Document wr6MGM11prr1B9J4NVj6aj7wB

mDUPaONnTagement bulletin AMIUJ7* VW.5/H01 DU PONT MOBILIZES AGAINST THE RISK OF OCCUPATIONAL CANCER Tbi company'] nptriMC* puts it in food position to moat tti* daifMfa pond try niw findio|soattMdaa(ino< (onf-term, tma-iaMt npoaara todtamicals. &- Tha naw* madia raeanlly hava givan a graat daai of atlamton to tha and acraantng of naw compound* and rtgulata tha uu of aubstancu that aaaren for oauaa* of cancar, with ip*, art toxic. Tha mduatry it concerned, ciai feeua on tha proeiam of eanear howavar. mat aoma of tha proposed raauitwg from on-tha-joO axpoaura to lawa grant too Broad authority to careinogana faubatancaa that cauaa aeraan and taat cnamieai* eanear). Chamteal company am* ptoyaas undaratandabfy may pa corv Tha Long Tarm txpeeura Haaard eamad by tfua oubife dtacuaaion. Much of tha praaant concern error Thia Wanagamonf uifitfn attampta sccupationaily ralatad eanear arou to ptaca in* proeiam m parapactfvw m a raauit of two mefdanta at othar It dlacuaoaa the raaetion of Ou Port chanticaf comoamaa in wftteh it >u and lha mas of Mduatiy to th* naw facta samp uneavarad. and it daaanoaa tha company* affort* lo Inaura a Ufa worMng anufnerunant. dlecoverad that amptoyaea had da* ralopad eanear altar long-tarm aipo- aun to eareinogen*. in ana eaaa. <myi eMorlda monomar eauaad a rara liver Ou Font la Invohwd m ttta laaua b*- tuuao it maitaa or uau a law of lha maurtat* mat hava aaan wantMad m potantlally caranogamc in human ba in**. Tha company'* lang-atandtng commitment to me ufaty of tta am- eanear fet axpoaad worUar* and In tnd othar, tha enamieaf Ola chtoromathyf athar ww found to cauaa Itmg eanear. OuHng tha long panod owi which thoaa shaoucaia war* amouceo. netthar had badn conauarad carcino pfayaaa axtandt to tha carcinogan proOtam. A* daaenbad talar, Oatarmwilng wnaa la aafa in handling earclnogana la mora dMcutt than with Du Port Mims tfwst svtetMcti eta ba handled safoty, but it is commtM to dooini down iny genic. Subatancae aueh u aanaatr* bata-napfimytanuno and benzidine wart known to ba eanear hazard* on tha job. but tha numoar or occupa tional earctnogana araa thought to ba limited. Today 17 sueataneu ara currantty aubject to worupfaoa control through govammant ragutton 0#- eauu of earctnogamcwy ogaratioo whom titty cannot bt other Undo or haxarda. Navarthataa*. Ou bant oattevee thau autMtanou can ba hands** tartly, but ma com pany >a commuted to clcalng down any op*ration whara may cannot ba. Ou dent and othar chamfca! ptodueara ana aupportlng lagtaiatfon that would ptowda addad public proaaelion by giving tha Pedant govammant additienaf powar to reouir* taattrg "Our undaratandlng a# tha ootanttal offoet* of long-term lov-ievei axpaaura to eartatn etaawd audatanaaa fa ctaarar awn a wua tun a law yaara ago." uyt annum P. Oafloaray, Jr.. Ou Ponr* amaeaor of *nyironmantal affair* -wanu taamad that aoma praviauaty uaauapaetao matanal* ara mora dangaroua man waa thought to ba ma caw* Put. at Ou Pont wa hava aavarai mwaga our favor. For example. our eoncam lor DUP 091006* DU 029073 aefety nee tad ua to tightly control ttposure to oroduets mat have toxic effects. tuen at damage to body or gana. Chemicals thatart carcinogenic iff aiao likely to have amar toxic effects. Thus, some cnemieala mat may turn out to M earemogent ara already undar tight control* aacauaa of thalr loxictty. `In iWS wa established ana at ma 'irtt industrial toxicology laboratortas in ma country, the Haakall Laooratory far Toxicology ano industrial Medicina. It haa dona autalanding work in idamifying hazards and nalping **tablian Ufa practices. A major expanlion of ma laooratory It undar way. Wa hava eaan monitoring trta health of our amcxoyaaa through periodic pnyaieaj axama linca 1915. These pravantiva maaaurat ttand ua In good stead at wa tackle the currant proO/em." The Causer Problem 'The attantion that haa bean given to ma cancer problem in ma madia may make it aaem that wa ana in a cancer epidemic." aaya Galloway, "and that the diaaaaa la inersasmg due to expoeure to the product! ot In dualry, and especially to chemicals. But tha facta grva a different picture.* It la true that cancer now cautet about one-Mth of all daatha m the U.S.. and that makaa It tha aacond leading cauaa of deadt. attar naan diaaaaa. Roughly half of ad earner daatha ara cauaad by ma thiaa hoc common forma of ma diaaaaa--cancar of tha lung, ma large mtaadna and ma breast Tha incidence ot cuoif Ik pat up, but that ststMe fcdM* cm btmiMnf The incidence of eanear haa gana up. but mat mttaMo by itaaff can be misleading. Tha (Math rata from eanoar nee increased in recant decedas for man bid not tor women. According to tha latest aneiyaia of tranda by the American Cancer Society, die death rata from ad typee of cancer par 'Od.ooo ooouittion rage sdlusted), declined 9 par cant among woman oetwaan ma period* 1951-53 and iart-73. The -ate ncrttttd 19 par cant imong mn, munly due to a large inereeae (135 par cant) m lung cancer. Thui. mcraaaaa m ma overall cancer death rata nave reaulted largely from a higher rata of lung eanear. Moat axpan* now attribute the inereeae m lung cancer to cigarette smoxmg. Tha U.S.. incidentally, it not tha world leader m cancer daatha. in a World Health Organization Hat of *4 countries it ranka igth m daatha from eanear m man, and Uth for woman. Many Watt European countries rank ahead of the U.S. Furthermore, tome lata Industnefized nations nave higher cancer rates than more Induttftalizad countries. Tha medical research community la now gradually shifting more of Ha effort toward identifying the causae of cancer m an effort to prevent it (but tha main emphasis la still on finding a cure), in me peat, research on cauaaa tended la focus on two aiaaa --viruses and tha genetic makeup are inhem from our parents. So far, viruses hava bean linked with eanear in animals, but not m man. Heredity may turn out to be implicated in cancar, put more aa a (actor that makaa a parson susceptible than aa a cauaa >fi taatt. Lately, tha attention of scientists hat turned to ao-eatled "environmen tal" causes. The term refers to cancer caused By expoeure to ad metadata m our environment not |unt meta data w tne air and water, but tuottanaa wa coma m contact with Because of diet, our lifestyles, cur occupations. Cigarette smoking la an environmental factor. Recent esti mates oy government agencies and prorata researchers variously actrfbute SO 10 BO par cant of aM eanear to environmental irausaa. but there ara Big gape m ma knowledge on whten thees aatunasaa ara baaed. Tha Ooaupauanal Nek Hew serious a proetam is occupa tionally related eanear? In one sense. of course, sny incidence of cancer *suiting from on-tne-iob hazards is very serious because it mvoivaa human suffenng and probable iota of life. Insofar a* it might have Bean cra ven tad if knowledge of the hazard wart greater, any single incidence of eanear it tragic. But the question must be ajked, how serious is occupationally related eanear in tha context of tha total cancar problem? That question s nearly impossible to answer because re search in epidemiology--me study at tha distribution of disease n human populations--has lacked data to separata tne occupational causes (tom other causae of eanear. Jonn Higgfnecn, director ot the interna tional Agency lor Research on Canear. at the World Health Organization, estimates that leas than t per cent of all cancers hava Dean shown to ba related to occupational factors. But ha also says that tha cauaaa of moat cancers ara still unknown. John waieburger. a widely known career spe cialist wild tne Neytor Oana institute, recently said that ooeupattonalfy re lated eanear was probably m the range of 1.5 to 3 per cant of all cancer death*. But ha notbd that estimates In this ires must be isrgaiy s matter of guesswork. The Rest is Hat Always a Messy tlary Tha risks do axlet and tney ara risks that something can be acne about. But irs not abasia. Ou Pom's experience bears that out in the 1930a, tha company real ized that an unusually high nominee Of bladder tumors was becoming evi dent among employsea who worked with dyes at the Chambers works m New Jersey. Largely to investigate tha problem, tha contpanv established Haakall Laboratory near Wilmington It was one ol the first vtdustry instil lations devoted solely <o studying po tential hazards posed by products. Tha bladder tumor cauaa was iden tified aa oata-neonthytamma s dye intermediate. Tight controls ware es tablished. esoosure to tha product wee greedy reduced, and medical OVP 0910069 z DU 029074 luni El monitoring of amptoyMa was oagun. Pfocaaa rOMign wu undartaKan. n tne na. Ou Pant stopped manufaeturtng the chemical targaly because it was (pit exposure could net be raittfily limited to a uM lavai when tha product reached cuatcmars' plants. Novenhetaaa, 278 ctMl of bladder tumor among CltamPars Works amptoyaaa axpcaad to tna ehamieaia Hava Bean recorded over the yaara-- manly raaulttng from expoaura dur ing a period of 30 yeari ago, or aarfiar. (In addition. 83 eaaea have bean recorded among amployeaa wno worked at another plant which Ou Pont acquired and owned during the 1930a in Wlaconaln.l Slgmflcantty, m aciantlfle. medical and mduatnai circled, thia incident at tha time waa conaidarae aomatning of a rarity, aa explained by Dr. John A. Zapp, director of Haohall Laboratory for the peat 23 yaara. "The idee that many aubatancea might be carcinogenic waa not given a great deal of conaMeratton m the aciantlfle community," Or. Zapp say*. "Aa lata aa 1992. a leading pharmaoefogiat of the Yale Univeraity School of Medicine wrote a textbook in which ha aaid that only three pure agents ware known to cauee cancer in man -- beta-naphthyiamtne. araenic and radiation." In feci adwr materials had been found to be carcinogenic. But Mile reference indicatee aomatnng of the state of actantate knowledge in thle neld at the time. in studies of new chemlcaJa. #mphaaie traditionally waa on determin ing acute toxicity, the level of ahortterm axpoeure that eaueed tdversa reactions in experkeeifl animal*. Leas attention wee ghen la ahronio toxicity, tha eflect of lew-doee expo sure over the Utedree of atperfmentai animal*. The Prebieme e> Teettng HaakaN and other laboratories now do increasing numbers of chronic toxicity studies. The bend, m part, is due to Federal legislation requiring long-term taste on ah drags, food additrvoa nd igrcytturai enamieaJa bsfor# t*y ra marKatad. !t`t also dua to tna *c*m upaurga ot eoncam ovar ctrcmogena. and Ou Pont's determi nation to identify and control this hazard. Chronic toxicity testa are quite ex pensive. They call for Isrga numcera of animals and can last two or tnraa yaar*. or mora. "The coat of doing auch a study in 1958 was more than 9100.000." Or. Zapp recalls. "Today, the cost can run five timaa that amount" Tasting for earcmogwicity is a complex matter Testing tor earcmoganicity is a eompfax mattar. One problem n sim ply the lack ot an exact correlation between animal carcinogens and hu man carcinogens. There le, however, high probability mat a substanca which causes cancer in appropriate peels* of laboratory animals may also be a human carcmogan at auflteiant dose levs!*. There are enormous technical prob lems in doing studies that pinpoint the effects ot very low concentration*-- fraction* of on* part par million, for example. But the biggest puzzle now la. what substance* should be tested tar earclnogamcity? Many thousands ot oompounoa are produced by modem industry, and all cannot be subjected to lengthy, costly testing. There are. howavar. tome indicators aa to which matanaia ara likaiy to ba hazardous. For example, it a substance has a chemical structure atmliar to that of a known carcinogen, it immediately attract* suspicion. But "guilt by asso ciation" haa ita limitations. A notori ous instance in which it did not apply was vfnyt chiond* monomer. This substance m not chemically rawed to other carcinogens and wet. in fact long regeraed aa relatively nonnazardeue. Now. loxicotogrtta are look ing cioeely at similar chlorinated hydrocarbon*. Pecent interest haa focused on de velopment of relatively ahort "screen- ino" 'ears to detemvne wnten onenecala tnouid bo -attic further On* widely used screening teat s `or mutagenicity, the aoiiity of a sub stance to cauee mutauoos -n a cell. Rapidly multiplying oaciana or yeast calls ar* used, and mutagenicity can Be established fairly quickly, it ap pear* that about 85 per cent of all carcinogens are also mutagens. On the other hand, not every chemi cal that proves mutagenic will prove carcinogenic as wail. Very little is known, in fact, about what percentage of mutagens mignt o* axpactad to cause cancer m animals. Thus, the screen could lead to wide testing of noneardnoganic sueatancaa. These ar* torn* of me difficult!#* in tracking down potential canearcausing agents. A greet deal of scien tific expertise it now being brougnt to Bear on the problem, and it taems reeeenabie to assume that tatting methods will become more tenable in the year* ahead. Ueti and Mere Usia In the meantime. Hats art being eampiled of aubetanea* met to-some degree or another, nave been linked with oaneer. One auch list contain* i.SOO sub stance*. It was pubtlahed by die Na tional matftuta of Occupational Safety and Health, a Federal agency that doee research Bui haa no regulatory power. To be on the net a substance mutt have bean associated m torn* way with cancer m mo aeranrifle literature. Ou Font's me that many of the llama should not bo included because the evidence erted a n error, I* inadequate, or > ooniradKtac By other evidence. Undoubtedly.asearch wit continue to Identify more carcinogens. At pres ent. however, whan definite proof of carcinogenicity m required, the Hats are relatively anon The American Conference of Qovemmentai indus trial Hygienists, for aaemew. lots 23 carcinogenic agenta tar arisen >t naa recommended limits or axpoeure. The list that is perhaps beer known i* trio Occupational Safety and neaitn OOP 0910070 1 l DU 029075 Administration s list of' 7 eereinogsns for wnien tnat tgsncy has issued regulations (Mary of the regulations ara based on information originally davsiopao tty industry.) Ths regulauona aim at limiting emgloyea expo- sura and raaulra monitoring of concantration lavsls m raguiatad piant trait. Ou Pont makes two and utas ona of ma ensmicait on tna list, and for* marly mads or uaad eartam others Tha two ara orooucao at cnamoart Wonts in ratativaly small units. On tna basis of its asoarianca and on publisnao studiat. Ou Pont bafiavaa tnat ona of mass, ttpha-naohthyismine. is not a eareinogan. Tha othar cnamioal idamiftad by OSHA as a eareinogan is "Moca" curing agent. a rubbar cur ing agent Tha cnamioal amytanlmina. also on tha list, it purchased for uas at Ft. Madison. Iowa, m producing Intarmadiatss for coatings, but doss not appear m tna products as sold. Tha company adltarss doasiy to ail OSHA raoulramanta in handling mass sub stances Ou Ponr* madical eurveiilance programs hava ravaatad no health programs among employees wonting with those substances. (A fourth Ham on tha OSHA Hat. beta-propiolaetone. has bean detected in leas than ionic lavafs in a cioaed waste stream at ParttaraOurg, W.Vs Ths enemies! is dastroyad in wasls treatment.) Tha OSHA list of raguiatad sub stances undoubtedly will be aasanded. Meanwhile. NlOSH and the National Cancer Institute intermit tently release to tha news madia in formation on othar aMmai that soma researchers hmre'fffthad with cancer. Ou Pesifs OoaWaa "The safety of our products and of tha people who made and uee them has always bean of tha highest pri ority to us," says Osiloway. "As a oonsaduanca. wa hava davafopad our own system for managing the earcinogan pro04ama." Whan -mate ie suapiefon that a shamicai is eareinoganIc. an imme diate effort it macs la sssees me potential hazarc trd cetermm# wnat acuon is racuirsd. Tha manufaeturing daosnmam. m cooperation with Hsixall. may determine that tha tuostanca it orobaoiy ilneed to cancer, and that further steps ara necessary. Tha first concern is to safeguard tha health of amployaaa with t program whicn may mciuoe revision of work praeticss. requirements for edoitional protective equipment, proease changes, or othar imoroveO engineer ing controls Emoloyees tra informed why such sttos ara necessary. Whin there is suspicion that a chemical is carcinofemc, an immediate effort is maOe to assess the potential hazard A program for monitoring and measuring exposure levels may al ready oa m enact, it net. tha program is instituted along with an examina tion of employee medical hiatortae to determais poaaibia adverse effects on hearth. Medical surveillance proce dures. as weM aa tha recording of ampioyaa exposures ara undertaken. Depending on tha circumstances a variety of groups employees cus tomers. approonets governmenial agencies Oder producers, tna mania --may pa notified of tna aettpna taken. And if safe handling cannot be as sured. production ie to be shut down and tales hailed untk adequate safe guards ere developed. Canytag Out the tittaai Aa William Safloway has pointed out Ou Pont has tha capacity to carry out ate program deecnbed epove. Tha process or determining whether a auPetartca may Da linked with can cer begme w.tn Haaaau Laboratory's review or cnemicali made or uaad at Ou Pent plants Tha laboratory has bean aaemsmg tna degree of haxard theea substances might present Tha assessment may be baaad on references to the chemical in scien tific stuoles me cnemical's sunkenty OUP 0910071 ifflfrivi. tiJMJ5fcg3i 'o Known c4fcnogn. or ir rtsuttft of scrMmng :au. Lflrg-artn testing reauirmg lifetime animal lasts may be molested. The growing demand for tuen studies a `.ha main rauon for tha currant oxpinsion of Haakall. Laboratory space a Being incraaaed by 70 oar cant Whan ail availasla avidanca on a chemical has seen accumulated and evaluated, the decision may oa made :o describe it either as causrtg cancer in human Beings; as causing cancer n animals; or as a suspected animal carcinogen, tne evidence being mod* erate but inconclusive. This identifica tion by 0u Pont is m addition to the OSHA list of regulated substances. At this time, nine chemicals have bean identified by Ou Pont as causing cancer in animals, or aa suspected of dong so: i. m-Toluanedlamine (MTOI, e dye in termediate made at Chambers Works. I. 3. Zinc and laad chromatae, used m making pigments frequently found in paints--but not m Ou Pool's major linee o< consumer paints. Made at Newark, N.J. 4. Sthytenethiourea onmanly a neoprene curing agent maaa at Chambers Wonts. 5. Dioxans, purchased for use aa a orient m making adhesive products at Partin. N.J, and South San Frandaoo. Calk., and precious mstal oompoeidona at Niagara Falla, N.Y. #. Beta-prooioiaciona (asa above). .7 HftMftiralhvpftOftpftQCftmidft (HMFA), ft aotvaft* used fn mftklng "KtvW aramld fiber, made at Chamber* works and uasd at tha Spruanca plant. Richmond, va a. Carbon tatraeniorlda. made at Corpus Chrtstl. Texas, uasd at aeveral other pianta aa an intermediate for fluorocarbons and "Hypelon" ynthatle rubber. II. -4 Olehloro-butana-Z (DCS). Intermadiata tor nylon and neoprene, made at Pontchartraln, La., and Vietone, Texas. Tha ataoa tatan to reduce exposure may range from setting up restricted areas where no one to allowed with out protective doming, to installing now vent and scrubber systems, to 'design mg 'he process. ^ ipecut maintenance procedures. Galloway point* cut that maasutaa tuen s tneae are notnrng naw ta Ou Pent "Wa have a tremendous amount of axpananea m handling hazardous products aafsly," ha says. 'Just to taka two examples, we've been pro ducing tetraethyl laad and chlorine for many yaars. in large ouandttoa Wa'va teamed to control tha nax and maka those products lately." Ou Pent's carcinogen analysis may induda studiaa of tha incidence ot health problama among amployeaa xposed to tha cnemtcaf. Or. Sidney Pail, apidamiclogist in Ou Pent's Madleal Olvieion, deacribaa this work: "In IMS we eauoiiahad a cancar registry, it essentially s a record of all amptoyaaa who oavaiop cancar. axeapt tor nonfatai types at sxm canear. Whan company employees as a group ara comparad to large pecula tions outside tha company mat have bean studied, there is no significant dlflararea between the emetoyoes and comparison groups." Studiaa ara also dona of employees exposed to a specific chemical, in mis type ot study, employees who have bean exposed at soma ame in me pad are followed to ate pieeent to deter mine whether they heve experienced on excessive incidence ot aome form at cancer. Or. Pall has dona one study, of Ou Font fnptoyM* wortcuig win tme tftftd cnromfttftft, m wncfi thort was soma suggestion o< a higrtar than normal incidanea or lung cancar. The data were too limited to auooon oertrute conclusion*. A multl-comoany study sponsored by members o< me industry * nearly eomotetar. and it may provide conclusive evidence aa to whether there is a problem. In another currant study oetng dona by Or. Pall, there will oe enough date to support reliable conductor's. Or Pell to studying me mooted histones of employees exposed to cntorocrene. a neoorene intermediate once made at Chamoars Worse and now mace at Victoria Taxes, and Pontenartrain, La. and uied at Pontenartrain ana OUP 0910073 S DU 029077 Loutaviil*. Ky. Recant report* in 3ovii technical literature claimed a nighar incidence of cancar among worker* inanaoprana plant, and tftaaa report* prompted the Ou Pont atudy. So far. Or. Pall sayt, tha data do not moicata a statistically significant axeaaa mor tality from any form of cancar among amployaaa aa a raault of aipoaura to cnioroorana. The atudy la eontlnuing. vmat la "Safer But ma guaatien Mill paralala. what ia a "aafa" level of exposure to a car cinogen? It la a vary difficult quaatlon to anawar. Tha problem la not the aama aa with acuta toxicity, whata aafa lavala can usually ba fully demonatratad In tha laDeratoty. "If you want ma Id gtvo you an ahaoiutaiy guarantaad level ot aafa expoaura to a eareinogan. I can do it Tha (aval la zero," taya Or. Zapp. "But that's baeausa lt*a logioaily IntpoaalWa to prova that |uat ana molscids ot tha subatance would never hava a harmful aIfact on anyone who might coma m contact with It HKIat m consider oursatm oW|*d to do is to opmti rupowiWy in tho Iftt ot th bad kmfM|o wo "On tha othar hand, wa know mat tha carcinoganlc effect la doe*-relatad." Or. Zapp says. That la, tha Inctdanca ot cancar and tha ttta It tafca* for a cancar to develop are di rectly related le m* level of exposure. Thia maana that we oan reduee expoaura to a point where earner wM not occur in a pernors'* HIM. There la evidence that are HapdanaJuM that wtm eartam mduatriffi ohandeala mat wa now know mum canear In anknaia and could expect to oauaa cancar in man. lut mars la i indication may hava caused cancar in axpeasd employees." Another parapeeiva la offered by Qalloway: "What wa consider oursalve* obllgad to Co is to oparats responsibly m m# light of the bast knowledge of hazards that wa can obtain. Fortunately, our ametoyaai are vary cooperative in tha crocsax of establishing safety procedures and may understand ma importance of following mam. They are accuatomed to ehangea In procedures aa hazards are constantly redefined. All this works m our favor." Tails Substances Act Tha Toxic Substance* Act now being considered in committee* ol Congress may eventually give the government a strong hand in requir ing manufacturers to dataet and man age ma carcinogen risk. Whan pastaC. ma legislation would give tha Environmental Protection Agency the power to require testing of aubetaneee. mcludkig teats tor earemogenietty. it would gamut the EPA to require testing and screenmg of new cnemietie before they ire marketed. Aleftsrd E. Hecksrt. Ou Pent senior vice president, recently outlined the company1* reepenee to proposed leg islation, e position aharad by many other ehamieai Arm*. '*1710 chemical industry supports additional Federal legislation on (axle suowtsnoea mm win dose the gape In present laws and offer greater protec tion to worker*, contumere wid the general public," Hsckart said. "We support Federal autnortty to require taatmg ol selected chemicals. and premarkst noUReatien or acreening of new chemleale and significant new ueae of established chemicals. W* also support the authonty to restrict or limit ueae, or ban production of ohemteal substances." Thera are two proposed bills which give me EPA broaO power to require tasting and screening of a wide range of aueetancee. Ou Pont and othera would prefer to focue efforts on sub stances mat appear te pmeant Ifl- mflcant risks. The industry is also concerned that excessively broad prsmarkel lasting and screaring require ment* could inhibit the industry1* traditional amphasra on innovation and development of new products, in tha dsvsiopment stages, ntw enemtcais are already routinely handled with great ears until their degree of toxicity it established. Ou Pont fevers, in general, a bill sponsored by John Y. McCoiliater (R.-fieb.), according to Hsckart. The McCoUister bill limits tasUng and acraaning to significant risk areas. It also requires that tha itast burden some controls be imposed to prevent or sufficiently reduca tna risk. Ban ning would taka piles only it neces sary. Consideration of me economic impact would ba required whan a substance is controlled. Tha Fora Administration has endorsed the McColbiter bill, with certain amend ments which Ou Pom finds accept able. A new bill containing these amendment* has bean introduced as H.R. 1233B. The Indaatry IwWHva The chemical Industry is initiating Ne own positive action. Ou Pont and 17 othar chemical companies hews joined to establish the Chemical in dustry Institute of Toxicology The companies have pledged about SIS million for initial costa, and a head quarter* (He haa bean selecteq near RaMtgn. n.c. CUT wM first concentrate on me carcinogenic potential or nonproortetary, widely used chemical*. The drat two to be investigated will be ethylene and toluene. Emphaaa* will be on both teetmg chemicals and on derotooing new tact methods for studying toxic ity. Results of the studies will be made public. The new institute is evidence, af me industry's ballaf mat ms hazards can be tdantfflad and precautions oan be taken to aatabiisn tats working conditions. DUP 0910073 a. cunton eotxpffi. editor room aor* ou font puiioino - whaiinoton. qclawsai DU 029078