Document x5GJr6ZGxp89Z974EaZNQJjgb

- o. spf 3M LBarryRR. JoPhp.nBsonr CSoWrpSoiractcenTeDneipcaorotgmyent 2EHR _ 0202-00373 beCHOh -20 -23)3 February 8, 2002 3RMICaEnter, Buin 0220-02.02 So733020 OMe ey 7oe vo DD ocumentF Processing Cenntenr (s7e4n07iMo)rs) OfficeofPollution Prevention and Toxics U12S00EPPAennsylvania Ave, NW Washingion, DC 20460-0001 TR 226= 1070 so 3 2 2 CERTIFIED MAIL : T(CSACSAR8N(E2)7S95U-P39P-L3)EMDEocNkTeAtLReIf:NF-0O3R7M4ATION: potassium perfluorooctanesulfonate Dear Sir Contzr 7 CBI Tz 2 3foMr piostsausbsmiiutmtipnegrftlhueofrionoacltraenpcosrutlffornoamteCo(vCaAnScReNLa2b7o9r5a-t3o9r-i3e)s,oonritghiena2l-lyyenaortriaftiefdeetodiEngPAstiudnya 2 JpeetrtfeludoartoeodctMaancysu2l4f,o2n0a0t1e. inIbnioaldodgiitcioanl,stahmeprleepsoratssooncicahteemdiwciatlhatnhaelysstiusdfyoirs included with this submission npetrhfelusotruoodcytianncelsuudlefdonwaitteh(sPuFbOmSi,ss8i6o.n7,%S)priangtuheeDdaiewtlaety0,ra0ts5,we2r,e5,gi&ve2n0ppoptamssfiourmup to 104 Wteeerkmsi.natOionnewgirtohuoputrefcuertihveerdt2r0eaptmpemnti.n tIhnetedriiemt sfaocrri5f2icweeseokcscuarnrdedwaatswaelelkoswe4d, t1o4parnogdr5e3ssftoor hTiSstCoApaStheosluogbym,iscselilonprdoilsifceursasteidonpraenldimpienrafrlyuoorbosoecrtvaanteisounlsforneagtaerddientegrtmuinmaotrioinn.ciTdehnecep.rior TSihgrnoifuigchanttelrymd,escurrevaisveadl fwoarsfseimganliefsicaatnt5lyanidnc2r0eapspemd.forAbmsaolleusteanadndbordeylawtievieghlitvserwwereeighs in aprleesesntanatdmrienlaitmiavelldiovesresweoigf2htpspimn finemmaalleesswaenrde5inpcpremasiendfaetma2l0esp.pmH.epaLtiovleorxtiocxiitcyitwyawsasnot _ Dardeesneontmianw2a0spipncmreraesecdo.verHyepaantiomcaellsl.ulFaorramdaelneosmian wthaes2n0otpopbmsedrovseedgirnoutphe, 2he0paptpomcerlleucloavrery = <> eroup males. Thyroid folicular cel adenoma was increased for the 20 ppm recovery group == `dmoasleesg,ryoeutp,thheerpeawtoecreellnuolaorthaedreinnodmicaatwiaosnsoinfcrteahsyerdo.id Iatbsnohromuallditbye.noFtoerd ftehamtaltehse ipnritohre 20 ppm " otification had ppm dose level. iTnhdiiscaftienddainngidnicdrenaoste rienmpaainncraefatteirca ipslaetthcoellolgcyarpeceirnormeaviienwmwaalsescoatndtuhcete2d0. hii Irnepaodrdtitoinonc,y3noMmoilsgsuusbmmiottniknegyaocnoppyootfastshieumfipnaelrfrleupoorrotocotrantchseu2lf6o-nwaetee.k cAapdsrualfet rteopxoicrittwyasstudy Speurbfmliutotreodoc0taEnePsAulafsonaante8(icn)bAiuoglougsitca2l1,sa2m0p0l0e.s Aassroecpioartteodnwcihtehmtihcealstaundaylyissiaslsfoorincluded with ths submission. ' 0008318410 Groupsofmale and female cynomolgus morikeys were given oral capsules containing doses `epqoutiavsaslieunmt ftoor0,1802.0d3a,ys0..1R5,ecoorv0e.r7y5 amngi/mkagl/sdfaryopmotthaesscionutmropler0f.l1u5oraonodct0a.n7e5sumlgf/oknagt/edaays the ttrheea0t.m7e5ntmgg/rkogup/sdawyedroesmaogneitioncrleuddefdorcoonmepoyuenadr-arfetlerattreedatmmoerntta.litSyiginnitfiwcoanotfsaidxvemrasleeefmfoenctkseyats, edsetcrraedaisoledlebvoeldsy, wheeipgahttosc,elilnuclraerahseydpelritvreropwheyigahntds,lilpoidwevraecduosleatriuomn.totNalocpheolreosxtiesroolm,alloowrecreeldl proliferation was detected. Complete reversal of clinical and hepatic effects occurred within 2P1O1Sd.aysLipvoesrt--ttor-esaetrmuemntPaFnOdSwarastiaocscwoemrpeancioemdpabryabsligeniifnicalalntdodseecrgeraosuepss,inwistehruamraanndgeliovfer 1 0no2:a1d,verSseereuffmecctosncweenrteraptrieosnesnti)nwtehree0.125.6mg+/2k5.g2/dapypdmosfoergmraoluepsaatntdhe66.n8 do+f1d0.o8 sipnpgm(wfhoerre females. For further information on this study contact Dr. John Butenhoff, 651-733-1962. Sipesely, Harv \ yy nea LDiarrercytoR.r,JCoohrnpsoornate Toxicology Enclosures 2 Reports Submitted with letter of February 8, 2002: FiPnearflluRoerpooarctt,an1e04Su-lWfeoenkicDAiectiadryPoCtharsosniiucmTSoaxlitc(iPtyFOaSn;d TCa-r6c2i9n5o)geinniRcaittsy (SCtouvdaynwciethStudy No. 6329-183), 3M Reference No. T-6295, January 2, 2002. + APnearlfyltuiocraolocLtaabnoersautlofronyaRteepo(rPtF,ODSe)teinrmLiinvaetriaonnodfStehreumPrSepseencciemeannsd oCfonCcreln:tCrDa(tiSoDn)oIfGS BR REantvsirEoxnpmoesnetdaltoLaPbeorrfaltuoorryooRcetpaonretSuNlof.onTiOcX-A0ci0d2,PoLtaabsosriautmorSyalRte(qPueFsOtSNTo-.62U9251)2,13, M3M Ref. No. T-6295.4, February 21, 2001 FiPnoatalssRiepuomrtSa,lt26(-PWFeOcSk: Capsule T-6295) Toxicity Study in Cynomolgus wMiothnkPeeyrfslu(oCrooovcatnacnee Sulfonic Study No. Acid 6329 223), 3M Reference No. T-6295.7, January 11,2002. AnialtyhtiPecraflluLoarbooorcattaonreySRuelpfoornti,c SAecpitdePmobtearss19i,um20S0a0lt, ("T2-66-2W9e5)ckinCaCpysnuolmeolTogxuisciMtoynSkteuydsy, LDievteerrmainndatSieornuofmtShaempPlreess,e"ncteo aancdcoCmopnacnenytrCaotviaonncoefLPaebrofrlautoorroioecstaInnee.s,uSlftoundaytNeo(.PF6O32S9)-in 223, 3M Medical Department Study No. T-6295.7, Report No. FACT TOX-030