Document x1X2Omp3OvRoKaO1YOVmzxZyG

DEPARTMENT OF HEALTH. EDUCATION. AND WELFARE.' .,'UD A N O ORiKJ ADMiN'SlfiAi lON {is \!x f, ^ Z' J^1 (Jj f/t-Je. Jar w*' //L'/ fa /^/ 20 1966 Dr. Jula Gordon, Chsiraien The Ccraittea of the Frogreaslv . Hair Bya Industry Rossis 5IG"5il j3 Scot 42ad gfcreat Kaw Yc-'rV;, k o w York 10017 Dajar Dr. Gordon: Sa'hav* completed the rev Law of the ajrporiseofcei data and other aatcrial oubsalteod by yen on Sapteabax'JL, 1965 in rapport of your request for pro" visional listing of lead eait hair colors. t&a rsgret the inordinate delay in this reply. ga have concludad that the data gubailttcd ia inadequate to deeaoaatgate ( safety of lead eslt hair c-aiorg in general or of the particular prepara tions tested. The work tows fax carried out, xethur than desoaetreting safety, raises certain questions which will require additional ` isvostigatioo. TLa 90 day rabbit intact skin study shews a nearly tenfold increase in bone lead content for the high teat levs! s against the controls. Tbs inference oust be isade that tharo Is absorption and partial ctorega of lead in the bones. However, it ia cor. clear fres the data subaitted whether the anise Is ware suitably reatrained at all time during the study. There ii therefera the possibility of ingestion frea selfgrecaing end licking of residual material off the back In which case the results of fcha study weald bo invalid. If isgaetion by self-greeting was prevented, than the only conclusion Chat can be drawn ia that there / io significant penetration through the intact skin. If this conclusion i3 valid, it would not bo in the public intercet to lict lead salt hair 1 colors. You have reported the Iced content of urine sespleo froa 105 regular users of .lead cals heir coloring products. I?s do rot, foal that the urlas load content clone is a sufficiently relie.Ho indication of lead absorption. Relatively recent reports in the literature -- PIJ3 Publication #1440, Karch 1966 for cnasplo have caused us Co reassess the typo end extent pf studies which wo believe ere necessary for permanent listing. We V* . -1 J - ,,' o, x< hava also c.-'-at: 2 ::o : '.e". ..i-t : Kor-h-vi to 2.?i.o ;<: O'- the aims wcwald b? 1 h<i 'Ss<` ~..- j i.; .1W.S :oatfem~Thor o i.'crt: e- ~ v 0 v 1 <3 it- a21 io : - " I* ': :---. ----~ 1 - .:. 3 1 - .. r : / ~ Ue baiiovs renalttf fr^s Ch-B f*XXcwinj; bafora esa bn. cevuidjrftCa orifices shoulc i>o ev'iilnr1*3 hi\i< b!>' w> AcsSt ntai tojiici.: r*)&. ikla s:ji>XicKioii - pzzcx1. . iriovf. coco retro.* tcsfcsj ov; _-, rloo--. (2C r'y'' .' '; oL `.oooic:: o.,, ...: *. &U'zb<j'h` Cii 5?&i:iZ. ihfirv rhiUiS.d ' tha & : .!/ snwsibl*. "4*. ;. if. fcLvc. coo i-:v. ere 3 t*ij* S-2Lo 5o . A>: M/Wcific.2, t.C jits c c$cyy <3&t.:.c.; * osrg&E-3 icvoohi' ij bo-Aa &rmrv ee-i 00 U-..2 y Hire;. 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