Document xdLvGZG45DzNRGr11238G8yyb

Nay 16, 1903 TOXICITY AND SUS HANDhlNO OF TXmAVu IbO The animal toxicity report on Pydraul 150 indicates that It Is practically innocuous whan fad orally to rats sines the animals aurvivad single dosas of 86.5 grama par kilogram with loao of appatita and savara diarrhea as the only fcaxle offsets. The fluid apparently is not absorbed through the unbroken akin of rabbits since this species survived dosas up to 9.5 grams par kilogram of body weight. In rabbit skin and aye irritation studies, Pydraul 150 was no more irritating than a 10 par cent aoap solution tested simi larly. In oases whore workmen have aooidentally splashed or rubbed Pydraul 150 into the eyas, thsre has bean severe pain out of proportion to the degree of irritation. This is similar to the situation with most synthetic fluids as wall as with many light petroleum oils. Physiciano have used a 0.5 per eant pantocaine solution and ophthalmic cortisone acetate solution to relieve irritation. In acute vapor inhalation studies, rats survived a six-hour exposure to an atmosphere saturated with Pydraul 1&0 vapors at room temperature. Based on the animal toxicity data and handling experience, our label includes the following precautionary information! CAUTION: CONTAINS CHL0RINATJ5D HYDROCARBONS Avoid prolonged breathing of vapors or mists. Avoid eontaot with eyes or prolonged contact with skin. - If akin contact occurs, remove by washing with soap and water. Following eye contact, flush with water. If clothing becomes soaked with fluid, launder before wearing again. R. Emmet Kelly, M. 0. Medical Director The materiel is thia report is to be ueed in development o( the product end may be given to reeponaibte aalee contact*, but it ia not to be ueed by them in edvertieing copy. The source of thie meterial it not to he divulged until it eppeera in formal publications. No axoaptiona to tha established.rule may be mede without the epproval of the Mediae! Departmeet in 8L Louie. Customer*' inquiries regarding matters of toxicity are to be referred at before to the Medical Depart ment in St. Louis for reply. -- Monsanto Chemit-ai Company . MONS 071170