Document xJ7rbXM14opK2Q4VJNJg7kE6
AR226-2794
|
00 DU PONT use OnLy
Approxiaate Lethal Concentration by Inhalation (ALC) of
--
Haske! Laboratory Peport No. 293-85 " fm]
. 1. du pont de Neaours and Company
Haskell Laboratory for Toxicology and Industrial Medicine
|
P.New0a.rkB,oxD5e0l,awaErlekton197R1o4ad
DDaattee RIesvsiusede:d:JuDneece3,mbe1r98531, 1985
`Company Saniized. Does not contain TSCA CBI
HR 293-85
|
Approximate Letnal Concentration by Inhalation (ALC) of
|
S----.
Sumary
:
aust Taotmodseptheerrmeisneofa ALC.ForgroaupSsingolfe,6 mSa-lhoeurCrp1e:rCiOo8d(,SDf)oBlRlorwaetds bwyerea e1x4p-odsayed to
erxepcoosveedryfopreri4odh:oursARTtoE" detegrnaacionfnialnlgy alnethAaLlC.`a2ndgarpopuprsoxiomfat1e0lymal1e/10rtahtsofweare
rTaettshalwascoenxcpeonsterdatisoinmuTotblnecfuslyFortosaacihr toenslty. grFoiuvpe, aratcsontpreorlgrgoruopupweorfe 1k0imlalleed
oofn rtheecovSetrhydafyoroaf grreocsosvereyx,amiannadti5onraotfs tpheer glrioveurp.were killed on the 12th day
mateUrnderater tsheecaorndeitdiomnesdeorfattehliys ttoerstt,? btyh"eTaAhLaClatoTBTrgs 590 mg/m'. This
and 1Riavtesr-teox-pboosdeydwetolg6h7t mrga/tmi'oshaodnstihgenifStihcaanntdly12etlhevadtayesd amfetaenrleixvpeorsuwreei.ghts
i
Rraattsiosexponosetdheto12t5h90damgy/ma'ftehradexspiogsnuirfei.canLtliyvereleweviagthetds 1fiovrert-hteos-ebodryatsweiwgehrte not
-
TSiivgenrifwieciagnhttlsy wdeirfeferseingtniftihcanantcloyntdreoplsresosnedtheon5tthheda1y2thofdaryecoofverrye,covaenrdy.mean
HTooswseveirn,raTthseseexpsoeseemdingtoly59i0ncnon/sni's.tent changes were due to severe body weight
discolGorroesds p1aitvheorslogwiitchepxraommiinnaetnitonloofbulraartspaetxtpeorsnesd itno 45/950 rmagt/sm'kirlelveedaloend the
i
Stthhe d1a2ythodfayreocfoverreyc,ovearnyd. similar gross liver lesions in 2/5 rats killed on
||
vorkbya : [dtl Lari
14SEC
1
Technician
Study Director*:_ atira 7. MKinnoey o 4/3/25
|
Chemist.
toproved br: __ ancy Gace
o/s ms
UK:sak:HLRD1,4
AcSuetcteioInnvSeuspteigravtiisoonrs
i
cz.
~~
|
Revised
Haskel1 Laberatory Report No. 293-85
w"vo. [E--]
Haske! No. 15.437
4
|
Material Tested:
Nonanoic. acid, heptadec .f1uoro-, ammonium salt
ii
Sponsor:
uP.iotlmy1i.mnedgrutoPnar,ondtDuectldseawaNDreeempoaurrtsaenatnd Company
i|
Material Submitted by: Ps.olyC.merMalPhrootdruacts Departaent
|
i P.ark1e.rdsuburPgo,ntMedsetNeVmiorugrisniaand Company
-
Lali Test Facility:
EH.ask1e.11du LPaobnotratdeoryNefmoourrsToaxnidcolCoogmypaannyd
|
Industrial Medicine
P. 0. Box 50, Elkton Road
||
Newark, Delaware 19714
4
i
3
|
Study Inftiated/Conpleted: 1/3/85 - 2/3/85
|
There are 15 pages fn this report.
3
Distribution:
[|
3
|
-3Company
SanitaedDoes
not
contain
1sCACE
g ii
INTRODUCTION
HLR 293-85
-9 iTnnemapluerporsaets.of TthheisALsCtudwyaswdasefitnoeddetaseratthenelaoweds-thouatrmoisnphhaelraitcionconAcLCentfroar-
etxiponosutreesteodr wtihtahtincau1s4eddaytshepodsetathexpoofsu1reo.r moIrneadrdaitstioeni,thefrollonowitnhge tdhaey of
edfefteecrtmsinaoftioCn-9offahtahleatAiLoCn, oanddittheionlailvere.xposExucreepstwaesredoccounmdeunctteedd tino tmhoenitsoturdythe
i
Prreaccotridcse, Rtengiuslasttiuodnys.was conducted according to the applicable Good Laboratory
MATERIALS AND METHODS
A. Animal Husbandry
BreedYionugngLaadbuolrattomrailees,CrlKi:nCgDsOt(oSnD,)BRNewratYsorkw.areEarcehceirvatedwafsroamsCshiagnreldesa River
cuanridqueaff6i-xdeidgittoitdheentciafgiec.atioRnatsnuwmebreer qwuhaircahnt-ionrerdespfoorndeodnetoweeaknpurmiboerretdo
|
---
pteersitoi.n'g, aDnudrinwgeretheweitegshte,d arnadtsowbesreervehdoustewdiceindupariirnsg tinhe8"quxara14n"tinxe8%
|
Snuusmpbeenrdeidn,'eascthainclaegseswassteeildenwtiirfei-emdeshbycaagessl.ashThine trhaet raisgshitgneeadr.thePrlioowrerto
|
eixnpsoosluurbel,e mraartks'erstaislosthaantd ciangdeivicdairadls wreatrse ccooullodr-cbeodeiddewnittihfiewdatearf-ter
aenxdposwuartee.r weErxecepztvadiu.raibnlge aedxpolsiubriet,um.Purina Certified Rodent Chow #5002
8. Exposure Protocol
betweTeond2e3t4eramnidne2a9n8 gALrCa,ms,growueprse orfest6rariatnse,d inwpeeerkfsoroaltdeda,ndswteaiinglheisnsg steel
acylsiinngdleer,s w4i-thhourcopneicrailodntooseapdluesctes.atmoEsapchhergerooufp Cwa-s9 ienxpaofsre.d nRoastes-ownelryefor
wtoexiigchietdypdruiroirngtoexepxopsousruer."e, Saunrdviwveirnegorbastesrvweedrefowreicglhiendicaalndsoibgnsserovfed daily
bfyorth1e4 rdaaytss'pcoostndietxipoons,ure, weekends excluded except when deemed necessary
|i
ats,TomwoeneiktsoroltdheanedffewcetisghionfgC-b9etwienehnal2a3t7ionandan21t7hegriavmesr,,ve2regrroeuspstraoifne1d0
31
i |
eaxnpdoseuxrpeosceodncteontaramtairogninoafllyC-9l,ethraelspeacntdivaeplpyr.oxinTawotelgyrou1p/s10otfh o1f0 aratlse,tha8l weeks old and weighing between 231 and 267 grams, were restrained and
exposed to air only, Each control group was exposed concurrently with
-4-
f
Company Saniized. Does rol contin TSCA CF
i
I
:
HLRRe2v9i3-s8e5d
eoxnpeosoufret,heantdest rgartosupsp.er pathologic examination of
gFriovuep rwaetsre pekrillgerdoup12 wdearyes kaifltleerd the liver.
e5xpdoayssuraeftfeorr
C. Jest Material
|
PPuhryistiycal Form:
Synonyms:
-- hice-- solid)
Amon{un perfiGorononanoate
|
one cones:
Stability:
[Cg9 --]
he Test naterial was assumed to be stable throughout
|
the test.
U. AtmosphereGenerat ion
|
||
rKe-gTurloFanotsredSmiownsittFheeexadpeorsKu-rTserasos,inysodeVudsotluwniaetthtmroiSscupihneFreeefsdeedCofonstcCrr-oo9lrlsweeerr,eTeg.Tehneefrobnaidtnedrfaveweeidtehsrasa
|
i
etmxuepbtoeesruesrdweepttcehsattshbmeuartt.eersitaTlmhaetiecnryticoalloanetghlrraeosmsuogvhterdaanlssafirezgree-rtpueabderu.tciicnlgAeisrcybciylnotnirenoedrautncideadlnattotthhee
---
iinmtpoacttiheon,(xpwohsiulree acehraoadbyenra.mic Thpearattimcolsesphepraiscsedcontchernoturgahtitohne controlled by varying the feed rate.
ocfycCl-o9newaasnd
!
|
i
fblyaspkaFsosartintgthheeprlbeooswtsetusortmizeeoxdfpotashiuerregthecrnooenurcgaehtnotraras2te-irsovtne,adgetahsgelaaastdsmuosgstepnherereraseteorwrva.osirg.AenreoAruantded
!
iscntyticrrlorodinunecgeedlrouadttrwiitathtieorbpolwtaatssotimicnosfpeardttdheeidesraebsoaevgreivtoatithreedarndedussetartviiotnrh.ethceyAcglmeoonntesroartieozlreu.dtriaAtforr
{
csownecpetntdruasttiopnarotficCl-e9s wianstocotnhteroelxlpeodsubrye vcahraymibnegr.theTh2e aaitrmfolsopwhse,ric
|
E. Analytical
i
30-miTnhueteatmionstpehrevrailcs through preweighed,
GbceyolnmcdaernnatwgirlnaagtsisocnalfoiibfberraCt-fe9idlwtvaesorlsud.meetseFriomlfitneecrdhsamawtbeerraepapwtreimgohoexdsipmhaetreeol'ny
J 4
|
oafCpaahnrtinocduel]ate26weAsutdoemtaetrincinEeldectfrroonbaltahnecefs1,iterThweeighat tmosdpihfefreircenctoinaclenbterfaottraen
and after sampling.
HH 3
druersipniPgraarbetlaiecc)hleewxaspsiozsdeusrte(e.d'ragsisneDmuderdiwiniagtnhmaoaesrtSofdeeyxrnpraoamsiucmroeddsei,lamc2eh1ta0emrbceaarsncdtaedpmeepreciremanpttaucrteorwas
ZiA ef
E
ioiHf ed
1
"5% Company Sanilied. Docs notconain TCACHaES
|
HLR 293-85
||
ameBaesnudriexd nwoidteh] a5m6e6rpcsuyrcyhrtohaeertmeorm,etearn,d crhealmabteirveoxhyugmeinditcyontwaesntmweaassurmeedasuwrietdh
with a BioMarine model 225 oxygn analyzer.
F. Pathology
-9 iTnwoaigrr,ouapnsdof2 g1r0ourpastsofwer1e0 reaxtpsoswcearefoerxp4osheodurstotaoir67onolry.590Fimvge/mr'atosf
apnedr egxrsoaunpguwienreatiaornbit5rdaaryislyafsteelrecteexdposaunrde.kilTlheed rbyemacihnlionrgofo5rrmatasn/egsrtohuepsia
wweerree wkeiilglheedd.12 Mdeaayns alfitveerr weexipgohstusre,andRa1tisvewre-rteo-bnoedcyrowpesiigehdtanrdatitohse floirvers
Dtiefstferreantcsewaenrde CDuonmnpeatrte'ds totestthse.ir SriegsnpiefcitciavnececownatsrojlusdgbeydLaetasttheSig0n.i05ficant
|
probability level.
|
G. Records Retention
HaskeAlT1I LraabwordaattaoryandfortheToxfiicnaollogryepaonrdts IwnidlulstrbiealstMoerdeidciinne,thNeewaarrckh,ives of
|
CDoemlpaawnayr,e,'orIiinngttohne, DDuePloanwtarHea.ll of Records, E. I. du Pont de Nemours and
RESULTS
A. Exposure Conditions and Associated Mortality
materiDaulr.ingCmhoasmtberextpeomspuerreast,urtehse rcahnagmebderbewtawlelesnwe2r3-e27coCa,tedrelwaitthivethe test
Ahturnofsdpihteireiscrcahnagreadctferroimza1t9i-o45n%,andanmdorcthaalmibteyr doaxtyagenarecoSntuemnatrsizweedrefn21t%.he
i
following table.
-6- Gomyary Saniizes. Goes ut contain TSconCc A
=Carsacntdertszoactiotantedof Ra-t9FoArtcmaotsipeheyres
2 293-85
BeCaonncent5r.0a.tion R(nagn/gne'
2AN 160
71600 40
w100-110w0 0-10
4600 600 4100-300
s9&0 230 m1o21120
tespi: ravle'
o9e 390 s7s%
MOLm)' n
b2.s4 p3ed 355
(5 deHaotrntsassiteyrposed) aosrss o6//s6 1754
3 MPaesrscemnetdibaynwaeiegrhotdynoafmipcartdiacnleetserw.ith serodynanc diameter fess than 10 un.
4 AeExlxatpmhoiosnuuagrtheisotnhfiosorfesxtuphbeosseurqrauteesn,twasp1a/5tchoronadltuoscgtiecddeseixfgaornmaitnseaudtbisotenoq.uebnetkiplaltehdolo1g3icdays after exposure ded on the 126n day.
8. Clinical Observations
|
6l2o0wemsgt/Dau~er"xipnogasnduorre16i0cm0omnegcde/inamtt"ge,altyiroafntossllhhoaawddingrteesdetxopmroastuberrreoi,walsfooennceiatrlhaetidsrisehcxehpaaodrssge:eds.tRoatAtsthe 5
|
edixspcohsaerdgetso, heads. All
4ra6a0td0singdi/inmei"dshdehudardisntlgaarbetoxlrpeeodsruebrsrepeoatntoshei4n5ga0,n0dpmrtoegfsmuts.meatcelreiaarl
naonsaltheainrd
oral
i
ead9xa/pyaos"ssupBroduesir.teidngeRx1ap2ttohsseduaerypxeso,psoptsaoeensxddtpaet6sox/up6ro6e7sruapmrtegesr/,imeo"xd4p,/o6lso1esr/tda5tst1r-oe9em%x1ap6ioo0nfs0iendimgn/inort'a;it9asl1d0iebexodnpdgo/y4sa-esw8deiddtgai:hyetsd59p|09o-s1t1
wgdeariyegahtpteosrt1tdheaaxynpops6o7usrten,/eaxfpq,oislurorawete,sd albnyodstncoraompnatplirnouxweiedmiagttheotlyTgoas6ie-n1.w5e%iAgtohftcioenniicttehinaetlrrabtoidoyns
etWthexheiprgoohsruteegcdhowovhuteetorny5t9thp0he,eeryri6eow2cde0o,rveoerrresysa9pc1per0ecirtfimiaio/vcdnee>ldgyr.w1e2uingdtahiylesd tpohoneslytydei5xe4pd-o.7s1u%rMeoefsotrTsnatuttrivati]hveibnsgunydraotfs
ctohnrcoeunghthoroauattdivoetnhrsese{rcnelccilonuvtdeceradylhpuesnricighoneds,dvpeorCseotmumorobens,ecrrlviuenfdifciiaenld rosaritgsndsiesxcpatoo.lsoheridegdhteorfu6r7, mrye/dn
or.
CompanySeniized.Dossnotcontain TSCACB)
|
HLR 295-85
I
oorr blraobwonredfacbiraelathdiinsgc,harlgeetsh,argwye,t olrimpsnteasisn:andperhianireunl,ossp.alloCrl,inilcuanlg nsioginsse
were abserved throughout the recovery period.
C. Pathology
largeGr1oisvserspatinhol5/o5gicratesxamkiilnlaetdiononoftherat5sthedxapyoseodf troeco5v7ermyg./m'Afrteevreal1e2d ndga/yas'o,f47r5ecorvatesry,kilnloende oonf tthhee r5tahts'day11oefrsrewcoevreer,notheadd adsiscloalroger.ed Aitve5r9s0 wpriotbhabplryomiantetnrtibultoabbulleartopadtitefrfnusseorfamttayrkicnhgasn.ge wTihtehseapaztontaelrnsdiswterreibution. OTnhethPeath1o2ltohgydayrepoofrtrecisoveartyt,achgerdossas lAipvpeerndliexsio1n.s were noted in 2/5 rats.
weightSstatainsdti1ciavlera-ntao-lbyosdeys wsehiogwhetd sraitginoisficinantrlatysel~exvpaotseedd mteoan6}lnigv/ear'y on
Ggrootuhp,thmeea5nthlainvdertwheeig1h2ttsn danadysloifverr-etcoo-vheordyy. weIinshtthera3t9i0osmg/wme"reenxoptosure
S12itghnidfaiycaonftlyredciofvefreyr,entmeafnromlicvoerntrwoelisghtosn wtehree5tshigndiafyicoafntrleycovTeorwye.r thOanntne
celoenvtartoelds.; hoTwheevelra,ck 1oifvesri-gtnoi-fbiocdayntwei1gihvtarrwaetiigohstwcehraengseisgnoinfitchaentlSyth day of
-
Freeccoovyeerryy,"waenrde dtuhee dteopraeslsaerdgeng1a0nss1oifverbodwyeigwheitgshtonintherat1s2tehxpdoaysedofto 590
n4g8/%a"o,f coMnetarnolbsodoynwetihgeht5sth faonrdra1t2sthedxapyossedoftorec5o9v0ermay/,mreespreectiovnellyy.70% and
HStoawteivsetri,camleanana1liyvseers woefighmetasnwe1riever83w%eiagnhdts72a%ndof |ciovnetrr-otlos-,bodryespweecitgihvtely.
]1
Patios are presented in Appendix 11
i
coNcLusIon
matUenrdiera1lsthceoncsoinddeirteidonsmodoefrattheilsysttouxdiyc, btyheiAnLhCalaftoironC-9(AwLaCsbe5t9w0eemng/n2'0.0 anTdhis - + m3g0/0m'gg/ona)t.he "SHtohweavnedr,1C2t5h cdaayusseadfteelrevaetxepdosu|r1ev,eranwdeigghrtosss in11vreartsleexspioonssedfnto 67
rats exposed to 590 n/n'.
|
p------------------------
! CIanlscturluacttiioonn Mdaensucarli:bedSeirnteSster2r1a0 AInnbsiternutmeCnatss,cadIenci,npaBcutlolrestinand7-79C-y2c1lo9nIeH,
Frit aeSepriesa21r 0 dsba lenttCascradesIapeancd tCroclronse
Ja Company Senile, Docs not contain VSGA C31
pr
tppent 1 {--
|
|
|
-9-
1scacal
1}
P--J Sontized. DOS not contain
E. I. ou PonT 06 Nemours & Company
HuaweinLdWaousRTHoALmrMoaEmTDToImoAcomvoyar Ne0waBnxo.x3D0,eEwxatrosnh18o7s1e1
ic
sss
cr
[C-- oD] ses
woe
1s
NOKANOIC ACID, --
2,2,T3,3T,6W,6,e 5,5,d6,6,w7,7,i8,8Ti ,9T,9d-HT EaXADiECAFrP LUO'RO,-
e
---
APPROXIMATE LETHAL CONCENTRATION (ALC) TOXICITY STUDY
IN MALE Cr1:CD(SD)BR RATS
|
||
| GROSS PATHOLOGY
]
PoLYIER PRODUCTS DEPARTMENT
i
|
1
DATE ISSUED: YAY 16, 1985
S10. Company Saniiznd. Pp--
Cae Ac ToxterTy stoby tn wae ars vin c-9
tatroduct ton and Resuits
CnxepcoruouMpraseli.eedCraM1ned:cChDoIdi(vSeorfDs)cBuRvcerhreaantkwssetiesgxhpevodasszdacndhtlooeCrx-ea9rmionrfeeodrana4etsht5ohuersssuida.vi1a3anad{oorrhosaaltmaotomirtoeinnawcetroen.
|| i
VnoobAtsLeedrnvTaaaatstbilobelenasrIpgermtedasaedetnnttanietefdcirenosiepncartyoth,hpeissyhe.oxwrpeeovpTseohurrer,te)LiLgvIirnevodreuirpcsoafwteea.iongndhlthaycasotan.t(cavfhteoen'tusgnebeircsvoheseneocgnosrforososoirtseaetoierieecv,asaesd
psffoaanrttitetniyaoelnxscahmoav'fnagsoetdhTewaiortingnhec.draaeyaTzsh3oeenpaiopnsr4to1-mlseiitxnvpeeFonritsvsueirTizeooebnu1msla(aycraoonubptteartidc1uilokeorebnluvylo.saorsFraeecdoreriyfmpncotrsahinamotrifesse5itehrLyarcsBgeorrrImFeoo,rseit
ctnh3ed"socoportemapsoTauienkdreleaytndfcehuatlthuamtt.hecheLiIvnecrrefasuen.ctiInonsaisaen itshedopsritaoar3y pcereoetbaorreeeasteorotorterkeofn
--~
Acknowledgement
Joan A. Wolfe vas pathology supervisor for this study.
sevore trLThu eodore r -1)SiSoe oampeo:
i
SDiepaltomPaattehoAi.oCp.iVo.tP.
|i
.
Approved by: +
MaSnagoer,mFacheolrogey. Divioton
!i -|
TStSonvECK3/1u3ta
|
im
|
-n- siaed. Does sotcontain TSCACBBlY
Company Sanit
fe
=
Sa
La ssp MALE RATS -coINHALATION
|
NAansabler TDearve RecDoavyesry Mboedaecahf
Observatfosns ens_
|
Bel 65
Liwvae)r, - lderftscolloobreation, dark red area, (5
|
wees 6 5 S$ Ho abnormalities detected
!
386620 6
5
sD
N> abnormalities detected
smes2z 6 5 SO No abnormalities detected
e620 6 5 S$ No abnormalities detected
me67 13 12 $0 No abnormalities detected
"
#6619 13 12 SO No abnormalities detected
mez 13 12 SO No abnormalities detected
e623 13 12 e625 13 12
SO No abnormalities detected S$ No abnormalities detected
i
Group 18 = control
|i
Wm 386988 66 55 sD wNeo aabbneoorrmaatlticttieens ddeetteesctteedd
e992 6 5 $0 No abuoraslities detected
86996 6 s S$ No abnormalities detected
6996 6 s $0 No abuormalictes detected
3698 13 12 SD No abnormalities detected
e991 13 2 SO Mo abnormalities detected
:
|
386993 13 12
No abnormalities detected
]
- 350 =Sacrificed by design: 70 = Found dead
32+ Company Sanitized. Doss net contain TSCA CBI
R
Su-
f-15437
Tae1
Pare 2
- =]
HALEGRRAOTSSS -P=ATIRSOHLAOLGAYTION
|
ASnoimmbaelr TDeasvte RecDoavveery MDoedaethof
Observations
.
386995 13 2 386997 13 12
SO No abuoraslftfes detected $0 No atormalities detected
Group TY = High Dose (0.59 sg/L)
desis 6 s S$ Livperroat-nednitscoloration, lobular pattern
meses 6 5 $0 Lipvreorat-nednitscoloration, lobular pattern
|
-
essz 6 5 $0 Livperroa=tnednitscoloration, lobular pattern
|
Besse 6 5 S$ Livperromi-nednits,coltaonrasttiroen,akslosbcualtatrermeadrkings
}i |
6567 13 12 $0 Livienrd=lamfeotcetr,),whailtle,losbceasttered, (< 2 mm
{|
doses 13 12 F No abuormalities detected
;
wessL 13 12
so No abnoraalities detected
i
e553 13 12 $0 Livleefrt-lodbies,col(<ora2timonn,insdmailals,etewrh)ite area,
||
Perineun - alopecia, moderate
i
!
e655 13 12 SO Dorsus - alopecta, right, moderate
}
Group III = Lov Dose (0.067 ag/L)
|
03 6 5
Liver - large
|
387035 6
5
so Liver - large
EN
S13 Company Senltized. Does not:ontain TSCA CBI
fe
.
=
-s-
(i 3
cross opasTROLOGY JALE RATS - INHALATION
nial Tent Recovery Nodeof
m----
[
Susber Days Days= Death Observations
'
387037
6
5
so
Liver - large
87039 6 s Liver - large
wo 6 s Liver - large
won 1 12 No sbuormalities detected
won 1 on $0 No abnormalities detected
wow nu S$ Mo sbormalities detested
wi 1 on SD Mo sbrormalitieu detected
-
wiz 13 12 So No abnormalities detected
|
`|
i
i
.
.
]
1 ER SSCAo |
A
i
1 sons 11 HR 293-85.
C3 MEAN LIVER WEIGHTS AND LIVER-TO-80DY WEIGHT RATIOS
RATS SACRIFICED ON THE STH DAY OF RECOVERY
i
ove
FINAL WT.
Liver
WLEIIVGEHRT-TR0A-T80I0OY
|
T5C7 oMGNM TROL22,7756T.166 ((001.901020)) | 11411.530016 ((00..000002)) 54..206930 ((00..000000)#
!
C59O0MRHOaLi{I 229036.04 ((00:.000000))s 1124..051101 ((00..010604)) 45..984053 ((00..000803))
|
i
|
+Val-ueSstaniinfpicaantrlyednifft-erhePnoetvfast(lrpue<eeadt-os0mf8e)ntStfmuredoamenncto'tnsotrcoolnttersgotrloucpmoemabpnya.rLiSsDon |
]
{
#2 SigDnuinfniectatn'tsl.ytdesitfferent (p<0.05) from control group by LSD and
3
-i
CO - MREAATNSLSIVAECRRIFWEIICGEHDTSONATNHDE LI1V2TEHR-ATOY-B0OFDYREWCEOIVGEHRTYRATIOS
i
j
Grou
FINAL WT.
Live
VLEIIVGEHRT-TR0A-T8I0O0Y
i
]
|i
8C7ONWoT/RKOL. 331255.04 ((00..030704)) 2104..387016 ((00..000001)) 46..627688 ((00..000000)4
31
ii
C590OMLL a160m.0 ((00.000000))s 1118..18978 ((00.000002)) 47.600S3 ((00..000000)%
33
| 32 digg anes GREETS ; I|
"Va+lu= eSsigniinfipcaarnetnltyhesdeisffe-renoPtf v`a(tl0rue.ea0to5mfe)ntSftmrueodamenntco'tnsotrcoolnttergsortloucpmoemabpnya.rLiSsDon
EF :i
:
Dunnett's test
a
f
.
hwaek 3
rv
)
|1
CSosmpeany ELpnts Lia il
:
|
cra sEstec Mo bevEoTENT DEPT
|
To Ren. Teo HASKELL LABORATORY FOR TOXICOLOGY
! ey
=n
JHl 4
iw d di
December 31, 1985 |
~ | ----|
Anendnent. to Haskell Laboratory Report No. 293-85
if{i ji
0B oe ER : ; 8,Tlih9se,t9ec-dhheeomxniacdapelacgaeatbl3sutororafoc-tt,sheanmarmmeoepnoirfutomrasasamlNmtoo.nnainuTomhiecpeacrcofirldru,eocrt2on,co2hn,ea3mn,ic3ca,at4le,a4wba,ss5t,i5a,c6t.s81,.908a%y.Ma.
|
||
!
ig
bieseNnonraenvoisiecdactiod,inchleupdtea.detchaiftluboorroc-,asatmimmonium salt. Page 3 of HIR A
Ei
Thegeosthoefr cthoedce ofroro RR fluor Te cteirwas icnocdoerrneacmtel'y
SoEt
Ii 41
Study Director:
TR ."Taura A. Chemist
}i: E Ii:
30238 =
ii
i
il
ee a g
5
Gf
b!
:
Acute Invesont,iSguaptei:ons Section
:
aii e&
aay
ii
id a
aralt iid
H a E
i i
-
i
coy on
sp aLTOos nitcontain TSCA <2 Lgael
scam
i
Hide