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AR226-2746 -^ Copies to: E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO. 128-68 MR NO Material Tested: Ammonium Perfluorooctanoate Material Submitted by; Plastics Department Fluorocarbons Division Haskell No.: O^ier Code: 5489 ACUTE ORAL TEST Procedure: The test material, as an aqueous solution (pH ~6), was administered by intragastric intu ChR-CD male rats in single doses. Survivor were sacrificed 14 days later. Results; Solution 7. 15 15 10 3 3 2 1 2 1.5 1 1 1 0.5 0.05 0.05 0.05 0.05 0.01 Dose mg/kg 2250 670 450 300 200 170 130 120 90 77 60 40 26 5.1 3.4 2.3 1.5 1.0 Mortality* D 1 d. D 2 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. S 14 d. Toxic Signs Lethal Doses; uncomfortable, chewing motions, polyuria, increased respiration rate and face-pawing on day of dosing; ac 2250 mg/kg shovel- nosing, and at 670 mg/kg slight salivation after dosing Nonlethal Doses: at 90 mg/kg and above, feces small and irregularlyshaped for 1-6 days after dosing; at 90 mg/kg and above, uncomfortable after dosing for 1-5 days; slight initial weight losses at 26 mg/kg and above for 1-2 days Controls Weight When Killed (g) Body Liver 275 310 313 362 349 347 319 352 317 403 380 346 374 350 329 354 352-377 17.85 16.30 17.50 25.10 19.25 24.62 16.00 24.78 16.15 21.70 19.00 17.40 18.54 15.60 15.89 17.48 15.09-18.89 * D ( ) d. = Found dead ( ) days after dosing; S - ( ) d. = Sacrificed ( ) days after dosing. Company Sanitized. Does no - 2 - Summary: Ammonium perfluorooctanoate is slightly toxic for the male rat when administered orally, it Dose (ALD) being 670 nig/kg of body weignt. This compound appears to cause liver enlargement in rats as low as 60-90 nig/kg. Based on clinical signs, it also acts as a gastrointestinal irritant. SBF/jch Date; June 13. 1963 Report by: Oral Toxic Q^^^ ^ Approved by: /f^" /f/i J.~^Tey C /X(ss^isistatnatn Company SaniitEzsd. Does not c