Document wro83MbopKggwRyrK323e5NXo

ALBERT C. CLARK VICE PRESIDENT TECHNICAL DIRECTOR MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W. (*l WASHINGTON, D. C. 20009 (2M> 483'^mICals RESEARCH CT 17 1377 Mr. H. R. Flammer Manager, Business Area Continental Oil Company 5 Greenway Plaza East P. 0. Box 2197, Suite 1918 Houston, Texas 77001 Subject: Vinyl Chloride Research Program - Continuation of Multi-Component Studies at the University of Louisville Dear Mr. Flammer: The Technical Panel on Vinyl Chloride Research recommends continuation of the multi-component research program on "Research Techniques and Methods of Detection and Prevention of Carcinogenesis in Industrial Workers" at the School of Medicine, University of Louisville. This research has as its objectives the design of methods for early detection, prevention, diagnosis and treatment of those individuals exposed to potentially toxic chemicals with the aim of preventing any serious injury, precancerous lesions, or the development of cancer either on a short or long-term basis. The program is designed to identify, at the earliest possible time, potentially harmful chemicals and to lead to a reduction in their exposure based on objective chemical data. Simultaneously, research is being conducted at the University of Louisville on the problem of vinyl chloride toxicity and disease developed in animal models. Studies of these types are of key importance in testing the potentially more effective methods of detection and/or treatment. Among the important phases of this overall program is the evaluation of immunocompetence systems of individuals with both short and long-term exposure to vinyl chloride and other chemicals. This evaluation is designed to aid in identifying DTH 00001332jS 2- - defective or reduced immune surveillance prior to the develop ment of malignancy. The cost of continuing this research through fiscal year 1977-1978 is as follows: I. II. III. IV. V. VI. VII. Clinical Immunology Clinical Biochemistry - EnzymicSystems Clinical Biochemistry - Biochemical Changes Clinical Pathology Microbiology Chemistry Pathology Indirect Costs Subtotal Supplemental Research Costs Administrative TOTAL $ 50,046 36,300 17,700 7,735 27,560 27,552 21,190 59,765 $247,848 24,785 24,785 $297,418 I It is the view of Panel Members that if this overall program is to yield optimum results it is important that its continuity be preserved. Work under the 1976-1977 contract will terminate during the later part of this month or during the first two weeks of November. Members of the Technical Panel urge therefore that in the event that you wish this program to continue, that your commitment be returned by October 28, 1977. Sincerely, cc: Dr. Flynt Kennedy DTH 000013327