Document x52ZpdOVdGLwx4n7wo71Dwzay

March 5,2007 Via Electronic and U.S. Mail Richard Irons, PhD, DABT Principal Investigator, Shanghai Health Study University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Ralph J Altiere, PhD Dean, School of Pharmacy University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Re: The Shanghai Health Study Dear Drs. Irons and Altiere: We are writing on behalf of the the scientific and clinical research being We appreciate Dr. Shanghai and (API) in support of '-HH"HE:,uU~ Health Study. unique project in worthy effort. January 29th SHS Oversight expressed for moving forward Dr. Irons. a proposal consistent with its attached this matter, and if we can assist in facilitating authorized to spend additional money to API receiving formal financial commitments from the five members Research Consortium. Additional conditions of the study being implementation of an acceptable independent Quality Assurance/Quality plan and acceptable metrics and milestones for progress and payment. API has the Draft request, Shanghai Health Study Proposed Budget for Extension and JCML Transition dated November 10, 2006, submitted by Dr. Irons of the University of Colorado. Additional funding up to $6,559,864 has been agreed to. This represents funding for the following (as described in the referenced request): Plan A Study Completion Total (Tables I and 2) $5,759,864 Plan B Laboratory Transition Personnel Proposed Budget (From Table 3) $400,000 Post Study Costs for continued publication of study findings $400,000 TOTAL $625522864 SHELL-MCCLURG-065137 Formal authorization and disbursement of these additional monies is contingent upon successful execution of an agreement between API and the research entity that will be continuing the study. Given the urgency to execute a grant/contract to continue the study, API looks forward to receiving a proposal in the near future to extend the existing grant or to establish a new contract with the University of Colorado, CynPathogen, Inc. or another entity. API Exhibits A-I to A-III, Proposal Guide For Contractors are attached; the information requested therein is necessary for of the new commitment. Sincerely, Red Cavaney Cc: C. Klaus D. Ross SHELL-MCCLURG-065138