Document x1JJGdXgBzRj3EN6dqr8Erda1

DR.WILLIAM R .GERAGHTY 10-- <-CAB6w= ,ai^stMet Apr i l 1, 1938 Do c t o r Rober t A. Kehoe Labor a t o r y of Appl i ed Phy s i ol ogy Uni v er s i t y Of Ci nc i nnat i Ci nc i nnat i , Ohi o ' - Dear Doc t or Kehoe: < At t a c h e d y ou wi l l f i nd t he r eques t ed r epr i nt of t he l ead c ase. I am appr eci at i ve of your i nt er est i ng c omment on t he admi ni s t er ed dos e of l ead ac et at e. As f ar as I c an det er mi ne, t he pi l l c ont ai ni ng one gr ai n each of l ead and opi um ( whi c h i s not of f i c i al ) i s t he onl y one made by t he ma n u f a c t ur i ng phar mac i s t s and has be c ome t he ac c ept ed dos e. Os i er , 6t h edi t i on, 1906, gav e dos es of t wo gr ai ns of l ead ac et at e i n t r eat i ng t he di ar r hea of t y phoi d and f i v e gr ai ns was c ommonl y empl oy ed i n En g l a n d i n t he f i r st hal f of t he l ast cent ur y i n t r eat i ng i n t es t i nal t uber c ul os i s . Ous hny , 4t h edi t i on, gav e one t o f i ve gr ai ns. The pr ol onged us e of t he l ead enor mous l y r ai s ed t he s um t ot al admi ni s t er ed t o t hi s pat i ent and I qui t e agr ee wi t h y ou t hat i t woul d have pr oduced sat ur ni sm i n a heal t hy i ndi vi dual . Howev er , wi t h t he ex i s t i ng di ar r hea and a r es ec t i on of par t of t he i nt es t i nal t r act as i n t he r epor t ed case, l es s ened i nt es t i nal abs or pt i on of t he l ead woul d be ex pec t ed. Yet , l ower ed v i t a l i t y f r om ac t i v e t uber c ul os i s wo u l d mak e hi m mor e l i abl e t o l ead poi soni ng t han t he heal t hy i ndi vi d ual . Pl eas e put me on y our ma i l i n g l i s t f or r epr i nt s of any t hi ng y ou may publ i s h. Res p e c t f u l l y y our s , YRG: EJ 0001426