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Rachel's HAZARDOUS WASTE NEWS #171 Providing news and resources to the Movement tor Environmental Justice - March 7,1990 Dioxin-Part 1 DIOXINS AND CANCER: FRAUDULENT STUDIES For years, industry scientists have been claiming there's no evidence that dioxins cause cancer in humans. Now there is mounting evidence that such claims reiy heavily on studies thatare fraudulent Two companies recently accused of producing fraudulent dioxin-and-health data are Monsanto and BASF. Uonsanto A scientist with U.S. Environmental Protection Agency (EPA) says Monsanto falsified data in im portant studies that Monsanto used to support its claim that dioxin does not cause cancer in humans. Dr. Cate Jenkins, a chemist in EPA's Office of Solid Waste and Emergency Response, says EPA itself re lied upon Monsanto's fraudulent data in setting health standards for dioxin, and Jenkins has asked the EPA's Science Advisory Board to reopen the matter of EPA's dioxin standards, to take a fresh look at available data.1 Two important sources of dioxins in the environ ment are old chemical dumps and the incineration of municipal solid wastes,2 which is why EPA is con cerned about allowable levels of human exposures to dioxin. BASF The British technical journal. New Scientist, says, "A new analysis by a West German epidemiologist may have established the first dearcut evidence of a direct link between exposure to dioxins and cancer in humans. Friedemann Rohleder, an independent specialist, has produced a report detailing an unexpec tedly high incidence of cancer among workers exposed to dioxins during an industrial actident at a chemicals plant in 1951s The plant, operated by the West German com pany BASF, made trichlorophenol. Rohleder claims file company presented the data in a way that dis guised the cancers," says New Scientist Background Each of these claims of fraud relates to an in dustrial accident in which workers were exposed to dioxins; follow-up medical studies funded by the responsible companies have been published in main stream scientific journals, claiming to show that no excess cancers have occurred in the dioxin-exposed ' workers. In fact, excess cancers have occurred, but it appears that the data have been manipulated to hide the facts. The Monsanto Case In 1949, an explosion occurred at a Monsanto chemical factory in Nitro, West Virginia: as a result, many workers in the plant were exposed to the herbicide 2,4,5-T, which was contaminated with dioxin. (This herbicide was later the principal component of Agent Orange, the chemical defoliantused by the U.S. in Viet Nam.) In subsequent years, two Monsanto scientists, J A Zack and R. W. Gaffay, studied the exposed workers, comparing their health against the health of a similar group of workers who were not exposed to dioxin or 2,4,5-T.4 According to court documents attached to the EPA memo,"Zack and Gaffey deliberately and knowingly omitted 5 deaths from the exposed group and took four workers who had been exposed and put these workers in the unexposed group, serving, of course, to decrease the death rate in the exposed group and increase the death rate in the unexposed group." Other studies of this same accident were also fraudulent according to the same court documents, including a study by R J l Susklnd published in the Journal of the American Medical Association? "This published study of the workers exposed in the 1949 accident reported only 14 cancers in the exposed group and 6 In the unexposed group (a smaller cohort). However, the medical records produced [by Monsanto] to the Plaintiffs conclusively prove gross miscalculations and omissions-, there were 28 can cers in the group that had been exposed to dioxins in 1949 as opposed to only 2 cancers in the unexposed group." Mr. Suskind published two other reports17 on the same accident using his same data, to reach the conclusion that dioxin does not cause cancer. The B A SF Case On the night of November 17,1953, a runaway chemical reaction spewed dioxin-contaminated chemi cals over workers and community residents of two small German cities, Mannheim and tudwiqshafen. Subsequently, an epidemiological study was used to deny workers any compensation for ailments they daimed they suffered as a result of exposure. In keeping with German law, the workers retained their own expert to review the data. Their expert Friede mann Rohleder, received the data from the German government but found, to his surprise, that all the data T * ( actually cam e from the B A S F com pany itself. He " analyzed the data and found that so m e w orkers suffering from chloracne, which is universally ack now ledged to be evidence of high exposure to dioxin, had been placed in the low -exposure or non-exposed group. He found evidence of "diluting' the exposed group with 20 plant supervisory staff w ho, Rohleder believes, were not exposed. W hen R ohleder omitted the 20 supervisory staff, his an alysis revealed statisti cally significant in crease s in two gro u p s of cancers: can cers of the respiratory organs (lungs, trachea, etc.), and cancers of the digestive tract. 'T h is an alysis a d d s further evidence to an association betw een dioxin exposure and hum an m alignancy," R ohleder told New Scientist [To be continued.] 'Cate Jenkins, "Memo to Raymond Lcehr. Newly Revealed Fraud by Monsam o in an Epiaemioiogicai Study Used by E P A to A sse ss Human health Effects from Dioxins," dated February 23, 1990. Jenkins is a chemist with the Waste Characterizaticn Branch (O S 332), Characterization and Assessm ent Division, U.S. EPA, 401 M SL, SW , W ashing ton, DC 20460. Loehr is Chairperson of the Executive Committee of the Sce n e s Advisory Board (A-101), Office of the Administrator, U.S. EPA, 401 M SL, SW , W ashing ton, DC 20460. The Jenkins memo has attached to it 25 pages of a brief filed in Case No. 5-58-0420, in the Appellate Court cf Illinois, Fifth District by attorneys suing Monsanto on behalf of plaintiffs who say they were harmed when a Norfolk and Western railroad tank car derailed, spilling 19,000 gallons of a Monsanto chemical called OCP-crude" into the community of Sturgeon, Missouri the night of January 10,1979. Chief attorney for the plaintiffs is Rex Carr, 412 Missouri Avenue, East S L Louis, !L 62201; phone (618) 274-0434. O ur thanks to Margo Blackwell, People Against the Incinerator (PATI), Bloom ington, Indiana, and to E P A official William Sanjour, both of whom independently sent us the information about Monsanto. W e can mail copies of the Jenkins memo and attachments (28 pages) for $14.00, which covers our actual costs of photocopying, handling and mailing. *Oak Ridge National Laboratory. Toxicologies! Profile for Z3,7,8-Tetrachlorodibenzo-p-diaxin [ATSDR/TP-58/23; PB89-214522] (Springfield, VA: National Technical Informa tion Service, June, 1989), pg. 22, identifies dumns and incinerators as th e important sources of 2^,7,8-TCDD exposure to the general population." This is the Agency for Toxic Substances and Disease Registry [ATSDR] toxicological profile for dioxin (See RHWN *169.) * Stephanie Wanchinksi, "New Analysis links dioxin to cancer," New Sdentist October 28, 1989, pg. 24. Thanks to Paul Connett of W ork on Waste USA, we have a copy of Fried8mann Rohlederis paper, which he presented in late September at a dioxin conference in Toronto, Ontario; Rohlederis paper is entitled "Dioxins and Cancer MortalityReanalysis of the B A S F Cohort." We can mad you the 14page Rohleder paper for $7.00, or you can reguest a copy directly from the author: Friedemann Rohleder, Friednch Hebei Sir. 13 ,1 7 1 2 Weme, West Germany. 4 Zack, J A , and W. R. Gaffey, "A Mortality Study Of W orkers Employed At The Monsanto Company Plant In Nftro, W est Virginia," Environmental Science Research VoL 26 (1983), pgs. 575-591. *R .R Siskin d , and V.S. Hertzberg, 'Human Health Effects Of 2,4,5-T And Its Toxic Contaminants,* Journal of the American Medical Association, VoL 251, No. 18 (1984), pgs. 2372-2380. R.R. Suskind, "Chloracne, The Hallmark Of Dioxin In toxication," Scandinavian Journal of Work, Environment and Health, VoL 11, No. 3 (1985), pgs. 165-171. 7R J 1 Suskind, "Long-Term Health Effects Of Exposure To 2,4,5-T And/Or Its Contaminants," Chemosphere, VoL 12, No. 4-5 (1983), pg. 769. Rachefs Hazardous Waste News is published w eekly by Environmental Research Fom daflcn, P.O. Box 3541, Princeton, NJ 08543. Ed itor Peter Montague, PTl D.; Associate E d ito r Maria B. Pellerano; A ssistant ErSor. Am ette Eubank: W est Coast E tfio r TTm Montague: subscriptions : Abigail Alien, Office M anager. 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