Document xDV0qwv98Y8LygZ4bERZvqB1

November 20, 1957 Mr. M. J. VodlUe Engineering Supervisor Worthington Corporation P. 0. Boa 956 Buffalo* New York Dear Nr. VodlUe 1 X heveJMwi aaked to forward to you toxicity information on fydraul Af and rydnuil 150. Xn animal toxiolty etudiea with fydraul AO* the oral lethal dooe In rata ia approximately 40 grama per kilogram and for ~ rabbits, 3.9 to 4.5 grama per kilogram. The greater aeneltivlty of rabbita la typical of this type of fluid, Thia lethal doae la of aueti an order* however, in either eaae* that the fluid may bo oanaldared only "slightly toxic" to man from the atandpolnt of aeoldantal ingeatlon of aingle oral doaea. The fluid may be abeorbod through the .wjbrgkon akin of rabblta in doaea resulting in death* but agaiif the, acee/is euoh that aeeidental maaaive akin expoaurea to man do not present a haaard. Skin and eye irritation atudiea with rabblta would olaaaify the fluid as a mild Irritant. laboratory animala aurvlved six-hour expoaurea to an atmosphere saturated with the vapora of the fluid. , _ - On the baala of the above data it may be concluded that fydraul AC requires no special handling precautions other than avoiding pro longed or repeated akin oontaet. Aoeidental aplaahing in the eyee will reault in moderately severe pain and irritation out no perma nent damage should reault. Similar data on fydraul 150 indicates that it is practically in nocuous shoo fed orally to rata ainoe the animals survived alible doses of 20,5 grama per' kilogram with loss of appetite and severe diarrhea as the only toxie effects. The fluid apparently ia not absorbed through the unbroken akin of rabbita since this speelea aurvlved doaea up to 9.5 grams per kilogram of body weight, Xn rabbit akin and eye irritation studies* fydraul 150 was no more irritating than a 100 soap solution tested similarly. As indloatcd with fydraul AC above, however, fydraul 150 will cause severe pain if there la aeeidental aplaahing in the eyes of humans, nets sur vived a six-hour exposure to an atmosphere saturated with Pydraui 150 vapora. > HONS 091011 Mr, M, J. Vodille---Page 2-~Movaciber 20, 1997 Although we Jwva not oonduoted analyses to determine the amount of Pydraul vapors in air from compressors lubricated with those materiala. we r#oi sure that the eoneentratione of vapors will be very minute and should introduee no hacards to uorioaon breathii the oomprossod air if it ia used for air masks. The amount of skin oontaet with the fluids in the ease of workmen servioii^ or maintaining the compressors would not be expected to be suffident to oause any difficulties, Zf Z ean be of any further assistance, please lot me know. Very truly yours. RBKidh R. 8kuet Kelly, M.B. Medical Birector bee 0. A. Oreene-Mew York V. A. Parent-New York M. 0. flummer-Ooneral Ofos. MONS 091012