Document x5yoyGZnwroz2r4BRMNrr09dg
WARF INSITI-U-I-EI,NC.
MADISON,
WISCONSIN
Reportsare submittedto clientosn a confidentiablasis.No referenceto the work, the resultosr to the institutien any form of'advertieinnge,ws releaseor otherpublicannouncement may be made without writtenauthorizationfrom the institute.
REPORT
Sample: T-1166
WARF No. 5011023 Date Received: 1-13-75
Submitted by:
J. E. Long 3M Company St. Paul, Minnesota
Testing requested: Eye Irritation
Conclusion-.
Under the conditions specified the product has eye irritation scores of 7.33, 6.67, 6.00, 2.67 and zero at 1, 24, 48, 72 hours and seven days respectively for eyes washed after a five second exposure and eye irritation scores of 8.67, 11.33, 7.33, 4.67 and zero at 1, 24, 48, 72 hours and seven days respectively for eyes washed after a 30 second exposure.
The product is irritating to the eye.
Report approved by:
Signed q p , :@laanndd for WARF Institute, Inc. Date: January 28, 1975
Donald L. H&rris,,-D.V.M. U Chief Pathologist/Toxicologist
FORM 36 -4
Sample:
T-1166
WARF
MADISON,
INo"ITI'U'IEI,NC.
WISCONSIN WARF No. 5011023
Eye Irritation:
Method: Adult albino rabbits of the New Zealand White variety were placed in a collar such that the animals could not rub their eyes. One-tenth of a milliliter (0.1 gm for solids) of test substance was instilled in one eye, the other untreated eye served as a control. A series of three albino rabbits was used for each substance. The reaction to the test material was read according to the scale of scoring for damage to the cornea, iris and the bulbar and palpebral conjunctivae at 1, 24, 48, 72 hours and seven days after eye instillation. Any residue of the test material and accumulated discharge are flushed from the eye each time they are scored.
Administration:
Concentration of test sample: as submitted
Diluent or solvent: none
Special washing:
eyes washed with 300 ml. of distilled water over a two minute period, after a five second exposure.
Results:
Rabbit Number
Cornea Opacity Area.
Iris
Conjunctivae Redness Chemosis Discharge
1
0
0
0
1
0
1
1
2
0
0
0
1
2
1
hour
3
0
0
0
2
2
1
1 hour eye irritation score: 7.33
1
0
0
0
2
0
0
24
2
0
0
0
2
1
1
hours 3
0
0
0
2
1
1
1
48
2
hours 3
24 hour eye irritation score: 6.67
0
0
0
2
0
1
0
0
0
2
0
0
0
0
2
0
1
72
2
hours 3
48 hour eye irritation score: 6.00
0
0
0
2
0
0
0
0
0
1
0
0
0
0
0
1
0
0
72 hour eye irritation score: 2.67
FORhr 28-4
WARF INS I *I'IEN,C.
MADISON,
WISCONSIN
Sample:
T-1166
Eye Irritation:
(continued)
WARP No. 5011023
Results:
Rabbit Number
1
7
2
days
3
Cornea Opacity Area
Iris
Conjunctivae Redness Chemosis Discharge
no noted irritation all readings negative
7 day eye irritation score: 0
FORM 28-4
NWWARFIN
MADISON.
WISCONSIN
9INC@
Sample:
T-1166
Eye Irritation:
WARF No. 5011023
Method: Adult albino rabbits of the New Zealand White variety were placed in a collar such that the animals could not rub their eyes. One-tenth of a milliliter (0.1 gm for solids) of test substance was instilled in one eye, the other untreated eye served as a control. A series of three albino rabbits was used for each substance. The reaction to the test material was read according to the scale of scoring for damage to the cornea, iris and the bulbar and palpebral conjunctivae at 1, 24, 48, 72 hours and seven days after eye instillation. Any residue of the test material and accumulated discharge are flushed from the eye each time they are scored.
Administration:
Concentration of test sample: Diluent or solvent: none
as submitted
Special washing: Results:
eyes washed with 300 ml. of distilled water over a two minute period, after a 30 second exposure.
Rabbit Number
1
1
2
hour 3
1
24
2
hours 3
1
48
2
hours 3
1
72
2
hours 3
Cornea Opacity Area
Iris
Conjunctivae TZedness Chemosis Discharge
0
0
0
1
2
1
0
0
0
1
2
1
0
0
0
2
2
1
1 hour eye irritation score: 8.67
0
0
0
2
1
1
0
0
0
2
2
2
0
0
0
3
2
2
24 hour eye irritation score: 11.33
0
0
0
2
1
0
0
0
0
2
1
0
0
0
0
3
1
1
48 hour eye irritation score: 7.33
0
0
0
2
0
0
0
0
0
2
0
0
0
0
0
2
1
0
72 hour eye irritation score: 4.67
FORM 28-4
19WARF-IN
MADISON,
WISCONSIN
il[NCe
Sample:
T-1166
Eye Irritation:
(continued)-
WARP No. 5011023
Results:
Rabbit Number
1
7
2
days
3
Cornea Opacity Area
Iris
Conjunctivae Redness Chemosis Discharge
no noted irritation all readings negative
7 day eye irritation score: 0
FORM 2S-4