Document xJnvLpOYjb9Dw4NOdaZenZ2G

FILE NAME Quigley QUIG DATE 1972 DOC QUIG046 DOCUMENT DESCRIPTION Published Journal Article - Cover page with Summary only A.P. Ostir E.K Hami H. Stanley W.EM.cCoy MAY 24 24 1973 the entire I have have needed needed article it Fleury Lee Mechanisms of Mesothelloma Induction With Asbestos and Fibrous Glass Mearl F. Stanton and Constance Wrench Leberctory of Pathology National Cancer Institute Bethesda Maryland 20014 asbestos types of in 7 forms 6 types of ^'brousgiam SUMMARY Three of silica and 2 types of metal particles were applied on a Abrous 2 types vehicle to the pleura of rats In 2 years amosite chrysotile and 4 glass of crocidolite yielded equally high incidences of pleurai dmiefsfoetrehnetlsipoemcaismiennsthe range of 58-75 % milled crecidolite Abars not oils or maallic maallic milling yielded related tumor exposed to extraneous reference milled crocidolite responses comparable to those of a standard caused Standard crocidolite inducing a high incidence of mesotheliomas fewer mesotheliomas 20-32 when reduced to submicroscopie Abrils milling Pulverized fragments of the steel mill and nickel by excessive levels did not induce metal at doses exceeodfinngoncproytsetnatlilailnecsoinlticaamirneasutlitnegd in a single mesotheli- tumors Microspheres 48 rats The intact fibrous glass vehicle did not yield tumors o nomradiadmoitns gabsence alter the incidence of crocidolite tumors How- 2 when the fibrous glass vehicle and other types of fibrous glass ever diameters from 5-10 ...were reduced to short farova fragments and applied to the pleura 4 masotheliomas were induced among Two forms of an especially fine fine fibrous glass ranging from 0.06 3 9in1 driaatmseter further milled to approachaproach the length of asbestos fibers resulted in moderately high incidences of mesotheliomas in the range of 12-18 % . Thus carcinogenicity of asbestos and fibrous glass seems primarily related to the structural shape of these materials rather than to physicochemical propertiesp.roperties. Nat Cancer Inst 48 797-821 1972 MESOTHELIOMAS of the pleura and antecedent fibrous plaques comparable to those resulting from asbestos exposure in man can be induced readily in the and hamster by direct intrapleural application of asbestos 7-8 Such attest to the caremugemcity of wa experiments bestos and offer an excellent means of investigating those carcinogenic mechanismis involved 453-466-12-15 453-466-12-15 Three years ago we began experiments based on initial investigations suggesting that quanti- tauve data could be obtained if treated rats were observed for 2 years 7 Asbestos on gelatin * Received November 3 1971 accepted December 8 147 National Institutes _ of Health Public Health Service U.S. Deparunent of Health Education and Welfare 797 CANCER INSTITUTE 48 797-821 March 1972 N.J. N.J. Bayonne Bayonne Bayonne Bayonne Bayonne Bayonne PENGAD PENGAD PENGAD PENGAD PENGAD PENGAD 09 13084