Document x5n9aV6gJxmqe0oJ0J5mRwv5g

; Paria si THO YEAR ORAL (DIET) TOXICITY / CARCINOGENICITY STUDY OF FLUOROCHEMICAL FC-143 IN RATS (RIKER Experiment No. 0281CRO012) VoLuwe 2 oF 4 ConpucteD DURING AeriL, 1981 - Mav, 1983 RIKER LABORATORIES, Inc. / 3M ConpANY ST. PauL, MinwesoTa 55144-1000 U.S.A. 00879 SToadniavriidauaeld MSaicrnoescoTpaibcolnatdediicraaslcopRiecsorDtbecranttiionnds) FEAR: To teirteGralLTisonrat-oGriceas,pnIriec, it0y Sad in ats Tae: 2 nFaaen:t Oeettesrs 781) 0Sc6rificedSeixn Fenetsrleesisagi (1 F143 0 ge Hcrfocrasic servations (contivee: fLrohitKeiked (senteri) Pissiietniry verss "escearliare,inedrifafluisae,timoanrkewdile oHott eeannaiinnde,, raitssinngplane of section SHheercsaimdeross, saterate "ste glands, ale Traeinf,ilSipnag Ctairsds,esfoweereRrorouwd, tBoeaBrte,wiStthoianchs,omSaull]LiInetse:tine Luge Intestine, iSaslaivrayryBSaldaedr,, Efroer.ks, Dury, avery Slane, Trachea, Keren, Tyrid, Pacres, aFante]hsehie:1051) 6Te0rmin SSaecnrtifFiecmeale Sra (1 F143 300 pp WacrePsacswiacrGBslearsattions: Later was, 3 a dia, right wiki, icrosHcropeimcl Gserationst Sinusoidal tas, corte, aild KiLeenrey ""ehlevpitcaanieervaalaiszlaattiioo,n,ssinitsail l, wild - islaetay aitration, vakolated, cl, Hsenptlacte alteration, basphisic, fal, wp ahsypeelrpalrastiinceanloidzulaetion, ald Nasir lant THiterastiwocnrstags, sido, ald fuincarrnys Bader oott ewaanriendg,, iissiinngg Trhaeinf,olSowaiinng tGiosds,osBowneereMarfreonnd, tSoplbeeen,witHheianr,noSrtoamacihn,tsS:al ntestine, Large Intestine fLoyrtn, NWheerease,seDnrtye,rc)P,itSiatlairvya,ryTrSahcahneda,,ETe.hea, Parathyrod, Esphages, Fsrpoijeest:Maatbe: azCROIZ suweioe 78 Pa: 8 29. 2 200680 SInctainvairdiuzse)d NSaicnrgalsecoTpaibclaatneddMiMcrrionsaclopRiecpoOrtbse(rcvoanttiionnused) Riker Laboratories, Toc. 30 FEMS: Tuo Year Oral Toricity-Oncogenicity Study in Rats Table: 2 beinal Fate: GNaesebkers105I)RATGeErSsiml SSeaxc:riFfeimcaele Group (5) FC-143 300 gp Macroscopic Dservations: Ranwery Shand Microksacroepniacl servations: Horta KLiidvneery Lug LFaysaesrtryNoBtelan(dsesenteric) RRurtaatihtyarrsyie "Laarsgse,ma5ss5,115015 d4 ecaa,, right aillai lobolar Lei inguinal. "lSoitnuseoxiadnailnede,ctawsiisas,ingcortex, waked ""PPoerltvailc saienneornaclliezaatriocne,l?alindiltrate, wile "Pfolrvteasllarbilaeacdrocpthapgerso,limfletraitdeosc,al,wiladile Hesorrhage, local areas, ile ""HFeimboersrahtaegneo,ns marked ~"Htoetenoenxsanined, sot in pase of section bTrhaeinF,ollSopiwnianlg Ctairsds,eesBonwereNarfroowu, Stpelebeen,wiHtehairnt,norSmtaolsacLhi,nitSsu:ll Intestine, Large Intestine, itary lagder, eras, Dury, Trachea, Thyroid, Esophagus, Pancreas, Salivary Slane, Eve. Fdintiea:albaebeesr:105I)E-T0e5r0s6imal SSaecxrifFiecmeale Groups ( 51 FEALAS 00 pp Nacrascopic servations: Watwiry Gland Ficroscipic Ghsarvations: Haeaarretnl Kidney LiLvregr Fasaary Bland Puanrcyreas Purathyroi "Susaeltlclanerdemlaasrs,m4ss1, 21.5caa,dirai,ghtJef wills willa. ""Sbiyneucsaoriddiaall efcitbarsoisai,s,cofrotceasl,, ostienria'te Myocarditis, chronic nonsuppurative focal, ~Dshirnoinniacl progressive nsbvopathy, winieal SFPoerltvailcaniemnruacllzeaatriocne,llairnkfeidltrate, ld ~Hesorrhage, local areas, oderate "Fbietnrcocaadrecnionnasns ""HTeaibneelraratDriosgehryp,lasaiian,imsloterate "lat exaained, net in plane of section PSrpoejceicets:Nuastber: 028100012 Sunarized 510 page: 18 293 00681 ISnudmimvairdiuzaeld MSaicnrgolsecoTpaibcalaantedMiicmraoslcopRiepcorDti.se(rcvoanttiioonuesc) F143: Tao YeaRrikOerralLaTbooxriactoirtiye-sG,ncoIpnec.nicity Stay in Rats Table: 2 fFartien:albNeaebesr:1091)0-T4e6r0a6inal SSuec:rifFiecmeale Group (5) FC-143 100 gon WierPoistcuopiitcarGyservations (continued): SUtaelriavsary Slang . ""Hleitreexnanined, missing "Cystic ghands, wild GTrhaeinf,olSlpoiwnianlg Ctoirsds,ueBsonweerMearfroouw,n tloebne,wiStthoienacnho,rmSawlalllimIinttse:stine, Large Intestine, Uricary Blagder, Aorta, Traches, Thyrold, Escohages, Lyesh Node Gaesenteric), Bye. Ffaitnea:l GNeaebkesrt1051)8-T0e6r0a7inal SSaec:rifFiecmeale Groups | 5) FE-14S 300 gon NacraPsictsupiitcarGyhservations: "Hass, 0.5 co dia. KicroAsrceonpailc servations: "Sinusoidal ectasia, cortes, irked : KEisdonoheayges N"Cohtroneixcasipnreadg,resmsiisvseinngeshropathy, winiaal Liver "HFeeplvaitzscystienevraacliuzoaltaitoino,n,awiniituiaflocal, wild Lung oury ""CVyasstc,ulaurnilaaitneerraallization, soderate PPiatruaitthayrryoid ""bKadtenmcawnined, wissing TTrharcheeiae ""NNoott eexzaanniinneedd,, wwiissssiinngg inary Bagger "Net examined, wissing The following Brain, Spiral tCiosrds,uesBorweereFarfroouwn,t tSoplbeemn,witHheiarnt,norSntaoluscLhi,nitSsw:all Intestine, Large Intestine, Aorta, Uteras, Kanary Gland, Lyn Node (aeserteric), Pancreas, Salivary Bland, Eve. Animal Naber: 16-0608 Sex Fesale Braupt ( 5) FE-145 300 gpa Fate: (eels 8) Fosse Dead WacroNsacsopaiacrysBelravnadtions: Microscopic Oiserations: KiEdrneey Large Intestine "Large Fira subcutanecas ass, 121 915 ca, on leit side. ""hpeetlviecxaniinneerda,limziastsiionng, aild "hat exanined, aissiog SPpreocjieecst: Naabter: 0281080012 Suamrized 518 Pe 110 294 00682 ISnudsimviirdiuzaelg RSaicnrgolsecoTpasbculaantedNiMcarmoslcopRiecpoDrtise(rcvoanttiionnused) FL-IA3: Tos YeaRrikDeeralLiToorxaitcoirtiye-sD,aceTgoecn.icity Study in fats Table: 2 AFraitaes:] (Mhaenedlesr:881)8-F0o6u8nd DeadSex: Female Group ( 5) FC-143 300 gp Wicrascopic Observations (continued): Lrg NLayssssahryModEleanCduesesteric) Farathyraie sSkaianl! Intestine "AHlavsecoallaarr swaicnerroaglhiazeast,iona,utiwidlodcal, wild lPaetriveaxsacnianleadr,saoinsascirlgear infiltrate, wild K"loatt eenxaanniinreedd,, mmiostsiinngplane of section "SlFaitbreoxnaniond, aissing TBhreainf,etlSopwiinnagl tGiasrds,aesBoesereMarfroouwn,d tSoplbeeen,witLhiivner,norHmeaalrt,linSittosw:sch, Urinary Bladder, Aorta, eras, Dury, Fitsitary, Trachea, Adrenal, Thyroid, Essphages, Pancreas, Salivary Blanc. rina] Naber: 1046S Se: Female roupt ( 5) FE-14S 300 pp Fate: (ek 105) Terminal Sacrifice MacrFoistcoepiitcarDyservations: Naraary Blase Microwsacroepniact Ghsarvatiars: Ltiivgeaery Lrg Rasniry Bland Patraartyhyroid PSiatbuiivtaaryryBlunt "iSsuaelldaasuss,s, 0.c8a cduiad,ia.possidly inflamed wilt cyst, perineal area. ""GCoarrtainciacl partorgoraehsys,ivebilnaetberroagla,ttayc,dermaitlee "PPoorrttaall bwinloencdculcetarprcoellilfeniantfiiolrtr,atiel,eald "perivascular soonclear infiltrate, wininal "FGiatlircatsadceesloen ""NToutbaelxaarnihnyepde,rpnloatsiai,n pblialnaeteroafl,secotdieornate "-hhadterecxmaanined, aissing bTrhaeinf,ollSpoiwnianlg Gtoirsds,eesBonweerNearfroouwn,d Stpolebeen,wiHtehairnt,norSmtaolwscLhi,niStws:all Intestine, Large Intestine, EUrrei.nary Blader, Rota, Uterus, Traches, Thyroid, Esophagus, Lys Node (aesenteric), Pancreas, PSrpoejceicets:NuRaabter: 02810012 Suonrized sti page: 131 295 COO0ES3 ISnutainviirdiuzae)d NSaicnrgolsecoTpaibclaatnedMiAcnirsoaslcopRiecpoOrbtse(rcvoanttiinounesd) FE-143: Tao YeaRrikOerralLaTbooxriactoirtiye-sO,ncsIgnecn.ici3t%y Staty in Rats Table: 2 SFaotie:l ONeasbteer:1001)6-4S6a5c0rificeSd ein eFexmtarleenisGroupt ( 5) FL-14T 30 por RazrosPciotpuiictarByservations: sun MieroNsacaanpsircy BBilsaenrdsations: hareral Kidney Liver Lang KBaasrcyary Bland Prathyroig Pituitary Skin ""RHaeirsrehdacgiirccumlasrs,in0f.1lacmae6ale.siss on Left reac "Rofuonudtgaads., 1 cn dia, dn inguinal ares. "SRiendsuloliadrayl ceelcltahsyap,erpcloarstieas,, wwinlldateral, wPhteesrcahtreoaccytons, malignant, wilateral Infiltration of segplastic tissue into "pseulrvircounsdiisnegralciozmaetcitoin,vewtiilssce. "PPoorrttaall sbinloenudculcetarprcoellilferiantfiiolntr,ataei,lewile Hepatocyte vacuolation, mili, aild ~Phearsicvualsacralwairnesraolniozsactlieoanr, winiflieltrate, wininal ""Taulbaucltaorcehlyeperplasia, bilateral, oderate "Not exanined, not in plane of section -hiesons "wpioldoatteerruaalt,itimsar,keudlcerative, hireles, Tbrhaeinf,olSlpoiwrianlg Ctoirsds,zesBonweerMearfroouwn,t Stpolebeen,wiHtehairct,neSrtsoamlaclhi,nitSswa:ll Intestise, Lurge Intestine, Urivary Slaceer, Serta, Stars, Triches, Thyraie, Esophagas, Lyset ce (sesenteric), Paccreas, Salivary Slart, Bre. frinal Mosse: 10-0651 Sex Fenale Groups ( 5) FE-143 00 gpa Fate: este 98) Sacrificed in extrenis MacrPoistcuopiitcarOyservations: KicroAscroepailc Oiservations: Esophagus fLaerge Intestine Liver "Raised wuss, 1.1 ce gia. "Sinusoidal ectasia, cortes, mild oat examined, aissitg h"Naott eexaasniioneesd,, wwiissssiiongg "Haelpdatocyte alteration, vacwolated, focal, SPrpoejceicets:MaRsaster: 028160012 Suanrizes sit pge: 12. 296 C0684 ISnudaimviirdiuzaeld RSaicnrgolsecoTpaibcslaatneddMiMcarionsacopRiscerOt.bse(rcvoanttiionnusrd) FEAT: Too YeaRrikOerralLaTboonriactoirtiye-sD,acoIgnce.nici3ty Stuty in Rats Table: 2 Ffnaitnea:l GMeoenrdosr: 9I8)R-0S6aScLiicedSexi: FeexmtarleenisGroups ( 5) FL-1004goTo Ficroscapic hservations (continued): OPraarraythyraid FiStaaliivtaarryyBland Tweiytraerity adder - diagnesis, imdeqate section "hot exauined, aissing ""hboeterecxaanines, aissing N"heott eexxaanmiinneedd,, saisssiing The following Brain, Sim] Ctoirsds,aesfowreereMafroruen,d tSoplbeees,witKhiidnneyn,ormHaelartL,imiLtusn:g, Stomach, Seal Intestine, horts, Uterus, Taseary Bland, Lyst ode (aesenteric), Pascreas, Trachea. fninal Mader: IR-USS Sex: Female Group (5) FE-1004g3p Fate: Gels 9) Sacrificed in extrenis PacrasPciotpuiictarsyervations: LiNvasesrary Bland Fierohsicrsesriacl Observations: KEisdcnpheiyges Liver Lung ""HAeIsKorrehsatgicinarsisg,htcibngudiiaal. ares, "Ale ""Shiontuseoxiadnailnede,ctaasiisas,incgortes, wile "Cironic progressive nevcgathy, ainisal "WHoerpcantsocclyetaer vcaeclulalaitnifcinl,tradt:ifofnu,se,sulntairieoscal, -Ppraerueanccnhiyaa,al,intneirlsetitial, chronic, mitifacal, Nastary last Pancreas Pituitary Spleen "bMitLhEincyssotrsnaolt Liinnciltusded wth section exavines. hina atrophy, nile "bdenons "Heucsiderosis, ail Tbhreainf,allSopniinanlg tCiosrsd,uesBowneereMafroruonwd tHoearbte,wiStthoirnchn,ormSaelalLinIinttse:stine, Large Intestine, Urinary Bladder, forta, Uterus, Dury, Trachea, Thyroid, Parathyroid, Lyash Kade (nesesteric), Salivary Bland, Ere. sPrpoejceicets:Maasther: 028100012 Smrizes st ges 138 297 00685 TSaentriroan RSRelosercoLTpocrlsaanereirefs,uiaTse.egr5st0ea(ttioinasl R15 To Yer (a Toasty apni Say 1 ats Tales 2 iFtl teeer 57S) FHou DeaSder Foal up (9) FEE 50 00 osecy BEseintions: Siallts,anasswesw,s 6s3i5l1 l2 sca i Int Keroscraeict serio: pry Simic tsa, cores, siete Giitgs SSepasianne,,asromiessvpritive fel, FuGnaeske Git FSraeirtaionbi,nlesdteetrnpirtea,iaav,e,wlfdoci, itd Press Fucratiton, orc, diffs, sere ETSnrivscnlSEienadtCnsftoerbteerheFaasfreo,dn,r9Syp,oben,FwiitKhtiigtnesrr,,aSTtwasnccht,hs:Souls,teriant,heurr,e Intestin, Gt aie samt), eivry i, Ee. FiantelNwaateer05BETTris SSerrifFceee Gro 51 C14 5p0 an Raroassrsyc OSeattions: abal.a wn 26 53 1 ca in pein) HerBaeoress Gseratins: SJoitnsiacnaa,ctmssicores, wg Key Gre FiPraorenacihcasprmevreesanivercse)ewie1fs4lt,rate5,4ile pForta tblevaatssprilei,ferwatiicnf, ,4144 Snialrtyy SSluts Ser SSFieamenintdias,,oicd, wtrate in ste at ernie, sissing riToatnensf,,aSluylnyoaw,GtoFarids,tetsToovnwee,eFTaarrasocndes,WtoiTboteeiiLta,ig,sPtraormcshe,L,iSenEisdabIanetses,tiLn,rLarRgoedentaessinte,errt [ rSpeaciees:aRart : CBG Samians sh pg101 0682968 Pancreas ~hcinar atrophy, eild sais ss 500339 Summarized Single Tabulated Animal Report (continued) Individual acRirkoesrcoLpaibcoraantoriMeisc,rosIcnoc,pic3O0bservations FLA1A3: Too Yar Oral Toxicity-Gncsqencity Study in Rats Table: 2 fFnaittea:l GMeaeakbesrs105I)R-4TEeSr9aimal SSeaxc:riFfeimcaele rowps (5) FC-143300 pp NieresSctaorpeisc Oservations (continued): "Fol TBhreainf,ollSopwiinanlg tCiorsds,uesonveereWafroruonnd, tSoplebeen,witHheianrt,norSmtaoluscLhi,nitSse:ll Intestine, Large Intestine, Urinary Bladder, Ovary, Pituitary, Trachea, Thircid, Parathyroid, Lysgh Node (nesenterss), Salivary Bland, ve. AFantiea:alhSeosmibeer:1051)6-T0e6r6a0inal SSeinrtifFiecmeale Groups | 51 FC-145 00 pon NacroPsictoupiitcarOyservations: "Hass, 0.6 ca dia. Raaniry Eling Ha2ss4,2205,x21leit3 cinn,gilmeflt.axilla; mass, 44 MicroAscroepiacl Bservations: "Sinusoidal ectasia, cortes, marked KEisodpnheaygus "lCohtraneixcaniporeosg,resasiisvseinngeshropathy, siniaal Pelvic sineralization, sinimal LiLavregre Intestine ""FNoerttoaldisaosniasn,uclceoalrecell infiltrate, ald Portal bile dict proliferation, ile - HCeypsattaoicdytdeegevnaecruastliaotni,on,focsatlt,ifnoicnailm,lairinal tung "Alvesiar acrophages, focal, wile LPyasasnharNyotBelan(dmesenteric) "Fpiibgreeanatt,enbornow, aild Fancreas "FIistlretaadceenllonscarcino PPiutruaitthayrroyi "-Nbodtenecxuaanined, not 18 plane of section Spleen "Heacsigerosis, wininal BTrhaeinf,ailSpoinrianlg Gtoirsds,ueBsonweerMearfroouwn,d Hteoarbte,wSittehnianckr,orSmaaallllinIinttse:stine, Urinary Blaser, Berta, Uterus, Dury, Trachea, Thyroid, Salivary Sland, Eye. Species: at Project Masher: 0281030012 Sumnrizet st page: 135 30c 0 G00688 SIundmiavriidzuaeld RSaicnrgolsecoTpaibculantdedMifcarioasa]copRiecpoDrtbse(rcvoanttiionnused) FLeIA3: Too YeaRrikedrraLaTbooxraitcoirtiye-sG,ncoIpnecn.ici3ty Study in Rats Table: 2 Fraitnea:] GMaedler:1051)8-0T6e6r1minal SSaec:riFfeimcaele Groups | 5) FE-143 S00 gon Mcrsscapic Observations: MicroEssctosphiacgesOservations: LKiigvneery Lrg Parathyroid -Xo visible Lesions. ""NDoitronxiacnipnreodg,rewsissisviengshrogathy, siniaal "FHoeeptaatlocyatoe cvalcweolraticoenl,l imnuiltlitfroactael,, wwiillde "Shlavsecoallaarr amsicnreorpahlaigzeast,ionm,itaiflodcal, nile "hot exsained, not in plane of section BTrhaeinf,allSoguiinnagl Ctoirsds,uesorweereNarfruonwd, tSoplbeeen,withheianrt,norSmtaolsaclhi,nitSsm:all Intestine, Large Intestine, ULryisnsahryNoBdead(eers,tntfeorritcs),,UtPearnucsr,easD,uarSya,liNvaasrsyarGylanGdl,andE,ye.Pituitary, Traches, birenal, Throid, minal Mester: 18-4662 Se Fesale Groups ( 5) FL-14Z 00 pp Fate: Geeks 109) Terminal Sicrifice FacroNsacaoapaircy hGslearnvdations: Miereascraapniacl Oservations: tEisdcspehaygis LiLvregr LKyaonshnaNoGdlean(daeseteric) Pituitary Spleen "Uicerated secrotic ass, 4x 3 ca, in right inguinal area. "Sisusaidal ectasia, corter, marked ""Cahtroneixcaspirneodg,resasiisvseingneAroathy, ald ""vhaosrctuallaransoinmaecalleiazratcieolnl, isniflidltrate, ald Heorrhage, multifocal, ald F"Fiitgreeasdte,robrnows, soderate denon "Hiersksetodpuiesis, extranedallary, increased, BTrhaeinf,olSlpoiwnianlg Ctoirsds,uesBonwearMearfroounn,d Hteoarbte, wSittohmianchn,ormSaelal]LinIinttse:stine, Large Intestine, Urinary Bladder, Aorta, Werus, Ovary, Traches, Thyroid, Parathyroid, Pascreas, Salivary Slant, Be. SPrpoejceicets:MaRsahter: 02010012 Sunnrined 54 ge: 17 501 000689 ISnutainvairdiuzaeld NSaicnrgolsecoTpaibcelaatnedMiMcrrionsalcopRiecporOtb.se(rcvoanttiionnused) FE-143: Tao YeaRrikerralLaTboorraitcoartiye-sO,ncaTgoecn,icity Study in Rats Table: 2 AFnaitaea:l GNeaebkesr:1051)04T6e8r3sinal SSeaxc:riFfeimcaele Groups ( 51 FL-143 30 poe NacresFcoapsicsBsEleirnveations: NicrohsecroepsiaclOservaticns: sdrecal Kidney Liver Lg Rosaes nBland : Hiss, 3 23 a, in the throat area. "Right adrenal appears sill. "Swiintursaoitdeal ectasia, sorter, unilateral, "DPherlavniiccspirnoegrraeliszsaitvieonn,ephirlopathy, wile "FHeerptaatlocwytoeonvcalseaalraticoenl,l sinuftiildtorcaatte,, maillee Hegatocyte alteration, vacuolated, focal, "Awlivleeolar acraghages, local areas, ald FHiebscrrarahatgeen,saild "Kot exanined, not in plane of section . The fellonizg Brain, Spiral tissues were fond Gord, Boe Narrca, to be thin norma Lints: Spleen, Heart, Stousch, Swill Intestine, Large Intestine, LUryiangahryNodBeatatgesre,ntfeorritcs),, UPtaenrcurse,asD,uaSray,livPairtyuiSthaarnyd,, TEryaec.hea, Thyroid, Esophagus, nina] Mondor? 10-065 Sec Female Groups (5) FEAIAS S00 pon Fate: (hashes 94) Sacridiced in extrenis MacrPoistcoupiitcarhyservations: MicrosPcaoapwiecryObSshearnvdations: seEsrcepnhaalgus Litoey Liver Larg FLyaanshnyNoSdlean(taesenteri) Ory PiStlueiteary ""RSaaiaslledwrieldh emrssst,pr1e.s2es0t.ia. ""Shiantuseoxiadnailnede,ctaasiisas,ingcortex, nile "DPierlevniiccapirmoegrraleiszsaitvieonn,eraoignaitahly, minieal "PPoorrttaall inolneacdlucetarprcoellilferiantfiiolntr,atwei,ldald "Hveassocrurlhaargew,ineloecaallizaatrieaosn,, wwiilldd ""Lhaottuleaxrampineerdp,lassisisai,ngaaderate "Tabular hrperplasia, aoderate "--bbdeesnoosnisderosis, aild PSrpoejceicets:Noastber: 0281CR012 sonrizes spe: 118 302 00690 SInudmimvairdiuzaeld SMaicnrgolsecoTpaibculaantdedMifcarinoaslcopRiepcorOtb.se(rcvoanttiionnused) Riker Liboratories, Inc. 3 FEIT: Too Year Oral Toxicity-Dicogenicity Study in Rats Table: 2 fFaitnea:l (Mhaensdiesrs98I)R-4S6a8cSridicedSexi:n Feexmtarleenisromps ( 5) FE-143 300 poe Kicrastcrsepriscs Observations (continued): hytronetra, moked The Fellowing Brae, Spiral tGiasrds,uesBoevereMarfroounn,d tHoeabrte,wiStthoinnicnho,rmSaalalLisIinttee:stine, Large Intestine, Urinary Slagder, birta, Trackes, Thyroid, Parathyreid, Pancreas, Sabivary Bland, Eve. fFraitsea:l WNaasssteer:105R) 0Te7reizat SSeaxc:riFfiaclee osgt (5) FC-LAD 300 pp RacrosPcietpuiictarsyervations: PicrasUcroipniacryBsBelravddaetrions: hEsecrpehaaglus Kidney Liver Lung Nanwaey Bland DPaurraythyroid Pituitary Salivary Gland inary Blaster ""RHaaillsedapmpesasr,s t1.h2ickaeneddia.. ""CNoorttiecxaalnioaetdr,ophayi,ssbiinlgateral, sodete "Pelvic "hortal asinnoenruaclliezaatriocne,llaiilndfiltrate, ald Portal Bile duct proliferation, wild "vFaesgcaulloacrytwoisnse,ralaiizladtion, wild Pwrielueacnia, interstitial, chronic, aultifocal, AHlevwecsrtrahragem,acrloopchaalgeasr,easl,ocaslodaeraeatse, soderte "GNroatncelxoannsi,nedm,itaiipslseing ""TNuobtuleaxranihnyepde,rplnaostiai,n ipllane of section "bimons ""ENpoittheexlaisailnedh,ypewrisslsaisniga, single, eiffuse, aild Hpertroghy, miscalaris, sil STrhaeinf,olSlpoiwnianlg Ctoirsds,ueBsonweerKeafroounn,d Stpolebeen,wiHtehairnt,noSrtmoanlscLhi,mitSse:all Intestine, Large Intestine, forts, Uteras, Trachea, Thyroic, Lah Node (vesenteric), Pancreas, Eye. PSrpoejceicets:Naabter: 0201086012 Suansrized 518 Page: 139 303 00691 ISnutaimvairdiezaeld MSaicnrgolsecoTpaibcalaantdedMiociraoaslcopRiecpoOrtise(rcvoanttiionnused) FU-LA3: Too YeaRrikeOrralLaTboorractiotryi-eDs,acoTgoce,ncity Study in fats Table: 2 AFoaitaea:l hNeoealbesrt B1116-0S6a3c8ridiceSdeidn eFexstarleenisGrout ( 5) FL-143 300 gon PacroPsictsupiitcarsyervations: Mersscopic Oservations: LSiavreenral Lung PPaarnaetehryroBildand PSiltueietary Thyreie rivary Bladder "Enlarged due to red mas, 1x 0.8 ca. ""SHiepmastooicdyatle evcacteasslaa,tiocno,rtpee,riwpiolrdtal, sederate "VHaesscourlrahragea,imrlaoclailzaatrieoans,, ##iilld N"hoatt xexaanniinneedd,, waiissssiinngg "-Hbedaeonsa:mdaerosis, wild ""hhaatt eexxaanniioneedd,, wwiissssiiorgg The folloning brain, Spinal tissaes were found Core, Bone Narrow, Ktiocabeey,wiHtehairnt,soSrtmoamlacLhi,mitSsw:all Intestine, Large Intestine, Rorta, Uterss, Dury, Traches, Escpragss, Lymph Mase (sesesteric), Pancreas, Salivary land, Eye. fFaitnea:l (Neoesitesr: 2I)R-4S6a1c0ridicedSexi:n eFexmtarleenisrust [ 5) FL-U4T 00 gon macroscspic Beervations: MicroPsictoupiitcarDyiserations: herenal vitney LiLuvrger PiRtauainatrayryBland Speer "Raised henorrhasic ass, 1 ce Cla. "SMienduusloliadraylceelc!tashiyap,erpcloartseisa,, wmiilltitoecdil,, swiizled "EPxerlovniiccapirnoegrraelsisziavteionn,esharoodpeartahtye, ald ""AFlivgeaselratr, aKcuprtoeprhacgeelsl,, fborcoawl,, wild ald Perivascalae sononclear iniltrate, winisal -badtencenxssnined, aissing "Hesositerasis, wild TBhreainf,ellSopniirnagl tGiosrsd,uesBoweereMarFroonwg, tHoearbte,wiStthoimcachn,ormSaelalLivIinttse:stine, Large Intestine, ULryisngahryNoBdlead(dseers,ntAeorritca,),ePraunscr,easD,urSya,liTvraarcyheGal,andT,hyrEoyiee., Parathyroid, Escghagss, PSrpoejceicets:MaRsahter: 0201080012 Saanarines 518 ge: 100 304 C00692 ISnuainvairdiuzaeld NSaicnrgolsecoTpaibcalaantdedMiAcnriomsacopRiecgrDt.bse{rcvoanttiionnasne) FO-1A3: Too YeaRrikOerralLaTboorxactiotryi-esD,icoIngce,nci3t%y Study in Rats Taste: 2 AFoaitaea:l (NMaebekesrt1051)0-0T6e7r2ainal SSeaxc:rifFiecmeale Geouss (5) FE-143 300 pou WacrasPcistpuiictarByaervations: Wicrohscroepeiacl Ohsernatioes: LEasrssyhagus oLyresyh Mote aesesteric) PiPtasriatthayrryoit Salivary lant TrThaycrhoeisd "Hasorrhagic mss, 0.5 8 tia. "Sinusoical sctasia, corter, animal ""Hleatscreexhaangien,ed,locaailssairnegas, aodeate ""TFuibguelenatr,hybpreorwpsl,assiia,niw]ailateral, ssserate -lbaeteraensaanine, wissing "Sialatesitis, chronic, aoderate ""lNaott eexaanviinneedd,, waiissssiinngg BThreainf,ollSopwirianlg tCiorsds,uesBonweereMarfroouwn,d Stpolebeen,witLhiivner,moKriadloeyl,iniHtesa:rt, Stoaach, Small Intestine, Large Tntestine, inary Blacer, forts, Uterus, Nasnary Eland, Pancreas, Eve. AFnaitoea:l WNeaeskbesrt 79I)R-SHaTcSrificeSdexi:n Female Graupt extrenis (5) FOALAS S00 pon PacrPaistcoupiitcarByhservations: Suin Micr[osrcopeic Dservations: Liver FLarngaary Slane PiPtauraitthayrryoid Thyreid ""LSaorbgceuthaenseonrsrshaagaiscseas,ss1,.511.511.511ca1 cdai,a. right anilla; 3.5131 2 cn let ail, ""PSoirntuasloidsaolnneacctlaesiaar,cceolrlteisn,fiwlitlrdate, ald "Pioarstcaallarbilseindeuacltizpartoiloind,erawtiilaer, aild "Adenccarcinon LBoatlaalcatrocheylpeerplasia, wederate aOrnees ooff tghaelagcrtoascsoleylsdeasncdribleodbulaaarssheyspewripslaas1ia. "hHeetroenxsanined, wissing "Hot examines, ising The folloning Brain, Spinal tissaes were found Cord, Bone Farrow, to be thin nora Limits: Splees, Kidney, Heart, Stouach, Small Intestine, LLayragseh bInotdeest(iensee,atUerriinca)r,y BPlaandcreera,s,huSratlsi,vaUrtyerSslsa,ne,OvaEryye,. Trachea, Esophagus, PSrpoejceicets:Maastter: 0281012 sonnrizet 518 page: 11 305 C00693 ISnudainvairdiuzaeld MSaicnrgolsecoTpaibculaanteedMiAcnraoasdcopRiecpoOrbtse(rcvoanttiinounesd) Riker Laboratories, Inc. 31 FL-143: Tuo Year Oral Toicity-Gncopenicity Stay in Rats Tate: 2 Animal Fate: OKloaebker:1051)04T6e7r5minal SSeaccriFfeimcaele Grup ( 51 FL-145 300 pe Macroscopic Bssrvations: Kistgney Nicros2cop)ic Observations: Sscahagas Heart Liivdenrey Lung Parathyroid Fitsitary -pparent areas of conselidation. "Soatat pale and pittec. "SCionrutsiociadlalvaeccutoalsaitai,on,corate1r, aoderite ""NMoytscaerxdaintiinse,d,chirsosniincgnonsgauTative, ~OLhorcaanlicarsearse,grewsilsdive mshrapathy, acherate "portal sononclear cell infiltrate, wild "NVeagsaclualcayrtossiimse,alaiiznaitniaoln, ail Branslon, diffuse, naried cLealrlgse. arFeeauoffraggruaennctlsonofwfiotrheiagannmagtiearnital "Norteseexcatn.ined, not in plane of section -hdencns The following brair, Spiral tissues were found Gort, fone Marrow, tSoplbeem,witShtionnaacohr,saSleall]iniItnst:estine Large Intestine, UPursicnraarays,BlaSdadleirv,arAyorltae,,UeErvues., Ovary, Famsary Slane, Trachea, Thyroid, Lysgh Kode tnesateric), dFaotien:al (oetshhe=rs105()RTTerTsina SSaecctrifFiacseale Graugt (51 FC-143 0gp MacroNsacnowpaircy DSilsaenrgvations: HicroHsacroepniacl Oservations: KiEdsonpehyagas Liver Lung aswse,lti2l5ebl1a5r cwaa,s,in6l.e5i1t a5n.i5l5las2 cu, in perineal area. "CSoirotuiscoaildalvacecwtlaastiiao,n,coirtlees, ile ""PNiogtueenxta,ninceodw,.atiasbs.ingepithelia, brows, "Psoirntianlalwononclear cell infiltrate, wsderate PRoergtaallocByitloessc,tainpiraoalliferation, suderate "Vascslar wineralization, wild PSrpoejceicets:aRbaetr: C21080012 Suanrized ST page: 12 306 00694 ISnutsimvairdiezseld MSaicnrgolsecoTpaibculaantdedMiMcarimoaslcopRiecporDto.se(rcvoanttiionnused) : FE-IA3: Tuo YeaRrikeOrralLaTbooriactiotryi-eDs,acoIngce.nci3ty Study in fats Table: 2 final Fate: Gaebtesr:105R)ATTe)rmin! SSeac:riFfeimcaele Beouss (5) FLALAS 00 gon MicrosLcyoep.icNDosdeerv(aatsieonntseri(ccrontinued: Ronse Shand DPuiaturiytary -"Sinusoidal ectasia, anderate "FFiibtrrooautdeennooun ""hTduebruclmasr agenom, wnilateral The follaving Brain, Spinal Ctoirsds,ueBsonveerMearfroouwn,d Stpolebeen,wiHtehairnt,sorSstaolmaclhi,aitSsw:all Intestine, Large Intestine, Urinary Blatder, Rota, Uterus, Trachea, Toyraid, Parathyroid, Pancreas, Salivary last, Ere. FAaetiea:alMKesebkesrs49()B-S4a6c7r8ificedSeixn eFxetnraelneisGroups ( 51 FC-145 00 pp Macroscopic Observations: NicrFoistcaupiitcarsyervations: Harenal LKiivdenrey tang Parathyroid SPpilteuietnary triniry Bader "Enlarged tue to mass, 130.7 ca ""Spienluvsiocidaailneercatlaisziaat,ionc,ortmeirl,d 14 fHoerptaatlocyatonesnvuaccluesalraticoenl,l lioncfailltraartees,,wsiille "Pvearsicvualsacratsairmrsaolrioznactlieoanr, iwniflieltrate, sil lHoettoerxrahmaignee,d,Loncoatl ianrepasl,aneaootfeastecetion H"ebwciseidnerosis, #118 "Not exanined, missing The faliouing Brain, Spinal Ctoirsds,uesfowreereFarfroouwn,d LHoeabrte,wiStthoisnacha,erSaeallaIintte:stine, Large Intestine, forts, eras, Ovary, Nasaary Glard, Trachea, Thyroid, Escphagus, Lysph Made (nesenteric), Paes, Salivary Blane, re. FAantien:al(bbeeetrst105I1R-TAe6rTa9inal SSaecxrifFiecmeale Sraust (5) FE-LES 0 gps MacrPoistcuopiitcarOyservations: Fasnary Bland "Raised "hatular bemsaosrs,rha1gicca agsisa,, 0i.n5 lceaft diadx.illas Large wass, 1 5 ca, in right inguinal area, SPpreocjieecst:Naastber: 0281080012 Sunarizes STAR Eois9s 07 TSduinvriidsule MSicsrgolsecoTnaiaclaatnedKiErnaaslcnBiecrOtor(vcanttiionanesd) FE: Tae YeaHrieOrralLoTroaitcoirtiye-sD,esIgcn.ici3t0y Std in ats Tate: 2 fFaota:l eWakseer10I) TTeraina SSueecriFfeimcaele Groups (5) FIAT 300 pn WicrosrcerniaclOharations (antined: iffoyus LLnegr oNuarnny Blast jFirsitary tte "Saritniscoaildalvaeccatatsiioa,n,cosrdteer,atseorte oMtaleexpahynpde,rplwaissiian,gcorter focal, adnate roratnale Bpirloegrfeascstivperolsiefterraatpiaotny,, amilries naurtioanlia, tersitial, dons, foal, PEevreisvlaasrclmacrroapnheangsc,iofnecailn,fwlialtde, ile FHietnrrraviavee,nlocal ares, moderate "aeaetnis perplasia, Bilateral, 4118 A"Ctyisstiecragrlaesisa,l aeirnsitnal ETreinf,oiSon0i0n)g otirstsesEnwereMarfroonnd, tSoplbeeen,thHeiart,norSmtaolmacLhi,neSse:al] Ttestine, Large Intestine, Eineet Batter, Kets, Trach, Paathyor, Lap ode (ssenteri), Puree, Salivary Sand, Fnaitea:lawsatsers1041) 4Fou0nd esdSex Female Groups 1 F145 30 pn RacroNseapaics slearnadtions: LiPvietrary Weroscroepniacl Busrations: htonrt tiLitrngeeyIntestine Gwivser Loss ode (asenteric) "arresae.msMsa,ks9a1d9s3ecr5o.8ticca,, in Left inginal uhrenrLheasisoinc, 0su.r4faccoe.di. Tle Sotimamsi]nede,ctawsiisas,incgarts, aid WoJoccaalriatriiss,, rwialene ronsgprative, oeltviscisniemr,aliaizsastiinng, sinissl Scnrsocsalsr,sciontrarlizlaotuiloanr,, wwilide ot exaine, sissing FSrpoejceicets:Nfaahtr: 02812 Sumrized Pg 0 308 00696 ISnudairviidzueadl RSaicnrgolsecoTpaabculaantedMiAcnriomsalcopRiecporOtbse(rcvoanttiionnuse) Riker Laboratories, Inc. 30 FE: Tuo Year ral Tosicity-Oncogenicity Study in fats Table: 2 RFaetae:l (Khaenette=r:100I)R-AFSoEu0nd DatSect Female Group: (5) FU-143 300 ppm Hicroscapic Oiservations (continued): Waany Eland PaOrratyhyrsic PiSteuliltaIrnytestine tera "LLyamrhgaengweilolsadricfofnerentiated tuscr with sunerces soterate to large size spices continirs fx "TIubuipltaorcyhtyepse.rplasia, werate "Net examined, not ia plane of section ""Kaoetereoxnasnined, wissing "Kot examined, missing TBhreainf,allSopniinnagl tissues were found Cord, Bone Marrow, to be within nora! Linits: Spleen, Stasach, Urinary Bladder, Aorta, Trachea, Thyroid, Escahigss, Facreas, Salivary Slant. Beinn Naber? SG-MSL Sens Female roupt | 1 FC-143 300 ppm Fate: Gieeks 97 Sacrificed in estreais MacroPsictoupiitcarOyhservationst Nicroscopis Observations: EsAorpehnaagles Kite LLiuvnegr Ovary FPaarnactrheyarssit Pituitary Slee "Heacrrhagic ass, 1.2 ca dia. "Sinussidal ctasia, corer, soderate ""pKeoltviecxanaiinneedr,aliwziastsiionng, sininsl "HPeeplaittoicsy,te avcuatce,atuinoinla,termaull,tifwoocdaelr,atseite "HViavsecoullaarr swaicsreorpahlaigzeast,ionf,ocaali,ldsinimal Ferivascular sononaclear infiltrate, sivisa! "HTeaabsurlrahraghey,pefropclaals,ia,wilsdoderate "Acimr atrsphy, aild "Ket exasined, fot in plane of section -Aenons ~Hesssiderosis, ald The fetloning tissuts were fount to be within normal Linits: Brain, Spinal Gord, Bune Marrow, Heart, Urinary Bladder, Rorta, Werus, Nasr 6Sltaonsda,ch,TraScehaelsl, ITnhtyersotiidn,e,LLyairhgeaIdnetes(tsiensee,nteric), Salivary Bland, Eye. PSrpoejceicets:Nahsabter: 028100012 Sunarized STAR Page; 15 30 0086: 7 SIunadmiavridiuzaeld MSaicnrgolsecoTpaibcalaantdedMifcirnoaslcopRiecpoBrtuar(vcoanttiionnused) FE-443: Tao YeaRrikOerralLaTboorxactaotryi-eDsn,csIgnecr,ici3ty Study in Rats Table: 2 rival Fate: MMeaeatbesrt 91)0-F0o8u2nd DeaSdex: Female Browpt ( 5) FE-143 300 pou WacrosNcaospniscrysGelravnadtions: Microhsicroepniacl Observations: EEseophagis Lirge Intestine Lurg PLaysaasahryNoBdleanatesesteric) Bary FiParractrehaysrsie PSiatluiivtaarryy Glare Sul Intestine Styornsiicch Urinary Batder Uterus -"Large wttilobalar ass, 11x 9x 6 ch in leit axilla, "hSaitnuseoxiadnailnede,ctaasiisas,ingcortes, marked N"hoott ecxaanniinneedd,, wwiissssiinngg "vBavsecsutlaarr aaiamcreoaplhiazgaetsi,oni,ltwiidlodcal, ile F"hiobtroeaxagneinnoend, wissing hat exanined, aissing ""Nhoott eexxaanniinneedd,, awiissssiinngg ""bliatenoemxaamined, aissing "hNaott eexxaanniinneedd,, waiissssiinngg N"Noott eexxaamniinneedd,, awiissssiinngg "lot essnived, aissing The felionirg Brain, Spinal tissues wre foun Cort, Bore Marrow, tSoplbeeen,witLhiivner,norKmiadlneyL,imiHtesa:rt, forts, Traches. Seal Kaaber: 10-0ET Sent Fesale Groups { 51 FE-145 00 gpa Fate: (asks 105) Tersiml Sicrifice MacroPsictoupiitcarOybservations: NicroHsicroepniacl Gservations: LiEsvoeprhages Lang P[arathyroid Pituitary "rass, 0.5 ca dia. "SAidneunsooniad,alcoercttiacsaila,, wciolratteesr,alsoderate ""hNaorttaelxasimooendu,cliesarincgell infiltrate, wild "BFroarnedilgonns,aatmeirtiiaflocianl,sorweilgdranslonss. "THaebauolrarrhaygep,erplolcaasliaa,reabsi,lataelrdal, soderate "tat exsained, rot in plane of section Hence PSpreocjieecst:NRoaatber: 0281080012 Suanarized STH Page: 16 31) . C00898 ISnuniuvairiuzaeld RSaicnrgalsecoTpaibculaantdedMiAcnrimoaslcopRiecporOtbse(rcvoanttiionnused) FE-143: Tao YeaRrikreralLaTboorraitcoirtiye-sG,ncalpiecn.ici1ty Study in Rats Table: 2 foil Naber: (RES Sex Female Groups ( 5) FLAAAS S00 pp Fate: Gets 105) Teraiml Sacrifice Nierescepic servations (continued): : BTrhaeinf,ollSopiwnianlg Gtoirsds,uesBenweerMearfroouwn,d Stpolebeen,wiKtihicneyn,ormHaelartl,inSittosu:ach, Sul] Intestine, Lirge Lyssh Intasting, Urinary Node eserteric), PBlaactdeesr,, ASoartlai,varUyteSrhuasr,d,NaEsraea.ry Gland, Trach, Thyrcic, rina] Naber: 1E-4684 Se: Fenale roups ( 5) FLA14S 300 gpa Fate: Geek 102) Found Beat PacrFsistcoupiitcarOyserations: "Raised, hessrrhagic, 0.1 ca tia. Microsrceopniacl Gsarvations: "hat exanined, wissing Essooprhtaagus lHaott eexxaaniinseedd,, wiissssiinngg Lung Lyaph Node (uesesteric) "laostceelxaasrinweidn,eamliissziantgio, aild Kasaary Slane et enanine, wissing FBaarrayttyroid ""NTeutbaleaxranihoyepde,rplwaissisai,ngwoderate . PSiatluiivtaarryy Bland ""hNoitmoenxsanined, wissing Tyrsie "Not eanined, wissin hTiradcehnetaidied Tissue ""LNoitgoenxanined aissizs Lsapregceifneicerdo.tic tor of atipase tissue, Site BTrhaeinf,olSlpoiwnianlg Ctoirsds,uesfonweerNearfroouwn,d Stpolebeen,wiLtihvienr,noHrimdalneyl,inHietasr:t, Stomch, Small Intestine, Lirge Intestive, Urinary Blader, Uters, Pancreas, Ere. FGartiev:el WNeaenkbsert751)8-S0a6c8r5ificedSexi:n eFxetmraelmeisGroups ( 5) FE-1AT 00pp MacroRsacsowpaircy OGblsaenrdvations: Microhsecroepniacl Oservations: rel "Lawrigteilmoabsesl,ar1,55 9x 4c sommetat fire ant "Both prared enlarged with dark foci. "Sinssial ectasia, corte, soderate SPpreocjieecst: NRoastter: 028108012 Summarized STAR Page: 147 31 1 00699 SInudmimvairdiuzaeld SMaicnrgolsecoTpaibculaantdedMiMcarinoaslcopRiepcorOtb.se(rcvoanttiionnuesd) FLAT: Too YeaRrikeBrealLaTbooxriactoirtiye-sD,acoIgnec,nici3t1y Study in Rats Table: 2 nFiatnea:! (Neaabtesr?751)R-4S6a8c5rificeSdexi:n FeexmtarleensGroups ( 5) FL-143 300 pou WicrasEcsuopphiacguOsbservations (continued): LKiivtneery Lang Nanary land SpSlaelievsary Blang -"lat exanined, aissing "hpeeclrvaisciss,nearialltiizfaotniaoln,, amlaerked "Hveausactaclsaroiessiinse,raelxitzartaimoend,ullwairlyd, ssderate AHlevxeoorlrahragea,croLopchaalgeasr,esf,ocaslo,fewriantieaal h"Faitbreoxaatneinnoends, aissing "lHeenstopsiesis, extrasedullary, increased, bTrhaeinf,olSlpoisnianlg Ctoirsts,aeBsorweerNearfroouwn,d Hteoarbte, wSittohmianchn,ormSaelallimIinttse:stine, Large Intestine, ULriitnharKyotBeadndeesre,ntReortiac),,UPtaenrcusr,easB,arEyy,e. Pituitary, Trachea, Thyroid, Parathyroid, Fiantea:l boebetesr:1051)R-T4e6r8a5inal Sess Female Sacrifice Sraupi ( 51 FC-145 00gpa PacroPsictoupiitcarsyervations: Panwary Blase Liver NicroHsacroepriacl Oservations: ELsitvpehragas tang FiNtauaniatrisrsFart "Saall "Large hletsiolrrohbaugliacraassss,,0.130 cxa7dxia.4 ca, in asrsig,htSaxnil3lac.a, in right lateral Ize, N"Seitnasecaindianlete,ctawsiisas,incgonten, ie "F[ artal bile 2a c: pride, w "PHaraitvitsazatearrtwieessc,leaeailn,fil6tr1ate, wininsl Heserriage, local areas, wid "Fiiebrrcaantaeroas "ca ietioning Brice, Spinal tse were found Gord, Boce Mareow, S15lebee ,wiKtihcioeeyn,orhmaelartn,itScso:uach, Suall Intestine, LLiyrgse KIondteest(ianees,ntUerriinca)r,y PBalnaccrteears,,fSoarltia,varUyterEulsa,nd,OuBryr, Traches, Thyroid, Farattyroie, SPpreocjieecst:Nuaattar: 028180012 Sumrized sti ogee 312 C00700 ISnudainvairdiuzael? MSiicnrgolsecoTpaibculrateedincriensacoRiecpsOeStse(rcaoanttiionnaset] FLAT: Tus YeaRrikeOrralLaTpornactiotryi-eDsa,ceIgnecn.ici3ty Study in Rats Table: 2 Reid Fate: GNeealtsert199S) UTeRraial SSaeccriFfeimcaele Bray (5) FC-143 09 par PacrFoistcaapiitcarByasrvations: Picroascroepiacl hservations: rent vitrey LPiarngcearyInGtleastnidne tary PiSitlueietnary ss, 0.9 cd ""Shiyneucsacridciatlis,ectcahsrioan,icconrotnesru,gpwuirladtive, "wChirtoinficoaplr,ogrsels6sive nphrogathy, wile "hNaetwateaxcainaisniesd,, acoilsosning "~Tbadbeunlcamra hyperplasia, doderate "Hescsiderosis, wile Tbrhaeinf,olSlpoiwrianlg Gtoirsts,uesBonveerNearfroouwc,t Ltiovebre,wLituhni,n Sntoorwmaaclh,LiSnwiatlsl: Intestine, Urinary Blaster, hurts, Sstaelrisvsa,ryTGrlaancdh,,yeT.hose, Parathyroi, Esophagus, Legh Node (aeseteric), Pancreas, doinal ater: (F450 Sout Female Grospt (5) FO-143 0 pa Fate: asia 165) Terinal Sacrifice Macrescopic Dservations: Wizrashceorepniacl Bhservations: does LiLvregr FLayrsasthhyNroodie Garseteric) Thyroid "Ho visible Lesions. "Sinusoidal ectasia, cortes, unilateral, "Drakroendic pr ogressive phrogathy, ail ""Vhaespcautloacrytienevarcaslailzaattiioons,,waelltdidocal, ail Preanonia, interstitial, chronic, maltifecal, Rwlivleeslar wacrophages, local aress, wile ""hPaitgaeenxta,ninberdo,n,notwiilnd plane of section "Wtiastranchial cyst bThreainf,allSopniinanlg tCiosrsd,aesJowneereMarfroounn,t LSoplbeer,witHheianrt,norSmtaolasclhi,teSm:all Intestine, Large Intestine, Urinary Bladder, Aorta, Urs, Duary, Rasaary Eland, Pituitary, Trache, Esophagus, Salivary Gland, Ere, Pancreas. PSrpoejceicets:WaRsahter: 0281R0012 Sanarizee STM Page: 169 313 00701 ISnudairviidzueals MSaicnrgolsecoTpaibcalaanteedMifcnrieoaslcopRiecporOtbse(rcvoanttiionnused) FO-443: Too YeaRrikreralLaTbooxriactoirtiye-sO,nceTqoecn,ici3t0y Staty in Rats Table: 2 Ffaitnea:l (Maeshker:100B)ASS9ac1rificeSdeai:n FeexmtarleecisGrog: (5) FC-143 300 pp Pacroscopic Bsarvations: Liver MicrospceorpeircalDservatioes: sarenal [= tigney LiLavrser fascress Sleer Stomach TUhryirnoairdy Fladder "Hpaeareeesn,targed With weltiple pale fact in "Left atrenal appears eslarged. "LSeirntuiscoaildalacaecettaastiiao,n,corltoecaxl, ress, aild nilateral, "wWayrskceasrditis, chrasic nerscgpurative, "wChirtoinfiecalpr,ogarelsesive neproathy, sisinal Frotein resaation droplets, tubular, marked ""VmaaslciuglraarntwiInyesrhaolniaza,tiAoins,tiwoiclydtic Faliguant Iysphona, histiocytic "HEedseonsr,rhaignet,erslioctailtiaalr,easa,csaeirlate "Hteamttopeoiesis, extramedullary, increased, "~HEytpoenrss,lassuibaa,scouacle,ll,woftoecraalt,e wild "Maliguant Iysghows, histiocytic The falioncsg tissaes were found to be thin normal Hits: NBraasiana,rySpBilnaanld, GoPridt,estBaornye, MaTrrraocnh,ea,SuPla]ratIhnytresotiidn,e,EsuLsahraggessI,nteLsyteicnhe,Nodfoertase,seUnhteerrsisc,),Dury, Seliviry Eland, Eye. final Nasbert IR-0633 Sect Female Groans ( 51 FL-LA3 00 gia Fate: Geeks 105) Terminal Sacrifice Macroscapic Otserations: + MicrPoistcuopiitcarsyervations: "bark raised lesion, 0.5 a ia. hiidrheneayl ""Spienluvsiocidsailrercatlaisziaat,ionc,ortweixl,d marked LLiinvger ""HPerpeautsoscayitae, viancteorlsattiitoina,l,slctiriednoicca,l,locmailtsareas, wld Alveolar aacrophages, local areas, wild Fitaitary bPeareinvasscalar soaclear infiltrate, aild PSrpoejceicets:Mafsahter: C2815R0912 Suarized STH Page: 190 314 00702 ISnduiviadunal NScirngolsecoTpaibculaantdedKiicnroaslcepFiecgaDrtBse(rcvoanttiionnesed FC: Tee YeaFrieGralLiTsoorsaitcetryi-est,hesfogce.ici3t0y Std in ats Tate: 2 RFeaitnea:] (Rhaeaeb:195I) RTeSrminal SSeac:riFfeiacaele Sous (5) F-10300 pn Fieroscoic servations (continued): BThreasf,etSopniinnalg Cboirsds,iesBonwterMearfroounn,d SLpolbeee,wiHtehairnt,rSatolnsclhi,niStse:al Intestine, Lire Intestine, LriytiaryReBelad(eaeers,tatheerritca),, UPtearnucsr,asD,rySa,bbvRaeroywalryanad,sdE,ve.Trachea, Thyroid, Parathyroid, Esophges, fFoavteea:l (Khoeeblesr:10I5)BATEeSrKainal SSeaxc:riFfeimcaele Group (5) FC-143 S00 pm MacrosFciotpuiictarOybservations: Nanny Slant Fizrowsicroeiacl Oseruaticns: Kidney Fuansgnry Shine tPuarraythyroid Fistislieteary i"Ssueldnmodsusl,ar1.l2esicoon,ia0.8 ca dia, in right ila posible wilk cyst. ""SCihnruasnoiicdaplroegcrteasssiiav,e nceoprrteep,atmhryk,esile "PAelvviecrainmearcarloipzhaatgieoss,,awtiinfitoaclal, sild "FCiybsrt,zataeirloanteal "eNontoenarings, net in plane of section "Hexssierasis, waderate TBhreainf,ollSoowian!g Gtoirses,cesBovweereMafroxn,d Ltcivebre,wiHtehairtn,nSotrommachL,iniStusa:ll Intestine, Lurge Intestine, Srailnivaa'ryBSadletr,, Eybei.rt, Weros, Traches, Thyroid, Estphagus, Lysh Node (eesenteric), Pascreas, Ffaiten:dWMeaesktser:10I5 ATeSrainal SSaec:rifFiecweale Groups (1 FECHA 00 pn RacrPoistcuaiptcarOysarations: Nawnary Eland FicrLoisvceoirc Dservations: hirenal idney HLeonbuotrahragciycstmicsss,s0,.84a5xdia3.x 20a, in left Maasls,la3..51312 ca, in nen lobe, "Swiinruesdoidal ecasia, corte, unilateral, "PDerlovincempirnoegrraeliszsaitvieonn,ghsrialpdathy, wild Psrpoejceicets:Naubter: C2BICRGR12 Sunarized STH Pages 151 315 C0703 . eSadngizeeds RSianlre eTbsuliatndReiriasdopeicrtQuessttiionnts) ker Lvrataries, Inc. 3% F103: To Yur Oral Tascity-rcgenicity Sty i fats Tate2: Foiitee tseekr1694) 5T5rea SSueritFiocuels Gras (9) F-10100 po Hifriaeo Bsrations cntinat): "psuarttaalcysteomaecoaanltcil,l iwnlftiiltfroactael, wwiillee Fwsos Elid sitwrtasty HyLcpogeererplialtseitsiioconnnowadttuhlhesxraemslieo,e cst Tribbarsouetdoanrs saci Imilirate, ainsi sGricmsccrucrciinnoonns arises i fibration. Ttayrereonstant, ait rTaheinf,eSlpoaln Liorsd,eovweeeMarfruonn,d Stpoebeen,wiHeirt,seStaelncLh,itS:eal Intestine Lure Intestine, LiiogeNeSetieesr,atforrite,DPrry,esT,achSau,barTyo1i,,PrEay.bror, Esha, oFaatets tNerre:1091) T6erai Saacsiedwee Egy (1 F103 00 on Hurospapirc Baration: ahiullalrsmwssi,lt5i1lna45u1ss,25 ca, it S301 2 cn in erin nd 0 igual WarLeeshDaeertaimoentse:r) irteel Liver rg a atic, S"Dionoiapraersetssaisv,e caoprotpsi,thwiyl,e ile HTepeastocryates,altweirladtion, viialaes, Reales, siniual rg Loh Kee tester Nor Sli riHiepvastocclytaeraltseraotiona, basionpfhiilliirci,te,focaail,inl YGrearthoang,, lTocoaull raeraess,, iwlld SBirnisotioana,l wascettues',ymrhet FHiibnroaatecrinoonns sPrpoieecst:Naabter: EBICHOLE Souarioed SH Pe: 12 316 00704 SInudainvairdiizaeld SBaicnrgolsecoTpaibculaantdedMifcarinoaslcopRiepcorOtb.se(rcvoanttiionnused) FAS: Too YeaRrikeeralLaTeorxaitcoirtiye-sG,nceIgneen,ici3t0y Staty ie Rats Table: 2 nina] Masher: 18-46% Sex: Female Group (5) FC-14Z 00 pou Fate: Gest 105) Terainl Sacrifice Hic[rosacapic Dservations (continued: PSiataulitaIrnytestine Thyreid -"Ost, wnitateral ""Shraenwulnons, esentery hyperplasia, cell, foal, wile The Following Brain, Spinal tissies ere fount Cord, Bone Marron, to be within normal Lisits: Spleen, Heart, Stousch, Large Intestine, Urinary Bladder, forta, ers, Trachea, Parathyroid, Esophagus, Parcreas, Salivary Blane, Eye. Grins! Masnert R497 Sea: Female Group (5) FC-143 300 poo Fate: ueete 109) Terainal Sacrifice Wacrascapic Gservations: PicreAscroepniacl Ohservaticns: HLiugngnwy FTihtyarieitdary ttarus "ko visible lesions. "Sinusoidal ectasia, Cortes, aoterate "fHaysdcroolnaursharianseirsa,liwzialtaitone,ralwild -bFteerisovniascalar soonsclear infiltrate, s13 "Hyperplasia, cell, focal, wile "Cystic glands, acderate The feiloning tissses were found to be within normal Limits: LBarragine,InStpeisntailneG,ardU,rinBaornye MBalrardoewr,, Sdpolretean,, DLiiavreyr,, Meaassra,rySStoawsisc,h,TrSawcehlels,InPtaersattihnyer,oid, Essphagas, Lytih Mote aesestericl, Paceas, Salivary lat, Eve. foiaal tert 16-0692 Sex: Female Graupt | 5) FLALAS 00 poe Fate: (hess 165) Terninal Sacrifice PasrFoistcuopiitcarsyervations: Nassary Blase Nicrosiconpeyic Dservations: Liver Lung ""hhsass,, 04.x5 c3a.5d1ia,3 ca, Jest inguinal, "Chrasic progressive nephropathy, wile "pPoerltvailc ssionneornaclliezaatriocn,ellaiilndfiltrate, sininal NHeegpaaltooccyyttoesivsa,cusoliantiinoln, multifocal, aild "Phearsicvualsacralmairwrsaoloinzaactlieoanr, ainlflidltrate, aild SPpreocjieecst: NRuastber: 0281880012 Sunrises 510 pages 155 317 00705 Souinreed MSioessTiedaatendRfATaEaREBIGterttiinees) F105: Ta YeirbGeaLaTrenacrhiyeSsc,apTnci,ci3t0y Std in ats nae 2 CFiiteel hXehe10T) Tsrina SSunrifFicoee ro {1 E18 0 0 WeshiancsOBgrnadtions cotinagt; oy itty -- ZTiuttsorwimieaasts, ere Hives Bhreinf,eSlooinn CtrsteEwsrerfeaed tSoylbees,witWheianrtroSrtsicih,ntSsal Ttetin, Large Itetis, ietnWeSeateesr tKiertrUerrae,e,TatSaasv,arMyrBah,,Tbotees, Prahrad, sos, FiiteNee58) Sidicet i vFeeei ro 9) FEAR 0 [ any -- Sd us, 3x2 cn in it with, Srrta Soiagrserpaoliswowsriatsie. Wreistte!r Oration: CRN rn Srimaoditl has, cartes, wiltera, ECotrtaictal drpemper,atisoinltweialla,treat,rmaerked weortts JrotoecianeswoitsisngTscal wes, ide rine TvwreisenapeWeess:tirn vyaneriiehde BJ aers Sn-- bfpi-- en PJarsd Sl sting "Saiatoina,aiTopeaa,iramrasis,tss mried en, id STtonrse S3eenvosris,tewnthiwere hFaeif,eSlionne tGosrsdyesoreeRaetodn tSoebenwitLhiinne,reclrelsitteosn, Uinry lsr, teres, Pitty Tuten, phe Fas, Sty Sid, rt sFpagoent: eart : zbcaotz Sanvstiszgee1s8 318 - 00706 SInudmimvairdiuzaeld MSaicnrgolsecoTpaibculaantdedMidcnrioasaclopRiecporsta.rv(caotnitionnuses) Riker Laboratories, Inc. FE-143: Tuo Year Oral Teicity-Dncogenicity Stay in Rats Table: 2 nFaitees:] (Neassbtesr:10B5-7T0e1rai SSeaxc:riFfeimcaele row: (5) FCAT T0C pe Macroscopic Observations: MicroPsictoupiitcarOybservations: Lihevreernal Lrg Prathyroid Pituitary "Henorehagic ass, 0.5 ca dia. ""Shienpuastcaicdyatle vecatcaasoilaa,tiocno,rtaes,itiwfielcdal, winieal Megalacytosis, sinial "APlrveeusstcanira,macirnotpehrasgteist,ialf,ale,reai,ld fecal, wild "Net xanined, not in plane of section -hrons The following tissses ere found to be within normal Linits: Srais, Spiral Cord, fore Marron, Spleen, Kitner, Heart, Stoaach, Seall Intestine, ELsicrpgheagIenst,estyiaoeh, NUortienar(yesBoltaedreirc,),arPtaas,creUatse,rusS,atiDvuarryy,ElNaansds,arEyyeS.lane, Trachea, Thyroid, fFnastuea:l WNeaekbeesr?811)8-0S0a0c2rificeSdexi:n Feexmtarleesisromps { 5) FO-143 300 pon MacrPoistcoepiitcarByservations: Waanary Eland NisrLosicveepric Ghsarvations: Epsecagrhtagas itney LiLvregr Nwarsnyary Slas PiPtaunicrteaarsy hedtish nass, 1.21 0.9 ce. "Laobnellaaterd raesgsi,on.3x 2x Lan, in leit "rattled n slightly ale. ""NMectcaeratsiitniesd,, Saoinssiicngnonsuppurative, ~wEihrtainfiozcaplr,ogwrielsdsive nphrogathy, winieal PPerlevliictisa,inearcaultiez,atwiiolna,tesrianli,salsild ""HVeapsactoolcayrtewivniecrawlliaztaitoino,n,pewriilpdortal, saderate hHoeesncrcrehaargcei,nomnultidocal, wild "Tabular hyperplasia, soderate ""Hhotenoenxaanined, assing TBrhaeinf,olSlpoiwrianlg Ctoirsds,ueBsonweerNearfroouwn,t to be within normal lisits: Spleen, Stosach, Saal) Intestine, Lurge Intestine, SUarliinvaarryyBSllaadndte,r,rAeo.rta, Uterus, Traches, Kirenal, Thyroid, Parathyroid, Lys Node (vesenteric), SPrpoejceicets:MaRsahter: 0281CR012 suanarizes se pages 155 319) C00707 SInudainvairdiuzaelg RSaicnrgolsecoTpaibculaantdedMifcariuoaslcopRiepcorOtb.se(rcvoantiioounesd) Riker Laboratories, Inc. F143: Tao Year Oral Toicity-Dnesgenicity Stady in Rats Table: 2 fFnaittea:l GNeaesskesr:10[9-4T1e6r5min! SSeaxc:riFfeincaele Grow: (3) FC-143 300 ppm Racrascapic Oservaticas: MicrosTcaoewpiircy OShisaezrdmaticns: Ehsicorbea]gis Heart Litvheery Leng Kanwar Gland PPaistcurietaasry "Latelar mss, 33 2c, in perineal ares, "hSaitnuseosiadnailnede,ctamsiisas,ingcortes, warted "Hwyistciafrodciattis,, wDilreone novsapative, "Chronic progressive neghregathy, wild "HHeegsaattooccyyttee avlatcesrlaattiioonr,,vamcuwlotliaftoecta,l,wlwtiniifteaclal, wile "Parleduacnia, interstitial, chronic, focal aress, "lRolbvuesllaarrhwyapcerropglhaasgieas, local areas, wile ""Hkypeenrcpnlsasia, islet cell, ail The falloning tissues were found Le be within moral limits: Urraiinna,rySBpliandaelerC,ordf,atoar,eUtFearrcrso,w,OvSaprlye,en,TraScthoewsa,ch,ThySrwoaildl, IPnatreastthiynreo,idL,argLeyiIhntMeosdteine(,sesetericl, Salivary Bland, Bre. final Kanter: IR005 Sex Fenale Becupt (5) FE-IAS 00 gan Fate: thesis 6) Found ead Pacrascosic Bservations: Pitsitary MicrEossccpophiacquOssarvations: HeEanrt Liver LSualgivary Slant inary Bladder "Tolocsuaalltiae.ssrrhagic lesions approxinately hlaott eexxasnainiende, aaiissssiinngg "Myocarditis, chronic nonsugpurative, "hweiptatiofcoytae,vaacludclation, waitidecal, ail "iRaesgcaulloasrytroisnsr,alaiiznaitmiaoln, ail dot eanines, missing "Not amine, aissisg SThpeinaflollCoowrdi,ngBtoivsesuMrasrrowwe,reSftooumnadch,toSbeeallwitIhnitnesntoirnaea,lLalrignietsI:ntestine, forta, Uterus, Dury, Wansary Gland, Pituitary, Trachea, Adrenal, Thyroid, Parathyroid, Lysh Note (aesenteric), FSPpreocjieecst:MRaasther: 0281R012 Sunn stat page: 186 320 00708 Sori StfilotiTsbiotalHibonareBotrSoctonttion) FA: Te Ye Bak rico St it ts ie: 2 a i eTooe Gy 3 FE 0 Pheeo[ nnbyahieew-- Kifme 1 abi ae Hats cto' f--_rrip-- Sanipcgo157 321 G00709 InfiviSeuulaiRaTntoRSiIsCleiTniaRletreasdcoipinclBiswausrtions F103: Teo TekweGralLitToenaiyta-rGivcs,apImnci,ity Stat in Fats Tate: 2 iFintea taebher1085)3T0r6an SSuertifailcee runs 6) EAI 30 pn MarLieers Bsration: Woroocitic Gsaratios: npoeews Pwrscras TSrlady Elise ".ossivly ale, satin, Whesccawrittails,ivrosoinss, nmintesratine, wld rSFonrtail ssraocrsleievecoolnismielrnateH,l:wile Ffoerat tbislevdaccotlapteiaolni,ertatiifono,ali,lsnim ipiece alteration, acetates, cl, J"ost lnaaiosein,eraaitsisnitnigon, ile hSpiaelsattaistai,s, ccreoln,focrail,edwile lThaersf,ollTeoswtsisisasihudensaiwsa,e rfaosutsatteo,bSetwointchhi,n aIrrnaary LBiliatsi:n, Kress, Faatoyrai, Trane, Capa, Pitty. Fiatnesa tNeaesser107 ) SidesSe1x eMarleesGroat (6) F530 gn WavosstsactrByaation: sar HicrSotsocpnceBaeratisns: ort itwy jtrw ittissitary ston faaiisseed hulcoerratead cLeesio,ns 0o.n8bcaothdhii.ng "oastsbtlse.aes of lceratis is aria. "wbitciodcl,, aclrdaic somgpurtine, "Preitectpmrrogariesssaitvoens,epsritiethy, write o"rstc,aaeinnoenrcalieanticoenl,iailltdrate, wild cHealrraiger,iisiusf,,a1i4f, ald Sforteotmrntits, ulcerative, bilateral, aed er, ried Testis/Epidiynis ~TVaabuclle ratrsoipnheyr,liansspteirosna,toge1n6esis, ail SPrpaigecst:Naakte: QIERUIZ Sawrizet 50 ge 158 322 00710 SInctainvairdiuzaeld RSaicnrgolsecoTpaibcalaantdedMiAcnrimoaslcopRiecpoOrtbse(rcvoanttiionnesnd) Fiber Lisorateries, Inc, 0 FE-IA3: Tuo Year ral Toicity-Dncsgenicity Study in Rats Tate: 2 fFaitnea:l MNeassbher:1011)53S6a0c7rificedSeicn MxatlreenisGrow (8) FCAT 30 pon Microscopic Dservations (continue): Urinary Hager "Eritheliat hyperslasia, siwle, diffuse, ale lEopciatlhealrieaals,pewriplldasia, papillary, Calculus Ihe following tissues were fac to be within sere Hts: Spleen, Prostate, Arent, Thyroid, Parathyoie, Traches, Escphases, Salivary Sad, Pancreas. SFeaitnea:d Oaenldeer?8I)RSIac8rificedSei:n MeaxlternisGrow ( 8) FC-IAT 30 pon Macroscopic Rservations: Ths SLpilveeern Crash Note abgaaioal) MicrKoistconpeiyc servations: Liver Lary PLaysacprheasNote abscninal} siPitteuitary Toyess "Lotbhuluasteta,real,ight-green wiss, 2.5 1 1 ca, in ""EProlsasrigbel!y slightly pale. enenala,rgeidntaenrdnalLigihltiacgreIeyngihshniontecsolsalri.ghtly "Leukenia, ayeloid PErxotteenisnivreesionrfpitlitornatdiroonpleofts,proillieferating cells "Loefsteenairal,y aapyeellooiitd series ie hilus. "Lestenis, yeloid "HLeeasokrernhiaag,e,apemluolitidfocal, wile hat esanined, aissing N"Loetskeenxiaan,inescy,eloiisdting "Leskenia, yeloid The following tissues wre found to be within rarmal Linits: THreaacrhte,a,TeEsstoisphEapgiudsi,dySaailsi,varPyrolstaantee., Stoaach, Urivary Elater, birenal, Thircid, Parathyroic, PSrpoegceicets:Nuastber: 0281080012 Suanized STA page: 159 323 00711 ISnutnimvairdiuzael SWiCsPgOlSeCTObBuclaatndedWiicmraoslcepRiecporOtbse(rcvoanttiionnused) FEAT: Ten YeabrikBeralLaTboorriactoirtiye-sD,acoTgoecn.ici3t0y Study in Rats Table: 2 FAantiem:al(Neoakteer:108R) 3Te9raimal SSaec:rifailcee row: (8) FC-IAT 30 pom Wacrascepic Observations: Ficrsscopic Dservations: hiidrneeryal Paannycreas Pituitary TShaylrioviadry Bland ) 4b visible lesions. "~NCehcruatnliacryprcoeglrlesWspiveergnleagsnirao,patwhyl,ia1o1, wild "~ibaescnaelaratwreiznheyr,aliwzialtdion, il H"ySpiaelrapdleansiitai,s,aecthriofnoicca,l,otpearrastedistalis, wile "UHpletrisalsarsairas,halceclyls,t mltifocal, saderate The fatlonizg tissues were found to be within moreal Hits: STirlaecehne,a,LiEvsesre,hasHiesa,rt, Testis/Epididyeis, Prostate, Stonach, Urinary Blaster, Parathyroid, fecal Fate: ONeaiactser:108I)E-TTeEr0ainl SSaecctrifMiaclee Groups (6) FE-1A3 30 pp Fazrascopic Observations: Nicreasacroepniacl Qservations: Kidney Liver Luss parcress Sativary Slang Ko visible Lesions. "CPohretcicchaelonsdceygteonnesr,atimoanl,ignfaenctal,, aaioldaetreartsel . "ChMreasnpilcastpircogrceeislssivehignhslbyvopplaetohcyor,phsioct.erate "FNoerctraolsiss,orofnoaccalle,araicneilnlalinfiltrate, si2 "Hhlavsecsullaarr wwaicnreorpahlaigzeast,ionw,itwiifloecal, wild "bSciiarlaadrenaittriosp,hy,chrsoondiecr,atmearked he folloning tissses were fount to be within nerral linits: STpriaecetse,a,HeEasrotp,hagTuess,tisPiEtpuiidtiardya.is, Prostate, Stove, Urinary Blatter, Thyrcid, Parathyra:d, PSrpoejceicets:MaFsaster: O281CR012 Suirizes STAR Page: 160 324 00712 ISnudinvirdeuadl RSiatre eTcslaitnescirnalsBsersteacamttiioonnst) F-403: To Yekre0raLeTresscainteys-D,rcngte,ncity Std i Rat Tate: 2 Ffitue tNhaesner108E) TEras SSuerfHaaclee rugs C6) FE 30 po [rioyw: -- "Kilis cst is ane arn of right bien. rel fweortbs Hers lier Ptages Fsitry "tSoirntuiarltlvcsoleattsio,n,Corltoecsa, iarEes, ild hoteradnsne,,cirsaiincgrowsgrative, sini "PDeolvniiccaesraeisrateions, paantale, Motte aOpt,accoertivcaal,cawtlitiosnlewitifcal, wile apiate alteration, ecalates foc aMeslscytowinse,raliinnitnilcs, ald Hpeerptliasna,sfsoic,siprs dstalis Th flionng sss wre dn ts be ith mre Linda: Siwy Sard, Spleen, Testis/Eziciconis, Prostate, Stomach, Urinary Bladder, Thyroid, Parathyroid, Traches, FBiined tNhaiete9035Sc2ificedSu1t ralee nSeon (1 FOE 0500 WariteisarByaration: Sant Hcroesrcemriacl Gswrations: tidiorny TM FPiatsuittaery STstriuaeinht inuy Baer LSiastiagnpdeoarstotwheisc,ken1s.2 acammctino.nss paste lee in area. ""Coorltuitnaiovnssloamti.ont,it.wiwtiitfheeaolk,s wnldial SHoeratatsbtieleadoclt artaiolne,rsfiiotrs,,imtiele "vsetelr nianceraatbiaaetsi,onw,tiadleacal, wile Frraostantitis, wate, wete eiHeprvro,ssiitwearikoasdi, wild cll, mitifaal, ile "arteiial brerlasi, sil, dius, ald PSroojsec:t aadte: 20108012 Surizet SW ge 16 325 00713 SImncairviizdaeld RSainrgolsecoTpaibcalaantdedMincirnosacopfiecporOtser{cvoanttiiovnaesd) FE-143: Tuo YeaRrikOerralLaTboornactiotryi-eOsn,coIgnecn.ici3t%y Study in Rats Table: 2 AFratiea:l Oaebleer:90()63S6a5c2rificeSdexi:n MeaxlterenisGrout ( 6) FC-141 30 pon Hicroscepic Bservations Continued): 3 HTehaertf,olTloweingsatittsfsisietsvsses,rePfaoruanthtoab,e wTriatchhiena,rorSmsaslshalsiessi,ts:Salivary Eland, Parcreas. fron! Neatart IB3E53 Sex Male Broust {61 FCAIAT 30 poe Fate: (esis 108) Tareina: Sacrifice Pisrascipic Gseevitions: WicroTsecsetsiis: EDrsiecrivdamtiiosns: idrey tong Testis Epidityais "Right testis small. ~Earasic progressive nephropathy, ei2 "Hveassocrurlhaargem,imleorcaallzaatrieoans,, saolteeate "wTurkkselte atrophy, aspernatogerests, snilateral, STshleeefno,llLoiwvienrg, tHiesasrute,s Pwreorsetaftoeu,ndSttoonbieh,wiUtrhiinnarryorFeallattteirn,tsh:icenal, Thyraid, Parathyroid, Teaches, Essphasus, Salivry Bland, Pitiatary, Pancreas. frinal Noches RTE Send Male Grog: (8) FC-14S 30 pon Fate: teste 105) Terainal Sacrifice MacroFsrcaoipnic Bservations: WicrsAscroepailc hservations: rain Heart Kithey Liver Lung "park area, possibly ald heacrrhage, is Daenatiesrpihoerrep.art of right cerebral "Simsoidal ectasia, corte, scterate "hPrsetsrcoacryotnocmc,ytobnesn,ignbeniga, bilateral "MLyuorcgaerdinteissp,lascehroocnciucpynionngswspcurhatoifvec,eresros. "wDialvteznhioccaplr,ogwrielsdsive nesNrgzathy, eile "Pheelpvaitcacayitneeraalltiezraattiioorn,, svaecuaoltated, focal, wile Begalacytosis, wininal "Paesacnia, interstitial, chronic, aaitifesal, aRllveeclar aacreshages, mltifocal, ald SPpreocjieecst:MRuastter: 0281080012 Saanarized S18 ges 12 326 00714 ISneainvairdiuzaeld aScirngolsecsTsaibculaantdedMihcirmosacopRiacparOtbse(rcvaanttiinocnesd) Fe: Too YeaRrikOerralLbToorvaitcoirtiye-sD,ncoIgnecn.ici3ty Study in Rats Table: 2 fFraittea:l (Mhgebsesrt108()RTEerLainal SSaeccriMfailcee Brows (6) FCT 30 gpa MicrosFsaonpcirceasCservation (contiesed: Parathyraic ~-Hcinar atroghy, soderate "lot examinee, nat in Slane of section The fotloning tissues were Sle, TestislEpididyns, fount to be within Prostate, Stomach, nUorrimnaalry llinaistdse:r, Thyroid, Trachea, Esopnagus, Salivary Bland, Pituitary. frsual Naaber: IR3655 Sex ale Grows ( 6) FE-I4T 30 pon Fate: Oske 108) Terminal Sacrifice MacroSsocfotpicTisOsbuseesrvaetciokn)s: Testio/Eratidynis Micrshsearoepniacl Oservations: Kataey Lary TSeasltiivsarEypilgaienntnis ""MRaisgsh,t 4test2is5ela2rgcead,,saplailvearyyelglloannsdhar1e.a5,ca dia. ass. ""CCohrrtoinciacl prvocgarselsastiivoer,nefpehcraclg,athwyi,ld sscerite aPseclvaiicarsinperaelriazlaitniaotni,on,sitweile "ASlivdeloaldaeritmiasc,ropwhaatgee,s, local waked ares, acterate "Tudule atrophy, spermatogenesis, unilateral, Lwedyetriastecel] adenoma, unilateral STirelafso,ilLoixviecry, tHiesasrete,s Pwrroestafteo,uSttoonbaet,wiUtrhiinnaraycrmBallattLeirm,itTsh:yrsid, Parathyroid, Trachea, Essphagss, Pituitary, Pancreas. frinel Mater: B36S6 Sex: Male row ( 8) FEIT 0 gon Fate: tasks 851 Sacrificed in extrenis MacrPoistcsopiitcarDyservations: Wicrobscroepnict Qesernations: LKiidvneery Lung "Large mass, 1107 ca dia. "Cortical viushation, focal, wile ~CShirnaunsiocidaplrogercetsassiivae, nceogrhtreoxp,atahiy1, winieal ""hHaesscaotloacrytaeinvearcasloilzaattiiono,n,iafiiluse, sederate Heworrhage, witifocal, wil PSpreocjieecst:Mofnadtor: 0R0012 Suewarized ST ges 15 327 . 0715 SInuniavriidzuaeld MSaicnrgolsecoTpaibcolaantdedWiMcrrinoaslcapRiecporOtbse(rcvoanttiionnused) Riker Laboratories, rc. FE-143: Tao Year Oral Toncity-Gncogenicity Study in Rats Tale: 2 SFaitoea:] GNoaaabtesrt 89I)E3S6a5c8rificeSdeixn Meatlreesisrout ( 6) FC-1AS 30 pon Wierascopic Bservations (ontinaed: FiPutrsaitthayrryose Salivary Blan Hbaeteenxamined, not in plan of section "Net exanines, wissing STphieerfse,tlHoesicr=tg, tTiessstuiess/Ewgeirdeidfyoauinsd, tPorobsetawtiet,hiSntocnriceha, ULriimniatrsy: Bladder, Thyroid, Traches, Escitas, ances. Ffiitee:dfNheoskmse5)10S3a6c7rificedSeixn eMxalterensSeoupt | 6) FERIA 30 pan Facroscepic Dhservations: WicrFuistcaopsitcarSyheervations: Heart LiJveer FiPtanacirteaasry Salivary Slant "Enlarged, 0.8 ca dia. "Myacarditis, chronic povsspprative, focal, "Pwotretralatesnonsclear cell infiltrate, wild lHaisvecsdlaarr msaicnreoaplhiangaest,ionm,itsiidlodcal, ile hHeesiornrhaagter,ophlyo,calaianriemals, il ~henona "Not exanines, aissing TShseleefns,lloKniidnngey,tisTsessetsisw/eErpeidfiocuynads,toPbreostwaitteh,inSstoowrscah,LUiriitnsa:ry Bladder, renal, Thode, Firatiyroid, Trach, Esophags. Ffartien:al WNeasbieer:108R)3T6er8minal SSacerifailcee row (6) FEIT T0 pon Macroscopic Oservations: MicroEsrceopic Qservations: KEirdeney Liver Lung "Right eye appears clout. ""tDehraatniitisp,rargroessiseiv,e wniplraotpeartahty,,nialled "hepatocyte alteration, vacsslates, sultifecal, Mwaigladlocytosis, sini "Asicvaesllaarr ssaicnreorpahlaignetsi,osm,ultaiidlodcal, wild SPpreocjieecst: NRsabter: 0281280012 sarin sti ge: 14 328 00716 SInucnimvairdiuzaeld MSaicnrgolsecoTpaibcalaantdedMiAcnrionsaclopRiecpoOrstse(rcvoanttiionnased) Riker Liboratories, Inc. 30 FE-143: Tuo Year Oral Toicity-Dncogenicity Stuty in Rats Table: 2 MFaitel: (aebcoasrt106R! 3Te5rainal SSeaxc:rifKiaclee Grows: ( 6) FOIA 30 pon Wicras[cepRiceBhservations continued): Thyraie :"Gist, pars distalis "hyperplasia, cell, focal, moderate he follenics tissues vere found to be within normal Linits: TSprlaecetre,s,HeEssestg,haTgeess,tisSaElpiivdairdyyaliasn,e,ProPsatnarteei,s.Stomach, Urinary Blader, Adrenal, Parathyroid, Arinal Mosher: S350 Sex Male Group ( 8) FEIT30ppm Fate: Gesle 91 Sarificed in extremis MacroPsictsugiitcarOybservations: MicrLosicvoepric Diservations: hirenat Kidney Liver LiFnugrathyreid PiStlueietary Testis/Essdidyais "Large Sesorrhagic mass, LA x 0.8 ca. "Fale and settled, "CSoirntuiscoaildalvaceusotlaastiiao,n,Cordtiefsf,usew,iliele "CPherdaincicmpnreargarleiszsaitvieonn,eshmraorgkaetdhy, wil "PFoorrttaall sbielneondculcetarprcoellilferiantfiiolntr,atwei,ldwile Hepatacyte vacuolation, periportal, sotrate ""hveatsceuxlaamrinweidn,ernaoltizaitniopnl,anewiolfe sctice ""Hbeinssonderusis, 4i3 escular einesalization, wile THheeartf,allBoreoisntgatet,issSuteosascwhe,reUfroiunnadrytcBlbaeddewri,thiTnhyrsaasrm,l Tlraicihtess:, Sscshages, Salivary Slard, Parcreas. Ffarties:al Waaetieer:1081)03T6e8r0sial SSierxifailcee Geeust | 6) FO-1A3 30 pp Macroscopic Dservations: Microscopic Oservations: Hiheraerntal Kidney Liner Ho visible Lesions. ""SHiyneucsaoritdiatlis,sctcahsrioan,icconretnessu,gpawrialtdive, "wCihtroindioccaplr,ogwrielsdsive neshropathy, ail "fFaorrttaall obniloevedculcetarprcoellilferiantdiiolntr,atsei,ldald PSrpoejceicets:Nafsaster: 028108012 Somnrizee S10 Fuge: 165 329 C0717 ISnudainvairdiuzaeld MSaicnrgolsecoTpaibcula11t6edMiMcironstcopRiecpoCrotse(rcvoanttiionnused FEA: To YeaRrikebrralLaTsorxactietryie-sD,cogIenen.ici0ty Stacy in Rats Tables 2 fFiatnea:l hKeeatrs:1016)34Te8r0aimal SSaecsriMfailcee Group {8 FC-143 30 pe Ric[rotscypic Baervations (continued): TFhayrraotihdyoid ": weal sineralization, alld PArlevuesaaleaira,waicrnotpehrasgteist,ialw,iicthidaoaciacl,, faoiciadl, wild "hatcelelxanaidneeodn,s,matuniirlatpelraanl of section tistranchal erst STpileefne,tToensitnigstEipisdeiecsunwiesr,e Pfroonsetatteo, bSetowwiatchhi,n UerrimnaalryiBnliatdse:r, Trachea, Esophazus, Salivary Sad, Pituitary, Pacreas, Fraiten:atNeoesse108R)4T6er1minal SSaecxrifMiaclee Grau (6) FCS 30 3p Ficroscpic Osernations: Ficraorscesaics servations: heart KiLrdgeey Sitivary Sint e visisle lesions. ""CHocratricdailtivsa,cslchartoinoinc, wfsupla,twiivlde, "wCihtrniidcocrae,grweislsdive neshgathy, 14 "Sitaalsaederitsiise,raethirzaastiico,n,al#d126 The following tissues were fsa? Stem, Liver, TestisErididais, toPrboestwatiet,hinStnosocrhm, GLiraiintaer:y Blader, Thyroid, Parathyroid, Trachea, Esatagas, Fituitary, Pasress. aFirtiea:al(Neakseh:41)8S3u6c2riticedSeixn eMxatlreemisGraupt (6) FCS 0 gon BacroBsceopic Qsermations: Lang Lsiineern KTiedsnteiys/Epdicnis Nicrhaescroepacl Otserations: ""BHilltaitperlael iotuietileessions, 0.2 a dia. in leit oie, Slightly arsed a"Bsosth, K4id.n5ey1s4p1ale2 cahn,d LeneltargLeast.eral Jobe, oth testes very small. "Sinusoidal ectasia, corte, ald SPpreocjieecst:hfuabter: o28ICROOIZ Suanarized ST ges 166 330 00718 ISnudmimvairdiuzaeld RSAiCnrgolsecoTpaibclaatndedMidcnriaoaslcopRiecpoOrtbse(rcvoanttiinounesd) Riker Lboratortes, Tac. 31 F3: Tuo Year ral Toxicty-Gncogenicity Stay in Rats Tale: 2 GFraitmea:] GMeaenkdesr:90R)3S6ac2rificedSeicn MeaxlterenisGrow: (8) FC-LAT 30 poe MicrosEceopic Dservations (continued): "-Cataract, Eilateral heart awciatridfietcails,,wcihlreonic soasuppurative, vitres "CPhrreotniitcis,praocgurtees,sivweileneshropithy, marked Liver "FDoiestta,l csoretniocnalc,lasrodecerlalteinfiltrate, wild Portal ole dict proliferation, ail Haeislatacyte alteration, vacuolated, focal, HeLpiragteo,celplouolralry cdaifrfceirreonntiated neoplase. Trabecalar nd aden patterns. ws "Avlavsecoullaarr miancerroaplhiazgaetsi,onm,ltiaflodcal, wild Hesorrhage, local areas, ald bPairtuaittsayrryaid ""NEoytstyexapnaircsedd,isntoatlisin plane of section Testis/Egiiais "Tsuibtuele atrophy, aspersatogenesis, bilateral, UThryirnsairdy Hadear ""tEaptitheexlainailnedA,ypenortplaisniap,lanseimopfle,secdtiiffounse, wild # Gystitis, chronic, diffuse, nininal The fatlouing tissues were found Lo be within areal Linits: Splers, Frostate, Stomach, Trachea, Esophagus, Salivary lane, Pancreas. dFnaitaea:l Wbeeerl:10(6R3T6e0rral SSeaxc:riMfailcee Group: 6) FOI 30 pre WacrVaisdconpeiyc Bservations: MicrKoistcooepyic Observations: Liver Lung "Tyst, 4 cn dia. "Cheon progressive neghropathy, asderate "PPoorrttaall abiolneenduuccltearprocleil]feriantdiiolnt,ratiel,eail "hascular wineralization, wile The fatloning tissues were fond to be within moraal Limits: PSaprlaetehny,roHiodu,rt,TraTcehsetai,s/EEsgoipchiadgpuasi,s,SaPlriovsatratye,GlaSntdo,sicPhi,tuiUtraircya,ryPaBnlcardedaesr., renal, Thyroid, SPpreocjieecst:nabter: 0281680012 Summarized STAR Page: 187 331 00719 ISnucnicvairdiezaelg RSaiznrgolsecoTpaiuclaatneedMifcerinoaslcopRiepcarOtb.se(rcvoanttiionnused Riker Laboratories, Tac. 3 FE-143: Too Year Oral Toxicity-Dacogenicity Study in Rats Table: 2 fFartaeu:d HNeaeakbe=rt1016)03T6e6r0aisal SSaeccriMfailcee row (8) FC-14T 30 pon Racrsseopic Observations: WieroHsecaorptic Diservatiors: LiLuvnegr A:g visible lesions. "Mwyiatciafrotciatlis,, arlednic nensative, "sHcupoelrsalrasiwai,neKraalfizeartiocse,ll,eidleibs, aaterate Hencrrhage, local areas, ail STphleeefno,llKoindianegy,tTiesssuteisswpriedifdouuands,toPrSoestwaitteh,inStnoouramcahl, lUirniitnsa:ry Bladder, Adrenal, Thyraic, Farathyreic, Trictes, Esopus, Salivary Gland, Piteitary, Pacreas, FGartiea:alGNeossiteer:401)6SSacTrificedSein eKxatlreentsrow (6) FE-IAT 30 poe McroLsicvzezric Observations: "slightly pale RSapalneaerny Slant "SHlaisgshtwliythmualcgeerasted heaoragic surface, 4.5 Hn 4S aa, in right anilla, NicreLsievoepriz Diservations: Necrosis, conteilobalar, 16 Purathyroid "HHaetateoxpasaiienseids,,noetxt1r6anpelaalnlearoyf,seacitlion Suir Fiibgrholsiyrccoenllsular neoplase with Iymptic Steen "Heinnsvtaospisoinv.sisS,urefratceeanseldceelrlaatreyt,. creased, wirket KTihdenefyo,llHoewairntg,tLisusgu,esTewsetries/fEopuincdictyoaibse, wPirtohsitnatneo,rmaS!tonLaicnhi,ts:Urinary Blaster, Adrenal, Thyroie, Traches, Esophagus, Salivary Blanc, Pituitary, Pancreas. nivel Noster: 18-3656 Sex: Male Sroups | 6) FEA143 30 pan Fate: ers 108) Teraimal Sacrifice Macro[scaopic Observations: skin Pituitary "Opacity, right ove, "Hair less on Links with scat formations "Rpaoisssei?bldearkdermmsast,iti0s..8 cn da. PSrpoejceicets:NoRsatter: 020130012 Sunrizec STH Page: 168 332 C0720 ISnudainvairdiuzaeld RSaicnrgolsecoTpaibclaatneddNiMcariomsalcepRiecporOtb.se(rcvoanttiionnused) Riker Laboratories, Tac. 30 FEAT: Tuo Year Oral Tosicity-Dacogenicity Study in fats Table: 2 Seial Kater: 103688 Sent Wale Braust 6) FE-145 30 pga Fate: Orie 108) Terminal Sacrifice Macroscopic Batrvations Gontined): B MaresViizgzeirz Q(eeroarttiinocents): BEireeral Heart ViLtivneery Lg PiFtaracirteaasry sSaebivary Slane Testis Spicsemis "Fates possibly somewhat enlarged. ""Shientuisnoaildaaltreocpthays,iau,nilcaortteersa,l soderite "CMaytoacraarctti,alunfiilbartoesriasl, focal, wile ""Dbiorratnailc apsrroegnruecslseiavre cnesllhroignfaitlhtyr,atea,cteer1i1te Naolrgonuclear cell infiltration, wattifecsl, "Hveassecruelhaargew,imeLorcaallizaatrieaosn,, aailtdd ""FAoelryaorntaritis, icin ""USlicaelra,denairtkiesd, chronic, oderate Falyarteritis, aild The detlonizg tissses were fone to be within sora Limits: Spleen Srostate, Stosicn, Urinary ladder, Thwoid, Parathyroid, Traches, Escghages. feiael Noster: 10-3067 Sex: Male rot (6) FC-IAT 30 pon Fats: Waele 108) Terminal Sriice Macroscopic Dbservations: Wieroscopic Diserations: Heart itrey Liver LPuanngcreas Piteitary STahlyirvsairdy Slang Witiey Bladder Xo visible lesions. "Myscartitis, chronic novsaparative, ~Ewairtainfiecaaplr,ograessive neshromathy, wild "pPorretlailtisa,oneancauctlee,arnlcell infiltrate, wile "Fsocratallarbisleimrduacltinpartoileinf,erawtiiloen, sile h"biienroamsatrashy, aild ""SHiyaplearcpelnaistiias,, Cchcreolnli,c,fomzaarl,kedeile "Not exanined, issing STphleeefno,lTleowsitnigstEipsisdairdsyawiesr,e Pfroousntdatteo, bSetowsiatchhi,n anroremnaall,LiPnairtast:hyroie, Traches, Escphages. SPpreocjieecst:Nfaabter: 0281080012 Somariond STH ue: 49 333 00721 ISnutaisvairdiuzaeld RSiicnegolsecoTpaibclaatnedMiicrloscopRiepcorOtb.se(rcvoanttiionnused) FLAIA3: Too YeaRrikeOrralLabToorsaitcoirtiye-sD,aceIgnec.nici3ty Study in Racs Table: 2 fFaitnea:l (Mhaansdteer:106I)RTTer8sinal SSuecriafilcee row (6) FCAT 30 350 Pacrascopic Ghservations: Microhsicraepniacl Dservations: seact LiKivdenrey Ln; Pituitary 43 visible lesions. ""WSyiencuasrotiidtails,ecttahsioa,ncorretnexs,rawitlidve, "Dwhirtainifcaaplr,igrweislsdive neroathy, winieal ~Nfeacrrtoaslisa,ongfonceacll,earwilcdell indidteate, a12 "Hveaasccrurlhaargew,inselratliidzoactailo,s, sistiel ~hencas : TShpeleefno,iloTweisntgisltEipsiscuiegsyawiesr,e Pfroosttatteo,beStwoimtachhi,n sUarrianaalryliBnliatcst:er, Thyreid, Parathyroid, Traches, Escphagus, Salivary Sland, Pancreas. Ffaitnea:lhKeanetrer:701)6-S3a6c8r9ificesSexi:n emxalreesisGroups 61 FL-143 30 gan PacroSscnopic Bsarvations: Large Intestine WicrLosicvoepric Gservations: Arenal Esophagus Lung Parathyroid SSailnivary Bland ThTyrraochieda "Lerfetctsaild-eseorfotaslcroatbusncesusl.cerated with "tadrikleadtatiinopanctoifonreamtaitneirnvgincaolloncolaocn alnesss containing fecal material. "hale "HOintehionf pneariualprLeisneintts ""ANlavteoelxaarsinaeadc,ropwhiasgseisn,g mltifocal, aild "NHoetscerxeahaaignee,d,wlwtiisfsoicnagt, #16 "-Niobtsceesxsan,inseudb,cuwtiasnseionugs N"hoatt exxaatniinneedd,, wmiissssiinnsg The following Spleen, Liver, tiKsistuoeeys,eHreeartf,ounTdesttoisb/eEpwiidtihiynnisn,ormParlostLaitmiet,s:Stomach, Urinary Bladder, Pituitary, Sul Intestine, Large Intestine, Pancreas. PSrpoejceiecst:NoRsatter: 0281080012 Suarized STAR Page: 179 334 C0072: ISnavmirhaal NSirieatsrecaLTpbaecrlaataadtriMeiisc,raolsIcnoep.BiecprBtra(ctcinotinnsns) F-13: To Yer Oral Tec Occ Sad is Rats Tele: 2 aFitle hNeohes1801)3T7r0ina SSorcfiaclee Brug (0) F163 30 go MacrSosiceotptiecerOiservations: HesLsiee Gratis: ler fwansirs TeFSsatliisirydBliadneyis ""CiTlehs,ug1,7xpalLeY cap0tea.ra of pres. vFaarsae speerssreslseiavrecnellewsitit,rtwerew:ie uPosrtealdilseiesriltinptailofne,rat1i4on, 14 HeWzilcrdciifnieonetite, dctila paten. Lise cwinaetaorf af,itHsildsirns SPenln y rte SFaillpurdteriittiiss,,aevornact,ewieate TShleef,aiecritr,irsostnaw,eeStfonne,toUrbienarwyithPiantesre,alMrLeinlt,:Trai, Parathrsi, Trach, Epa, Lu he (sari). Fwitde hweraet1081)3T7r1ea SScurtifRicee Grog 6 F06530 an [-- HerHoaeresn Dmratios: iEttr is LiLnyer Paarcsrtiersest TThSerisettiiie,arbBiludeiis Tron Ao isi sien. SHeitnneiandesctssi,sicrt ile "Feerrali vreoorcelsievre cwllawhpit,nter,iewdld uFscrlairsweralwinnctiloenn, 1i1i6ltrate, wld aSetiunssitnr,is4i1n6g FHoetrerxisiss, awisriintg e Koott nniannes,, iissiinngg hSpeiefso,lleowritng, tParossetsatee,reStfoenned, tloibsearwyitWhianteerrm,aliianrts.: SPreocjoecnt:oathter: BEET Sunrize ST piges 71 335 00723 ISnudaimvairdiuzaeld MSiicnrgolsecoTpaibculaantedMifcarinoaslcopRiecpoOrbtse(rcvoanttiioonused} FE-L43: Too YeaRrilOerralLiTbeoxriacteirtiya-sD,acoIgnecn,ici3t%y Stay in Rats Taste: 2 fFaitnea:l tNhaesetesr:1061)0-3T6e7r2ninal SSeaxc:riMfailcee Grout (8) FCT 30 gon NacrFaistcoasiitcarsyervations: Testis/Egicioneie MicroVsicdonpiecy Bservatioes: Liver Lrg PPairtautthayrryoid Testis/Epididnais Thyrie wLeaftt atersntis sual. ""DFiorrotnalicapornoegnrsecslesairvecselhlroignaftilhtyr,ates,ini0s:a1l6 Hepatocyte alteration, bassphilic, focal, "aiiaisdcalar wineratization, 10 ""Nhadteneoxnasnined, not ia plans of section "Tiarbkuelde atrophy, asperaatogeesis, unilateral, "Ost, colloid TShpelesfsa,lloHmeiasrtg,tiPsrsousetsatew,ereStofonuancdh,LoUrbienarwyithBilnasdmeorr,alAdriesniatls,: Traches, Esophagus, Salivary lun, Pascreis. minal Nobert R375 Sex ale ours ( 8) FECT 20 pon Fate: (heeks 106) Terainal Sacrifice Macroscopic Observations: Nicroscopic hservations: Li[v2er Ling SPaalnicvraerays Gland Xe visible Lesions. ""DRieerotnalicoanreorgarcelsesairveceelslsroinsfaitlhtyr,atew,ildald Hepatocyte alteration, vassslated, altifocal, Hweigealocytosis, ainiml "Piearsicvualsacralaairnwsranloinzuactlieoanr, ianlddiltrate, ald ""SHiyapleardpelnaistiias,, acchirnoanricc,elol,desroadtlear, mile The following tissues were found Splees, Heart, Testis/Epididais, to be within sorma Prostate, Stosach, ULriiintasr:y Bladder, Arenal, Thyroie, Parathyroid, Trachea, Esophagus, Pituitary. PSrpoejceiecst:asfatter: 0280012 Suanarized ST se: 112 336 00724 BESTCOPY AVAILABLE Sfwainve nsieeaTLnaothre eiiabteetnactoinotnin E05 Te Tr Gl Tore cpt Sy i is nie 2 rFet osaBTeis n Sreee G {0 Ft Jr---- [-- 5 vie so. A y wiiiryeosr sonar hio n DCriet rweeptinienaaeonwsttiyi,Eeidie sre sh, win, wie, frosee Semnieee,hwaioef ein The toning tes ar ed 5b th sl it Fin Sos Ss Spleen, Testis/Epididyeis, Pn rei, Prostate, Stomach, Urinary Blaster, Adrenal, Thyroid, Trachea, el ns es pr Nairda Gratin Birungd wr of chiMn,i1d2dcna, Hatin Shltydutwpeeesalnsesnennanpees 03o0h Ner--snc Bartios: fi itis, dvs espn, ail fJ[r Di raare auwrrioeennwiioecs i6 Hjo--t ererneann ahlevo,m isdk, ite r i -- a Siero-- , sens SSheihteensirFnagvhes,wsnnsre Ufnr SbeaicheKser Piorte, Pho, Tah pgs, Hfare vrs amc ! [Or66723557 BEST COP! AVAIAHBLBE LE SBas sa Tooew aDshanttmacrioonns FEAL: Teto Sl ToSiicty Sey i Rts at a toneohBrsain Snwe Bo 0 06 Reseeerrnieonn SSettser ihhotn t in ot reoetoeSSuman ipeivie mien, pe - fsetrirlyetwaittpee,tsJtia, wnwai,kgi0a it iitooit nSaeewsriSehaina tok onoadl oFtbens ETairatiorwwisitsi ,, wwiaets SSTiwetams wTdaiiittvseo,sowrwame,retes, wii, f[orr oc ehe tiosnisaes,mrVointestts o0ristiorrsdPLeirtit, Tt, Ss vl ia BS e ee 0 F -- ipiveyn orStaontctivwt,onsssaptw,hwitws e eEpAndeSeeiinfoaiwit wie, - eytrsrisww,aigsiio,ndnwitle ahr ttoeenin,t,ri1esiearms,toanta, Sfeoirn age soni srg 0 338 00726 ISnudninvairdiuzaeld RSaicnrgolsecoTpaibcalaantdedMiAcrriomsacopRiecgarOtb.se(rcvcanttiionnased) . FE-L43: Tuo YeaRrikeDralGbToorsaitcoirtiye-sD,acTongee.nci7ty Stuty in Rats Table: 2 fFiatnea:l (Nkneebeesrt106R)3T7er7minal SSaecriMfailcee Grow (8) FCT 20 gpa MicrTeeszsetsiisc/EGpsiceirtaytaiiosns (contisue): "F3elyirteritis, aild Leydig cell adenoma, anilaterat STphleesfso,llHoewairntg, tPirsossuteastea,reStofnoauchn, to be within normal linits: Urinary Blather, Adrenal, Trcic, Trachea, Salivary Glare, Pituitary, Pascreas. fFnaitae:al fbueesir=t 4I9) ISaRcrificedSeixn MeaxlterentsGrows (6) FC-IAT 30 pon Persscosic Biservations: Pituitary MicrLoiscvoepric Dservations: trey Liver Lung PiSptlueietnary Stonch "Hesorrhagic mass, 13 0.7 ca dia. Fossibly slightly pale. "Chane progressive neshronathy, il "Portal soonclear cell infiltrate, wild PHoerptaatlacybitlee vdauccwtlaptrioolni,ferdaitfifouns,e, wisloeserate "Hveassocrurlhaargea,inweiratliifzoactailo,n,wialidld H"ehsesrsoindserasis, sile "Ulcer, aarked The fotlonis tissaes were found to be within normal Liits: EHseoaprhta,guTse,stSiasl/iEvpairdyidyBlaainsd,,PrPoasntcaretaes,.Urinary Bladoer, Mresal, Thyesi, Parathyroid, Traches, Ffartien:al easbiesr:1081)53T6e0ra5inal SScexr:ifWiaclee Grow: ( 6) FC-IAD 36 pon Macroscopic Diservations: Wieroscopic Oservations: HeKiadrntey ug Pancreas "Ho visible lusiozs. ""MCyhsrcoanritciaplragfirbersessiivse,nmelphtriofpoaztahly,, waiil2e "bHaesscoarlrahragev,ineLroaclailzaatrieoans,, asiodleate "hyperplasia, acinar cell, nodular, aoderate The following tissues ere found to be within sarmal Linits: Spleen, Liver, Testis/Epididynis, Prostate, Stousch, Urinary Bladder, Adreml, Thyric, SPpreocjieecst:uRaabter: 0281020012 Swiss 8 pigs 0 339) 00727 ISneiavirteadl SSaicrrsalsecoTpaisclaantdePAenaislep:gSesecraoatiionAsc : BEST COPY AVAII ABLE FH: Too YeaSrilreradLTowriiceeE,rsaiet,icity Sad in Rats Tale: 2 Fiiewr fbionsee1T3ena GSetiNnae beg C6) FE 2p Tr fneiinebrBesatweiesfeuoti6sw:ih sees ints Gertie Fuattait, Tas, Esha, Satiey Sich, Fitter. Fdrietd tKonte 11GTErae SSeesttiaclee bg (8) RA Tan rirtsesc Beans Hae tote ""pEahcitay,aylettae,e,Ta To, atte ts get Rerearic Reta: He prre PSrlr, itpre) ""Cteagtiac,rewgrietsseinvel eropath, siete FFoulrtts,alatetez,aacal inflate, wld aSisachzaarritsimse,radlrizotsi,on,wewidg Fibrana SineF,iftorot, eTeesswrte aac,d 1ProBsetawtie,thStraecnhd, ULriimniatrsy: Bader, rsa, Thai, Frito, Tacha, Shae, Pitty, Pare, FGeueet tNhetss10) Torna SSeeeriflicee Sgt (1 R16 pn HerSshsionic Seratics: WereFsictssatiacryRserations: Liievre es Firtostiattrey san SuainsdedLeufltcehriantedfaStoptalsa.matry esis, igit "Sul raised esorrhaic Lesion, .2 58 ine o"Brrotnaic mpornecgelsesairve cneelghenoigittrhay,tei,leitd VPasraliar,svienrtaeirisatittiioanl,, iclodnc, stil, Raelrdiiscalar soonclen inflate, wild r"atsraotnistis, wit, ai ohtudtlen,atwiatkie,d siceratine bilateral, PSpreocisees: Naatbe: azcK012 sanriaes sa gee 340 00728 Saarized Single Tadulated Aninal Report (continaed! BEST COPY AVAIl ABLE Individual RaRcirkeerscoLpaitcoraatnderiNeisc,rasfcaocp,ic3O0bservations . F143: Too Year al Tonicaty-Dacsgencity Study in Rats Table: 2 fFaitnea:l fMeenasdhesr:106I)R-TTe8r1einal SSaecxriMfailcee rowpt (6) FC-IHT 30 pon FicrasTcheysriecieBhservations (continued): "=Fellicular hyperplasia, cystic, wnitateral, warkec The dallouing tissues were found Le be within normal Lint: SGpalceaemna,gesK,eirSta,lTaersytisSlEaanied,isPyaanicsr,easS.tow, Urinary Blaster, Adrenal, Parathyresd, Trachea, Fdantiea:al(KMaeteesr:1081!8-T3e6r6a2inal SSeanctrifviaclee Broupt 6) FC-103 30 pa Nacrascosic servations: KiersLsicvaepric Obseriations: aerenal trey Liver try Testis Bpididinis Trait "Hotties "CNoorttailcaarl bvyasceuropllaastiiao,n,colrotcaels,arfeoacsa,l,asloeterate "CChartoenuiicns,prepgerlevsiscive nepropathy, a11 "pPeorrttaall abizlseonsdculcetarprcoellilferiantfiiolnt,ratwei,ldile "Chrasstcooitdardewgienneerraaltiizoant,iorm,it4i:f1o6cal, 1g "ALlevretoilgarcelmlacrhopprhpagleass,ial,ocamlilatirfeosc,al,aatweirlidte "hFyoplelripclaalsaira,dercceelsl, focal, wile The fallosing tissaes were found te be within roreal Liits: SSpalleievsa,ryHeGilsatr,e,StPoimtauciht,aryU,rinPaarrycreBalsa.dder, Parathyrie, Prostate, Traches, Esophigss, Ffaitnea:lGNeaebkesr?108I)-T3er5aimal SSaecctrifMiaclee Grout (6) FO-103 30 pra Macroscopic Diservations: Microiscdonpeiyc Oservations: Liver Lary Xo visible lesions. "Dironic srogressive nesdrogatiy, id "THoecpaa!tzaeryetaes,alwtedreartaitoen, vacslated, "AVlavsecoullaarr awsirnoerpahlaigzeast,ionm,ultwiiflodcal, sil SPpreocgieecst:Maoatter: 0281020012 Sumrized STH page: 11 341 00729 BEST COPY AVAILABLE Sanvwiies oilse TsaliadtcmioncReporGt r(cointisnued) H-14 To YeHreGealLTaobnris-oBriceasg,nIintc.ity Stat in Rats Toe: 2 fFaitnea tweehrt10S0) EaEriel SSectiaflie ug (1 F105 50 pn fFeatima -- Jot vind, rat ie plate f section STheewnfo,llrowrin,g sTsesetsa eorreefsun,treobsettwiet,hiSntrouat, rLiittey: Made, Area, Thre, Traces, Tatras, Sati Ehud, Fitba, Press, Fie ane 100) Tras Sritics TE [I -- Pr Sel -- joort Ler ws Stary Shue a isd Leis. Stinrsciittael ,sctdasoa,c,corfties,heari,dwied "Yreancinsoeaarraeteiosn e1p6a, Hid arrttadl siolsencultearprcoleilferiantiilorn,atae,lewile "daivlear swuinceratluigzeast,ionm,ist16o, ald Silatenitie, rene, sate TSheeenf,etiToenssstiisseesrawsr,e oPruosdtatteo,beStwointchhi,n sUorraiTBiltast:t, Thyra, Farsthyrei, Traces, Eps, Fit, Pres. Fiiakeneeeres190I) ESeSricaSeitn nalee nrat (6) F103 30 pon HurSoicsnic Gssrations: WcreFstaspitcurByuration: [th ipnye Fitessiattiery SSiinvry Sand "Aulnltaucltcerrante.d Lesion on aft bid fostiat. GHaeruocnoperoagbreasasitvieoanpr1aa6thy, eines pZeartc] saortmiaeticoon:,ismiitetate, aie Spreevseanitis, te, aie oedtctaariadii,ti,issilnagraine, wriet -- Mages--her: zc? Surizes STi Page: 8 342 00730 BESTCOPYAVAL ATESAuRap:mapreiztevd vrSiinvgclaeelTsLaTbuoltwsstdeodrsSAnisimo!cscRaepo3rm0t t(vceorntsininuetd)e ate 2 eFiv lnaer,14T, SEitifoas aoleeises {0 F050 J Tin -- Nja} uoe trpy, sprntsgsts, wilt, ePThreosftitSniang,taosewsswraeteSru,d AorebentsiTtheroerrionitde, Tite, Exe ies, Feire eVrhs BTEern wSeiraee Bogs 0 FA [---- [r-- -- leon PSaacoitdv-- cpmaramtioni, f-- omale,natel, aie SHiitm stunt ASJFaeitpna,ltzcptyrtse,ailttewreatmniosn, vacuolated, focal, STioetrf,itii,trrHLoiks,esTwEeeiehsftos,arsa,beni,rtohsaa, Siolki,taWin Sut, een, Thre FFiatsn hNela8 SuriticdSsin lmeooiGran (0 FT rsscTnorirtcn Btiumteri: "TSotsisitwhhleorst tips fli ioLnry TSTieuetshmiwatdevp,sof scecnehittio,n Tesairbiions ieetates errss saentd.ses, Werrae Buration "Stiialllaeilitiso,n,crIosnl, wsehsa,rerid rt Awirridekiatiilas,elasertea,s moiwse,a0 _Hee--r vers cnc: Sunnrizes STH ge: 9 543 00731 Sneavniiiaal aSirnaglseeTpicbla1tneddWreraelserbscghtsetatiinont : RAS To Youir walLrTaroites,chee,pt Say in ats nies 2 eFta eWraers 31: 0r0iceSens lteensrot 1 61 FAG 070 Wersbasrc sertion (tines sr ws JFurassreets TFeirnsions f vic sp weetie--ie---- aTtotaal abie anprGoteeraitrioant,ea,iile Ceasies tdrpanelsatiionn,flS,ieiheS16 aHtinswrpaain,tionmiiai, we PRrealeutiiatss,Seextirs,imieeei Isa ri, Staebaet, wed SJaat veaanrensesitiisn ste of sitios JPatoervatiueysbaussnes ---- FTortsercael,mawsesea acl, aerate Ect, erste STehefeelStivsicth sWieveasredifrods tToobre rwiethTinotsoern!Eisnptass, Salivrs Slant, Ee Fitaian. SFuiet iaeites)aSEerticdSein. wmirinisen 0) F103 0 [ Frit-- Coanit Te[stis iiepis Wrpsst) Garmin fitvy Pragrthia FSiitets Snneaoreldto erreidndstacbolyinanaihse.. aStheowayn ishegpty wwe. Zope sal ivemraecpsecsei, csorute,eayia wits Seespsterst1w6aataarian,s aerotewen 14 auaeeoainseat tia0tsehe41o8f ection SSeevveers, wie SFpeociees: aRart s CRA Sonries si re 10 344 00732 BEST COPY AVAILBBLE rv ch Microscopic Observations (continued): i. Testis/Ep:didyais "Left testis somewhat small. sowrizes st ge: 1 345 00733 Suanarized Single Tablated Mind fagert. (continued) Inchvidaal MaRcikreorscoLpaibcorantdoriMeisc,rosIcnocp.ic3D0oservations FL-143: Toe Year Oral Toicity-Dacogeicity Study in Rats Table: 2 nina] Mondor: IR3690 Se: Male Grows ( 8) FC-14T 30 ppn Fate: (Hest 106) Terainal Sacrifice MicroPsictoupiictarOyhservations lcontinued): Testis Epiciyis ""Tjusbtu,lepaatrrsogihnyt,ersspeteiramatogenesis, unilateral, irked Toe fatleuizs Eissaes ware found to be within normal Links: Spleen, Lars, Prostate, Stomach, Urinary Bladder, Thyroid, Traches, Essphases, Salivary Slare, Purceeis. Faantiea:al eNruarbsert1081)6TTeSr1ainal SSaeccriffiaclee Grout 61 FOU 30 an Sacrascipic Baeevations: Masaary Shard Mi[ergsiczaic Dserations: Kishor LLiigver Purcreas Pasriaethyroid "Suscetaneous, mltilobular mass, S51 415 a, leit. "Myecardial fibrosis, local areas, wile wWirlsctairfdoiatli,s,wiclhdronic nonscppurative, "Civoniz progressive neprogathy, wile "PPerlevtiacl wwinnoenruaclliezaatriocne,lliilnfiltrate, a114 ~"aacsicnaalraratarienaehyr,alisziatniio!r, A614 ""NFeitbroesxaamricnoeada,, nsootbeiuntapnltaonues of section TTheestfioslflEowsiincgidtiiss,seePsroswtraete,fouSntentcah,beUwriitnhairny rBelvaesaelr,Linbidtrse:nal, Thyroid, Traches, Esopages, Salivary Eland, Pituitary, Speer. Fnaitnea!l HNeoecih=ers10R6 3Te2rminal SSaecx:rifMiaclee Gras (6) FEIT30pom Nacroscopic Bservations: NicroKsicdonpeiyc servations: LLuinvger Pituitary Ko visible lesions. "Dhranic progressive nephrcgathy, eile "Fvearstcaullarapanianreurcalleiszratciaolnl, iinflidltrate, w1 "bierona The following tissuts were foun to be within normal Spleen, Heart,TestisEpididyeis, Prostate, Stomach, linits: Urinary Bladder, Adrenal, Thyraid, PSrpoejceicets:aRnabter: 0281080012 Sumarized STi Page: 12 346 00734 BEST COPY AVAIL BLE cane soe rites bieaserocront RO: Tn Ye eno Se 2 raw Se BR BT enrieeaBnurae inntSiiatuns Shosrursean.s mts TT A ra ---- -- ne gpaetet net ts vt sm a_i pn rt aon wimn-- Minsr ry i pE it naT M---- ne A air0 - 2 lir asia,i Ny, pou eeremewnsnaa bwiie , a4 i=e es E iTkinwgnI SBBOraeenmHinns ose S--oe -- ot--Rar, Ted, sts, Tris a nn Tw wS pbroeonwsar-- io Fate: (eek 106) Terwinal Sacrifice - ath 05 S mip wat Bsorsatte cn Sunes sae 3 347 00735 ISnudmimvairdiuzaeld MSaicnrgolsecoTpbisclaatneddMiMcaraoslcopRiepcorOtb.se(rcvoanttiionnused) FE-I43: Too TeaRrikOerralLaTboosriactoirtiye-sD,acolgoecn.ici3t0y Study in Rats Tale: 2 final Fate: (NHaesbiesr:106R)3T9er8ninal SSaecriMfailcee row ( 6) FC-IAT 30 3pn FicresLcivaepric Dhservations (continued): LiFunsgcreas Pituitary "PPoerttaall bwirloenauclcotaeprcoellilderiantfiiolstr,atwei,ldwild ""Hbylpveercpllaarsimaa,croipshlaegtesc,ellm,ilndedular, wild "hderons . The following tissues Spleen, Heart,Testis were Fouad tc be within acraal Epdidyes, Prostate, Stonich, Limits: Urinary Batder, Thyroid, Paratha, Teaches, Zssphagis, Salivary Bland, AFoaitaea:l GNeeeekrs:10(8E3T8e9r5minal SSeacztriWiactee Braust (61 FO-145 30 pon Macroscopic servations: Wicroscapic servations: renal HeEasorpthagas Lievyer Pituitary ko visible Lesions. "Rneetulolfarpyaicelp)resheyspterplasia, focal, ale Not exanined, wissing "Wwyistciafrodciatlis,,adihlrdanic nonsugpurative, ""Pioarstcaallarseinornacliiezaarticeolnl,inaflidltrate, wild Fresaonia, interstitial, cheenc, focal, aild Not exaniaet, wissing TShpeleefno,lloVwiidnsgsy,tisTseusetsisw/eEraeidifcoyuanids,toPbreostwaitteh,inSntoorwmaaclh,LUiriitnsa:ry Bladder, Thyroid, Parathyroid, Teaches, Salivary lane, Pancreas. Ffaitnea:l ONkabeer:721)0-S0a1c0r8ificedSei:n eFxetsraelneisrout | 6) FL-145 30 pon Macroscopic servations: Nanaary Bland Microscopic Diservations: Khiidrneenyal Liver Lung "Lalregiet uilncgeerianatledaaresss, 1.5 1 LS ca cia, in ""SCihnruosnoiicdaplrogecrteasssiiav,e cnoersthevso,gatwhiysi,maalinieal ""Hveaassctuolpaorivasiinse,raelxitzraatsieodna,llmairnyi,mal4ild PSrpoejceicets:MaRsatter: 0281080012 somarive 51 pige: 1 548 00736 ISnudmimvairdiuzaeld MSaicnrgolsecoTpaibculaanteedWifceriuoaslcopRiepcorOtb.se(rcvoanttiionnused) FLAT: Teo YeaRrikOerralLaTboorxaitcoirtiye-sD,ncoTgoecn.ici3ty Study is Rats Table: 2 Ffrastaee:l (Mahsebiers 12()BS0ac0rificeSdeni:n Feexmtarleesisrow: (6) FC-1AT 30 gpm MicrosNcaospniicryDsElearnvdations (continued): FFarractrheysrseid FiStleeietary ""hbeiimnsarcaartcriorgohyn, winiaal ~"bNeoetroemxsanined, rot in plane of section "Hesatasoiesis, extrasetllary, increases, whet HTehaertf,olUleowrisnsg, tDisusruye,s Setroemacfh,eeUritnoarbye Bwliatdhdienr,seTrhmyarloiLdi,mitTsr:ache, Esopmags, Salivary Slane. Aoioal Naabert (B-4707 Sex: Female Graust (6) FO-145 30 pga Fate: eers 90) Found Dead MacroWsacseasaircy OSblsaenrevations: WicrPsisctaupiitcarsyervations: vhiidrneesyal Fvaaarwyary Gland harathyreid Pituitary "Lawrigteh cbylsotoidc, minssp,er8inxeal5xa3 2T.i5ghctn, filled Heienrgruihraaglicarleess.ion, 1S 1 1 ca ""SCihneuasnaiicdaplroegcrteasssiiav,e ncoerstheera,patihtyd, wile to "aHeitshian rroiruoalnLinits "GNroet oefxapnaiivred,prenseetntin plane of section "Asana STphaewfne,tlLoiuviezrg, tHiesasrcte,s Lvuenrge, fUotuenrdust,o Sbteonwsicthh,ieUrsicnrasrayl BLliancidtesr:, Thyroid, Trach, Esopags, Salivary Eland, Purcreas. Ffantsea:al GMeasdheer:105R)0T0er8ainal SSaecx:rifFiecmeale Group (6) FC-1AT30psn Mascoscopic Diservations: PiPtaunintaaryGland MicrMorsceonpiacl Gservations: ""RSauiaslledsweadsisl,ar0.m5ssc,a d|iac.a Gia, in left rariiglhlta;ingfaairzgaelaaasrse,s,$153 5 ca, in "Sinusoidal ectasia, cortes, soderate SPpreocgieecst: MRaasther: OZBR0012 Sanit ST8 Pages 16: 349 00737 [Saoamrrtishd Sige vw Tut ia Set Laertrie, Ic. 3% contin Ee: To Yur Ba Tosh copy Stay is Rats ie 2 : rFius tNaaer15BTrSincSeriecae Gow: (8 F050 on WirPaeaysyeSSadrton conti Jsa}tiwaonend, rt ie she of scien Gteiaty TSieonste, ate Boheulseftnlalo,nsSo tiviistesgElre,ertfc,urLney,teoDryi,tSiomrem, rHairsysBade, Thre, Trach, Fritt tvkaer,39D) S0critceSeicn neoleesSo: (8 F645 300 WarsiaBartion: econ Gera BEluubsaes,hs0t7icna irant tnd wh un Gor TeLiitsveoensosff aswainteiig1nh,st1p1le03 eh 1. fr Krieer!-- Seinncasiaatlua,rte1,8 wie ine eettl swosmeen rcololmtta, owiile owvnary Sit Stwielrticairate, wld tPPerctitueysst aJftrwwyainnes,, aiispane of section fos SWee is, wtraeslany, roses, Hheerft lUraag,tOisyts esuechf,ebitsasbe Bitehrsrhloii,isT:he, Esphs, Sliy hse, Howe Species: vRaet : ec? sunrine si ue ws 350 00738 ISnucainvairdiuzaeld aScinrgolsecoTpaibculaantdedMiMcariomslcopRiepcerOtb.se(rcvoanttiionnused) FE-1A3: To YeairtearlLaTboornaitcoirtiye-sD,ncIongce,nci0ty Study in Rats Table: 2 AFratiea:l OKieelre:10(9R4Te1r0minal SSeacxriFfeincaele Geaczt (6) FEA1A3 30 gan MacrFoistcoupiitcirDyservations: Naonary Elant Wizrescesiz Gssrvations: biresal PLoansgsa Shard Rtaarraythyrait Pituitary ters ""LHaeregrerhwalgtiizloataesls,ir0.a6assc,a d9ixa. 1.55 3 ct, in eft snguizal area. "SCionrutsiociaclaldeegcetnaesriaat,ionc,ortseosd,eraatreked F~ihbasrcsualtaerrownianeralization, sil Extensive necrosis of tuscr, ""hsattexsnined, not in plane of section "atom "Leyiosmyonslsants, warked SIphleeefno,tlLoinvienrg, tKiisdsaeteys, wfraertf,oSetomtaochb,e wUriitnhairnynBolrasdaderl,imiTtrsa:ches, Esophages, Salivary Slane, Fascress, Thraic, - SFnaitnea:l Hsetcokret105I)-T1e1rmiml SSeaxc:riFfeimcaele Group ( 6) FE-14T 30 pon NacrasWcaoepaiacryheElaarnvdations: Microhsecroepsiacl Dservations: Kidney Liver LPuangsay Eland Pitsitary Splens "Lairnggueinmaalssp,er1in0e3a1l0area4.ca, is right ""CDorrtoinceal pvraocguroelsastiivoen,shlroocamlatahrye,as,a:l#:1 Pelvic sineralization, #1 ""WHaespcaatloacrytaeinvearcawtliaztaitoinon,, mwaitniifnoaclal, aild "Fitraatercms ""Hhesiantoapsiesis, mteanedellary, increases, nderate The following tissees Heart, eras, Ouary, were found to be Storch, Urivary Bwliatdhdienr,soTrhmyarloildi,aiPtsa:rathyroid, Traches, Esophages, Salivary Gland, Pacreas. PSrpoejceicets:NaRsabter: 0281020012 susie ST ise; 10 351 00739 Snaainle aSiegkeaiTbclaatnedHteearltfaoat asttiint F162 To YuRikaerlLTsoornaaeriyes,caTep,i Say i Fits rates 2 oFaree eYsres3100S1i2ficetSain [RrRity-- jt Wrehsatr:esBertin: prses ons ww ws fe--r-- [sreye H[=it FreelssEro {1 FUE 0 30 H- arti ws, 1.35 8 he tTee pwinis trenuendS1wi5th163c in oFandsllahre,otic ssh 211 on in rit Sen esl 0.3 ca di. Seiiririnced,,tasfeire,ecowre--s--, --t--r.e, DHriveeasrmonpltisstioen,agrHeophttly, aininl eerraall abmeedtaetrpreaeilsenaftitornatwei,eald AHrvaalr salaipest,ons,iltfe, wid Seucrailen Toett cel atoms TSieeenss, erate TShheoeettSntiwgcthistseosmeyredfiorun,toTobreowridthiPnaarrsme,LiiTtreahen, Escuas, Silivy Sa. Faiitea tNeakske1TEFSt beatSe Fie Erg 8) FI 9 on [ fe -- Vas Wersrsiaaic Bertin: LTwyianesSect SLeitghtteaeehrs bis sll cei twist iYrs e0.a5s8y dairntntriendaFtirlieed with dr sey tas. J erase, tifa, ie Suspaere,wmrlasatti,on,sosirttee J nie, Hebe frp Species: Rat Sania S18 ge 18 352 00740 i Sri AiWlie nTaitgNfialegr2Bt cona Tots: 1 Yr olTe ct St i ts ie2 avane Fe Sg 0 on NeFeaHsnoienetins its Hsens, wtrasiivy, sen, te Bsiitoengt, att aSheenenl,eontrSe yseHewSrse tfnab,0ssRtersdoitre, arti, Tn S i vna BeasSeaTre og 0 Fn Nepsreedtio: Aaptsi imig vDr ne 85275 PioattottelGoa : to os rts wn I ---- KaSeron,fcuer0 slit rd Ih te rt fo. i Srre,waaaiet swaatsstewld Gierry sit SHinnrunso, it iis Es Seth olin, es wos in PBIeinFalSninnrieseawoSoat 1Roesitae rtd,Lht:n stun, aly ht ois vaet: anno Sunrize 50 igh74353 Sonic a Sriee tawlatmeaairaeprBwtiioe FEA: Te oS Tee Sects Say i ts ote 2 we Weio n enee ro 0 Fn [AP v}ite Ln. [ To -- Svoert wi, cto, ital, -t vi a Aa e wn-- t, wee vein sie b-nmy iami,ti,n waitt f, nos TfSromame BHieeeteer osplie of ston ow bess, wid O eu Bp i Toro, sce, Estas, Sn Sl BTnvs oesk Serreoi eg (0 70 [J o4h -- ti Wii on be pr uy rp ie ep -- nn bElri Tn imtms 1h etn ae Te ra. crehearmfaodon soo,ibvaPhyeanByt,sSarhPl,ociSevtmes,Sierin Mate, Theis cFeoenvaatne: cnn Sontag 5 grCoo ISnuainvairtiuzaeld MSaicnrgolsecoTpaibcalaatndecMidcraoslcopRiecgoO.bse(rcvoanttiionnused) FE-1A3: Tao YeaRrikOerralLiTboornactiotryi-eDsn,csIgnecn.ici3t0y Study in Rats Table: 2 Ffaastnea:l ONeaesdtesrs108[!07Te1r7ninal SSeanctriFfeimcaele Group: (6) FC-143 30 pe Macroscopic Bservations: mFiatsiuiatreyryBland MicroMsicroepniac! Bservations: [2 Kitany LLirvger Hannary Bland Pituitary tteras :Heorrhagic mss, 1c dia. "Leorbsatliacr laoswsl,ar43as3s,x 2.5 cn, in left asidlas 25521 12a in prion aren, "Left atrenal nlarget. "SiEnnulsacrigdeaalestectoafsi1ae,ftCoargtreesn,lmadrokeedto massive "Cshirnounsiocidparlogrecetsassiivae.sepropathy, sinisal "PHeelpvaitcocsyitneervaalciuzoaltaitoino,n,ameurlatitfeocal, wile aHsiavelcatarr amiancreoaplhiazgaetsi,ona,lteiidlodcal, ald "HFeisborrarahdageen,onLocal areas, sodeate Bhaileancstcaacreclienons "Hieron "Dystic glands, wild The folLoning Ssleen, Heart, tOivsasraye,s wSetroenafho,unUdritnoarbye Bwliatdhdienr,noTrhmyarloiLdi,nFta:rathyraie, Traches, Esopragas, Salivary Blane, Puscress. Ffartien:al hMaagsiheer:904)7S1ac8rificedSex1:1 Female row: extrenis ( 8) FCT 30 gpm MacrFoistcuopiitcarByservations: Pacer Eland Mrenal NicrKoisdconpeiyc servations: Harenal KSisdenaehyages Lung ""RCayissteidc wsaassss,, 41.23 3cacad,ia.ft anil alk pst "Hiinghttheadpreernianleaelnlaarregae.d. "Possibly pale "SiEnnulsaorigdeanlenetctoafsirai,ghtcoratderse,nalmardkueedto missive kostinuesxcaimdian)ed,ectaaissisai.ng ""CHiersacnrirchagper,ogrleoscsalivearenaesp,hrowpialtdhy, sininal Precaia, foreign bod, local areas, marked SPpreocjieecst:MaRsather: 21080012 Swit STH Page: 191 355 00743 ISnucainvaireiuzaeld MSaicnrgolsecoTpaibclaatneddMifcnirnoaslcopRiecpoOrbtse(rcvoanttiionnased) FL-A43: Too YeaRrikOerralLiTboorxaitcoirtiye-sD,ncoIgnec,nicity Stoey in Rats Table: 2 fFiatnea:l hMaacdkesr:94I)RASaTcErificeSdexi:n Feexmtarleenisrow: ( 8) FE-143 30 gpa FicrasWcaorpuiaceyObSsleirnvgations continued): PPiatruaitthayrryoie ters F:ireatensns "Bhaaltucetxoacneilneed, not in plane of sectin ""hyersesglarcs, woderate TShpeleefno,lloLwiivnerg,tiHseasrute,s wDeiraery,foSutnontioch,beUwriitnhairny nBolardmdaer,limTihtysr:oid, Trachea, Salivary ase, Fuscreis. FFaotrea:alhbeeetrst96()R-S0a0c1r9idicedSecitn eFxetnraelneisGroup 61 FC-145 30 pp Nasrusceaic servations: Pi[t9uitary Soft Tissues (nck) LKiivdenery Microscopic Oaervations: aErneal Niner Liver Lig Noawary Slant OPaarraythyroid Pituitary SSpalleievnary Bland ""LSeufaltl oyheewdoarrrkh,agipcossliebslieon.besorrhige. "Irregular cystic subcutaneous ease, 6143 2 seannnairnyngelcakndaroera,saploisvsairbylyglare. ""sslliigghhttllyy ppaallee and pittec. ""CAoerrtaitciatlis,vaccaaotlea,tiowni,laltoecraa!l,arenasa,rkedwrite ""DHherpeantioccyptregvraecsussilavteionne,phrdoizdaftahsye,, awiiled Wesatacyte alteratica, basophilic, focal, "hweislcerrhage, local areas, irked "Mbeetnassctaatriccinnoencplase ""NOestt,pxwaisilcaetde,ranlot in lane of secticn -Naedtnoenxsaninet, wissing "Hescsicerosis, woterate HTehaertf,alUltoenriansg,tSitsosmuaecsh,werUerinfaoruynBltaoddbeer,wiTthhyirnoirdo,rmaTlracLhiensi,ts:Escphages, Pascreas. SPpreocjieecst: Naantber: 028108012 Summarized STAR Page: 192 356 00744 ISnutsinvairdiuzaeld MSaicorgolsecoTpaibculantdedNifcaroismcopRiecrtD.ise(rcvoanttiicnnused) FE-143: Too YeaRrikeOrralLbToornaitceartiye-sD,acTongee.nci0ty Study in Rats Table: 2 AFoaitaea:l WNeoeabkesrt1081)R-0T0e2r0sinal SSeaxc:rifFiecmeale Srowpt ( 6) FC-14330pou MacrosWcaospniacry BEslearnvdations: Mersshceorpeniacl Observations: KiLdivneery tax FFaarncrneyssSlant Pituitary "Kiss in Fight inguinal ares appes to be inflanned wilt erst. ""SFienluvsiocidaailneercatlaisziaat,ionc,ortaeirl, waked "HHeeppaattooccyyttee vaalctesrlaattiioorn,, vealcstcildaetreasl,, fwoicalld, "sHiltveeslar mcreghages, wiltifsaal, ile hpeeerniavcaasrccuilanronssoonclar filtrate, aild hina atrophy, soderate "haanons The fatloning Spleen, Heirt, tissces were found to be Uterus, Dury, Stossch, UwirtihnianrynBolramtaerL,isiTthsy:roid, Parathyroid, Trach, Estsbages, Salivary lan. fninal Nasbert 18-0021 Sex: Female rout ( 61 FC-143 30 pon Fate: Gasie. 99 Found Dead MacroNsacaospaircy OEblsaenrdvations: ters Wicroksicreepnisct servations: Liver Raseaey Gland tary PPaarnactrheyarsoid PSiatluiivtaaryryBland Spleen "aisnsg,uin8a1l 7a.re55a w3.l5tialao,tawlaalrtialosbsalirn, right "HLeesfoterihnagsuiicnallesiaorne,s.0.71 1 ca, leit aterine horn, "SHiensuastooipdoailesiesc,taseixat,racnoerdtlel,aryo,decroartteical, "wHaermkaetodpoiesis, extrasedallary, winiaal "AFdiebrrooacdaerncoinnson "THniethiofn pnaoirraprelsiesnitts ""NNoott eexxaanniinneedd,, naoitssiinngplan of section ""NNeott exxaanaiinneedd,, aaiissssiingg "wHaerskaetdopoiesis, extrasedallary, increased, SPpreocjieecst:Maasther: 281080012 Suamrived STH Pges 193 357 00745 ISunatnvairdiuzaeld MSaicnrgolsecoTpaibculaantdedWifcarinoaslcopRiecsorOtbse(rcvoanttiionnused) FAA: Too YeaRrikOerralLaTboorxactiotryi-eBsn,csIgnecn.ici3ty Study in Rats Table: 2 fFrateee:] (Mbaeaebtesrt951)0-0F7o2u1nd DeadSex: Female row ( 6) FC-14T 30 ppn KicrosSctsapnicchQiservations. (continued): eras "He.eserhage, fecal, mcosal, wild alyp The fallonins tissaes were fount to be within rorma Limits: Vata, bert, Lung, Urinary Bladder, Thyrcid, Traches, Escphges. Arias! Nosed IBATI2 Sex Fenale Group: | 6) FIAT 30 pon Fate: thie 33) Found Dead WecreNsacaospaircy GGhlsaenrsvations: LPiivteuritary Mierehsecroepniacl servations: Liver ey PiFtasnintayryGland Sativa Gland SpSlhienen [re "Laariglearraycrorteigcionm.ass, 111 8 x 15 cb, deft "pHielaeorrhagic mss, 0.5 ca Gia. ""SNiencursoosiidsa,l wcilttaisfioac,al,cormtaersk,edsoferate sAclaveloalarr wmiancerroaplhiazgaets,ions,utviidroicaalt, ail -lbadtenceuxsavined, wissing lot exasine, wissing F"Hienbartoossiesis, estranedsllary, increased, "wCytsetriacteglands, marked TKhietsefya,lloHneiaargt,tiOsvsruye,s wSetroemcfho,undUrtionarbye wBiltahdidner,soTrhyaraiLdi,itPsa:rathyroid, Traches, Esopbags, Pancreas. final Noabert 18-0123 Sex Fenale Secupt | 6) FL-L04pa5n Fate: Weeks 105) Ternimal Sacrifice MacroNsacnospaircy DBslearnvdations: Wicrotscroepnicd servations: Kidney "pecryisntesallaargsesmasgsg,ear3sxtoSxbeTianfnlaniened alk throat ares, ""SMienpuhsrooisdiasl, etcatbausliaar,, csoordteersa,tesoferte PSrpoejceicets:Mafsahter: 0281080012 Sanwrized STE Page: 194 358 C0746 nSannrzaat NSirvalsecaTiaaclaatneddcrriomsesretracttiionnese REST COPY AVAILABLE 18 Teo teFrirralLiTareactohrniecs,erIci.c30 Say in Rats Tate2 Fwale tYhais10I5 ETErae SSruiieclee Gra) FE 0 pn [ os a -- Fairy St iSesrlcracisrioenr,lipnititoh,yinal okriyta Tieotea bpeshate, trate Jr Tpreaselasihaart,ewsatrtrsal pill, erie SShietewia,tronLEiinnltg,,iesPtsaescsisSe,eocfounritsoarbye Hwiatahisn,seTahylroiLd,itP:rthyred, Tash, Esohges, Faiitem tNeahr105I) TIrea SSuartfiFceens Gro 1 F110 00 fr Sal T-- easing raCtae.d stosting Filed with insets in fr Reet -- SCiorntiacailagesneertast,ionc,rftec,al,il44 Gown alnictspsreoaglrasaetiieons,riapntlh, sninl ue pPiotrtaall wileidicet prcaollidfeerabtlitn,ati,lewile RLwasisyseSint p"ilcaalsa,parrelaictaitvei,o,simsitnsal ok amined, isin Pvaarrysbysie Sul Tstine Tlaetleavpner,sleatiai,n dshiante eof,ecwtiiloen Leiowonrans, jinn Ldiengnetien.ilriting unr ith onal srface winwey Hater Ae avait, wisi Shieewf,elHoutn,tWisastes,sSeteouftou,nTtooibte,witThricnhrs,eaEcbLuiets:, Selvary lan, Pancreas, Pluie. FSargcet:oftahtr: CBEEOIZ . Swnwize ST gs 12 359 00747 . ISnutmimvairdiuzaeld MSaicnrgolsecoTpaibcslaantdedMiMcriolscopRiepcorDt.ase(rcovnttiionnused) Riker Laboratories, Inc. 30 FE-AA3: Too Year Oral Tosicity-Dacsgnicity Stuty in Rats Table: 2 RFiatoes:] (Naesebkert 901)0-0S1a3c5rificeSdeai:n FeexmtarleenisGroups ( 6) FC-14T 30 pon PacraPsictoupiictarGyservations: Microscopic Bhservations: HKiadrneenya) Lung Fitsitary "R|aised red mss, 1 a dia. ""sDidneuosnoiizdaplroegcrteasssiiav,e caaerpteora,thiyl,e i2e "PVealsvciaclarainneerearlailziaztaitoino,n,ainaiisladl Hesorrhage, wiltidocal, ail "benom The foliceing tissues Spleas, Liver, Haart, wDeurrey,fouFnadmatroybelawnitt,hinStnoowramcahl, LUirniintasr:y Blaster, Uteras, Thyroid, Firathyrsid, Tacha, Escptagus, Salivary Eland, Pancreas. fFiatnea:l (NMeesetkesr:105()RTAerTminal SSeaccriFfeimcaele Geass 6) FE-143 30 pon Pacrascopic Dservations: PiRtassuiatrayryGland Ficrohscroepniacl Oservations: vidney Liver Lrg Frrathyrsic FtirtianiatrayryRatder ""HSeuuacllrrhsaagsisc, masppse,ar0s.6tocabedami.lk cyst, in trot ares, "SNoitmustoairdaylpecrtsalsaisai,a, Cocrotretse,s, awcacdeerrtiete "DPierlavniiccignreorgarleiszsaitvieonm,priosnaathly, sini ""pVoarstcaullaranoainnaecrlaelairzatcieolln,inmfiinlimtarlate, winieal "HNeontceerxhaaagien,ed,locnaelt airneapsl,anseodoefrasteection ""NAotteexnasined, aissing TShieleefno,lloHweiunrgt,tiUstseuruess,weOrvearyf,ounMdastaarybeSwliatnhei,nSntoorwmsaclh,liTnhiytrso:id, Traches, Escphages, Salivary Bland, Pascress. SPpreocjieecst:NRuastber: 0281080012 Summarized STAR Page: 195 360 00748 ISnutahnvairdiuzaeld MSaicnrgolsecoTpaibclaatneddMiMcaroaslcopRiecporDti.se(rcvoanttiianrused) FE-143: Too YouRrikreralLaTboorxaitcoirtiye-sD,ecIongce.ici3ty Study in Rats Table: 2 fFiatnea:l (MHoeasbesrt1051)0-T7e2r7ainal SSeaxc:riFfeimcaele rou ( 8) FC-163 30 psn Pacrascosic Ghservations: Pisttuiirtary Faawary Blacd Kicrehsecrsepsiacl Dseations: Kidney Lung rasniry Bland POvaanrcyreas [Piitsitary ""hhaiiisedLosdsarkonmhasesa,d a0n.d5 nceackd.ia. "Maasrse,as;43m3ss,ca, rcioghctiaan,xilLleafrtysaindde,theaat ""Spienluvsiocidaailnercatlaisziaat,icsc,ortseisn,imamlarked "vHaessccurlrahragew,ineiriafluiszea,tiowni,rtweidld "Fibraatences "htiysnt a atrophy, aiviml ""Chyisetriacrglands, warie The following tissaes Spleen, Liver, Heart, were found to be Stomach, Urinary wBiltahsitner,newTehaylroildi,nitPsa:rathyroid, Traches, Esophages, Salivary Bla, Ere - final Naber: IR-0128 Sex: Female row 1 6) FC-143 30 gpm Titer heres 60) Sacrificed in mtrmis MacroBsacgaasaiecn sienrtveartniaoln)s: WicroMscroepsiact Dservations: Hitney Live LRuesnegntary Pancreas SPpitlueietnary "aasoninal cavity Filled with blosdy flues ianevsoelnvteadrywiatnhd scoatsatloarr,exgtraennssliavreltyissae, possibly tuner or chronic nflamsation. "SCionrutsicciadlaldeegcetnaesriaat,ionc,ortfeosc,al,aileile "PDehtraasnitcatipcrongeroepslsaisvee nephropathy, wild Pelvic aimeralization, sild "HMeeptaatscteayttiec vnaecoupellaasteion, wultidocal, wininal "Haesvcaatloaproieasiimsr,aleixztartaisoend,ullsairlyd, ainiaal ""HMeestoatshtealtiiocsaa,vpmlaalsingnant -"Mhetsasotmatic neoplase PSrpoejceicets:MaRsahter: 2810R0012 Suwrized 51 Page: 157 361 00749 ISnudaimvairdiuzaeld aScirngolsecoTpaibculaantdedMihcorioasaclopRiecpoOrtbse(rcvoanttiionnased] F143: Tao YeaRrikOerralLaTboorcaittoyr-iOesn,cagIencn.icity Stay in Rats Table: 2 AFraitsea:] MMeaedkesr:BA1)-1Sa2c8rificedSexi:n Feexstarleenssrou (6) FC-14T 30 pon WicrSatscoaupsicchservations (continued): UUtreirsuasry Batder -Nuetctearstatic nesslase ""EHyesttaisctatgilcandnse,spilalsee HTehaertf,olOlvoawriyn,g Mtaisasaureys Gwlearcee,foTuhnytrctiod,bePairtahtihynrociod,reTraLcihietas,:Esophages, Salivary Shand. Ffraitnea:l GNeusebker:1051)8-0T7e2r9minal SSeaxc:riFfeimcaele row (8) FEIT 30 gn Macroscopic Bservations: PiNtaunaiatrayrylast WierHssacorpeicl Ohservations: LHiivdeerr Lang Nasnary Eland Parathyroid Pituitary ""MSualatlilroabiosleadr faasrsk,ma3s.s5,x1 3caca,diai.n right wSilxlsb;rlardgene sinslttielnotblaarreanss, "SCionrutsisciadlaldeegcetnaesriaat,ionc,ortleosc,alodareeraast,esoderate ""Fpoerltvai)c aseinnsenruaclliezaatriocne,llaiinnifnialltrate, wisinal "VHaespcautloacryteainvearcaulailzaattioino,n,w1ul6tifocal, inial Presscnia, interstitial, chrnic, local areas, Haelsearrhage, ailticocal, siniual FiSrbarnoualtoennsc,nswultifocal, aild "FNiettroeaxdaennionnead, not in plane of section ~hdences STphleeefno,llHoewairntg, tUitsesruuess,wDeureryf,ouSntomtaochb,e wUriitvhairnynoBrlsaaddlerl,imTihtysr:oid, Trackes, Esophagus, Salivary Slant, Pancreas. PSrpoegceicets:MuRsatter: 0281080012 Suanarized ST Page: 198 362 G00750 TSnudnvavriiczuaeld PScinrgolsecoTpiibcuhnatdedKtciroaaslcpBicsSrbecrtvtiisounesd) . FES: To YeFritBealLibTooriacteirtiye-sQ,caIpce,ici3t0y Stay in Rts Tale: 2 fFaete:t aNsahsee10A) FTund DeutSe Femle aus (8) FOU 30m FasroRscaoniciDlsaenrtwtions: tTiy 2l5 la, srlicgehrtataendllsaicueptiecs ass, 4 x awhintesFlsuihdi,n,in1.l2eftai6ngu,inalFiled with lly Hereswcroesset Oserations: rena tity tir Fwagnwry Slane Spltseitary stes ht ates lage. SCionrutsiicaclaldetgeamesra,ticnc,artleorc,imaarrkeeasd, moderate "Wharwariaclzpartoigorne,ssiivsetesrspitritaayl,,ar41t4i, Fwotretrailteasmonsclew cel infiltrate, 614 "Ncecirtosairs, iwnaelatliifezatli,onw,ildsirinl eSsisiscrtcceilnson h"eiutseoniesis, extrasolar, increset, owlilye Treitf,olGluwairn,g LSitosnssecsh,weUreinfareyndBltaoddebre,wiTthhyienide,raPalratLhiynreosi:d, Trache, Escohass, Salvi Bin, Farias, FPuienli whitse9)EASwTrificetSein eFxetnrleneisSas (8) FCI 0 gan KurasNzagikcaOBaleirnndations: Stulwl Intestine Micrroesacl Oasrvations: tLiivtey ng "FaCliercmad asilisg,htl3ycoenflairng,es.in right wills Sees of slceation with shesins. "Ceoortsicaflerovsaicss,aladtiifonf,e,thcuorsti,calw,de4r:s1t4e eHraattaecntreesovrisctsioolnatiroanl,etdisf,fusmer,kewseed "WHaalliiggunasntt phoonwss,, hhissttiicoecpyttiicc Melsctsis, local ares, il FSrpeijcntsWaaster: zBICONE2 Somnrined STH igi: 199 363 00751 eSubnreisnes mSiaiorgrrcLTnsearatMadreieWbsr,ianTdses,RepBtrecroanttiionnenst) Fe5 To You GaToby capita in ats nie2 rFise easees0BTSuLifcetSuin eelreesrot (8 704310 pa WisfserBearetoen (contin Fan Et sSii}grnoestopnhen, isticrtic [JeenAser ikliningaarppneonnh,,ebmisstiscrrttiicc Stary sis fWrpinn Inshon, nstizotic SfStuholenlrerase i""tieeeg, hmmeipdconh,amlsetictic Vinay sate lt Its mirc heersf,llTnoig,tiPsaeswtea,funrditseb,iStitnao,emFtliitsa:, bart Ffotr tNhara35BSTursticedSna oeeesGr {8 F103 3 an [ ihairyy a fast wre [rrtEen -- ity te wn S"uWEatnoc wa,ast, 04.5chafih, sity a epi es nad giinreeTiangteidnc em3ea1, 1s+0rc3e3fcaaLpitasatyritghet, Aiwngiihsti,nr0e1acla dlianrge Lit sre ale rs wll 1 met, . T cCiratnp ,dgaerwasp t,on,i--sseeat-- ds yi saansb ,feaerbaa rbi,onifeoal, ale eartoos,eist,ilp, sraian 1, 16 AANbniaatlatisrraeotlisaeetsi,on4, sind ap Species: Rat Sie 1 1g 00735624 Srainincaat Siirkcae LTpiiulramiteeatsMI,iireToe.srht acotnitinn) FT Yeu BaToit capt Sa io ats Tae: 2 iFile tiaes 95G) ESu?rifceSein Fstlreeesa (8) F165 0 on rohseseyBGrnadtions cntired: SFietritiy sFiirraotteiionns Sseetsetnsoieis, extramealany, incrise, wie oThier,eWoenr, iDsusruye,s Seroecf,onWitneedye lwiattheirn,meTrhyarsLd,itP:rthyesd, Traces, Esshses, Sis Ew, Pues, Siintd eNaitt119I) TTeTri] SSuetriFeasle Se 1 FL 30 an fo -- WcrKosirctpeeisac Drutions: tlo e Pitty xo visible esa. ZSiensbitailnrcaltsat,ionc,ro#n1,6 sofeate SJvevpeilataetrotsrsamiepclaaigantetisio,orn,m,taiifionafll,,6wile Savon ThSeatetfnea,,labSraor,biaGssr,ueessS,seeOeeyyf,eSdeanmtseoyPberhweaittsh,i,eSsteroa,LWiitn:ey Bader, Tyr, Pathos, FFliemtKaatser99BSScrificetSe1xs tFreeentfro: (6) F165 1 an herFoiets Gratis: Rawr Slant Wersteropwiec Denti: LRiovaneke last Fiuitiry Hteinccrigaiacna3t3l3as13eesn,in162856i9gn iwbry stigply ae. SSaitvcarst svaectast,iocn,rtp,eriwgerttearla,testrate SLeovrriaew,pemrliaitse, )ostwiice Herons SPrcanesaabtr: CBGONR2 Sncize spe 565 C0753 nScndnasl aSirnoe sDieladteddMMeirnsloBnsrBtarcaotimoinns) F5 To Yeir rBalLTmeaot,aTep, c3 Stay in ats Tae 2 Faaaeh eanvees 51StifceSui Fwreenisss {8 FL 36 on MicrosSScoiopei:c Dbservations (continued! iH- ics,ierweisnst,oaw,rieadte iToetfnlSoe,seeehs wGrueryfenrd tyo beBaatihe pTari,LiPtr:thyrsd, Trchs, Esbsin Sivan Si, Frere. Fointet eoee50T) SSicaSeir rFaees ro FR 3 0 rorsasry GEeis tions: [wareen -- oFthenotraeid a I "aWrie freietea,s,ri$g5h 8si5l1ls48 ca, ented FaGlreasteeasw0en125Tocehs.tin 08 sills, SSoarnttaaalsacttiiion,n,cofarln, 1i6tt SrSaeaaesiiaensriuzkesiin,osnhowaeonfdisti Feiermrie Aieenean, inns, tSTheoafnyesSoee,HSoasaetrsaea,rreyFo,rdSeeet,omSan rietasirsyEsBonmealr,LisTtrs:oi, Traces, Esptues, Fott tNeatve1631) TSrial SSevrFcoe Gr |)FO 9 Roses Surtions WerosTceapc Gserations Hjoits Tse Ho visible sons, Hreptnocye tteation, veate, fects Saeoeenine, sissig Jot aie, see FSpeaciees:WRaatrs IER samrized sg 2200735646 EST COP AVAILABLE Snuenriizles RSrirnegelrsecLTpgicbrlaat4to3erdsReni,isacIlraes,Rees1eBtar(acotnitoenst) Fett Too eu Dal Tonicty-Gcapeicity Sad in ats Tie 2 fFiaten tRohsses169T) TErina SSeucitFeusla roa (8) FCI 50g [---------- STienef,ollioitnyg,Hibsesrets,eirge,feheese2,dDeeiryt,heRosroyrltiint,s:Stan, Uicry Sater, Kirasl, Tras, Epes, Seley Elune, Pacres. Fiiaten tNaabher109S) TTrica SSaeritFiecmeie reat |) FAG 30 gn RarsistcaprcyBaeations: Haar Sint Werecraeiact Shartizs: Vite pwene Hove se siHtuatrtyion, Sfitheu we Raai,sed2mxss0,80f4n81tpa.ena wes can, ta i pn ve Shri rap pes sip iat, tn HPeelvsicsseinasisestiictn,, apiiedga le LFe isrmtrrsoniete, Kh remit efTatrbuelaanrihnypterpilassias, bilateral, woterste Stieatlsveaintiinse, eaeine, ats STleeie,tweisr,sBeuancsh,werberifneedB8atBte,itThoersa,mlHelbineti:, Trsin, fia. Fiisateaarret120T) SEurificetSe8e mFebelesset 1 FI pin srpehee Bsetize: [wIren!-- Seen Vigne "rrigtsaettstee au, 9112 5 cr, i 6H stem sist ares "SCisrstelvecsalsatai,n,calroecnal, warceesa,tewetiate Fkelladrsiharmprealtianstai,on,cosries, fecal, erate rSepjaecst:oatthr: EBERLE Sanwrizee St Page: 25 367 00'755 Sara ire ive LTialatetaoarloec,setBemeniinee FE Te You Bt ee once Say 0 ts aie2 rHee ovanrsio BTSSoiSwseeniesrn (0 FE 30m sajira Button poets Sweette sltwation, shi, fl, hT-eirr S04 pfrryruipen-- eg, p--ate--sti TSSnane rTererstsyei,nfeea,lwyoue,atsiatee B Ti eE pg essrwer Fshbe EwanR, ePtlss, Techs, Espen, Slvry Slt, F Tst 30T%oe vSeitrets Sogn Fn oar ies Troyy tre litiboebuamtwes,e055 1045 Sie PFoyem om P tp ern r Rv -- i ert iter tHieteisv,wtderamicdrEaats,rattiirv, wd ur ATevaepvprsoetcsyo,ntsb,nbelwlpdree,,ibl e syrtiot SJpenustnss inspena csos aea, ie an Tavoryiesnomcmraistwtdscation, ee H--enan, writ, rests fTh eiown sm es wre fdg sb itn d er Lins:A -- Seisn:eart s ocr 6 Suanarized STAR Pa*g: Y208 o3oS8 SInndairviidzueald MSaicnrgolsecoTpaivculaantdedMidcnrioasaclopRiecpoOrbtse(rcvoanttiionnused) FE-143: Too YeRairkeOrralLabToorsaitcoirtiye-s,DicIongc.eicity Study in Rats Taste: 2 Reinal Neaber: 1ATIS Sex: Female roupt ( 6) FC-14T 30 gpa Fate: (ests 105) Teruinal Sacrifice The fKoitciroonsicnagpitcisBshuseesrvwaetrieonns t(cotnotinbueedw)i:thin noraal Hisits (continued): Salivary Bland, Pituitary, Pancras Ffarties:al gMeasihser:108I)-T0er0sinalSeSanc:riFfeiscaele routs (6) FC-HAD 30 poe PasrosRcaenpiecyQSshearnvdations: PicraSsceanpiac: Gservations: KLiitvenrey Lung PPaarsatahyyroBildand Pituitary Thyraid mass, 4330 aa, bn pineal area, "SWierduasloliadraylceelcltashiyap,erpcloarstiea,, amoudletriaftoecal, ail ""PHeelpvaitcocyatienearlatleirzaattiioone,, vaiilcdwlate?, wile "WHaesscaatloacrytseimalrtaelriaztaitoinc,a,baesiglkeilic, aild Perivascalar asonuclear infiltrate, wile ""NLaatbuelxaarmihnyepde,rsmloatsiian plane of section ""Ubiietrioenraanchial cst The follaxing tissses vere found to be within sereal Linits: FSpalrece-se,as.Heart, Uterss, Dury, Stomach, Urinary Bladder, Traches, Esophagss, Salivary Slant, Ffartiea:aleosnidesr?97IASTuLricedSeixn mFaetnraelneisSeaust (6) FE-1AS 36 poe PacrPoistcuogiitcarOybsarations: KicrosFcaespniacryDaGslearnvdations: hiitrhenea,l lisg Pa arathy] roid Pituitary ""RNaoidsuleadrdaLreksiomns,s,1 1c.a3icao,dai.t perineal ares, ""SDihnruasnoiicdaalroegcrteasssiiav,e cnoersthevxo,patshoyd,eraetiele "scalar airalization, sina -HLeosbcurlrahragRey,perfpoclaals,iaail "Not sxanined, not in plane of section ~henons The fallouing tissaes were found to be within sora limits: Spleen, Liver, Heart, Uterus, Ovary, Stowach, Urinary Bladder, Thyroid, Traches, Esophages, PSrpoegceicets:Naastber: 0281080012 Suanrizet 518 pages 205 369 00757 sais ms 0038 10\ ANUDE eSuainirisueld MSiiancagrlreesLTaaipbecla1atmtaerdiMeiisc,grsosI)cnoc.ppioer0Btse(acaotniioounesc) ~ Tae:2 - Ft#ninal henNaber: 31)R-4ST4a3ridSexi:n noes Fesale Group: ( 6) FC-143 30 opr [EKraPenn-------- [ Seba n-- isi,-- arid Ge Sireatntse watt, prt], ete wi SeSmteitesa,,siseaantteiiaeftdi,oin,ew,6i1e2eal ares, wile Fnoeiye Blt Finiavsero, ite CHeiinsnryesfate rStainveoinnsatberaarcise sige, ies, ize iSieems,eairntstDsusye,s wSroeutfhondTrtoaebe,wirthaintshor,ed LTaitnet, Stages, Stiay Shin, ti. FCirniNeae1eFAen tedSer Foe Gro |) FI on PpOe -- Grnt [iLr tner ---- --r-- Sietety AaH{,eept0i5i3tar7.ie5o1w4m5ecor, b1loowtcoi JsaCks3illaehrSuisagh2hatltareguebe, fcieTso,es0.1 rHiGeisasriin coieel evs 2 ales in Ha ---- Geraanseerepsetsiovne treaty ain fertswoitrni,enteLyrcesariens,tuird aren bighy woptiintytis.,liydeaaiseec.tionRte os Soenrtoyasts, eareeitiay, resd, PSaegeetsNaatbe: zsn2 pA sre " 371 Too7s9 ISnairti,s TsiolrRe LETtt8rsBr,RsIeE.be3B0tacsonitein et es ter Bl ToiSci tay in Bats nie1 FTere kNeor 8BFWos tdfs oe Gras 6 E10 3 0 Microscopic Dsenvatiars (continued): ol iEThvenrfiWt,twySvatsreaerEiawreyr,,FfaaSnrteio,,eswairhy Bearer,Liesatl, Tors, Prt, Tras, FSi rtwaahr15B0T0ern SSeacreeeal Sr (8 F005 an [ iwrny is SRaunl, rSi1e0d0rkcnweon, p6r.4ioco)iwe WaprrsraineBatis: SXlicmiiel,iaa,igcarte, rte ies rPeilti oeraesetons,tSr16at, wie [ arjaelrast,parmtib, va6n, stil, hbarir lg S"BTaisllrirpoweerasshgee,s, wiithdt,, s4ite [ree SSeidson col tk ins ste hteef,lLlntFiittss eeretfy aonti iatkissSrel rnihse:i, Patho, Tries, Sines rd, Pree Petas tNhearr1BSAacrificedSwin ereessSr {8 F405 an [rhWeyn-- St Gtouogerwitha01ecrxess, a, itt [ sien -- Eiitaittweotk) leKoewwnes SFSiaessnasalosavlccstataii,eon,c,orstiei,tni]idl, wis oetrovtae sltraitioon,ni,e,sitmioist,s, nan rSpeaciees:oRsate: E62 : Sunwin st pg 20 572 0750 aris 3. 076 SSntsd RSilaeerCaelatsreaetsiralmeetBacitor E15 To vo rlToe Sic Sts 1 ts is 2 CFeT tae Susie rieeisog (170 0 J(rOetty-- GEi} nnde oart2 1311T2e10 cn oe viELyTnwthoes lt, 14 tas rcs he ies arse Brion: Sieys 4s rs se fl on pas SAeatiiebsteswaiicrst,iewnkd iiw Srconrnstmeorrtiaoanstbwaybei,e,swalwdeic wr Seweevaerieiltw,e osidte any tut Sfprsriseen Hhreetars Sofrpnws ws JVoiensey ater JEirHetveegnunsad sve al wen, eIsttontsWaens,soree,ctenh8 ithiyn srBel,LPt:s. Fiie RsSBtiec wFoiiesa 6 FA orFciot BBairtation: SA vrhicawst1.105 dn RVtroow Sati: J reaenersiagoens,-- sowib:a, die Seecsiesebrt : a2 . `Suswarized STAR Page: 2160 0037762 Snainnia TSiivgcee CTeolraetaierasToe,B.irrt acointninsent RAE Tes tor BlTesh Sci Stay in es nie1 Fait nhes80B ) Sis te 0 froeesGags 6 E10 3 0 [r(#e4 ---------- "sarlea,sswliosatiwoen,, i41d6 JNaert Gd KSiuraoenie TtSheenifsl,LuoSrtHiyttsBaLreee,e,Funearyntc, bSoEemiathSi,ietsirnlyiBiasrs, hei, Parathyrst, Traces ruteas tNhaere,10Fd odSe en ros (8 F003 10 pn heoaswiacy BEekrtie: AStigeallrouns,alt0.o51l2ac,a i right [eriysa-- . u6r57,30k3a,t finn.righ wile aNrrea Se eSmNiacnwaacriioioadntiat,scctro., ie ray fron sLirty Sfieapciiaalrawdgaiirtiseanerd,,w6ra4hitiicfcril, are 16 Rlyay ia FSBhhiacnatealecsl wean 414 Hneetahtreit iAFreoiwnranat asin Ji[ Teltwihtoe,, awseiend Sheief,ollrwisn,g Hrayne,s wwrke f,ountitonybe Bwiathiien,rcmhesn,itEs:an, Slvr Bl, Press FSiane:Raate: 82 Swuriesst pg 20 579 00763 dSuinvniadruizaeld PSiInFgElReOpTaIbEla4tdedRicgraolspifcorOtbse(rcvoanttiionnusnt) Fe43: Too YeaHritGealLaTbooriactiotriye-sD,ceTpcn.ici3t%y Study in hts Tale: 2 dFietien GNeaeskser 21)47F5e1ud eadSex Fewale Grow C1 FCI 30 pn HarssRcoarsicasBelravnadtions: [Yeidtpey e---- siLes Sl stonch "Swoialtlisnous ass, 1 5.51 4.5 chy right P"ealsvciaclrminaeirnaelriaztaitziaotni,on,siwnian}iil hFeinratoompaiess, mtraseullary, incressec, ewrrite LThievefr,alhoesairntg teirssse,s wDrurey,fouPnadntaoybeBlwiint,hinUreivraaeyl BTlaisttesr:, bieesal, Taroi, Parthysid, Tracts, Eephges, Salivary Ghn, Pituituy, Pancreas. fFaatel hNaebeors051)0T5e2rinal SSaeccriFfiecmea Groups (8) F143 30 pon FacrsFsicipticirOynarations: FireKsezrziecs Oserations: tidney tuanrgy Fiptasictearsy "ise hworhasc ais, 0.4 a di, SNiemtulsairdahlipercstlaassai,,cocrotret,e,mowdseerraattee "PDerlavniiccspsreorgaleiszsaitvieonr,etsrianpntetdy, 14 T"ysstt,ebrilastieerralaliation, si1 pTeorupdlsarshipse,rsilsalesta,tebli,latweirladl, asterate "enon STphleesfso,llLoisviern,tHiesasrute,s Uwhreerasf,oMuatnoybeEtlahnidnSmtooircahl, LUiriitnsa:ry Bladder, Thyra, Parathyroid, Trach, Escphages, Salivary Shand. FTietaeltNhaebteer:10S90T5er5inal SSucerifFiecweale Grog (6) FCAT 30 pon NarFoisscpiitcarByuervation: hsaiinry Slant S"ahliarrgTeedswithbsema,ll dork lesions, 0.2 cn a. "Loita ass, 41332 a, in perio ara, sPpreocjieecst: aabtr: Z8IHOL2 Suanized STH Pug: 212 376 00764 Scamrized Individual SBaicnrgelsecaTpaibcalaantdedMimcnrinoaslcopRiecpoOrbtse(rcvoanttiionnase.d) F143; Too YeaRrikOerralLiTboorxactietryi-eGsn,caIgnecn.icity Study in Rats Table: 2 final Meader: IR-55 Seu: Femle Grow ( 6) FE-143 30 poe Fate: Meeks 105) Terninal Sacrifice WicrosbcroepinctBservations (continued): LiKvigevrey PLaansgniry Blase OPirtuyitary len "Si|nusoidal ectasia, cortes, wild ""Fpoerltvailc asoinneenrcaclliezaartiocne,lluniinlfaitletrraatle,, wailreke HPeoprtaatlocybtielevauccatlaptrioolni,fermautlitoinf,ocaall,eaild Hepatocyte alteration, varslate, aild F"isbcraalataerroanisneralization, aild "~hTuebrsclnasr Ryperplasia, bilateral, scterite "Not nasinet, aissing THheearft,ollUotweirnusg,tiSstsouneasc,werUeicfaoruyndBtleattbeer,witThhiynreiaec,raPlaraLtimhiytrso:id, Trach, Escphags, Saliviry Gland, Farereis. brine! Noabert 1-8 Sex: Female Groups ( 6) FC-14D 30 pon fate: heres 109) Terwinal Scridice RsresTcaospuiarcy OSelraungtions: Microastceoapniacl Observations: Kicney Liver Lang Nasuary Slang PDiutruiytary len "LabC}lated ass, 83 63 3 ca, in inguinal axe apwesrrienteiacl aanrdeacsystaisc.s is quite "Sinuscidal ectasia, cartes, aoderate "wFdigeereantte, conv. tub, epithelium, brow, "PPoorrttaall bsiolneenduccltewprrocleilfleriantfiiolst,rataei,i14 HHeegpaattaoccyyttee avlatcesrlaattiiono,n,vamcuuletliaftoecda,l,wialldd vPaosecwuolnaira,wiinnetrearlsitziattiiaoln,, aild chronic, saltifecal, Aallvgeslar macrophages, wltidocal, wild "Hdenccarcisons "-Chyismto,mswilateral "hseondaetrcaptoeiesis, estrasedullury, increased, HTehaertf,olUltoewriansg,tSitsosmuarcsh,weUrreinfaoruynBltaoddbeer,wiTthhyirnoinda,rmPilaraLtihnyirtosi:d, Trachea, Esophagus, SPpreocjieecst:Nfuaatber: 0281080012 Suis 518 pug 25 57 7 C00765 ISnuainvairdiuzaeld MSaicnrgolsecoTpaibclaatnecdMifcraolscopRiecpoOrbtse(rcvoanttiinounesd) FE-143: Too YeaRrikOerralLaTdooriactiotryi-eGsn,coIgnecn,icity Stay in Rats Table: 2 FAaetiea:al (KHesehss105R)7T5er4sinal SSaecxrifFiecmeale Groups ( 61 FO-145 30 5p The Microssapic Masrvations (continue): following Lissurs were found to be within aoraal Hinits continued': Salivary Slane, Pancress. final Maher: 1-55 Fate: (Heske 105! Ternizal SSaecx:rifFiecmeale Gros | 61 FC-1C 30 gon Nasroscopic Dserations: NicrFoistseapiitcarByservations: horenal HeEasrcpthigis tigsey Liver tuLunrg y PPiatruaitthayrroyid TThryarcshieta "Hessrrhagic ass, 0.7 ca da. ""Sliantuseoxisduailnede,ctaasiisas,inycortes, soferate "Mwyiotciafrodziatils,, aOilronic nonswpative, "CPxerlavniiccspirmorgarleiszsaitvieonn,hraoisladthy, mines! "Hepatocyte alteration, basophilic, foal, awlivleeolar sacrophages, focal, ainimal ""hTautbuelxaarnihnyepde,rpwliasssiai,ngbilateral, derate "hhdeetsoenxaanined, wissing Not eran, wissisg SThpelasfse,llotneiregs,tisFsauwessarwyerSehafn,ouSttoorcbhe,wiLtrhiivnarnyorBmlaalgdeLri,stSsa:livary Slant, Pancreas, Skin. PSpreocjieecst:Muastber: 0281CR0032 Somnrized 51a Pe: 24 378 C00766 Tissan Invstary Tie:3 F143 Tas eur Oral TnkiceirtyL-iDenroagteonrciiet,y SItnca,dy 0in Ra=OnteYsou Inter PSrcojieect:NRaatber: 0ZBCRL2 SoRV eRGRruRpEKRaReI :RACRORNA0RTI pRRpRRRRRI RRRRAR IL MAB =T553=53m5I5Im5I5mI5T5mI5I5Tm 5I5I5I8T5Am 5M5M3M5M5Nmm 5C4aN8nM4Le8 Tsun hae So R1R17N20R27A77R35N43N46R50R51K59R66R70R75R80F78E82F85F88R85F00E01F08F10E20 fworreant F L err e eee ee boraeinharrow t Lana na nan s nn ErEmeages Heart OCLOaOOLRIPPPOPORIRPIPPIRORN KiLdiereey Intestine CL e N Lwegr J ---- r CS rirtiee tiL etate istiL orr ioicor Ha[u=ry Bland pucress S GL EU La In TI nNa G FFiruaittyirry restite CS S eccre ceerr L arice iccin L aacee iict SSnaaliilvarTyteSsatnidne Sint Cord L L aani nRRn N aRnn un SSptloenenr Testis icons LC c er e ar nn ae l TTrhiycrhoeisd inary Batter L CLeArtLecoa iraraoi irerirn eiiren trheres ece Nesntary The folloiog tisuets) I wDreItIot MreuIirIedTbyIprIotn oTcolI<f-IroeIoeemIemeIeewNeeaNeee A8iinntiiccaatteessonhlatya4 odinsdgaaognuiassaics coondmee.ntAwa-eiandniec,atePsletahsaetvroefear g0 teheasSicngoilnensaebdlawitsedwaMdi.nl Tissue Iovestory Page: 215 feport. 379 0787 Tis Tovar (coninont E03: To Yu Gea Trictherr-LOcaerprecsit,y STct.d 3in0 hts rvoasetaaet : anc Tole: 3 You teria SroTneainpn am: NO0L il ars Giains 1f3e3i1t4o Those ae Sw PEEET wpSrroet ren aLcense Garoetan Lwvaaann rLieer nation wwvanan waLyrhyNSeioak ntec) Lvwansn bay wal PPtetirtesyie tarenes ta SSSolilytCerfttlrnse OLwOaOaH SiSoenw svaan TTTrreiaodnstis Cwaniaa Vrrasy Hstr wainl BYHnetrman Tht fllnog Hissar] wtberens4iessFerd by ett ommeseremse nar ni 4 inniicaatns tshlty 3 earpnicws caonmeetA1 inaditcatesPhets rssogae1ntseoSicreomTntls ieda Rprt, 380 Tone Iveta Pn: 20 00768 Tissue ventory (continued) Table: 3 FE-143: Too Year Gral ToxRiickeirty-LDanbcoorgaetnoirciietsy, STtouc,dy i3n0 Rats - Doe Year Interia PSpreocjieecst:Nfaatber: 028130012 TissueMare aerenal fBoorntesMarron Brain EEseophagus HKeiadnrety Large Intestine LLiunvger NLayssagahryNoBslean(dasenteric) tury PPaarncartehaysroid Pituitiry PrSoalsitvaatrye Blan SSupaitnlalICntoersetine SSptloenesnch TTehsytriosidEpididnais UTrriancahreay Bader Uterus commen Th SNtesienntary Ureter Briaa] following DoTseIGUrouLpTNLasEe:IFCE-1I4E33I0E0 Ipab. IIiIiinny aber =RAmmRmRRRRRmAmRRmRRnRnRnReRnRcRoRsRoReAeRnRn ISISTSISISIbIbIbIbIbIbIIbIeTbA6M0MbM0M8U8A6N4MLb B89901122223444555464777 Sex NN8N9N2N8N4R3N7N0R2R6N7R8R2R3F2F2F5F6F4F6F5F1F4F8 CFhecrrehrcehrieirceheistibaaetatieacieisieiaiaicsy S Mabeee teetar siisee sianir iiiie C Craer errei rrbbeib reteiaa iiincs FS aere raber sasb eesei ania iiiin iey FLeEeEeerebeartaarteareraiaseaiiriia ich FC AbbA e barr i erce eb sate a aaey SILI n i iiiin iiieeen eecas CSeerecreccecreecraisiaseieertcrrEiacerEtyr E LidiceresC icecesers tariines S Lieire ceesr aeetr eiaae aiirs iins LFeebtbeieribeeerbaeteeiraeairaanieieraieiaianey EC rrbree rereeb raabai aaaaat aaan FAC barreer seaie anas FDearbbceeearierseeisbiiceeitieseasriiiriiiiinya t3508(5) l were Scti FEQuiredl by proti ocol --oe owsoerems meemeree SLTet Sa A+ indicates tahdiaagnotsis was wade, A - indicatestht 20 diagonrocosnsienst ws ade. 381 Ac indicates only a nondiagnostic coment was sade. Please refer toTitshseueSiInngvleentToarbyulPaagteesd fnisal 217 Report. 00769 Tissue Iavntory (continued) Table: 3 FE-143: Tuo Year ral TorRiikceirtyL-aDbnocroagteonrciiest,y Sltnuc.dy 3in8 Rats = One Year teria Project Nanher: 028100012 Species: Bt Tissue Nase Dose Group Nase: FC-143 300 pn RTR11R1R4RAeinal Noabers a == = 8b8e9b9e0r Su 7F9E2FF9F4 afderretnaal Iceeeen BBroarienMarrow ffreenese EEsroephagus cfoeeeeenn HiHdorntey rfeeees LLuirvgeer Intestine Iaeeer . Lung Lyssh Node tasesteric) Lbeaicees Nanaary Gland Ory cboereeern PPaanrcartehaysroid fceorreeer Ppirtousittaatrey Cceeneas SSuaallilvarIyntBelsatnidne C12 oren SpSlpierealn Cord Cbaornees STteoswtsicshfEpididnis baeeeeeenn Thyroid . Trachea vbeerereen rUtievraursy ladder bfeanreers N--eesemnmtmaerymmaeeeeee Th folloving tissue(s) wSeree enost required by protocol wweeeseereeeeeeeeee tSrtaitnor lill A+ indicates that a diagnosis was sade, A- indicates that m0 diagnosis or coment was mide. 382 A indicates only a nondiagnostic coment was safe, Please refer tToistshueeSiInagvleentoTraybuPlaagtee:d 2A0n6imal Report. 00770 Tisostry oie4 3 To ToirkBelLTtorrysG, Tio. t30 Say in Rats SPreactne:r: LZ oP u rap am: OT NO 0 pn T [ERR RERRAERRRRERRRRRRARARARAR iii 3TBi1H33131T31e32533E51a31033153T85s3103435733805803008108248443545708488 ioe ae Sor RRRRRRRRRRRARRRARKRARRAAN Snharon enmnnannnann Homans eennnannuiin Lise ntetine Lawoayoe1datric) Purses saan au aananLn aaniy Crerierrieratreitaeeiene Sl neste Lena TTriedeton L cee naa nnn inn ana in rary baste Lanaanananaun ccc he follnog tise) we 8 reid prota omen iLrtther ekeSannet S TC I I II I yLWonhtNdoyoh Ganoircail DI TIIDIIITII IINIINI ININT RAC+iindniiccattess otnhalty adsiangdnossrisshwacs oat a ad, Flv made. A -indicates that nroeidr i1ia0oghrnoSrooicsovgmimeeTsnratlwiaaese:dsadM2e1.i9 l eet 383 00771 Tis Iter int her dni, 1. fom EAE Te Yo a ec Sot ts eropeears cncEz J ri ft pSEiIrt Ttnoee nhcyen EShi fToee tae foi te Hos [OR -- sMB ae at i trrrfrrsrrrnrtatantngant s HH HninT Nn nnh nT IEa nEGN EMH HEME ennai n S C ap ll i n es S Radononmeeetm adnonttecal C mas i he TeanSmerieast icvcor7t,72 A +indicates that a diagnosis was sade. A -indicates thatnodiagnosis or comment was made. 384 Tissue Inventory (continued) Table: FE-443: Tao Riker Laboratories, Tne. 30 Year Oral Toicaty-Dncagenicity Study in Rats Project Masher: 02B1CRO012 Species: Rat Tissue Nase forrtesl BBornaeinMarron Esophagus EHeeart LKairogeeyIntestine LiLuvneg r LNyassseharNyodBelan(dmsenteric) OParncyreas PiPatruaitthayrroyid SParloisvtaartyeBland Sul Intestine SpSpilneaelnCord TSetsotnisschEpididmis TTrhaycrhoid UrinaryBladder UJ terus LL Bone Clitoral lan LHaersdherNioadneGland LLyyaspshhNNooddee((tahbodroanciinca)l) Nesentary DoPseIGrCoTupENLasIe:IECIOENITIR0pIOIpLiiittiititt ital Waders R=RmRARRARnRnAnRRRARRRRRRRRRAR 355353535353535I5I5I5I5I5I55I5I5I5I5I5I5I5I5L5D5 A9S2S3S455S657S8e0b1e2e3b4s5k6s7a911T2717476777675 Ser KNRKRAKKKNNNNNNNRNRRRNNNE FFeererrebreerreraericcehsaieaaiiiiaiaieye SCiibbreserretecerrcearrsaairaieairiiaiehieieys SALE rer aaa FCeechreseserbeirbiiatirrrareeriaribaeirreeeyy Fbrhrcehertaebeetreaetaettactesrietrarrrieieieiry Fareetaeiaiisraery FFrieeireererbaeerebteetireai riarcricihiairteess aess Cierererereceesrieririny CSeieecrcicirecsricaeirecicceeasrrcccaerErearniecs LC icee rerer ract eccea sarr iicia riy CDiCeheeibi arriaaiicceresis e iarcaaanaeeys CCrirbebeeerrbearieeeitaeesestaesriirciaieirieieys FEeaerbeebebetiesbiaasbsircreerartriirriacieieess FPeerbeeerteeesastsaiteiriccaersiarrriiiicthieiyy eee A eee ee e Ce ee n nees a e ne ae e s B+indicates thadiaagaotsis was wate. A - indicates that mo diaguorocsomienat ws made. 385 Acindicatesonly a ondiagnostic coment wis sade, Please refer toTitshseueSianvgelnetoTarbyulPaatgeed: M22i1sal Report. Co773 [-- toes4 15 To YeiubeGU0rTaotaSa,caTr.nt30 Stay in ats . Sraatees:aabtr: ECRO2 Tissue be praia sas SSoittTiisess (Geee)n SSSiiitttTTTianosns t(ton1r)s) ists Tisee TRT oeRArsRpAENaAe:RECT RORLRR0RpRRAT RRARRRAR i ars 3353o333n333t333o33351a3a351535383I535E33I3338T35E353A398E3t SeRAd SN3REAiRsRa eArNaK0Ais RaRaAiRsRn eRrRiRnAeRe RiATNeRy enna CTSIIIIILTIIIIIIIIIIIIIIIIIIIIIIIIIIIN C CL I II T III 4 innlccaatteess shlayt Gpariiaas twadee, o-unmidcetesFatshet rneeagrrtsiohcsekSaeocteomreTnytlewasttedair2e.al Bet. 386 00774 . Tien tay contin ie Urine, tc, 1 oie E15 Te Yur Bk Teor epct Sty ts frsrectmihaeters ac SPT oe AboAT Roe,ROENRR0T pRn ERRARRn RRRRERRE TTL SC iiiiiiiiiiisi iiissiii4i4i4i ---- So FRiiEeETiPiHEsIaREaEnHaFnRHnEiRiEEiRnHRicEIoRoIHaIRsIYeTTs Sos nnn re nestioe Lr et atric) mnnnnnLLann ievenaanaen Peiwtboyit LSatsrsisisiseseeescseiiscsiriieseleieeess ipSotsytosl S n TI an T nL n n L a tations 40 saadas ta: ry tr Ln ee Th elmo Svat) wo ot Fee ERS) errs Ettraatn fstd S Le o ni n ooot Grtari) L La inn nn y ts Simi Cont i elo Tl 1T0sheSteonaehst05h0l775rt A + indicates that adiagnosis was sade. A -indicates that no diagnorocosmienst was made. 387 a tn cont ets eeiea i rio, Te te i it po Jegeot eers a2 re rit ns T0 tSo--n E1 STm frairTo oS n rgI pe 0T n n CnH HiasnnnH nnH nHhHy wR IRR ees o C C C oo mi n mn i CII gCaItacdiananatonaaiin: A+ indicatesthatadiagnosis was sade. a bs nofie rtettontm00i0n 7g7r6 8 A - indicatesthatnodiagnorocsomienst wis made. 38 - 5 Te oither tTioo,cco Tissue Inventory (continued) Stat nts [--, oJigchcitNemr: 2 tBsehroAoe CIL en Ran REREEERA aE a C S Lani n na ---- wo Sn Sot nn i tie nn seeye tric S de auapn agaaed eit AIA fTrereoeynn.s a [rr -- IS e Iiliiibtaaae r iaesinaatei iions: SSOpIeRedAsRaNanansnadss iy Bate PIII ee he elle i re ot en AR] Breenst imnst I 00200002I 4an00000I 00000000 Aer ene tGaennt sI IInI ilsI lsmS ann 1 + ees tat dats wt at, v-efiPocw rttiheosenTnitteea al 389 rt "Gory Tissue ventory (continued) Table: FC-143: Tao YeaRrikeOrralLaTboornactiotryi-eGsa,coTgoecn.ici3t0y Study in Rats SPpreocjieecst:NRuastber: 028100012 Tissue Nase prsekpinutial Bland SSoofftt TTiissssaueess hLebaddo]nen) SoSfotft TTiissssuueess ((leecgh)) TSohfytmsTsissars (hora) GUenniedreanltCifoimeednTtissue DoRVseREGRCroRDupLRIAWaEnAeI:RIRCEROIANITRERR0pIORpLRiRRRiRAtRARRE Boinal aber ===LLmmm neonones OG9re1Ib2Ib3Ib4Ib5Ib61a71b81e92b12E22s32E42E52s62E72b83E33b43b53b63b73E83D5 Sn FFFFFFFFFFFFFFFFFFFFFFFFE s se eh ee pn s een eee e ee e ne s een eenen i ee e ee e 390 AAc+iinnddiiccaatteessotnlyahadnioaangdinaotgsuiasstwiacs scaodmee.ntAw-aisndsiadcea,tesPlehaatsemr0efderitao gthenoSroicnsgolmeieTnsatbulwaatsedmadMer.inal Tissue lnventory Page: 26 Report. 00778 isan ovary (continued ibe Lsoratarios, Tc. 30 jr FT You BalTotrope Sat in ts Sreoleeshmstbrs EZ Tsun bie SRoT nRRrRoERaRtRRFT -E1R6R39R0ApRoART ARRRRERR tint ers ToIr33e3o333r3e3s3e3n33t3a3a3r3a3i5t3i3l5l3l3 S$E5R33E5E305T513T315059855040e040h0t0s0b0t0i1i1t P12E 3367T 01505H079I 0123T367E 8001 Torben enn Le tstioe rere n errr irr LTaenshytfel tester) Ln aapan nazANa IILL Fuses Civeviveterreartrtraint SSiuvlarysttoand Sim Gat C Ci aer vn arrrra rer rra errren rr ae, Tirnua, . TTeriedeidiamis Vivi rriverrnrern rrvarra rerire rir str nnnnnaanas eee he Fling Heats! we ot reed by rots eee Citra sunt SIITIIIIIIIIIIIIIIIINI Liehhtooid drrariea) Ds IIIIIIIp IIIIIIn IIIIIII 4 nscates hat iagis sas ane, - inicates ht no digs a coment ws wie 391 iste Testers ae:207 779 Ac indicatesonly a nondiagnostic consent was wade. Please refer to the Single Tabulated Anisal Report. . Tissue Invatory (continued) Table:+ FL-143: Too Riker Laboratories, Toc. 31 Year Oral Toicity-Gncogenicity Study in Rats Project Washer! OZBICRO12 Species: Rat TissueMane PSrkeipnutial Gland SoSfotit TTiissssuueess ((eaabdto)nen) SSoofftt TTiissssuueess(l(eecgk)) ThSyofmtuTsissues (Whorar) UnidentifiedTissue General Coment BosTeIGrLoLupENLasTe:IFIC-I14E5I30E0IIIIIiiiittt RARRARARARRARRRRRRRRRRRAR Arias]Naber 3<3o3s3s3e3s3e3s3s3e3s3s3s3s3n3s3o3o3o1n3n3o3o3n3s B5E5E5B5E5E595959595959595950606080606060606081616 Ser N1R2N3K5K6N7N0N1N3N4N5N6N7N9N0N1R23E5N6E7N8R9R0R1N s Ce a m e en n e ee ee e e ee e ne s b se e ee s n nnnns nnens eee Sees A+indicates tahdiaagnotsis was sade. A-indicatesthat modiagnasis or comet wis mide. 392 Ac indicates only a nondiagnostic consent was wade, Please refer toTitshseueSivneglnetoTraybulPaatgeed: 2dn2i8sal Report, 00780 . . . Tissue Inventory (continand) Table: 4 Riker Laboratories, Inc. 30 FL-143: To Year Oral Toicity-DncsSgteudvyiicniRtatys Project Masher: 2810012 Species: Rat TissueNase DoseGroup Nase: F-13300 pn RTIRLRIRARRTRTRIRERRIIRRIRRIRAi RRRiRRRtRE nina] Naber =m mmm mmm nnn nnnnnns 3333333333333333333333333 BTIEIbIE1b1b2b2E2b2E2b2E38383E383b38383b304b4b4b4b Ser N2N4K5N6N8N9N1N3N4N5N8N30R12R 345N679A014N5N forretnsal Bbornaeinarrow EEsroephages HKeiadnrety LargeIntestine LLiuvger Lyagh Node(aesesteric) KBausraayrySlut Pancreas Pi[ tuitary SaPlroisvtaartye Slang Seal] Intestine SlSpeinael Cord STteosutsicsh/Epididmais TThryarcahieda UUtreirnuasryBladder Beoeneeeeeeeeeeeeeees Tht HaCrldietorriaalnSGllaanngd LLyyssoghhNNooddee (abdoninal) Lyash Node(thoracic) Nesentary flloving F Sere b b rbae seb srey ee FF AREarbrrbar etaaeere LEFER PPaPa FC ARE ierr ssa a FLaebeieebree rrasaashi FC ARE b ier e rea ae S ee e ae n Farrrereraes ices C FAbeh rerC Cbesbi cc eraae sresE as ca ra CB erii a bbrsac sasbee aisac isiiae chris tyiy FFAeErEeer erers r a ee y Fibber ber aaaae rea CFeabbieeererbe ree se aaaaes FS EE b ee rib ete aaeea e r a Fabeiererasesieieieieiieieiny tissue(s) wS ere not requirede by protocol ---rg oereeeeeeeeeeeeeeene e ee ee e S ee e ee n Er Ee A+indicates tahdiaagnotsis was sabe. A - indicates that mo diagnorocsomienst ws made. 393 Ac indicates aly a nondiagnostic consent was sade. Please refer toTitshseueSiInngvleentToarbyPulaagtee:d n2i9val Report. 00781 Tissue Inventory (continued) Tate4: FL-143: Tuo RikerLaboratories, Inc. Year Oral Tosicity-Dacogenicity Study in fats Project Nasber: 02810R0012 Species: Rat Tissue ase Preputial land SSokfitnTissues abdones) Soft Soft Tissues ead) Tissues Ueg) SoSoffttTTiiasssauness ((Wnhecokr)an) UTnhiydausnstifiedTissoe General Coment DoP se GroupE Nase: FL C-L4S 30L 0 gpa ET rita] Mabars Rm RRRRRRRRm ARRARsRAsRnm RnRnAnRoRoRnRnRs 3B3i3bIbIbIbIbIoIbIeIbIbIsI6FsI8IbIbIbIbLbIbIbLbGb 12141504181921232425282930313233343536373940414445 Sex KKRNKNKNNRNNRRRRANNNRNKKN eens e ee ee e eee nee eee e Se e ee s e ee ee e gneen Crees 394 BA+ciinnddiiccaatteessotnhlayt aadnoindaiaggnnoswotaiscssciaodmsem.entAw-asinsdaidce.atesPltehaastenroefdeiragtuoostihse oSrincgloemeTnatbuwlastedmdfee.isal Report. Tissue ventory Page: 230 00782 Tissue Inventory (continued) Riker Laboratories, Inc. 3% FL-443: Too Year Oral Tonicity-Dacogenicity Study i fats SpPercoijeecst:NRaantber: 0281012 Table:+ Tissue ase faerretaal Bone Marron BErsaeiphnages Ere HeKiadrntey Lirge Intestine LiLuvseg r r Naasap ry Glan-- d ] Ptuarrcyreas PPiatruaitthayrryoid PSraolsitvaatrey Bland SwSapilnlal CInotreestine Spleen StTeosntsicshEpididais Thyroid UTrriancahresyBladder Boeecrsecieecs The HClairtdoerrailanGllaanndd LyLygeghhNNooddee Gabdoninal) HLeyseesnhtNaordye(thoracic) Beinal folloving DoTseIGLroCupEKIasIe:IFIC-I14I5 I30E0 IpoIn tiiiiiitt Haber -RRR= RmmRmRRmRmRmRRnRoRnoRRRRRRRRRERR A bibbbbbibbbbbL bbEBEbbEEbEL C1AIL4L5A6N7A8A9S0S1S35457585960616283658788707273 So FFFFFFFFFFFFFFFFFFFFFFFFF S Farc rrebreersesiiireeietreaeasaearreaairiesn LFierteteeerreeestiaesteesrieiaieiaiaiaieiiiieist SCeesrederrcceerrcceecrrccacrcrErcaarceEiiirieiyt iLeirieeeesrteetraissiiieiirirresarnearrraiiieesn LPeiebeeersceesrtciessiireariareaerrrirrriiireeys FFieterertriertasteatiiareirranciaiaiiiitss CEiRitttrercereesRaRriRrriiRiiYe VCeirceicrgecbcecrcaeieebreaoicaeiricearcacaaicecs CARR een CSeerbrca abcractreeaeaaercaacaaeiest Liiibrieisiireesrseteasririiriiiiirrraeieeanneesn e Cirrerriie aiaiereee reseains PLOiberceercesrcerRreReRsiRcRiTcS:e LC icteiricteistnrceaerscaiirrisrreernrnencnenens tissue(s) were not required by protocol =wwowsoweeromemcres J EEReeE e J eE e t es ee A+ Ac iinnddiiccaatteessot nlyaahdoinadgit naogsniosstwiacs scaobmem.entA-waisndaiudcea,tesPletshsaet rreofedr itoatgheonSriocnogslmemieTnsatbulwaatsedwadfen.inal 395 Report. Tissue Iaventory Page: 1 00783 Tissue Inventory (continand) Riker Laboratories, Tne. 30 Table4: FE-IA3: Too Year ral Toxicity-Dncogencity Study in Rats PSpreocjieecst:NRaastber: 028120012 Tissue Nase Prepitial Eland sSokfitnTissues Gbdonen) SSeofitt TTiissssuceess ((ohega)t) Soft Tissues(neck) TSoyftaTsissues (thoran) GeUnniedreanltCifoimedeTnitssue DoPseGrIoupONasLe:FCU-10I53I0L0IIIILIEI EnIy Anita] Mader =RR= Rm RRRRRe RARRARm RARAoRoAe oRAoRAS FbbEbEbbEbEbEbELELEEEELELbED AAAEAAISSSSSSSes68888TT Ses FLFIEAF5FEFTR8F9F0F1F3F4F7F8F9F0F1F2F3F5F7F8F0F2F3 aa b e ee e en e ee ee e meee ee a e e ee e ne s - 396 A+indicates Ac indicates otnlyahadnioaangdnioatsgniosstwiacs cwoamdem,entAw-aisndsiadcea.tesPtlhuastemroefedr itoatghenoSriocngoslmeieTnsatbulwaitsedaimdei.nal Report. Tissue lavetory Page: 252 00784 -- Riker Lira, Tn. 0 ie FE Te Tw Dl Torco cpt Sty i ats rjc huts ec Species: Rat Tie hae SRoT sARroREEtRsRRF1R0R5R0RT RARARERERRRS bint abs C Hoioo IIe IA Sm TEI ErR012I3a5RI EIERI01I3TEaE5T0IE E T0Ie01I 02I0308 ue iiiiiienttriiiariereenes Lhrrset tril l rrvivirirrii eaarreviess raed Siveeinivevenriveveiiies SSSaitiolrCHyossles GA s irimI iiia eeS erniL iin eiiE iees isons Jilin dttantnans ses roy tr ea ye es Th elon Hes) re Bt Foe A] rr Stl he Jaan LfUoesttteote brian)t L t L h n n n rics ol dri Const se Pae el iihesSoewtTo0Pea0ts:7w8l5ert, A + indicates that adiagnosis was sade. A-indicates that no diagnorocosmienst was made. 397 Tissue ventory (continued) Table4: FU-L43: Toe Riker Laboratories, Inc. 30 Year Oral Toxicity-Dacogencity Study in Rats Project Naaber: 0281CR012 Species: Rat TissueNase Preputial Blane SSceiittTTiissssauerss (Ghbadaotn)en) SSoofftt TTiissssuueess((nleecgk) SoftTissues (thorax) UTnhiydwesnstifiedTissue General Consent DosTeIGrLoIupTINasEe:IFIC-I14I3I30I0IpIpIIiIitaitt Arita]Naber +R+AR+eRRenRnRRnRRnRonRRnAeRnAReReRARRARE rrr 7G7E7b7b8b6b8b8b8b8b8b8b8b9o9b9s9s3E9s3s9T0T0T0T0T0 5789012345680134567801235 Sex FRRFRFFRRFFRFFFFFFFFFFFFF eee e ee e ne s eee eee eens e eb e ee n reese AAc+iinnddiiccaatteessotnlyahadnoianadginaotgsniosstwiacs acuodmem.entAxi-sinsaddiec.atesPletahaste 1re0feGr itoatghenoSrioncgsolmeieTnsatbulwastedmifea.isal Repor3t.98 Tissue Inventory Page: 234 CCOT86 B Tissee Inventory (continued) Table: 4 FE-143: Tuo Riker Laboratories, Tac. 3 Year Oral Toricity-Dacogenicity Study in Rats Project Masher: OZ81CROL2 Species: Rat - Tissue Nase faatrrtensal Bone Marron BErsaopihnagus En HKeiadrnety LiLavregreIntestine LLuysgshNode (nsenteric) HOavsasrayryBlane PPaanrcartehaysroid Pituitary PrSaolsitvaatryeSlang SpSiumaalll CInotredstine SStpoenecnh TTheysrtoiisdfEpididais UTrriancahreya Bladder Utmemrums Th Clitoral Gland HLyaarpdherNioatne land LLyyasgahhNNooddee((atbhdoornaicniacl)) Hesentary Boiaal folloving DoTseIGLroIupTNIasIe:IFICE-I31I0i4pi3piiiiitiiis Naber R= A=mRRm RKRm RRRm nRnRnRm nRnRoAm sRsRcRm eRoReRm aRnRnE 3bE3bIb3bIbIbIbbIbIbIbIbIobIbIbIbIsIbIbbIbIbIlGE AA7A8A9S0S1S2S3S4S5S6S7S8S9h0s1s2s3b4a5b6a7i8e5T0 See NANNNNRENNNNNNNNRRRNRNRRN e Cerbe eebn erais aarnis Fe e Faberchee rerteeere iniiiics e Febe ererieireabseaitsieerereieiiainieiness e Gen rbn er a a LEVira ey: e F ss E es Ce rcercherettte ereeiriiriey FCebceeirbearceetreeerteceoteacseiiscrrbriincies FCAeErbereasbteersacchaaeeaseaieriaiaiacsh e ee ee e SBeerrieerere eraserr iirrrra riiiis FFearbbeerriereesririesreresbeiscraasrarsiairiciht FFeebtbtreisbeeararseeeresiisiairiiicihcisy tissuels) we ere fot FAUIrede by protocol wewn eeverecreneeceee IIIs eae i be e e e ee n m SILL emes 399 AA+ciinnddiiccaatteessotnlyahandoianadgiaaotgsniosstwiacs scaodmem.entAw-asinsdaidcea.tesPtlheaaste nroefderitao tgheeoSroincsgolmeienTstabulwastedmidMen.isal Report. Tissue avntory Page: 235 CO787 Tissue Inventory (continued) Table: 4 FL-143: Too iter Laboratories, Inc. 30 Year Oral Tosicity-Gncoqenicity Study in Rats Project Nanber: 02810012 Species: Rat TissueNase PrSehpinutial Slant SoSfutitTTiissssuueess Gesaddo)nen) Seit Tissues eg) SoSfoftt TTiissssuueess(e(hcokr)as) TUhnyimduesntifiedTissue General Comment DoTseIGIroIupTMIavIe:IFC-145 3T0 poin nian RRRRARRRRARRRRRRARARRRRAR Anita] Mabars 31sTs3sIIe IITsIIseIeIss IsTnsIeoInIs oEnIne InGs BKAELbEESbSbSbSbSLSESbSESsSbebsEsEsbsbsbbbabnbiblE 785012345678901234567890 Sex KKKNKNNKENNNRNRRRRNNNNNNN Se ILI ne e ee ee e eee S ee e an s se etesssrse srsurmeen ressasas eee A+indicates tahdiaagnotsis was sade. A - indicatesthtnodiagoorcsonisenst wis wade. 400 Acindicatesonly anondiagnostic coment was wade, Please refer toTitshseueSivneglnetoTruybalPaatgeeds A2n3i6wal Report. CeTss Tissue ovestory continued) FC-143: Too Riker Laboratories, Toc. 3 Year Oral Toricity-Oncogenicity Study in Rats Project Naber: 028ER012 Species: Rat Table:4 TissueNase afaorretnaal Bone Marron Esaphages HEeert itney LiLaargre Intestine LLyuanpghMote (aesenteric) DHiaasrayarySlant PPaasrcartehaysroid PrPiotsutiattaery SSaullivaIrnyteBsltainnee Spiral Core SStloensch TTehsytriosi/dEpididnais UrTirniacrkys Bladder Uteras emma Th HCalridtuorrialanBllaanndd LLyysseghhNNooddee(abdominal) NLeysaesnhtbaordye thoracic) DoseGroup Nase: FC-3104p3a RTAIRLRLRERTAERIRIRIRERiRIRiRiRiRiRiAtRiRtRiRtEnRt Hoiaal Nagbers == mmmoooooeaseeeees 3333333IIIIIIII3IIIITIIL b7e1b7b7b7b7b7b7b7b0e8b8b8s8s8s8b8s8b8i9E5b9i9b9s5 Sex K12R34K5K67K8K90N1N23N4N56RN7N8NR9RN0K1NR2NE3N4RE5 e Ce rn es a eee g Cirberce eresiee siriarn iiiiie FC ebee reeer raser ssiaa niiir iee Ce irberb ee rrs e aares Ceres eee eee eePe RR R RRS CLoileiceeri cerase acasae ccceee rirt FCiabbibriearbeirbeieisaiisatcactearrrianrirnainyy e ee ee e LF eere eseer ratab sisie iiiir iey iCi ib iere etee eisb iiii iaie iiais aiian EDeerrreebterteisbtiasirtiebaiaetaieriaieareeeys folloving issue(s) were sot requbeyiperroeteocdol ----roe-eee-neeeeceeoeee e ee ee e eee eee ee es A+indicates tat a diagnoswias aade, A-indicates that no Glaorgconosenstwiis wasde. 401 Acindicatesonly nondagnostic comment was sade. Please refer to the Single Tabulated Tissue Tnvestory Page: niwal 257 Report. cCo7TEd I ---- Tae:4 R15 To YrHitBeaLTioroatotries,atnpe. c0 Stay i fats SPreeecsW:aatrs EICI2 Tee oe je SSiit TTiisss riyoe SoSSfiitttTTiTisisnusesss toeangrt))a) j Soe pfourt-- esT e Gow Me FH -1653300 E RRRRERRRARERRERRRARRARRRD 3i13L13E731i31e37h37i37t38a38i30e383b83i3t03i838i30e38i30t30i30i30t003s% P123P 1507eT n01234H587T80T1254% Cena FETIL m CLI m eee c III IT 8+ atctes that a Gages as ane, - nictes tht no diagnosis 5 comnts ade, 402 A c indicatesonly a nondiagnostic comment was made. Please refer toTothbeeSiIngvloe rTaybuluaetesd 28Animal Report. 00790 [p---- Tae4 43: Tee toirkae LTrotrriGscTo, 30 Stay in aa GJea---- oReTRrETwRRoAnRsRRF-A1R6E5R3R0RRRRRERRRRE PIL C1CiIA3L9A9990399739930000d7s ---- So eF4E7aE6uR0R0E21E2R23R32TE41ErR82IvT20E1I02R30I4E83r0I70T8T00S0 Ure nation os toe steric) sont Yanan SSSuilytatssie L r n a i n s en tea n n n Win Bate Transtar eee The fellnng Hana) we ok Ferd by ots meres ite ane anna CrrronnvHeeee Gincai) s L Sa amI t ee n Tot Tin 4B+iinricaite ihyt vdacpseonaes,t i- iandti.cateFltute rneeargn1.oistihvse SomictoomrTtrlawieesatM3,1il pt403 0791 [---- iter Laeatries, Te, ie4 F-13 Tee Ter BakTosra Scopeicty Sady in ats erstetna:ber coz Tose ae fr SSSohi TiToosnsues (Ghd0ee)hnn StTos (van) rnin Tose oReEI RroRREtRsRRET R1R5R0ARRRAn RRRRRRES C EE EEn EE E Sw CFTEeeFanTiiEiaEiFiHnsE1iF1TI1aT2Ev2Ia2It2T2sE1aR2Is2FE2En2rTe8mT Fp, C S Co I l h I m Colm cm 4 iInniiccaattss hnty ampnpnriiwcu uceom.et s=i insdibcatesFetssoreie p1 ste oSricgoemeTthaaratie l 404 fgert. Tse nets Ps 240 C0072 Tissue Tovey (continued) F145: Too Riker Laboratories, Inc. 38 Year ral Toricaty-Oncsgencity Study in Rats Project Naber: 028180012 Species: Rat Table: Tissue Nase areal fBoornetsNarrow Brain BEseeprases KHiedanrtey Large Intestine Litvunegr Lyosh Node aesenteric) tRaanrwyary Bland PFaarsactrhaysroid Ppirtousittaatery Salivary Gland SSpwianlall CInotredstine SSptloenenach ThTyerstoiisd/Epididais UTrrianchaersy ladder Utreerueseeeeeeees Th HCalridteorrialanSSllaanngg LLyyaspshhNNooddee abdoninal| NLeyseeonhtNaordye (thoracic) Brita] folloving DosTeGrIoupTNaseT: FIE-T31I04LgIo5aIIILIIIEEttIy Mader RARmRmAmRRmRmRmRRnRnnRRnRnnRRnRnRnRnRnRaRAeRie F 1777771771171a 1117177171771 S1I2T3I4I5I6I7I8T9A0M1M2M3M4B5M6A7U8L950T1T2I1S4T5 Sen FFFFFFFRFFRFFFFFFFFFFFFFE Ferbrereraeiereee e eee e n eeean e Fer iiibere rrcracere cearanae e Cereebabeeaerreeeesgaeenaeireeea Fe eeeeeretn eiieisarn ririnieineey FLerbeeeerreereerbaaisiastiirssrirre iiisey e Liberere ccesesn rsarirs riiies CFerbeeeerscetrrsiiceerrsriicahaiaiiiairteyy CLeeerbecreareecbeteireeerscriaastcihrcahiiriiiies e Cerbrerere ataritaee rrrerieieiayn H e en e ne n nes na Ser erceb eeei r a acey e Cee ib n a eeen FFrerreierscrheesreberccerseiraesrccaeicieiaiiiicc C Gibb e ba er sa s aaa tissuels) were net required by protocol ~---eweeeeeeeeenenee enen ee a een ee en eeea en m be e e e ee n 405 AAc+inidndiiccaatteess ot nlya3andoinadgt inaogsaiasstwiacs csoandsee,ntAwa-sianddiec.atePsletahste r7e0feGr ltoathge oSnricnooglmemieTnsatbulwaitsedmdAen.il Report. Tissue laventory Page: 241 00793 Tissue Lovestory (continued) Table: 4 FE-143: Tuo YReairkeOrralLabToorsaitcoiritays-,cogTaecn.ici3ty Study in Rats Project Masher: 081CROL2 Species: Rat Tissue Nase Freputial Gland sSokfitnTissues Gbdonen) Soft Tissues (heat) SoSofftt TTiissssuueess((neegc)k) Soft Tissues (hora) GUenneirdaalntiCfoinntednTtissue DosTe GIroupLNasIe: EFCL-31I04pIL3pELIIIiEiInnIy J RARRRRRRRRRARRRRRRRRRRRAE A 117171771a 171111111a 71177717 333333IIT44MM444444555555 1234567890125456789012345 Sen FEFFFFFFFFFFFFFFFFFFFFFFF FEene eee eee e ee en e eee s e ee em e s 406 AA+ciinndiiccaatteessotnlyahadnoianadginaotgsniosstwiacs csoadmee,ntAv-aisndsiadcea,tesPltehaastemroefderitao tghenoSroicngsolemieTsatbulwaatsedmadfei.nal Report. Tissue ventory Page: 242 C0794 APPENDIX ITEME STATISTICAL METHODS. 1. For memo dated February 11, 1985; see Tables 12-18 2. Foanrdme20mo dated September 24, 1985; see Tables 19 407 00795 : Internal Correspondence Appendix Item To Chuck F. Chesney = Riker Path and Tox = 270-35-05 From: Sally E. McCarville - Riker Res Data Ops - 270-3A-01 Swpct Statistical Analysis for FC-143 in Rats Oo February 11, 1985 3M cTraerbolnabFoCr-a1t4or3y ivnalruaetss hanadveobregeann waeniaglhytzedd,ataandforthetheressutlutdsy oafrefluorotporesaennatleydzeinthethedataattaacrheeddetsacbrliebse.d Tihnethsetatfiosltliocwailngmeptahroagdrsapuhsse.d Statistical Methods bThoedymewaenisghtandratsitoasn,darodrgdaenviwaeitgihotns toforbrapienrcweenitghotrgarnatiwoesi,ghtandto laboratory data were determined separately for each sex and dose group. Tofhesvearidaantcae.werIef athniaslyzteedstuwsaisngnoBtartsliegtnti'fsicatnetstatfora =hom0o.g00e1n,eittyhe dtahteacownetrreolfurgtrhoeurp uasnianlgyzeadtwbyo-tcaoimlpeadrinDgunneeatcth'strteeasttedagtrotuhpe ato= 0i.n0d5icastiegdnifbyicaanscteerilsekvsel.onThtehermeesaunltstabolfesD.unnIefttB'asrtlteetstt'shatveestbeen Dwausnnestitg'nsifitceastntwaast oper=fo0r.0m0e1d,'onthethedatraankwse.reThreasnekedresaundltsa htawvoe-tailed been indicated by the pound sign () on the mean tables. References AndeBrasrotnl,ettV'.Ls. Teasntd Mclean, R.A. (1974), Design of Experiments: A Realistic Approach, New'York: Marcel `Dekker, Inc., 16-22. WineDru,nnBe.tJt.'s(T1e97s1t), Statistical Principles in Experimental Design, New York, McGraw-Hill Book Company, 201-204. 408 COTI6 Appendix Trem 2 Psatgaetis2tical Analysis for FC-143 in Rats SeM:enr 02/11/85 CaonBorRviaerdrkg,eTWrB.aednt.ws,efeonramndaPtairIoannnanse,iriRc.L.ind(19N8o1n)p,ara"mReatnrkicTrSatnastfiosrtmiactsi:o,nsThase Anerican Statistician, Vol.35, No. 3, 124-129. kInfowy.ou have any questions regarding the analyses, please let me JSeimm sem Att. . c: Ler CathJy E.1bLiundsekmtann HEE/RNH 409 00797 - Internal Correspondence APPENDIX ITEM E % Le Jd. Sbinski - Riker Path aridTox = 270-35-05 fom Se E. McCarville - Riker Res Data Ops - 270-3A-01 weer Statistical Analysis of Microscopic Findings for FC-143 ove September 24, 1985 TThoeximceijtoyr-Omniccorgoesnciocpiitcy fStiunddyingosf oFfluotrheocaTwrobonYeFaCr-1Or4a3l in(DRiaetts) wteirone t`hsetatsiesxteiscawlelryeaannaalylzyezde.d Fsoerpaeraacthelyorguasnin/glesaiotnwo-ctlaaislseidficaFcoinsthreorl'ss. ExAancta=Tes0t.05comspiagrniinfgicaenacceh tlreveealtedwitghrouBponfteorrtohnei's oardgjauns/tmleenstionf/osrexmulctaitepgloeryc.ompIafritshoensexpwaescteudsedvalwuiethionf eeaacchh cteelslt wweess ugsreeda.terAnthaasnter20i,skthoennthYeatessu'macroyrretcatbeldesChiin-dSiqcuaatrees agrosuipg.nificant difference between the controls and the treated References Fisher's Exact Test: CNeownovYeorr,k,W.JoJh.n,'Wi(l1e9y71)a,ndPSroancsticIanlc.,Non1p6a2-r1a6m4e.tric Statistics, Yates' Corrected Chi-Square: FalnedisPso,rpoJrotsieopnhs,L.,fiew(19Y7o3r)k,, JSothantisWtiilceayl aMnedthSoodnss fIonrc.,Rat1e4s-15, 13-20. 47 att 5. EL MeCarville sgn cx MEE/RWH 410 00798 - APPENDIX ITEMF GROUP MEAN BODY WEIGHTS, INDIVIDUAL `BODY WEIGHTS AND FEED JAR WEIGHTS OF MALE RATS RECEIVING FLUOROCHEMICAL FC-143 IN DIET FOR THO YEARS NOTES: Code 1 indicates a control group rat weight Code 2 indicates a FC-143 - 300 ppm group rat weight Code 3 indicates a FC-143 - 30 ppm group rat weight - Codes 11, 12, 13 indicates the total feed jar weight for the previous rat AI weights are in grams _-- 411 00799 AppENDIX 1700 Two Year OroaflFu(oDireotc)arTbooxniciPtCy_14-3OnicnogReantiscity Study Group Mean Body Weights (3) + Standard Deviation Males Veseou.ay cHooanntroBl 1-W50 p0pm) Mea3n00Bpp2mWSD (0) ee3n0 BppWm sD (0) 2 716055.3%2 1106.45 ((6655)) 213642.3131 2111.70 ((6635) 71617..00%4 154.78 ((5300)) 5` 33394/07033 32180110 ((6655)) +27360.8736% 3361..68 ((6633)) 3+2386.95.3%4 3200.98 ((5500)) 105 44506122%3 4372073 ((6655)) 4+3330.1233 4394057 ((6633)) w4d4110..53%3 4347.02 ((3500)) 11"2 947350.253% 441374 ((6655)) 13928.08X% 4467.47 ((6635)) 44155..143% 4478.65 ((5500)) 118s S5I0521.39%% 4488179 ((6655)) 4a326s..04%: b47i.a5 ((6653)) 443887..59%% 5522..85 ((5300)) 222 552261.383% 5492015 ((6655)) 550.4% 53.0 (65) 3e6aT1.43% 4466..97 ((6640)) wase2: 45.4 (64) 551192..41%% 5534.76 ((5300)) 526.3% 56.7 (50) 2 30 556617.503% 5554030 ((6655)) 576133 567 (65) w7B5e093E S49144 ((6843)) sSime..9z%: e59n.s7 ((5500)) 497.23 51.8 (63) sse.6 4 61.3 (50) 32 850201.9633 65271.54 ((6655)) SS108537 5S22.55 ((6633)) Ss1e16.334 6632..33 ((5300)) 338 wo $59991.0433 5S5947 ((6644)) 684s 6116 (64) 5s2i0i823: 5S33.12 ((6633)) 535.2% 56.0 (63) 558745..04%3 6654.66 ((3500)) 592.3% 69.0 (43) "2 prs 661192..89%% 6621123 ((6604)) 625% 643 (64) 5*55040..89%% 5578..90 ((6633)) 552003 61.2 (63) 61000..45%% 6699..17 ((4493)) 612.1% 71.0 (49) s80 52 66296..213% 66730.04 ((6644)) 6863 11 (64) 55656..75% 6644..70 ((6633)) S0.1E 66.2 (63) 662118..19%% 7742..23 ((4499)) 630.6% 76.2 (49) EE -- 2+ SNuimgbneirfiocfanatndiimaflfserweencieghefdrom Control at the 5% level (Dunnett's t Test; a = 0.05) 412 00800 ApApPPEENNDDIIXX IItteeMmFo Two Year OroaflFl(uDoireto)caTrobxoinciFtCy-14-3OnicnogReantsicity Study Group Mean Body Weights (g) + Standard Deviation Males -_-- sWteuedky CMeoanntroBlW+- 0 ppm 5D (N) Mea3n00BppW+o 5D (N) 30 pm Mean BW4 5D (x) -_-- 5564 s8 665661..364% 7735..33 ((4498)) 668.0% 76.4 (48) 5+7873.156 7619..28 ((4488)) 587.93 73.9 (48) 664461..4+9% 7768..96 ((4499)) 652.7% 78.2 (49) 6620 64 667734..243% 7757..44 ((4488)) 664.5% 77.6 (47) 5+95093..82%3 7754..93 ((4488)) +5963. 80.8 (48) 665565..87%3 7892..15 ((4493)) 656.3% 84.7 (49) 6686 7 665506..836% 8728..19 ((4477)) 661.9% 84.7 (47) 650948..923% 8830..08 ((4488)) 608.23 79.9 (48) 666662..55%% 8842..00 ((4477)) 666.23 86.8 (45) 772 7 665680..38%% 8861..73 ((4467)) - 6*0610.81.%%5 7766..55 ((4466)) 667.7% 84.9 (46) 605.4% 76.6 (46) 665694..243% 8836..93 ((4455)) 663.8% 86.0 (45) 8708 82 667608..68%% 8853..28 ((4466)) 663.13 85.5 (46) 660141..683% 7767..75 ((4466)) 610.0% 77.1 (46) 666691..27%% 8889..03 ((4455)) 666.9% 87.0 (45) 8864 88 667658..61%% 8868..88 ((4452)) 678.9% 86.4 (41) 6v1671.7.5433 7798..18 ((4466)) 614.7% 83.0 (46) 666642..53%% 9925..67 ((4445)) 654.7 3102.3 (44) 9220 5 668960..00%% 9913..69 ((4401)) 678.3% 30.3 (40) 662210..86%% 8857..63 ((4455)) 627.63 80.8 (45) 6656322311..000394.55 (43) (43) 660.0% 86.1 (40) 96 10508 667757..75%% 9958..16 ((3388)) 671.1% sais (37) 662217..023% 8840..68 ((4455)) 625.5% 87.5 (44) 665539..47%% 8878..08 ((3389)) 660.0% 94.8 (38) 110042 66426.035%1.09193..25 ((3356)) 661239..34%% 8888..10 ((4444)) 665604..80%% 9953..02 (37) (36) _-- 2* NSuimgbneirfiocfanatnidmiaflfserewnecieghefdrom Control at the 53 level (Dunnett's t Test; a = 0.05) 413 C0E01 TU VERE ORALIDIET) TOX-ONC STULY OF FH-352E4F&wFCo-z3e4l2ieoInNi:RTS TVEACYHNIIAOCATIENSIT4IA1L7S6|1S 1H PsuechOFNUNREAETFS S [WA=L3EdSe. 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F1OPOeCIISRiEn o1i2i5 ebioiaipoliolbsss s1o0 313 1e6t5.5 FPOOIOSDEIDE 013335 ebzascSbelnolns:d sBno 133 1e 538 FioPuelIsdsedk 313535 ebzzssTcOoLlLoSnEe 7bao 312 e1o56.7 FFoepsetr 013555 peileoaneoiiiaress 4000 313 REISS GID Gieleiiss SUC 1a78.4 1528 FFOECILSiES 1O2L5S wwiionoeonaiioieas 4000 12 Foci ier Lo nostes a0 12 &1714 a RFOEOCLETSARS WLIEE awliwoleeoniietsde 4800 133 Sersis oli wioreried 30 3 1& 744 sas 1RAEIJSAE0 OLIDD oolleusseieiiteees2eo0 13 FOODIRR 135 031001000 G0 13 &1&56.2 PFeOiCnI B1355 buillilzboliisroze Soan 213 i& 725 RFoeciCse:R 613355 e0iiiliieoiileeces 1p0a 13 1@56.1 RFoEoIoSeEr 6115S5 ooiiiltseeiirasoie z0a0 13 RE3ES4 GIF 03iToilTs 0 3 a1617 17e. 8 F1OROEL3J5A5R5 103355 oGiIiisseeineister 6Sda 133 FOUOJRE 135 032001000 60 13 e17.5 seesimisis sw B 00807 THO VERR OFALLCTIEECTH)NICTIOAXN-ONICNISTTIUADLYS:SOFmHFN-352Ex4e.& FC6-218413cRRI0N12RATS TSEO:DAOYFSRADTAST'ESSMA4L/E281 FHEOINGHTNUONFBERFULLD-F3O4D0D JAR:S S60GRANS EEK 1 F1OROeD3JsAiRc 1e1i5s oeiiseeie0e0z313ss 970a 111 1ReISIT 61S oieze0zis su 1 32183.7 5 216 6 F1ROEO3D5JIASR G11155 o01l0e4Z0o0e2s1e1s 1100 111 FOODJAR 11 0i0S0e34s 40 11 324151.11 345.4 1FOROED3JIASR 1B1I5S oO1l0o7c0e0n3z2I4d. 6600 111 1RE3520 01S 010300220 60 1 232344.s6 220 6 F1OROO3DSJ2A1R 0111S5 001110030000230345 6900 111 FODOJAE 115 011100354 70 11 233054.56 354.7 RFOoOzDsJaA:R 1e1i5s 0e1111320000231431 8000 111 Ress eis 011da0214 SO 1 2E211n5485 F1ROeO3DsJ2A4R 1611S5 0e1i1i5S0a0o1z9s9s 2602 411 31935026 FooD35I2A5R 1011S5 0o1iiizvcedeizeeds 870a 111 326046.7 F1ROeO2D5J2A5R 011155 00112105000623057.5 4800 111 FOODIE 115 012100341 00 11 230575..48 a1 F1OROeO3J5A2F7 611155 001122230060231454 1500 111 G2a15s1s 1FROeO3DsJzAeR 1Re3s29 1B1155 015 epiizzdSveamzszzsc 01z8e0213 4100 10 111 1 23256.14 213.1 FRo5OD3JA0R 1e1i5s e0i1z278e0G0i2z3s0 0800 111 32330:6 F1OROED3J5A3R1 10115S 0G11239G0000324141. 940G 111 FOODJAR 115 013100348 20 11 321414.49 340 2 F1OROODIJSAIR2 011155 001133320000324125 2700 111 32412572 F1ROeO2D5J2A3R e1115S 001133450000233245 6400 111 1Re3534 81S 013600215 50 1 232354.64 2155 FROEOSDJIASR 10115S 001133780000314545. 3300 111 314538..35 F1OROOD3J5A3R6 101155 001134900000316597.N4E0Q FOODJAR 115 014100362 10 11 1 11 315675.4 62.1 1RCOO3D5J3A7R 0111S5 001144320000324226. 2500 23538 01S 014400220 50 111 1 32246252 2205 F1RoEo3JSA3kS 10115S e01144550000324100 4000 FOODJAR 115 014700355 50 111 11 321400.4 3553 . F1OROED3J5A4R6 01115S 001144050000230532 2700 1RO3S41 015 015000227. 30 111 1 2s0z371 227.3 00808 pene a -5OPY AVAILABLE x mons Ei CRN EnSEE | ue: LaAN , =iz:e E R R aS mm T E aa . s 1 1L 2I3i mze3e Done ms semeemrns 1L 5mw7: E A S h TN eRae a T m Lhk 2=2 zmete BEST COPY AVAILABLE = . n ELaE Es N : L B=i.s CO! os0d TENehEREE = p sSb hena Edb Eis RnETEE fI =55wes:]: PfGEeEEebSEaEeR Tlr:1 2o=He Hem anamsin 2 2 TSEpAianoNnmnHlEIiIaEnNmeImEEaERssg L ==E#Ei.i JEEEEAETIaEEEE I z2, EDDeuenmmimmmaSi msmmmnaaEn SEEamnE | ##EwB2:1iir 2: DSEeErmmHnaainmseE i53B32 BEST COPYAVAILABLE TEaEim miaanniE | &Bi . SmGEoTIoERnE Io :a 000819 FiFooFboeup3IadRnoeke 1c1o52c%5 o0e11i444s5s000000i12e95s95 0G3000 21122 f3a5rs5 e - FiORaOtDcIaAsR iRo3ii0 a2c%c oct 0011447g0000i3s%eS. olasooaze 3500 50 212 2 f3e5d5:5 226 5 FFROODGDLiIIrRRaEE 01A22c:5 01011s55z01e00d003r251i0034d00a 2212 3Z5i0a1: Sid FiORNoGsIiaze iFeniis o1c2c: oct oOoiiisoossieeo0e0izszesee.e7bd0a 2122 - 23Z05a6 r FRooozoeiinae caaz;soiscoacsc0s 30 23 2S8o0u3 iFFRooeousosibinese 11c22o55s ppoiiis1s75ceoee0or0is3se4d.s 7oao@ 11222 13447 368 iFRooO3OiIiRcR iReaeir c1o2s5 cos olicciooooenieszy oiczooiss 034000 2422 i3pr6i23 FFiooRouebo3ii6mnikk0 401222%53 0coiiicccsasoaoe0as1ressese 13560a 2iz 12 3i654531 35 FioFoobaieniks iRoezn 1o2o5f ozs oOilccorooeaiszrre oicsoeed 15S60 03222 ie377a76s1s FiRO0n3o6i3n1k FOODIRR 01255 155 o0i1c7s0o0o0s6s3y 017100a00 841000 a222 03ie50r7.a38 iFOR"Oe9Ds3Ie6Al2k7z 016a22s55 o0ii7r74z30o000o23r0ee0s 36700a 2122 13206605376 iFOJRUGOoiIzAaeR 641222%55 0eo11i77r67s0oo0eo1s7sr4s.se s8do0a 2iz 12 3a56es ze iFiFOoO6aD3eI6zR2sR6 1c62o55c% 01oii77ceoeo0coeei3zt7sssS 84s08b 1222 Laemsae Zee FRFoOetOsbDeiiaaArkk 10122255s cooiiisceiszooeeaeszsresdis 17saa0 12a22 S23a575t iFioRRoeob3sj62a2sR5 a012z2Ss5 oooi1is0escdo0oo0eza1ee5sz3 710a00 2122 Z3io6o125 7 FiFORoOaoDzDJeIAiAReR 101222555 10bic1c00v00e00oe1s07e78s 325000 a3222 3oirr6s :25 : iF1ORROeoD3eI6lA3sR2 o1022o55s 10ei10v51c20e00e03z14t5s57 562000 222. 32i41r55e5 FiFROO0OO3DD6II3AA3RR 611222555 1015105534000000332760310 86900 2a2 a2 23060S8 ime FiioRRoGoo33u6en33kss 16a22z5ss o1Oii0oo6vw0eo0ae1zs5sss8s 7s10a0 i22z 3iiee2d?2.5iy7 COPY AVAILABLE FFOo"Ou3Dp6Ti3Aa6Re 1012225%5 ooosiz0oossaceoee03siocsssr 7S3aaa 12i2z i335675733 iFiORrOGoD3aJEtA3oRr 04c22o5ss 6bbz0o02ss0oe0e01i39cs5es 523000 212 3fie55e52s5 - FFiOoROoeD03Ji5Aa3Rm9 o11o22t55 O0cz2a00ocr50o00e0ir3cc5ee8 77s06a 12 iz 313065006772 .00811 FPoaousieae u12z5 0ozz0essceeoiissee 8100 122 956.61 8 FRoeo3O6JaR1E 012255 GGr2110100e0z3e6r5 3800 2iz Ro3gez 025 021200174 80 2 2r306a15s38 iFRo"eoG3ooeaiaansk 161222555 o0oso2ii1ss9eo0ee0ss1ts0rs a82000 21a22 6337087.3.824 F_osontcoasde 102255 oozr1i7ceose7ias 2206 12. 2.- 5ie7s412 FiPooosbegaes 1o2c5t Gcaaiizzeeeeilcszr 4200 212 3i662742 FiOROoDTISAeRc 103335 b022z210000031853 3460 133 385.343 FiorOeLiIsAaRr 133c5 o0222s2c0e0a2z3e8 71a0 433 3263.781 FiorooolJcaeRs 10335 o62a0z4s0e0e2a2z6e 3200 132 $22266.32 FioRoeo3sendks 013355 oca2zeveoee2a1s3e 12a0 133 F2r32 FiOROeDaJAsRo o13355 0oc2s2e0e8o3z4i5d. 1500 133 3e69s1 FiROeOsUeTsAtR 013355 oo23siecceesze0ds 7000 133 e20a8.7 Fioroaosleesrz 10335: o02z3i2z0000232465 64a0 133 32445 4 FioRoGoessa:k 1a33% o6z233S4o0o2a2i1s e6a0 133 T22e1e6 F1o0o3o6J5A4R 103355 cB2e3s0r0e0e2s2e2a 3400 133 322420.54. FiorogoiIeAsRs 1a335 0e2z3s9s6e0e3z3z4n 4900 313 23254145 3RoCzolSReE 1032:5 o0z240t0e0e2s1z5e s7a0 33 3225075 F1orOe03T6A5R7 0133%5 0022447200003241065100 133 3219015 F1o0o3s6e5 163355 G022444%0o6z2e1a0 05a0 133 3241005 FioRoGosJeaSes 10355 co2a4ac70e0ozzire 09a0 133 3207s FioRoGosJcaee 10335% oozzeivco0ezr0s7z. 2200 133 2207..2 2 F1OROeD3J6AER1 613355 602255100000324235 6700 133 32453.76 FioRoeo3JsAckz 163355 o022552r0000230%3y 0600 133 32507388 FioroeosjeneRs 613355 o0223o4s0e0s2z333 8300 133 32233383 F1ROeO3D6J6A4R 103355 062255670000231357 62a0 133 52179.62 F1OROoD3J6A6RT 163355 602253900000323370. 4600 133 323370.64 F1oROeD3JsAeRe 163355 c0226e010000234233. 5700 133 2203337 F1oroeb3j6A6R7 163355 0e2266270000230%6. 67a0 133 323066..67 FarOeDsJsAsRs 162355 0o226c5a0000316%1 45a0 133 319681.54 BEST COPY | Je03J6aees a1i3s5 aoz2ccereoo0zsisze e7a 31,3 23132.7 LE FiOROe0sJeArRe 10335c Dozecwoeceozrzirz 62d6 423 32323710 - FiOrOoD3JeArRy 132c5 0o2z771a0c0e3r4z5i 0500 133 3242515 F1oRo0o3J6A7k2 613355 e02v7i2e0e0s2z31e 38a0 43)3 32216.63 424 coost? rsTeoeeRrls eoEisgSoarwEtozeTe sBei 3. PEr BSoIi T 3D:EdCsoesaeirss-- SaE b3b rTH hoesoimE s LGEF Theat 3% SSnGeeeeeeeessna8a8 3B5bbb i oeet RoE EFiifrabGSiieiemeaeerksnteak 8B3b ieFTroaoiiestes b8SE3ef: EsSSieseeResinsieEoaa b4Bb 3 oMoTeetta DE EE IeamEemmNeea BO8bSb HoTeosaem ONES ub3%tIssaeemeemsare BE Soteere a 8bBbb 3 PeFoootrs i: Ug3tES af ScReosNonsEleeNssemtt En abb33 LFRoTosolioo: bgL63tEf% GSeeseeeeeennnnysaslem Db33bb oHCThineooee:: 8a3D%:iScSnieNoeeeennaaab53 FDFoeoosmoe Tena 2a0D3f%rGiGoisdRieeeassiene tissee bb33 iRTSoeEoweRrtIEB4O3ff: iiSidsOveESeereess s skn b b3 mnBeeHta osm=ma3iz 33 23s3 Emn1tit 5sFi3e nnHeee 2EEA,e F2 5=s:H 52253. u5He5sd3i 3 B3h3 5i n58es. EEBeHHs BEST COPY AVAILABLE 00813 TH VER GRALDIET) TOX-ONC STUDY Tecan MITIRLS OF FH-392e4t& FGE-e343isIN:RATS FEToonmSeTsunRBDEARESbR-SESrse0/e0-330 Jr fs vex 2 iFsRomeoosbsaisimsrec o10i11sss cceaoorrrsizoeoeoeszsresas ac0a0 +11x =S20i0 e FiFfooecshcesiiec o11i11s53 oboCarorcrsotosoosrneeerrs odaoo 11 dx rBSees iFGRRooeostiescieet 4o11i1%5l SoooCrrcocoeocassss ddvaae 11 22Ed,H FiFRooeoosissceey 1o11i15:3 ocoiiiooozwsooevrsessases sdaaa 1+1 5=525e5s GFLRrooeo3tsieec o01i11l%2 ool"tlooosstooosooesrrsesan scdbab 1a11 BSweess aiFobPolaosesessw 1o11i13s5 Soolllooocrsaoocosszsoseset aa40 1a11s Z5as:7 FrFootonGoo2iss5nee2ws5g110r111e253 goooriiiioiesssooersocesrssserses s5e8 sa i1t it = =EY EH GFioRRoGeoSisCleGrw 41o11iS%l iiitiievsdoeecssrreresee d2zaan 1i1t Ep=Hh FfFOoruooesseies 151111%%5 oSoriliiigstoaoeszssaiicsr sssaaa 11i1t EEZrre iFiRRoGooa3isiaey0 o10i11s35 oeoiiiiztviaeoeooszsssesee e73oaa 1111 EE55YH7 Fi"rooeoossbseii 1o1i11s53 SoGiiiszzzeoooooecsmrssesr sasaaa 11 1 ES5Ah6ss . iFipGRaoesbsssnesem 014111535 ioiicscssvoooooosciosseae acaa 1ir E0ZHcs FiFoRoGo0o3oJssaanRss 611111555 oeiiigssoveoaocorsreeerss sa4aa i1itr HsEsse FiioRRoeGb33is3n55e76 0w0i11s55 oioiindsssosocooscrasseea dsaaa 1111 2= 6s3 F1oxGo@os3oe3n isesins 1G11i15s5 Gil oooiiisdzseeeocoeescsseezs Sisvooear so4aa8 3a di ix 52S52e*ad BEST COPY AVAILABLE rs - FiFoRooGoo3oi2in0ae6s 15111155 eoiiiszsevccooeoosrsiessse gzaao i111 tng ep pit 3 s2eascs = 426 00814 eFFoocueosens 1a511l55 ce oilszeon sisics E 3sa 8dh11 RFMoeetoens 33H11%%IichvEeeaRst 64E0 h31t FrooGiot2eoe 1111125% Gbiiitaetoeeessreseee Ss2aa4 1i4ss eFLPouiaae: i0d %t beiitia ieeeensessr sEdea LL 1 HLFRooOoSrSsieec 61111%5% ieGdciotodececsessseesrd e50a0 4hdaa FeCHirileoassismieeI: sa4iiaSc: ilmsiecsaereecssiencersse eG cao f3be sa is FiLPleeonepecs:s a1Gii%fs iGsiclctfieiescetaeirsce dosaaa 41he oFTorose ee 1Ga 1i3s eos iicciioe esssiec @aa@ dd1tu fFGRReaoiecnoss Gaaiiis:f eiCicceiveeeeeirsesis tszaaa h44a FLFhooeoossssieec a1ii%cf eoeiiirreisseeeiscoeessi ss3aea &iAtt e o3v5e% isitc e firlseestes 8taa h1t FFmoiooceirnek 5a1115%iooeiiTrrecEseeesniessIs n81a hidfut FSikniaoossssrice:e ie1i4cs% Seliistriessseeessisesrses 17raaa 441a FG Folcooosrne ss 3311%%l oeiicssi eessieiee 1a a oiiftt FiifRiueoiieocciss 801113:% ocviiicccssraeecssriseserss fesaaa 14da FFioRooooonieselent 011111%3% sCsiiisctesesseeirssessee a4s8a 4ad1u CFIhRoeosSossecrrs 3o311i33s oeeiiiscstaiecceeisrsseees a7saa 14de FFSooRooeoossscoeswm 13111133% eeoiiisssssseeaeeessssesrre aasa ii1tt iFfoooassces 3311%3 lisoereesstadr afa d4e F1aw8oSe3oio5aso7rem0i 84011111:%53 0sSb1ilr9oeo9sst0eee0eee2nsi6is6srs.e o77raa0a a1h4a iFioRRosebsiiinsck 3ii1ss2 bbliioooiiosceeesseesss s3sa0a 43i FDooeormne 3a13rseEcRs Jna fde Fosress fe3eit EE2rd: EFFiiH ia 21 BEfeeSee pH2ee. n3 Seet EEESHY 23E+3s 5B=3a $=mei ifsee:li E2EEv; HFSeeeil 5misee 5Er33 F3 EHH $2e3li $2#E65e61.77 BEST COPY AVAILABLE HF2rl: 2 FE 00815 RFOEOSLITASR 6111:5 0LzoosSoeeO2IsL3S 3200 111 2365513 iFOrCeDsJSA7Rs e1i1s5 0r2i1z0o0e0a3s3s9 4400 111 2363s544 RFOEOIDSITATR 6111S5 00z2i1l2d0e0z3e4s0 B0a0 111 s348e FOO2D5J7F8R 6111S5 o0z2i1s4e00023e3l0 S60 0111 233166 FrUeOiDJsRsR e1l1fS o0zZiizceeaez3sSs6 8100 111 2355s018 iFROoOcLsJcAeP o1l1f5 0cziivgeeeezseeld 3100 111 23641331 1FROOO3DTI5A1R 6121%5 0o270a0000523458 0700 211 233158.7 F1ROeO3DSI5E2 012255 e0e7v320008234433 6100 212 2S4a531 F1O0O3D5I5A3R 612235 bbe07/e0000138397 320a 122 138397..32 1FRoeo50sJsAsR 612255 bbea7r7ee0032e3s3 4e0o 212 233536.4 1FrOeo3DsJeAsR e1z2s5 vbeer7sB0000233S6e 070 212 235306.7 RFOeOsDIsAeR 612255 001100160000235227 2600 212 232572.26 F1OROeDIJ5ASR7 012255 0e1i0e3z0e0e23829i. 6500 212 230291.56 1FOROeD3JTAsRe 612255 001100450000327306.3100 212 237306.15 1FROEOIO3J6A5R 012255 0011007600002325437300 212 232543.37. ERFOAeOCsD0JJsAAeRR 611222555 061100980000237342 2400 01100031530 122 12 233724.24 319.3 FOO2D5I2E1 102255 011112100003251132100 122 32511312 F1OROeDIITA5R2 162255 6B11115400002344202700 212 234420.17 1FFOeO3DSJSA3R 612255 061111560000233456 8700 122 C23398.7 F1ROeO3D5I3E4 122%5 601111780000235118 7800 122 i318e7 F1OrOeD3JSAsRS 812255 601112900000233372 6600 122 235372.66 F1OrOkDeI3AsRs 162255 00112220000232342 7600 122 235224..67 F1O3O3DJ5A7R 012255 001122346000234349.9400 122 324349..49 F1OrORDeIsAsRs 162255 001122560000237243 3300 122 327245..35 F1OROeD3J5A9R9 012255 0011227000002333571600 122 323375..16 F1OROeD3J6A6R0 162255 001132090000324210 8500 122 32421685 F1ROeO3DeIeA1R 102255 01133120000235246 87a0 122 325248.87 F1OrOeDzJeAeRz 16225s 01133430000325250 3700 122 23525.73 1RE3663 625 13500249 40 2 249.4 FeO3'O0cDDJeJAAsRR 1012225%5 b0111333976006000233254104.363a00 12122 e23504s.13 AT 0oPY AVAILABLE F1OrOeD3JeAeRs 16225s 001134900000234472. 7200 122 234472.72 . F1OFDeDeJ0AsR 612255 6114412000023264.1 70 122 1Re3er 62s 14300261 40 2 23264137 2611 00816 . FiFoRooiouiIdtnoeks 1o122lssf oGilisevssseeenecssczsesss d72aa 12 az = 2md2 LFioRcoNosoiGmoes 31855%% coaimsveeieoszriiet 2seaea i32z BEiwede LFooGObiiien i8a5zf%: eoiiistisemervisiseczsesa4e00 a2122 Es= ei) l rtd A ES RFooeordee o12i5 measeiceezia s se faz E530X.1 FFIoRooeopaiisinesk 1512522%5 oelirssTeeaeoceeisnseairs 3s0aa 13122 = a22e53 fFERoEoosoaesietcs io1z2Es5 ia ociisoeeossm daes saab212 E5#n73 FfFRaoen3cioiis: 1b15i2:s pooiiicscsszoooooeessesasss as3a 12122 f=5ae5:3 iFGoRRoeGbciieinssk oo1i2i:5 obmiiicstreoooossmsieisss 3 efab :122 Z=pere2 FiFoRoooob3oiisaiek0e 1o12s25s: oeaiicrcseeeooneaisssss 0ss0oe 32122 EEFrSYo] Dell EAN R f 200s F"ToUoobisse:ew 4o1k25t5 oorrivvrizssoeemesasscizzs as7ea a3122 3H2e2277 iF1RRoaeiscSechsyet o1oi3s:%s oooiiivrrsoso0avrnaisisnr dv0ae0 2d2z H2El7Y FELoalotooeisnitn 1o1z2a: oosiaisrtaseoooecsazatessre d3so0a i2az2 enErdd EiiRPGoaossoaiiadkre o1oszass ecoaiieoiatooeooccsseeasls ss0eaa 3122 ZS=eids FiFRooo3ooa%nks 1o12z25s cooirieascseeoosonssetesss da7aa 12122 5HS5ee7ed FiiORROoa0asoeemnaRos o1oz2zs5s oolaisseaevcoeersoitsrsses2raaa 122 a5Eres FiFoRooob3oscenrw: 1o1z22s oooiiisssiezcsoecnzseeetss dd3aa0 a2i2z 2aisel iFiRRoooos3e6snaesn c1oo5zs%s ooiiisssssooeeoesrsseesss das0a 2122 2555883s FFioRooa0ocioeanaRss o12a25:3 oooaiisssrccoooeeoisszsrrse aa7aa 12122 s327s71? riroe0ds3be6st3ac5 oo1zs3s5s biisoeowei.ccoois1ss0es7.53300a 2122 22H2sN3 BESTCOPY AVAILABLE FSFoRouaoosbiiiesnwrk o41s32s5% bbssseoossieceaeossstssss ea2aa a2122 B2s5er? 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C00827 iFsopFOeoissitenosks oseiiasSs oaezrvoossTeeeucnissietiss sizuee 11di EEasSes FFiRGooooscisrnee toaiiisss eaoxzscieezssotsciedess 36r0v 1a11 EsBeesey . f1pe0oi csnarre Geeiifss eSeassihseeoediiieaet aSwvn 04b1s BHsEes:ss Foca Eochow 11s 115 SE eomgcoeeessseeY 4Tu n1a MsHreai: LEiRROeStoSaCc:e 1o111s55 eoorariziseeessseseaesis 14700a 121 CeeEol7 FLFGRoooobsb3eaecre: 1812525%5 0SGorolrdiseee0ssiisTaesrs 1rs6a a:3122 e=3l7: fFirRooooisisssecsea o1oz2zsss ooeoocrorsrseeoevocisireis re3ud0 222 = Sa5i6 s FfFRooooostieiocens 1o125o5: soseoirrciseooesecsrierree sicaa 2 12 Srseeeees. iFfFoooosiasceer 61o52z5:: esoliiooozswoeevcicasssees 1f0o 0:iz HS25e56i53 FFJ ooosgcoseers 1i2s3 loleocseoecsirrr sfaa 2 iz rrEeeE iFioRRteeosrsccehsr oo2ii5cs eoirloocvsaaavsoszsaessss s33aaa 22a2 S23a8a383 FJFootoibesieaek ao: 1:5 r eoiiizsee saiiis sa en iz iz FHSreeeests fFipeoasosetssse: 6aei5zs%: Geouliiissseaasnsisceetir sf6o a:2iz HEeoEd FGFRooeoltoisiceehe iGiiEzsE: eeoluiiizvsaeesssssseeeers fs2o0 o:a422 35508:2 LPiRriaecszeahioitn 31o22s2s eeoiirtievseeeneosrieaeres ds6a u:i2x 2S=65s1 FiFoofooeibeiileenkw 46i25is%s GSeiiitcssseeeeeesrsersrsi 3a 500 :i1c2 E=a:3 iFifoRaoesoseiionose 31o52z3ss ooeiiicrcsesmseoeriscosse 0 soan :iz = B=s FFiSoRooabo3ioennce 11o22z55s eGiirscsevsoeaeossrseessr otada i= 32 =3pi5s iFiRooooeoeoi:n oaoz2zs:s sGoiiiissszseoeceorarsseree t32t6a 32 e33056d2 7FFoh5co6boii5nR5:e 1Gi2a25ss coeuiislsoseeesectsseeerss rssova i2izz sH5iz3d"BEST COPY AVAILABLE iFiRoPcGasicisonsss o1oo2z::s eeoiiissvsaeesscsrcseecec e72ad 4:12 eSZeec?2 - HFiRoooo3ssnees S1o2zR3s aeoiisalesesasescserrs m44ed 0:B1e2 3sfr7el 440 00828 TTsoiiisRoiieE33 aoemlennksy66 kofe H5sre. RMoLEsEmS diEmaeAann EnE yEeffn& =E2HeHse ; oPJ wimie AiE uaciNmseeennnkkF3 O. Su5 Frieo. REEDeneNsnmEmssauaannmmeeeieEmnnEelff6kL FE=8er, a NSEk tGueunnnmaecnnhea f mFiee pi HReektdia EiE ecGN epnnea E a b wk o=ee3i EMEREAEEELEEdEEaAAGeNESkSeaNEEEin k3bfFb 2Fi mH:E FTmDoEeEiSmeSEoEFaaeanmmenaEnnnieniR iLf=b s=585idi3 rRTTaENetmtEE Seaa enNn nn RyffCk mi2 5Si EstTemeimmEaanI nneNEanlnsk6ob nEEoiHei. RfFfeaoaSilsre i= i Maaseenmnnn 2fF e25Bsl52 Rt HeSeoiE5IgDaGae EnomNnrEEeInEanfiOk Su1aes1 RRTReunSEee EEiaaaannmeneeinnnniegEt fkbfFLk 3@EE5o2E1 EeFeoeRottGn aLit auasimmsdsEioennnli10 2L1fF2 smi31i:i . GHuem FS S8aaaelsrneaeenernie n ts kfnFfe 2Ee1il EH i eFCourimme fi S5f3 G cEaolNoa nniNse f nwEffn3 E1 H=eH. BESTE0PY AVAILABLE - TDFoREeSSs 13 gGclemseeEenmdne nse fi2e EEaHi 00829 DGEehellUoaEF eeGaennelEE n x fi5 JHFooissieee a1m5:er sncinte eenine ifu a Lk CwSlEi ESiEi d NGiEeSsIe N 2 F1fF2 M HHeuisnee e OFaEChRnn eNeEd E0Efnihe el Glan 3 HiHPooehseee: G3U%5iSeeiitesmeeeninnsiiae 3 HoINeiGiEeStT 03e3%% eGeisesne esss vseaa B13 LDHeieitcmesa0Gt3ietratsear 30 33 Hoe CIEERSRE kb H[FSooertie GoiffiSedvveeeornn ae a b313 HDDoeetmre igfsaeenmmeaewnsnnsne f1fF Hote if edesie bs 3miee 5H=se EiEidi: B5 Bdle es #EH1ie X33e: 3EEm3ei Ei 3 Hiei iEwENe Ei HTohteee ELEf eahkeeeise i3 EESH Fooii i: eames ra 1 3 HHDooevine Udifreeaseemnetay a B3b EEEHeH Foose 13% eisseist sa 13 Ses FCHRooeosstiees 38o3%f% eeesroomereeeeiniesr 21aa0 B3s EEEvHi PFTRoeeoisice: 83433%%% Sosiiicscssteeeeeerrrssese avsnaa 3135 5E=1S HHionotceee SD63i3ieesdeesheesineeriah 3a b3 si Edi TDeOteSeeB0rlS etgeateeesnnra 33 H52e7sd DFoceormne gLitieaimnani a4 3 m3e - FiFR oROoaOosUoeJrrAg daR e11s3s5 er c2o7r0pi0c6ee3R s1es7s.3rsGaa 3113 3 EB317Iy.3BEST cop AVAILABLE semotEMRE LL HE 442 00830 F1O0O3D6J7A3R 103355 o0z2775e0o0e3s1e7d. 6e0a 313. 3w6r4 e F1OPOeD3IEATRe 103355 GGiir7o7oee0sIsLzY 6e0r 133 33128 8 FROeO3C6I7A5R 103355 b022o7o5a0c0a3z5e1 S6o0 13.3 . 3B24es |1"RSeaJ33oE6i77A?6k 8B133355 GeG2zzeEstszeecceeiistizar Fe1ao0 1333 3337264761 1FrOeOsDeJvAeR 613355 o022e6s4e0003343z5 6100 313 3343251 1FrOeO3DsJ7AsR e123s5 e`z2e8r6e0e033z3e5 s2a0 313 3s3e8.52 1FOeO3DcJcAeR e133%5 6e2z885e6c0e3i4d0e 600 313 334400 8 1FROeO3D6JeA1R 813355 b022s516000033e2T3 6700 313 334232.7 RFOeCsDsJeA:R e133s5 ee2zsssze6e0niizc 4700 313 331:0647 aFROeOsDeJSAsR 013355 06228945000023742 020 313 334762.25 1FROOOzD6J6A4R 013355 00229967000G7I440Z. 7600 313 3314827 1FpOeO3LEJeAsR o1i3s5 b0z295s8e0e0i3i3s2 1600 313 33125.61 F1OROeD3JEAERE O13355 Ge3ieeeleeeesisiti 6s0u 313 3s1e1e6 1FrOeOsDeJsAyR e132s5 eo33e0szeeEos3zeei 7s0u 312 33248176 1FROoOzDGJcAeR 013355 0e33005400003334Z 6700 313 33426.s7 1FrOeO3DsJeAsR e133s5 ee3300750000I304z7 S6U0 313 03427 5 1FPOeOsDeJsAeR 613355 00336089000033632 6700 133 3336527 1FROeOzDeJsAyR 6133S5 003311160000331276. 5300 313 331276.33 . FiOROeD3JeRsR: e133155 e63311320000238671 S3 0313 23661736 1FROeO3D6J0A:R 013355 0B3311d5000033e7d2 2s0 313 33782426 F1OROOD3J6A9R4 013355 0e331176000033416.8 7500 313 334106.57 1FROeO3DeJsAsR 813355 603311850000331565. S0a0 313 331588.5 . 5FO9O9D9J9A5R9991535 e3209900325 20 13 325.1 443 . C00831 TQ ER RRLCOIET) TOON STUDY TTeemck Ties OF 5 F-352E3ANFC-aa3 In RTS EFE ooRn TL unesRSE0aSF. S0-R35E6 sna . weer s Esmeoseac uusiaesmseGsns S0 L1b DRoTonEwotnminsisiaeaaRemesaieeRene3 i41ht FHmpirmnkieiiGeifneasemnnnean3w8 b1ht r FRWoSNotETeusaGiIiuai doNusRsEiEn enir Elf1bLs mrHIoouementantiIiiarumdeeeSeeeREsabbob THPThohiaoeetre uiMsit:tiihcikoenemenmres& ht 1hh mFHTioeEorrrTeeaLnfTIatagiimmseeeesEsnn hfohfsb mRTFhoeemsrimshniiiFiaESGEiiEtEveenesTREda fL4ht TRmFoieeramamisaiisauanmstoeesmanaeyseh11bt DTTfomoeimoaeat3I G4fu% nsSaiimsseesmemineess ldEsam fbBt rhmFoeeoetmr asnisitpcaisrisaseeeitsnelate ht Fhg reoUmmmaaLitg EaaEmneSsnRmi3Lnd L iL . mfoSoReoiEeaGGEiIfsCmGoNaieEneNstEaa fbhte EsAme B= =e8 b EmEErHiS 3 F= 3H EEp=isSHI a = 3 5 =ox8:i3: EoEHiHi. E2=s3 3 = = 1 ==e,l E== 2H: F=3e:: 33 F52H2 BEST COPY AVAILABLE 00832 RyLotaEoi rGTaE UmEsNeRyB ELob HmPPohUeneR ssiGEiiaueaRmveeeEsesEaLhbx LfmmeoeEnmLbasTueaummemEEEdgSE 441po. RfCDioenEne aiEasiIrhuanmmneeeeenll df4oLf mfRToroiEmtkiee iaNaifsaastlmimeeeuientatEgo b 1 mDHrUeiiTmraaseiitaaaagmNeeEdneAliLL HDfGieEEnnEmeagGLtfiudfumosmmeseesdw rfbLof FTfDiiEonarmeeLaGLifIidcaaoNnmseeaennnnse nb)it mffE aeOryeInfbfEe ueImeEeeEsnEbh HdBmEmoimashctoiaemmaneennrsoeRL40 HCTpooEoEniEeaiGtEtnaGhemiemsmeeeen 41ibt MreFoatoirthweeeuadrsutEtoe esneESII L ht HCfDoiEiea eEiGilltuGGmeueeerenm te 1hiht EmFjoimratemaumtave enemsennzSe L he HCFLoeemoaftmaaina meeen nele:LL oFCDiiEoenSea ilf ECGemenenneeeneeaefi4 GeTE u bs emeee 4b ==3.1 52EEE1:i zE2=S38 B= 233H #e2 iei w3Fa5s3i 2=oi=3.l 2H=ie3:s3eio3%ss: eu=lse3 nEBPsHHH ==2.2 5p= Hee2s:] 2=5211:3 237 n2i2:: BESTCOPY AVAILABLE 3 3= EdH 233 00833 fee SE owen 5, LE min i pr EH fe fr saline FH ee EL wl I tfoimgEirE eE amennE sym2 D fHoyoeeI m unmes el 1% efffoooooreoniiesns Sgooastissmmeeaesmnimrerioiae of 3 fFffoooootiiiolee S1g2tsp tamomiimemmneeemsra 23 & Pimimtmnn rEoseie $i23 pniimeeme 3 I1 Troe of muses my#ee1es 2= 4: B2mnre.et ===z,s Fr #h2e:2BESTCOPY AVAILABLE EH CC0834 mmEimmE fo M1 Degymr yr lie FRPoeunlagli r rE E EBmeEpoEEEamSmmEnmEss E Baid esoopyayaa C00835 BOERS 8 SHonuEmnmEREE T 1 ooi TmeRnEuEs Ii mS mEEaHaEEmErEEsLd[0 pEEEiSr smEtr EaE | 0 HEH ERnE | BER UEREE CE emake 8Bi mOaBe O2Bi! BESTooRy AvaLARLE Wd C00836 FiROGOTDEITE4 1G3I5F o0z277s7e0e0i3s4z2 s0a0 133 F1OROeDsIEArRs 103355 oa22sresseeessetzs 4700 113 F1OPDOO3I6A7R6 013355 B0e2m6i2e0o0d3e5d6 1100 13% F1LID3I6R7R7 e1335 c0zzsSldcoeus3eezl 2400 313 FROaODrJAeP e132%5 oo228esseaeGiI7EET 6620 313 F1oFoeD3JsATRs 1e3i5s oo2zse7soaeesi7cis 6500 313 FiORDeDsJsAeR e1l3f5 o62z%ses0e0e3s6T1I S3Oa 313 FiOrDeD3JsReEs e1335s oezzssizceeesizcez 170a 31% FiOFOeD3JsAeRe 1033%5 o0i2w5l4c0e0s4s0i5 eSoa 31% FpOoOsDJeRsR 613355 e0z29s5s0e0o335s9z 3200 13} F1OrOeD3J5R8Ee 0133S5 o0220S870e0e335s2 8200 313 F1OrOeD3JeRsRs 103355 0e2390%000e83348l03700 13% 1FrOeOzDeIsE634535oz0e3t0e2e0s0z3s%7a7a 133 F1ROeOsDsJsA?R 613355 00l3003400e0l3e7l1 2S0U 13 1ForoepzaeAsRs ais 3 FiROaO2D2I3E3 o13xS oelxeesreeeoznsaasi2e0 313 F1OOD3J6A5R0 1e3355 0o3liecseeees3rsi? 4s0P 132 F1OPDeD3JeAsRs 0133S5 003311120000334016 3100 313 F1OrOeD3J6A9R2 013355 03311430000431030.2600 133 F1OROeD3J6A9R3 103355 003311650000344083 8700 133 F1OROeD3J6A9R4 103355 003311870000336526 7200 133 1FROeO3D6J5A5R 01335S 0@331z9e000e3z7s6o 4300 313 95899938 55 eo ;3423 e 63726.47 033a6.11 336621.42 33768766 367616s 7e3iss 333376162.71 s32s2s 33696..38 335421.72 338309..73 a3n3e7 3397.172 338521-34 7357a.4 43816.s1 a31030.62 43043878 3266227 03763.4 449 C00837 . THO YER CRALCCIET) TOX-ONC STUDY OF FH-352EX4P.8WFoCz-B1i4C3ReIeN1ZRATS TTOEOCRHYN-ISCIAONATIENSIT6I/A2L/S8S1 fH RSOEOMONF URMAETES.S5 0M-A3L4E0, 6-338 WEIGHT OF FULL FOOD JARS SSOGRAMS. eek F1OROeU3J5AiRs 161155 eeeeee1e0o0o3d%z21 s3a0 111 F1OROED:ISAiRT 1G1i5s @eeeee3zeo0e3ssssr 5e0R 111 F1OROED3J5ALRE 611155 GGeoeeaSs0o033s6s3.8700 111 1FROEDID5I1ASR G11155 GGRe0eS7oee0A3ZS1e 630a 111 F1ORUEDIJ5A2R6 611155 GGpoeosEeGeGlAclee 4100 111 F1ROOOZD5J2A1R 101155 eGei1l0cGeEi3z7zE s3a0 14 F1OFOeDIJSAeRz 611155 eco1i2l0eEeI37sSz Ssa 0111 F1OROeD35J2A3R B11155 0e00115d0B0e2d1z6s 6300 113 F1FOeO2D5J2A4R 161155 GGeeiisveeeciiseIs Jaa 111 F1 uuD3I5A2R5 16115S Geeei1sseeRedieslz 1100 111 F1OROeD3I5AIRS 101155 GGeezzeioeoeizeedz SSaa 111 F1OROeO3J5AeRT 161155 GGeezezsoeciitees Ssuu 111 F1OROeD2J5A2R8 611155 GGe0zzdSeoR0d3lsde S6oa 111 FROeO3DJSA3R 1e1i5: 0Go0c2s7e0ol0s3s2.93120 111 F1OROED3JSAIR0 10115S o0peazsSeEeEs3r%zE 2300 111 F1OFOED3J5A3R1 11155 oeo033i0e0003378i5 250a 111 F1OROOD3J5A3R2 1E1155 @0e033320000336956 78Ga 111 F1OROOD3JSAIR3 101155 GGe033d5eee0d3s7s6 600 111 F1OROED3JSA3R4 1O1155 eGee337eeeR3ae3r2. 78a 111 F1OROEDIJSAIRS 101155 0G0e339E0E03349L3 1200 111 F1OROOD3J5A3R6 161155 @ee0d4e1e0a0337806..1700 111 F1PFAO03J5A5R7 6111S5 @08044320000336550..2300 111 1FOODiJ5A3R6 161155 8co4d5d0o0e3d5a6s. 1s0a 111 F1OROODIJSAIRS 161155 860e447S6E0R339223 650a 111 - F1OROOD3J5A4R0 161155 0G0o4d3E0O0G3I7E54 2600 111 1REIT41 615 6e5EP041Z 50 1 345221.36 338675.98 36e35.87 3a5z8.3 43600 14 3s776z.36 337952..98 341286.36 338653.93 3de5i2.11 338438s 33758.89 4351045 338239.31 33792..32 330761.25 336%5.7 3ao7s6.6 344372.87 339e31.21 338760..17 335606.22 2a5s0.s1 332932..26 REST COPY AVAILABLE 334671452...625 00838 RAL E, Bm FreemwniUEiSaiEnRaeRnEs wimow UE Sma HHmEoRE wMueeEspUooEmpReeEssE i Hew LSE BE SbfreeemeuLNEEIRSSRESE Go ERRE EEEfYe B Fo o r#==t1 E=3==i,i STCOPY AVAILABLE 451 C00839 pPrr roeaisnse i3un1yg% g r whee e e 30 3 ht FmfEiaberT re UaEAamGnaEL seENed REEhLi Tow MENEE Lo mGVmeoaRiwn M3Bn4E:aINMsuEmiImeeNEnsNnRf3Lbos WFWe ooEdEiEm e EaEst NSw WARIeEEGSNEES fBk e GHr rieeedt a oEff Sne e eeiadalkk3e Hr FToriieicniaecee :t Gi3iEf:FdvUmaaeseeeesefo 1 312 PW WR oniEeE w sIiE NvhiEeeE rnRiesnELff1&2 e E mmeE ii mmRuat neEennsnRffkL oE Ff EiSiA t 1a5 MSE p hiween m Ef1 fE ErE aEAgE i Ni INNEe eERERhLb!k Fmojoiteei1S5E:rG beila sR IonGwEi)ke fWnToarARemo1AifE5f mG aSiiinvseN eeetaRss eaa 5L3i FmT TSeEimoIiosmuvminm GdNeRRsyl 3Eb )fL22 Rii mrosEaEen oLGGftfEGMEiNOkENeNEsGEDa 3fL FrETooUtiseRpB$E5fp5 CShaeinvnsees a 8 f33F2 - frwmiloRes 5ESE2EE UhuAeNNeEEEnRREfEe fLfBF: = uHHrSie s= @5Hi El B3[i3Hl] #iBE.31 "=8i,: = 3 ei 5 28 =ae wF iiee. =Ei H:ei w=HBlies EF5wo1Hi =i F2,H p== =He E@Hiree =mis. <TCOPY AVAILABLE = HpHEri] #1! 00840 He EERE Se ee foe if dems 3 in : Reman Hine EAENEE 2 Immamaame ls 1 HTmemin aEaLn mERmEn nR nEff EDeemmasslmENeErRinfnL TomESNEEN b : rmS HRwiegEmhEaeE nfnfL Emma ob i 2d we =&Bi amie m3 a =iii1e.3 BEST COPY AVAILABLE 22 453 00841 r LF0Coias 6ais UwLLaI0v03sS0 BwOaXe sweas Fiofoebtaieek: 16c2 beiciizvbeersisss ssob FoouTnR 1% oildeodsz 10 11222 Beze2s1e& F9iO0RO3o0cnTeaAssR o1bz2c5s Goodicbowweaissss bireoies sda iz 60 2 HfrE: 263 LREEEoISnS Foniiw G1F2 1: GOazirizesgeecssistaae 033a0 21a22 rG3ei6ss3 iFLROFsUUnCEeIGeRErE 51G32I15F Gbioiaztomnoaiesr ecibeie 0a0 a 133 3 firie 361s FFGOROOoO3UIERaRRS 110353:5% ooiziatsepeeeriszs oicdoess 1206 63 313 13 a36i52 3528 iFiroReuGsbTeiitndees 6133:5 Gi: oeoczisizersooooensssetszee saon 30 313 2 FS3ie5t3 FiROuGSoeRtRa G13355 6ocesrci0e0a3serde 3300 FoooieR 135 bizzoesre 20 43133 33770:433 iFiORrDGuLzeIstR:eR a135: 05 oooriesoenciscess oaa%eezzr 0ad0 30 3313 3366s 333 FFIoROoGOLDUJaIA%RRsR 3135%% 13% obooiireebooersesn bieedtd 00 30 11333 36a 8a 374s iFRoeGsoeTsosR a1355 aoiciascoonassecsz 2100 iREIen: G35 oiioasss 20 313 3 631231 3952 FF3 ouuloeIiSRa?Ek 6133%5 135 Gbociaczeoonrserss baisousez 630 80 41322 s32e3 326 iFLROREUESOeSItTR:SR 6133%5 035 bbdociosoosuerre 0iireesss S87o00 3313 W37r6 58 pr AFFROOEOD30CEIICAR0RR G113335%5 bDaiicsveouesiesr biteonits 6000 fo 21133 e368e 7s 2 FiROGUSOcIcAiR 16335: ooiooozaobbodroess 2600 iReicez 625 029300314. 20 1333 1o346z..s22 FiROGO3DsIeEs b1i3s: 0o2ios%d6o0a4dz77 210a FoDIAR 135 ozsepaari sa 313 13 3a1rssi FioRoGosicaeks 133c5 ooaosrcooaosiors 4200 1Re36eS 035 0zsso0r7r 60 3313 33371742 FiROuOi0eJcAsR a13i5s coczeoivoeaitceea 28aa 313 FOO0JAR 135 oczobzed. 60 13 336%0 02 Ses 6 iFROGO3D6I6R7R G13355 obiecld0oeo2e0zze 530a 313 2a6255 1FiORRC@oD33I65R6cREs 61a23s55 0oa2ci6ec5re0e0es2ei6zr9ss. 291800 1333 2a38ia9.l:9 FiroO3I5R%R 1033%5 aGcasceoaoszress 0100 313 32751 FFioORnOGoD3jJ7aR1rR 110333553 o0622a77ra0z00e00e33r63y3 6s1aa0 11333 3335637s. 61 BEST COPY AVAILABLE - iiFROR0Ue3OeEIrrR:sR GG133s55 vb0iaar7rsaooooeeosaractee 68sa4a 331.3 3HF7oe5e8 454 00842 SFRkoeantoneoreise 0363D0% eeSiiicttoevoezssesiri 83e00e 3i3z c SFderis s : fFFRoronenoioireeek 0113335:5 besecessstieooseeedlsseisss 2S30o0 13133 7i3e3d FiLoRUoodzSianrHes a1Gi3ft2 oorsoscsiaseneeoesesscesdr TSeobo 1333 3aEo7s] FFioornnooGtsoaenrees 1a1i33s:: oooiciccoeereoooosrrssseie z6so0o 31433 f3o3 ed iFiforaoanbneocceehen 010333:5: bvbeeeessotoveoooirrrseeei 40700 3133 3 37 Fo J FFoosohtoinek 11335:e boressteooaisiess 00 co 13 13 i3=s,: iFj oroebineew o132c5g obresiceoessscse 6600 13 ee7ess F[FooRooobbnioeeeeew 11o33t5: oobiizsossaeecvneessrcsitsi S3aoan 13133 5FEor iFiroroootbnsaicecrs a1oi3is%s bobrliooosrtoeeoeorssssstss 5e30o9 3133 3 = Ei FFiOofooe0ossreueckee oo3ui:n: obciooosesdaoesorsrseceee 66so 313 13 3Hds 383.8 1Fo7o0n36-89 3 Jy i) 272 1iFFuguz3beiosey a01i33s55 roGxrioitsoeeoeensrsstree 13z00a Fuohink 135 esizeorss Sa 3133 13 35i0n1.e3s Bs FiioKkoeab3sI6sR5sR3a 31G33c5% ooGr:riaassscooo0osesonsrse 4s30o0 Focbine 135 Grisoesss 10 3153 13 Fpar rs #2 FiioRrtGeoZsIEsRSoR3s 5a13z35s5 6oe3rx11i5cv00e00o33ss5ns6s 855000 Fochie 135 63200030 50 5133 13 3F2%Hs] 3s 2553055" ES & 00843 Teoma ries< mm aim) wd mana E po as L fois us size 3 poh SOON 1. EEE resiusoumEe 4 iw = Hs E=S EH 253 BEST COPY AVAILABLE =: 456 00844 FROeDiOJsAsF e1l1s5 DEiiddds0e0e3d8e0s G$o0 1 11 FROEOID0I4AIR 4DI1S5 001144550080425235 4200 111 FROEOILJSASF 1G1155 0011447S000042052z 2700 111 1Fu b3i%n4es B1i1s5 ee1l5d0m0eeesaSzez ZSoe 111 F1OO5CISHF 10115f @oiisSiceoeodsirie gsoo 111 - F1OKOOCIIEA4FT 011155 o0115S33000R3d1z3E S6e0 111 RFOODIDTI4AEF 101153 e6i1S5e9o0e0z4a5s7 SEa 0111 1FROeO:D5I4Es B1L1S5 oeiiSSTtee0o3zEsds G300 111 F1OROEU3JSASR0 10115S 0G11550E0000336%5% 6700 111 1FROOOILTJSALR 1G1155 eGi1csz1o0a0d3e1sZ 2so0 111 1FOROEU3ISASRZ 101155 D0i1c643000034s1S 2300 111 F1OROOC3JSATRT 011155 0Gi1ZSSe0eR3diSrE 4I0n 111 F1POOOCDSISE4 G11155 DeiiESTsReEeI3IsZz Seao 111 F1OFOEO3J5A5R5 011155 e01157%000e0l335e5 2300 111 1FFOeO3D9I%AER 011155 eea17T2i0c0e3s1a3z 5320 111 RFOEOIDSISA?R 01115S 0ei177d3e0e033s5d7 4s0o 111 F1OOD3I5A%R 1e11sS eeiir7sseoeesszsss 170a 111 F1OROEDIJSASRS 011155 e@air77aEeReaszr2s 4e0n 111 1FOROOD3J5A6R0 G11153 e0i1z7e9e0e0s3r8z0. e40a 111 F1OROEDZSIEALR 011155 Oe1iEs1z000R342S72 4S0 0111 1FFOEO2DSJEA2R G11155 ee1i5siscee03zde3s sSao 111 FFOeO2DSIeA:R e1i1s5 e011s8s6e0o0s38r2s 8100 111 1FOROED3J5AER4 101155 e11687800003357139100 111 1FROEOIDTJSATR 101155 e119090000347132 0700 111 F1OROED3JSASRE 011155 10239120000337753. 2700 111 F1OROEDIJSA6R7 0111S5 @01199340000433534 3803 111 1FROeO3DSJ6A8R 611155 001199650000346218 4530 111 RFOEOIDISASR 0111S5 e1195870000345241. 3200 111 1FRTEUID5J7A0R 011155 10290900000433225.. 2500 111 F1O.O3D5J7A1R 101155 0022002100003444255000 111 F1ORDED3ISA7R2 G11155 o0220o34000e431s43.8100 111 F1OEO3D5J7A2R 1B1155 oez2oeSseee03dc2it 3saa 111 1FROEO3DSJ7A4R 011155 6ez2e0s7e000341137 330a 111 aes cae28 aErzz 3262s7 433546.53 3a7z0 i3s1t3e6 3382463 Eels3 36152.72 eas6 52 a3s5e5.3> 331373s4 339502.82 2337535 33537.64 3388476 4e2s2.41 33870.e4 3s77a. s 332473.s4 s37s9.s1 33872 9 4m121 3377327 43374.37 s3258284 43261139 43534222 432455.36 s24s2 BEST 43523.1sal 341671.33 3133 COPY AVAILABLE 00845 Bes ames 5 3 TMeEw dTinSneUr 1kL Trocos i Sm B TToeolr iixusmenn na b2 He mamemn f aman f Dem imme mEmEmameEmr L EEHe me a=: = ES 355 BEST COPY AVAILABLE I 00846 Eelam S EEaEaEs E P he al n oman 1 e EE e: EfE fomaamE nmomaeE easn 4 1 mEemsammmae F But EgiE E5i, =e B3i a=3=5S BEST COPY AVAILABLE E5H3 00847 nem mEmmE fe mnemm iimmmennne ofo 2 me HGfRarEtSasEgpanmdiaeemEnmeEfensAn L f Hew amen nb mem tiumenn L HHRoooletes mx1f: mdseeeann88 1Bb Imam 3 a Hava Het Symes tenn 3 b mR nEmRe @ &51. py Em3se: as 3% 7 BEST COPY AVAILABLE el fH me 00848 Fpoeoerrese oLnosS owierrsreonnzzEeer ereo 133 RFOeOIUSITAsE 1G1T:i o0r7eIaGd0aMzIeEz 1E0O 13 F1OROODzJERTEe 1G3i:f 0oz2i6a2v0e0d2s5z5.1300 313 F1.G.0eJrRrF o1i3s5 eczseisceeecsstdr s6u0 132 F1OFOeDzIeArRe e1o3s5 6o2i8i5s0o0o3d9e4d 4500 133 F1oFoEoIiERrRs 0132%5 n0oeeTsBe0e4c17Ss S2o0 133 FRoeoiDasAeR 63% 0es0040T 20 13 F1rOeOsDsIsAyR 613555 DozzSsioeoopsdeess 020 133 FFOeOsDsI:E o1i3s5 0e2zseizoeo0dieerE T0o 133 FreOcOeDsIsE 163355 o02z3s4s0e0w4s2s3s 2400 133 F1OFOeDzIeAsRs 163355 0o2z9e7s00003d7e1r S5G0 13% F1OFOeDzJsAsRs 10335S oo2zeeesoouuiiseer ssoo 313 FiOROeDIJsAeFs 1e3n5c 0liooiooaegdiecss 100 133 FPOoOiOsJsRyE 10333% e02:000z0800036755 700 132 FFOeOiDsIsE o1i3:3 aGzo0oas0o0n3s6z5e 2200 133 1FROeO3DEJsRsR E13355 0e3306r5o0e0s3e3s51200 132 F1OODeJsAeR e12355 e0i3e0s9e0e0s3s9s03e0n 132 FROIOLEJRLR 8133%5 003311160000336547 2200 133 F1OROeDIJEASR2 103355 003311320000337322 51a0 133 F1ROeOzD8J5A3R 013355 003311540000345388 GS0a 312 F1oRoED3J6A5R4 103355 003311670000430606 S8O0 133 F1ORDeD3J6A9Rs 013355 60331138006034811z 52a0 133 sssssessss 3s @ 3ze7e 7 3a5c2e1 3s8z5:1 3r84s6 30544..54 3a7s5.52 a36e57..12 3366s5 ear8s 345253.42 3s7o1rss 036788 S3608316 e37s5?6 37665 22 3se3z5.13 39805 3 336547..22 327215 amzs 6ae8s6 1a1523 00849 THO VERE ORRLUIET) TOR-ONC STUDY ToC TIS OF FIN-SSE E4 8 Ce 143eIN RATS Toe Ta ry nEa E TE Eu ede Se swoon eer & fEseeaezstarseorris iovuesesssz so 1 FSi Gi see fn ha siEas #3 eGPPoeiaialnc af 51rs sseee tdeeccinn ties asaa 1ht HsHHee rFFieSrtTair5wi1e: oe sieosseeeeni sroze n an tht esting f2eie3s PDFtooEisEntiGI1i1s%r aeodNlowa SsesEesrE0fa bh 1 ew#8ld3 3 FFiPoieosvtaiiees PRT aGo1i1f:%isoSailoolerseeeeeesisiencr nsa aa b1ht #i B3i wi HieovlTe GGOIfiSeoiiedeneiaesrnnidea h0a fEEHLl ETTrGeesEamiT: aGGiiiff eooliuilsemeeasisenes Risnb fh1a Facts Gi oiiseescs mn ha =E=is: 5 CF[eooitaEil Fe a GGiif Soniiitseeassseis i ens Eiteb 1h1t bh 3 Ewii m3 PRPoeNtsieTotn SOGiEE sGtiiEseeNeisIieEdna nt "SEiise FLFo0oo0tt3io:e siaiiissi oisliiitdseeeersrreisetfaeo bb&tt iPesste ais eiivesars da E5= 5i2 EFTohocesososaoolmnt SGMiiiff Seillsseseeenscsss a3aan h1htt EEitS FtTroaltisiotraGiiff odiietenesis sa &ht =ETNl r Poco 5t 1% shsee enes sa ht 533 - iF1PRoRoOoe3sotIiaiSeeIekoS 6i1o1i1sSs5 e0sG1iil3ii7ssi6c0ees3es6sse3es. fed4aoo0 11111 3f86i3re4]aBEST AVAILABLE 462 00850 FLLoFo0uUSIeonse o1si1as%s oboluiasidzosovenasitesere 2cTao da1u1 iFLRFoosCSneai0cks o10i11s5% aiGiisiesosoannsesss SS7n0 014dn FFLoosOiien LG111I:5 aGoildseamceniis:tc l 2a00 n41 FLiFoowtiscier o0011i%3s isoiisisiiesoeetstirr si2b0 nh4 4 . FLFhFooOocSCiSinImeEe 181111:55 bGbiiisvsseiesoaseieczrir s3ae00 31a11 FiiFpoaoosstisitiesc 06111155% biGiirsiceSoonnniueci:ar 452000 111 FFiooPooauusoinnaiee oa1i11s:% booiiicccotioonnniiairscss s6sa0a 111 FLioFPoOuiZtiSniIie:z e1811i%%s oooiiicccstaeonesetaascr 1f20o 131 FiFKooooototsiiteeae 111115%% iGoiirccoiensoesiiiescsis 6sse ia4 iFiRroosaootee 011115:5 oeaaroaoososavcer d6o :111 FiFPSaCoSoGTiir 161111555 oeeiiirrrszaoooowanezsss 86soa 41a1 LiFFpo0ovsSaioteCe 61o1i15s5 ooeaiirrrzisooebonectssss 84r0a 111 FFipooaLttiaomdsen 1o1i11s35 oobiiiorrwtseoennosiceisses 4Sf0aa i43t FGiSFPCoSCiSIs:El 61o11f53 dOOiiiscitseeosnnitiscieas Bosade 1111 FiFPLOoU3sToiEt 811111555 o0oil1osiseoeose0sseresas 11S00o 1aa11 FiiFFoouoisssiiinas 661111555 asoilroseteonooaassssre 832000 1111 FiFrEoaoOsbbaiiinRcke 11111555 oiiio0szi0oe3ee7assass 404000 11111 FiiOpRoaaossonsnroe o63i11s55 Sooiiisosesiseeeoosisesssss 67700a 1111 FFioOPo0aCunITdaate 3B1111355 GGDiiisseeersoeeeosseessrst 2770aa 141 2iLFO.EOIJCSSioTnSiOe 6111111SS5: S0lG1ilo3oow9lmo0oe6ee4iss5sse7sss. 6ssSo0aa 11 i Fi1F0ou3so5a7in3c e1111%%5 SGoaczeooactcoeeesisaessssr esSaoa 1141 FiOKSeiidaiTee 1611%5 Seizeocrooosiesiss d5aa i4 3fi5Eo6 d2 pwpr ire 3 fSeea i a5wEmsLe EF5oaE a i3e0s2 sfrzei 3 e3fe0l8 E35e2 e70'.ls3 6a60ess 3=F8oo E= 3e58 EaEesa rF0oe5ye iSeoes3 SfBeaest eese7 WSswee?zr p4lur5ei7s.s6 BEST COPY LE 3Sd8isd 3E56s2 00851 Ffwooutmn LiwiisIbwoovNsaesEeatsS0vo 11 1 fDeoErrTttS SeIc N NNt E ER EADif FFCualllm1ia sEhimNmeeiEere sn2e oh4ts HGmaaWtth Ganifibiiitiuaomwee:ntson 44Po HFetiiiitc GiGEEf GSbiteeEsemsEssS7 dt GoLReesNaics oE3fAbSuRosmsNeecrEessRSJo 3&2 FmFoinset 0S 153 SbEooromnEeearessR0to 81i2 emLhsRSitEoafasteoseEansniz T sbL pDforiiieenLgf bodlienmeetdne 1IB0 ki ffeioiretnd S6ImgiMmneEs EsNe 5L SiFiUniiRs oiEif GSbilhmmiaemcmaer f0 bk1L ADGRrECoR:ttbEoERoiirtNsieseEsessr 2fE0o L33 eFFostootriehe e31r5 Gtohaiisesteia se So i i fGrrosasstems oef: britsieestic toJ 5 GFFrooeigbnainnt:e Gi1iff DeniimEeeeeInsteTes Y3se 2132 LFTraEobSsisSor 81oc35: booiiiazeetoeesreisse c0a0a a:12 FGFrooeossstse 1G12Fa% bSsiiisfsseeeosersseeerse sesaro i1izz FiiRPooosaoisooksn 16o5a2:: sobiiizisssmeeeeeaissarssr ssva0e 12i fFFooromoiionegee 1a2fg: eosiiaeceesevtesksiaeISiizz FE GIoecPtioiEom cm 8G1E:aSooiirssvEm eansnaEinssNfvo0 3L232 . PiARfGlSs0E 0i15fh% sSoiiiahsiseeaoiisseie ddaea 132 mIOENTE1mGaiEdEeamLa 812 =s=eee pW#F 3d = Bniid HWRidE 5n57e2 = =e:s wEol HE=ise i aill == Bee. 8aSe:ls w2Ei3H ia2ts E2 =de E=2Y. W3Hesd E=Eal F=#e, oE2H%e BEST wf#ol3 EEwHla ww3%li, Y AVAILABLE 464 00852 Dane r oo Pines PBEoEEEEREE RZ Seams Puen I HI a=EISTeoryavmuamg = Ei 00853 FripaSrpmEmmEmdaSEsaSEamERemRElyE Bm3Eii]H ffmmoomauamnegss 12Ei: Emri main:k 5 &3. . FOODJAR 135 823800356 90 a3 356.9 sRgEEmnE 1 pmemm SEER 1 EDupm EemeaEEme iEEimELneE li51 means HEmpaEeaEEmmAaEmaSaaRnESnsESgE 1 &t 13 3a&B&ri: BEST COPY AVAILABLE 2 &p#Ere7N C00854 EmmEsiRtmEmnn 2 E&ii i rere sn vas : +A2 BpESrTCOPY AVAILABLE CCO855 Th VMK OBHRLLGIET) TOS-OUG STUY Tecan TIALS 5OFmeF-35A266RFCE-14E3 IRN RATS fTora nyBedauTceIASNE CE ERE a SheS ssesens wee s P Hseiesr ens nmisIsewensnolseeslTa o4n FJHoiotik UE Si Grae sn dense ha bh Ft Hotoor Gni: cilo sesacesmda on TFa artiasse: o4di4f% la Sloossnewnrsstnaa 1bt Fohoionrsee GaUifiisslodlsewneieesn1ha h13 Pimecotneils 3a G1E% Gtildessedorrsess2f0a 4bs Hote I Gberse h Hoi 2 oie ea hs Fr iievire d Giif: e coiwmceernerr ea Hinman ee nn a Em h FTFChioeEibssisse 4i111E%s ooeiiiiiecweeeisesenesss Sa2aa h+hta eFTlroeeosr:s a8Liisfreciiaossimeeeesnassss e s4a fi4e FtFoooeobisnlek 51a115 eeiiswseeecnssensd ta 18 1 11 iFSReoeeostsesiiees o3af1if%s Seeiilsresecesseset fsfaaa 1h1s FDFoooeoossetew u131S%Ieoiatseeesrseosr an Ba ihist TE Nene 1 . GFLEeoercstis Footie a3111i:% aeiiinsieeeseeteenrt Si chibeosss n osaa bd4x os FTohoeosteaw o41l%f biiiesensiee nssa a1 fp=io =E=:li iEEi1 %#nel m=i.i: [#faeHHi = i =3 SE. &3 20:3 E35i33i n8ss 5& pid OPY AVAILABLE nEFSHH E9re3 EB&Ye nr5e%ed coos? LFuRos0iStAeaE G1isEs Oivsliieoowwisiass 0800 111 Wsweees FSFlhoootoitnnse 1G13i1%s5 Oablisvaieseoewssetrd 636000 1111 ifHeEe Pinaoliwen Grniefpibe ilsseooesesy 8l0 L4 EE=Ssa FFLFoeSCiaiinee 11111%S5 Dmbicisietoeoenuaisreesrs 53So d43a1 HpEile LFieRooovt3ia5naCkr 61i11s55 abmiiscstiioooneoaiessestt 8a8000 1a11 fswese FiFriooosthiaonueese 1o111i55s ovGiiisssereeovuaessseisser 166000 1111 3d3%5i1e iFilFFooobttieantske o1a1it5t obbiiistceoeoooeiuszezese 053000 411 3ss3 FiFLoROooCtiiioneck 1b1i11c55 obbiilccostsoeonsosaseiirss 232000 4111 3 wazi iF[rRooootsteaitses oioiiisfs oooilicscretooomesssieets 3s70oa 1111 Ee50ss7 FiForooabenianste 1e11i15s5 bbiiccesooooaassr 8800 i41n IaEsEas. EioaoNotjmSeek Ge11Es5 Gooiiur7rtzseooenonistzrsa 232000 1a41 i33070:5 FLLFooRoStuHiokeE G11i11f53 oobiiirvzdeeosooeesnseeesss a408 1131 3a =a FiLoaPocateejsce GG1ii4sf5 oooiiirrrseveoooimitesrle 2sd0oa 1a11 37f5es2) FSERGooonvoecny o11i11s55 ocbiiicccttoeosnseiessssse 252000 31311 3Hei2se GFioRRoOatSiiScnE:k b1ei1i:5t oooilicsctasosooevdaietarsr s2da0a 1441 ppFrrri y FFiooRooaobiijcneske 1a11i15f5 oobiilccorcteoovoeeisrese sG5a00 14111 3i366e58 iFioFRoo0o33ia5ni6kc o1oi1is5s oieiiszseaiccooeseiesesr 852060 1411 wEfets] FiFoRGooobsbisincakrR 1o14i15s5 oiBiissssesboooaeaadrrrdas s46aa0 11111 iH37E1e iFiorFoaobzsisinctke 61a11iS5s Goeiiissorsooooooaaesctss 2s2ab0 4i1t $pi5ts2 BEST FFuoasorhseie 1u11i45t5 oobriiscsecscoeevssaeecrse s27aaa i441 wEeesd FRihROoeIvsiSSnr:ke e16i11t55 bbbizsvvoiisooceeoiarssssae 6ssaaa 131 B3p%ees . FiFFhGooo%vb5ii7nnske b11i11s55 oobsrzooouctoeensaiscrcsys bssaaa 133 eE37s3s8 00857 pLsrroOernaTat wis ans SI ar 1 arwesds fFLoiOldiTee NGSESh SeClhlaadwkeieseste l l3a0 L111 #afri3d Ps LEEtANTiEErRSiEELo4 BE=EE fPmoiasieme anSilEiSbaaAsneGeeEirsReiE fo LY1 c EEErTl FGLRElGNEiS%CnhL iGGEsiE oSboicriinsoeeseoeantsietz aw0a 1a2 uibeh FJ Pootoitoine 113a ssaocahseennssesy so 7a a2 a2 f=r2 LFreonutan G12E% NovaEveIno L 0 F42 5 G5i FjFroCsltiSieci1gc5ai5 gsGourooeoirerantet 00 sa 42 12 E3Fee LLLRGOSSSSTCE O1G1EE:E SlClaolsmeoereises:e on a 2122 EBEYis FLFSOriSeiEsiianeiees Go1c25;5 Sooiileoesdweeeeensiiseti aosau 12122 HFWnae. GFIhoReinSet Gi63Fa3 tsGilooesreenoesineanr fssnoa 3152 38f33H FMioeicitOieetei iSSEF oSSilieisleneecsseerse;0da i21z2 WE83RE fFioeoeetty oFiFff aSounwnteeerauiisiG;eo 31fF2 E5 w1y3 Footie fSooie ai12S: ouisensco Suimert da a0 a2 a2 ==wiid t p FSEaTe 1t5k iee eere a iz 5wBE2e FLFoSRtETiT 16453255k ooSiiisccitieeeeeessnsrisss 31000 i2izz #HE5eE1d t FLOeGsisieneeh 1G2a%: iSsir sseseosnsss g7oa 1&2 swer8 FiPRGOsSaiSdnoTee 1o12c5%s: iSiisssssseeeeesnrssrsre ssaao 1122 2 5ess fiGRSeoSiieer: 16555% Sistieeeerrecre 020 12 iEdr FiFoGo3Sn: Le O1GS2oE%f Eto01i5seA3w0ea0eN3s5ss4s e78a0 L2i2bz E5z=7:ts2 BESTCOPY A iF3foelniSioess o1o3if%s oooiusdseeoeeiiisise 8sao 122 3uHses? . fiFtoSioetGss oSScfEt GSSiiiavseleoneisesess 22aa 2L1o2 we56td2 00858 FFeporniteed11a5 hbwprhaeedsaetel A10 li 1 MCRwILAIIaNnENNEER f f FW moneEia mELifcN m bimei oiT a et mefi Hp SRaoiiril i6ieEi sSspishmeseeeiesa3HA 2 13 EFTtoiolmn iOiiEff oStihioeeseens saa 1512 EIorattRiiit Fin ioimf:fuoinirmicassmceinamesrtEss1edm 5L5 2 mHLfuoSini oiIf asasihideneesmeinntsz0e 2 312 mFIERehiiTmgEEinaaaEmdreeEsenEraRaE 812 Lo alpfnorihioioLgfnf aSon irineed ess fa3ti 142 1 Er W moieceiT wminod:AwEcioEtE eenRst L0GSr bb PPeoEtntEiLs: i osduidEsoeiNeeeeEs Rissee 8i8t IHLffoniSoiteeSiles 6iaGi3nt usmSiiictmdsaeeseeasessseitds 5 3se 3 12 im FToTEorEiioaFt: ASGoiilImsseeEaeesnEnts Ln3n ib8i sa ne Teme Sb FLFrORroGOpSDtiiJrCAitSRaL011di2a2f5:5-b0ssg1iie3sos8rss0ece0roen3rs9rdes9sss. 35A33a00 12122 i . FFFUoEowENiiTaEi1n5AsIclNSosGseLEntEs LLdtlaa f38i2z GFRoEeE OfFf Smreeeasneas rlea 3ne #=E1id 5EEssH B=5o. nE=hse #Biri3i EE= 5es G2Haie1sl wm=2rie:. B=5HHee E=E=HeYi Eo&res &ES5rid HFi3sHe Em=es 33B2 E99sEH.3 BEST = =EEoel =ii . VAILABLE 471 00859 fHefiowSnri nrmwen aN vierrmmiiR sewJ xb& aWw#rneii E FTloee mlE lii mnaaN lnmnnaseE !bkf WE=ieeH Pw praiinsga 0 be eenA SO kL 0. f=a=eS Lt HTr Feoohl LpE aEiSuge EeReSwEkfbBb 5 BuFoii UeprmegaErgiaiaEnnEiaEennndbI foo 3 ==. Hi eumn EolaaemmeEEmnnina Bb Lb f8Fre5 hTTraReciE: ESGFIiiSEEtMReNEeErIEE2a f5Ob a= #e1d ophaewgpeiwc EReEnr RaE Bb #=E3:e oEMheEeetmaiEEEEIEeSBmEhhmeeaaemnnnEa8 f5b = E55s. 23 . FLReofmEilt 2GBEISSLNmEEeRHeE RS ee 5 4 5 f=2r: rTm eteHaE pNAeRrS Foo 1 ber m LRB bf 8 9rmen5 HiLTeenm EU5E5EMheeenkaseb4B3b =Eei8 1 efni eelt BEb2fiIsGnRemeeEenntNiEn ess b bf3F aEu2ed FE RHoeoiplee 0gOr:EF SRSoeeeemnss Em a88 fbb5s =a=#:i4t Reeltnlee ie O8alf Oi Shdiieemamecw d b5 pene A = = 3: - BESTCOPY AVAILABLE CTPiUelhRUBEeiIStr ahmeenNnnnsa 5Bhbb &a8 2e } i DiGEeD iSbIIeeSRrneEneSkabk3b =bEsei is seeet EGElAeEnN S a b3 25. 472. 0860 FDoeuleIRsE v1i5s wwierosweeesissme s en s13 - s3u5ns kFOeOiDEIrRsE B1135s uGleirTs0o0u4c3sSe ESo 0213 a33s5e3 FFOECIDEJrASF 6133%% b0izrso0e0e0iz1t4d 3400 312 a31s4a.33 REIDISREE G133%5 eDsiezleueasdssrz SaG 133 435572.51 FiOrOeDzJsArRr o1n3c% 6o2i8e4i0a0m3d5s3z 4300 313 RE3Es 3% boEte0ssr 6 3 pa352r3a34 FROeOUeIRsE 813355 b62e5E6T0o0B3a7c0s 4700 133 FOODIE 135 ofeozsi 70 13 3ac7s07a 3317 F1OrOeDsIsEe 613255 o0zsoes0e00zdSsa: 900 313 a30m.s6 iFFOEOSDEIEEL 613555 002:Se1cGe0o3iTsLd 04p 313 3a3m4s4 iFpOeCsDsJsA:R e13i5s 0pze3eatpoessistss isna 313 339795.15 F1ORDeUzsJeRsR e133f3 o0z2e9s6e0s0i3z4e34s0O 31,3 w34e3.e1 RFeOcOeDsIsE 1ei3s5 o0zzssTseaepiiztri SSO0133 3s7i7.s5 F1OROeL3JsAsRs 613355 oGszeseseoeasd7sid 0200 313 0S7411 F1OFGE03J5R5RE 1B3355 0O2i6o2l0G0G3A8L4L 5800 313 a38r4.s8 1FFOeO3DsIeEr 613355 003300340000435234 1900 313 4823481 RFOEOIDSIEE 613355 0e3300550000432631 8130 13% 3 \isss GZS 030700355 30 3 im2L36 3563 FREOEISEE 61335% 0o3c0o5s0a004s4s3e 460 133 a35a854 RFOeOsDJsAeR e13:s5 031000391 00 133 FOODJAR 135 03120037440 13 38914.7 Ect) RFOOeDJzAR 013355 00331i3d000e3d4e0s 2300 313 3ae4s032 1FROeO3D6J9A3R 013355 G8i3i1S6A0R0S3e4S8 B3G0 313 s3e4s628 F1OROeD3J6A5R4 163353 00331i760e00435e51 02a0 133 a3s4s12 F1ORDED3J6A5R5 013355 0633123000004366d2 2700 313 a3s6a272 sessazssss 58 e 00861 FA a Tomi--i--e ts Ra enEpEanLeeasE tHote bEeSe cans ex 10 mspnoeemlsaoirusie insaoNe nn LcSa fL43 nm LeeraSEm Iiswuear mmmenn L41& m E aBomieIiun tNNL eEe IaG iihe PJBfeooEtii S r oi vme er eenl he 4 HPfeoaieos iuH gIrtEnanRemaEnnbhLb . ETprtnEigunrimr iuemE s: 4 lEGeee pniiiiuaamaemnnnd idhb TTHToowegee iand lratsibhn naeenn &1hb eTmoeaee aihtiae eaanmlemnseineen&4i E mHoEemaa nia itaumm eemne bfLihL PR fBe oooetfnlmaeanaRiiuninln 1Lfb LoL suis 4 - ei TD1RrGe2meSmInE 8Lni61:l5ieSt01m3ea5hm90ren5e2en0.eea40 41f 4 SmaamEmn LL E2fsaarsS oa==t, H=H2hs1: oBaitsl. = Fi FSo 2 a = He SHiti3 = Bamiii Ho=ne3 i gaEeeHs ai3 =. i. e3 e5228.ds84 BESTCOP! 5 AVAILABLE 00862 iprucenas ge SriEs aweimu sew enWw 3h L +oHr.ds BEST COPYAVAILABLE = | pEfoeimigaurrE siuseneeiamyk LL ob =EBir,ey PhWmEamhLeLEmg pTiaE unememE rr eaa 4 . c. 2 mm=Ye frr eeeeiiMisEgGn tes mnLss h&keh nEiEi3 ea RTeanEamms 3i:rui aataennmeb4+he ==w,e ws pEhmEarERr aMhaiiauaaannmaemnmernee l4iLf 3 E= =H M TpOrhEteaE NSuetn eE eea tna 1he be uf=Eseid : tfr ioigLagl e meenan b H FF=2rai3 p T Toeeteih lt Hat EeUnEeReEwbL owowttts rEaarsmmMrEauumnrmieenf44 i &F5i) rnaTooesimtiiaoliraemeneeemsesnanf Sw=iii oTTTooeeewma Bhahlataemamsnmeinrieeshbhof 3 #=527s eHDmeriEEahaUfhtiua aamnemmEEL nnre bh1fe w==1.e LfTPoeenaeres noiUFSs aG taene eraasaa h&nee 8 2=E2Hi1 mHLioEErmelintiaGGdnteemmeeelenbLb4h mEHiies . fFe 1GRoG3iao57er 1 Gti1S5a arm02m01men 9e04mt5r7. SO se 1x 4FoF3a7Si.35 BEST COPY AVAILABLE me mEmlh on wl 00863 FbOuLtIsA AwLsE Gwraoesmtides 410 SRateTe aif ovsedi: 0 a111 FFLoroirstteotrnmee 1s11i15c: aboiofileeioszuoiiszesrss 1dm0ii 13111 PUSU rRaalESS7TEe 1GaiSEs WbAriSideseoenddezsres 2eo0nu 1a1a FFroOeuolstatmsk ins Al: aeboslrceeaciis:e So 20 a 1 iFiRoPonacLzaoecmcseh o1bc1i::s oooaicrdtieoswmhoiaeeszyse 4S40o0 2411 FiFOOrdbeUDniIenn:ek e1Aaz5e: cbbaoorrviezesenoeiiiTceisa 014000 2a2 12 iFSRORoOSrLCaJScAEsR ih1a2fs% pobuaorUEsrsseoo0asiieriss 7s00o 2212 FiFPooeouzoisieeaenr b11a22s5: boGoalvssssssanrszreszr 76000 a21z2 iFOROaCtIsReE: o12z5s ooliamzsseezsezse 5s6o IRESTr 62s b1meaiss 50 212 2 FLFFOOGUOICDSIIiAReR 101i22f55 oool1lo0oc5ds0ab0ni3es1iy5z 826000 13122 FiFOEOeDiIsE LFA350 5122:5 Gif oOllanrcesnesscees oioveoscs 6070a 221.2 FiFrOeOlOUoItRieE ooAocfft oobliiliietesseooeirisers 90a1 2i1z2 FLLFoCaMEiIIsnSekTz o1bo3o:5f lobiaiiizuteseeoiirsreess 97d0b0 2a22 FFioOFonitGciaiesnkae 01125255 ooeu1iiilrcsseeeaassseiee?s s06o0 12a22 iFiORROaeCisTsiAocRs ao1z2ss5 ooeiiizzioisssaeerssessrze 3s06o0 12 iFFoROoeUlnDisInengrR G41i33s55 eeG1i1sz2z34eocoe0n33e%ess7 33260 2 a2 FiOROeDsIsRoRs iRozaos 1oz2t5 eos oo1i2z%esv034szrs 6127a065 e75n00 2a2z iFROEO3D5I0A0R G12o%s 001122909900330768. 4208 FOUDIAR 125 o1s0seres 18 12122 FirOaOsCsIoRrE b1a2s5 o13290370.10 iReisoz aoc 01320037 80 12z2 FF3" OuOsDGiIenAegR: 11o52z55 oobiiia3igesessaeoszresszs a91000 i21z2 iFiRoF0ciSoiSin0ns%e b1oo2is5 beei1ii3iesrvesoeeisatsterr 77Z00n 2232 i iFFOORGGECL5II0RRsRk 01122555 o0Gl11i4dc1is5o0oe3ez6ne7es 65400 21322 fasaelvlee paes Fp3r red EEpieEs ipmda 3i3783s5s 22Se5z45 7Gi57 5627 33i72ss i3s5e5 E3r6r2.5 iaE2 7 6aE5ress Ep3eae af6er56s 3Ee78 3268:s a3365s732 E335e67 , 5Se6n2i irasee.t2 zEJaH=z:e BEST COPY AVAILA 6a20r77y2 7p3r9i854 00864 irr se sre 2 , BESTCavOalPapYg Eun =) Ful 3 sreefa 12 gt sz: BEST COPY AVAILABLE Ei C00865 Pr -- es. PESTOOPY AVATAT; Al pom amen 5: LreaEmimRasE E=C pp Y AVAILABLE coossd 8 rFoautl Lo boeseies RFeonoelrask oLioi GniirresssoOiMrees iFROeOSUeTrAeE G1i3f5 bbreelbssoessiees oFoliie GL3S5 oorceeizmseesndess RFeOCIerEe 013355 bbiriSiIsReAnSsIs iFFoeUlCeTTesE o1i3S5 nboreiTcseemsisssz LFoRoOoCiEece0 G1i3f%oorzsieeseeeiascis PFeOCOsTeEr G1I3F5 anezemesseedisesz FROeOiCsIeRRr o1i25i meCiemciesneistsea FROeOnDeIeE: b1i3:5 06i2s8EaIsebaeE0zs FROeOGSDEIsE B13355 pe223eTcIsReAnTTEo FPOeOzOeIeRsR G1i3f5 ozzoaemseeesaslzs PFOoOzUeJeAsR B133f5 0oiioo1evseeassses FLOROOUZISRERT G1i3f5 GGiiooiss0eza7de FiOPOoUiIiRoFe o1i3i5 mGiceeiaesebarsszs FLUaGsCeRsR o1i3i5 eOCiooerss0e3iEss FFuzOiloen o1i3i% ooieesseserdssss FLroGoC0SISRL B1I3S5 0ec3i1e1s9e0z4e0s FiOrOe0zIeRsFz o1i3f5 eGiciiizsseosveesz F1OrOeD3J5A9R3 B1I3S5 B0I311559e0542174. FiOrOaDzsJoAeR G1335% BGr3i176I9e0e3T3r6 FiOvOeUiJeAsRd G1335 GeiZ1i3e3s0e4s7d7e LFOrOrLrIeAiRat1s3% uoz0esee3e7. so 13 5#00 313 0200 313 ssOo 313 1s0a 213 ssoo 347 Sse 0213 s4n0 313 3s0o 313 6300 313 7400 313 3e0v 213 as0n 313 0G0 31% 030 312 sSoU 313 szno 313 1100 313 4600 31% 3100 313 2700 31% Sdn 0313 30 1e3 2sa0s%s dSsas g S8150 2 r46e.8 a5s535a a5s2s8 a35s3 a62ss4 3584283 seeaes a3r5e0 4 asze:6 3650.38 3742 d3a5z42s Esads p35e4d2 eie 11 a3eE263 saars a33827 aSenesd 73 00867 TV OnLILY TOR-ON STUY OF FIISES + FCnad3 IN BATS T TeIcSTis sw STonEneRtsI 0eSReE ssaomns EsreMe AoisIsNoAnEicSEsn L1 rTfooeitecf2iti mwimeoann sh ge bt Tain GE ete te 1 i GE er ht Bow BUNT R 4 PTmfouiRTsEe L3bGiET: acbiehmieaEiaint n8a ht iha pTEOecgMgoaMmrisomi hh HaTeaeamaMNhItINiENdReGS Lf WPTFooisoReiiewl4Hd4:t IISshMeMeMieEERare bt bt HfWreeei MafII r UMEESSSE }4 FJweitRni wEis ccNimei Eeey 5 bs FfFOioSsittieied WE 14% siweaet 36 A14%IAsiNamIoeIcsEL0 bs h1t FPiReE a 3 em itig s 8 ba FGFuRoEuoSlsEAeSR G1i12f5 G0bi1il34to0e0om3n5ie5a 642a8p 11 br ELFoeSseunRiaw Eo14If% EMmiiRtsSeessNEvsea L1ht suets #wEy5i: is 5 1 Eii.2 EEaaH3 Hf5e3it = EErI 85pS. 55EH:: wsf5reehs oHle 3EE8ii BEST Cop n8w3ls AVAILABLE 480 00868 shea is ves se 1 GUE UW NNERE 4 Pi m WeearAWGAfnwENEReEEEt nEiLhh fOpirrosEeetetd eId Nps orrEeee SniTdElLB4Y RE nian SL HFWOOOeUJmRAR iR115Uf G1NE60Em 034S6. aE SO L11 PmFooene LEBaEsWSSiiEeeNstteRa Dhha Pm AEA eb ft SFfaEol B aaIE aSdeaesn E lie iLb FHIriiEce1GMSFEgSSsiewte ieets w A n4 Fbeitenle? 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COPY AVAILABLE 5: c00871 lawn udNE nL fo E E ele mEe r Ere E n oLLbLL W#rii1 Ler Be BE foarwi GmriiioannenaeelmeEndLLbb awoiei ECrRmIssiaammeEmmnlbLb SFoi ToReeawrd: GsEfibeedseesriEa f&bh uwfreii rReiewamgsseiidaoanmreeenndie FWneas Hi Hiene S uCf iSOioReEtEa b Te lames nb mmwEiiti HpFewmmsEEegRmeeanRnsn oofb 5 =53i Kr Tiehmm Eaadgaieeenm tSELh ww=eiii m HTreaiovti e av3iridiea lneenha bBhb =niis: SHeoemwminniaasmmmeeenmnnlfoo 2 ==i hITeiemnis noifi bSoowleeeumsskSmn bb H[==sH tJirigtattee knb mi #33 BIiPeitriice n4o3l%ioooieinereseoemmrc Etda abL4 Tracts 3 Sieenb tab Eop1+ie oFeooense f Uiff ssoeinamin e 3 b& owWnni PC GeEriEs E moI omn Sen hbb E5 wii EMFoeetmo ii5ibbeeneearesrek mb b8 . 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FJ OCJAR 128 G1sceeieeer0I0 Fein 0% e1oreezal 122 3So8s8. 2 aie RFooo3oET3aSR e12o:s eGiiascseeeodidsls zsua FOODJAR 128 ezeeoedis ga 212 iz G30615.62 aia TRAIRR B26 AZI00475 20 2 arma 00920 FHfoiintoetdrSaihaspswireoieimrniensn sS1ur0 em Rane 12 f12 rPmLeoEEmiEsaRtEGmEmSnERGeGEEeLRnfFLf4 SELotEEieMmdEEeAAmRIeRNiERn ET F3o. i HfDhokEoaSEfeaiRmeru oEnes a0 L 32 b:e D HDHoewEmemimGmaiEammRmNmSemeSrnEEfLL G HDHaawwmegsSimTisEEma EmeRSRSn mnLfoLLf GRmHoeEmewmgsEGriIrEEaaEEEmRREEEmRmRLRE f3Lob mfDHaEognEemegSsErLEREEmEENeeSNmnETneE 3OLL HTLoEElaEi RGEmIEIaERREnEENLSL fSOLE fHGBaeaEwwmmaELEiIEEmERRmSEMsEeSINLELnfbfLb eR HDiawvme m gigFaasmhims eEemRLwy!bO2L mFtHoeihOimndEeaafSgtTresEaaeEmmeRetnEenRnI6bOL SHefoehsemaett g3Gm3rEEEmeREmEnsRDalnLb mHnHEmeTRE EaHSfrIraaedmmEssmeRemNnaeeEns1Ea 3b3 MLHioL mew sSST tieuaEEnlRmeNRmEEEsLffLLb oHmHmiET aSiirrtsGnaeemmnennts 44Bb HOS GEE E Lo f@ s1eoe pmi Er3i4 iB8io.e w= =fHes =5 EE2: Eemrei7 = = &1i E= a1li EEwEiilH & Ha it = a20ls 1 i E=Hi i SFEeaeHs = EuSt3 @i=H:iii BEST COPY AVAILABLE G= FindH: si 00921 EFoilsliriee oio3f5 oGlcoseebsbiiiede T3u0 133 Foote 135 eiroseize do 13 SE364ee2 a. 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5E5d27 aBeal PaSroe Smo3s4 &3 a2 SFE4ey3r4 2Eoa 3 EEstki E$Enea 3aEi7ess eE3&dr3 2s32e.9e0 2s25ss 6E$5o73 sFAsi BEST COPY AVAILABLE SsS7ae0r5s EnsAess 584 00972 F1OROED3ISAPRS G11155 b6z2e0s8e0d0s3i1d37d0o FROOOSDSJTASR 101155 002311010000356410 968 FROGOIDSJTATF 0111S% o2z1i3z0e8e5s7r4e 5200 F1ORDISATRE B11155 002211450000357655.. 6260 IFORUEDITSRTES 2G1155 002211750000537534..620G F1OFOOD3J5A5R0 1G1135 00Z2i1s3e0e0i5s4s5 z7uG 1FRO@O3DSIEALR 612155 06272100000537765. 0200 1FROEO2DSJ6R2R 162255 0G6o7r3z0o0o43is1e s2u0 RFOOOSDJEASR 012255 000077540000432930 4200 F1RoEO3D5JEA4R 012255 0o0o7v7s0e00436s5s s5a0 1FROOOD3ISAERS 1022S5 0000670300308556.6 050G FROEOIDJSAER 012255 e01i0e1e0e00533s4s 50a0 F1ROED3DSIEA?R 012255 0@1100320000434711 2600 F1OROeD3JSAERS 102235 opiigosseoees3esls 3saa F1ROOOIDSIEES 012255 001100570000348799 240 F1OFOED3JSASR0 012255 e0i1o0s5e0e00s0r0z 08G0 RFAOTODJAR 125 01110R0G03050900. 00025 F1OROOD3I3A9R1 102255 0G1i1i2l0c0e338s4e.. 6cGe 1FROeO3DSJOAxE 1622S5 6e1111d30003075545870 FROOO3DSJSASR 01225% p0i1i1s5e0e0s4r5z53720 F1OROOD3I5A5R4 612255 001411876000355415 660a 1FROOO3DSJSASR 01225% 001121090006349590. 2504 F1ORUED3JSA5R6 102255 @01122120000537621. 5200 1FOROED3JSA7R 102255 001122430000440646 4500 F1OROGD3J5A9R8 012255 @01122650000358141. 4700 F1OROED3I5A9R5 102255 @01122870000438796.. 640a 1FRO0O3D6J0A0R 012255 00112390000043547.4 5000 F1OPOeD3JcAoR1 612255 e01133210000356581 36a0 1FROOO3D6J0A2R F G03 102255 625 00011i33343S00e00e35s61i25s 56a0 20 F1ROGu3w6J0A4R 012255 001133750000437729. 870a F1OROOD3JEA0RS 612255 e01133380060437962. 730a F1ROOO3D6J0A6R FOO0JAR 012255 125 001144010000347396 614208413. 8300 80 111 111 111 111 111 111 121 1i22z 212 2 122 122 122 122 212 122 0101320000062 122 122 212 212 212 212 122 212 122 122 212 122 212 212 122 122 531153..47 S36e1e9 537746.52 3se7s. 2 5375241 53485..27 3S77562 3a822.5 43920324 438863..85 s3e8s5. 3 353646.5 43471162 3Se%is3 436799.42 3728 NOT ON 338944.6 3S7a5s..87 437925.37 S3465166 s39e9.s2 357621.52 440646..45 S38141.47 437805..46 3475445 s2i23e 35612536 35719582 s39722..37 347796..37 aa6z STUDY BEST COPY . AVAILABLE 585 00973 fsMDooOisHeoREoGEifs GiuAsdsnNeeeeSsezaEz EeEsna f2L12 fPEeaoEmnrGdiEEEuRuEmmEeReRmsEeSEE OL!foL mWmeoOmAeLEELuNuGNGReEEEERLILSRy:lOLLo RFr DieEeemi GIiE: ucc amiEsmk ne E0E f1L2L HERmoegEed ESSauAUNmmEImeETaELf2LLL CorRtUwohE GuDEaNElL f amen EL Ree nwse EAEEoluht uenma SEEffLEN W RRoEwLEAdIE m OTMESE NIEER F3LL RErrsrEes EEtoimEnR f NL rEFEoiloElionEp125 peusbToReeNEseEsSsrESoah: cfirda0osann sa mEFprEiTiEgEoFeNEngNeEnEsRaNs EELE b fETeocEEiTmaoaamlmmeilnnfO5L FpRporrioiiemGfaiggrnenoetenee aE 12 of RmFEoentmEeessSaSam sTnean eIms i4Lf412 RF RGeEUlSRtmiEdmEIaaREmnERRReeN se dame LLfbL rSofRreeEiEAESgEamEGgNaEaEEmNnNREREaE 42 L3L =s=Lse EH22He E. Fl3H n= $5e3 p2aiendd EE#iri2ee ==EeHS3 #Fp5E3i 3 f2HHs hS:5o0r0ow smo 3 wF 3l = EE3aH SE @fres] HEaE-Hil) i2 8s5:13 BESTCOPY AVAILABLE E= 25H33 wwti sss 00374 . 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FIOROTDCJSATRL 1REITT2 1G1155 B15 661177450000632545 617500575. 652006 1111 358284.9 575.2 FROOALJTAR A14T5S bmiarrae0ai7na m7b 11 3E7o47 590 C009378 ) m ReiATL NEESEB E5. mWEwT a AINN NEN LD |L = EH Costar Ei mELNIGSGRE FL Id redFi sedRtmaoE MfuISiEWa ENiHRGmEEn RnENyLREL24L =E5i.H =i mFfTEeoELwnIEdAAi Dest aSTRImUNEeREEEnDEbLL URnn Rf =i FaiH = mROaSiE INEE :L 7 a e WmeTEanEAEo EUMRIHNEENGEDL44 tig pl TE "EE3iHHs 2 eMopOoolRmdsiE SERNRS ieEnEmE 3OLL Ee L-E3350 G2 cuodesson a0 =i :2e: or on sTupy of LFottEihRr 12e5NrouEe tiiaRiSnsI5a" A1"OR mE EARNER EL CSa :Eeas Be fTceeTEem aaEAEEasRINIEEtSRIEIESElL44Lo FestiTammn nf Ei H1i = L[foeiewm iiSEE nfCSaHrInE EaEf4AL fee = Sele kb == EfeeHr] = eprEeetEyEEEEGSSHHEEEEERNN E DDTA lL L Iriiags of Sitmenan se 3 =FswSiye 22 5 BESTCOPY AVAILABLE fI oHfeoeEdoa EEe2EGtEn RNeaEIDlEEE Gb4LLLo 3 o=Ei:H 21 . 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