Document x2qGgd5Q4KO4Z76Xgw60m7d1

TTrraannssllaattiioonn AArtttiiccllee cdaatteedd 2200 JJtu~nnee 22000011,,ffoouunrdoonnNNyyTTeekknniikkwve~bbssiittee. NNe~wveennvviirroomme~nnttaall ttooxxiinn ddeessttrrooyyss tthhee lliivveerr.. JooeeDDe~PiPeierrrree''ss sstutdieus oodnnmmiiicceeewwislilll ggiivveetthheeaannssw,~eerr ttoow~h,#~y,lilivveerrccaanncceerrcoocucrusrs.. WVa~lrdldwwiiddee,, rreesseeaarrcchheerrssaarreewwaammiinngg ffoorr aanneeww oOrrggaanniicc eennvviirrooffn~Tue~ntaall ttooxxiinn,, FPRRC3SS.. ~ RRIfaattstshaaennaddnmmiiirccleestthehaaattt eetaahletFPRrFeCClSIaStddeeedvveseluolobpsptaeennnclleaa,rrggePeFddOAlli,ivvedeurrsrsiaannngddatthhleeonaagnnipimrearalilssodoIotssheeey~eeiigghht.t. GadIfenevdvteehtlleoeopspatinllicimvuveleaarrlsrccLeaaenanycctdeeirtrhge[[tcthahreleellaaatutueutlhdThooosrrrussshbhsasaetvaveenencmmeii,nisssPsreefa7ddt3s&tt,hihdenetupphariannencgDrceraUeaaRtlotiEicncgaaSctpciueinynr]aaio.rrdcceetIlhtllel'sytttu~imnkooerrlssy ataththnaadStttteotthchseehtiocssnuma'lae~srUiinLssievttyrerduruiesgeitcffoyoe.rrllPPHRtFuOeQ-SnS.oi.SsrSsoorseessseaaeynyasrscJinJhooisneraDg[tta3shfeCeeinrlmererterce,h h, appne rrioosfffesetsssstshooatrrutdiincyna]b.buiisooeIcct'hhlseiemvnieliisrsktterryyly cancerinmicead ats. at Stockhel-n's University. ca~zer in mice and rats. He is researdning Ihema3hanism6 that cause liver `sFPuRFCbCSsB,t,anppceeerrsffllhuuaoovrroeooocbctetaeannneeusssuuelldpphhioonnnaiatnteed,u, stiissrynnosotitnaacenheetwhyess1uu9bb5ss0tt'aasnn.cceeW..atIItet,,r aaannnddd gootrthheeearsreffllruueooprerilinlnaeanttete,dd fttseiau-rrbreppseetrfaraiantgtouuh~rtreeihngarrevesefsioissbatemtaa,enpnntat,u,pseaaernndaddnineedxxtitnrrt=aderxu,#etsliltylyryesss,tstataibnbolcleeem,,atthttehehreei1yya9hlh5asa0vv'eusebs. beeVede~enntienpprmeeearrtnffaeedlcctgtrteriinaenasteeemvveeernertrlyy.0ttehhlBiilneungtngt,fftrhreea-nn fessitntraavebbillrefeoigrcchehhneetimt-nnigiaccanalfdlossattnterrs,uutcpcstaluoupnrreeeranaiisinsmdaaaltded ssrxahtisal~ eewscck,antconneoomwrwa~wr,te,iehsEerknnisa.lttshhSeeuusssueunbdbssyttinaanntrccnhee~etvhhaeael ssstrtbbeeeeaeem~nnwToff~oornuultn.ndddBufiinantcttethhsheeea newenvironmental toxin that isevenmore difficult envirormmt and tests on animals sho~ cencer risks. ne~venvirofl~,-,dal toxin that is evenrnore difficult to breskcbwn then CBan COT. Suddenly thewestemv~orld faces to brea~ than FEl3and ED-I-. a p1I1trwiwvaaasstwve~hcneoennnsurreletssieenaagrrccghhreeorrusspasattt atththeeedUu,nniivvienerrpssaiirtttyy,oboffyMMMiiCcchHhiIiggGaaAnnV,,SLUTSEAAT~,E [[aaacccatituueaamlilllcyysEwEoNNrIRRkIiX,n.,gIInnuc.nc,c.,er&a `tpocooroinnvattarrnataeccettwcnfofooenrrtshu33VdlMt1,i,nwovgfh~oqagosnrsoaeelu(yp(33s''isVstsla's)f)tfheEEadnlnv,vitirhrioneortmmpreaaunrntttlha,alwlbLeLyesaMbbddCdiisiHddcom~vmoeNorsestSdtoT.oAff-I2tE0thha0eec0aaabdnlearoamloytidcytsitoicwcraaoltlr]]kisinggsogoutetuaasnccadocepesrlssesss tffhorrig~aahnem mnsatew~walrllerssev,teh,lobsdbiiirronddfassnaaiannmnadadllrysesrepisnpteitaitlhrleeassttow,tAehucrerrebeaatralnulllathfrefooawusua.nnsdTddhttiiososccocwovoanentsrtaeaiedinxn. pF2PeR0FcC0CtS0eS.d. bRRsloeieosnsedceaeaorrccrthhheateitrsrsssiusffoeowuuhnsneaddrrrettphhleees tathhrhigecethrrieeecs,aatrrc~eleonssvtooeauulsirrcnceeeinsds aootfhfneaetncmiihsseissmsiinoicoeannl.a..r BBtTouuhttueeedvvh3eeiegnnnhaaaenrsneitmarseal_lelssv]ehflfrsries.amwm&srrespomaetmogxteepiellcloloteccidaaottnisiotoinhnnsscs,)e,swsuethucrachehtamaeisssasvttu~hhreeeered in ansouorrbcrttsthhitcAaA,neTcrce~iornciicntaaanniintmemsidinnblkktohaoaednn.dcdheeeIana-gnglTiceleesas.ln.. sTEE,hvveeennlheaavigehssleeesaasolltfffrlreaoovmmerlstthh,uee26pBBpaalmpltntihicc(amsseeielblaaehioheananddthemesheh)isigwguhhreerelleemvveee[loalssf~Jocorofefudrtthshineee ttgshehLerei3eyysrtaafflaanicilpleopttionuolmmaiettmsnitotibinoolonsnodatth.haaptItnatthhthuii-sas~b,:,o-ii~susstt, thh1leee.av6avepevlasrema,roagf~eaanrdiionnut~wnhooadrrtkk2eeMrprNsste:;;rdnaihalalcttvhaheoloubuDgeeehehptntthhrerheeraareessvduweroaensdseoaon[onleeflcoofurse tltghehesiinssse,wwraoaorlnkrpdkot--phuetthlmhaeeetieoggnenenneseirasraaa'rlrlplopepouogapnutulal0aa.tbti0io~o3nnt-991099..6t10hh4pippptoeeanrr,mcc,aeennantdbtiioltluehetavv5taa02llutuMeeiMmiiaessdsiaacblalxoel~usDstt]e00p..t22hppapsm-n,d,cttreeennattlilirmeoessf less, and the rn~an is around 0.03 - 0.04 picrn, about 50 t i-nes less]. ~ qI1 uvve~osuJtliIddonbbepervwoitooerrbrrilieyeddraaebbloaoututetdlleefvoveeltlssheoomffin66kppmveam~lauanensdd,aawbbeoovvheeav[[ieinntsteaeriredetssthtiianntgglwlyye,, haaalltvhteohnuoocu~h tthhee avqaosustceseisoratcisotianiatobiponornovssbewwai6btitplhhyamhhreee)ala.allttstehhadyeesfftoffJeeocclhettsseDmiiinnirnwwkoerrv.kkaeelurrssesuu, pp~,,0te.o6h6avpPe Ia~sa((idtthhetehrreaetaawrreee too few have no too few workers above 6 piton)], says Joe DePierre. ~ 4IIn1n0oo5uudrrassyttsuu.ddiieessIfttthhheeeaaannmenaslsiggeaeattvteePiiRtathOheeArrl11r00ispnpaglmma~oorlra11n0g0(:0tt3impmenFtPRhIOeKAy~OogrrePtPRcrOaSSncL[eiinrndodifeiettt]]heiinn th4lliievvtieeorrr..c5oTTdahhateeysysya. ccnaaIdfnmnotolhtotesttiaaanknkgeeimtdchaloeolsissreeessaapggtprrePeetaali:tEtteeeArsrd.ttuhhraaiInnnng11ta00h00elepepnoxpdm'jntwwthii-etintyhheodouiuthette.ccyeeagasesiitnncggatt'~ooleolrooookkfaatfhtfeteerr their coats and losing their appetites_ In the end they die. Exhibit 1940 1994400..00000011 I3MMAA00D0445522330088 ~ FRVVC~Sheacvauensntoeosttddmoionvneeeareancnayynclleoonrnggtteem~ssttuduieswdwitiithheFPRFCsCSS., BBuutt iitt iiss lliikkeellyy tthhaatt eevveenn PE2S causes liver cancer. JWooiecehDiDgeeanPe.ireTrerhee'issrtthaheetoosrrciieeosstchhaaavvneecebbreeweennheccnootnnhffiei.nymeae~tdebbyyPFaaCrrSeeosseevaarrrccahhlggorrnougupppeaarttiottdhh.ee uu[nTnihivvieserrsisisittyytoootfaflly b_EMo_RFicn~Eh_di.~go.anneFF.ioirTrnsshtcte,,airnttchhreaeertUsUannvgeiovMrteiscrcishatiintyygcaeoonrvff~SMMtnia~icctnhhei.itghgaeaMnynhaahaiatessddPdeotFnhnCeeecSnanoonovtcethhreiirnansggtlou|I nadagny~.paveOetr~irnoreeedor.oefa[f.T.shoNniNsoowtiwsehorttrokwkhtehaaalslsy. ffsboteuueondndydauai~ssesnltloiihggnadhhttctsabbntuuctterssetatxaalcMtteiissisctsthi"iiccgataalullnmlyyoSrsstsaiiwggte~nnri.eiffiic3cfaaVonnultdtndidiinantctc.hrreetoaeacsmsaeiennciiannelrllinsivetvuecedrrroyp.ttusu-ymnO,o~nrrassendriinenatsrrhacaenttsssethffrreracttarnsnv~ooeuurr vgsgietiuvvradeennyheFPissEflCGttSShhiaellirtiv.vemeddosTlltohone"neggxteecurremo((strtswsw"iicdtcueied'mtthnhroeest~sse"uukrrreivvliilvvfo"aa~ll.t~rrdhaaeattmete Tt(teo0h~enttseionerrvmanelaarsnseencccorooonnttptmrsroeyolt,lssa)a)p.,nldaaasnntthddi,e,cseiincnarnggaceetensnreser.raall,, ~ere healthier. The tu-n~rs did not "kill" then Thesewere not rnetaplastic cancers.] DIIttPiiisserpperrii-Tlnasarirtilrlyyyittnhhgeer0mreoecuhhnadaennrimists~assnbdbe,ehhOiinnndde esquffeffesotccittossn ooff1sttwhhheeyffldluouoorrliiinnvaeatrteecddelssluusbsdbteavenecl~eosptthchaaatntcJJeooree BeUierre is trying to understand. One question is v~y do liver cells devel~ cancer, ~ T]lfhiaavtetrttooixsxiiccthsse~ubbosdbtya'snsct~cclceaaaaununssseieccncgaearor'e~sgrarn,jjuuassnttdiinnhattshheetlhileivvteearsrkiisosfnnototatsksioonsgstctrraaarnneggeoe.f. TTthhoxeeic oslsiufvbuetshrtbeanissbcetytshaaveannindbdeommcdatyk~eh'isiennsgucgrlteithnal~ean.rnsninssgoolluoubrbglleaen,iinna,wn~adtteehrarsosothetthhaatattsktthheoeyyf can be taking can be transported out care of toxic transported out of the body via the urine. dB~itftfitthchueeltlliivtveoebrrcrcaeana'nkt'tdcacouopnp.eeTaarggeaayiinsnststtasysuuobsinsttaatnnhcceeesslsisvuuecrchhaaansdsPPaRrEoS~alaanntdderFFRsFOtEAoA,r,essdiinniccneetththheeebyyoadaryre'esssoo rffdoaaitttfttfayiyccauttiuslitmssiustaoeutebiinrneiatnthkhefedsastaotmr~ye.~tvTviahs~yesa/uyaesss]otaotythheeinrr organic enviraental toxins[PRSand FOAGD the liver and are later stored in the body's organic environmmtal toxins [R~ and I:~do not accu]'ulate in fatty tissue]. ~ cIInenllccsoo"nntCtrrNaaAss,ttwhttooicooththheeirsrwoohrreggtaannriiccomttooxxiinncss,a, uPPsFFeOEsAAccaGanaJcsseeerSscc(aaancnctceuearrlwwliyit,thhootuhutetrddeaainrr'aaoggmiinnaggnytthcheeases oforganic compar that cells' ENA, which is v~at of organic c~ that are otmutagenic yet can case furor to form) nomnally causes ~ [actually, there aremany are not mutagenic yet can cause tu~rs to fo~]. cases cBBeoollhlhsFPRROF3aA&ttayndaFcPRiFCdCSs~aalrrieenksswmlinitilhlaarrrettcooepnntaaotrtuusrraailnl ftfaahtetttynyuacacicieiuddssswwohfhiiccthhheaaccltitvaaessr occeomlmlmmsu.nnaiinccadattoosrerssndffoorr Vscsiiiengglknnlsaaw.llisstFh1tao0tttyhtthehaeecrcciedeeclselllpsstliontrtokoswpapneietdrhrffohor~uemnscdediipiffntffofeelrrrsueeennninttcefftuhutnenhcectntiifuooucnnnlsesc.u.tisoIIottnfoiisftshepptrrhooelibcvealebbilrvleeecrttehchleaalslttlPPsaRnFOdCS6saaennnddd PPIRCOA l inkwith the receptors and thus influence the function of the liver cells. ~ oPFFaRErAAsiinncicrsreeatashseaetssttthhheeehylIi1cvvreecrrg''sesbnrbeprecerakockxdtiuodn~eootfhfatffaat.ti.scOOrnneeeahthyeydppoowththehenseissfaaiatssistowbwryhokycecanadnnoccweenrr in occurs is that the hydrogen peroxide that is tPheelriev.ercallshassorting to dowiththe the liver cells has scrmlhing to dewith the start of thecancer. saysJoo createdvC~n fat is broken do~ start of the cancer, says Jce in DePierre. isa~ocnoohtlhhoeetrrheh1r~y.)p4o~TtohhtheeessirisseseIissarttchhhaagttrccaaaunnpicceenrrMsistctaahrrittsgsabbneecchaasuusseesetthnheetcchaaeltlllscscccnaamnnninncooatlliooonnnggeebrrecctowooeqpe3enreacrateletelwwsiitthh oehFfaaacssFhbRboeeCetrShnne-amarf.offfseTetchcdleteeedtdrees[[rtetghhaeiirnscsthssswghhorououulullddpdrrienheaaaMddeic""chctaahignniabsbnekeihaanadfsfffeosecfecteetenfedfdt"heacaantntddcadtdmeepallecrtencnndeidscrstaaootiinnontnthhceobeneccctwoeonnentceornnaeitncirteoarnalt]llsi.ioonn of I:~ - most detergents v~uld have this kind of effect at a certain concentration]. ~ WWseebemle,bserar yffllsuuDoorreiinnraatrteed.dssuubbssttaanncceessccaannccaauussee lliivveerr ccaanncceerr IinnhhLumasnsrarerraaiinnssttoobbee sere, says DePierre. ~ FwiFhriyrsscttawrweceerhhaaovvceeciuurnrscsi~tnrsamtainncddeatthhneeduudnreadtreslrlyyiinnggmmoolleeccuullaarrmmeeechhaan~ii~ms tthhaatt ccaann eexxppllaaiinn v~y cancer occurs in mice and rats_ 11994400..00000022 MA00452300 3MA00452309 eHI-nbovnmi3ar~onmmssenttthhaaaltt tiitotxiiinsss.pimoprotratanntt ttoobbeesse~snibsleiwwhhbeennlooner~ ttaallkkss babuc~tt tthh e eeffffeeccttss ooff enviror'rrenta I toxins. - Tere is reason tobelieve that nearly all chicas that are fat. soluble, and -Ihere is reascn to believe that nearly all che'ricals that are fat-soluble, and `aalileinen-t-ot-ot-htehe4-:b~oddyy ccaannbbeecacracrciinnoogcej~nniicc iinn ssuuffffiicciieennttllyyhhiigghhddoosseess.. TThheeqquueessttiioonn ishawcarcinogenaindc in rat doses. Different speciesalso react differently is hcwcarcinagenic and in what doses. Different species also react differently 1odifferent toxins. We know encugh to kn tatweshall conti toGo to different toxins. We kno~.en~Jgh to know that v~ shall continue to do reseaonrFCcBh, bt this is not the time forany alam reports research on PR:IS, but this is not the time for any alarm reports. AAu~tthho~ririttiieess aarroouun'ddtthheew~oorrlldd bbeelliieevvee hhoowceev~err tthhaatt tthhee rreeppoorrttss ssoo ffaarr aarree eennoouugghh ffoorr FCB to bo taken sriotsly. In Seckn the Enviroment ProtectionAndy FFa~ to be take~ seriously. In ~ the Enviro, f,,-,~t Protection ~ ((NNaattuurrvv~rrddssvveerrkkeett)) aanndd tthheeCChheemniiccaall IInnssppeeccttoorraattee ((KKeemmikiaklailieeiinnssppeektkitoionnen~))hhaavvee iinniittiaiatetedd a~nn iinnvveessttiiggaattiioonn ooff tthhee ssuubbjejecct.t. TThh~e iinnvveessttiiggaattiioonn,, wv~hniicchh iiss bbeeiinngg ccaarrrriieedd oouutt bbyy tthhee IInnssttiittuuttee ffoorrA/~ppql~ilieedd EEnnvviirroonrmmen~ttaall RReesseeaarrcchh ((I11MM),), iiss ppaarrtt ooff aann iinntteermnaattiioonnaall `ccooaoppeerraattiioonn iinniittiiaatteeddbbyytthheeCCEl~DD.. T[hhea aobbjjeeccttiivvee iiss t1oo ddoocaumreEnnttththeewwaeyyss tthhaatt tthhee chamcal spreads and the leves thathaveben reached in the evircment che'nical spreads and the levels that have been reached in the envirorrnmt. + FCShas broad usageand are investigating which indstries us it in their PR:S has a broad usage andw~ are investigatingwhich industries use it in their prodction. Levelsaremeasured in fish, sediamevantetr sapsmainly from production. Levels aremeasured in fish, sediT~nt and v~ter sarplesmainly fra'n tthheeSStotocckhhhooll'mnaarreeaa..WVe~aarree aalIssoo iinvnevsteigsattinigwwgesastttee wiwaantteegrr cclleeaanniinngg ppllaannttss aanndd depts, saysUIT Jamterg at (TM. In the begiming of next year MM det:asits, says UIf J~mberg at I-rM In the begiming of next year I-fly1 nicipates fo hav a gad pictur of theFRinCSvSen a~ticipates to have a good picture of the PR:B in 19~ectm. HasinaNordstra Katar ina Nordst r0-n TTeexxtt ttoo ppiiccttuurree:: FF~rec~irvedsaassvnnaateuturdraallfafatttytyacaicdidss FFRFCCS~,,CCBF8IF781C8~- RI:e~cetpotorrss iinn tthheecceellll nnuucclleeuuss lliinnkkwwiitthhththeePPRFCCBSwwhhiicchh iiss ppeercerivecdaeassbieblevolonneggiidnngg ttoo tthheebbooddyy [[wwhhiillee tthhiiss iiss lliikkeellyy,, iitthhaassnnoott bbeeeennccoonnffiirrmmeeddeexpxepreimrei'nnt~atlalyll]y.]. Fact1s Pacts 1 Difficult tobreskdown Difficult to breakdown FRcFCnRtS:Sabibenelloafnnoggrss.1toT0h2aegggrrroouuupppoofifnoocrlnguaincicoc~ roepatrhadns1tt0hh0aa0tth0h)vasveuebsiintnacnccauem,s,.lu~Rtethsheeefarafacchctetrstthhdaatot rtthoheteyy oo howcarers these are. ccntain fluor. The groq~ includesrrere kn:w how dalger~us these are. than 100,000 substances. Researchers do not FRC:EB~,,wwhhiicchhccaannrereaaccttwwiitthhbobtohthwva~tteerraanndd ffaatt [[iitt iiss sslliigghhttllyy ssooklubbllee iinn,, nnoott rreeaaccttss Wilh. vater and fat] is corpriseof acartonchainwith fluor ators lined to it with, v~ater and fat], is ccrrprised of a carbon chain with fluor atans linked to it. T1rheesuslulpphhoonnaat~eeggrorou~pa)atttthheeeennddooff tthhee cchhaaiinn iissrereacatcitivveeaannddccaannlil ninkkwwitithh ffrreeee acids,metalsand other charged groups a best 1 veldfom ton pairs with acids, rretals and other charged grc~ [at best it w~uld form ion pairs with 11994400..00000033 MACOHS2310 3MA00452310 poporosgsiaitntiiivvceeellynycvchihraaormrggeeenddtmmaolloeletcocuxulileensss,,,bFbuRutCwtSwiliislllvnneorotyt drreeiafacftci]t.c].ultIInn1oc0mabwrmeen:a~kwwidittohhwnFFCa(B~n,d,CCcOaDTnTaernnaddraooitnthheeirnr ttohhregeaeennfilcvviierrorolnvmnire(mn~tmt ff~oonrrtaaal tllooonxngigntstii,mmePedEduSurriiinnsggvwwehhriyicchdhtifthhfeiecyyuaalctcactuloTaubtlraeeteakiindn oaa~nniinmaanaldlsscaaannnddreh~ -uneaisn..in FoFuECn~B. lleIetaakksissoaulutitkeiinlnyttotohttahhteeePenFnvCviSirrsooprmTrereenantdtvsve~iennnthpperrooeddnuudcctrtssomtthheaantttccvooinnattaaoiintnthethhreescucbhls'a~timacnicacalelsbbwrrheeiaackkh l~ laattee.rrbbrItreeaaiskkddloioka/,ennlyttoothPPaFFECt SSPR[TT3hh6iissspriises,a, doosff inccoouuthrrsseee,e, nccvooirnnojjernce'tcmutrteuvaraitaet otthhthiisserpposoiuinnbtst]]t..ancesv#lich TTrraannssllaatteeddbbyyCDaavvid W idillWaian'inssflofolrr iinntteermnaall iinnffoorrrnraattiioonn wwiitthhiinn 234V.l. Merch2004 11994400..00000044 33MMAA0000445522331111