Document x1kpqxqrRX5L9GarNXD9wLM1J

April 9, 1968 Mr. Janwa /.matron Moieer Aluminum & Ohomicnl Jor.pany Trent'./ood Worka .-i>okt*ne, vauhiogton yj210 Dear Mr. Armstrong! Mr. Pogue of our Seattle oil'ice has aaked m to forward toxicity and safe handling Information relative to our fireroolotant hydraulic fluids, Pydraul 312 and Pydraul A-200. The oral toxioity of Pydraul 312 shows an LD^a to rate of 6i>00 mg/kg and it is classifiod as 'practically non-toxic" from tho acute oral point of view. When applied to the ekin undiluted mid allowed to remain overnight, a barely perceptible redness occurred, giving 0 maximum score of 1.3/8.0, which was classed as a slight irritant. The material proved capable of Leing absorbed through the skin In high doses when allowed to remain on the rabbit under a cuff. The minimum lethal doae waa somewhere over 2000 and under 3>00 mg/kg. This would fall into the slightly toxic" range. The material la a alight eye irritant when applied undiluted to the rabbits* eyes and there was mild discomfort and slight redness. The maximss soore was 13/110 and the eye had returned to normal within three days. data survived six-hour inhalation exposure to the vapors evolved nt.am&ient temperatures following the passage of air through Uhe otaterial. No systemic effects were noted. Animil toxioity studies with Pydraul A-200 have indicated that the oral lethal does (LD50) t0 rats is 10,500 milligrams per kilogram. The lethal dose vrhen the materiel was applied undiluted to the unlroken skin of rabbits is approximately r/50 milligrams per kilogram. The 3kin and eye irritation and vapor inhalation tests results wore comparable to the data for Pydroul 312. > DSW 018828 STLCOPCB4005372 Mr. James Armstrong -2 April 9, 1963 ;.e conclude from the above that accidental ingestion on the port ol' 1minens i.- not a particular hazard in view of the high oral lethal dose In rats. Similarly, single massive akin exposures should not be immediately harardouo, The lethal dose obtained in skin penetration studies is such, hov/over, that prolonged end repeated skin contact should be avoided because of possible systemic effects. In addition, prolonged and repeated akin contaot may lead to skin irritation. '.'o also feel that vapor inhalation should be avoided when the fluid is heated to elovated teraperaturea. Such exposure again relates to prolonged or repeated exposures rather than short-term massive or acute exposures. In the case of the latter* workmen would not voluntarily expose themselves to concentrations that are hazardous because of irritation of tha. respiratory tract. I have enoloeed a copy of a summary of our Interpretation of tha data for Pydraul 312. The information applies similarly to Pydraul A-200. If I can be of any further help* please let me know. Sincerely* fuacteje cci D. R. fogu - Seattle BCC: M. T. Johnson 3nclos& A. 2ramet Kelly* M.D. Medical Director DSW 018829 STLCOPCB4005373