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3M General Offices 3S6Mi5.UPCaeu3m3l.eM1i1N1055144-1000 _ 3 T 7 September 24, 2003 IJ By Hand Delivery Document Processing Center (7407) Office of Poilution, Prevention and Toxics U.S. Environmental Protection Agency 1200 Pennsylvania Avenue, N. W. Washington, DC 20460 Attention: Section 8(e) Coordinator Re: TSCA Section 8(e) Submissions Dear Sir/Madam: 3M Company ("3M") requests that EPA place the attached studies in the TSCA Section 8(e) docket. We have included a master index for these studies identifying the study title, test substance and CAS number. A Confidential Business Information (CBI) version of this index and the studies also is being submitted today pursuant to EPA procedures. 3M has not provided CBI substantiation with this submission, but would be willing to do so at the Agency's request. 3M has concluded that data in these studies may not be, strictly speaking, 'corroborative" of previously reported or published information as defined in EPA's reporting guidance or otherwise potentially may warrant 8(e) submission based on EPA's reporting guidance. 3M appreciates EPA's attention to this matter. Please contact the undersigned if you have any questions or require further information regarding this submission. . ' Very truly yours, A AT C. Dr. Katherine E. Reeo, t^n.u Staff Vice President Environmental Technology and Safety Services (651) 778-4331 kereed@mmm.com 37 ENVIRONMENTAL PROTECTION AGENCY TSCA CO--NF-IDEN1W2T0IA0ASLPHEBINNUNGSSTIYNOELNSV,SADNICNIAF20O4AR6VM0EATION CENTER Date & Time Stamp: Courier Receipt company Name: Received By: No. of Documents: Date: Q <3 ^ r O 5 i- 'S n co S'g * jo O Vj '-S3 September 26, 2005 Revision to 121 Studies provided in Master index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 jj^_ (Confidential Business Information Redacted) . . C t*.I*. Updated from July 15.2005 spreadsheet mm *i s f*6, i* 3 B 20% T R IP H E N Y LS U LF O N IU M ` ' 1 5 6 7 1 Primary Eye Irritation Study* Rabbits C H L O R ID H /B IS P H E N O L A F in trie th y le n e o ly c o l P-95-290 - N o C A S n u m b e r . co m m e rcia l 20% so lid s (E thom ert S /1 2 1 .0 M w ith 'd ie ttiy l s u lfa t 0.94M ); 80% w a te r [E th om e en S /1 2 = R - N (E t)+ (C 2 H 4 0 H )2 .w fie re R = C 1 8 w ith 1 -2 d o u b le 1 5 6 7 2 Guinea Pig Contact Derma! Irrftation/Sensiiization b o n d s ] .' 20% (61791-24-0 w ith 6 4 -6 7 -5 ): 80% 7732-18-5 1 5 6 7 3 Primary Eye Irritation Study - Rabbits B u ta n o ic a c id , h e p ta flu o ro -, c a lc iu m s a lt ' 2366-98-5 Acute Orel Toxicity Screen withT*2712CoC in 1 5 6 7 4 AJbinoRabbits p e rfiu o ro h e x a n o ic acid 3 0 7 -2 4 -4 Primary.SWn Irritation Test with T-2725EC(Repeat 1 5 6 7 5 Application) hi Albino Rabbits' (l Acute Ocular irritation Test vwthT-2725c 'h Albino ....................... n - . . 1 5 6 7 6 Rabbits....... ;............................ , ' [) ' . [1 . ' V- . 2 -P fo p e n o ic a c id , 2-m ethI-, o c ta d e c y l e ste r, p o ly m e r co m m e rcia l R&D R&D R&D R&D. . . . . w ith. _ . . . . . ' . " . ' ' ;1-.di.chIoroethene. 2 - [[(h e p ta d e c a fiu o ro o c ty t)s u lfo n y l]rn e th y la m m a ]e th y l; Sensitization Studywith T-2741A.C In Albino Guinea .2 r p r 6 p e n o a td ,' N -(h y d r o x y m e th y l)- 2 - p r o p e n a m id e , 2 - 1 5 6 7 7 Pigs.. [m e th y l[(n o n a flu o ro b u tyl)su lfo n yl|3 m in o le th yl 2-p ro p - 7 0 7 7 6 -3 6 -2 . ' . co m m e rc ia l Ora! Rangefinder Study,of T-31408S in Pregnant 1 5 6 7 8 Rats- . .. 1 -(3 '-(p fflu o ro o c ta n e s u lfo n te ) a n ilin o a m id e ]-2 p p ta s s u m 3 ,4 ,5 ,6 -te tra c h tp ro p h 0 j t i . . .- 57589 85-2 co m m e rc ia l 8 0 % 1-[3 '-(p e rJlu o r6 d cta n e su lfo n a te ) a n ilin 6 m id ]-2 - po ta ssiu m 3,4,5 ,& 4etrachtorephthalate ; 5 % C 7 . Oral Rangefinder Studyof T-3139BS in Pregnant ho,In u io g , .5 % C 5 h o m o lo g ; 5 % C 4 - h o m o lo g ; 5 % C 6 . 8 0 % 5 7 5 8 9 - 8 5 ^ 2 ; S % -6 8 5 4 1 - 0 1 - 5 ; 5 % 6 8 5 4 1 - 0 2 -6 ; 5 % 1 5 6 7 9 Rats ,. h o m o lo g . ' 68568-54-7; 5% 688 15-72-5 '` co m m e rc ia l Acute Occuiar Irritation Test withT-2997CoC in prfitio n d e th ylcyclo h e xytsu lfo n ic a d d d ie th a n o l a m in e 1 5 6 8 0 Albino Rabbits * . . s a lt Sensitization Studywith T-33BS inAlbino Guinea - 1 5 6 8 1 pigs " . .' ' n in Vitro Microbiological MutagenicityAssays of SM - ' ... 1 5 6 8 2 Company'sCompound T-3411 . .H . N o C A S # fo r Salt b u t i l is th e s a lto f[1 3 3 2 0 1 -0 7 -7 ][1 1 1 - 4 2 -2 ] ' co m m e rcia l ri . R&D' U' ______________________ ' R&D a i ? ^ S tg f)tiS i? 3 iS i none' ' . . .. . none none none R&D R&D . . ' none . rione ' . hone none . ' R&D - . R&D Acute Oral Toxicity Screenwith T-3448 in Albino 1 5 6 8 3 Rats -. ' 6 8 % p o ly (o x y -1 ,2 - than ediyl), a lp h a -[2 - teth yl[(tie p ta n e d e ca tlu o ro o cty()su tto n ylja m in o le th yl(- o m o g y h y ro x y ^ ; .i2;% p o fe tb y le n e g iy c o l; 7 % w a te r; 4 ;8 6 % j^ (o )iy :4 ,2 - th a n e c iiy l),a !p h a -{2 - [e th y ii(p e rita d e ca flu o ro h e p tyi)su lfo n ylja m in o ]e th yl]- o m e g a -h y d fo x y r; 4 % re sid u a l o rg a n ic flu o ro c h e m ic a i; 3 % h e p ta d e c a tiu o ro -i-o d a n e s tiifo n ic a d d ;.0 .8 1 % pl(oxy-1,2-ihanediy!> , a lp h rF p - . [ethy1 [{u n d e ca flu o ro p e n tyl)su tfb n yl]a m in o ]e th yt]-o m e g a - 6 8 % 2 9 1 1 7 -0 8 -6 ; 1 2 % 2 5 3 2 2 -6 8 -3 ; 7 % 7 73 2 -1 8 -5 ; hydroxy-; 0 .3 % 1,4-dioxa ne; 0 .2 % n - . e th y lp e rflu o ro o ct n e su lfo n a m id o e th yl a ico h o l; 0.03% 4 .8 6 % 56372-23-7; 4 .0 5 % 682 98-79-3 ; 3.24% 68298 8 1-7; 3 % 176 3-2 3-1; 0 .8 1 % 6 8 2 9 8 -8 0 -6 ; 0.3% 123-91 lin e a r tv e th y l p e rflu o ro o c ta n e s u lto n a m ld e 1; 0.2% 1691 -99-2; 0.03% 4151 -50-2 com m e rcial io n e !nVitro Microbiological Mutagenicity Assays of 3M 6 5 % d ie th y ie n e .g ty c o i b u ty l e th e r ; 2 5 % flu o r o c h e m ic a i 1 5 6 8 4 Company's Compound T-3516 . u rethane; 10% w ater; 1% m eth yl e th yl ke to n Acute Derma! Toxicity Study with T-3451 in Albino 1 5 6 8 5 Rabbits ' C 8 F 1 7 S 0 2 N {C H 3 ).N a 65% 112-34-5; 25% 306 973-47-7; 10% 7732-18-5; 1% 78-93-3 com m e rda l 879 88-59-8 (t-O c ta n e s u ifo n a m id e , 1.1 !2 '.3 ,- 3 ;4 .4 ;5 .5 ,6 .6 .r .7 t8 r8 ,8 - h e p ta d e c a flu o n > N m e th y l-, sodium s a l t ) R&D io n e tio n e * Final 1 31 \. September 2 6,2 0 0 5 Revision to 121 Studies provided in Master index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 . (Confidential Business Information Redacted) Updatedfrom July 15.2005 spreadsheet Acute Oral Toxicity- Method, Summary, Pathology; Primary Dermal Irritation Method, Summary; Primary Eye Irritation - MotHod, Summary, Guinea 15686 Pig Maximization - Method. Summary .n Acute Oral Toxicity-Method, Summary, Pathology: Primary Dermal Irritation - Method, Summary; 15687 Primary Eye Irritation - Method, Summary; n Dermal Sensitization Study.inGuinea Pige, 15688 Maximization test - Method, Summary n ' n n n R&D R&D R&D ,' fiuorochemical diluted in 1,1.1-trichloroethne; fluordchemical = 37% ' C28H28F17N308S.C27H28F15N308S.C26H28F13N3 Q8S.C25H28F11N3O8S:ei4H10Fi7NO4S;G13H10F1 5NO;26% methyl isobutyl keton; 26% FREON 113; 5% 4 HourAcute Aerosol inhalation Toxicity Study,with- Stoddard solvent; 3% l-aziridinecartxwamide . -15689 T-3825 in Rats . . derivative; 3% methylchloroform .15690 Primary Eye Imtadon/CorrostcnStudyjn Rabbits; 2-t]epianuorobutyramcio--'(-criloro-.5;nilropheriol ` ' 37% 68298-78-2; 26% 108-1.0-1; 26% 76-13-1; 5% . 852-41-3; 3% 68583-98-2; 3% 71-55-6 . commercial .. 13^326896-5 ' . ' ' . . . commercial - . ' fiuorochemical tiiluted.in 1,1,1-trichloroethane; fiuorochemical = 37% .: . C28H28F17N308S;C27U28F15N308S.C26H28F13N3 0'6S.C25H28F11N30BS.C14!)10F.17N04S:C13H.10F1 5NO;26% methyl sd&uiyTkCtohe; 25% FRON 113; 5% 4-HourAcuteAerosol InhalationToxicity Studywith- Stoddard,solvent; 3% 1-azirtdinecartx)xamide . 16691 T-3825 in Rats, ' . derivative; 3% methylchloroform ' 15692 T-;38};-.Acute InhalabOfiToxicity Test- . 2-mfhyl-2rptopeooate v . -, 91% 1,1.1-trichloroethane; [};[] methylal; [J 1,2- 37% 6829878-2; 26% 108-10-1; 26% 76-13-1; 5% 8052-41-3; 3% 68583-98-2; 3% 7.1-55-6 38905-21^4 . .. commercial. not commercial in US 15693 T-3821: Acute InhalationToxicityTest 15694 T-3845Acute Inhalation ToxicityTest butylen oxid); f] . heptafluorobutyryf chloride . 93% 1,1,1-trichlo.roetiiane; 2% melhylal; 2% 1.2- 91%.71-55-6;[J; f] 109-87-5; f 106-88-7; i l 375-16-6 . not.commercial in US . commercial butylene oxide,\t% rrithyl'ethyl'ktrie; 1% methyl sobutyl ketone; 1% . ' C28H28F17N308S.C27H28F15N308S.C26H28F13N3 -valuation of theAcute'InhalationToxicity of T-3920 08S.C25H28F11N308S.C14H1F17N04S.C13H10F1 93% 71t55-6; 2% 109-87-5; 2% 1Q6-86-7; 1% 78-93-3; 15695 ntheRt ' - UNO - ... . ' ' 1% 108-10-1 ; 1% 68298-78-2 . . commercial Primary Eye Irritation Study In Rabbits - Method, . 15096, Summary . .' '. AcuteOra!ToxicityStudy teRats (OECD 15697 Guidelines) . . ' Pecanoic acid.nonadeaflubrT, ammonium salt ' 95% ammonium periluorodecanoate; 5% ammonium perfiuorooctahoate ` 3108-42-7 5% 3825-20-1 . . R&D - , R&D - R&D R&D R&D . . none . . norie ' . none .. none * notcommercial in US. none none ione. ione Final 2 September 2 6,2 0 0 5 Revision to 121 Studies provided in Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 . (Confidential Business information Redacted) . Updated from July 15,2005 spreadsheet l 95% 1,1,1 drich loroetharie; 5% fluorocbcmicat Acute inhalation Toxicity Study with T-4129 in the (fluorochemical = 8 5 8 7 % methyichloroform; 10% 15898 Rat ' . ' . . fluorochemical polymer) . . .. 3 5 % 71*55-6; 5% mixture Of 3 8 -8 7 % 7 1 -5 5 -6 ,1 0 % 1 t6 8 5 5 5 -9 2 -0 , 0.1-2% 1 09 -87 -5, 0 .1 -2 % 106-88-7; C A S i esSSS^S^p is 2-Propenoic acid, 2-methyl-, 2- [(( h e p ta d e c a llu o ro o c ty l)s u lfo n y l]m e th y la m in o ]e th y l ester, polymer with 2- . [mefhyl[(nonafluorobuty1)sulfonyl]amino]ethyl2-methyl- 2-prOpenoate, 2 - ., . [m e th y l[(p en tad eca flu q ro h ep tyl)su lfo n yl]am in o ]eth yt2 - methyi-2- propenoafo, 2- " Emethyl((iridecanUorohexyi)sulfonyl]amino]ethyl2- m ethyl-2-propenoate,:?- [m e th y i((u n d eca flu o ro p en tyl)su ifo n yl]am m o ]eth yl2 - methyi-2-propenoate and octadecyl 2-methy|-2- properioate . . . . . ;' . commercial ` none 94% 1,1,1-trichlbroethane; 6% fluorochemical ((iudipichernical.= 3 7 % C 28H 28R17N 30aS,G 27H 28F15N308S.G 26H 28F13N3 O 8S,G 25H 28filN 3b8S;C 14H 1bIf17N O 4:S.C i3H 10Fi- 5N O ; 2S% m ethyl isobutyl ketone; 25% F R E O N 113; 94.% 71-5 5 :6 ; 6 % o f(3 7 % 6 8 2 9 8 -7 8 -2 ;.2 6 % 108-10-1; Attila Inhalation ToxicityStudy with T-4130 in the'. 5 % Stoddard solvent; 3 % 1-azfridinecarboxam ide . 156 99 Rat . - derivative; 3% methyichloroform) .. . 2 6 % 7 6 -13-1; 5% S052-41-3; 3 % 6 85 83-98-2 ; 3 % 71 55-6) . .. . . . . commercial Acute Oral toxicity Study in Rate; Acute Dermal Inflation&udy IrRabbits* Acute-Eye irritation- P M N # P-96-1262 - CAS 306974^45-8 - PMN nam eluily ' 1 5 7 0 0 Study in Rabbits .. . - Polyoxyethylene Diam ine Perfluorooctyl Sulfonate disclosed orrS N U R . ' . commercial Derma! Sensitization Study in Guinea Pigs - tributylmethoxypropyl phospfionium chloride/Bisphenoi 15701 Maximization Test . ` - AFcoriiplex . . . . . . . . PM N# P-95-290-N o CAS number ' " commercial' MutagenicityTest on T- 4413 {' ] n'ie I5178YTK-U 0 : 5 4 .9 % water; ( ] polyethylene glycol " Mouse Lymphoma ForwardMutationAssay with sprbitahnipnooleate; [ ] ; [ ] 2,6-dim ethyM ,3-dioxan-4-ol 15 7 0 2 Diiipfcate CuHtffes ' ` acetate' . '' . . . f t n : 54.9% 7732-18-5;.fl 9005-65-6; f); [1 828-00-2 commercial Acute Inhalation ToxicityStudy with T-4354 in the ' 15 7 0 3 RaL .' ' . 78.3% water; f ] . ; , / 78 .3 % 7732-18-5; [1 ' ' , commercial tributylmethoxypropyl phosphonium chloride/bisphenol 157 24 Primary Derma! Icritation/CorrosionStudy in Rabbits A F com plex , P-90'229 - No CAS number commercial 9 5 -9 9 % 1 .1 ,1-triChloroethane; 0-3% dim ethoxym ethane; ' . 0 -2 % t-butyi aicohoi; 0 -1 % 1,-2-butyiene oxide; 0.5-1.5% ' Acuta InhalationToxaty'Stdym tfis Rat withT-' ' flBowetiemicai solidsm Sdure; 0 4 .5 % metrtyi Pifiyi 95-99% 71-55-6; 0-3% 109-87-5; 0-2% 75-65-0; 0-1% ' 15725 4397' . ' . . ............ . ketone-..... Primary Eye rritation/Corrosion Study ofT-5261 m ' ; ' ' ; . 106^88-7; 0.5-1.5% 68298-78-2; 0-1.5% 108-10-1 ' commercial .15726 Rabbits . lithium tetrafluoroethane-1,2-disulfonlm ide Unknown R&D 96.173% Isopar G ;1 .5 9 6 % heptane; 0.7% sulfonamides, C 4-8-alkane, perfluoro, N-(hydroxyeihyl)- 9 6 .1 7 3 % 647 42-48-9; 1.596% 142-82-5; 0.7% . 9 1 0 8 1 . 1-methyl, reaction products with epichlorohydrin; 99-1 = C 4-8-alkane, perfluoro, N-(hydroxyethyl)-N- Acute Inhalation Toxicity Evaluation on T-5231 in adipates (esters); m icelianeous com ponents (each less methyl, reaction products with epichlorohydrin, adipates 15 7 2 7 Rats . thani% ) 1-Hour, Acute Inhalation Toxicity Study with T-5305 15 7 2 8 n Rats ' I . _ 1-Hour, Acute Inhalation Toxicity Study (Limit Test) 15 7 2 9 .withT-5343.1 in Rats - . . ) . esters) :i J . .` -- commercial . . not com m ercial in U S . not com m ercial in U S -Hour, Acute InhalationToxicity Study With T-5306 1 5 7 3 Q i n Rate 1 - ' lot commercial in U S 37% heptane; 2 5 % fluorochemical hydrocarbon t -Hour, Acute Inhalation Toxicity Study (Limit Test) solyacrylate copolymer, 18% ethyt acetate: . 15731 vlth T-6357.1 rniscellaneous components (each less than 1% ) >7% 142-82-5; 2 5 % 685 55-92-0 ; 18% 141-78-6 ommercial none none none * Trade Secret mixture Trade Secret, mixture , none . honenone Tone rot com m ercial in J:S.. ilo t com m ercial in lJ . S . rtot com m ercial in lJ.S. r one September 2 6 ,2 0 0 5 Revision to 121 Studies provided in Master index to Studies Submitted Under TSCA 8{e) by 3M Company on September 2 4 ,2 0 0 4 . . (Confidential Business Information Redacted) Updated from July .15.2005 spreadsheet ' i. 157 32 Acute Dermal-Toxicity Study of T-4201 in Rabbits Lithium Bis(Trifluoromethanesulfonyl)imide SubAcute 28-Day Oral Toxicity with T-2816 by Daily Sulfonam ides. C 4 -8-alkane , perfiuoro, N -[3Gavage in the Rat Followed by a 14 Day Recovery (dimethylaminoJpropyQ, reaction products with acrylic 157 33 Period ' acid . . 90076-65-6 P-80-183-N o CAS# Subacute 28;Day Oral Toxicity with T-2816 by Daify Sulfonam ides, C 4 -8-alkane , perfiuoro, N -[3Gavage in the Rat Followed by a 14-Day. Recovery (dimethylamino)propyO, reaction products with acrylic, 157 34 Period ` ' - acid . P-80-183-N o CAS# 9 4 .8 2 8 1.1.1-trichtoroethane; 1.59% dimethoxymethane 1.224% t-butanol; 0.489% fiuorochemical hydrocarbon Acute Inhalation Toxicity Evaluation on T-5187 in polyacrylate copolymer; m iscellaneous com ponents 15 7 3 5 Rats .- (each less than 1% ) . 9 4 .8 2 8 7 1 -5 5 -6 ; 1 .5 9 % 109-87-5; 1:224 % 7 5 -6 5 -0 ; 0:469 68555-92-0 . 157 36 T-4240 4-Week Oral Toxicity Study in Rats . Sulfonam ides. C 4 -8 alkane, perfiuoro, N-m ethyl-N -[{3- octadecyi-2-oxo-5-oxazo!ldmyl)methylj . P-90-111; CAS# 138704-55-9 ' ' ' co m m ercial com m ercial co m m ercial . com m ercial com m ercial ... none none norie ' nne . Trade Secret - .. T r a d e N m e . Dermal Sensitization Study of T-5473 in Guinea ' , 15 7 3 7 Pigs- Maximization Test - 6 0 % w a te r,! ]; 6 % ethylene glycol; [ ] ; 1 .5% unknown; [.] 6 0 % 7 7 3 2 -1 8 -5 ; (.]; 6 % 107-21-1; [ ]; I ] 903 6-1 9-5; 1% ' polyoxyethylene monodctylphenylelher;J % acetone;.!;] 6 7 -6 4 ,1 ; I ] - , ' 4 8 . % Isppar H; 48.5% propylene glycol roonomethyl co m m ercial 4-Hour, Acute InhalationToxicity.StudyWith T-5698 e th e r aceiate; 3 % M -m ethyt perfiuoro octane ' 15 7 3 8 inRate . . .. ' sulfonamide pripol 1040 ester 4S .5% 6 4 7 4 2 -4 8 -9 ,4S;S% 108-05-6; 3% PMM P-92- , 1 .4 6 2 -1 4 6 6 -N o C A S numbers com m ercial' ; Acute inhalation Toxicity Evaluation On T-570U in. . 15 7 3 9 Rats-. ... `. 96.17.5% Isopar G; .1.604% h e p ta n e ;!] 96.175% 64742-48-9:1.504% 142-82-5; f f - commercial T-5486 Assessment of Cardiac Sensnization .1 5 7 4 0 Poteiitiai-in'Dog-. ' 1 . - ' ' ' ' oetafluoropropane . . -/-is-? ' . commercial ' 1574:1 ARcu&t:e Inhalation ' .Y ' Toxicity . -;7 Evaluation :: ' onT-5655 . ' in T-42014 Week Oral Toxicity Study inRats with2- 94.59% .naphthol spirits; 1 .8 9 % hep tan e; 1.1% 1- . roetboxy-2-propyl acetate; f ] . . ", 94.59% 64742-48-9; 1.89% 142-82-5; 1.1% 108-65-6; ( 1 ''' ' com m ercial 1 5 7 4 2 Wek Recovery Period Lithium Bi5{Trifluorsmethanesulfonyl)imide 90076-65-6 \- ' ' .' com m ercial 1 5 7 4 3 T-5658: Eye irritation to'the Rabbit ' ` triphenyl5Ulf6nium:chloride:C8 sulfonam ide com plex P M N # P -9 7 -3 3 5 - N o C A S num ber commercial . ActeIhhaitiilTcpeciVEvaiuation on T-5715 in 9 9 :5 9 % naphiholspirits; f ]; m iscellaneous com ponents - 157 4 4 Rati ' ' ` (each less than i% ) ' . " . ' 99:59% 64741-65-7; t l '' com m ercial' ' Acute Inhalation Toxicity Evaluation on T-57-16.in 1.5745 Rats- . . . ` '. ; " 99:9 2 % naphthotspirits; f l ' 99.92% 'f>4741-65-7; ['] ' ,' com m ercial : 1 5 7 4 6 AcutelnhatationToxicity.Study ofT-5724 fcvRats 9 6 % Is o p a rG ; i.6 % h e p ta n e ; [ ] ' . 96% 64742-48-9; 1.6% 142-82-5; f ] ' ' com m ercial . Acute inhalation Toxicity Study ofT-5725 {Resin . `... 15 7 4 7 Solution) m Rats'- ` 9 6 % naphthid!spirits; 1.6% heptane; [ ] ' 96% .64741^5-7; 1 6 % 142-82-5; H commercial Acute InhalationToxicityStudy-(Umft Test) of T- " 1 5 7 4 8 5927 ih Rats 93.1% w a t e r - ! ] . Acute inhalation Toxicity Study ofT-5928 in RaU [ ]; 7 % isobutahe; 86:1% w ater, 0 .0 6 % ethanotamine: . 157 49 <LC50). " . 0.00.1 % acejic .a c td ' ' - ' ' 93:1% 7732-18-5 ; f i . 7 %[ ]; 7 5 -2 8 -5 ; 8 6 .1 % 7 7 3 2 -1 8 -5 ; 0.0 6 % 141 -43 -5; 0.001% 64-19-7; { ] . ... '. com m ercial co m m ercial Acute Inhalation Toxdt Evaluation on T-5829 in 157 50 Rts . . . . . 93.1% w ater; 2.8 % 1-(2-butoxypropoxy)-2-proponol; Single-Dose intravenous Pharmacokinetic Study of 5.(N -m elhylTperf1u6rooctanesulfonamido)rnethy!-5- 157 73 T-59S3 in.Rabbits . . octadecyt-2-oxa7p!i-ilihone 43,7% w ater;.30% ammonium [ ] 9.3.1%.7732r i 8 - 5 ; 2.8% 2 9 9 1 1 -2 8 -2 ;!) . PM N# P-90-111 * CA S 306974*19-6 - PM N nam e disclosed on S N U R co m m ercial . commercial bis[ethy!{perfluorooctane)sulfonayi]phosphate; 20% isopropylalcohol; 8% Nrethyi heptadecafluoro-N[2- Single-Oose Intravenous Pharmacokinetic Study of (phosphonodxyJethyO octanesulfonam ide diam m oinum 4 3 .7 % 7 7 3 2 -1 8 -5 ; 3 0 % 303 81-98-7 ; 20% 67-6 3 -0 ; 6% 15774 T-6030 h Rabbits ' salt' 0,3% toluene - 67963-69-1; 0.3% 108-88-3 . : commercial Trade Secret fniktur , none ; ' Tracie Secret . : mixture ; . none Trade Secret . mixture . ' . ". ' ' none. ' " . , none TradeScret' . . mixture . TradeSecret m ixture. ' Trade. Secret - ' mixture Trad Secret m ixtiire ' ' . ' T ra d e .S e c re i mixture .. TradeSecret m ix tu re . Vrade-'Secret - rriixtur . ' - T ra d e S c re t- rrade Name F ra d e S e c re t- . FradeN am e . F in a l . 4. September 2 6 ,2 0 0 5 Revision to 121 Studies provided in Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 2 4 ,2 0 0 4 (Cnfidntial Business Information Redacted) , Updated from July 15,2005 spreadsheet . -- 87-93% fiuorinaied aikyi aikoxylales; 4 -10% linear N - i ethyl perfluorooctanesulfonamide; 2 -4 % poly(oxy-1,2- ethanediyl),.alpha.-(2- : [ethy1 [(p e n ta d e c a flu o ro h e p ty l)s u lio n y l]a m ln o ]e th y l]- 87-93% 68958-61-2; 4-10% 4151-50-2; 2-4% 68958-60 .orrega.-rnnthoxy-; 0-4% residua) organic 1; 0-2% 31506-32-8; 0.1-1% 68957-62-0; Residual fiuorcfohe.rriicals; 0 -2 % c8 sulfonam ide; 0.1-1 % 1 - ' Organic Fluorochemicals m ay consist of one or m ore o heptanesulfonamide; N-eihyl: . 5-Daily Dose Dermal Absarptionfl'oxJcity Studyof T- 1,1,2,213,3,4,4.5,5.6,6,7,7,7-pentadecafiuon-: 157 75 6029 and T-6032 in Rabbits . miscellaneous components (each less than 1% ) 5 4 .9 7 % water; ( ]; 8% meihyl isobutyl ketone; 5.5% th e following C A S num bers: 2 7 9 5 -3 9 -3 , ;'4 4 -*8 -0 9 -7 i 1691-99-2. 87988-71-4. 31506-32-6, 4151-50-2, 8 /3 8 8 6 i - 2 , 213181-79-4.213181-78-3 and 754-91-6. co m m ercial Sihgte-Dose Intravenous PharmacokineticStudy of. ethylene glycol; m iscellaneous com ponents (each less 157 76 T-6061 in Rabbits ' . ' than i% ) .' . ' 54.97% 7 7 3 2 -1 8 -5 ; [ ]; 8% .108-10-1; 5.5% 107-21-1 co m m ercial Single-Dose Intravenous PharmacokineticStudy.bf 6 2 % w ater; 30% .fluorochem ical.acryla!e; 7 % 157 7 7 T-i60i35in Rabbit3. . polyethylene glycol;'1% ethyl acetate- " 6 2 % 7732-18-5; 30% 66586-14-1 ;.7% 25322-68-3; 1% .141-78-0 . .. . commercial-. Single Dose Intravenous Pharmacokinetic Studyof 6.0% w ater; [ ]; m iscellaiTeous.coiiiponents (each less 157 78 T-6053in Rabbits * /. ' than 1 % ) .- 6 0 % 7732-18:5; [1 . . . commercial Trade S ecret. Trade Name. . -. . .. , . .' Trade Secret mixture . Trade S e cret- . trade.N am e. .. Trade Secret1 . mixture 8 6 % wafer; 7% isobutane; (); 2.8% ' 1-(2-butoxypropoxy)- 157 79 Acute InhalationToxicity Study of T-6235 in Rats 2-propan'ol; 0 .7 5 % 1-m ethoxy-2-propanol; 0.189% unknown; 0.06% eihanolamine; 0.001% acetic acid . 9 .4 % polym ethaciylate;. 15;5,%.-so-dium - ... * 86%:7732-1515; 7% 75-281% 2.8% 29911-28-2; 0 7 5 % 107-98-2; 0.06% 141-43:5; 0:001% 64-19-7; [ ] com m ercial- Primary Dermd.Jmtatlon/Corroawi Study ofT-6402 dodecyiDertzfenesuIfonate^ 5 .4 % f ];'6 9 .6 9 1 % water: . 157 80 m Rabbib ' . ' ' ' 0 .009% -1,2-dibro'mo-2;4-dicyanobutane . 9.4 % poiymethacryiaie; 15.5% sodium Dermal SensitizationStudy of T-64p2in Guinea dodecylb'ehzCnesuIfonBte; 5 .4 % [ ];'69.'691% water; -15781 Pigs* Mai>ttmzab'onTest(C GutdeHnas) 0 .0 0 9 % 1;2-dibrorrio2,4-dicyanobutane Acute Eye tfritationrcondsion Studywith7-63l8 in 15 7 8 2 theRabbrt* . * n ' 9% .2-ethyhl-hexanpl,Titanium (4*).Salt; 15% '2- . 9:4% 25087-26-7; .15.5% 25155-30-0; 69.631% .7732- i 8-5; 0:009% 3 56 91-65-7 (1 . . R&D . 9.4% 25087-26-7; 15.5% 25155-30:0; 69.691 % 7732- 18-5;'0.009% 35691-65-7; f ] ' ' . RAD tr : ______ '_________:_______-- ____ - interm ediate; not com m ercial Primary Skin Irritation / GoniosionStutfy.wBh T-85S7 butoxyethyl acetate; 5 2 % naphttiol spirits; 2 4 . 157 83 inthe Rabbit`(4-Hour Semr-Ocdusive Appficaton) fluorochem ical Hydrocarbon polyacryiate copolymer 9 % fl: 1 5 % 112-07-2; 5 2 % 647 4 2 -4 8 -9 ; 2 4 % fl commercial Trade Secret m ix tu re . RAD RAD none ' ' Trade Secret . mixture ' 1 Assessment of Contact Hyperserutivrtytp T-6318 in- 1-Butanesuinfifc acid. 1,1.2,52,3,3;4,4.4-nonaituoroT( , ' 15784 theAibhoGumeii f^{MaxinMzat!bnTest).. SodiOm Salt . . . -' .. 1 0 2 0 6 1 -8 2 -5 . . ' . interm ediate (initiator) Single-Dose Intravenous PbarmacolgnefcStudy of- 157 85 T-6502in Rabbit's .' n ' PMN# P -97-228-N o CAS# RAD . Single-Dose intravenous Pharmacokinetic.Stydy.of. 157 86 T-6504 `Rabbits ' n. n. ' - ____________________ _ _____ ______ _____________ R A D Single Dose Intravenous PharmacokineticStudy of 15787 Tr6506 ih Rabbits ' . . f.i - '' n RAD . ' none . R & D ' ` R & D R&D. * A Study for Effect on Embryofoetal Development of 20430% .m ethyl no.natluorpis.ob.utyl ether; 20-80% methyl ' 157 88 the Rat (InhalationAdministration) . - narifluorobutylether ' ' . 20-80% 163702-08-7; -20-80% 163702-07-6 Triphenyl Sulfonium Chloride / Hexafluorobisphenol A Complex = 21:2% BF5 in various forms; 4 % Structure I; 1.1% Structure II; 1 0.1% Structure III; 5:8% unknown; 43.3% ethyl alcohol: 11.8% methyl alcohol; 4.3% 43.3% 64-17-5; 11.8% 67-56-1; 4.3% 67-63-0; P-95 15 7 8 9 Bacterial Reverse Mutation Test of T-6695 Isopropyl alcohol . ' 5-Daylhha!atjonToxiCity of Pertuorocydohexene . 15 7 9 0 (C5F10; T-6878jm Rats \ . - perfluorocyclohexene . 5-Dally Dose Dermal Absorption/ToxicUy Study ofT- 1 5 7 9 6502 and T^6503 `Rabbits' - * . `n Primary Eye Irritation/Corrosion Study of 7-6766 in 15792 Lithium Bis(perfiuoroethyisulforiyl)imide Primary Dermal Irritation/Corrosion Study of T-68.04 15793 in Rabbits Lithium Bis(perfluoroethylsulfonyl)imide 15794 5-Day Inhalation Toxicity Screen of HFE c-601 C -C 6 F 1 1 G C H 3 290 ' ' - 355-75-9 .. PM N# P -97-228-N o CAS# 132843-44-8 . 132843-44-8 4943-08-2 ` ' commercial . com m ercial RAD R&D com m ercial co m m ercial com m ercial . ' ' none ' ' none none R&D none none {none Mnal 4^ September 26, 2005 Revision to 121 Studies provided in Master index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 - (Confidential Business Information Redacted) . Updated from July 1 5.2005 spreadsheet (Primary Eye initaoon/Corrosion Study of T-6804 in ai 1579!5 Rabbit (OECD Guidelines) Lithium 8is(pen1uoroethyisulfonyi)imide i. 132843-44-8 --......... .................. co m m ercial none 1579E Guidelines) Dermal Sensitization Study of T-6908 In Guinea 15797 Pigs. MsziYniratipnTest (EC Guidelines) Eye Irritattori/CorrosionStudy of T-4127 In the 15798 Rabbit Single-Dose Intravenous Pharmacokinetic Study ol 15799 T43924;n Rabbis .. Lithium BisfpprfiuoroethylsuJfohyQimide 5 6 .5 % water; [ ]; [ ]; 1.5% sodium di(2-ethyihexyl) sulfosuccinate;'0.81% polyethylene glycol sorbitan nionooleate;'0.27% ethylene glycol; 0.13% ethyl alcohol; 0.10% dimethoxane '' Triphenylbcnzy! Phosphonium /C 8 Sulfonamide C o m p le x n- 132843-44-8 . commercial 58.5% 7732-18-5; []; 1.5% 577-11-7; 0.81% 9005-65 6; 0.27% 107-21-1; 0.13% 64-17-5; 0.10% 828-00-2 commercial P-88-141 - No CAS# n . .' co m m ercial R&D none Trad Secret . none . R&D ' . 15800 R^-Maxfrrtzaticv Test (EC'GtideJmes). Dermal Sensitization Study of T-7003 in Guinea n .. - - '. . '15801 Pigs - M^niiaiionlTostXEC Guidelines).. \ ... . h . : Report of Sera and Liver Data (or FC-807 ' N^ethyi heptadecafluoro-Ni2-(phtisphohooxy)ethyi] . 158 02 Monoester.-.Prefiminary ADME- Study in Rats, ... octn'esfn2mideyfa.rnrrioniuni sa lt................. ` n n ' - ' 67909 69-1 . ' ' FC-807 Drester-Pharmarota'netjc Slydy ja Rats .. a.nirnohiiim ................................. ........... : , . ' .15803 ( S t u d y N p ; T : 7 W 3 v t ; . bis[ethyt(perfiuofOOCtane)su!fohayi]phosplia!;e': `: : 30331-28-7 ` . ") 55%:-polyeihylene glycol distearate; 27.5% 'glycerol .rnonostearate;-15% hexane; 1 .e-dfisocyanateK ' homopolymer, N-(hydroxyethyl)-N-methyl perfluoro C 4 -8 5 5 % 9 0 0 5 -0 8 -7 ; 2 7 .5 % 315 6 6 -3 1 -1 ; 15% P -99-188 Smflle Dose Intravenous. Pharmacokinetic Study alk a n e sulfonam ide-and stearyl alchohol blocked; 2 .5% {C A S 3 0 6 9 7 8 -6 5 -4 ) n am e disclosedo n S N U R ; 2.5% . ' 158 04 wjtii,Tr7p&2 ip Rabbit*. . cationic fatty derivative. ' " 68039-12-3 , '" '. ' FCr807 Monoester - Pharmacokinetic Study in Rats N-ethyl hptadecafluoro-N[2-(phosphonooxy)thyI] . 15805 (StudyNo.T:S037^) * . . octanesulfonariiide diarnmoniurn.stt - . 67969-69-1 ' ' ' .' . R&D R&D . co m m ercial ' commercial co m m ercial c m m rciai ' R&D R&D none ' ' none - ` Tracie S e c re t- T f d e N a m e nne Concentration inSeam from the Dermal Absorption Studies.ofT-7106 and T-7107 In Hrac(NZW)SPF . 158 06 Rabbits. ' 9 8 .2 5 % polypropylene; [ ] . 98.25% 9003-07-0; r i : ; R&D . ' R&D - Qennat Sensrilzation Study of T-7235.5.in Guinea 158 2 Pj&s- Maximization Test (EPAfOECD Guidelines). H ; .73% w ate r,.!] .. .. Twenty-eight Day.RepeatecFDcse Oral Toxidty , 15 8 2 3 Studyof T-68S1-in Rats ' ljth iu m Bis(perfluoroethylsulfohyl)imide 75-80% ammonium [J; 7 3 % 773 2-1 8-5 13284344-8 . . .' - . com m ercial co m m ercial t>is[ethyl(perflubrooctane)sulfonayl]phosphate;;10^1 5 % Nrethy)hepta)ecaflon>N[2-(phosphoriooxy)ethyl] . ` ostarisiiifonmide; 3-7% N - '' etirylpertluorooctanesulfonamidoethl alcohol; -1-5% octansuifonamide, W,N`. N"-[phdsphiniidynetris{oxy- Fwenty-eigfu Day Repeated Dose Oral Toxicity 15824 Studyof T-7005 in Rats ' kcute(4-Hour) Inhalation Toxidty of Test atmospheres Obtained after Heating { ] or 158 2 5 1 ?oiyp*,opylene in Rets . . 2,1-ethandiyl)]iris; 1-5% fluoroaliphatic am monium coproduct; o.5-i.5% fluoroaliphatic diam m onium coprodirct . '' 75-80% 30381-98-7; 10-15% 67969-69-1; 3-7% 1691 f 89-2; 1-5% 2250-98-8; 1-5% 67939-97-3; 0.5-1.5% 57939-934 . . commercial catty adds, C18-unsaturated~dimers, 2-. ' *--98-1645 - C A S 306974-63:0 - N a m e disclosed on methyi[(perfiuor(>C4-8*alkv1)suifonyl]amino]ethyl esters SN UR . com m erdal ' TradeScret mbttre . . ione rad Secret ' >erfluf0octanesulfonamidoacetat9 (M556; T-7071.2) 15 8 2 5 fiRats' .. (>erfluoroodanesulfonamido carboxylic acid . i>806-24-8 - * ' F& D r one Final 6 September26, 2005 Revision to 121 Studies provided in Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 {Gonfidntial Business information Redacted); , .. Updated from July 15.2005 spreadsheet 0.0,07% aliphatic hydrocarbons; [ ]; 0.85% 1-methoxy-2- propanol; 2.58% 1-{2-butoxypropoxy)-2-propano!; 0.845 ethyl alcohol; 7% sobutane; 85.54% water; 0.009% methyl is'obutyl ketone; 0.186% m orpholine; 0.03S% 0.35% 107-93-2; 2.58% 29911-28-2; 0,84% 64-17-5; ammonium hydroxide; 0.048% ethyl acetate; 0.009% 7% 75-28-5; 85.54% 7732-18-5; 0.009% 108-10-1; Acute Nose-OnlyInhalation Toxtdty.Studyof T- heptane; 0.017% -2-m ethoxy-l-propanol; 0.018% 0.186%'110-91-8; 0.038% 1336-21/6; 0.046% 141-78 7087, Tr7CS8,T-7089and T-7090in Rats (Limit 1582/ Test). ' Acute ocularirritationStudyof T-7485Applied to solvent naphtha (petroleum), light aliphatic; 0.032% methyl alcohol; 0.184% sodium nitrate 6; 0.009% 142/82-5; 0.017% 1589-47-5; 0.018% 6474!? ' 89-8; 0.032% 67-56-1; 0.184% 7631-99-4; f | com mercial 15826 NewZealandWhite Rabbits . potassium nonafluorobutanesulfonate ToxicokineticStudy ofPerfluorooctarjeSulfonamide 29420-49-3 .. com mercial 1582S (PFOSA;T-713i^) in Rats ` . . ' perfluorooctanesulfonamide . PerfluroButapesulfonyl Fluoride (96-98%) And 754-91-6, '' - building block ' . 15830 Acute Four-:Hpur.InhalationStudy,in-Rats .a PffIc>ros'uIfofn-.(2^4% j' .' - . 96/98% 375-72-4; 2-4% 42060-64-0 ' ; R8D ` ............................. .. 1583.1 Rabbits . ' . n "- u- . ' R8D . potassiumj2-(3-trifluorom ethoxy-1,1,2,2,3,3/ MV31K-Salz;TestTorPrimaryDermal Irritation.in' ' hexafluoropropoxy)-2,2,3,3^tetratluoropropio[iate 15832 the Rabbit.' ......... ` .. (C7F13.0.4K)"". AssessmentofAcute Oral ToxicitywithT-7550 In . Unknown 158^3 TheRat (AcuieToxic Class Method) ` ' . " ' u V Acute Eye Irritation/Corrosion Studywith T-7560 in I], ' Z.. 15834 the'Rabbit-. ' h ' ' . .. -, : . n' ' . ,. ' ' ' ' :' ' ' '"' com mercial- : interm ediate; no t com mercial interm ediate; not com merda! Trade Secret m ixture none nne R&D ` none norie * ' ` { ) Potassiumtts-(peffiuorobutanesulfonyJ)lmlde . 15835 RepeatDoseAOMEStudyin Rats \ ToxicityStudybyRepeat Dose inhalation * . 15836 Administrationto C>;Ratsfor4 Weeks Potassium bis(perfluprobutanesulfonyf)im ide Prflurbutanesutfonyi Fluoride (96-9834) And . PerfluorosuIfolan.(2-4% ) . . " ;. : 129135-87-1'- ' . ' " ' '- ' - ' com mercial . 96-98% 375/72-4; 2-4% 42060-64-0 R&. Trade Secret ' none ' A Sub-acute{Zfi'Day) inhalationToxicityStudy, 1,1,1,2,2,4,5.5,5Tnpnafiuoro-4-(trifioromethyl)-3- . *. 15837 Induding a RecoveryStudy,-withT-7479in Rats '. pentanon : -, Xenochemicai Receptortrans-Activabonby : -15838 Rer1\ioro<xHarK>-t^erfCHemfca1s'.` " * * ' perfliiorooGtnesuifonamide ' 84%-'1toctaneSul(ofiic aeid, .. 1,1.2,2,3,'3,4,4,S iS A ejiTiS A S -heptadeoafluoro-, potassium salt; 5;5% .potassium, ' (l^uoroh9iyi)sul.fonate;4% j>otassitim ' nonaftuorobutanesuifonate; 4% potassium Xenocherfiica! Receptor trans-Activation by 15838 Peffluorcoctane-basedCherra'c^s" pertluoroheptanesulfpnate; 2% potassium SSrnuoropsitansulfri^e; 0:5% unknown 95% N^thylpertluorooctanesulfonam idoethyl alcohol; 5% l^eptanesulfortm de N^thyF Xenochemfca! Receptor trans-Activation by 15838 ^erfiuocooctane-basedChemicals . . 1 ,1 ,2,2,3t3,4t4,5,5.6,6,7,7,7-pentadecafluoro-N-(2- hydroxyethyJ}- \ . ' '. 756-13-8 ' 754-91-8' ' 'Y . - ' - com m ercial building block 84% 2795-39-3; 5.5% 3871-99-6; 4% 29420-49-3; 4% 60270/55r5; 2% 3872-25-1 ' -' Commercial 95% 1691-99-?;- 5% 68555:73-7 - juilding block Trade S e cre t ' ' ione ' ' \cute inhalationToxicokinctic Study of 58 39 3erfluoroctanesulfonyi Ffuroide (POSF)T-7098.4 cerfiuorooctanesuifonyJ fluoride -ive-DayInhalation Toxicity StudyofHFE c-701 in . 15840 daleCDRats <>C6F11-CF2-OrCH3 ' . 307-35-7 . . 8214-67-5 '*' /teute Toxicity Screenof Perfluorocyclohexene (T- 70% crude perfluorocyclohexene; 30% 15841 e878) in Rats., . serfiuoromethylcydopentene . jenzolc add 2,3,4,5-tetrachloro/6-(((3- `ro% 355-75-9 -. _ ....................... - ((heptadecfluorooctyl)sulfonyl)oxy)phenyl)amino)carbo ' .' .15842 ! J(T-7056)'T6xTcb^!nVtic Stiicfy in Rats' * "fi$)/monpiassum s a lt...... * ................. " .... ...... ' ....... )7 5 S 9 -8 5 ~ 2 .......................... " ' ' ;ommercial F& D . Ft&D ............. ...............................1 "rade S ecret- jc om m ercial 1'rade Name Final 7 L f.? September 26, 2005 Revision to 121 Studies provided in Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 - (Confidential. Business Information Redacted) Updated from July 15,20Q5$pfeadsheet N-veihyi rerfiuorobuiylsuifonamius = S5% 1 - i ButanesuJfonamlde, 1,1,2,2,3,3,4,4,4-Nonafluor-n- Assessment ofAcute Oral Toxicitywith T-7S01.3 in Methy}; 5% N-MethyM~Hydrido- 15843 the Ret (Acute Toxic Ctasa Method) Perfluorobutylsulfonamide 80-90% Sulfonamides, C4-8-alkane, perfluoro, N-[3- 68298-12-4 R&D Subchronic90-Day Oral Toxicity Study vritb T-7320 (dimethyioeddoamino)propyfl; 10-20% sulfonamides, C4- By Daily Gavage inthe Rat Followed by a 28-Day 8-alkane, perfluoro; N-^idimetftyloxidoaminoJpropyi), 15844 Recovery Period* potassium salts 80-90% 179005-07-3; 10-20% 179005-06-2 commercial 84% 1-octanesulfonic.add, 1 ,1 ,2 ,2 ,3 ,3 ,4 ,4 ,5 ,5 ,6 ,6 ,7 ,7 ,8 ,8 ,8 -h e p ta d e c a flu o ro -, Protein Binding of Perfluorobutane Sulfonate, Perfluorahexane Sulfonate, Perfluorooctane - Sulfonate and Peiftupfpoctanoate to Plasma (Human,.Rat, andjMonKey)t ard..yariqu`s. Human-. 15845 Derived Pi^maProlein Fractions - ' potassium salt; 5.5% potassium (periluorohxyl}sulfonate;,4% potassium nonafluorobutanesulfonate;4% potassium perfiupfohptanesutfonate: 2% potassium prfloropentnesulfanate; 0.5% unknow n .. . . 84% 2795-3.9.-3;..5.5% 3871-99-6; 4% 2942CM9-3; 4% ' 6027-55-5; 2% 3872-25-1 ' commercia! Protein Binding oLPerfluorobutaneiSulfonat. Perfluorohexarie Sulfonate, Periluorobctane' Sulfonateand PerfkK*ooctanoate to'Plasma (Rinnan, Rat, aridMonkey};and'Various' Human* . 15845 Derived RlasmaProtein Fractions. potassium nonafluoroButanesulfohate ' . 29420-49-3 ' . commercial fTpteiriBinding of Perfluo'rpbutane Sulfonate, PeriHiorciiexane.ilfonate, Periuorooclane Sulfonate and Perituorooctanoatato Plasma ' (Hunan. Rat and Monkey); and Various Human*-' 15845 bbrived-Piasma'Profein'FracSons . ' potassium (perfluorohexyf)sulfonate 3871:99-6 ' . . R&D . ProteinSindingof Perfluorobutane-Sulfonate, Peifluorohexane Sulfonate, Perflubroofciane' ^Ifon'ate andPerfkjbfooctanoats to Plasma . - (Human. Ratand Monkey), ?dVarious Human- 15845 Derived Plasma Protein Fractions. - potassium perfluorooctanoate FiveDay Inhalation ToxicityStudyof c-401 2395-00-8 ' ' ' R&D ' MonocWoride, c-701, and HCFC225cb in Male CD ' 15848 Rats - ` ' ' C4F9-OCH2CI ` ' 205367-42-6 fo-isomer) and 221617-86-3 (l-isomer) R&D Frye Day Iftfialatfon ToxicityStudyof c-401 MoriochJoride, c-701, arid HCpC225cb In Mate CD 15846 Rats . C-C6F11-CF2-0-CH3 . 181214-67-5 . R&D Five Day Inhalation Toxicity.Studyofo4G1 . monochforide, c-701, and HCFC225cb in Mate CD 15846 Rats ' . * CF2C1CF2CHIF 507-55-1 commercial ToxicoltirietrcScreen of FC Methyl Carboxamide (T- 15847 7483)inRats " ' . C7F15C(Q)N(H)CH3 89685-56-3 . R&D. 84% t-octanesulfonicacid, i,1,2,2;3,3.4,4,5.5,6.6,7.7,8,8,8-heptadecafiuoro-, potassiumsalt; 5.5% potassium - LowLevel Oral Perfluorooctanesulfonate (PFOS) Dose Toxicoldnefic Study in Rats: Serum and Liver ` 15848 PFOS . (perftuorohexyl)sulfonate; 4% potassium nohafiuorobutanesulfonate; 4% potassium 3eHluoroheptanesutfonate; 2%-potasstum Derfluoropentanesulfanate; 0.5% unknown - 84% 2?95-39-3; 5.5% 3871-99-6; 4% 29420-49-3; 4% 60270-55-5;.2% 3872,25-1 commercia! I. none none none- . . none rione ' . . ' : none rione none none none - . :' none .Final 8 St. Paul, MN 55344-1000 653 733 1110 October 26, 2004 By Hand Delivery Document Processing Center (7407) Office of Pollution, Prevention and Toxics U.S. Environmental Protection Agency 1200 Pennsylvania Avenue, N. W. Washington, DC 20460 Attention: Section 8(e) Coordinator Re: TSCA Section 8(e) Submissions Dear Sir/Madam: 3M Company ("3M") requests that EPA place the attached studies in the TSCA Section 8(e) docket. W e have included a master index for these studies identifying the study title, test substance and CAS number. A Confidential Business Information (CBI) version of this index and the studies also is being submitted today pursuant to EPA procedures. 3M has not provided CBI substantiation with this submission, but would be willing to do so at the Agency's request. 3M has concluded that data in these studies may not be, strictly speaking, "corroborative" of previously reported or published information as defined in EPA's reporting guidance or otherwise potentially may warrant 8(e) submission based on EPA's reporting guidance. 3M appreciates EPA's attention to this matter. Please contact the undersigned if you have any questions or require further information regarding this submission. Very truly yours, (W j Dr. Katherine E. Reed, P h D Staff Vice President Environmental Technology and Safety Services (651)778-4331 kereed@mmm.com October 10, 2005 2nd Revision to Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on October 26, 2004 (Confidential Business Information Redacted) 1st Revision - March 11,2005 8EHQ1004- Tit! Aquatic Toxicity Data Sheet 48hr Daphnia Magna Substance Information CAS Information Confidentiality Substantiation* 1.4-dioxane: heptadecaftuoro-1-octanesuifonic acid, linear n-etbyi 1,4-dioxane (123-91-1); heptadecafluoro-1-octanesulfonic acid (1763-23 Category 3 perfluorooctanesulfonamide; n-ethylperfiuorooclanesulfonamidoethyi 1), linear n-ethyl perfluoroodanesolfonamide (4151-50-2); n- In the original submission 3M alcohol; poly(oxy-1,2-ethanediyl). .alpha -(2- ethylpertluorooctanesulfonamidoethyl alcohol (1S91-99-2), poty(oxy-1,2- claimed CBI W e now release that iethyt((heptadecafluorooctyt)su1fon^)3mino)ethy})-.omega -hydroxy*, ethanediyl), .alpha -|2-iethyll(heptadecaftuoroocty)su1fonyt)amino]emyl}- claim No substantiation provided poly(oxy-1,2-etbanediyl). ,elpba.-j2- .omega.-hydroxy- (29117-08-6); poly(oxy-1,2-ethanedyt), ,alpha.-|2- {ethyl[{nonafluorobutyl}sutfonyl)amino]eihy)]-,omega -hydroxy-. |ethy)|(nonaRuorobutyt)suifonyt)amino)ethyl}- omega -hydroxy- (68298-79 poly(oxy-1,2-etbanediyl), .alpha -|2- 3); pcHy{oxy-1,2-ethanediyl). alpha -(2- {ethyl{{pentadecanuaroheptyi)sulfonyi)3mino)ethyl}- omega.-hydroxy-; lethyl[(pentadecanuoroheptyl)suifonyl)amino}ethy})-.omega.-hydroxy- poly(oxy-1,2-ethanediyl), ,alpha.-|2- (68298-81-7); po)y{oxy-1,2-ethanediyl), .alpha.-|2- JethyiI(tridecaRuorohexyt)sulfony1)arnino)eiyt}-.omega.-hydroxy-: (eihyi[(tridecaRuorobexyi)suifonyl}amii>o]ethyi}- omega -hydroxy- (56372 po)y(oxy-t,2-ethanediyl}, ,a)pha.-|2- 23-7); poly(oxy-1,2-ethanediyl), .alpha -(2- |ethylJ(undec3nuoropentyt}sulfonyl]amino)ethy)}-.omega.-hydroxy-; {eihyJI(undecaRuoropenty!)sulfonyl}amino)etbyl)-.omega -hydroxy- polyethylene glycol; water (68298-80-6); polyethyleneglycol (25322-68-3); w ater(7732-18-5) 15359A Multigeneration Daphnid Life Cycle Test 1,4-dioxane; heptadecafluoro-t-octanesulfonic add. linear n-ethyl 1.4-dioxane (123-91-1); hept3decanuoro-1-octanesutfonic acid (1763-23* Category 2 perfluoroodanesulfonamide, n-ethylperfluorooctanesulfonamidoethyl 1); linear n-ethyl perfluorooctanesutfonamlde (4151-50-2); n- in the original submission 3M. alcohol; poly(oxy-1.2-etbanediyl). .alpha.-[2- ethylperfiuorooctanesulfonamidoethyl alcohol (1691-99-2); poly(oxy-1,2- claimed CBI W e now release that [ethyl[(heptadecafiuoroociyl)sdfonyfJamino]ethy!)-.omega -hydroxy-, ethgnediyl), .alpha -f2-iethyl((heptadecanuoroociy))sutfony!)8mino}ethy)}- claim No substantiation provided poty(oxy-1,2-ethanediyl), .alpha -|2- .omega -hydroxy- (29117-08-6). pofy(oxy-1,2-etbanediyt), .alpha -|2- (elhyjfinonafluorobutyjjsulfonyijaniinojethylj-.omega -hydroxy-; fethyl((nonafluorobutyl)3tj|fonyl}arnino]ethyl]- omega -hydroxy- (68298-79 poiy(oxy-1,2-ethanediyl), .a!pha.-{2- 3); poly(oxy-1,2-ethanediyl), alpha-f2- (ethyl{{pentadecafluoroheptyl)suifonyl]amino}ethylj-.omeg3 -hydroxy-; [ethyl((perrtadecaf!uoroheptyl)suffonyl)anxno}ethyi}-.omega -hydroxy- po!y(oxy-1,2-ethanediyl). .alpha.-{2- (68298-81-7); po!y(oxy-1.2-eihanetfyf), .alpha.-[2- [ethyi^tridecatluorohexyfjsuifonylJaminoJethylLomega -hydroxy-; [athy![(tridecafluorohexyl)suffonyI}amino]ethyl}-.Ofr>ega -hydroxy- (56372 poly(oxy-1,2-ethanediyl). .a!pha,-{2[ethyt|(undecaf!uoropenty!)su}fonyl]amirK>]ethyIf.omega -hydroxy-; 23-7); poly(oxy-1,2-ethanediyl), .alpha -{2(ethy}[(undecaJiuoropentyl)5ulfonyljamino}ethyJ|-.omega.-hydroxy- polyethylene glycol; water (68298-80-6), polyethylene glycol (25322-68-3). water (7732-18-5) 15860A Aquatic Invertebrate Testing - Alkylftns LR 8024-1 15861A Aquatic invertebrate Testing - Decosheen Material (LR-8052) 15852A R Scratch Remover {Fathead Minnow) 15863A Alkyltms' rtibutyttin laurate and dibutyltin-di{2 ethylhexoate) Decosheen Ribbon Materials and pigments* Decosheen Blue in Green Ceres Blue ZV; Decosheen Gold Paste Pigment: Oecosheen Royal Blue, Solvent Blue 55-65% Water, 20-30% Stoddard Solvent; 1-5% Sodium Silicate; 1 5% Potassium Hydroxide; 0 1-3% Nonytphenoxypoly(oxyethylere)ethanol Dibutyltln laurate (CAS 77-58-7), Dibutyttin-di(2 ethylhexoate) (CAS 2781-10-4) Category 2 No change to submission No substantiation provided Decosheen Blue in Green Ceres Blue ZV (CAS 61814-09-3), Category 2 Decosheen Royal Blue, Solvent Blue (CAS 1325-86-6); Decosheen Gold No change to submission No Paste Pigment (CAS Number Unavailable) substantiation provided Water {CAS 7732-18-5). Stoddard Solvent (CAS 8052-41-3); Sodium Silicate (CAS 1344-09-8); Potassium Hydroxide (CAS 1310-58-3); Nony!phenoxypoty(oxyethytene)ethanot (CAS 9016-45-9) Category 2 No change to submission, No. substantiation provided S Scratch Remover (Fathead Minnow) 15864A 60-70% Water, 20-30% Stoddard Solvent, 1-5% Sodium Silicate; 0.1 W ater (CAS 7732-18-5). Stoddard Solvent (CAS 8052-41-3); Sodium 3% Turgitol NP-33 Silicate (CAS 1344-09-8); Turgitol NP-33 (CAS 9016-45-9) Category 2 No change to submission. No substantiation provided Octanol Water Partition Coefficient N-methylperfluorooctane suifonamidoethanol 15865A CoC!2 6H 2 0 as Co2+ Toxicity to Microtox Reagent 15924A Cobalt (as Co2+ ion) (CoCI2 6H 20) CAS 24448-09-7 CAS 7791-13-1 Category 2 No change to submission No substantiation provided. - Category 3 No change to submission No substantiation provided Activated Sludge Respiration Inhibition Test Cobalt (as Co2+ ion) <CoCI2 6H 20) cmCoCI2 6H 2 0 as Co ion 15925A CAS 7791-13-1 Category 3 No change to submission No substantiation provided Category 1: Study conla'ms chemical identity or trade name CBI Category 2: Study contains personnel and other 3M internal CBI Category 3: Study contains no CBI .1 Attachment #2 October 10, 2005 2nd Revision to Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on October 26, 2004 {Confidential Business Information Redacted) 1st Revision - March 11, 2005 M yir ra is CAS Information Confidentiality Substantiation* Acute Toxicity of CoCI2.6H20 as Co ion to Daphnia magna under Static Exposure 15926A Conditions Acute Toxicity of CoCI2.6H20 as Co ion to Fathead Minnow under Static Exposure 15927A Conditions FreshwaterAlgae Growth Inhibition Test 15928A D tphal magna 21-Day Chronic 15929A Reproduction Study Plant Growth Effects of f ) 15930A Final Report (Daphnia and Microtox) 15931A Microtox TestResults Cobalt (as Co2+ ion) (CoCI2 6H20) CAS 7791-13-1 . Cobalt (as Co2t ton) (CoCI2.6H20) CAS 7791-13-1 Cobalt {as Co2+ ion) (CoCI2.6H20) CAS 7791-13-1 ? N-ethytp#rtluorooct*ne suffbnemtdoeSienol CAS 1691-99-2 81% water (7732-18-5). 12% diethylene glycol butyl ether (112-34-5). 81% water (7732-18-5). 12% diethylene glycol butyl ether (112-34-5). I) [l Monomethyl ether of hydroquinone CAS 150-76-5 2 Ethylhexyt Acrylate; Isooctyl Acrylate Monomer; 2-Meihylbutyl acrylate; Methyl isoamyt acrylate; Isooctyt Acrylate 2 Ethylhexyt Acrylate (CAS 103-11-7); Isooctyt Acrylate Monomer (CAS 29590-42-9) 2-Methylbutyl acrylate (CAS 449.14-03-6); Methyl isoamyl acrylate (CAS 18993-92-1): Isooctyl Acrylate (CAS 29590-42-9) Category 3 No change to submission No substantiation provided Category 3 No change to submission. No substantiation is provided Category 3 No change to submission No substantiation is provided We are requesting this study be pulled from the submission. Category 1 Trade Secret Mixture Substantiation provided Category 3 No change to submission No substantiation is provided. Category 2 No change to submission. No substantiation provided. 15932A Phytotoxicity Test Results 81% water (7732-18-5); 12% dielhylene glycol butyl ether (112-34-5). 81% water 7732-18-5), 12% diethylene glycol bulyl ether (112-34-5). 11 [I 15933A PiantToxidty Comparison, Young Seedling 81% water (7732-18-5), 12% diethylene glycol butyl ether (117-34-5). 81% water (7732-18-5), 12% dielhylene glycol butyl ether 112-34-5); Growth [1 [1 15951A Ceriocfaphnia dubia Survival and Reproduction exposed to Opequon Creek BETZ 1110: Non-3M Product - Chemical composition not provided to MSDS provided by manufacturerstates productis "not hazardous" and 3M by manufacturer not "considered to be a carcinogen" . Water Spiked with BETZ 1110 Polymer (November 4,1987 sample)for seven days under static renewal conditions Category 1 Trade Secret Mixture Substantiation provided Category f Trade Secret Mixture Substantiation provided not 3M Material MSDS from BETZ provided 15952A Cehodaphnia dubia Survival and Reproduction exposed to Opequon Creek BETZ 1138: Non-3M Product - Chemical composition not provided to MSDS provided by manufacturer states product is "not hazardous" and 3M by manufacturer not "considered to be a cardnogen" WaterSpiked with Betz 1138 Polymer (November 4 ,1937 sam ple) fo r seven days under static renew} conditions not 3M Material - MSDS from BETZ provided 15953A Toxicity o ft .6 - Hexanediol Diacrylate to Daphnia magna 15954A Daphnia magna Chronic Bioassay Under Static Renewat Conditions 15955A Estimating the Chronic Toxicity of Naiclear 7177 to Cenodaphnia Survival and Reproduction Using Short-Term Tests 1,6 Hexanedio! diacrylate Methyl isoamyl acrylate Naiclear 7177 wastewater treatment acrylamide/acrylate polymerChemical composition not provided to 3M by manufacturer CAS 13048-33-4 CAS 18993-92-1 CAS information no! provided to 3M by manufacturer Category 3 No change to submission. No substantiation provided Category 3 No change to submission. No substantiation provided. not 3M Material - Nalco Ltd contact information provided 5 9 5 6 A Acute Toxicity of isooctyt Acrylate to Daphnia magna 15957A Isooctyt Acrytate Monomer CAS 29590-42-9 Category 2 No change to submission No substantiation provided. Category 1 Study contains chemical identity or trade name CBI Category 2 Study contains personnel and other 3M internal CBI Category 3' Study contains no CBI 7 October 10, 2005 2nd Revision to Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on October 26, 2004 (Confidential Business Information Redacted) 1st Revision - March 11, 2005 Static Acute Toxicity of { Jto the Daphnid, 15958A Daphnia magna Static Acute Toxicity of [ j to the Alga, 15959A Seienastrum capricomutum Static Acute Toxicity of [} to the Daphnid, Daphnia magna 15960A Static Acute Toxicity of (} to the Fathead Minnow, Pimephates promotes 15961A Sialic AcuteToxidty of [) to the Daphnid, Daphnia magna 15962A Isooctyi acrylate. Fish, Acute Toxidty Test Tolyltriazole Tolyltriarole 59% Water (7732-18-5); ( ] 59% Water (7732-18-5), [ ] water, propylene-letrafluoroethytene polymer; tert-butyl alcohol Isooctyi Acrylate Monomer 15974A Isooctyi Acrylate: Daphnia sp. Acute Isooctyi Acrylate Monomer immobilization Test 15975A Isooctyi Acrylate. Alga, Growth Inhibition Isooctyi Acrylate Monomer Test 15976A Isooctyi Acrylate: Daphnia sp. Reproduction Isooctyi Acrylate Monomer Test 15977A Acute Toxicity of3M Prep Team to the mysid, Mystdopsis baMa n-coco alkyl-2,2*-iminobisethanol; octylphenoxypdyethoxyethyiphosphate; sodium carbonate; sodium hydroxide; sodium lauryl ether sulfate; trisodium edta; water CAS 29385-43-1 CAS 29385-43-1 not 3M material - MSDS from PMC Specialties provided not 3M material - MSDS from PMC Specialties provided 59% Water (T732-18-5); I l Category 1 Trade Secret Mixture Substantation provided 59% Water (7732-18-5); ( ) Category 1 Trade Secret Mixture Substantiation provided water (7732-18-5); propylene-tetrafluoroethyiene polymer (27029-05-6); Category 1 tert-butyf alcohol (75-65-0) Trade Secret Trade Name Substantiation provided CAS 29590-42-9 Category 2 No change to submission. No substantiation provided. CAS 29590-42-9 Category 2 No change to submission No substantiation provided. CAS 29590-42-9 Category 2 No change to submission. No substantiation provided. CAS 29590-42-9 . Category 2 No change to submission. No substantiation provided. n-coco alkyt-2,2'-iminobisethano! (cas 61791-31*9); octytphenoxypoiyethoxyethyiphosphate (cas 52623-95-7); sodium carbonate (cas 497-19-8); sodium hydroxide (1310-73-2); sodium lauryl ether sulfate (9004-82-4); trisodium edta (150*38-9); water (7732-18-5) Category 3 In the original submission 3M claimed CBI. We now release that daim. No substantiation provided. 15978A Final Report (Microtox) n-coco alkyl-2,2*-iminobisethanol; octylphenoxypoiyethoxyethylphospbate; sodium carbonate; sodium hydroxide; sodium lauryl ether sulfate; trisodium edta; water n-coco alkyf-2,2*4minobisethanol (cas 6 t 791-31-9); octyfphenoxypolyethoxyethylphosphat (cas 52623-95-7): sodium carbonate (cas 497-19-8); sodiumhydroxide (1310-73-2); sodiumtauryl ethersulfate (9004-82-4); trisodium edta (150-38-9); water (7732-18-5) Category 3 In the original submission 3M claimed C B I.We now release that claim. No substantiation provided. 15979A Determination of the Partition Coefficient (N N-metbyl perfluorooclane sulfonamido ethanol; N-methyl Octanot/Water) of T-5896 by High perffuofooctane sulfonamidethyl acrylate Performance liquid Chromatography 15980A (HPLC) OECD Activated Sludge Respiration N-Dodecyltrimethylammomum chloride inhibition Test Results 15981A Final Report(Fish Acute Toxidty) Mirataine CB (30% Cocamidopropyl betaine * Amides, coco. N-(3(dimetbylamino)propyl), alkylation products with chioroacetic add. sodium salts, 70% Water and Inerts); Mirataine COB (30% Coco/Oleamidopropyl Betaine =1-Propanamimum. 3-amino-N<carboxymethyl)-N,N-dimethyh N-coco acyl derivs . inner salt) 15982A A Flow-Through Ufe-Cyde Toxidty Test With the Saltwater Mysid {Mysidopsis bahia) /1 P Perfluorooclane sulfonate N-methyl perfluorooctane sulfonamido ethanol (CAS 25268-77-3): Nmethyi perfluorooctane sulfonamideihyl acrylate (CAS 24448-09-7) CAS = 112-00-5 Cocamidopropyl betaine (GAS 70851-07-9); Coco/Oleamidopropyl Betaine (CAS 61789-40-0) CAS 1763-23-1 Category 3 No change to submission. No substantiation provided. Category 3 No change to submission. No substantiation provided Category 3 No change to submission. No substantiation provided. . Category 3 In toe original submission 3M daimed CBI. We now release that daim. No substantiation provided l i g m 1: S tu d y co n la in s chem ical id e n tity or trade name CBI-------------------------------------------------------- Category 2: Study contains personnel and other 3M internal CBI Category 3: Study contains no CBI 3 October 10, 2005 2nd Revision to Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on October 26, 2004 (Confidential Business Information Redacted) 1st Revision - March 11, 2005 Lithium: Alga, Acute toxicity Tests Lithium Chloride 15984A An Early Life-Stage Toxicity Test With the Fathead Minnow (Pimephafes promotes) Perfluorooctane sulfonate 15985A, 15986A Lithium: Fish, Acute toxicity Tests Lithium Chloride 15987A Uthium: Daphnia, Acute toxicity Tests Summary of Toxicity Testing on OSCI and OSF 15988A Toxicity to Microtox Test Lithium Chloride Octane sutfonyt chloride and Octane suifonyt fluoride Lauryidimethylamineoxkfe 15989A Ecotoxicoiogica! Testing of CoCI2.6H20 as Cobalt (as Co2+ ton) (CoCI2.6H20) Co2+ ion {Seed Germination and Root 15990A Elongation) CAS 7447-41-8 CAS 1763-23-1 .\ Category 3 No change to submission. No substantiation provided. Category 3 In the original submission 3M claimed CBI. We now release that claim. No substantiation provided. Category 3 No change to submission. No CAS 7447-41-8 substantiation provided. Category 3 No change to submission No CAS 7447-41-8 substantiation provided. Odane sutfonyl fluoride (CAS 7795-95-1), Odane sulfonyi chloride (CAS Category 3 4063-63-5) No change to submission. No substantiation provided. CAS 1643-20-5 Category 3 No change to submission. No substantiation provided. CAS 7791-13-1 Category 3 No change to submission No substantiation provided. . Category 1: Study contains chemical identity or trade name CBt Category 2: Study contains personnel and other 3M internal CBI Category 3: Study contains no CBi * Larry R. Zobel, MD MPH St 'itt Vice President and Medical Director 3M Certified Mail 3M Medical Department 7f / a r . 003 t f RETCEtVED 0 ? P f CMC 05-N0V23 RMIJ05 3M Center, Building 022(WI6-W-08 St. Paul, M N 55144-1000 651 733 51X1 Office 651 733 5152 Fax M fc 5 7 * 5 9 7 November 16, 2005 Re: TSCA Section 8(e) Supplemental Submissions: Docket Nos. 8EHO-1180-373 and 8EHO-1180-374 NoCBI Dear Sir/Madam: w 3M has previously submitted analytical results for serum measurements of various fluorochemicals. As a supplement to those submissions, 3M provides additional results as described below, oo Two female fluorochemical plant workers provided 3M with serum samples for their children through their private physicians and requested that 3M analyze the samples. A total of three children were sampled, one time each. To the best of 3M's understanding, the children were approximately 8 months, ten months and two years o f age at the time o f sampling. At the time, the workers participated in 3M's occupational medical surveillance program for fluorochemicals. This program does not include children. The sampling was done at the request o f the mothers. Worker #1 had one child sampled, in the tall of 2000, when the child was about 10 months old. The mother's blood was sampled in the fall of 1998, and again in 2000, several months after the baby's birth, as part of the regularly scheduled occupational monitoring. Thus, the maternal levels are provided here to offer some context, but they do not represent immediate pre pregnancy, gestational, or immediate post-partum levels. Worker # 2 has two children. Child A was also sampled in the fall o f 2000, at approximately age 2. The sample from 2000 was re-analyzed with improved analytical techniques in 2002 Child B was about 8 months old when sampled in the fall o f 2002. Maternal values are available from the fall of 1998, March 2000, and June 2002, and as with worker #1, are provided to offer general context. ' Sampling results are shown in the tables below. For results below the Lower Limit of S Quantification (LLOQ) o f the analytical method, the quantification limit for the chemical 5 (where available) is shown in parenthesis. m 1 033 Un --<m O p7 OCD 89060000088 906 0 0 0 0 068 09 I f- Document Processing Center (Mail Code 7407M) Pegs 2 WORKER #1 CHILD (Approximately 10 months old when sample collected in Fall 2000) ANALYTE Perfluorooctanesulfonate (PFOS) Perfluorooctanoate (PFOA) Perfluorohexanesulfonate (PFHS) N-ethyl perfluorooctanesulfonamidoacetate (PFOSAA) N-methyl perfluorooctanesulfonamidoacetate (M570) Perfluorooctanesulfonamide (PFOSA) Perfluorooctanesulfonamidoacetate (M556) RESULTS (ppm) Less than LLOQ (0.040) 0.055 0.011 0.008 . 0.007 Less than LLOQ (0.001) Less than LLOQ (0.004) WORKER ANALYTE RESULTS (ppm) Perfluorooctanesulfonate (PFOS) Perfluorooctanoate (PFOA) Perfluorohexanesulfonate (PFHS) N-ethyl perfluorooctanesulfonamidoacetate (PFOSAA) N-methyl perfluorooctanesulfonamidoacetate (M570) Perfluorooctanesulfonamide (PFOSA) Perfluorooctanesulfonamdoacetate (M556) Nov. 1998 Sample March 2000 Sample 0.146 0.117 0.069 0.338 0.026 . 0.026 0.018 0,008 0.032 0.029 Below LLOQ Below LLOQ (0.001) 0.004 0.013 Dooumrnt FroctM ing Center (Mail Code 7407M) Page 3 WORKER #2 CHILD A (Approximately 2 years old when sample collected in Fall 2000) . ANALYTE ( RESULTS (ppm) 2000 Method Perfluorooctanesulfonate (PFOS) Perfluorooctanoate (PFOA) Perfluorohexanesulfonate (PFHS) N-ethyl perfiuorooctanesuifonamidoacetate (PFOSAA) N-methy1perfluorooctanesulfonamidoacetate (M570) Perfluorooctanesuifonamide (PFOSA) Perfluorooctanesulfonamidoacetate (M556) 0.171' 0.195 0,064 Below LLOQ (0.006) 0.009 Below LLOQ (0.001) 0.008 Reanalysis of 2000 Sampling with 2002 Method 0.183 0.138 0.054 0.005 0.007 n/a n/a WORKER #2 CHILD B (Approximately 8 months old when sample collected in Fall 2002) ANALYTE Perfluorooctanesulfonate (PFO S) Perfluorooctanoate (PFO A ) Perfluorohexanesulfonate (PFH S) N -ethyl perfluorooctanesulfonam idoacetate (PFO SA A ) N -m ethyl perfluorooctanesulfonam idoacetate (M 570) 0.169 0.224 0.028 0 .0 0 8 0 .0 0 7 RESULTS (ppm) 1~ -- ---- -------------------------------' ' ........................ * Document r rocnting Center (Mali Code 7407M) Paged WORKER #2 ANALYTE Perfluorooctanesulfonate (PFOS) Perfluorooctanoate (PFOA) Perfluorohexanesuifonate (PFHS) N-ethyl perfluorooctanesulfonamidoacetate (PFOSAA) Nov. 1998 Sample 0.091 0.022 0.013 Below LLOQ N-methyl perfiuorooctanesulfonamidoacetate (M570) 0.006 Perfluorooctanesulfonamide (PFOSA) Fertluorooctanesulfonamido acetate (M556) Below LLOQ Below LLOQ RESULTS (ppm) March 2000 . Sample [2002 reanalysis] June 2002 Sample 0.161 [0.142] 0.090 0.082 [0.067)] 0.025 0,018 [0.015] 0.009 0.020 [0.015] Below LLOQ (0.004) 0.057. [0.054] Below LLOQ (0.057) Below LLOQ (0.001) [n/a] n/a 0.012 [n/a] n/a . 3M does not believe that these data meet the TSCA Section 8(e) "substantial risk" reporting threshold. In our view, these data are limited and provide no basis to draw any scientific conclusions. Nevertheless, 3M has decided to submit these data to the 8(e) docket, with the consent o f the two workers, recognizing the ongoing work by U S . EPA to assess ' fluorochemical exposure pathways and potential risks. If you have any questions, please do not hesitate to contact Dr. Laity Zobel at (651) 733-5181. Sincerely, and Medical Director 3M Medical Department.
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