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fL vi n . t7 u j CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE, POLYVINYL CHLORIDE AND STRUCTURAL ANALOGUES tc C- l -{ W*. ,-iO-VWV. Uu_ L^v,j . juW^? ^ taarc* 20-21, 1980 . U- jvvC..4. v'i-. e :v* <v i\*j Pt'c cLa-U . rj <v U ,? tit- # fab 1 -rv* ,x^'vvr^. ^ /^i ,-uir .'\L zt ^ .7,^ titUtt-jl . r Cm *-y* \n. -- .* ^ vt, u jvv-. <,~j ^ u National Institutes of Health "= Masur Auditorium jus'j*<i Building 10 ;LU. ,, ^ / Cw 1. ill L<. T Clinical Center Bethesda, Maryland ^ iv*v i<. 17 , .^4* 4 "-t, t''1 V ^ - .<-. j URL 01038 Cosponsors National Institutes of Environmental Health Sciences National Institute for Occupational Safety and Health Occupational Safety and Health Administration Thursday, March 20, 1980 . . . . . --------- ------- - . - - - --------...................................: -------- ------------- ----------- 8:00 A.M. REGISTRATION 8:30 A.M. INTRODUCTORY REMARKS Dr. David Rail, NIEHS SESSION I -- CARCINOGENESIS BIOASSAYS OF VINYL CHLORIDE MONOMER * Chairperson: Dr. Umberto Saffiotti, NCI 8:45 A.M. 1. Carcinogenesis Bioassay of Vinyl Chloride Monomer with Particular Reference to Multiple Sites and Dosage Review Dr. Caesar Maltoni, Institute of Oncology and Tumor Center, Bologna 9:45 A.M. `2. Experimentally Induced Pulmonary Cancer Dr. Y. Suzuki, Mt. Sinai Medical School 10:00 A.M. Discussion g 10:15 A.M. 10:45 A.M. Break 3. The Role of Aging on Vinyl Chloride Monomer - Induced Cancer Dr. David Groth, NIOSH 4o20 ^ 11:00 A.M. 4. Carcinogenic Effects of Exposure to Vinyl Chloride Monomer and Ethyl Alcohol on Rats Dr. Martha Radike, University of Cincinnati 11:15 A.M. 5. Cancer Induction Following Single and Multiple Exposures to a Constant Amount of Vinyl Chloride Monomer Dr. Robert Hehir, CPSC SESSION II - TOXICOLOGY STUDIES OF POLYVINYL CHLORIDE ChairDerson: Dr. Peter Infante, OSHA 11:30 A.M. 6. Pneumoconiosis in Animals Exposed to Polyvinyl Chloride Dust Dr. David Groth, NIOSH 11:45 A.M. 7. Results of Carcinogenesis Bioassay of Polyvinyl Chloride . Dr. Chris Wagner, BMRC, Penarth, Wales Thursday, March 20, 1980 URL 01090 SESSION III-SPUTUM CYTOLOGY OF VINYL CHLORIDE WORKERS Chairperson: Dr. Peter Infante, OSHA 12:00 P.M. 8. Results of Sputum Cytology Among Vinyl Chloride Polymerization and Polyvinyl Chloride Fabrication Workers Dr. Caesar Maltoni, Institute of Oncology and Tumor Center, Bologna 12:15 P.M. Discussion 12:30 P.M. LUNCH SESSION IV-MORTALITY STUDIES OF WORKERS EXPOSED TO VINYL CHLORIDE Chairperson: Dr. Philip Landrigan, NIOSH 2:00 P.M. 9. Multiple Site Risk Analysis of Vinyl Chloride Related Cancer in Workers - Review Dr. Peter Infante, OSHA 2:15 P.M. 10. Cohort Mortality Study of Vinyl Chloride Workers Dr. H. Weber, Der Staatliche Geverhearzt, Fed. Deutch Republic 2:30 P.M. 11. Epidemiological Study of Vinyl Chloride Workers Dr. Clark Cooper, Consultant 2:45 P.M. 12. Power Considerations in Epidemiologic Studies of Vinyl Chloride Workers Dr. Jay Beaumont, NIOSH 3:00 P.M. Discussion 3:15 P.M. Break SESSION V - LIVER AND BIOCHEMICAL CHANGES ASSOCIATED WITH VINYL CHLORIDE Chairperson: Dr. David Groth, NIOSH 3:45 P.M. 13. Epidemiologic Review of Hepatic Angiosarcoma in the United States Dr. Henry Falk, CDC Thursday, March 20, 1980 4:00 P M. 14. United Kingdom Angiosarcoma Registry Dr. Peter Baxter, CDC 4:15 P M. 15. Pathology of Vinyl Chloride Induced Liver Lesions Dr. Hans Popper, Mt. Sinai Medical School 4:30 . P M. 16. Liver Screening Tests for Vinyl Chloride Exposed Workers Dr. Carlo Tambero, University of Louisville SESSION VI - INDUSTRIAL HYGIENE MEASUREMENTS OF POLYVINYL CHLORIDE OPERATIONS Chairperson: Mr. James Gideon, NIOSH 4:45 P M. 17. Polyvinyl Chloride Processes and Products Dr. R. Nick Wheeler, Union Carbide 5:00 P M. 18. Characterization of Polyvinyl Chloride Homopolymers, Copolymers and- Additives Mr. Jay Jones, NIOSH 5:15 P M. Discussion URL 01091 Friday, March 21, 1980 URL 01092 SESSION VII - MORBIDITY AND MORTALITY STUDIES OF POLYVINYL CHLORIDE EXPOSED WORKERS / . / 8:30 \/ A.M. Chairperson: Dr. R. Greenberg, University of Louisville 19. Mortality Among Polyvinyl Chloride .Fabricators Dr. Leonard Chiazze, Georgetown University 8:45 A.M. 20. Heart Disease in the Swedish Polyvinyl Chloride Fabricating Industry Dr. Gustavo Molina, Colombia 9:00 A.M. -21. An Epidemiological Study of Respiratory Disease in United Kingdom Workers Exposed to Polyvinyl Chloride Dust Dr. Anthony Seaton, University of Edinberg 9:15 A.M. 22. Polyvinyl Chloride Dust Induced Pneumoconiosis Dr. A. Arnaud, Marseille, France 9:30 A.M. 23. An Epidemiologic Study of Pneumoconiosis in the Italian Polyvinyl Chloride Industry Dr. Guiseppe Mastrangelo, Padova, Italy 9:45 A.M. 24. A Case-Control Study of Lung Cancer Among Vinyl Chloride-Polyvinyl Chloride Workers Dr. Richard Waxweiler, NIOSH 10:00 A.M.- 25. Review of Pulmonary Effects of Polyvinyl Chloride Exposure Dr. Ruth Lilis, Mt. Sinai Medical School 10:15 A.M. Discussion 10:30 A.M. Break Friday, March 21, 1980 URL 01093 SESSION VIII - REPRODUCTIVE EFFECTS OF VINYL CHLORIDE Chairperson: Dr. James Wilson, University of Cincinnati 11:00 A.M. 26. Transplacental Teratogenic Effects of Vinyl Chloride in Experimental Animals Dr. Jackie John, DOW Midland 11:15 A.M. 27. Transplacental Carcinogenic Effects Dr. Jerry Rice, NCI 11:30 A.M. 28. Mutagenic Effects of vinyl Chloride Dr. Jill Fabricant, University of Texas, Galveston 11:45 A.M. 29. Power Considerations in Studies- of Reproductive Effects Associated with Vinyl Chloride and Some Structural Analogues ^ Ms. Maureen Hatch, Columbia University 12:00 P.M. Discussion 12:30 P.M. LUNCH SESSION IX - ENVIRONMENTAL EXPOSURE TO VINYL CHLORIDEPOLYVINYL CHLORIDE AND LIVER ANGIOSARCOMA Chairperson: Dr. Pier Bertazzi, Institute of Occupational Health, Milan 2:00 P.M. 30. Fugitive Emissions of Vinyl Chloride-- " Polyvinyl Chloride Speaker to be Announced 2:15 P.M. 31. Case-Control Study of Liver Angiosarcoma Among Residents in New York Dr. Nicholas Vianna, N.Y.S. Department of Health Friday, March 21, 1980 SESSION X - CARCINOGENICITY OF SOME STRUCTURAL ANALOGUES OF VINYL CHLORIDE Chairperson: Dr, Kim Hooper, University of California, Berkeley 2:30 P.M. 32. Comparative Pathology of Vinyl Chloride and Vinyl Bromide Induced Liver Pathology in Animals Dr. William Busey, Experimental Pathology Laboratories 2:45 3:00 3:15 P.M. P.M* P.M. 33. Review of Experimental Carcinogenesis of Vinyl Chloride Related Compounds Dr. Ken Chu, NCI 34. Review of Epidemiologic Study Results of Vinyl Chloride Related Compounds Ms. Rosanne Apfeldorf, OSHA Discussion 3:30 P.M. Break SESSION XI - RESEARCH NEEDS AND PUBLIC HEALTH INTERVENTION Chairperson: Dr. Anthony Robbins, NIOSH Panel Discussion: 4:00 P.M. 35. Dr. DaleHaddis, Center for Policy Alternatives, MIT 4:15 P.M. 36. Mr. Steve Wodka, OCAW 4:30 P.M. 37. Dr. Maurice Johnson, B.F. Goodrich 4:45 P.M. 38. Dr. Irving Selikoff,. Mt. Sinai Medical School 5:00 P.M. 39. Dr. Joseph Wagoner, EDF 5:15 P.M* Discussion Proceedings from the Conference will be published. URL 01094 4 Program Planning Committee Dr. Richard B. Everson NIEHS, Research Triangle Pa^k, North Carolina Dr. Peter F- Infante OSHA, Washington, D.C. Dr. Philip J. Landrigan NIOSH, Cincinnati, Ohio Dr. Raymond E. Shapiro NIEHS, Research Triangle Park, North Carolina Dr. Richard J. Waxweiler NIOSH, Cincinnati, Ohio URL 01095 r m w*; i ^ ^i ^ i r r i !=i ;' v<= ; ;;! i 960V O W . , . t;-:Tn*r:rTrrHTrri c.n'>a.*u L-*AKv*'---.i' j U'u.i u1J w$\