Document x5OmNvyLJnBmvwvRq5EXoxrp6

APPROXIMATE COSTS FOR TWO-YEAR INHALATION TOXICITY STUDIES ON TI02 AND TiCl4 (18 Month Exposure - 6 Month Holding Period) Animals Initial Cost Maintenance 1700 rats x $2.10/rat 1680 rats x 0.08/day x 730 days (Total excludes rats sacrificed during study.) $ 3,570 87,360 Analytical Development and Continuance 1 Toxicologist/Study Continuance - 2 Toxicologist 3hrs/wk x 78 wksx $40/hr Development - 240 hrs x $40/hr x 2 Toxicologist $18,720 19,200 Non-Technical 3 Lab Asst. 3x8 hrs/day x 376 days x $10/hr ] Technical 1 Technican/study 2x8 hrs/day x 376 days x.$10/hr Supervision Research Toxicologist - 5 hrs/wk x 78 wks x $60/hr x 2 studies Section Chief - 2 hrs/wk x 78 wks x $60/ hr x 2 studies $46,800 18,720 Statistics $5,000/study x 2 studies Biochemistry $14,000/study x 2 studies Pathology 840 rats/study x 2 studies x $150/rat 720 T1O2 rats x $20/rat (special stains) $252,000 14,400 Miscellaneous Disposable clothing, and Reports . TOTAL FOR AN 18-MONTH EXPOSURE AND 6-M0NTH HOLD $ 90,930 37,920 90,240 60,160 65,520 10,000 28,000 266,400 18,000 $667,170 2- - ADDENDUM Cost Estimate for Additional 6 Months Exposure (Not Included in MR proposal cost) Toxicologist Continuance -2x3 hrs/wk x 26 wks x $40/hr Technican Continuance -2x8 hrs/day x 126 days x $10/hr Lab Assistants 3x8 hrs/day x 126 days x $10/hr Supervision Research Toxicologist - 5 hrs/wk x 26 wks x $60/hr x 2 studies Section Chief - 2 hrs/wk x 26 wks x $60/hr x 2 studies $15,600 6,240 $ 6,240 20,160 30,240 21,840 SUBTOTAL $ 78,480 TOTAL FOR A 24-MONTH STUDY $745,650 *This protocol is not the final one. Many items were explained only in general terms and will be detailed at a later date (pending completion of fourweek preliminary studies, etc.) A final protocol will be issued at that time. DUP050447989