOL JHR 122 0x90:0020:0:. 10 12 02 62 5 022 0199G0447. OQ 1 i- j OL JhR 122 Oi2Gi0100400. 10! 12 IF '02 6 022 020100544. 80 2 F OOL JHR 122 02020.10280. 20 12 xF'0i2 62? 022 0202010524. 20 2 FOOL JHR 122 2040267. 00 12 1F:02 6 ! 8 022 UXO50O4 9>3, 90 2 FOOL JHR: 1 2 2 0206 0 0 2 8 9 . 2 0 12 418. 501. 1 407. 1 588. 4 e.1; 1 58ti. ' ~7 '*> 4 592. 369. der 545 3-09 529. i x-82. i* 010. 3:85. 490. 8er 3:75. i 495. 4 ~77 529 275. 3 513. 6 y .cr 4 609. 5 265. S 462. 8 7.8*: ) 540. 4 7.88. 3 438. 8 407. 6 442. 7 292. 6 512. "1 273.. 559. i 200:. 6 . O. 1 NOT ON O 544. 6 3 90. r" 525. 6 292. 6 510. 6 392. y 571. 6 370. i 457. 4 298. 1 502. 1 274. H 5016. i 385. CSj 587. 6 383. 6 400. ej 288. l 447 40>6. 2 544. 6 380. X- 524. 207. 6 496. 9 389. C- 598 000936 i ko_ 6 : - Jk. n k'Mi ij0484 X`|J FmmL'JhR XXx uX^r-UUX X_ L*.` I m .v 6'lH OwX ux0r*00X X7. X0 FOOL' JHK 122 O'iLXui-i04 X9. 60 i KU_ t-4 J. o x s 02X1tt0 t6 . 5M FOOL'JhK 122 0x i. x u 0 X-8 6. so 92642 OXS 0 x ix tt4 7 4 00 i ..'OL'JmK x_X 021400298. 00 lF tC e -*!! 0 X mXx X*0 0 X4X. 41.7 Pmi.iL' JHK 122 UXXC-tfOX 84. 20 J.R.t..: 6 4 'i uX'.x- o 21? tt492. XC FOOL' Jl-iK 12^. 0 Xx XKJ0 X8X. X-L! 1R62645 OXS 0xx8*u O56 X-. 70 FOOL' JHK 122 OXX0 0 0 X'X7 . 80! 1R03646 ox s 02x100011. 00 FOOL'JhK 12 2 022200287. 40 IF: 02 6 `17 OI-S 2 2 2 0 502. 26 FOOL'JHK 122 0 2 2 4 0 O408. 70 1F:012648 022 022500684. 2Q FGODJHR: 122 6 2 260 0 X-X16 . 56 1R03649 OX'S 0122700587. 8Q FOOC'JHR. 122 02280*3260. 76 1R0136501 OX6 t 2 2 9 w 5 1 *3. 1Q FOOL'JHK 122 0 2 X0 0 0 2 9 0 . 60! 1K02F01 OX3 021100601. X- FOOL1JHK 122 0 2 X200269. 96 1R.02652 OXs 0 2 2 X0O6O2. 80 FOOD JFiR 12 2 022400277. 00 1R03653 oxs 022500582. 26 FOOL1JRR 122 02X6O0X.72. 76 xK>-'2 -04 OXS 022700615. 70 F'JhF' 12 2 022 800264. 50! 1R02655 0X5 02X 900585. 26 FOOL1JHR 12 S 02401010275. 16 iR 0i2656 OX s 02410059?. 40 FOUL* JRP 122 024 200281. 60 1R.0265'7 o x s 024100579. 90 FOOL'JHK 122 024400287. 76 1R02656 OX-5 024500524. 16 FOuL1JrtR 122 024600401. 20! Xr 0 X6 5 5* 0 Xs 024 7Q0620. 16 FOOL* JHR 122 O24800266. 20 iLFlOx 660 o x s 01249010597. 86 FOOL'JHK IX s 025000285. 56 J.RX 66J. 0X-S 0125100594. 96. FOOL'JHK 1XS 025208272. 66 1F:02662 o x s 025300142?. 26 FOOD'JRF: 122 012540104019. 20 1R03663 022 025500615. 56 FOOL1J HR 122 025600278. 06 IF:02.664 X-S 025700490. 9G-! FOOC'JHF: 122 025800401. 20 1R013665 035 0125900512. 86 FOOL'JHK 122 026000298. 26 1R.02666 022 FOOL'JHK 122 0i@'7100370. 66 ` ~OX-667 ox s 010' 72004519. 56 , ..OL'JHK 122 00 7200X97. 16 1R03668 OXS 00i 7400468. 20 FOOL'JHK 122 007500407. 86 1R02669 OXS' 00 7600608. 00 FOOL'JHK: 122 0O V700X7X-. 56 1RO2670 OX s tt 78010'618. 10! FOOC'JHF: 12 2 00 7900268. 86 1R0267'1 OXS t 10i010i0543. 00 X' 12 X 12 12 X 12 x 12 X 12 X 12 X12 X 12 X13 2 12 x 12 X- 12 X- 12 x 13 x> * 12 13 X12 x 12 X12 x. 12 x 13 X 13 X12 X13 12 X- 12 *<. 12 x 13 13 ", 12 x 12 X- 484 2 BESTCOPYAVAABLE 3 9 .3 419. 6 5t6. 5 286. 8 474 TXC 542 4 284. X 492. X X8X. 2 562. 7 267. 8 511 X87. 4 502. 2 488. 7 684. 2 356. 5 587. 8 360. 7 510. 1 290. 6 601. 2 X89. 9 602. 8 " 77 583. 2 Xv' 2. 615. 7 264. 5 585. 2 275. 1 597. 4 281. 6 579. 9 287. 7 524. 1 401. 2 620. 1 266. X597. 8 385. 5 594. 9 272. 6 427. 2 409. X 615. 5 Z'78 490. 9 401. 3 512. 8 298. 2 586.8 270. 6 459. 5 397. 1 468. 2 407. 8 608 272. 5 618. 1 268. 8 542 599 G009S7 BEST COPY AVAU ABLE F ' ".'L1Jh F x_ 2 UXUJ. 0 L'2 8 0 4*7 ir g : t l'2 8 n i yoi_i0S0 v ; 2*-! F O u [1Jh F' 1 . - 010_; 0 0 2 7 ?. 7 0 XK02 672- 0_ f. 0 1 'J 4 0 0 24 0. 4L! F OuL' j HF. i : s rij. h 3 0 0 2-8 2!. 2 Q IF . 00 6 7 4 02 0 1 0 6 108 2 1 . 2 0 FOOL'JRR 1 0 5 0 1 0 7 0 0 3 6 8 . 2*7 02 6 7 5 812S O IO S 0 0 6 0 4 . 3 0 i- .JOL-' JRR 1 0 5 0 1 0 9 0 0 3 5 5 . 0 0 1R03676 03 S 611000650. 88 FOOL'JRR j_8S 111O 0O 59. 2 0 1 R 03671' 02 3 0 1 1 3 0 0 5 S4. 6Q FOOL' JRR 2 3 0 1 1 0 -0 0 3 8 0 . 7 8 1 R 0 3 6 7 8 02 S 0 X 1 4 0 0 5 5 5 . SO FOOL' J h F: 1 0 5 O 1 150O 29X . 8C* xR*73 678 0 2 2' 011 8 0 0 8 88. S FOOL1JmR 12S 01170034O-. 2-Q 1R036S0 02 3 0 x 1 5 0 0 8 0 7 . 10 FOOL1J hF: 105 011900365. 50 xF:03.68x 02 S 0 X3 0 0 0 5 6 x . 50 FOOL'JHF: 105 0131003-80. 20 1R03682 0 2S' FOOC'JHR 105 0130-00409. 20 1 ROJOS3 02 8 01340 0647. 8Q FOOL1JHF: 105 013500347. &Q 1R02684 02 8 0126 0016 2-8 . 40 FOOL'JHF: 10 5 0137 O0-6 O. 8Q 1R03685 02 S 01280 0533. 20 FOOL'JHF. 105 012900385. 0Q x Rl*_'6o6 02 S 0 x3000 597. 5Q FOOC'JHR 105 0 x3100 272. 10 1R026S7 0 2S 01220 0617. 2Q FOOC'JHR 105 01X2-2010276. 80 1 Ru_688 02 S 010-400596. 80 FOODJHR 105 010500085. 80 1R02-688 0 2 2 0112-6 0i42-5. 90 FOOL'JHF. x3S 013700393. 20 R03 690 0i2 5 012800568. 70 FOOC'JHR 105 013900072. 20 1R02691 02 5 014000488. 10 FOOC'JHR 105 1410392. 30 1R02692 60S 014200474. 40 FOOC'JHR 12S 0140-00399. 20 1R02693 005 014400661. 90 FOOC'JHR 135 014500367. 50 1R:03 694 2 S 014600572. 20 FOOC'JHR 105 1478366. 20 1R03 690 OS 014800625. 80 FOOC'JHR 105 0149000-60. 2Q C r ljC tC iQ * -i'-J *4'4 10 12 J. 13 12 J. 12 jj. 13 13 J. 13 12 s 13 13 * 13 3 13 13 12 13 jj. 12 13 2 13 3 13 3. 12 13 " 13 J 13 13 0 _4 587. 2 777 7 540. 4 2-8 2. 2 621. 2 268. 3 604. 2 255 650. 9 359. 2 584. 6 280. 7 555. 5 381. 8 688. 6* 342. 2 607. 1 365*. 5* 561. 5 280. 2 4 6 5 .9 409. 2 647. 8 347. 6 638. 4 2 6. 8 5 2-3. 2 .0 85 5*87. 5 372. 1 617. 2 376. 8 596. 8 385. 8 435. 9 283. 2 56 8. 7 *? " 488. 1 2-82. 3 474.4 388. 2 661. 9 267. 5 572. 3 366. 2 625. 8 360. 3 600 0009S8