Document xD5eMZzR8oJepo2oKjg5oR70

April 19, 1365 Your letter or Aor 11 1955 conccrninp to::!city data for Arcelor cl acc 1957 ao lean referred to r;c for reply. 'SC* on1ly fco;:icity cnfca in ao foilov:: vo have -ace Ursula tod since 1957 _ . i w w C* "W* vO* Ov . w^. 1^ TT\ ~ ^ > >-. J - v.. 4 m /.. 1..*c.<-J *-1* (*| j Cr->s/'~\y (16,5^-^2,511) when Area l or pi.oO van acLr.ir.i ; tc-red au a 53.3 portent solution * ** c.' "' *ri o * * ;*r*'."% h^*'* t */o "l_ tiro T.:a:r 5 to 5 daps. 9k o cor. 10 c lyno obr*o'vcci **/-5-ir1 o severe diarrhea, loro of appetite, lathar-y and. eventual ooilapee. Grocr, autopsy revealed inflame::; ci oh of oho- (*1 o f" 'pi? *> l/ -- V r tu r *' ~ -Jv*r'\,- f* rn /'* 1 o *%**", *.- 1 ^V Ka. Wtl < ^ Vi.iU f V.4M M w V< . ) W .. TV* J thic route of cuministration Arocior 5460 vrao classed */* Uw tvsirs J ^,/n ' 1 vt O' ^-NV-V _f* . ' * i <*% .`IVil U '.^V4 The application of a 33*33 percent solution in corn oil of free lor 3*.;5o to the clipped intact skin of fcr.aia *> V" ". *i ^ i r v! * X*' ' 'iV.'O:1 V1 :: 1 '* ^ .- r - *-* *j 1 at pp 1 ^.,rt Jj w.v.m -* J. j*. k J <__ ^ v a/ ' . _ U- f -. . - i-ei f of^ l... t -' i. i oho ramie. *fh2 only vneouaru oiync ccserved from this data' v:cro - reduced appetite and modorctn letkarpy. }'.y this route of aduinisoration Arcelor pool v;aa classed as practically non-tor.lc. DSW 379373 STLC0PCB4100145 Mr. Keroiit L. tfouror -2- Aprll 19, 1566 In a subacute- dermal study when a 50 percent (v;/v) corn oil eolation of Arcelor 5^-50 was applied to the clipped intact chin of rabbita at dorse of 100, pOO and 1000 r.p/irp/dny for O ' darn, the cl or a of 100 rr./'.':Z fail ad. to sbv.:r-a',y offset the body sight. The weight3 rare comparable to the controls. However, the 50 3 and 10 03 r^/la-; doe os produced slight to moderate!;/ adverse effects, respectively, upon tody v.-o iG-:t. ` * The 20 dry subacute dermal LT>=n was 230 mg./Ieg. Thera was Generalised inactivity, wedhnoss, lassitude ahd Iocs of appetite from the 5-00 and 1010 mg/J'g/bey do*: 03. These signs were net el served in animals v*i iv h received tha 100 i.y;/hr/day does. hrythema -regressing to subdomnl homorrnages was noted among animals of all test doses. 0 the nnrnibuda of the does, faring i :o i foils-,.any tire dosing t - > -. . ation ocriod lie of she anfrsa 13 C 3 ^ a' :.".o necrotic. areas began to slough off revealing new chin. The hematologic data and the results of urine analysis for the tost croups in this subacute study compared well with those of the treated control group animals. There were no significant gross or microscopic .CO tissue alterations noted arse::-; the surviving toefc animals so. srificed at the conclusion of the test which ::era attributed to atscrotior. of the test material, findings f jr th.e west animal.: more comparable so those seen In the treated control animis. . I trust the above will be helpful and if v;o may be service please contact mo directly. nor Sincerely. : "rT* ? . , r. 1 - 4 *,, l 4 J *w bcc: D. brcs.o Uilliam H. Hunt, Ph.D. Tonicolcgiet . Medical nemartr.ent .' DSW 379374 STLCOPCB4100146 6. A * Norden Laboratories, Inc Lincoln, Nebraska 68501 VETERINARY PHARMACEUTICALS. BIOLOG ICALS AND SURGIC.AL SUPPLIES April It, 1966 Organic Chemicals Division Monsanto Chemical Company 800 North Lindbergh 3lvd St, Louis 66, Missouri Gentlemen: For the oast ten years we have been marketing a Lindane concentrate containing your Aroeior pU60. As you know this material is used toDrolong the activity of the Lindane and is based on research originally done in l?5'a by the Department of Agriculture. On several occasions during past years the Pesticide Division of the U.S.D.A. have asked for data to substantiate the safe use of Aroclor in insecticides. I have recently received another such request and I am writing this letter to inquire if any additional toxicity data has been accumulated since 1957. Your assistance will be aooreciated. Sincerely, l'trLL'-x^ Kermit L. Mourer, Director Pharmaceutical Division KLM:db DSW 379375 STLCOPCB4100147