Document x5EBZgKBb6Ydj04VBVZdE1rGE

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1952 Jan-May DOC#: API027 DOCUMENT DESCRIPTION: Letters, Memos, Reports, Financial Reports & Other Relevant Documents from Jan-May, 1952 January 9, 19^2 To M e m b e r s of the Sub-Committee on Carcinogenicity: On D e c e m b e r 10, 1951 a c o p y of the minu t e s of the neeting of the R.P.A. Committee, which was held at Kettering Laboratory November 26, 1951 was sent to you along with a letter ballot asking for your vote with respect to the action taken at the C i n c innati meeting. The m i n u t e s reflect the m u tual a g r e e m e n t of the K e t t e r i n g L a b o r a t o r y and the R.P.A. Cormrittee with respect to the immediate objectives of the R e s e a r c h P r o j e c t on C a r c i n o g e n i c i t y . T o d a t e f o u r t e e n ballots, all in the affirmative, hav e b e e n returned f r o m the twenty-five members of the sub-committee. In order that we m ay advise Dr. Kehoe that the ac tion taken has the approval of the Sub-Committee on Car c i n o genicity, I would greatly appreciate it if those whose names are s h o w n b e l o w w i l l r e t u r n t h e i r b a l l o t s to m e at the earliest date possible. A letter ballot is again attached for your convenience. Very truly yours, 1 Doctors: L.E. Curtis, T.M. Frank, W.R. Levis, James W. Long, Clark R. Miller, James W. Osborn Messrs: R.M. Shepardson, L.O. Crockett, R.M. Landon, C.R. Brown, F.J. Sanders cc Dr. E. K. L i n d e r Mr. D. V. S t r o o p API 05208 A merican P etroleum Institute SO W EST SOtm STR EET NEW YORK 2 0 . N. Y. January 10, 1952 To Members and Associates Subcommittee on Carcinogenicity Gentlemen: On December 10, 1951, a copy of the minutes of the meeting of the B.P.A. Committee, which was held at Kettering Laboratory, November 26, 1951, was sent to you along with a letter ballot asking for your vote with respect to the action taken at the Cincinnati meeting. The minutes reflect the mutual agreement of the Kettering Laboratory and the B.P.A. Committee with respect to the immediate objectives of the Besearch Project on Carcinogenicity. To date fourteen ballots, all in the affirmative, have been returned from the twenty-five members of the subcommittee. In order that ve may advise Doctor Kehoe that the action taken has the approval of the Subcommittee on Carcinogenicity, I would greatly appreciate it if those whose names are shown below will return their ballots to me at the earliest date possible. A letter ballot is again attached for your convenience. Very truly yours Enclosure Doctors: Messrs; sc: Dr. Mr. L. E. T. M. V. B. James Clark James C. B. L. 0. B. M. F. J. B. M. E. K. D. V. Curtis Frank Levis V. Long B. Miller V. Osborn Brown Crockett Land on Sanders Shepardson Linder Stroop Chairman, Subcormittee on Carcinogenicity API 05209 LETTER BALLOT of the Subcommittee on Carcinogenicity Medical Advisory Committee American Petroleum Institute PLEASE MARK AND RETURN TO: Dr. M. N.Newquist, Chairman Subcommittee on Carcinogenicity c/o The Texas Company 135 East i*2nd Street New York 17, New York i Shall the actions and decisions of the Research Project Advisory Committee, as shown in the minutes of the November 26, 1951 meeting at Kettering Laboratory, Cincinnati, Ohio, be approved by the Subcommittee: Yes ___ No* Not voting i (* It is requested that any negative vote be accompanied by an explanation.) NAME COMPANY DATE API 05210 January 9 1952 Dr. R. A. Kahoa Kettering Laboratory unlweraity of Cincinnati Bdan Avenue Cincinnati ( Ohio Daar Doctor Xchoct It waa the ooaaanaua then we act with you on lovnbtr 26. that there abould be another mating of the It.P.A. Comlttee with your group prior to the neeting of the Medloal Advlaory Comlttee of the A.P.I. in April. antion waa node of holding the meting the last of February or the let of larch. Z m wondering boo February 26th or larch itth would fit In with your plane for a nee ting at Kettering laboratory. laterally eo would like to clear with you aa to datee before eendlng out feelera to the comlttee aeabera aa to preference. There la no queetlon but that a one-day aeetlng would auffloe. cry truly youra. 31 37. 377T7QU:ST, M.D IiTf:DICAL E1SZCT0E I. V. 1BVQUIST. I. D. nniRit API 05211 A merican P etroleum Institute 5 0 W EST 50TH STR EET NEW YORK 2 0 . N. Y. January 10, 1952 To Members and Associates Subcommittee on Carcinogenicity Gentlemen: On December 10,.1951, a copy of the minutes of the meeting of the R.P.A. Comalttee, which was held at Kettering Laboratory, November 26, 1951, vas sent to you along with a letter ballot asking for your vote with respect to the action taken at the Cincinnati meeting. The minutes reflect the mutual agreement of the Bettering Laboratory and the HJ.A,. Conmittee with respect to the ismediate objectives of the Research Project on Carcinogenicity. To date fourteen ballots, all in the affirmative, have been returned from the twenty-five members of the subcommittee. In order that we may advise Doctor Behoe that the action taken has the approval of the Subcommittee on Carcinogenicity, I would greatly appreciate it if those whose names are shown below will return their ballots to me at the earliest date possible. A letter ballot is again attached for your convenience. Very truly yours, Enclosure Doctors:. L. E. Curtis T. M. Frank W. R. Levis James V. Long Clark R. Miller James W. Osborn Messrs r. C. R. Brown L.. 0. Crockett R. M. Landon F. J. Sanders R. M. Shepardeon me: Dr. E- K. Linder Mr.. D. V. Stroop M. N. Newquist, M.D. Chairman, Subcosmittee on Carcinogenicity ApI 05212 LETTER BALLOT of the Subcommittee on Carcinogenicity Medical Advisory Committee American Petroleum Institute PLEASE MARK AND RETURN TO: Dr. M. N. Newquist, Chairman Subcommittee on Carcinogenicity c/o The Texas Company 135 East U2nd Street New York IT, New York Shall the actions and decisions of the Research Project Advisory Committee, as shown in the minutes cf the November 26, 1951 meeting at Kettering Laboratory, Cincinnati, Ohio, be approved by the Subcommittee: Yes NO* Not voting (* It is requested that any negative vote be accompanied by an explanation.) NAME COMPANY DATE API 05213 January 14, 1952 pr, M. V* levqulst Tb* TexasCmpany 135 saat 4aid Street lv York City 17 ptr Doctor levqulst1 X know of no reason for not baring tbs nesting of tbs R.P.A. Colttee on February 26 or thereabouts. Harsh 4 finds ne n t h an engagssiant out of tom. This need not deter you fron nesting here an tbs latter date# sines Drs. Hsyroth# Horton and pmir rill be arallable. Hoveeer# If yon mat ne available# I'd appreolate your seleotlng tbs 26th. With kindest regards # Sincerely yours# R1K e f C.C.* Mr. D. V. Stroop Dr* XJC. Under API 05214 _ f * Porter Iff ' Re: API M edical A dvisory C o m ltto o Pursuant to plane d iscu sse d w ith you r e c e n t 17, Mr. 3urm tnd I c n fe rre d in f e r n a lly w ith H V F ie ld , S K. L in d er, V F Stroud 1^4 It D Bent an Monday, January 21 a t , in P h ila d o lc h ia . V* reviewed the almatee f the itoviibtr 6 matins of the antral oenlttee, Division of fteflning, which records a unanimous y0te in favor of a resolution - "That the Chalman of th# deneral Comlttoe of the Division of Soflnln* appoint a eubcawwlttee canvowed of mnbere of amid Oeneral Comlttaa to review tho :aat work of said Nodical Advisory Comlttoa aa it ^ortaisa to finished and unfinished -etroleun roducts, and to rofinery operations aa ail aa to review work now under way and urogram, if any. for future work- in this field, and to reeaswond to tha Owners1 Comlttee awch ater-a aa it feels should bo taken, together with such mechanise as it fee's should be established to secure the beet poesl ble results from the standpoint of the ew-rloyeee of the petroleum Industry and the users of petreltun vrodoeta No also considered a stateswnt in the sane nlnutes that ~ 'thera was unanlmoa agreswept that tha Tice President for Refining should confer with the Chairman of the SeTety Ceanltteo of the Board to dotemine whether or net e mchanlsa eaa be worked out whereby tha Nodical Advisory Cemlttoo eaa bo furnished direct assistance and advice of seal iflad refiners ' Our discussion led to e consensus that the working out of *** mechanism sought by the General Cowalttee would be facilitated **d expedited by oint conference and collaboration of two snail sub- lttees representing the -lenerel Cownltteo and the Medical Advisory API 05215 - 2- litt A ccordin gly, lt mts iufgMU4 that John R. S o u . Choi Conaitteo of tho Board, should lnfora 9r Linder regarding the ,f7 Cansittee action, and suggest that Dr Liador taadar to , steesrt, Tr . Chairaaa. Oanoral CoaBlttes, tho esrelces of a 1 .git,] sube nanl t too o f n o d ic a l e o o n ltto o nonboro ho eould a a a la t ^ ^ fin e r y a u b e o n ltto o la l t a r o d o o f tho r>ast, proaoat aad fa turo die! rosearen nogre* and ln tho verklag out of a aechanLbs to 1 gttfUf tho resulta described In tho nceolutioa In ay understanding that yea plan to dloouaa this aattor fltti Nr Sonar, I have seat hla a copy af thla aaaoimndun and a copy gt tho attaehod rough draft of poaalbla lottar to Dr. Lindar. DTSrrd itt . D V Streep it - John H V V ? Z r R D V T ~ Siniii, Chalxouui, Safety Connlttoe of tho Board of Directors field, Tho Atlantic Bofining Coepaay Stroud. Nanbor Donor1 Comities, Division of 30fining Liador N B . Chalroan, API Nodlesl Advisory Comit tee Bent, Associate Meeber, AFX Nodical Advisory Cemlttee Ouan, Director, APS Division of Noflnlng 05216 January 24, 1952 RPA COMMITTEE SUBCOMMITTEE ON GARCINOGSNICITY M E D I C A L A D V I S O R Y C O M M I T T E E - A.F. I. pr, R. A, K e h o e Kettering Laboratory 3den and B e thesda A venues Cincinnati, Ohio pear Doctor Kehoe: Fo r your information I am enclosing two copies of the minutes of the m e e t i n g attended on N o v e m b e r 26, 1951 by the Research Project Advisory Committee and Dr, Kehoe and associates of the K e t t e r i n g L a b o r a t o r y r e l a t i v e to r e s e a r c h on c a r c i n o g e n i c i t y sponsored by the A.P.I. The m i n u t e s h a v e b e e n s u b m i t t e d to all m e m b e r s and associates of the Medical Advi s o r y Committee of the A.P.I.- Letter b a l lots hf.ve b e e n r e t u r n e d f r o m 24 of the 25 m e m b e r s and a s s o c i a t e s of the S u b c o m m i t t e e on C a r c i n o g e n i c i t y and t h e b a l l o t s s how u n a n i mous approval of the action expressed in the minutes. No doubt you have already effeotuated procedures to attain the objectives as discussed at the m e etinr and expressed m said minutes. F o r information of the members of the Subcommittee on Carcinogenicity I will be pleased to reoeive your outline of f u n d a mental f a c t o r s c o n s i d e r e d to be s i g n i ficant to the e s t a b l i s h m e n t of s t a n d a r d i z e d p r o c e d u r e s as m e n t i o n e d u n d e r R e f e r e n c e S t a n d a r d s on Pa~e 2 of the m i nutes. Yours very truly LIN!::GK Copies to Subcommittee Members and Associates Dr. E. K. Lind e r Mr. D. V. S t r o o p M.N.Nowquist, M.D., Chairman Subcommittee on Carcinogenicity Api 05217 A merican P etroleum Institute BO W EST BOTH STR EET NEW YORK 2 0 . N. Y. o f TECHNICAL s e r v ic e ^,rvft'Tw btroor. directoii revio v 135 East 42nd Street New York 17, N. Y. February 1, 1952 To Members Research Project Advisory Committee E. W. Adams C. H. Eine, M.D. L. C. Beard, Jr. R. M. Landon Kieffer Davis, M.D. E. K. Linder, M.D. Robert E. Eckardt, M.D. K. G. Mackenzie T. M. Frank, M.D: R. C. Mithoff R . M. Shepardson Gentlemen: A meeting of the Research Project Advisory Committee of the Subcommittee on Carcinogenicity will be held on Tuesday, February 26th, at the Kettering Laboratory, Cincinnati, commencing at 9:30 A.M. It is hoped that the business at hand may be completed by 4:00 P.M. I will circularize Doctor Kehoe's statement on "fundamental objectives and factors pertinent to standardized methodology" as soon as it is received. In the interim you have no doubt given thought to the continuing study on carcinogenicity and I would greatly appreciate hearing from you as to any items that you feel would be helpful to the research project and which should be considered. I will then list such items on our agenda to supplement those which will be presented by Doctors Kehoe, Horton and Phair. I would like to have such an agenda in the hands of the committee members prior to the meeting on February 26th, so your prompt response will be appreciated. Those staying overnight in Cincinnati should make their own hotel reservations. Very truly yours, MNN:RMS me: Dr. Robert A. Kehoe Mr. D. V. Stroop Project Advisory Committee API 05218 g^jipUM FROM DR. M. N. NEWQUIST YORK, N. Y -- J a n u a r y 31. 1 9 5 2 n. y. s t r o o p _____________ ---------------------------------------------- i;iH you also send a copy pr< George M. S a u n d e r s , who be an alternate for L. C. 135 East ^2nd Street N e w Y o r k 1?, N. Y. January 31 1952 embers of the R e s e a r c h P r o j e c t Advisory Committee A m e eting of the R e s e a r c h Project the S u b c o m m i t t e e on C a r c i n o g e n i c i t y w i l l be February 2 6 th, at the K e t t e r i n g L a b o r a t o r y , at 9 3 0 A.M. I t i s h o p e d that the b u s i n e s s pleted b y i+:00 P.M. Advisory Committee of held on Tuesday, Cincinnati, commencing at hand may be com I will circularize Dr. Kehoe's statement on "fundamental objectives and factors pertinent to standardized methodology" as soon as It I s recei v e d . I n the i n t e r i m y o u have n o d o u b t g i v e n thought to the c o n t i n u i n g s t u d y on c a r c i n o g e n i c i t y a n d I w o u l d greatly a p p r e c i a t e h e a r i n g f r o m y o u as to a n y i t e m s t h a t y o u f e e l would be h e l p f u l to the r e s e a r c h p r o j e c t and w h i c h s h o u l d be c o n sidered. I will then list such items on our agenda to supplement thosi w h i c h w i l l be p r e s e n t e d b y D r s . K e h o e , H o r t o n a n d Pha l r . I would like to h a v e such an a g e n d a in the h a n d s of the c o m m i t t e e members p rior to the m e e t i n g on F e b r u a r y 2 6 th, so your prompt r e sponse will be appreciated. Those staying overnight in Cincinnati should make their own h o t e l r e s e r v a t i o n s . Very truly yours, M. N. N E W U I S T , M. D. Chairman, Subcommittee on Carcinogenicity MNN:RMS E. W. A d a m s L. C. Bea r d, Jr. Kleffer Davis, M. D. - A-tK. ->*'_ R. E. g c k a r d t , M. D. T. M. F r a n k , M. D . -- C. H. H i n e , M. D . -- An Z * * 1* 1 *- A-UZ. ^*-1-- R. M. L o n d o n E. K. L i n d e r , M. D. R. G. M a c k e n z i e R. C. M i t h o f f R. M. S h e p a r d s o n /vuz m u . D. V. S t r o o p - for i n f o r m a t i o n R A . Kehoe , M . D . API 05220 Copy from M. R. Revquist, M.D., for Information of Members of the Research Project Advisory Committee and Member and Associates of the Subcosmittee on Carcinogenicity. ____________________________________________________________ 2-4-52 January 30, 1952 Dr. M. If. Revquist Medical Director The Texas Company 135 East 42nd Street Rev York 17, Rev York Dear Doctor Revqulst: Attached is the promised outline of basic studies vhich are under vay to standardise the mouse testa. This is, in effect, an acceleration of the work on that phase of the over-all program, which vas designated as section B, "Reference Standards," In our memorandum of Rovember 26, 1951 and the minutes of the first meeting of the Project Advisory Cosmlttee. Since we are a few days past the date on which we had intended to have this outline in your hands, Dr. Kehoe has asked me to send it m i to you, although his departure from Cincinnati Monday evening necessitated postponement of any detailed editing of the material on his part. Sincerely yours, AWH:mJg CC: Dr. . K. Linder Mr. D. V. Stroop A. Wesley Horton API 05221 STANDARDIZATION OF BIOLOGICAL TESTING METHODS API RESEARCH PROJECT MS-1 I, Reproducibility of Results of Mouse Tests A. Effects of variations In health of animals 1. Toxic effects of materials under test a. Systemic poisoning b. Irritating and lethal effects on epithelial cells c . Relationships betveen dosage and latent period for Induction of tumors 2. Effects of intercurrent infections 3. Development of criteria for assaying the degree of validity of results of any given mouse test B. Application of statistical methods to establish confidence limits II. Influences of Non-carcinogenic Components of Petroleum Products on Their Effective Potencies A. Inhibitory properties 1. "Viscosity effects," influencing the potencies of tars, vaxes, and cokes 2. Effects of specific classes of materials, such as benzanthracene derivatives, trace metals (reduced crudes), catalyst fines, etc. B. Specific irritant properties which reduce the latent period for induction of tumors C. Improvement of analytical techniques for estimating potency, resulting from correction factors based on these fundamental catalytic and inhibitory properties This outline defines certain factors to which consideration will be given in an effort to standardize biological testing methods for determination of relative carcinogenic potencies of petroleum products. API 05222 Frrusry 13 , 1952 Lr. N. K. Irvqulst, Cbalrma MAC Suteomdttse on Csrclnc#ralrltj e/oIteUh m Caspsay 13$ Xut tni Street Sa* Teorie 17# tev York Dm p Doctor B--quio te Fo t joar iafamstioa and for possiti* eansldarstlaa ty tte SPA C o M d t t M ss soli ss tte StitecoelttM an Cure 1impanicity, tter* ls snirloMd a copy of aalf-arplanstory lottar, datad Tbrvarj 11, 1952, fresi Doctor tetes, vitti aa estteatsd tadpst far tte ysor sadlng Jims 30, 1953* tery truly yours, DISto Saelosurs API 05223 la* * * t0* t UNIVERSITY OF CINCINNATI m w uTB iM T or M u v o m v K uicim a id i n w m u u a l t h February 11, 1952 C U L I ADOUSSt KSTUUI. CINCINNATI T SL IM O aii CAPITOL MU Ygjerican P e t r o l e u m I n s t i t u t e en Vest 5 0 t h S t r e e t jjev Y o r k C i t y 20 Dear Mr. Strcop: X send y o u h e r e w i t h the e s t i m a t e d budget, for the y e a r b e g i n n i n g July 1 1952. It is b a s e d on c e r t a i n c o n j e c t u r e s , of c o u r s e , ~ fcut if the w o r k c o n t i n u e s as e a n t i c i p a t e that it w i l l a n d probably should, this is a fairly realistic estimate. The status of the f u n d s at the e n d of y o u r 1952) can be estimated with fair precision for the c a l e n d a r y e a r 1 951 are f i n a l i z e d . near future, at w h i c h time you and we wil l the s i t u a t i o n . fiscal yea r (July 1, as soon as our accounts This will come in the be able to visualize I trust that this information will be satisfactory for present purposes. nw o r d i a l l y y o u r s Dictated but not read Enc. API 05224 B jD G Z T D A T A F O B AMERICA?; P Z T R C L Z J M I Z S T I T T T E Tn v e s t l g a t i o n of C u t a n e o u s C a r c i n o g e n i c M a t e r i a l s b; The Kettering Laporator" Estimated budget froc July 1 , 195P to July 1 , 1953 compensation for Personnel (itemized below) t"4p ,cGC _/u Supervision - general nemical Technology and Epidemiology (Direct Salaries itemized below) Principal investigators Experimental and Technologic Epidemiologic Surveys Research Chemists 8 ,000.00 5 , 0 0 1, on 1 2 ,500.00 Biological Testing (Direct salaries itemized below) Gross pathology and animal records - Microscopic pathology Technicians (testing) Total Compensation as Direct Salaries 2 ,6 0 0 .0 0 C J Jvj 3 , 7 0 0 00 3 8 ,800.0 0 Indirect Salaries (itemized below) Initial postmortem examination Preparation of microscopic slides 1 ,200.00 3,600.00 Other Expense Supplies (indicated below) Supplies miologic Supplies for Technologic and Epide work for Biological Testing 3 ,5 0 0 . 0 0 3,500.00 Travel Animals Overhead - all other items including indirect salaries that cannot be itemized, pensions and annuities, educational expense, heat, light, power, secretarial service, library service, janitor service, general maintenance, etc. f %J -J J\ 8 ,3 OO 0 : 4,800.00 7 O 0 ` 5 ,000.00 2 ,6 0 j .00 4^,500.00 Total Estimated Budget for all purposes $104,760.00 API 05225 A merican P etroleum Institute 5 0 W EST SOTM STR EET NEW YORK 2 0 . N. Y. February 15, 1952 jo M embers Special Coordinating Camnlttee Kleffer Davis, M.D. - Phillips Petroleum Co. Kenneth R. Fourcher, M.D. - Standard Oil Co. (New Jersey) James V. Long, M.D. - Gulf Oil Corp. M. N. Newquist, M.D. - The Texas Co. B. B. Reeve, M.D. - Standard Cll Co. (Indiana) Gentlemen: Mr. Stewart has accepted the suggestion made in my letter of February 1, 1952, and I have made arrangements for a meeting of the liaison subcommittees to be held on WEDNESDAY_______FEBRUARY 27. 1952_______ AT 10:00 A.M. in the Netherland Plaza Hotel, Cincinnati, Ohio. So that you may be fully informed on the status of the Kettering research project, Doctor M. N. Nevquist, Chairman, Research Project Advisory Committee, invites you to attend the RPA Comnlttee meeting to be held at the Fettering Laboratory, University of Cincinnati, at 10:00 A.M., on Tuesday, February 26. By copy of this letter we are also inviting the members of the Refining Liaison Subcommittee to attend the RPA Committee meeting on February 26. E. K. Linder, M.D. Chairman oc: Messrs. W. T. Gunn Medical Advisory Committee F. M. Porter W. L. Stewart, Jr. D . V. Stroop John R. finTMw . me: Members, Refining Liaison Subcommittee Messrs, w. R. Argyle - Sinclair Refining Co. M. Halpern - The Texas Co. William Naden - Esso Standard Oil Co. Harold G. Osborn - Continental Oil Co. Max G. Paulus - Standard Oil Co. (Indiana) C. S. Teitsvorth - Socony-Vacuum Oil Co., Inc. API teat Mr. Liter right 05226 A m e r i c a n p e t r o l e u m In s t i t u t e SO W EST BOTH STREET NEW YORK 2 0 . N. Y. February 15, 1952 MEMORANDUM TO: Messrs. W. R. Argyle M. l a l p e m . William Naden Harold G. Osborn Max G. Paulus C. S. Teitsvorth Gentlemen: Doctor Linder has asked me to send you the enclosed information, as follows: 1. List of members and associates of the Medical Advisory Conanittee. 2. Outline of Objectives, Functions and Procedures of the Medical Advisory Committee. . 3. Minutes of the RPA Committee meeting held November 26, 1951* Mr. Wilbur Wright, Reservations Manager, Netherland Plaza Hotel, Cincinnati, is holding single guest rooms available for your use. Please notify him as to the date and time of your arrival. Very truly yours, 3DVS:c Enclosures m e : Mr. W Dr. E Dr. M T. Gunn K. Linder N. Nevquist API 05227 T S tandard O il C ompany I m u iA) 910 S o u t h M ic h ig a n Av e n u e C h i c a g o 8 0 , Tt .t . February 13, 1952 Mr* D. V. Stroop, Director Department of Technical Services American Petroleum Institute 50 Vest 50th Street New York 20, N. Y. Dear Mr. Stroop: I received my appointment as a member of the Special Coordinating Committee of the Medical Advisory Committee. In his letter of February 1, Dr. Linder suggested that a meeting of this committee be held on February 27 in Cincinnati. To date I have had no notice of any set time for this meeting. Has any decision been made as to the date? Please let me know so that I can make plans accordingly. I was in Texas last week and had a very nice visit with Dr. Frank of Pan Am and Dr. Baird of the Humble Oil Company. Dr. Frank will probably discuss some of the things ve talked about if he sees you in Cincinnati at the meeting on February 26. Yours very truly, S. S. M>D Medical Director BBR:S API 05228 T b r v m r j fc, 1992 Te M-- bara of Spcial Coordinatine Ccanlttaa Xlaffar Darla, M.D. Xennath R. 'ourchar, Je-- a V. Loa, M.D. M. I. -- quiet, M.D. B. B. Rn n , M.D. M.D. Geatla-- ns A* atated la th anelo-- A cojy of lattar datad Fefcr-- ry 1 to V, L. Sta-- rt# Jr., D oe t c r Lindar, Chair-- a, Ntdleal Adrlaory Ccaaaltt-- , has appolated 70a to aarre aa a 3p edal Coordinatine Ce-- ttee to collabarata vith a apeo lai subccaadtt-- of the Os-- ral Co-- ittee, Dlrlaion of Reflnlng, la the vorklag ont cf tbe -- ebani-- referrad to la the attacbed lattar datad Jeauary 29 Trcm Jibn R. S-- an. Doctor lindar 111 serre ex officio aa Chair-- a X the Special Coordinatine Cc-- lttee. Yery tralj youra, DYB:c Enc Ioaurea ec: Dr. X. X. Lindar API 05229 THE ATLANTIC R EFIN IN G C O M PA N Y PETROLEUM PRODUCTS se n south broad street P H IL A D E L P H IA 1. PA . relations department ,,lA- M n DIRECTOR MEDICAL DIVISION bruary 1, 195D Mr. D. V. Stroop American Petroleum Institute 50 West 50th Street New York 20, N. Y. 7 Dear Mr. Stroop: As per my telephone discussion, I am enclosing copy of letter to Mr. Stewart, trusting you have a copy of Mr. Suman's letter to me, in order that you may take the necessaiy steps to advise this newly appointed Special Coordi nating Committee of this action and of their appointment. Dr. Fourcher has indicated that he desires to be a member of the committee with the understanding that he may be able to appoint a designee. Very truly yours, uKL:mb El LINDER, M. D. API 05230 filruix 1 1952 )tr. V. L. Stewrrt, Jr. Unirti Oli Coapengr of California 17 Vaat Seventh Street Lo* Angele# 17, California p*<ir Xr. Stavarti la aeeord vith Hr. S w a s 'a lattar ta se, datad issarr 25, 1952, it la Sf daaira lo expedita asp aetioa oc tlM part of th Madlaal Advlaojy Coosittee vhieh vili aid th (tonerei Censittao, Dirialo of fteflnlng, work out th noohanlas referred ta la thair reeolntioc aa qsoted. I a ippoiating a asheaeatlttee eospoeed of ala oaobara of tha Madlaal <dTaei7 Coaolttao, vhieh aoheoeadttoa vili ho preparad to eoli*borato vitto s aubeocaittee of tha donarmi Cencittae, Divisin of Beflning. Thene llelaon asbeoanlttaaa, I *o cartai, ama dlacuas iad prenota a batter automi under*tending. Lavadla t-ely follaving tha Sovesber aaeting of tha Medicai dvioory Cosrsittee a Reaeerch Project i&rlMcrry Sabooanittaa v*a r.ppoiated far th axpraoa psrpoee of salutainiag a olaaer contaet vlth Dr. Kahoa and -aaoci^taa of tha lettering leboretoiy relativa te thair reeeareh aa eareiDOgenlelty oponaorad bgr tha Asazlean Petrleos Inatitarta. A accl ine of thia subeoaaittee asd Dr. Kahoa and aaaooiatee vao hsld os Bevasi bar 26 and aaother aeetlng la pltnnad for Patonarjr 26. It la sy pareonal opinion th.it tha Bovasbar aeetlng preved af valsa both to Dr. Kahoa and hit -seoeiateo and aleo to tha Ssbaossittaa on Carolaogealclty. Thla paat aaeting, aad futura saatlngf, X as aura, vili eerve tfaolr psrpoaa to .rorida a cloaar band of undortandlag and eoliaboratlos la diraetlon af voz* aa as ta aeeenpliah tha ohjeetivoo ls tha loaat poaalbla tina m d a t tha loaat poooiblo oost. Zaaasoeh ao thara vili ba avallable gp-ta-dato inforsatlon oa tha raaaareh as carelnogonldty at tbo Kattarlng Laheratory Isaodlatoly fol*> lavine tha aaeting af Pebrsazy 26, oay 1 taha tha Liberty af osggaetlng that tha lialaoo asboawslttaao oaat on M m i y 27 in CinolnBatl? flbeoid thla not ba agraoabla, or heid it ba ls eonfllat vlth previooa API 05231 -2- v# U Stonarti Jr. * ' Fafcnasy 1, 1952 va vili OtfWt. suita villini to m i ai aagr attor tioa er plaaa t* e e e ltte a , vhib va ah*11 rafar te as tfea Spealal C eertlnatlaf e f th Radicai Adrleary C i - l t t H , i l i to eoNpaead a f it o fallici* " terit U r i , K* S, Phillipa PetsolMi flw y w y krtltnillcf (klitot lanaatfe & Pauretor, IL B. ' Standard OH Coopaqr (tev Jarvejr) 30 Baakafaliar Plana tov Iark 20, I. I. ' X. U n Liader, X. L ; u m V. m l X. B. 0 lf O li C a rp a n ti Frt lrtto r , T a u R. I . I w i d i i , IL B* Tto t a l i C p u p 135 B i i t o I t r w t l w lode 17, ! ! B. B. t o r i , X. 0 . Standard O li Caapeagr (ladiaaa) 910 Swtb K ia h ifu t o n i CbieaflB 80, IIlinai* Vtrjr truly yaars, BLtik NI Mr* V. T. Ooaa Mr. F. K. Partar Mr. J . B. Som* t Dr. K iaffar Brti* Dr. L L t o n t o Dr. J . V. Leo* Dr. IL 1 , t o q d .i t Br B* B* Beava bc: Mr. D. V. Stroop S* I m Lladar, R B. API Radicai Adriaarj Cooolttoa ` API 05232 *5 pr. X* X. Untar, Air MedlOil AdTlM7 CoadtlM c/c n Atlanti* Balalas Ci SdO Boatti Iroo* S treet fhllalalphla 1, Saar Poetar L inieri The Ornerai Coaolttee, P lelaloa of Solalas haa f t tha Chalan af th Piritica of Balalas appaiai a o antera af aail fintai Cfitte ta rarlav th past art ef aall indicai Ariamj Scarnite* aa lt portalaa ta flalaha* aa* aaflultel palmi ana proteota^aa* ta ratinar/ fegatim aa taU aa ta fetore art Ttkli fiali, ol>tti!!^4tt'ttt atryo aa lt talo ehoal he vlth aaafe awhaaiai aa lt faala ahoalA ha aatahlahal ta intra th beat poaalhde th patro&am la la a tr j ani th oaera af petrolera p ro te tte " The Qeneral Cenelttee alea haa ajreel enealaoaelyi "th a t tha U n P raallaat fa r B alalas ahnoll eootfar dth tha Chaina a f tha S a fe t/ ConUttaa of ta Boari ta lataaolaa t a t e or a a t a eanhanlaa aaa ha art a* a a t terah j tha Maliirai Airlaorp Canaittee aaa ha fwnlaha* A lraat aaalataaa aal alTlea af faallfled raflaara* P irn n a l ta tk la agraaaant, V L. Stewart , JT ., C halana, t e m i . Craniite e, t t t t a l n af B alalas, haa acaferte* dth aa. B o rsiti/ tha n rtlas-o at a f tha am heelaa aneghi h / th fin o r a ! Coaadttaa re a li ha fa c ilita te * an i a f i l l e ! h / Jo la t oonfaraane aa* ail ahora1tm a f a n te r a of tha rafJm ry eeboceadteo, ttd e la ta ha appcdala* h / Nr. i t e r i , n i f i apela! aohca n d tte a e f aal l aal ao n d ttaa a t e n mah par night appolat. na!l an--eat th a t joa nomini nate d lr e c tl/tte * ) * ? B tenart'aa* te a te r tha aaiTlaaa a f a f i l a i aahaianlttM of a rtln a l ocaadttea API 05233 ^ V_. K. L i n d e r - h a i ^ a n -* Me(^i c a ^- A d v i s o r y C o m m i t t e e ^/o The A t l a n t i c R e f i n i n g C o m p a n y o-0 South B r o a d S t r e e t t^ladelphia. Pa. . ^ear Dr. Linder: The General Committee, Division of Refining has resolved - "That the Chairman of the General Committee of the Division of Refining appoint a subcommittee composed of members of said General Committee to review the past work of said Medical Advisory Committee as it pertains to finished and unfin ished petroleum products, and to refinery operations as well as to review work now under way and programs, if any, for future work in this field, and to recom m e n d to the G e n e r a l C o m m i t t e e such steps as it feels should be taken, together with such mechanism as it feels should be established to secure the best possi ble results from the standpoint of the employees of the petroleum industry and the users of petroleum p r o d u c t s ." The G e n e r a l C o m m i t t e e a l s o h a s a g r e e d u n a n i m o u s l y - "...that the Vice President for Refining should confer with the Chairman of the Safety Committee of the Board to determine whether or not a mechanism can be worked out whereby the Medical Advisory Committee can be furnish ed direct assistance and advice of qualified refiners." P u r s u a n t to t his a g r e e m e n t , W. L. S t e w a r t , Jr., C h a i r m a n , General Committee, Division of Refining, has conferred with me. Dossibly the working out of the mechanism sought by the General committee would be facilitated and expedited by joint con ference and collaboration of members of the refinery subcommittee, which is to be a p pointed by Mr. Stewart, and of a special s u b c o mmittee of m e d i c a l c o m m i t t e e m e m b e r s w h i c h you m i g h t a p p o i n t . API 05235 T 9 - O_ If such a course of action seems appropriate to you, I woUXd suggest th a t y o u c o m m u n i c a t e d i r e c t l y w i t h Mr. S t e w a r t and i ' tend1* the s e r v i c e s o f a s p e c i a l s u b c o m m i t t e e o f m e d i c a l c o m m i t t e e ^embers which could assist the refinery subcommittee in its review 0f the past, p r e s e n t a n d f u t u r e A P I m e d i c a l r e s e a r c h p r o g r a m a n d in w o r k i n g o u t a m e c h a n i s m t o a c c o m p l i s h the r e s u l t s s t a t e d in the ^solution. cc - W. L. S t e w a r t Jr. F. M. P o r t e r W. T Gunn To be signed by J o h n R. S u m a n , Chairman, Safety Committee of API Board of Directors : {A*-** 0! I i ^* > -,S API 05236 P s^-nary i ? , 1252 Mr. 2. K. Landra aif Cil CarporatL P.C. Bax 1166 Pittsburgh >0, Penneyltanla tear "BuxyT*: If you plan to h la Cincinnati ra Tuesday, Potruary 26, yoa night plaa aleo to m a a l n for the aaatlag of the Halsen n b c c o a l t t M on Fminvmrj d'f. I ball** yoa vili be larited to do eo buttane of the sadden rineth of Doctor Lang ho as a -- liar of tbs special Coordinating Coeadttee of the Medical Adrlacry L JBmttee. Tory truly yours, DVS:e ce: Ir. X. L TInder fir. M. I. geaquiat API 05237 gggbere of the Raaoarah Project Adriaory Conni ttoo Raaoarah Project IIC-1, Aaarican Patrol* inatltuto poor Sira* The attached ooMunloatlan of February 15, 1968 fro Hr* ?. J. SuIIItob la aolf-ax*lanatory and la for your famtiou I an placing Mr. SullXran*a roquaat that the B?A Conaittoo propara a roport outlining tba pact and propound futuro itlritloa on Caroinogonialty at tha Kettering Laboratory on the gioia for our oootlag la Olnolanatl next Tuoaday February 86. Stale ill not regain any dlaauaeion before the Kettering Labora tory taff other than jour opinion and rota aa to another or not the RFA Conolttoe ahould proparo auoh a roport Vary truly youra OltOH Attach. L I. Adana U C. Beard J r . C laffar Daria 1 . 0 . t* A. S t t a r d t , 1 . 0 . f* ft. Frank M. D. J* 8 Rina M.D. * ft. London 8 9 . Macton la C. Ulthoff t* X. Shepardaon 2. K. Linder. M.D. Mr. D. V. 3troop ^ M. ft. IcoquietVlUJfc Chairman. Reaearon Project Adriaory Committee API 05238 RESIDENT O/'* ^ ^ **'***n i t t s b u r c -:-: 3c, PA. Februar ./ 3, -- c/bo-- ^r# j. 7.'. Newquist, Chairman Research Project MC-i Advisory ->e Texas Company fVb last I;2r.d Street '^w York 17, New York Committee -er Newquist: . A t the meeting of the General Committee, division of R e fining, API, in Chicago last November, a resolution was passed "Chat she chairman of the General Committee appoint a sub-committee composed of members of the General Committee to review the past work of the Medical Advisory Committee as it pertains tc finished and unfinished petroleum products, and to refinery operations, as well as to review work now under way and programs, if any, for future work in this field, and to recommend to the General Committee such steps as it feels should be taken, together with such me c ha n ism as it feels should be established to secure the test possible results from the standpoint of the employees of the petroleum in dustry and the users cf petroleum products." In a c c o r d a n c e w i t h the a b ove r esolution, Mr. "'.L. Stewart, Chairman of the General Committee, appointed a Study Committee com posed cf the f o l l o w i n g m e m b e r s of the G e n e r a l C o m m ittee, to r e v i e w the w o r k of the Medical A d v i s o r y Committee, D e p a r t m e n t cf Safety, and re port to the G e n e r a l C o m m i t t e e at San F r a n c i s c o on May 15,1?52: mx KTJ Sullivan, Ur> K Davidson H . 7'. Ferguson j . P. Langfitt Chairman Gulf Oil Corporation Standard Oil of California Humble Cii Refining Co. The Pure Oil Company Upon receipt cf Mr. Gunn's letter of January 23, advising me of the appointment as Chairman of the Study Committee cf the lateral Committee, Division of Refining, I wrote the ether members cf the committee on February 1 giving my views on a method cf action, i copy of my letter of Februaryi/is attached hereto. I now have replies from my letter of February 1 from each member of the Study group and they are in reasonable agreement with my suggestion that the Research Project MC-1 advisory Committee prepare a report outlining the past and proposed future activities sf the projeet at Kettering Laboratory. If you are agreeable to accepting the preparation of the report, I thought you would like to '^ow 0f the task before the meeting of your committee in Cincinnati :r- February 2 6 . V.'ill you please let me have your comments. "ML/rj -/tt. Cc: Mr.G.; . Davidson Mr. H.W. Ferguson Mr. J.P. Langfitt Very truly yours, (signed) T. J. Sullivan, ^Ice-President. API 05239 February 1, 1952 y~, G. '. D a v i d s o n , V i c e - P r e s i d e n t , -'Iqndard Oil C o m p a n y of C a l i f o r n i a , Bush Street, San F r a n c i s c o 20, C a l i f o r n i a . 'r. H. 'V. F e r g u s o n , V i c e - P r e s i d e n t , liable Oil & R e f i n i n g Company, o. Box 2180, l-^uston 1, Texas. Vr. J F. L a n g f i t t , V i c e - P r e s i d e n t , 1-ne Pure Oil C o m p a n y , Bast Wacker Drive, Chicago, Illinois. jen tie men: Please refer to Mr. G u n n ' s l e tter of January 23 advising that Mr. S t e w a r t h a d a p p o i n t e d y o u g e n t l e m e n , a l o n g w i t h the u n d e r signed, as a c o m m i t t e e to r e v i e w the w o r k of the M e d i c a l A d v i s o r y Committee, D e p a r t m e n t of Safety, and to repo r t to the G e n e r a l C o m mittee at the San F r a n c i s c o m e e t i n g in May. For your ready reference, I am attaching hereto a copy of Item X I I of M i n u t e s of M e e t i n g of the G e n e r a l C o m m i t t e e , h e l d on November 6 , 1951, at the Conrad Hilton Hotel, Chicago. Since the m e e t i n g in Chicago, a R e s e a r c h Project MC1 Advisory Committee has been appointed by Dr. Newquist (The Texas Company), Chairman of the Sub-Committee cn Carcinogenicity, by direction of the Medical Advisory Committee in their meeting on November 3, 1951, in C h i c a g o . The p u r p o s e of this c o m m i t t e e is to afford a " closed b o n d of u n d e r s t a n d i n g b e t w e e n c o m m i t t e e m e m b e r s and r e s e a r c h w o r k e r s . " T h i s c o m m i t t e e m e t in C i n c i n n a t i on N o v e m b e r 26, 1951, w i t h Dr. K e h o e and h i s a s s o c i a t e s , and m a n y of the problems or o b j e c t i o n s ( b r o u g h t out p r e v i o u s l y b y some M e d i c a l A d v i s o r y Committee members) to a trend b y K e t t e r i n g L a b o r a t o r y to e x p a n d the sccpe of the p r o j e c t b e y o n d its o r i g i n a l o u t l i n e w e r e s e t t l e d to the satisfaction of the Medical Advisory Committee. As a safeguard to <eep the p r o j e c t at K e t t e r i n g L a b o r a t o r y r u n n i n g in a m a n n e r that would be s a t i s f a c t o r y to the r e f i n e r s , p e r i o d i c m e e t i n g s of the R e search Pro j e c t MC-1 a d v i s o r y C o m m i t t e e are to be held, e v ery two or three m o n t h s , at K e t t e r i n g L a b o r a t o r y . T h e n e x t m e e t i n g is s c h e d u l e d for F e b r u a r y 26-27. The m a k e u p of the R e s e a r c h P r o j e c t M C - 1 A d v i s o r y Committee is as fellows: Medical Doctors: M. N. N e w q u i s t , C h a i r m a n Kieffer Davis (Phillips Petroleum Company) R i c h a r d E c k a r d t (S t a n d a r d O i l D e v e l o p m e n t Co.) T. M. F r a n k (Pan A m e r i c a n R e f i n i n g Cor p . ) C. R. H i n e (Shell Oil C o m p a n y ) 2. K. L i n d e r (Atlantic R e f i n i n g Com p a n y ) API 05240 Davidson Ferguson _0_ Langfitt '* * r>* J *i visory M e m b e r s : E, W. M a m s (Standard Oil Company - Indiana) L. C. B e a r d (S o c o n y - V a c u u m Cil C o m p a n y ) R. M. L a n d o n (Gulf O i l C o r p o r a t i o n ) K. G. M a c k e n z i e (The Texas Company) R. M. S h e p a r d s o n (Standard Cil D e v e l o p m e n t Co.) R. C. M i t h o f f (Standard Oil C o m p a n y of Calif.) In my opinion, the above group of six medical doctors and six a d v i s o r s w h o h a v e b e e n f o l l o w i n g the p r o j e c t at K e t t e r i n g laboratory are b e t t e r q u a l i f i e d to p r e p a r e a r e p o r t for s u b m i s s i o n 1 0 the G e n e r a l C o m m i t t e e t h a n the fo u r of us* It is m y s u g g e s t i o n hat we a s k Dr. N e w q u i s t , as C h a i r m a n of the S u b - C o m m i t t e e , to have his c o m m i t t e e (the a b o v e - n a m e d g r o u p ) p r e p a r e s uch a r e p o r t cr. :he MC-1 r e s e a r c h p r o j e c t at K e t t e r i n g L a b o r a t o r y , o u t l i n i n g p a s t and f u t u r e a c t i v i t i e s of the p r o j e c t at K e t t e r i n g L a b o r a t o r y for our approval and / o r e d i t i n g b e f o r e s u b m i s s i o n to the G e n e r a l Committee. If you are agreeable to the above-outlined procedure, will you p l e a s e let me k n o w p r o m p t l y so I c a n a d v i s e D r . N e w q u i s t a h e a d of the F e b r u a r y 26-27 m e e t i n g of the R e s e a r c h P r o j e c t MC-1 A d v i s o r y Committee. However, if any of you have thoughts other than those proposed here, let me know, as you may have a better and easier way to car ry out the a s s i g n m e n t . Y o u will note that the above covers only one phase of the Medical Advis o r y Committee - that of c a r c i n o g e n i c i t y . It will be a simple matter to have the Chairman of the other sub-committees of the M e d i c a l ' d v i s o r y C o m m i t t e e p r e p a r e s i m i l a r r e p o r t s , as their activities are m i n o r c o m p a r e d to the w o r k and e x p e n s e on carcinogenicity. May I have your comments. Very truly yours, (signed) RML/rj Att. T. J. S u l l i v a n , Vice-President. API 05241 XII ZXZC7TIVZ SES3ICN Mon-ner.bers of the General Committee were excused from -r room, and the Committee met ir. Ex ecutive Session tc consider fetters p ert ai nin g to the Medical A d v i s o ry Committee of the D e partment of Safety. K. G. Mackenzie- of The Texas Company addressed the C-enerai Committee ex pressing some concern about matters p e r t a i n ing specifically to re fining activities up ^ n wh ic h the Medical Advisory Committee should have the advice and consultation of refiners. Mr. Mackenzie offered the following resolution: '''HERE'S, the Medical 'aviscry Co mmittee of the D e p a r t ment of Safety reports solely to, -and receives directions solely from, the Safety Co mmittee of the 3oard of Directors, and '.'.`HERE'S, said Medical A d v i s o r y Committee in its studios cf the possible p ro du c t i o n of skin cancer by p e t r o le u m products has extended its operations much beyond the medical aspects of the problem to include such matte rs as Source, physical properties and chemical composition of charae stocks. Methods of refining including temperatures pressures to which said charge stocks are subjected, and a complete descript ion of other refining seeps. Physical and chemical properties of the products of such refinery operations together wi t h dispo sitio n cf such products. Physical together with the chemical and chemical properties of finished petroleum products with the quantitive composition cf such finished products, source, method or methods of refining, and physical and properties of said components, and WHEREAS, said Medical Advisory Committee has had still has before it the possible development of methods of to remove constituents of said p e t r o l e u m products which it believes may produce skin cancer in man, and and refining WHEREAS, as the af oresaid n o n- me di ca l activities come properly wi th i n the scope of the D i v i s i o n of Refining, be it RESOLVED, that the C h a i r m a n of the General Co mmittee the Di vis io n of Re fin in g appoint a subcommittee composed of members of said General Committee to review the past work of said Medical A d v i s o r y Committee as it pertain s to finished and u n finished p e t r o l e u m products, and to refinery operations as well as to review work now under way and programs, if any, for future work API 05242 -2- m this field, nd to recommend tc the Gener al Co mmittee such steps fts it feels should be taken, together with such m e c h a n i s m as it feels should be establishe d to secure the best possible results fron the standpoint of the employees of the p e t r o l e u m indust ry and tke users of p e t r ol e um products, and be it F U R T H E R R E S O L V E D , T h a t this s u b c o m m i t t e e be r e q u e s t e d to issue a p r o g r e s s r e p o r t at the M a y M e e t i n g of the G e n e r a l C o m m i t t e e in San F r a n c i s c o i n 1952. Upon the m o t i o n d u l y made and seconded the fo llowing action was taken: /CTION: The Resolution was passed unanimously. In addition, there was u n a ni m o u s agreement that the Vice President for Re fi n in g should confer with the C h a i r m an of the Safety Co mmittee of the Board to determine w h et h e r cr not a mechanism can be worked out whereby the Medical Advisory Committee can be furnished direct assistance and advice of qu alified refiners. API 05243 -WOUIST. M. D. ^ N* -fO*CAW OIHECTO THE TEXAS COMPANY 13S EAST 4 2 nd STREET NEW YORK 17. N. Y. February 20, 1952 f o Members of the R.P.A. Committee of Subcommittee on Carcinogenicity Dear Sira: I am attaching the agenda for the meeting of the R.PJL. Committee at Kettering Laboratory on F e b r u a r y 26, 1952. I am Trusting that you will be able to attend the meeting, Very truly yours, KHR :RMS ENCS. E. V. A d a m s L. C* Beard, J f Kieffer Davis, MD. R. E. E c kardt, V.D. J. M. Frank, M.D. C. M. E i n e R* V. L a n d on E. K. Linder, M.D. K. 0. M a c k e n z i e R. C. M i t h o f f R M. S h e p a r d s o n Up . D. V. S t r o o p Dr. R o b e r t A. K e h o e Chairman, Research Project Advisory Committee API 05244 RP(MC-1)A AGENDA Committee meeting - Kettering February 2o, 1952 9:30 A.M. Laboratory 1 - Consideration of items listed in "Standardization of Biological Testing Methods" as prepared by Dr. Kehoe and associates. 2 - Report on current status of works (a) O n i t e m s a c t e d o n at t h e N o v e m b e r 2o, 1951 meeting of the R.F.A. Committee and Kettering Laboratory Staff as reflected in the minutes. (b) O n i t e m s , if any, n o t i n c l u d e d i n "a" a b o v e . 3 - Questions from committee members (a) J u s t i f i c a t i o n f o r p e r f o r m i n g a n y c o n s i d e r able amount of work on carcinogenicity? lj. - R e l a t i o n of o i l m i s t l u b r i c a t i o n to l u n g i n f e c t i o n a n d c a n c e r . 5 - Expediting of epidemiological surveys. 6 - Preparation by the R.P.A. Committee of report on past and future activities, including budgetary requirements, of the Sub-committee on Carcinogenicity for the General Committee, Division of Refining, API. 7 - Publication of article on this subject by Dr. Kehoe - when and where? 8 - Budgetary requirements in light of research program (a) F o r y e a r b e g i n n i n g J u l y 1, 1 9 5 2 (Dr. K e h o e ' s e s t i m a t e attached) (b) " " " " " 1953 9 - Format of progress reports prepared by Dr. Horton. 10 - O t h e r b u s i n e s s . 11 - T i m e a n d p l a c e o f the n e x t m e e t i n g . ft) API 05245 .,,.IIY Ui. uluCIririvil COPY Department of Preventive Medicine and Industrial Health Kettering Laboratory ^ilegs Medicine - Eden g ; clnnati 19, Ohio Avenue Fe b r u a r y 11, 1952 D. V. S t r o o p ^ erican P e t r o l e u m Institute cq west 50th Street d# York City 20 jgar Mr. S t r o o p j I send yo u h e r e w i t h the estimated budget f o r the year b e ginning J u l y 1, 1952. It is b a s e d o n c e r t a i n c o n j e c t u r e s , of c o u r s e , if the work continues as we anticipate that it will and probably sh o u ld , this is a fairly realistic estimate. The status of the funds at the end of your fiscal year (July 1 , 1 9 5 2 ) c a n b e e s t i m a t e d w i t h f a i r p r e c i s i o n as s o o n as o u r iccounts f o r the c a l e n d a r y e a r 1 9 5 1 are f i n a l i z e d . T h i s w i l l come in the n e a r f u t u r e , at w h i c h t i m e y o u and w e w i l l b e a b l e to v i s u a l i z e the s i t u t a t i o n . I trust that this information will be satisfactory for present p u r p o s e s . Cordially yours, RAK ef Dictated but not read, be. / s / R o b e r t A. K e h o e R o b e r t A. Kehoe, M.D. API 05246 3TTDGST D A T A F O B A M E R I C A N P E T R O L E U M INSTITUTE Investigation of Cutaneous Carcinogenic Materials by The Kettering Laboratory Estimated budget f r o m July 1 , 1952 to July l t 1953 ComperiSaticn ^ o r P e r s o n n e l ( i t e m i z e d b e l o w ) Supervision - g e n e r a l Chemical T e c h n o l o g y a n d E p i d e m i o l o g y (Direct S a l a r i e s I t e m i z e d b e l o w ) principal investigators Experimental and Technologic Epidemiologic Surveys Research Chemists Biological Testing (Direct salaries itemized below) Gross pathology and animal records Microscopic pathology Technicians (testing) Total Compensation as Direct Salaries $43,600 $ 5,000 8,000 5,000 12,500 25,500 2,600 2,000 3,700 38,800 8,300 . Indirect Salaries (Itemized below) Initial postmortem examination Preparation of microscopic slides 1,200 3,600 Othr E x p e n s e Supplies (indicated below) Supplies for Technologie and Epidemiologic work Supplies for Biological Testing Travel Animals Overhead - all other items including indirect salaries that cannot be itemized, pensions and annuities, educational expense heat, light, power, secretarial service, li brary service, janitor service, general maintenance, etc. 3,500 3,500 4,800 7,000 5,000 2,600 46,560 Total e s t i m a t e d B u d g e t f o r a l l p u r p o s e s $104,760 API 05247 rarvBBirr or cncm uai PBOJICT 0 CABC2KXBI2CIT 1-1-52 7-1-51 1-1-51 7-1-50 1 - 1-50 7-1-49 1-1-49 7-1-48 1-1-48 7-1-47 1-1-47 7-1-46 2-1-46 ' $ 31,692.42 50, 000.00 9,065.12 50, 000.00 JT,963.39 \ 49,413.00 0 65,00c .00 0 0 0 0 6 , 000.00 2- 21-52 052A6 February 29# 1952 Dr. M. Y. T e w q u i s t Medical Director The Texas Company 1 3 5 3* l*2nd S t r e e t New York 17# New York Dear Doctor Newquist: Before the Memorandum from the Kettering Laboratory, dated February 26, 1952# is dupli c a t e d for distribution as part of the minutes of Tuesday's meeting of the Project Advisory Committee, one error should be corrected. Under section S.l*# the number 6 (the API Research Project at Ohio State University) s h o u l d be c h a n g e d to lj.5 . Sincerely yours. AWHxmJg CC: Mr. D. V. St**oop A. Wesley Horton API 05249 T Iferch 6, 1952 7>r. M. R. Sovgulct, Chanas S-orictiittso on Csrclnosenlcity e/o Th fossa Coapoay Ijp ls : 4n Street Reo Torte 17, Reo lock Soar Doctor fcvtilsti lor 7 r eutmttal to tfco Sakocsslttee on Coreincessicity us -- low copy of Doctor Eekoe'e letter of Merck kth d t k rcrlu d jrvseatatQa of te 1952*1953 budget far tko isfeetigstiaa of cetoaooee carelaoesnlc aterale. cry truly yours, i DTE JO Tftic looaro ce: Dr. Botart A. Xfckoo m t lao *t o m ^ bdicins- *m * t UNIVERSITY OF CINCINNATI DIPARTRSNT OF FM V IN TIV t MEDICINE AND INDUSTRIAL MIALTH M a r c h 4, 1952 CARLS ADORSSS: EXTLAE. CINCINNATI TELEPHONE! CAFITOL MM Mr< D- V. 5 t r o o p \-erican Petroleum Institute cj V e s t 5 0 t h S t r e e t jjev Y c r k C i t y 20 * pear Mr- Stroop: . At the last m e e t i n g of the special Committee w i t h us on February 2$, it w a s s u g g e s t e d that the b u d g e t f o r the n e x t y e a r b e r e v i s e d ia its m a n n e r of p r e s e n t a t i o n . I h a v e d o n e t his in a w a y that is probably m o r e c o m p l e t e t h a n is n e c e s s a r y . I n a n y c a s e , it is illust r a t i v e of the f a c t s as to w h a t w e s p e n d m o n e y f o r , a n d I Relieve that n o one is l i k e l y to c o n c l u d e that our "overhead" is highly excessive. If this s u its y o u r p u r p o s e s , It c a n b e s e n t o u t i n this f o r m . If you t hink It b e t t e r to e xpres s the same f i g u r e s in a n o t h e r way, I'll b e g lad to f o l l o w y our suggestions. With best regards, e Incerely yours EAK ef API 05251 BUDGET DATA FOR AMERICAN PETROLEUM INSTITUTE investigation cf Cutaneous C a r cinogenic M a t erials -7 The Kettering Laboratory timated budget f r o m J u l y 1, 1952 to J u l y 1, 1953 ^.pr ^ g n s a t l o n f o r P e r s o n n e l Supervision Chemical technology Principal investigator Research chemists Total $ 8,000.00 12,5'OO.u. Biological Testing Gross pathology and records Microscopic pathology Technicians (animal tests) Post-mortem examinations Preparation of microscopic slides Total 2 ,000.00 2 , 200. 0. 5 ,70 0 .0 0 1 , 200.00 5,500.00 Epidemiology Principal investigator Total 5*300.0.-' Other Personnel (indirect) Administration (General adminis tration, accounting, etc.) Other Secretarial and clerical Library Animal Care Glass-ware washing Draughting Janitor and sundry Total 4,500.0. 15,900.00 Total Compensation for Personnel Miscellaneous Expense Scientific supplies General supplies and replacements Annuities and pensions Travel Animals and food Maintenance, heat, light, power , telephone service Stationery, postage, office supplies , and medical art 7 ,000.00 5,520.00 4 5 ,,260 .Q'j 000.00 4 , c0j .00 5 ,7 0 0 .0 1 ,0 7 0 .jj 95>j 0 0 .00 2 0 ,500.00 1 5 ,500.00 5 ,000.00 20.550.00 6 4 .5 5 0 .0 0 API 05252 ^g^ellaneous Expense Continued Educational expense, development vork and periodicals Total Miscellaneous Expense r0tal e s t i m a t e d expend i t u r e s 7 ,l6o.QQ 4 0 , 4 1 0 . Ju $ 1 0 4 , 7 o 'J.0j * API 05253 Copy tram D. Btroot to Dr. M. 1 . feso u lst - V lb-52 coft uvzvxssin or c n c m m Peparbmnt o f Preventive Msdlolno and Industrial Health fettering laboratory o f Medicine - Sden Atom* 19, Ohio March 12, 1992 Mr. D. V* Stroop American Petroleum In stitu te 50 Vest 50th Street le v York C ity 20 Pear Mr. 8troop: For your lnfomnatlon I am sending you herevith a statement of expenditures made on behalf of American Petroleum In stitu te during the fourth quarter o f 1991 The check in the amount of $3 1, 692.U2 vhloh vaa acknowledged in my le tte r of December 29 was received too la te fo r inclualon in the accounting reecrda o f the U niversity, and therefore la not shown on the statement as received in 1991* I believe that otherwise the statement is self-explanatory, bnt i f you have any questions or coements, Pootor Zehoe would appreciate your bringing them to his attention. Tery toruly yours, /a / I . I . Jtrtlage I . S . Fortlage, Secretary to S r. Xehoe ef API 05254 WXVXBBXTI or CIKHIATI uruuaso l a k r a t o b i a c c o d i t or a m b i c a i m m a n a m o n Tor the Fourth Quarter 19% (Based on Proportion at T i m Aetna! ly Spani on Project) gobert A. Kishoe - Buporrlslon fraacis Beyroth - Oenaral Technical 8uperrlslon John Pbair m Vesley Horton - Coordination of Sxperlaental passai Tye a Teohnloal Assistance lath Piarle - m m Dorothy Templeton* V Hurloa Duvall e st ii lalph Denham - t m Cairi# Sivley - ** VI Valdo Toankor - v m Vork /Tank Cleveland - Pathological Assistance Earl ira n tle - Technical Assistance Trank 2>ntra - Pathological Assistance 90.00 67.50 1,375.02 2 ,1 3 3 .2 k 1 ,1 2 5 .0 0 1,200.00 563.16 295.2k 3k5.00 30k.82 79.12 8k.23 28.00 9.26 ^rTLUJDtODB gPElSE Purchase of Anlaals ............................................................... Treiellng Expense ...................... laboratory Buppllaa ... Proportion o f S ecreta ria l, Library, Jan itors. Wash Boys, Draftsmen, Shipping Clarks. Animal Caretakers, a te . . . U stopathologioal Preparation ............................ Proportion of la s t . Gas, E le c tr ic ity , Steam, Telephone, Postage, Panelone, A m it ie s , Maintenance, Animal Food and Supplies, e tc ................ 7,699.59 306.00 826.52 361.79 7,5^1.72 1.657*50 6,330*77 T0TA1 M anna Available fa r Tnrther Mark a t End of 3rd Quarter 1951 ............................................... $k3,718.95 2 k ,723.69 Expenditures - kth Qnarter 1 9 % ................. . 2k.723.89 lalaaoe Available for Further Vork at Sad of kth Qnarter 1 9 % ......................... 18,995.06 API 05255 API 05256 t U*0*T0*t K m --- J y UNIVERSITY OF CINCINNATI DEBARMENT OF FUVINT1VC MEDICINE AMO IMOUSTNIAL HEALTH March 12, 195? CABLE ADOBESE. ERLAB. CIHCIMHAT! TELETHONS: CAOTM. MM wj,. D. V. t r o o p , D i r e c t o r meritar. P e t r o l e u m I n s t i t u t e - ; Vest 5 ;th r treet $ 5v York City 20 ' ^ear Mr. troop: per your information I am sending you herewith a statement of oj-penditures made on behalf of American Petroleum Institute during the fourth quarter of 1951* The check in the amount of 1,59 2 .-2 w h i c h vas acknowledged in my letter of December 29 vas received too late for inclusion in the accounting records of the University, and therefore is not shown on the statement as received in 1951* I believe that oxhervi?p :-';e iat pcitnt is se3'% e h 0 aria! c> 3 i:f> lcu 5'eve any questions or comments, * !Doctoiywould appreciate your bringing them to his attention. V e r y truly years, M L rortlag, ecretary Dr Kehoe ~ ef j^nc . API 05257 *) ) UNIVERSITY OP CINCINNATI KETTERING LABORATORY AC COURT OP AMERICAN PETROLEUM INSTITUTE For the Fourth Quarter 1951 (Based on Proportion of Tine Actually ' Spent on Project) hert A. Kehoe - jiacis Heyroth - Phair - ijssell Tye - Juth PieJ le _ . " orothy Templeton- Lyion Duvall - J^pb Denham - Jjrrie Sivley - yaldo Younker - *pan^ Cleveland - rarl Kraut le - pank Dutra - Supervision General Technical Supervision Coordination of Experimental Technical Assistance tt 0 0 0 0 0 0 0 0 0 0 0 Work Pathological.Assistance Technical Assistance Pathological Assistance 90 .0 0 67.50 1575.02 2135.24 112 5 .0 0 12 0 0 .0 0 565.16 295.24 345.00 304.82 79.12 84.23 28.0 0 9.26 SOUS EXPENSE purchase of Animals Traveling Expense Laboratory Supplies Proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers etc . . . . Hlstopathological Preparation ................................ Proportion of Heat, Gas, Electricity, Steam, Telephone, Postage, Pensions, Annuities, Maintenance, Animal Pood a n d Supplies e t c ........................................... 7699.59 50 6.0 0 8 2 6 .52 561.79 7541.72 16 5 7 .5 0 6 3 3 0 .77 TOTAL 24,723.89 Balance Available for Further Work at E n d of 3 r d Q u a r t e r 1 9 5 1 ......................... $ 4 3 , 7 1 8 . 9 5 E x p e n d i t u r e s - 4 t h Q u a r t e r 1 9 5 1 ................... 24,723.8 9 3alance Available for Further Work at E n d of 4 t h Q u a r t e r 1 9 5 1 ....................... 18,995.06 API 05258 A merican P etroleum Institute SO W E ST BOTH STR EET NEW YORK 2 0 . N. Y. March 20, 1952 To Members and Associates Subcommittee on Carcinogenicity Gentlemen: I am enclosing a copy of the minutes of the meeting of the Research Project Advisory Committee which was held at Kettering Laboratory, Cincinnati, Ohio, February 26, 1952 Will you kindly indicate your approval or disapproval of the actions and decisions of the R.F.A. Committee on the enclosed letter ballot and return it to me. Negative votes should be accompanied by an explanation. I vili also appreciate receiving any comments and suggestions you may have concerning the research project at Kettering Laboratory. Very truly yours, MNH:RMS Enclosures me: Members and Associates Medical Advisory Cozaslttee (Without letter ballot) Chairman, Subecasaittee on Carcinogenicity API 05259 of the Subcomiittee on Carcinogenicity Medical Advisory Coanlttee American Petrolevan Institute PLEASE MASS AKD HETURH TO: Dr. M. K. Nevquist, Chairman Subcommittee on Carcinogenicity c/o The Texas Company 135 Bast b2nd Street Rev York 17, Rev York Shall the actions and decisions of the Research Project Advisory Coanlttee, as shown in the minutes of the February 26, 1952 meeting at Kettering Laboratory, Cincinnati, Ohio, be approved by the Subcommittee: Yes Ro* Hot voting (* It is requested that any negative vote be accompanied by an explanation.) NAME COMPARI DATE API 05260 I For Information Only - Hot For Publlcatlon REPORT OH SECOND MEETING Research Project MC-1 Advisory Coanittee February 26, 1952 Kettering Laboratory Cintinnati, Ohio MEMBERS PRESENT OR REERESEMTED M. N. Nevquist, M.D. - Chairman E. W. Adams L. C. Board, J r . Kleffer Davis, M.D. Robert E. Eokardt, M.D. T. M. Frank, M.D. R. M. Landon E. K. Linder , M.D. K. G. Mackenzie R. C. Mithoff R. M. Shepardaon MEMBERS ABSEHT AHD HOT P C. H. Eine, M.D. OTHERS PRESENT Kenneth R. Fourcher, M.D. F. F. Beyroth, M.D. A. W. Horton Robert A. Kehoe, M.D. John J. Phalr, M.D. B. B. Reeve, M.D. API 05261 > -2- I PROPOSED OBJECTIVES AMD STUDIES The following memorandum was presented by Dr. W. A. Horton and pp, John J. Phair, with full discussion by those present: Experiments on Samples of High Potency to Improve Analytical Tools 1 . Emphasis on cracked sidestreams from F.C.C. and Coking units, and some cracked residua from T.C.C. units, which have exhibited much higher potencies than predicted on the basis of absorption spectra In the 350-^50 m al range. a. Contribution of white oil fractions to effective potencies (Initial work on API-8 and 71). b. Contribution of fractions, boiling below 675 F., to effective potencies. c. Catalytic Influence on carcinogenesis of dodecylbenzene used previously not dependent on highly branched side chain; same effect observed with straight chain 2 -phenyldodecame. d. Consideration of earlier work on limited application testa. 2 . Relative contributions of various types of polycyclic compounds to effective potencies of oils. a. Pyrene type (Including benzpyrenes) more important than non pyrene type In API-23, F.C.C. cracked sidestream. b. Reverse true In fractions 8-10 and 8-11, In which k-rlnged polycycllcs predominate, of API-8 , F.C.C. cracked residuum. c. Further experimentation planned along this line with the aim of developing correction factors to extend the range of applicability of available analytical techniques for estimating potencies. B. Experiments on Samples of Low to Moderate Potency 1. Untreated lube distillates. a. Spectra of fractions of Oklahoma, Kuwait, and lagunlllaa crudes received from British Medical Research Council. b. Comparison of spectra of distillates from Gulf Coastal crudes with thoee above and with spectra of API-5 6 , Mid-Continent paraffin distillate, and API-79, San Joaquin (California) naphthenic distillate. c. Prediction of potency of many of these dletlllatee from physical properties still more an art than a sclenoe; more study needed. API 05262 > -3 2. Experiments on skin creams and cleansing agents. . a. Tina of appearance of tuners Induced toy API-8 retarded toy barrier cream used (Experiments 312 and 306 described In report of September 25, 1951)* to. Further experiments along this line, using cream made up of lanolin and oilre oil. Qa Modification of Method of Presentation of Data on Individual Animal Experiments . 1. Inclusion of average weight curves (see examples attached). 2. Correction of tumor index curves toased on "normal" distribution of times of appearance of tumors. * a. Deviation from "normal" distribution ascribed to variations in health of animals. to. Average latent periods for tumor induction (and correlated values of relative potency, Pj^) toased on corrected tumor Index curves. D. Standardization of Testing Methods (see outline dated January 30, 1952) 1. Control of variations In health of animals. a. Efforts to prevent spread of Intercurrent Infections toy sterilization of cages and equipment and isolation of sick animals. to. Proportional reduction of total dosage of oil per application and area of skin covered to alleviate systemic toxic effects without lengthening the average latent periods for tumor Induction. c. Possible elimination of traces of highly toxic constituents of oils toy percolation through a suitable adsorbent (probably not applicable to residual fuel oils). 2. The relative carcinogenic potency, Pj, as a value dependent only upon the composition of the material tested, tout Independent of variations In strain of mice, frequency of application and dosage per application. . 3 . Beproducibility of determinations of relative potency, I^rj. a. Repeat experiments on selected oils for biological reproduc itoility. to. Application of statistical methods to analyze observed variance. API 05263 > -uprocuranant of Pure Hydrocarbons for Determination of Catalytic Effects (AlkylaranatlcB) and Identification of Polycycllcs Isolated from Oils 1. API Research Project 6 at Ohio State University possible source of 1-phenyldecane; other alkylaromatics from API Research Project *5. 2. Generous contribution by Dr. M. S. Neuman, Ohio State University, of methyl derivatives of chrysene, pyrene, phenanthrene, benzo-(c)-phenanthrene, and 1 ,2-benzanthracene. 3 . Possible sources of dlmethylpyrenes and benzacridines In Paris and Brussels being developed. U. Thanhs alBo due to Professor V. Bergmann, Yale, and Dr. R. N. Jones, National Research Council (Canada), for samples of perylene and various pyrenes. Central Cancer Registry (to date) 1. Reporting a. 872 case reports b . 12 ccaipenles 2. Tabulation a. Coding 50 per cent complete b. Punching 25 per cent complete API 05264 -5- LZGEKD FCB DATA S F ^ T C 01 INDIVIDUAL ETPERDENTS Symbols used in connection with average weight ourvea: ^7 Time of death of , th tumor-free mouse by "natural" causes. ^ Time of death of 1 th tumor-bearing mouse by "natural" causes. V or l 0 q Time mouse killed. Time of appearance of 1st papilloma in l th mouse. Time of appearance of grosB changes indicative of malignancy in tumor of l th mouse (when this symbol 1b used for a given mouse after its death, the malignancy of the tumor was determinable only by hlstopathology). Cumulative dose-response curves: .s-------- j Experimental curve for benign papillomas, ---- --- Hypothetical curve for papillomas, --------- Experimental curve for malignant tumors. S' API 05265 bkzm PMwnm cxr API-8, F.C.C. Cracked. Residuum ' API 05266 TIME AFTER FIRST P A u m 0 (weeks) s k im F A .n rrm o n m D a r t A P I-8 , f .C .C . C rack ed R esiduum AVERAGE WEIGHT OP SURVIVORS (grams) r) -8- Bank. f 1-2-3 T ^-5 f 6-7 8-9 T 10 McBEE KEY-SORT CODE API CASE STUDY Case Number Company Number For Future Use Banks B 1-2-3 B U-5 B6 Type of Tumor American Cancer Society Code Primary Site - Maryland State Code Stage of Disease Geographic Location B 7-8 For Future Uee B9 Age at Onset B 10 Sex and Race L 1-2 L 3-fc L 5 L 6 L 7 Primary Petroleum Occupation R 1-2 Secondary Petroleum Occupation R3 Principal Petroleum Product to Which Exposed Secondary Petrolero Product to Which Exposed Approximate No. of Years In the Petroleum Industry Prior to Onset Rk R5 R6 R7 Principal Other Occupation - National Code Approximate No. of Years Employed at Principal Other Occupation Principal Irritant Other Than Petroleum Approximate No. of Years Exposed to Principal Irritant Secondary Irritant Other Than Petroleum Approximate No. of Years Exposed to Secondary Irritant API 05268 > > -9- ^r^TOS ON TEE A B O V E MEMORANDUM; 1. It was the consensus that more rapid progress vould he made In developing an analytical tool If known carcinogens In pure solvents were also used In order to establish reliable base lines. 2. It was agreed to conduct a series of tests on a limited number of rabbits and mice using known carcinogens to establish comparative data and to coordinate, If possible, our findings with those of the British research workers. 3. It was agreed that we modify our previous action limiting studies on crude to Include a heavy distillate of heavy gulf coastal crude and that such a sample should be referred to In subsequent reports by Its spectroscopic character or other appropriate Identifying data rather than by Its source. This principle of labeling to be observed If other studies are made of domestic crudes even though no further studies are contemplated at this time. 1. It was agreed to study the effects of viscosity by altering the physical rather than the chemical properties of a sample, which could be accomplished by use of additives such as vlstanex, methyl stearates, acrylolds, etc. Mr. R. M. Shepardson offared to supply vlstanex In suitable quantities. 5. It was agreed that study of any possible accelerating or Inhibiting effects of trace metals on carcinogenicity be referred In view of the press of other work. 6. Dr. Phalr made a progress report calling attention to the need for adequate records In various medical depart ments throughout the Industry and to the need for obtain ing both historical and current epidemiological data. Practically all reports submitted have been historical. In view of the importance and urgency of collecting reliable blostatlstics, It was voted to request the Subcommittee on Carcinogenicity to Initiate prompt action aimed at adequate records and filing practices and the gathering of the Indicated reports for the central cancer registry. II PROGRESS OF WCRg SINCE LAST RPA COMMITTEE MEETHiO 11/26/51 A review of the minutes of the above meeting revealed that the items were either covered by the memorandum presented on 2/26/52 by Drs. Horton and Phalr or they were either under study or about to be studied. API 05269 > > -10- Vlth respect t o the study of Scottish shale oil and fractions thereof D r . Horton commented that the studies may be run outside of the API proJec t * Work on an analytical tool Is progressing, using a speetropiotonetrie approach. Eventual success Is hoped for, but considerable vork feoains to be done. Accomplishments, future objectives and budgetary requirements can only be determined as the vork progresses. With respect to accomplishment, It was the consensus that sufficient vork has nov been done at Kettering Laboratory on the subject of carcinogenicity to warrant publishing an article or report In an appropriate scientific Journal. Dr. Kehoe agreed to do this In the reasonably near future. Ill BUDGET Dr. Kehoe presented his estimated budget of $10U,76o for one year beginning July 1, 1952, covering research project MC-1 API as submitted to Mr. D. V. Stroop on February 11, 1952. ACTION It was voted that the budget submitted by Dr. Kehoe, totaling $10U,760 be recommended to the Subcommittee on Carcinogenicity for acceptance and that the budget so submitted show amounts assigned to the different types of vork such as chemical, biological and epidemiological studies. IT TIME AND P U C E OF NETT MEETING It was agreed that the RPA Committee would, meet again at the call of the chairman. V ADJOURNMENT There being no further business, the meeting was adjourned. Approved: M. N. Nevqulst. M.D. Chairman T. M. Frank. M.D. Acting Secretary API 05270 A merican P etroleum Institute 8 0 W EST SOth STREET NEW YORK 2 0 . N. Y. March 21, 1952 To Members and Associates Subcommittee on Carcinogenicity Gentlemen: For the personal and confidential Information \ of each of you I am attaching a copy of the Second Report on Mule Spinners' Cancer of the Joint Advisory Committee of the Cotton Industry. This includes a report of their Technical Committee on Mule Spinners' Cancer, all of which was received from the Institute of Petroleum. Very truly yours, MNN-.RMS Enclosure 7 T )~ n M. N. NEWQUIST^ M.D. Chairman, Subcommittee on Carcinogenicity me: Members and Associates, Medical Advisory Committee Members, General Committee, Division of Refining Dr. Robert A. Xehoe API 05271 jn g K T l A L Received 1? 19 Feb 1952 ffg rT freport is issued for confidential ini'ormation only ana on account are the contents to be published or communicated to other,3 - ---------------------------------------------------- -- --, 72, Bridge Street, MANCHESTER, 3- December, 1951 jo .. _h--.----M--.------C--h---i--e--f------I--n---s---p--e---c--t---o--r------o--f-----F--a---c--t---o---r--i---e--s-- SJf' Joint Advisory Committee of the Cotton Industry Second Report on Mule Spinners* Cancer In May, 1945, we forwarded to you a report from our Sub-Committee paling with the above subject and this was published by you and circu ited to the trade later that year. That report recommended that antiipiash and wiping-down devices be provided on mules, that lubricating oils should comply with the Manchester Cancer Committee's formula and te subject to an annual check as regards conformity to standard, and ttat all mule spinners should be subject to periodical medical examijation. In our covering report, we confirmed those recommendations md suggested that, if possible, Regulations should be made to cover diese points with the exception of wiping-dov/n devices which we conildered could well be dealt with by voluntary agreement. In 1948 highly refined oils, known as technical white oils, became nailable and, as the attached report indicates, there are reasons for believing that they are likely to be biologically inactive. Although complete confirmation of this would necessitate the lapse of a number of years, it seemed desirable to consider the possibility of the use of these oils in the cotton Industyry. Accordingly the Federation of hater Cotton Spinners Associations, Ltd., took the lead in convening committee representative of the industry, the oil industry and the Factory Department under the chairmanship of Dr. D. W. Hill of the British Cotton Industry Research Association. After its initial dis cussions, this Committee was adopted by us as a Sub-Committee and Weed to pursue its work. We now attach its Report advocating the use of these oils and htting up a standard to which they should conform. The Sub-Committee U satisfied from Its tests that the lubricating properties of these #lls are equally as good as those of the oils now in use. At the same Une, it was well known to them that many mills added a fatty oil to Jfceir mineral oils with the idea that lubricity was thereby improved: hey therefore envisaged that such additions might have still to be 'Uowed but pointed out that, after any such addition, the blended oil ^uld not be tested in the manner they proposed. API 05272  ^ y rPENTIAL 3 Page 2 As it seemed to us desirable that this difficulty should be re- 9 tfed 1 ^ possible, we asked that a further set of teats should be made, results of these tests are given as an Appendix to the report and confirm Its findings so closely that, in our view, the equal * tricity of these oils should be accepted as a fact and blending with oils 8hould not be allowed. In accepting this Report and commending it to your notice, we vC again considered the question of Regulations. As it seems to us the satisfactory use of anti-splash devices is not yet fully jtablished, mainly on mules on which paste is used, we now think that heir use should not be made statutory, at any rate for the present. Jjj accordingly withdraw our former recommendation on this particular ^ int and recommend that Regulations be made dealing with two points - m that the oils used for lubricating mule spindles be restricted to |jChnical white oils which meet the specification laid down in the port and (2 ) that all persons engaged in mule spinning be medically Ranined every six months in a manner conforming to the suggestions in the previous Sub-Committee's Report. We also recommend that the British Cotton Industry Research Association be urangements to continue the annual and independent U hitherto. asked to make testing of oils We wish to conclude by expressing our warmest thanks to Dr. Hill md all the members of his Sub-Committee for their work on this dif ficult question, which work we venture to think will be found to be by no means the least step forward towards the end which we all desire. We are, Yours faithfully, K. Blackburn, Secretary (Signed) T. P. Threlkeld (Chairman) R. Bramley-Harker, H. S. Butterworth, C. B. Clegg, G. B. Fielding, S. Bird, J. Lindley, A. Naesmith, A. C. C. Robertson, C. Schofield, F. Titherington, F. C. Toy API 05273 J REPORT ON FURTHER TESTS OP THE COMPARATIVE LUBRICATING VALUES OP STANDARD AND TECHNICAL WHITE SPINDLE OILS FOR MULES The Joint Committee on Conditions of Work in the Cotton Trade at its 13th Meeting on 23rd April considered the report of Sub-Committee * Before coming to a conclusion on the recommendations of the report ?t was agreed that further tests should be carried out on the lubri cating value of the Technical White Oils. Pour mills were suggested the Committee as being suitable for the tests. The necessary ar rangements were therefore made with these mills and samples of the inindle oils normally used were examined for their viscosity at the Shirley Institute and by the oil company. The two examinations agreed fairly closely and the average viscosities (in centistokes) were as follows :- Mill 1 15.8 Mill 2 18.4 Mill 3 18.1 Mill 4 18.0 jbese results are sufficiently close to Justify supplying the same jechnical White Oil to all four of the mills. The oil supplied had a riscosity of 17.4 centistokes. The power consumption of a mule at each of the four mills was assured first using ordinary spindle oil and, secondly, the Technical ihite Oil supplied by means of a specially-designed dynamometer fas tened to the rim shaft. At each mill the same mule was used for the oomparative tests and in each case the mules were run for a period of one to two weeks after changing oils before fresh measurements were tade. Plain spindle bearings were fitted on each mule. Particulars of the mules are given in Table I and the results of the power consurap tlon tests in Table II. API 05274 3 -# 1 TABLE I PARTICULARS OP MULES Mill NO. jjo. of spindles Gauge, inch Weight of full cop, oz:. yarn count Spindle speed, r.p.m. 1 1032 1 1/8 1.3 22 10,880 2 1074 1 3/8 1.6 22 10,200 1 1092 1 5/8 1.6 39 7,920 4 1080 1 3/ 1.6 10 8,200 - TABLE II HORSE POWER PER 1 , 0 0 0 SPINDLES Time Mill 1 Mill 2 Mill 3 Mill 4 of day i.m. Ordinary White Ordinary White Ordinary White Ordinary White j. 30 40 50 8.00 13 45 9.15 45 10.15 45 11.15 45 23.8 18.8 15.6 14.6 14.0 14.4 12.9 12.8 12.8 12.7 12.6 12.6 22.6 17.9 16.1 15.9 15.0 13.9 13.9 13.9 13.6 13.3 13.3 13.0 21.9 17.4 16.9 16.0 15.7 14.7 14.1 14.1 14.1 14.0 14.1 14.1 22.0 17.6 16.7 16.1 15.3 14.6 14.5 14.3 14.3 14.2 14.2 14.0 19.6 14.8 13.4 12.7 12.4 12.1 11.8 11.8 11.4 11.3 11.4 11.2 20.5 13.6 12.9 12.5 12.3 12.1 11.7 11.4 11.0 11.1 11.2 11.2 20.4 16.4 13.8 13.0 12.8 12.6 11.9 11.7 11.9 11.9 11.9 11.9 20.4 14.3 13.3 12.7 12.6 12.5 12.3 12.3 12.2 11.9 11.9 11.9 The results for Mills 2, 3 and 4 show that the power consumption ns almost Identical over a complete morning run for the two oils. The power consumptions at Mill 1 were initially the same hut the white oil led to a slightly higher power consumption after the mules had been running for a time. This may he caused hy the higher viscosity of the 41te oil over that of the oil normally used at this mill. The results, therefore, lead to the conclusion that the ordinary and the white plndle oils have similar lubricating values. API 05275 1 J REPORT OF TECHNICAL COMMITTEE ON MULE SPINNERS' CANCER p, rurelkeld, Esq., O.B.E., f''j(. Superintending Inspector of Factories, chairman, Main Committee on Conditions of Work in the Cotton Trade. M In July, 19^8, an ad hoc joint committee composed of representitives of the Federation of Master Cotton Spinners' Associations, Ltd., Iue Operative Spinners Amalgamation, the Factory Department, the oil leoopanies supplying spindle oils, and the Shirley Institute was con Itinted with the following terms of reference:- (i) To consider methods which may be adopted to reduce the incidence of Mule Spinners Cancer. (ii) To investigate the qualities of any oils that may be brought to the notice of the Committee, with par ticular reference to lubricating efficiency and viscosity. (iii) In particular, to enquire into the suitability of Technical White Oils for use in mule spinning rooms in cotton mills. (iv) To consider the comparative costs of any oils . found to be satisfactory. (2) After its first meeting, this ad hoc committee was placed upon a permanent and official basis by being reconstituted, in conformity with the recommendation made in April, 1945, by its predecessors, as Sub committee D of the main Committee set up to advise on the conditions of work in the cotton trade. (3) Like its predecessors, the Committee hold? the view that the met certain method of preventing Mule Spinners' Cancer is to restrict oils for lubrication to those which, so far as is known, are non-cancer Producing. From the first, therefore, the Committee directed its at tention particularly to consideration of the use and specification of tee technical white oils which have recently become available to the tedustry. Present information suggests that the cancer-producing, opponents of existing spindle oils, are aromatic and unsaturated in tearacter. Fortunately, methods have been davised, baaed largely 6n reatment with sulphuric acid, by which, according to the severity of tee treatment accorded, greater or lesser proportions of the undesirable temponents can be removed. API 05276 pgNTlAL Page 2 jt was necessary to establish whether such oils, when sufficient- (l) astically refined to remove all detectable quantities of the yj teriou components, were still suitable as lubricating agents or they could be made so by blending with fatty oils of harmless ^ racter. Pour mills assigned mules for trials which were carried ^ under the supervision of the Shirley Institute. The measure of ^Uricating power adopted was based upon a comparison of the power con- 1 otin the m u l*s under defined conditions with standard spindle i&P and with new ones based on technical white oils. At two of the 9 il3 the mules were driven by electric motors and at the others by the engine. Two technical white oils were used in the trials, one *ing a straight mineral oil and the other a compounded oil containing oil to confer additional lubricity. The results of the tests showed clearly that:- (i) In none of the trials was power consumption greater with the new oils than with standard oils. (ii) Although the trials were carried out on mules fitted with plain bearing spindles, no more frequent oiling was necessary with the new oils than with standard oils. . (iii) This in spite of the fact that the new oils were of slightly lower viscosity than the standard oils. (iv) There was no detectable difference in power consump tion between the straight mineral oil and the compounded oil. (6) The Committee therefore decided that technical white oils are completely satisfactory as mule spindle lubricants and that it is anecessary to provide additional lubricity by compounding with a fatty oil. The Committee recommends therefore that technical white oils ihould be used for the oiling of mule spindles, in view of the fact mat there is a prima facie case for their non-carcinogenicity and in lew of the fact that experiments have shown that their viscosity and lubricating qualities are at least equal to those of spindle oils at present commonly used. (7) The Committee, through its sub-committee, considered many posUble tests which might be used for characterising technical white oils thereby serving as the basis for a specification. Because of their taracterlstlc8 , the undesirable components Impart the colour usually asociated with spindle oils and the greater the degree of their re eval, the less coloured becomes the final product. The Committee is the opinion therefore that although the test for colour given in the Appendix to this Report may appear to some to be too simple to be tffective, it is the most conclusive test of drastic refining which we d e teen able to accept, it is, for example, so sensitive In the toge proposed that the addition of 0 . 5 per cent of an ordinary spindle U to an oil conforming to the Specification would reduce its Saybolt tolour from + 3 0 to + 2 5 . The Committee recommends therefore that the 'Us used for the lubrication of spinning mules should conform to the deification given as an Appendix to this Report. API 05277 ) Page 3 o n e difficulty which presented itself was that, in practice, it rLot uncommon to blend straight mineral oils with fatty oils with the *5sct of improving the lubricity of the former. No reliable test for a compounded oil has been placed before the Committee, which has i^^fore restricted the specification to the mineral oil. Moreover tests described above showed no difference in lubricating value beeeti a straight mineral oil and a blended oil. Nevertheless there may sotne who would prefer to use a blended oil and the Committee is of f* opinion that the addition of up to 10 per cent of suitable fatty such as acidless tallow, lard, sperm rapeseed, whale, ground-nut J neatsfoot would present no health hazard and that such an addition be permitted at the wish and discretion of the purchaser. p) jQ\ it is emphasised that the mineral oil component will be expected 1 conform to the Specification for Saybolt colour and the blended oil ; the viscosity requirements but the latter can no longer be tested 'tainst the Specification. The Committee recommends therefore that, so j. as possible, users of blended oils should take special care to en ;re that they obtain the right kind of oil and that suppliers should Militate this by supplying the oils in readily identifiable conijiners preferably under a registered name. ^ ^ 0) The Committee is of the opinion that the introduction of tech).cal white oils is a great step forward in the conquest of Mule Spin ors' Cancer and that the adoption of the recommended Specification 11 help to ensure their wide adoption in the industry. It regards .jfi whole question as one of the great urgency and importance and tnere*cre recommends very strongly that appropriate action should be taken 1make the Specification as effective as possible at the earliest ;cssible date. 11) The Committee wishes also to endorse the recommendations of their :redecessors, first, that there should be periodic medical examinations fall persons engaged in mule spinning and second, that suitable de rices to prevent the splashing of oil from mule spindles shall be rrovided so far as practicable. 12) In the view of the Committee the proposed Specification is severe ad more than adequate on the basis of present information to ensure aat oils used are innocuous. It is aware that a comprehensive pro*camme of research into the carcinogenicity of mineral oils has been initiated by the Medical Research Council and the Institute of Petro leum. It is possible that future investigations may make it desirable modify the proposed Specification. The present position is based on a facts as known at this date only. Future improvements are to be Jcped for and expected, and as they become available they should be de known to the trade. To this end the Committee recommends that it * kept in being and that the way be left open for a revision of the feecification as and when sufficient evidence to warrant it becomes railable. Summary API 05278 The Committee's recommendations are:- 1. That Technical White Oils should be used for the oiling of mule spindles. 2. That the oils used for the lubrication of mule spindles should conform to the Specification given as an Appendix to this report. Page 4 3 . That so far as possible users of blended oils should take special care to ensure that they obtain the right kind of oil and that suppliers should facilitate this by supplying the oils in readily identifiable containers preferably under a registered name. 4 . That appropriate action should be taken to make the Specification as effective as possible at the earliest possible date. 5 . That the Committee be kept in being and that the way be left open for a revision of the Specification as and when sufficient evidence to warrant it becomes available. The Committee wishes to express its appreciation of the valuable rvlces of its Secretary, Mr. Gregson, of the great help which it !gs received from the representatives of the oil companies and of 19, Collier and Miss Mone for the great care taken in the recording md preparation of the Minutes of the Committee Meetings. We are, Sir, Yours faithfully, Gregson Secretary (Signed) Douglas W. Hill Chairman S. J. M. Auld, H. S. Butterworth, F. Charnley, Robert Gregson, C. Henniker-Heaton, Albert Knowles, W. S. Moore, R. Murray, Charles Schofield, H. W. Stevenson, J. A. Witworth API 05279 APPENDIX Specification for White Oils for the Lubrication of Mule Spindles These Oils shall be hydrocarbon oils of petroleum origin which ave b e e n d r a s t i c a l l y r e f i n e d w i t h s u l p h u r i c a c i d a n d w h i c h are <nerally u n d e r s t o o d I n the P e t r o l e u m I n d u s t r y as ''W h i t e Oils". i They shall meet the following specification:- lour ^ - Saybolt A.S.T.M. DI5 6 -3 8 , (I.P. 18/42) not darker than + 3 0 . As an alternative the WOMA instrument may be used, in which case the colour shall be not darker than W.O.M.A. 3 . viscosity C e n t i s t o k e s at 140P. 1 6 - 2 1 . (I.P. 71/47). API 05280 u N new o u is t m. d. * M EEDDIiCCAALl Dd IiRr Ie c t o r TH E TEXAS COMPANY 135 EAST A2" STREET N EW Y O R K 17, N.Y. M a r c h 18, 1952 Mr. D. V. S t r o o p Department of Technical Service American Petroleum Institute 50 W e s t 50th Street New York 20, New York Dear Mr. Stroop: I b e l i e v e that the a t t a c h e d r e p o r t is of s u fficient importance to w a r r a n t sending it to the General Committee, D i v i s i o n of R efining. Mr. L. C. B e a r d and Mr. K. G. M a c k e n z i e c o n c u r in t h i s o p i n i o n . Y o u n a y w i s h to s u b m i t this m a t t e r to Ur. G u n n for p o s s i b l e d i s t r i b u t i o n to m e m b e r s of the G e n e r a l Committee. In any event will you kindly arrange to mimeograph and circularize the report to the m e mbers and associates of the Subcommittee on C a r c i n o g e n i c i t y and the others on the Medical Advisory Committee. Very truly yours API 05281 fM AMERICAN PETROLEUM INSTITUTE 50 WEST 50TH STREET N E W YORK 20, N. Y. .larch 13,, 1'9B52 f M e m o s r s -.nd A s s o c i a t e s Subcommittee on Carcinogenicity Gentlemen: J fP / y y I am a t t a c h i n g frrn paii e^lnfm m a t l e i a c o p y of the Second Report on Mule S p i n n e r s ' Cancer of the Joint Advisory Committee of the Cotton Industry. This includes a report of their Technical Committee on Mule Spinn e r s ' Cancer, all of v/hich w a s r e c e i v e d f r o m the I n s t i t u t e of P e t r o l e u m . Very truly yours, M. N. NEWQUIi Chairman, Subcommittee on Carcinogenicity I ?.. >c MNNrRMS SHC. me: Members and Aasociates, Medical Advisory Committee D a .. K e -h o e -- API 05282 3>is .erort i3 issued for canfli- atial infcrnaticr. or**7 sr.d on no account are^et, contents to De -ublished or oonmmloat>BRTgB, 3. others ---- mber, 1951. j3: fi.M. Chief inspector of Factories SONFIDENTIACi joint Advisory Committee of the Cotton TnAmtry , Second Report on Mule Spinners' Cancer f j?cci'v<& IP / j l<f fa *- v'ln May, 1945, we forwarded to you a report from our Sub-Comnittee dealing with the above subject and this was published by you and circulated to che trade later that year. That report recommended that anti-splash and wiping-down devices be provided on ntJ.es, that lubricating oils braila co.tij.Iy with the Manchester Cancer Committee's formula ani be subject to an annual check as regards conformity to standard, and that all mule spirmers she lid be subject to periodical medical examination. In our covering i i report, we confirmed those recomnendations and suggested that, if possible, p?relations should be made to cover these points with the exception of -^iplng-down devices which we considered could well be dealt with by voluntary agreement. 1 In 1948 highly refined oils, known as technical white oils, became available and, as the attached report indicates, there are reasons for ! believing that they are likely to be biologically inactive. Although complete confirmation of this would necessitate the lapse of a number of years, it seemed desirsble to consider the possibility of the use of these oils in the cotton industry. Accordingly the Federation of Master Cotton Spinners Associations, Ltd., took the leed in convening a cosmittee I representative of the industry, the oil industry and the Factory Department under the chairmanship of Dr. D.W. Hill of the British Cotton Industry Research Association. After its initial discussions, this Committee was adopted by us as a 3ib-Committee and asked to pursue its work. We now attach its Report advocating the use of these oils and setting up a standard to which they should conform. The Sub-Committee ia satisfied from its tests that the lubricating properties of these oils are equally as good as those of the oils now in use. At the same time, it was well known to them that many mills added a fatty oil to their mineral, oils with the idea that lubricity was thereby improved; they therefore envisaged that such additions might have still to be allowed but pointed out that, after any such addition, the blended oil could not be tested in the manner they proposed. As it seemed to us desirable that this difficulty should be removed if possible, we asked that a further set of tests should be made. The rer.'ltc of these tests are given as an Appendix to the report and they confirm its findings so closely that, in our view, the equal lubricity of these oils should be accepted as a fact and blending with fatty oila should not be allowed. In accepting this Report and conrnending it to your notice, we have again considered the question of Regulations. As it seems to us that the satisfactory U3e of anti-splaah devices is not yet fully established, mainly on mules on which paste is used, we now think that their uae should not be made statutory, at any rate for the present. We accordingly withdraw our former recosmendation on this particular point and recosmend that Regulations be made dealing with two points - (1) that the oila used for lubricating mule spindles be restricted to technical white oils which meet the specification laid down in the Report and (2) that all persons engaged in mule spinning be medically examined every six months in a manner conforming to the suggestions made in the previous Sub-Committee's Report. We also recommend that the British Cotton Industry Research Association be asked to nmite arrangements to continue the annual and independent testing of oils as hitherto. API 05283 t \ We wish to conclude by expressing our warmest thanks to Dr. and all the members of his Sub-Committee for their work on this diffi question, which work we venture to think will be found to be by no me the least step forward towards the end which we all desire. We are, Yours faithfully, E.K. Blackburn, Secretary (Signed) T. P. Threlkeld (Chairman) R. Bramley-Harker, H.S. 3utterworth, C.B. Clegg, G-.B. Fielding, S. Hird, J. Linoley, A< Naesmith, A.C.C. Robertson, C. Schofield, P. Titherington, F.C. Toy API 05284 REPORT ON FURTHER TESTS OF THE COMPARATIVE LUBRICATING VALUES OP STANDARD AND TECHNICAL WHITE SPINDLE OILS FOR MLES The Joint Committee on Conditions of Work in the Cotton Trade at its 13th Meeting on 23rd April considered the report of Sub-Committee D* Before coming to a conclusion on the recommendations of the report, it was agreed that further tests should he carried out on the lubricating value of the Technical White Oils. Four mills were suggested by the Comnittee as being suitable for the tests. The necessary arrangements were therefore made with these mills and samples of the spindle oils normally used were examined for their viscosity at the Shirley Institute and by the oil company. The two examinations agreed fearly closely and the average viscosities (in centistokes) were as follows;- Mill 1 Mill 2 Mill 3 Mill 4 15.8 18.4 18.1 I8.0 These results are sufficiently close to justify supplying the same Technical White Oil to all four of the mills. The oil supplied had a viscosity of 17.4 centistokes. The power consumption of a mule at each of the four mills was measured first using ordinary spindle oil and, secondly, the Technical White Oil supplied by means of a specially-designed dynamometer fastened to the rim shaft. At each mill the same mile was used for the comparative tests and in each case the miles were run for a period of one to two weeks after changing oils before fresh measurements were made. Plain spindle bearings were fitted on each mule. Particulars of the miles are given in Table I and the results of the power consumption tests in Table II. API 05285 TABLE I PARTICDLAE3 OF KULES JJ"S t of full cop, oz. count Jpijile speed, r. p.m. 1 1032 1* 1.3 22 10,880 ' ? i i 107^ i lg . 1.6 1 22 ; 10,200 3 1092 lS 39 7,920 4 1080 It 1.6 10 8,200 T A B L E II HORSE POWER PER 1,000 SPINDLiS_ in* _ -- Min. _ Kill 2 --- Mill 3 kill 4 Ordinary White_ * Ordinary White Ordinary White iOrdinary White r* ' 30 ; bfi | 1* ! loo i 23.8 , 22.6 j 18.8 17.9 ! 15.6 . 16.1 ! 24.6 15.9 , 21.9 17.4 16.9 16.0 | 22.0 | 17.6 : 16.7 ! 16.1 19.6 14.8 13.4 12.7 20.5 I 20.4 13.6 j 12.9 i 13.8 12.5 ! 13.0 20.4 14.3 13.3 12.7 [15 ! 14.0 , 15.0,, 15.7 ! 15.3 12.4 12.3 ! 12.8 12.6 , `45 ! 24.4 : 13.9 ; 14.7 1 14.6 12.1 12.1 : 12.6 12.5 U i 12.9 ' W.9 14.1 -14.5 11.8 11.7 . 11.9 12.3 '45 i 12.8 ' 13.9 ' 14.1 ` 14.3 11.8 11.4 , 11.7 12,3 5 | 12.8 13-6 14.1 ! 24.3 11.4 11.0 j 11.9 12.2 12.7 . 13.3 14.0 ! 14.2 1 11-3 11.1 . 11.9 11.9 415 i 12.6 : 13.3 14.1 1 14.2 11.4 11.2 ! 11.9 11.9 12.6 13.0 14.1 14.0 11.2 11.2 ! 11.9 11.9 The results for Kills 2, 3 and 4 shoe that the pcnrer consumption was almost identical over a ocmplete morning run for the two oils. The power consumptions at Kill 1 were initially the same hut the white oil led to a slightly higher power consumption after the miles bad been running for a time. This may be caused by the higher viscosity of the white oil over that of the oil normally used at this mill. The results, therefore, lead to the conclusion that the ordinary end the white spindle oils have similar lubricating values. API 05286 REPORT OF TECHNICAL COMMITTEE ON MILE SPINNERS' CANCER jfp. Tbrelkeld, Esq., O.B.E., H.M. Superintending Inspector of Factories, Chairman, Main Committee on Conditions of Work in the Cotton Trade. Sir. (1 ) In July, 1948, an ad hoo joint committee composed of representatives of the Federation of Master Cotton Spinners' Associations, Ltd., the Operative Spinners Amalgamation, the Factory Department, the oil companiee supplying spindle oils, and the Shirley Institute mas constituted with the following terms of reference (i) To consider methods which may he adopted to reduoe the incidence of Mule Spinners' Cancer. (ii) To investigate the qualities of any oils that may he brought to the notioe of the Committee, with particular reference to lubricating efficiency and viscosity. (ill) In particular, to enquire into the suitability of Technical White Oils for use in mile spinning roams in cotton mills. (iv) To consider the comparative coats of any oils found to be satisfactory. (2) After its first meeting, this ad hoo oomnittee was placed upon a permanent and official basis by being reconstituted, in conformity with the recomaend&tion made in April, 1945 by its predecessors, as Sub-Committee D of the main Committee set up to advise on the conditions of work in the cotton trade. (3) Like its predecessors, the committee holds the view that the most certain method of preventing Mule Spinners' Canoer is to restrict oils for lubrication to those which, so far as is known, are non-cancer producing. From the first, therefore, the Casmittee directed its attention particularly to consideration of the use end apeoifioation of the technical white oils which have recently become available to the industry, present infozmation suggests that the cancer-producing components of existing spindle oils ere arom&tio and unaaturated in oharacter. Fortunately, methods have been devised, based largely on treatment with sulphuric M i d , by which, according to the severity of the treatment accorded, greater or lesser proportions of the undesirable components can be removed. (4) It was necessary to establish whether such oils, when sufficiently drastically refined to remove oil detectable quantities of the deleterious components, were still suitable as lubricating agents or whether they ooild be made eo by blending with fatty oils of harmless oharacter. Four mills assigned mules for trials which were carried out under the supervision of the Shirley Institute. The measure of lubricating power adopted was based upon a comparison of the power consumption by the mules under defined conditions with standard spindle oils and with new ones based on technical white oils. At two of the mills the mules were driven by electrio motors and at the others by the mill engine. Two technical white oils were used in the trials, one being a straight mineral oil and the other a compounded oil containing fatty oil to confer additional lubricity. i. API 05287 The results of the tests showed clearly that;- (i) In none of the trials was power consumption greater with the new oils than with standard oils. (11) Although the trials were carried out on moles fitted with plain bearing spindles, no more frequent oiling was necessary with the new oils than with standard oils. /(iii) This in spite of the fact that the new oils were of - slightly lower viscosity than the standard oils. (iv) There was no detectable difference in power consumption between the straight mineral oil end the compounded oil. (6) The Committee therefore decided that technical white oils ire completely satisfactory as mule spindle lubricants and that it is unnecessary to provide additional lubricity by compounding with a fatty oil. The Committee recommends therefore that technical white oils should be used for the oiling of mule spindles, in view of the fact that there is a prim facie case for their non-carcinogenicity and in view of the fact that experiments have shown that their viscosity and lubricating qualities are at least equal to those of spindle oils at present commonly used. (7) The Comaittee, through its sub-conciittee, considered many possible tests which might be used for characterising technical white oils thereby serving as the basis for a specification. Because of their characteristics, the undesirable components impart the colour usually associated with spindle oils and the greater the degree of their removal, the less coloured beoomes the final product. The Committee is of the opinion therefore that although the test for colour given in the Appendix to this Report may appear to some to be too simple to be effective, it is the most conclusive test cf drastic refining which we have been able to accept. It is, for example, so sensitive in the range proposed that the additidn of 0.5 per cent of an ordinary spindle oil to an oil conforming to the Specification would reduce its Saybolt colour from 30 to 25 The Committee reconmends therefore that the oils used for the lubrication of spinning mules should conform to the specification given as an Appendix to this Report. One difficulty which presented itself was that, in practice, it is not uncommon to blend straight mineral oils with fatty oils with the object of improving the lubricity of the former. No reliable test for such a compounded oil has been placed before the Consaittee, which has therefore restricted the specification to the mineral oil. Moreover the tests described above showed no difference in lubricating value between a straight mineral oil and a blended oil. Nevertheless there may be some who would prefer to use a blended oil and the Committee is of the opinion that the addition of up to 10 per cent of suitable fatty oils such as acidleas tallow, lard, . sperm, rapeseed, whale, ground-nut or neatsfcot would present no health hazard and that such an addition may be permitted at the wish and discretion of the purchaser. ' (9) It is emphasised that the mineral oil component will be expected to conform to the Specification for Saybolt colour and the blended oil to the viscosity requirements but the latter can no l o n ^ r be tested against the Specification. The Comittee API 05288 recommends therefore that, so far as possible, users of blended oils should take special care to ensure that they obtain the right kind of oil and that suppliers should facilitate this by supplying the oils in readily identifiable containers preferably under a registered name. (10) The Committee is of the opinion that the introduction of technical white oils is a great step forward in the conquest of Uule Spinners'Cancer and that the adoption of the recommended Specification will, help to ensure their wide adoption in the industry. It regards the whole question as one of great urgency and importance and therefore recommends very strongly tnat appropriate action should be taken to make the Specification as effective as possible at the earliest possible date. (11) The Committee wishes also to endorse the recommendations of their predecessors, first, that there should be periodic medical examinations of all persons engaged in mule spinning and second, that suitable devices to prevent the splashing of oil from mule spindles shall be provided so far as practicable. (12) In the view of the Committee the proposed Specification is severe and more than adequate on the basis of present information to ensure that oils used are innocuous. It is aware that a comprehensive programme of research into the carcinogenicity of mineral oils has been initiated by the Medical Research Council and the Institute of petroleum. It is possible that future investigations may make it desirable to modify the' proposed Specification. The present position is based on the facts as known at this date only. Future improvements are to be hoped for and expected, and as they become available they should be made known to the trade. To this end the Committee recommends that it be kept in being and that the way be left open for a revision of the Specification as and when sufficient evidence to warrant it becomes available. The Committee's recomnendations are:- 1. That Technical White Oils should be used for the oiling of ` mule spindles. 2. That the oils used for the lubrication of mile spindles should conform to the Specification given as an Appendix to this report. ^ 3 That so far as possible users of blended oils should take special core to ensure that they obtain the right kind of oil and that suppliers should facilitate this by supplying the oils in readily identifiable containers preferably under a registered name. A. That appropriate action should be taken to make the Specification as effective as possible at the earliest possible date. 5. That the Coasittee be kept in being and that the way be left open for a revision of the Specification as and when sufficient evidence to warrant it becomes available. API 05289 3 The Cozaaittee wishes to express its appreciation of the valuable services of its Secretory, Mr. Gregson, of the great help which it has received from the representatives of the oil companies and of Mrs. Collier and Miss Mcne for the great care taken in the reporting and preparation of the Minutes of the Committee Meetings. . Gregson, Seeretax7 We are, Sir, Yours faithfully, (Si0Md) SoagUs . B i l l Chairean S .J.I. iu ld , E .S . Bnttereorth, f . Chsmley, Hobert Gregson, C. Hnniher-Beatan, Albert Inowles, W.S.MDen, B. SixTey, CbeSlee Schofield, E.w. Stevenson, J .A . Whitworth API 05290 k. APPENDIX Specification for White Oils for the Lubrication of I&ile Spindles These Oils shall be hydrocarbon oils cf petroleum origin which have been drastically refined with sulphuric acid and which are generally 'understood in the Fetroleujj Industry as "White Oils". They shall meet the following specification:- Colour - Saybolt A.S.T.M. D156-38, (I.F. 18/2*2) not darker than + 30. As an alternative the WQMA instrument nay be used, in which case the colour shall be not darker than W.O.M.A. 3* Viscosity - Centistokes at 140F. 16 - 21. (i.P. J l / W l ) , API 05291 TEXACO DEVELOPMENT CORPORATION lew York 17 V. Y., Marsh 24, 1952 MEDICAL ADVISORY COMMITTEE SUBCOMMITTEE ON CARCINOGENICITY RESEARCH PROJECT ADVISORY COMUTTH Of, M. N. Hewquist Building p#*r Sir: Referring to your lottor of March 20, 1952 enclosing tho iautoa of tho ting of tho above eoanlttee hold in Cincinnati on fibruary 26. I an returning ny ballot approving tho ninutoa. I have oat auggoation, howaror, to mako. In paragraph 6, page 9 it atatoa: it was voted to roquoat tho SubeooadLttoo on Carolnogonieity to initiate pronpt action ainod at adoquato roeorda, ate" Sinoo I wo should not in any way offand tho Suboonalttoo on Nodical Practices, tho action roally vaa to roquoat tho Subooanittoo on Careinogonlclty to roquoat tho Modical Advisory Coaaittoo. Tho Subeoanittoo on Carcinogonieity has no authority over tho vork of tho Subconalttoo on Nodical Praetlcoa. Tho Subcoanlttoo on Carcinegonieity haa ono of two courada to follow - to roquoat tho Nodical Advisory Comittoo to initiate such work through tho Subcoanlttoo on Modical Praetlcoa or to auggeat to tho SubeonaU.tteo that auoh work la alrable. I, personally, such prefer tho directive rather than aggestiyt-Bethod of procedure. Very truly yours, ttM-VRC Attachment Mr. D. V. Stroop S ^ r ^ d : S. 3. M a c kensi K. 0. MACKENZIE API 05292 Xav York 17, I . T . , March 25* 1952 MEDICAI. AOTZSORT COMMIT W E SUBCOMHTSX 01 CAKCZVOOZVZCITT RESEARCH PROJECT APriSORT COMCTTEE Mr. K. 0 Maekansia Building . Daar Siri In eannaetion with your lattar of March 2k$ tha sana objaatira ean ba raaehad by aubnitting tha requaat to tha XubooMittee on Oareinogenlolty and lattili thaa refar it to tha propar eoaalttoa - ria tha Medicai Adriaory Connittee. th Medicai Adriaory Conaittee ean than aaaiga it to tha Madiaal frati.oee Conaittee. In that nannar tha X.F.A Connittaa vili not ba ranning tha ^ole *iow. Tary truly youra, H N. rrEWQUlST, M.D. vtdical dieectoa M. E . IX1QUIST, X. D. nvtm API 05293 April 4, 1952 To: Members of the Special Coordinating Committee Kieffsr Davie, M.D. Kenneth R. Fourcher, M.D. M. K Nevquist, N.D. B B. Reeve, M.D. Centlernen: At the request of Dr. Linder there is enclosed for your information, a copy of letter dated March 25 from w. T. Ounn enclosing report by Mr. William Baden on your meeting of February 27 with representatives of the Division of Refining. Very truly yours. DYS :rd dnc cc - E. K. Linder R. M London API 05294 T A merican P etroleum Institute SO WEST 5 0 T H STREET NEW YORK 2 0 . N. Y. officers 0 z-Oo A T . c h a ir m a n o r r o a r o . * * * % RTER. p r e e io e n y L iF ' n E U - " V l C E .r R .S I O .N T ftVrtWAARTT.*JJ RB"- V I C E .r R l I D H T ,1. *"7 KENNEDY. V I C . .P R E S I D EN T '> 7 HCER* v ic e -PPRR ESID E N T f f t ^ T E R JE N N IN G S . TREASURER F YT L" ' K ER , SsEeCcYy ., Aa Nn O. A S S T . T R E A S . ^r^ilTTEE JR ~ C H A IR M A IN ( U, > . V .C ...C H A IR M A N J (JAY. s e c r e t a r y March 25, 1952 DIVISION O F REFINING W . T. GUNN, s o o c m LE ` ,, IN 1* F *00*'" P ^ f , BOWLES ^ H. SURRUS F T I bthaus To the Members of the General Committee, Division of Refining. i**id*oh " `SB1* , n R * rtBSUSON w | A FIMER ..HANCOCK jiH O J J N O rngter r^LANCMTT ITOC 0 KW MAN Lu fo r tun e [lJ* t. button lynch . MACHRtS LiA*U D ER lhartin ^ accr ; CONNELL . curry r t HILLER [. HOORI naden W. NEW TO N C. N IE L S O N . OSBORN *fc PAULSEN l PAULUS . PPARR ..OSSIE ilO S C R S O N U.MU llR tE R W O O O ' ONORBOOER O N N E S O R N , IH STROUD RIUJVAN ltati ` 4 HT1W ORTH * * *AYER [*`t ? u r r T *AI DEN * WERTX ^W ILLIA M S ^OQOW ARD 1 RYNN 8 **MR N Gentlemen: Enclosed Is copy of a report by Mr. W i l l i a m Naden, d a t e d March 11, 1952, on a m e e t i n g held F e b r u a r y 27, 1952, b e t w e e n representatives of the Division of Refining and representatives of the Medical Advisory Committee, Department of Safety. This matter will be on the agenda of the meeting of the General Committee in San Francisco, M a y 15* 1952. Y o u r a t t e n t i o n is c a l l e d to Mr. N a d e n 1s recommendation "that consideration should be given to having a permanent c o m m i t t e e . . .to advise the General Committee regarding the actions taken and recommendations made by the Medical Advisory Committee." Yours very truly, WTG:ms Enclosure API 05295 COPY ESSO STANDARD OIL COMPANY 15 West 51st Street N e w Y o r k 19* N. Y. March 11, 1952 Hr. W. L. S t e w a r t , Jr., V i c e - P r e s i d e n t American P e t r o l e u m I n s t i t u t e 50 W e s t 5 0 t h S t r e e t New Y o r k 20, N. Y. Dear Mr. S t e w a r t : In accordance with your instructions, as outlined in Mr. W. T. G u n n ' s l e t t e r of F e b r u a r y 14th, the C o o r d i n a t i n g Committee which you appointed met with a Subcommittee of the Medical Advisory Committee at the Netherlands Plaza Hotel, Cincinnati, Ohio, on February 27, 1952. The following were in attendance: Special Coordinating Committee of the Division of Refining W. R. A r g y l e ................................ S i n c l a i r R e f i n i n g Co. Dr. L. B. B e a r d , f o r C. S. T e i t s w o r t h . . S o c o n y - V a c u u m O i l Co., Inc. F. H. Hol m e s , f o r M. H a l p e r n ............ T h e T e x a s C o m p a n y D. R. J o h n s o n , f o r H. G. O s b o r n ......... C o n t i n e n t a l Oil Co. W. J. M c G i l l , f o r M. G. P a u l u s .......... s t a n d a r d Oil Co. (Indiana) Wm. N a d e n .................................... E s s o S t a n d a r d O i l Co. Subcommittee of Medical Advisory Committee K i e f f e r Davis, M . D ..... ................... P h i l l i p s P e t r o l e u m Co. K e n n e t h R. F o u r c h e r , M . D ................. S t a n d a r d Oil Co. (N.J.) E. K. L i n d e r , M . D ........................... T h e A t l a n t i c R e f i n i n g Co. M. W. N e w q u i s t , M . D ........................ The T e x a s C o m p a n y B. B. R e e v e , M . D ............................ S t a n d a r d Oil Co. (Indiana) R. M. L andon, r e p r e s e n t i n g J a m e s W. Long, M . D ................. G u l f O i l G r o u p At the start of our meeting there were some discussions as to the duties of the two R e f i n i n g D i v i s i o n com m i t t e e s that were recently appointed to meet with the Subcommittee of the Medical Advisory Committee -- the above committee and also the c o m m i t t e e u n d e r t h e c h a i r m a n s h i p of Mr. T. J. S u l l i v a n . It wa s finally felt that Mr. Sullivan's committee was appointed to review the work of the Medical Advisory Committee, but that our API 05296 J4J., w. L. Stewart, Jr -2- March 11, 1952 committee was appointed "to determine whether or not a mechanism can be worked out w h ereby the Medical Advisory Committee can be furnished direct assistance and advice of qualified refiners." In our discussion we reviewed the makeup of the Medical Advisory Committee which is composed of medical doctors from the member companies, together with a comparable number of associate or technical advisors. It was established that the work of the Medical Advisory Committee is to make recommendations as to m e d i c a l p r o b l e m s a n d p o l i c i e s as t h e y p e r t a i n to the petroleum industry and that decisions regarding the recommenda tions to be made is the sole responsibility of the fully a c c r e d ited members (M.D.s) of/the Medical Advisory Committee. Associates have been available to the committee to give advice on matters pertinent to refining and such technical advisors have always had representation on the subcommittees of the Medical Advisory Committee. After a thorough review and discussions of the workings of the M e d i c a l A d v i s o r y C o m m i t t e e a n d its s u b c o m m i t t e e s t o gether with the associate members or technical advisors, it was unani mously agreed that a mechanism already exists to furnish qualified assistance and advice on problems that pertain to the Refining Division. It was felt that if the m e mber companies continue to nominate competent technical advisors to this committee that there would be no need for any further assistance. Although it might not have been pertinent to the subject we were commissioned to deal with, your committee did express the thought that consideration should be given to having a permanent committee, such as the committee now working under Mr. T. J. S u l l i v a n , to r e v i e w t h e w o r k of the M e d i c a l A d v i s o r y Committee, and to advise the General Committee on Refining regarding the actions taken and recommendations made by the Medical Advisory Committee. At the close of the meeting the group accepted an invitation to visit with Dr. Kehoe and his associates at the Kettering Laboratory where we were privileged to witness the work in progress that is going on for A.P.I., as well as work going on for other industries. We not only found it extremely interesting but were very favorably impressed with Dr. Kehoe and his associates. We were impressed with the fact of his long association with industry problems in general, and we all felt that he is eminently qualified to handle the medical research projects that have been assigned to the Kettering Laboratory by the A.P.I. API 05297 jjj., w. L. Stewart, Jr. -3- March 11, 1952 I trust you will accept the above as a report of the Special C o o r d i n a t i n g C o m m i t t e e . Sincerely, / s / Wm. Naden WN:m cc - Mr. W. R. A r g y l e - S i n c l a i r R e f i n i n g Co. Mr. W. T. G u n n - D i v i s i o n of Refining, A.P.I. Mr. M. H a l p e r n , Att. Mr. P. H. H o l m e s - T h e T e x a s Co. Mr. H. G. Osborn, Att. Mr. D. R. J o h n s o n - C o n t i n e n t a l Oil Co, Mr. M. G. Paulus, Att. Mr. W. J. M c G i l l - S t a n d a r d Oil Co. (Indiana) Mr. C. S. T e i t s w o r t h , Att. Dr. L. C. B e a r d - S o c o n y - V a c u u m Oil Co., Inc. I API 05298 ) American petroleum institute 50 W EST 50th STREET NEW YORK 20. N Y. T of t e c h n i c a l s e r v i c e s v. S T R O O F . DIRECTOR April 7 , 1952 To: Members and Associates . Medical Advisory Committee Gentlemen: For your information and future reference we enclose c o p y of m e m o r a n d u m f r o m D o c t o r R a y m o n d R. S u s k i n d , outlining the skin physiology project at Kettering Laboratory. Our contribution of $2,500 for the six-months period ending June 30, 1952 has been sent to Dr. K e h o e . ( Very truly yours, DVS:rd Enc. API 05299 ) RESEARCH PROGRAM SKIN PHYSIOLOGY PROJECT KETTERING LABORATORY, UNIVERSITY OF CINCINNATI 1952 Background and Purpose f The concept of the skin physiology project at the Kettering . moratory is a natural outgrowth of the increasing demand for infor- 2 ti0n about m e d i c a l p r o b l e m s , i n d u s t r i a l a n d n o n - i n d u s t r i a l , in w h i c h j:in f u n c t ion is a n i m p o r t a n t fac t o r . The establishment of this roJect is an to satisfy a pressing need for well established cientific knowledge about the c h e m i s t r y and p h y s i o l o g y o f n o r m a l skin *. well as s k i n in a b n o r m a l e n v i r o n m e n t s . Since the inception of the *-oject, the f i e l d of s k i n c h e m i s t r y a n d p h y s i o l o g y h a s b e e n e x p l o r e d \ Q ascertain not only what specific problems might be effectively a t ta c k e d , but what techniques of study require development to facili ta te an orderly approach to these separate problems. During this period, too, the original program of the project W s undergone a process of natural maturation which was characterized by expansion a n d the g r a d u a l i n c l u s i o n o f n e w p r o b l e m s in the i n v e s t i gative p r o g ram. The latter has been possible only with an increase m trained personnel and research facilities. It has been necessary, therefore, to m e e t the e x p a n d i n g b u d g e t a r y r e q u i r e m e n t s of this p r o ject. II. Speci f i c R e s e a r c h P r o b l e m s The following is an outline in brief of skin problems which have b e e n o r a r e u n d e r i n v e s t i g a t i o n . A. S e b a c e o u s G l a n d C h e m i s t r y 1. T h e i d e n t i f i c a t i o n a n d l o c a l i z a t i o n o f l i p i d s a n d enzymes and other chemical constituents of the sebaceous gland and their secretions in normal and diseased states. 2. The q u a n t i t a t i v e s t u d y of p i l o s e b a c e o u s c o n s t i t u e n t s in normal and diseased skin. 3. A q u a n t i t a t i v e s t u d y of l i p i d s i n v a r i o u s l e v e l s of the skin. The observations which were made on the lipids and enzymes by histochemical methods are now being verified and enlarged by the study of normal and API 05300 - 2 abnormal sebaceous material employing micro chemical techniques. The particular interest of the group is to ascertain the normal chemical constituents of human sebum, the locale of their development and change, and the chemical alterations which occur in diseases of the pilosebaceous appa ratus such as acne vulgaris, occupational acne and keratin cysts. A systematic study of the metabo lism and function of the sebaceous glands is closely linked with the project's interest in percutaneous absorption since the pilosebaceous unit is probably the most important portal of entry for non-gaseous, noxious substances which pass through or into the intact skin. The following is a list of publications of the group in connection with its sebaceous gland study: 1. S u s k i n d , R.R.: T h e c h e m i s t r y of the h u m a n s e b a c e o u s g l a n d . I. H i s t o c h e m i c a l o b s e r v a t i o n s . J. I n v e s t . D e r m a t . 17: 3 7 - 5 ^ , 1 9 5 1 2. S c h m i d t - N i e l s e n , K., S u s k i n d , R.R. a n d Taylor, E.: The chemistry of the human sebaceous gland. II. Analysis of human sebaceous m a t e r i a l f r o m i n d i v i d u a l ori f i c e s . J. Invest. Dermat. 17: 281-290, 1951. 3. S c h m i d t - N i e l s e n , K. a n d T a y l o r , E.: U s e o f a quartz fiber micro balance for histochemical investigations of skin. J. Inv e s t . Dermat. (in p r e s s ) . B. Percutaneous Absorption 1. T h e s t u d y o f f a c t o r s w h i c h i n f l u e n c e a b s o r p t i o n through animal skin. 2. T h e a p p l i c a t i o n of r a d i o i s o t o p e s to the s t u d y of skin absorption problems. This includes route of penetration as well as the rate of absorption. 3. T h e k n o w l e d g e a n d e x p e r i e n c e of the g r o u p w i t h respect to absorption is employed in a practical fashion in problems of industrial hygiene. It is consulted by industry and other interested groups on such matters as cutaneous protective measures with relation to irritants, sensitizers, acnegenic and carcinogenic materials. API 05301 > - 3- C. C u t a n e o u s I r r i t a t i o n a n d S e n s i t i z a t i o n 1. T h e s t u d y of p h y s i o l o g i c a l , c h e m i c a l a n d b i o l o g i c a l f a c t o r s w h i c h i n f l u e n c e i r r i t a t i o n sind s e n s i t i z a t i o n . Problems which have been assailed and currently being studied are: (a) The i n f l u e n c e of the e n d o c r i n e s on c u t a n e o u s irritation and sensitisation. (b) The influ e n c e of p e r c u t a n e o u s a b s o r p t i o n on irritation and sensitization. 2. The d e v e l o p m e n t a n d i m p r o v e m e n t of t e c h n i q u e s to measure the irritant and sensitizing capacity of chemical compounds. This includes both human and animal methods of evaluation (See E below). The following are the publications in connection with the cutaneous irritation and sensitization studies: 1. N i l z e n , A.: S o m e e n d o c r i n e a s p e c t s o f s k i n sensitization and primary irritation. J. Invest. Derm a t . 18: 7-35 1952. 2. N i l z e n , A.: S o m e a s p e c t s o f e p i d e r m a l t e s t i n g of guinea pigs sensitized and not sensitized t o 2, 4 - D i n i t r o c h l o r b e n z e n e . F o r Dr. H. Haxthausen's "Festschrifte" to be issued October 1952. D. P a r t i c i p a t i o n in the A . P . I , P r o j e c t on C a r c i n o g e n i c i t y Several problems which have arisen in the A.P.I. project require and will continue to require the cooperation and a d vice of the members of the skin physiology group and their participation in the A.P.I. program. These problems include: 1. T h e r o l e o f p e r c u t a n e o u s a b s o r p t i o n a n d p r i m a r y irritation on experimental tumor rates. 2. T h e role of c o c a r c i n o g e n i c i t y in sk i n p a i n t i n g experiments. 3. T h e e f f e c t o f b a r r i e r c r e a m s a n d w a s h i n g on e x p e r i mental tumor induction. E. The Use of Cutaneous T echniques in Problems of Industrial Toxicology ---- The personnel of this project in cooperation with the other d ivisions of the labo r a t o r y are f r e q u e n t l y c a lled upon to delve into matters of industrial hygiene at a fundamental or API 05302 i -4 - testing level when the skin is a potential or prominent factor in the exposure. The group is organized: 1. T o e v a l u a t e i n d u s t r i a l a n d c o n s u m e r m a t e r i a l s f o r potential cutaneous irritancy, sensitizing capacity, percutaneous toxicity, acnegenic properties, etc. 2. T o i n v e s t i g a t e c l i n i c a l I n d u s t r i a l p r o b l e m s w h e n they may arise by surveying the plant or industry and studying the problems involved at a laboratory or clinical level. The facilities available are particularly helpful in the study of such practical problems. _ Ill- Personnel In its present form the program's activities are being carried oUt under the d i r e c t i o n o f Dr. R a y m o n d R. Suskind. Dr. Knut Schmidt- jielsen, a p h y s i o l o g i s t , is in c h a r g e o f the m i c r o c h e m i c a l a n d r a d i oisotope p e r c u t a n e o u s a b s o r p t i o n s t u d i e s . The other members of the staff i n c lude a c h e m i c a l e n g i n e e r w h o is i n char g e of the iso t o p e laboratory, a t e c h n i c i a n in the isotope laboratory, a full time a s sistant f o r m i c r o c h e m i c a l w o r k a n d a f u l l t ime t e c h n i c i a n f o r h i s t o - cheoical, c u t a n e o u s i r r i t a t i o n a n d s e n s i t i z a t i o n s tudies. IV. F a c i l i t i e s The facilities allocated to the work of the project include a well-equipped histological and histochemical laboratory, an analytical laboratory especially designed for microchemical work, a constant temperature room in which a wide range of atmospheric conditions may be produced, a r a d i o i s o t o p e l a b o r a t o r y , a n d a n i m a l q u a r t e r s f o r b r e e d ing a h y p e r s e n s i t i v e s t r a i n of g u i n e a p i g a n d f o r h o u s i n g a n i m a l s on cutaneous experiments. The*facilities and services of the other de partments of the Kettering Laboratory have been effectively integrated into the w o r k o f the p r o j e c t as the p a r t i c u l a r n e e d s have arisen. V. F i n a n c e s The financial sponsorship of the skin physiology project was initially undertaken completely in 1948 by the Bristol-Myers Company which a l l o c a t e d funds for a three y e a r period. tributed $20,000 per year from 1948-1951. The sponsor con Until recently the original endowment satisfied the needs of the p r o g r a m. With the normal development and growth of the project, the g e n e r a l I n c r e a s e in e q u i p m e n t c o s t s a n d s a l a r i e s , the e c o n o m i c requirements of the full program are now several times the amount of the p r o j e c t as o r i g i n a l l y p l a n n e d . API 05303 i - 5- As of October 1950# a grant of $10,000 per year was initiated th e Procter and Gamble Company in partial support of the irritation ^ sensitization studies. This endowment continues. Several months t h e Monsanto Chemical Company contributed $5,000 towards the g e n support of the project during the year 1951. Monsanto has efL an a d d i t i o n a l c o n t r i b u t i o n o f $ 3 , 0 0 0 f o r the y e a r 1952. Addi- "fonal saunpn po o r t is a v a i l a b l e u n d e r the t e r m s o f a cr.oontt-raarc.it. w i t h the ! ited S t a t e s A i r F o r c e f o r the w o r k on p e r c u t a n e o u s a b s o r p t i o n of riauid o r g a n i c c o m p o u n d s . T h i s w i l l p r o b a b l y n o t e x c e e d the sum of l11?0.00n0o imn 1iQ9s5;2o. a f u r t h e r g r a n t of $ 3 ,0 0 0 h a s b e e n m a d e f o r the -ear 1952 by the A b b o t t L a b o r a t o r i e s . Two other pharmaceutical compa nies have e x p r e s s e d i n t e r e s t r e c e n t l y i n the s u p p o r t o f the p r o g r a m . funds made available so far towards this work have been without strings e x c e p t in the case o f the A i r F o r c e in w h i c h i n s t a n c e t hey are earmarked for w o r k in the a b s o r p t i o n s e c t i o n of the program. A tabulation below summarizes the situation with respect to funds n o w a v a i l a b l e f o r 1 9 5 2 i n c l u d i n g t h a t r e p r e s e n t e d in the r e c e n t # commendation of the A.P.I. Medical Advisory Committee. Sponsors Monsanto Chemical Company Abbott Laboratories . S. A i r F o r c e ( a p p r o x i m a t e l y ) Procter and Gamble Company Amounts $ 3, 000.00 3 , 000.00 1 0 ,0 0 0 . 0 0 1 0 ,0 0 0 . 0 0 A. P. I. Total 5,000.00 $31, 000.00 The total sum shown above is not sufficient to support the e n tire p r o g r a m w h i c h w e h a v e in m i n d , a n d it a l l o w s n o t h i n g f o r f u t u r e development, but it is hoped and believed that additional sums can be obtained. M e a n w h i l e the w o r k w i l l be r e t a r d e d s o m e w h a t to fit the funds a v a i l a b l e . API 05304 N e w York, N. Y., A p r i l 9, 1952 To Members and Associates Subcommittee on Carcinogenicity Gentlemen: For your information I am enclosing a copy of Dr. R o b e r t A. K e h o e *s l e t t e r o f M a r c h ij., 1952, w h i c h gives his estimate of the b u d g e t a r y r e q u i r e m e n t s to carry on the resea r c h p r o g r a m on carcinogenicity of petroleum and petroleum products for one year beginning July 1,1952. Very truly yours, M. N. N E W O U I S T , M. D. Chairman, Subcommittee on Carcinogenicity MNN.-RMS ENC . me: Members and Associates Medical Advisory Committee Mr. D. V. Stroop Dr. R. A. Kehoe API 05305 * UNIVERSITY 0? CINCINNATI C .0 ? Y Department of Preventive Medicine and Industrial Hsalth Kettering L a b o r a t o r y "-ile^e of M e d i c i n e - E d e n -inci^n a t ^ 19 Ohio Avenue M a r c h 4, 1 9 5 2 Mr. D. V. S t r o o p American P e t r o l e u m Institute 50 '.Vest 5 0 t h S t r e e t New Y o r k C i t y 2 0 Dear Mr. Stroop: At the last meeting of the special Committee with us on F e b r u a r y 26, it was su g g e s t e d that the budget for the next y e a r be revised in its manner of presentation. I have done this in a w a y that is p r o b a b l y more complete than is necessary. In a n y case, it is illustrative of the facts as to w h a t we s p e n d m o n e y for, and I b e l i e v e that no one is likely to conclude that our "overhead" is h i g h l y excessive. If this suits y o u r purposes, it can oe sent out in this form. If y o u think it b e t t e r to e x p r e s s the same figures in a n o t h e r way, I 'll be g l a d to f o l l o w y o u r s u g g e s t i o n s . With best regards, Sincerely yours, RAK/ef / s / R o b e r t A. K e h o e R o b e r t A. Kehoe, M.D. API 05306 COPY BUDGET DATA FOR AMERICAN PETROLEUM INSTITUTE Investigation of Cutaneous Carcinogenic Materials by The Kettering Laboratory Estimated b u d g e t f r o m July 1, 1952 to July 1, 1953 mirroensation for Personnel Supervision Chemical technology Principal investigator Research chemists Total $ 8 ,000.00 12,500.00 Biological Testing Gross pathology and records Microscopic pathology Technicians (animal tests) Post-mortem examinations Preparation for microscopic slides Total 2 ,600.00 2 ,200.00 3,700.00 1 ,200.00 3,600.00 Epidemiology Principal investigator Total 5,000.00 Other personnel (Indirect) Administration (General administration, accounting, etc.) 4,600.00 Other 15,900.00 Secretarial and clerical Library Animal care Glass-ware washing Draughting Janitor and sundry Total Total Compensation for Personnel $ 5 f 00000 20,500.00 13,300.00 5,000.00 20.550.00 64,350.00 Miscellaneous Expense Scientific supplies General supplies and replace ments Annuities and pensions Travel Animals and food Maintenance, heat, light, power, telephone service 7.00. 00 5.620.00 4.260.00 5.000. 00 4.600.00 API 05307 5.700.00 1 - 2- Stationery, postage, office supplies, and medical art 3 1,070.00 Educational expense, develop ment work and periodicals 7,160.00 Total Miscellaneous Expense Total estimated expenditures 40.410.00 104,760.00 API 05308 A merican P etroleum Institute 5 0 W EST SOTH STREET NEW YORK 2 0 . N. Y. April 30, 1952 Xr. T. <J. Sullivan., Vice President Gulf Cil Corporation p.O. Bex 1166 Pittsburgh 30, Pennsylvania Epidemiological Survey Subcommittee on Carcino genicity Medical Advisory Committee __________ API_____________ Gear Mr. Sullivan: I am enclosing a progress report of the activities of the Subcommittees on Carcinogenicity of the Medical Advisory Conmittee, API. Inasmuch as Mr. G. A. Davidson plans to present the report to the General Committee of the Division of defining in your absence, I am taking the liberty of sending 65 mimeographed copies directly to Mr. Davidson. In connection with the study of the carcinogenicity of petroleum and petroleum products, our subcommittee considered originally that an epidemiological study should consist of two parts: (1) the study of the incidence of cancer among employees of the petroleum industry and, (2) the study of cases of cancer (mostly skin cancers) among employees of customers where the cancer was allegedly due to exposure to petroleum products. Item one is already underway. Item two is so Involved that we have done nothing about it. We have, of course, been alerted by recent verbal reports of alleged skin cancer cases occurring among customer employees but we believe this situation should have the careful consideration of the Divisions of API which would be concerned. Your advice in this connection would be greatly appreciated by our Subcommittee. Very truly yours, /s/ M. N. Newquist M. N. NEWQUIST, Chairman Subcommittee on Carcinogenicity MNN :EM5 Copies: M r . G. A. Davidson - Standard oil of California Mr. H. W. Ferguson - Humble Cil and defining Company Mr. J. P. Lungfitt - The Pure Oil Company Mr. W. T. Gunn - API API Members and Associates, Medical Advisory Committee, API 05309 0 Sullivan Hf 0 President % Cil Corporation ^ g t u r g d 3C, Pennsylvania 135 E. 42nd. Street New York 17, N. Y. April 30, 1952 Subconmittee on Carcinogenicity Medical Advisory Committee ___________ A P I ______________ :ear Sir: This resume prepared by the Research Project (MG-1) Advisory -MB&ittee in accordance with your request of February 13, 1952, suinoarizes -e activities of the Subcommittee on Carcinogenicity of the Medical Advisory jancittee API. Experimental evidence on mice was developed about 1943 by Dr. E. V. Covcry at the Barnard Hospital, St. Louis, attributing carcinogenic properties to residua from catalytic cracking. Late in 1944 Dr. R. E. Wilson called jttention to the desirability of investigating any possible cancer hazards vnich might arise from newer refining processes. These were the chief factors leading to the organization in 1945 of the API Medical Advisory Committee. At its first meeting in May 1945, this committee, among other things, recamended a study of the possible carcinogenic properties of petroleum and petroleum products. This recommendation was approved by the Executive remittee of the Board of Directors of the API and a fund of $25,000 was authorized to initiate this and other medical studies. After careful consideration Kettering Laboratory, University of -iixirnati, was selected to make an initial study of the problem. A grant $6,COO was made February 1, 1946, to conduct a limited amount of animal API 05310 testing on eight samples of high boiling fractions selected by the Subcommittee 'n carcir-ogenicity. The results of this study completed in 1948 showed that :igh boiling gas oils from catalytic cracking produced skin cancers on ?6peated application to mice. This finding led to the formulation of a program of research at Kettering Laboratory. This program .gsitated a capital grant to Kettering Laboratory of $40,000 for the oc .0p5truction of animal quarters. (See attached list of expenditures.) The f p&ni e i research program got under way late in 1949. ^ rrcTIVZS - The research program includes the following primary objectives: 1. The determination of which refinery streams and products are carcinogenic and to identify if possible the causative agents in such streams and products. 2 . Development of reliable analytical techniques for quick and inexpensive determination of the carcinogenic potency of any stream or product. 3. Investigation of protective measures which might be applicable to man. 4. Epidemiological studies to determine the incidence of cancer among employees of the petroleum industry as compared to the general population. PROGRESS TOWARDS ACCOMPLISHING THE OBJECTIVES 1. Identification of carcinogenic streams or products and causative agents. To date 110 different petroleum fractions from representative processes have been tested on mice. Fractions of four different crudes are also being studied. Products of catalytic cracking and thermal cracking of catalytic gas oils have been sampled fairly completely. Vacuum distillates including lube stocks are also under study. A sufficient variety of samples is on hand to consummate this phase of the program. It has been demonstrated that seme carcinogens exist in the criminal crude oils and that certain refinery processing of oils concentrates iad/cr synthesizes carcinogenic materials. High boiling gas oils from catalytic API 05311 -3- I -nc have continued to show relatively high carcinogenic potency to nice. I .rSC*11* ^ clacking of high potency catalytically cracked residua does not reduce pr0y. Furthermore, high.boiling gas oils produced in severe thermal ?c " * M-.a of straight run residua have demonstrated high potency. Untreated 'Stillates show low to moderate carcinogenicity to mice. i>-e " Polycylic aromatics which fall into the general classes of r,,,,(c) phenanthrene, benzpyrene and benzanthracene have been identified rically in carcinogenic oils. Certain compounds in these classes have been for years to be carcinogenic to mice. The ratios of these classes of C-- * * capounds or of individual carcinogens vary in oils depending upon their source subsequent processing. Complicating the picture is the presence of aerials which in themselves are not careinogenic, tut which have the ability to enhance the potency of carcinogens in these oils. 2. Analytical Tool - Many of the pure polycyclic compounds with d?vn carcinogenic activity have an identifiable absorption spectrum in certain :arcs of the ultra-violet and visible range. This knowledge has been used as s.e basis for developing an analytical tool. Empiric correlations of biological I iata with absorption spectra have not thus far been entirely satisfactory, in jar: due to the non-quantitative nature of the biological tests and in part due expounds whose chemical or physical properties influence carcinogenicity, but io not exhibit a characteristic absorption spectrum. The first of these factors has necessitated a program adjustment to study the basic fundamentals which lead to a quantitative biological test. second factor has led to a study of those chemical and physical properties *bich influence the carcinogenicity of an oil such as solvents, viscosity and ""dancing compounds. Obviously the intricate nature of the problem of develop- **3 an accurate analytical tool plus the identification of the causative agents ' . sufficiently broad classes to permit evaluation of carcinogenic refinery API 05312 -k- will require more time and effort than originally anticipated. Without tr*38 -lytical tool, any laboratory proof of carcinogenicity rests upon animal & ' ting which is expensive and time-consuming (three to twelve months required ^ 5?xh test on mice). . 3. Preventive Measures - Animal experimentation and practical rience in industry where occupational cancer hazards have existed indicate ?XF z this hazard can he controlled by minimizing exposure and by adequate JgldA-'eal supervision which will include periodic physical examinations. Minimizing exposure entails: a. Identifying the sources of exposure. b. Informing the persons who may be exposed, of the hazard involved and of preventive measures. c. Providing of protective equipment or facilities where exposure is otherwise unavoidable. d. Good personal cleanliness. Shin cancer if detected early is curable. An adequate medical program will insure early detection. k . Epidemiological Survey - It is not possible to transfer directly tho data from the mouse testing experiments into figures representing relative carcinogenicity of the various fractions for man. From a scientific standpoint it would be desirable to test carcinogenic potency on several higher species of animals including man. However, such testing is not feasible at the present time. Interpretation of the significance of the experimental data, therefore, must await procurement of data on human cases from epidemiological surveys. An epidemiological survey will develop the facte concerning the incidence of cancer among petroleum workers and, if correlated with the occupational history, should disclose whether any particular occupation in the petroleum industry is associated with an occupational cancer hazard. In addition, it will detect any API 05313 -5- t ,, e i s e in cancers which may be the result of failure of protective measures. without such information a problem of major magnitude could develop undetected jnd protection of the petroleum industry from unsubstantiated claims for ,,Mipensation for alleged occupational cancer would be almost impossible. This *>ta98 f the Prosram must be continued for a number of years in order to be of This study is now underway and the annual cost is low. INCLUSION - Occupational cancers comprise a very small percentage of the total 'Ui'cer of cancers. However, experience in the British coal tar industry where :ver 1,^00 cases of skin cancer were diagnosed in a 20-year period, and experience from contact with British shale oil where over 1,500 cases of skin cancer were diagnosed in a similar period, indicate that a cancer hazard may assume a serious magnitude in industry before control measures are instituted. British statistics are probably more accurate than those in the United States because reporting of cases to the Government is required and enforced. Medical literature and unpublished reports both in this country and abroad incriminate certain petroleum products which, having been demonstrated on animals to have a low degree of carcinogenicity, have caused human skin cancers after exposure of many years duration. The importance of such observations to the petroleum industry emphasizes the necessity of a continuing program to develop the facts as well as to promote any precautionary measures that may be indicated. In this connection certain petroleum companies in the United States have already instituted precautionary measures within their own organizations. In Great Britain it is now mandatory that white lubricating oil be used in one phase cf textile manufacturing. It is planned that the research project (MC-1) at Kettering laboratory will proceed along lines of the objectives set forth above. Such API 05314 6- earch activities have now reached the peak and it is expected that there r*3 >e a gradual decline in a year cr two from now unless unfcrseen situations in the interim. jrise This committee will he pleased to render any further progress .ts which you may desire. rsP: Submitted on behalf of the committee by /s/ M. N. Newquist Chairman yeobers of Research Project (MC-1) Advisory Connittee. y_ n . riewquist, M.D., Chairman r W. Adams c. Beard, Jr. leffer Davis, M.D. 3, 2 . Zckardt, M.D. M. Frank, M.D. C. E. Hine, M.D. 3. M. Landon K. Linder, M.D. . G. Mackenzie 2. C. Mithoff 3. M. Shepardson The Texas Company Standard Oil Co. (Indiana) Socony-Vacuum Oil Co., Inc. Phillips Petroleum Co. Standard Oil Development Co. Pan American Refining Corp. Shell Development Co. Gulf Oil Corporation The Atlantic Refining Co. The Texas Company California Research Corp. Standard Cil Development Co. (N.J.) (N.J.) API 05315 PAYMENTS BY API 2 -l-k 6 7-I-U6 1-1-U7 ' 7-l-*7 1-1 -he 7-1 - w l-l-^9 7 -I-U9 1-1-50 7-1-50 ' 1-1-51 7-1-51 1 -1-52 UNIVERSITY OF CINCINNATI for RESEARCH PROJECT (MC-1) CN CARCINOGENICITY $ 6,000.00 0 0 0 0 65,000.00 (includes $Uo,OCC grant for animal quarters) 0 *9,^13.00 . 39,963.39 50,000.00 9 ,0 6 5 .1 2 50,000.00 31,692.42 $ 301,133.93 to June 30, 1952 Budget July 1, 1952, to June 30, 1953 $ 10^,760.00 API 05316 THE TEXAS COMPANY 1 3 9 EAST 4 2 n d STREET NEW YORK 17. N. Y April 30, 1951 p, T. J. Sullivan, Vlaa President golf 311 Corporation f. o. Bex 1166 Pittsburgh 30, Pennsylvania genialty Hedlaal Advisory Count ttaa pear Hr. Sullivan t I am snsloaLng a prepress report af tbe astivltlai of the lubaonaittaaa on Carelnogenlslty of tta Hadiaal Advisory Canittee, API. Inasmash as Hr. 0. A. Davidson plana to present the report la the Oeasral Coanittee oi the Division of Jteflning in your absence, I an taking the liberty of sanding 65 aineegraphed aeplas iireotly to Nr. Davidson In soonestion aith the study of the earelaogonielty of patroloun and petreloun produeta, our subseon!ties aonsidered originalIt that an opldeniolegisal study should sonslst of toe partet (1 ) the study of the lnoidenee of aaneer anang o^leyeea of the petreloun industry aid, (2) the study of oases of earner (neatly akin aaneera) aneng employees ef oastanora here the aaneer ms allegedly due te ezpeaure te petreloun produote. Xteu one is already undoreay. Iton tee la oe invelyed that ee have dene nothing about it. Vo have, ef sourso. Won alerted by resent verbal roperts of alleged akin esneer eases eeearring anang austoner teployeea bet ee believe this situation jd&euld have the eareful eenaideratiea ef hie Divisions of API ahleh oonld be eoneemed. Tour advloo in this eeuaeetlen eeuld be greatly appreeiated by our lub- fary truly yeure on Caroinogoalaity nxtRki Coplea i r. a. A. Davidson - standard oil of California lb% H. v. Ferguson - Humble Oil and Bofining Qoupeay lr. J. P. Langfitt - The Pure Oil Coapaoy h . v. T. O m m API lanbore and Associates, Hadiaal dvlsory Cooed.tteo, API API 05318 1 S. 42nd street l e v Y o r k 17, W. T. April 30, 1952 f# j. S u l l i v a n president oil c o r p o r a t i o n ^ . b u r i * 30, Pennsylvania iv > * ' i f Sirs Subcommittee on Carcinogenicity Medical Advisory Committee ___________ ____ A P I __________________ This resume prepared by the Research Projest (MC-1) Advisory got Ittee in a ccordance w i t h your request of F e b r u a r y 13, 1952, irises the activities of the Subcommittee on Carcinogenicity of fill**' jj,# Medical A d v i s o r y C o m m i t t e e API* Experimental evidence on mice was developed about 1943 by jf, 3. V. C o w d r y at the B a r n a r d H o a p i t a l , St. L o u i s , a t t r i b u t i n g ureinosanic properties to residua from catalytic cracking. Late in 944 Dr. R. . W i l s o n c a l l e d a t t e n t i o n to the d e s i r a b i l i t y of i n v e s tigating a n y p o s s i b l e c a n c e r h a z a r d s w h i c h a i ' u t a r i s e f r o m n e w e r ^fining processes. These were the chief factors leading to the or ganization in 1345 of the A P I M e d i c a l A d v i s o r y Committee. At its f i r s t meting in May, 1345, this committee, a m o n g other things, recommended i study of the p o s s i b l e c a r c i n o g e n i c p r o p e r t i s s of p e t r o l e u m and pstroleum products. This r e c o m m e n d a t i o n was a p p r o 7 ad b y the Executive Comalttae of the B o a r d of Dir e o t o r s of the A P I and a f u n d of $25,000 tts a u t h o r i z e d to i n i t i a t e t h i s a n d o t h e r m e d i c a l s t u d i e s . After careful consideration lettering Laboratory, University f C i n c i n n a t i , w a s s e l e c t e d to m a k e a n I n i t i a l s t u d y o f the p r o b l e m . A grant of $ 6 , 0 0 0 w a s m a d e F e b r u a r y 1, 1946, to c o n d u c t a l i m i t e d API 05319 uount of animal testing on eight samples of high boiling fractions ulectai by the Subcommittee on Carcinogenicity. The results of this itudy completed la 1 943 showed tha t h i g h b o i l i n g g as o i l s from c a t a - Ijtlo c r a c x l n g p r o d u c e d s x i n e a n e s r s on r e p e a t e d a p p l i e a t l o n to m l o e * Ibis finding led to the f o r m u l a t i o n of a comprehensive p r o g r a m of F -2- |ftr o h at K e t t e r i n g L a b o r a t o r y . T h i e p r o g r a m n e c e s s i t a t e d a c a p i t a l .{ to K e t t e r i n g L a b o r a t o r y of $ 4 0 , 0 0 0 f o r the c o n a t r u o t i o n of 1 quarters. (See attached list of expenditures.) The expanded .arch p r o g r a m got u n d e r w a y late in 1549. r1 jjgCTlTES - The r e a e a r e h p r o g r a m inoludea the f o l l o w i n g p r i m a r y ^jactiveei 1. T h e d e t e r m i n a t i o n o f w h i c h r e f i n e r y a t r e a m a a n d p r o d u c t a are carclnogenlo and to identify if poaaible the oausative agents in auoh atreama and produota. 2. D e v e l o p m e n t of r e l i a b l e a n a l y t i c a l t e c h n i q u e s f o r q u i c k a n d inexpensive determination of the caroinoganle potency of any stream or product. 3. I n v e s t i g a t i o n of p r o t e c t i v e m e a s u r e s w h i c h m i g h t b e app l i c a b l e to man. 4. S p l d e m i o l o g l o a l s t u d i e s t o d e t e r m i n e the i n c i d e n c e of o a n e e r among employees of the petroleum Industry as compared to the general population HOORE5S TOWARDS ACC0irPLI33r*3 T3S O B J E C T I V E S 1. T l e n t l f l c a t l o n of c a r c i n o g e n i c s t r e a m s o r p r o d u c t s a n d amative agents. To date 110 different petroleum fractions from fipreaontative p r o c e s s e s hav e b e e n tested on mice. Fractions of f o u r Afferent crudes are also b e i n g studied. Products of catalytic cracking *4 t h e r m a l c r a c k i n g of c a t a l y t i c gas o i l s h a v e b e e n s a m p l e d f a i r l y ^ l a t e l y , vacuum distillates including lube stocks are also under ttudy. A s u f f i c i e n t v a r i e t y of s a m p l e s is on h a n d to c o n s u m m a t e t h i s toas of the p r o g r a m . It has b e e n demonstrated that some carcinogens exist in the API 05320 - 3- ^ crude o i ls *nd that certain re fin e r y processing of o il fefftta> and/or ayntheaisoa oaroinogenio M atariala. High b o ilin g * 9lli {TOU o a t A l rtio o rack i n g h a r e oontinuad to s how re la tItaly A ^ eareino g e n l o p o t e n c y to mice. T h e r m a l o r a o k i n g of h i g h p o t e n o y '^ ^ o a l l y cracked r e a i d u a d o e s not reduoe the potenoy. Further* * high boiling gaa olla p r oduced in soTere thermal oraoking of fit run reaidua hare demonstrated high potenoy. untreated lube tillages show lo w ii* Polyoyollo to moderate carcinogen laity to mice. aromatioa vhieh fall into the general clasaea ^baoso(o) phenanthrone, benzpyrene and bensanthraoene hate been f i*d chemically in oaroinogenio olla. Certain oompounda in those sisea hate b e e n k n o w n f o r y e a r s to b e o a r o i n o g e n i o to mice. The itlo> clasaea of o(pound a or of inditi dual oarolnogona vary U oils de p e n d i n g u p o n t h e i r souroe a n d subsequent processing. Cam* ^listing the picture la the p r e s e n c e of m a t e r i a l s w h i o h in thornssites m not carcinogenio, bu t v h l o h h a t e the a b i l i t y to enha n c e the p o t e n c y if carcinogens in t heae oils. 2. Analy t i c a l T o o l - M a n y of the p u r e p o l y c y c l i c compounds wit h bon carcinogenic actirity hate an identifiable absorption spectrum li esrtain parta of the ultra*tiolet and risible range. Thla knowledge ha been used as the b a s i s f o r d o r s i o p i n g an analytical tool. Sapirlo relations of biological data w ith absorption spectra hate not thus to been e n t i r e l y aatifactory in p a r t du e to the n o n * q u a n t i t a t l r e tours of the b i o l o g i c a l testa and in p a r t due to c o mpounda w h o a e tomical o r p h y s i c a l p r o p e r t i e s influence carcinogenicity* b u t do not API 05321 toibit a c h a racteristic a b s o r p t i o n spectrum. The first of these factors has necessitated a program **fostment to study the b a s l o f u n d a m e n t a l s w h i o h lead to a quantitative - 4- j^gioal test. lfce oond f a c t o r ha s lad to a study of those chemical r physical propartias which lnfluanoa tha carcinogenicity of an oil _ Afl solTonts. v i s c o s i t y and e n h a n c i n g compounds. ^ * Obviously tha loata natura of tha problem of de v e l o p i n g an accurate analytical l plus tha ldantlflcatlon of tha causative agants in sufficiently .d classes to p a m i t e r aluation of oaro l n o g a n l e r e f i n e r y streams ^ require more time and effort than originally anticipated. Without ^ analytical tool, any laboratory proof of carcinogenicity rests upon jgjnal tasting w h i c h is e x p e n s i v e an d time-con tuning (three to twelve gfith required f o r e a c h test on mice). 3 , Preventive Measures - Animal experimentation and practical ^psrisnee in industry where occupational cancer hasards have existed Dtloate that this hasard can be controlled b y minimising expesure and ly adequate m e d i c a l s u p e r v i s i o n w h i c h w i l l include p e r i o d i c p h y sica l ixtalnations. Minimising exposure entails: a. Identifying the souroes of exposure. b. Informing the p e r s o n s w h o n a y b e exposed, of the h a s a r d Involved and of preventive measures. c. P r o v i d i n g of p r o t e c t i v e e q u i p m e n t o r f a c i l i t i e s ^ i e r e exposure is otherwise unavoidable. d. Oood p e r s o n a l cleanliness. Skin cancer if detected early is curable. An adequate mdloal program will insure early detection. 4. E p i d e m i o l o g i c a l Sur v e y - It is n o t p o s sible to t r a n s f e r d i r e c t l y API 0 5 3 2 2 the data f r o m the m o u s e testing e x p e r i m e n t s into f i g u r e s r e p r e s e n t i n g illative c a r c i n o g e n i c i t y of the vari o u s f r a c t i o n s f o r man. F r o m a Untific standpoint it would be desirable to test carcinogenic p o t e n c y 0(1 aeveral h i g h e r species of a n i m a l s i n c l u d i n g man. However, suc h 5ftiog l a n o t f e a s i b l e a t th e p r e s e n t tim e . i n t e r p r e t a t i o n o f tb s ^ p lfican ce of the experim ental d ata, th e re fo re, auat a a a lt prooure^ 9f d a ta on human oaaos from e p id e m io lo g ic a l s u rv e y s . As sp id sm io i6a i s u rre y i l l d e rs lo p th e f a o ta c c n e e m ln g th a I s o ld a s oa o f ^ r among o etro le u m w orkara a n d . I f o o r r e la te d w ith tb a o c c u p a tio n a l j)$tory, should d isc lo se w hether any p a r tic u la r oooupation in tha ^ troloua Industry is asso cia ted w ith an occupational oaneer haaard* addition, i t i l l d a ta c t any^/lncreaae In oaneara hioh aay be tha ^ault of f a i l u r e o f p r o t a e t i r a m easures. W ithout auch in f or o a : ion a pfoble of - a j o r m agnitude oould d e re lo p u n d ata o ta d and p r o te c tio n o f 0a petroleum in d u stry from u n au b stan tlatad claim s fo r oonpanaatian far a lle g e d o c c u p a tio n a l oanoer would be a lm o st im p o s s ib le . T his phase if tba program must be continued f o r a number o f p ears in o rd e r to be af value. T h is stu d y i s nov underway and th a a n n u a l o o s t i s low . jiolCLTSICW - O ccu p atio n al ca n o era com prise a v a ry emol p e rc e n te r* o f tbs t o t a l number of c a n o e ra . However, e x p e rie n e s in the B r i t i s h o o e l Ur in d u s try whorw o v er 1,4 0 0 o a se s o f a k in o an o er a r a d iag n o sed in i 20-y e a r period, and ex p o rle n o e from c o n ta o t w ith B r i t i s h s h a le o i l Sure over 1,500 oaaes of ak in oanoer v ara diagnosed in a s im ila r period, in d ic a te t h a t a o an o e r h a s a rd may asauma a s e r io u s m agnitud la in d u s try b e fo re o o n tr o l m easures e r a i n s t i t u t e d . B r i t i s h a t a t 1 s t io s uw p ro b ab ly a o re s o - u r a te th a n th o se in th a H alted S ta te s because r e porting of oases to the Government i s re q u ire d and am forssd. le d io a l lite ra tu re and unpublished re p o rta b o th in t h i s co u n try and abroad laoriminate c e rta in petroleum products whioh, having boon dem onstrated * anim als to havs a low d eg ree of o a ro ln o g e n lo ity , have eaused human tin ca n ea ra a f t e r expoaurea o f many year s d u r a tio n . The im portance of suoh o b se rv a tio n s to th e p etroleum in d u stry * ?b aslsas tba n eo e aa ity of a co n tin u in g program to dewelop th a f a c t s API 05323 -c- #il e tj promote any preca-tlonary measures that may be Indicated, ^is connection certain petroleum companies IP already instituted precautionary measures !< >tionB. Tn Crt Britain it is now mandatory in the united States within their own or^anithat white lubricating t* ^ad in cr.e phase ~f textile manufacturing. Il It is planaod that the research project (C-1) at sectoring fiborctory will proceed along lines of the objective* set forth above. 5^oh research activities have now reu.hed the peak and it is expected there will be a gradual decline in a year or two from njw unless jfcraeen situations arise in the interim. This caamittae will oe pleased to render any further progress ports which you may desire. Submitted on behalf of the committee by J \e. C h a i r m a n limbers of Faaearah Project (MC-1) Advisory Cornaittee. 1. 5. 'iewquist, M.D., X. S . id a o u i l. C. B eard , J r . lltffer ravie, M.D. R. 3. -Cckirit, V.D. T. . r'rank, .0. il. nine, k.C. R. M. London S. 7 , Linder X.D. X. 0 . v a c k e n x i e a. c. i t h o ff R. M. S h e p a r d e o n Chairman The Texas Coepany Standard Oil Co. (Ind.) Socony-Vacuum Oil Co. Phillips Pstroleum Co. Standard Oil Development Co. Pan Amarloan Refining Co. Shell Development Co. Oulf Oil Corporation Atlantic Refining Co. The Texas Company California Research corp. Standard Oil Development Co. (X.J.) (V.J.) API 05324 PAYXSSTS BY API to ^ I I V S R S I T Y 'jp CITTCITSATI l Rgr-ARCH rROJgCT (MC-11 GW CARClffOOSSICITT f.l- * 6 1-1-43 1-1-49 7-1-49 1*1--60 7-1-60 1-1-61 7-1-81 1-1-52 f 6,000*00 0 0 0 0 68.000. 00 (lncludoa $40,000 g ra n t fo r animal quartra) 0 49,418.00 39,968.89 50.000. 00 9,068.18 50.000. 00 31,698.48 $ 801,188.98 to Jua* 30, 1988 Budget J u ly 1, 1988, to JUno 8 0 , 1958 $ 1 0 4 ,7 6 0 .0 0 \ API 05325