Document wr2Rp0dzm7ro7njvDJN7GYn7d

J tm Ch micals & Polymers Dr James A Barter PPG Industries, Inc. One PPG Place - 36 West PITTSBURGH Pa 15272 USA Your ref i-- MAR Z 3 (990 U Li. 0urre' BB/BGS ICI Chemicals & Polymers Limited Occupational Health POBox4 Hillhouse Site Thornton Cleveleys Blackpool FY5 4QD Tel (0253)861444 (0253) 861632 Direct Line (0253)861370 Secretary Telex 67483 ICIPLH G Fax (0253)861861 Date 15 March 1990 Dear Dr Barter WORLD REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER (ASL) DUE TO VCM I have been informed by Susan R Howe that the VCM Panel of the Chemical Manufacturers Association will be closing this year, but she will be mgiwfcfl-ining the ASL file for CMA purposes. In view of this I am sending you a personal copy of the current ASL Register and I would like to know whether or not you wish to receive it in future? You will, of course, appreciate that I try to limit the number of copies in circulation, where practicable, because I am questioned about confidentiality from time to time, especially by Germany and Canada. I be very grateful for your help in maintaining the Register, and for information about any new cases you hear of, with details of a contact so that I can pursue the matter. With kind regards Yours sincerely Lj B BENNETT M.A. M.B., B.Ch., B.a.O. D.Obst.R.C.O.G. D.I.H. M.F.O.M. R.C.P.I. M.F.O.M. (England) enc. SL 063942 C-n #/*M>.* 'J-i : '** ' ya^*- ''\j<%.1-:, ,r-v. 7 '%' :? > -CONFIDENTIAL World Register of Cases ^6f. '< '^-' t:\~: A N G10 S'A'RC' 0 M A THE %mm: - <*v--. - j "i^''' :^. -- : '; *'****$('?* PREVIEW DATEt rl-'iv - - . fi^sfe;-?'.^.. iwsfAte4te.. t-1- ls ^nnfSNUARY^9 9 0 .................... - $,<-#/ : y;1^: :&&?:?'- :"j^---Si^^^:f*********.. 'v - !?L7' (. ' k'" "* lev ~-i< W ' .; -V .; ' -A~ * \ > r'^-v- J*> : .' t ,> s - .' .'j*S**?",**.^ v- t >if --V' " ' ,;- '- vi,*- ., ,, j .v -.-v^5r,k`. -.*i<k^ ` t V-. -V>`'A y\' ' v` Collated by:C^m$,, : -.--.Bennetty cupational Health CllChemicals and Polymers Ltd ' Wi11house Site -' PO Box 4 Thornton-Cleveleys (Telephone Blackpool FY5 400 England (Telex (Fax 0253 B6S632 J 67483 ICIPLHG) 0253 861861 ) SL 063943 LIVER ANGIOSARCOMA CASES CIRCULATION OF REGISTER CONFIDENTIAL FEBRUARY 1990 BAGSHAW Dr I M M BAND Dr P R BARRAT Dr G BAXTER Dr P BAYLAC Dr BELLEC Dr BENECH Dr M BENNETT Dr B BERTAZ2I Dr P BERTUZZI M BEYNON D W S BISHOP Dr C BORRELLI F E BRAUN Dr C L J BROGDEN M E BROWN Dr M G BYREN Dr David CAMPION Dr Catherine CARTER Dr J T CATANZARITI A CELLA C CHANCE M CLARKE Dr E A CLAYTON H CONTASSOT Dr J C DAVIES J G DELORME Dr F DEPLAN Dr F DIETZ Dr H W DOLL Prof Sir Richard DOMBROWSKI S L S DOORNBOS Dr N DRUMWRIGHT Dr J R DUPONT G EMMINGER H ERNST Dr W EVANS Dr A E J FALK Dr H FARMERY Dr K FAVRE Dr FIELDING Miss C Hydro Polymers Ltd, Newton Aycliffe, UK Cancer Control Agency of British Columbia, Vacouver, Canada AECRP, Commentry, France University of Cambridge UK Atochem, Chauny, France Rhone Poulenc, Aubervillers, France Naphtachimie, Lavera, France ICI Hillhouse, UK Inst of Occupational Health, Milan University, Italy EVC, Brussels, Belgium ICI Runcorn, UK EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Akzo, Arnhem, The Netherlands ICI Runcorn, UK Shell, An Den Haag, The Netherlands Nobel Industrier, Sundsvall, Sweden Health & Safety Executive, Bootle, UK EMAS, London, UK EVC, Brussels, Belgium EVC, Brussels, Belgium ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fons, France EVC, Brussels, Belgium Quebec, Canada Atochem, Jarrie, France B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Fund, Oxford University, UK Dow Chemical, Midland, Michigan, USA DSM, Beek, The Netherlands Vista Chemical, Houston, Texas, USA APME, Brussels, Belgium VKE, Frankfurt, Germany Berufsgenossenschaft der Chemischen Industries, Nurnberg, Germany Lever Bros, Warrington, UK Centers for Disease Control, Atlanta, Georgia, USA ICI Hillhouse, UK Atochem, Montluel, France ICI Millbank, London, UK SL 063944 FILLINGER J FINCHAM Ms Shirley FOA Prof V FORMAN Dr D FRASE R W FREIESLEBEN Dr W FRIEDEL Dr H P GAFFEY Dr W GXUDICE Dr S GOTTESMAN Dr R T GROISMAN D HILLMAN Dr D W HOWARD Dr J K HOWE Dr W HUMPHRY Dr N F JOHNSON Dr C A JOHNSON Roy N KAIPERT Dr J H KALNAS Dr J KLEIN Dr H LAGAST Dr H LANHAM Dr John LANOUZIERE Dr Claudine LAWRENCE-JONES Sir C LEE Dr F I LEESER Dr Jenny LELBACH Prof Dr WK LEVEQUE Dr G LEVISON Prof Dr D A LEWIS Dr P `LIGO Dr R N LO MARTIRE Prof N LUSS R D LUSSATO Dr Josette MALTONI Prof C MATTIUSSI Dr R MELTON B MIDDLETON D MOKKA Mr MONTESANO Dr R MOTTI Dr A A MUNOZ MOUTON Dr M MacSWEEN Prof RNM NAKAMURA Dr S OSMAN Dr J PADDLE Dr G M 2 Solvay, Brussels, Belgium Alberta Cancer Board, Edmonton, Canada Inst Industrial Medicine, Milan, Italy Imperial Cancer Research Fund, Oxford University, UK DiversiTech General, Akron, Ohio, USA ECVM, Brussels, Belgium Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany Monsanto Co, St Louis, Missouri, USA Montedipe, Venice, Italy The Vinyl Institute, Wayne, NJ, USA Electrochemical Industries, Acre, Israel Diamond Shamrock Corp, Dallas, Texas, USA University of Otago School of Medicine, Wellington, New Zealand ICI Runcorn, UK ICI Australia, Melbc ne, Australia Goodyear Tire and Ruboer, Akron, Ohio, USA GenCorp, Fairlawn, Ohio, USA Dow Chemical Europe, Horgen, Switzerland Imperial Oil, Sarnia, Ontario, Canada Dynamit Nobel, Troisdorf, Germany Solvay, Brussels, Belgium Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, France Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK ICI Runcorn, UK University of Bonn, West Germany CDF Chimie, AZF, Bully-les-Mines, France Guy's Hospital, London, UK Chemical Industries Association, London, UK Dupont, Wilmington, Delaware, USA EniChem, Milan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port de Bouc, France Institute di Oncologia, Bologna, Italy Montedison, Milan, Italy Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France ICI Duperial, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo, Japan Health & Safety Executive, Bootle, UK ICI Central Medical Group, Alderley Park, UK SL 063945 3 PAQUET Dr Christiane PATERSON Dr J C PIRASTU Dr Roberta POSSBERG Dr J PUECH Dr A M PURDHAM Dr J RAMBAUD Dr J RICHARD Dr A ROBSON Mrs D ROSA Dr HS RUTY Dr J SALG Dr Joyce A SCHIPPER Dr H SCHUCKMANN Dr F SERONNE Dr D SHAH Dr Has SIGRIST Dr J SMITH Prof Allan H SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STAHNECKER Dr E SULAIMAN Dr TACHECI Dr H TAMBURRO Prof CH TENKHOFF Dr N TEPPER Dr L B TERWIESCH Dr B THERIAULT Dr Gilles THIIS-EVENSEN Dr E THOMSON Dr D H TOMATIS Dr L TONER H P VAN DER MERWE Dr H J WALTEMATE H WEJDLING S 0 WILLIAMS Dr DMJ WILSON Prof R YORK J ZOBER Dr M A Atochem, Serquigny, France ICI Runcorn, UK Istituto Superiore di Sanita, Rome, Italy Wacker-Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada RP Recherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada Petroquimica, Salvador, Brazil Atochem, St Auban, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA CMA, Washington DC, USA Shell Chimie, Berre L'Etang, France University of California, Berkeley, USA Llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA Huls AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada IARC, Lyon, France Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenungsund, Sweden BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA EVC, Brussels, Belgium BASF, Ludwigshafen, Germany From: Dr B Bennett, Occupational Health, ICI Chemicals & Polymers, Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD England SL 063946 t t CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1990 PREFACE : ACKNOWLEDGEMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1 The 14 new cases in this Register are: France 26, 27, 28; Germany 33, 34, 35, 36, 37, 38, 39; Spain 01; UK17, US 42,43. The Spanish case is the first notified from that country. 2 The following 2 cases have been deleted from the Register: Germany 26 (Alcoholic Cirrhosis), US24 (Cholangiosarcoma). 3 There are amendments from the previous Register against cases: France 22, 23, 24; Germany 31, 32; US33, 34. 4 I thank the following for information about new cases: Drs Lagast, Contassot, Friedel, Tenkhoff, Lee, Hamill and Mr Roy N Johnson. For information about other cases I thank Drs Dietz, Fendel, Smith and Williams. 5 So far as I know the following are still alive: France 15 and 28; US33 and 36. I am grateful for information on this subject in the past year, and urgently need to be kept up-to-date, please. 6 In Table 3 I have now treated a 'cluster' as 3 cases instead of 2, due to the passage of time and the increased number of cases in the world. 7 Tables 4E to 4H have been amended, as the number of cases per factory has altered. 8 A new Table 16 has been introduced showing the number of PVC factories in the world so far as known to me. Please keep me informed of any alterations in ownership, openings, re-openings or closures (see Tables 8 to 15). 9 The initials of case UK05 have been amended to RK (not JK). It will be seen that certain cases have no initials against them. Can anyone please help with this? Some of the countries concerned are Belgium, Czechoslovakia, France, Sweden, the US and Yugoslavia. 10 CHOLANGIOSARCOMA As stated above I have deleted US24 which was a Cholangiosarcoma, not an Angiosarcoma. I have heard of another case of Cholangiosarcoma but the significance of these cases is not apparent in connection with VCM. I should be grateful if anyone who knows of any other case where the patient does develop Cholangiosarcoma with VCM exposure, would inform me about it. 11 RESEARCH Please keep me informed of all relevant research and if possible send me copies of Reports. Would recipients of the Register please pass on this request. 12 Please also notify me of all changes relevant to the Register and especially new cases, for which a blank sheet is provided at the back of the Register. FROM: Dr Brian Bennett, Occupational Health, ICI Chemicals and Polymers Limited, Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD, England February 1990 BB/BGS SL 063947 INDEX Table Sequence Re lgium Ca nada Czechoslovakia Franee Germany Italy Japan Norway Spa in Sweden UK USA Yugoslavia Incidence of Cases per annum (Table 1) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) batency Periods (Table 4A) Hist ribution ol batency Periods (Tables 4B-4K) Annual Geographical Sncidence (Table 5) U VF.U ANGIOSARCOMA CASKS (REVIEW DATE - JANUARY 1990) Page 1 2-3 4 5-10 11-18 19-20 21 22 23 24 25-29 30-38 39 40 41 42 43 44-50 1 11 1 11 t ASL Case Numbers by year of Death 1 (Table 6) 1 1 ASL Case Numbers by year of first exposure 1 (Table 7) 11 1 Western Europe PVC Producers - Start-up Dates vs ASb Cases t (Table 8) I 1 USA PVC Producers - Start-up Dates vs ASL Cases 1 (Table 9) 11 1 Canadian PVC Producers - Start-up Dates vs ASL Cases 1 (Table 10) 1 1 East European PVC Producers - Start-up Dates vs ASL Cases 1 (Table 11) 11 1 Japanese PVC Producers - Start-up Dates vs ASb Cases 1 (Table 12) 1 l South & Central American PVC Producers - Start-up Dates i (Table 13) 1 [ Australasian PVC Producers - Start-up Dates i (Table 14) i i Middle Eastern PVC Producers - Start-up Dates i (Table 15) i i Number of PVC Factories in the World i (Table 16) i i i Blank form for notifying new cases 1 ]1 i i i 51 i SL 063948 Page 52 53 54-55 56-57 58 59 60 61 62 63 64 1 mlciijh LIVER Angiosarcoma Casts - (Apview Dale : I January 1990) 1------------------ 1---------------- 1 1 | 2 |1-----1 --- | -----------------CUUJfTRY JWD ) . NAME Off | PATE OF REFERENCE | INITIALS | BIRTH | "1----------------4 i^ "11---------------- j i 1 | FIRST VC COWAN? | FACTORY | EXPOSURE HO 1 1 l 1------------------1i---------------- 1I-------------------i1----------------- 01 i |12.01.13 | Solvay | Jemepfe | 00.07.SB ii i Il 1 iI 1 ii | ii | iI t ii t ii 1 iI 1 ii 1 ii 1 ii ( ii i ii 1 ii 1t ii | il l it | i1 | iI t i! 1 i1 1 i1 1 i1 1 it | it 1 i1 1 t1 1 iI j| 1 | I1 1 "I---------------- H--------------- 02 l SR 129 09 40 | Solvay --------------l lppt j 20 OB 62 ii 1 7 DATE OF DIAGNOSIS 00.05.76 00.10.79 a AGE AT DIAGNOSIS . 63 39 9 YEARS OF 1 10 --i---------------------- --i-------------------- 1 It 1 i; | 13 | H i r1 ______________ 1__________ 1 YEARS OF DATE OF j HISTOLOGICAL | ESTIMATED j | l*J 1 i | OTHER I if. 4___________________ 1 l OTHER EXPOSURE TO EXPOSURE DEATH | CONFIRHATIOR | EXPOSURE | OCCUPATION | CAREER ) cotBrrs DIAGNOSIS 18 1 | LEVEL | | HIGHLIGHTS ! 1 ___ 1______________ 1__________ 1 1 1I J___________________ I 17 29.06.76 | Yea ( High (Autocleaner (Driller in a (Hepatic tests 1 1 |M rrs |foundry jin Ort 1974 1 j 1958-1968 ) 1(3 jra> | t#ere normal . 1 | exposed tafPoljvorter (Farmer (Retired 1 | 200 ppm |l yrs 1(15 ira) (Feb 1975 1 | for 8 hrs | |Uorh in glass |Hospitalised 1 | per d*r 1 (ind. S cbemi- |Haj 1976 1 1 and 1 (cal industry 1 1 j certainly | ! jCmplete 1 | under } 1 |ciinical and 1 j 500 pf | 1 |career details 1 | in 6 to | 1 |are given In a 1 i <*' I 1 | paper bj 1 | autoclaves 1 1 (lAiblet et aj 1 | 1968-1972 | j (in Arch. Belg. 1 | exposed to| 1 jnt. Soc., t | 50-200 ppnj 1 |Hyg. Ned. 1 | 8 hrs per | 1 |Trav. Ned. 1 1 daj In | t |Leg- 1 1 35. 1 ) (1977 pages 1 | autoclaves! 1 1601-622 1 | 1972-1974 | 1 1 1 | exposed tof 1 1 l | 50-200 pp>( 1 1 J1 1 in auto- | 1 1 i clave rooal 1 1 1 | 1974-100 | 1 1 1 1 PP> 1 1 l 1 | 1975- 50 | 1 1 1 1 PP i t 1 1 [ RETIRED | 1 1 1 j 1 Feb 1975} 1 1 i._ ----- 1--------------------- 1--------------- --1------------------------ H---------------------------- Tl 11 17 9 23 10 83 | Yea | 08.62-03. |Aulocleaoer | Fireman since |1st sign July 1 | hi 01.67 |5 yrs 5 mthspo 11. |79: Thoracic | -10.H > |Operator f Ipain 07.79. | 200 ppm (3 yrs 9nrths. \ |Hepat)c tests | flh/daI I |altered 10.79, | 04.63-12. | j 66 < 200 | |Posit ive jH-hography I PP I |ll.79. Hepa|tpctctny 02.80. |rfr*wr>t herapy. {Infurwt jot [given in Iptter 12 Nov 1984 Itcu Dr Hc> Sltiover. SL 063949 cum Sheet l ------------- 1------------------ j 2 I1 COUNTRY AND REFERENCE HO NAME OR INITIALS HATE OF BIRTH CANADA 01 IS.12.13 06.03.M 26.00.19 04 05.04.19 07.05,11 LIVER Angiosarcoma Cases - {Review Dale: 1 Jan 1990) PAY - BOOTH - YEAR All dates use tilt syste 8I 10 11 | 12 13 FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL 14 j IS j H----------------1- OTHER | CAREER | HIGHLIGHTS | 16 SHAtfDflOAH 1944 19S5 1943 1957 43 02.09.SS Yes 21.12,57 I I Reactor Operator JStaoker cleaner polymerisation| Maintenance, Operator H----------- (Worked nil!wright, |overtLae pipefitter | Smoker 1941 20 23.03.62 Yes 1945 1967 40 22 22 21.01.68 Operator, foreman Reactor cleaner Reactor cleaner (Worked (overtime |Non-sucker Operator, 4- |Worked foreman, (overtime water cooling |Smoker unit | + Water cooling (Worked unit (overtime j Stoker 15.12.19 1947 1971 24 10.04.71 Yes 07 09.11.19 13.05.20 1946 1972 53 25 24.12.72 I +I 1961 12 05 (12.06.73 19.07.21 1946 J____________ L_ 53 26 04.09.74 I Reactor cleaner Maintenance, millwright | Worked {overtime (Smoker Reactor Machine shop (Worked cleaner operator and (overtime Reactor poly unit Maintenance |Smoker + jin plant cleaner machine shop (25 yrsl Smoker Furnace op. + (Worked pipefitter lovertime maintenance ( jSmoker _____________ L_ Paper by Dr F DELORME In Annales d'Anatomie patbologique Paris, 197B Vol 23 No 2 pplOS-114 claims this case had both a hepatoma and ASL simultaneously. SL 063950 Pago DAY - WORTH - YEAR CANADA Sheet 2 LIVES Angiosarcoma Cases - (Review Date: l Jan 1990) All dates use UK system 1 "1 ---------------- 1------------- ---- i |2 3 A |5 & 7 8 I 1 ____________ __________ 1I____________ _____________ COUNTRY AND | MAKE OR DATE OF 1 FIRST VC DATE OF AGE AT REFERENCE j INITIALS BIRTH COMPANY FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS HO | _____________1 _________1 _________ CANADA 1 l 10 j 1 16.05.15 | 1 Shawlnigan 1953 1976 61 Ii i r 11 | LG i 13.10.25 I __________ if________ 1 1 Gulf Shawinigan 1943 1 Nov 85 60 11 11 11 1 11 12 | BC 1 1 ______________ 1____________ J 14.09.20 Gulf Sbavinigan 1945 Nar 82 61 I1 l1 l1 I1 l1 t I 1 1 1 1 1 1 13 | SS 10.06.26 BFG Niagara 1957 1987 | 60 1 j Uelland j l1 11 1 11 ii 9 TEARS OF EXPOSURE TO DIAGNOSIS 23 42 37 30 ---- 10 n 12 TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL H OCCUPATION 1 15 | 16 i --------------------1--------------------- OTHER | OTHER CAREER j COWEHTS HIGHLIGHTS j 1 14 00.04.77 Yes 5 05.04.86 Yes Reactor cleaner High 1943-47 furnace op. alotenance, packaging Retired 1972 1 {Ex-smoker | | 1 i l |Letters frr* Operator 6 (Age 47) |Dr Fernand 27 31.03.82 Yea High Supervisor VC Plant 1945-55 Retired 1972 fDetora, | Pathologist & 1* Bibeau, BFG I1 |Letters frcm Autoclave Operator, PVC Resins (Age 52) |Dr Fernand |Delorme, | Pathologist & \k Blbeau, BFG Low 1955-65 VC Manufacture ttediia 1965-72 Autoclave I i l |1 I i Operator, I PVC Resins 1 | i 23 26.1.87 Yea 1957-70 Poly Cleaner Retired 1980 (information High A Operator (Age 54} [from (Dr H W Dietz, | 1970-80 Supervisor |8FG, 1988 ii Low ri 1 t1 I I I i l I t I ____________ i_________ i i i i i i i i ____________ t_____________ ii it ii ii ii ii ii ii ii ii it ii ii ii : ________ ii ii iiii i i i I i i I l i SL 063951 CZECHOSLOVAKIA UVEA Angiosarcaaa Cases - {Review Date: 1 Jan 90) COUNTRY AMD REFERENCE NO NAME OR INITIALS DATE OF | BIRTH CCH*ANY CZECHOSLO VAKIA 28.06.26 State Co FACTORY FIRST VC EXPOSURE 01-07.57 DATE OF DIAGNOSIS 24.12.73 fl AGG AT DIAGNOSIS 45 -- -------------------! 9 io | ii 1--------------------------1--------------------- | 12 | n 11 11 11 TEARS OF TEARS OF | Dm OF | HISTOLOGICAL | ESTIMATED EIPOSUBE TO EIPOSWE j OUTH j COHFIRmnOH 1 EIPGSIM DIAGNOSIS j| | LEVEL 1i i 1 i ll l 14 OCCUPATION I | | j I [I I lt i Il l 16 16 |24.12.73 | Tes | Autoclave Cleaner 15 OTHER CAREER HIGHLIGHTS 16 OTHER OCIfENTS IARC letter of I-4-B2 giving details fm Prof A David of Centre Ind ttjgieoe and Occ < 06.07.27 Kovakj 15 26-11-64 Autoclave Cleaner | | IARC letter of 1-4-82 gave sonewhat altered dates for this case. I have accepted the changes since the dates cone frtn Prof A David of the Centre of Industrial Hygiene and Occupational Diseases. Nf dates case originally fron HI0SH. SL 063952 FRANCE Sheet 1 --------------------------1-------------------- 1 1 |2 345 1| | COUNTKV AMD | NAME OS REFERENCE | MITCALS NO | 1 i oi |n 1 i 1 1 i1 02 |sm 1 1 1 1 1 1 DATE OF BIRTH OOHPUT FACTOR? 15.04,24 Rf Rouss illon -- 03.06.11 PCW Rrlpmd ----------------------1---------------- 1---------------1-------------------- 03 |mv 106.01.20 1 RP St Fooe 1 It 1 11 I 11 1 11 1 11 t 11 ---------------- 1-------------- 1-------------------- 04 ICR 127.01.27 | Pane Brignoud 11 11 11 11 11 11 1---------------1 1------------------- 05 B 29.oi.3s | pair Brignoud i 1 1 l 1 1 1 1 1 1 1 1 LIVER Anglosarocae Cm - (Review Date: 1 Jn 90] ---------------------- 1---------------------6 7|8 | * FIRST VC EXPOSURE Din OF | AGE AT DIAGNOSIS | DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS 10 TEARS OF EXPOSURE n DATE OF KITH 00.01.46 18.02.67 ) 43 21 19 19.02.67 1 1 1 1 1 06.07.59 1S.01.75 63 16 12 24.01.75 00.00.46 15.01.75 55 29 , 29 29.06.75 19.10.49 16.01.76 49 26 26 04.01.76 18.01.65 13.05.76 38 11 11 13.05.76 L_ 12 HISTOLOGICAL CONFIRMATION Tes 13 ESTUUTHI EXPOSURE LEVEL High ----------------------- 1---------------------------1------------------------------- 14 | 15 | 16 1I 11 | OCCUPATION j OTHER CAREER | OTHER \ CONBNTS | HIGHLIGHTS j Autoclave j 1 | \ i |taT. tavlar et verier aod 1 claaoar | |al Arch* Hal. jprof. 1 30 n' Tea (HIOSH no er--nnt) Ta Tes 19 yra [ | |3 Hov 75 jp 171-177 Hl<* 2 frs oa 11 I Italian |ltef. origin |G Bonnetoii et 10 yra on |al "Roovella polyner- tpresse leatloo |*adicalen |5 Not 1977 High Polfworkarr 10 jn as autoclave |p 135 1r VCX production|Ref. Rety et 16 frs. |al Arch. Hal. Italian POW. jprof. 1 37 a cleaner, Shepherd, J6 Jlh 7? Ca^xxndiog Sawyer, Mason |p 551-555 3 ire _______ _______ rn ] High Manor l I 1 l i production I I worker l I B ITS. I i PVC l I filtration I 18 frs i l 1 i------------------------------------------------- Tes High Polfwrksr IJThoraaotany Ref. P Ccudere 11 fra 9th Feb 1976 et al "Tfnlnr costal des hospltaux anglosarccae 10 Sept nefcro 2)Scintigraphy 1976 found ASL Previously had 3)Haeaorrhage bone fron ASL anglosarocaa*1 4)Rlght Also Hepatectcoy Pilichovdtl et al ,TL* Ncuvelle Freese Nedcaler 7th July 1979 Page 2485. SL 063953 Page 6 FRMCE Sheet 2 country AH) REFERENCE NO HAKE OR INITIALS DATE OF BIRTH 14.04.34 07 GIN 26.04,27 01.04.34 09 RFI 06.10.14 LIVER Angiosarcoma Casas - (Review Date: 1 Jan 1990) covin RCUK Solraf T-------------------1 5 6 FACTORY FIRST VC EXPOSURE Brignoud 01.03.M i i i i i i i i i i-----------------1st lubw i 1 I 01.07.50 Tavaux -- 23.05.57 78 9 10 11 12 DATE OF AGE AT DIAGNOSIS DIAGNOSIS J YEARS Or EXPOSURE TO DIAGNOSIS TEARS OF DATE OF HISTOLOGICAL EXPOSURE DEITH CONFIRKATIOi 1 11 12.08.76 1 I 1 1 1 1 1 18 1 After death inOSH says 00.07.76 49 26 I I l l 13 11.09.76 | (inosh Yes lT (12.09.76) 1 1 1 1 I 1 11 1| 22 02.07.76 Yes i (ptiosh no i coMeat) i 00.12.75 42 191 1 19 30.01.77 1 l l l J Tes ---- 1 13 14 1 is 1 ______________ 4l_________________ ESTIMATED EXPOSURE | OCCUPATION | OTHER CAREER i j on! CCMttHTS LEVEL Moderate | J 1 (1958-1960) 1 HIGHLIGHTS |lhis nan had 2 ITS l |AOL prior to filtration l |AS. Ann. de 10-H jra l polfworker l |Mal. Prof. jjuly *77 and works l (p 645 & 6. j lab? l l |*0L was found jin 1971 five l (yrs before l |asl ______________ _______________ j-------------------------- l High jPlant fore- |l972-6 acfein (Died of an In |sect Ion In |septicaemia IpolpKT- |St Kuban | Small liver lsatloo I (lesion found l |after autopsy _______ --j-------------------------lI Moderate |6 fn packer) (Had been |& autoclave I |twnel worker |clnr I (previously 14 irs I autoclave i worker l -1-------------------------- RP St Foos io.01.4a 26.04.76 63 28 28 25.12.77 Yes Very High Polymer- J10 yrs In (Operated 4.76 11 1948-1966 tsatloo ]sulphuric |for removal of 11 Lesser operator. |acid factor}, | timour from i 11 Exposure autocleaoer, (storekeeper (liver and i 11 1966-1976 autoclave (general (died after i 11 alnteoance (services (second i 11 i (surgical i 11 j |1 i (operation for i jbfllo j |1 i (bronchial j |1 !( (fistula i |1 1i (paper by j |1 [i (Dr Rety et al j l| 1I (in Archives de 1 || 1i |Naiades 1 j| 1i (Professionals | j1 1i |Vol 40 No 6 1 |1 1i |1979 pages I |741-3. I J ___ _l____________ I J________ SL n06f^39955*4t _J___________________ Page 7 FRANCE - Sheet 3 LIVER Aogloaarocae Case* - (Review Date: 1 Jan 1990) 1 12 I 13 I 14 cotnmtT m> REFERENCE HO HUE Oft firms DATE OF BIRTH ooffurr FACTOR! FIRST VC EXPOSURE DATS OF DIAGNOSIS AGE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL cnrannc* ESTIMATED j EXPOSURE j OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS OTHER CCITOTS 10 24.05.19 RP 15,02.12 10.01.78 21 21 10.01.78 Tee High Autoclaw 10 ;ra In Died of |cleaner ecbanic&l pulnonary engineering eobollse 5 lndustrf 1946-1956 day after surgery 00.01.41 12.08.7B 66 13.11.78 High 4- {1941-1946 Ipolieer- |lBBtlOO |generaI 16.08.14 PCM Brignoud 00.05.79 19.01.31 Solvaf Tavaux 23.09.63 26.06.79 05-04-24 Chloe Chiaie (Fonerlf RP) 00.07.81 J___________ I____________ L. 65 30 23.06.79 Tee 13 22.08.79 i i i i i i i i I 36 29.07.81 Tea SL 063955' High (production {and paljvarjlsstlon operator i (&utoe leaner |2 yra as cycle jcigarette i |2 I", laechanic. fsaoker until i | Auto-- |10 yrs as |1974. Ill all i lafuratar lenoaeller In jof 1977 due to i |9 [sanitary ware |Oesophageal i |CG|lot|VR jaaoufact lire (varices. i |4 rr 1 |Surgical i1 1 | Intervention t1 1 |25.05.79 i1 I |(right il I |hepatectony) Very High {1943-1975 |1975-1979 1943-1975 j 111 type* of Inlntenance and |^obs on |work Interaitt-|eanufacture | ently |& ealntenance 1975-1979 jin VCH Poly | | Process | Page 9 FRANCE Sheet 5 -- 1 11 1 -- 1 2 conmtT md | NAME OR fteraaKi INITIALS HO FRANCE 19 HAL LIVER Angtosarccaa Cwm - (Review Date: 1 Jan 1990) ---------------------- 1------------------ 1-------------------- 1 " " ""1 ------ -- 3 4 56 7 s _________9 10 11 12 n 14 15 1 16 _______________ 1 1 DATE Of SUTW 15.12.32 conn Atocbea FACTORY FIRST VC EIFOSDH DATE Of DIAGNOSIS Brignoud 07.04.59 28.10.84 AGE AT DU9K)SIS 52 TEARS Of EXPOSURE TO DIAOKBIS 25 TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL JUMPIMUTIOR 25 06.11.85 Yes Esrpnmi EXPOSURE LEVEL HI* OTHER i OTHER OCCUPATION CAREE* ! camrs HIGHLIGHTS j _________ 1 Iffocardlal Autoclave Infarction operator and I960.Coronary cleaner bypass 1981. Letter frca Dr Cantassot 5.4.86 1------------------------- 20 SR 02.03.23 Rtocbea Bripraxl 1951 27.12.85 ' 3 34 22 36.12.85 Tw - High Portal Autoclave In other parts flbroai* free operator and of factory 26.04.74. The cleaner since 1946 illoeas was dlepaeed as premaablf work related on 20.04.74. Letter frca Dr Contaaaot 05.04.86 21 Pa 01.10.40 RP SEP 1959 03.06.86 45 Nontlucoo j 27 [ 1 hr~ 22 13.08.28 Atocbea St Aaban 01.09.58 05.I1.S7 59 1 1 l ii l 1 j1 1I 23 DO 07.02.2J Atocbea St Fans 1949 1988 1 1i I 11 I1 1 l 11 t| 1 l ! SL I 0639.56 _______ 29 44 4 28.06.86 Yes j High Autocleaner Maintenance 4 fears worker Hepatic test Naf 84 noreal. Hepatic test Naf 86 showed afcooraalltles. Letter froa Dr Barrat 18.07.86. 26 0S.09.S6 Yes H14 12 fears 1958-70 Autoclave 1 worker. I .1 Low |M fears In 1f 1l [21.09.89 11 1 1I 1 1! Yes | 1970-84 [Control Roca ; High 1------------------------ [Autoclave jCleaner & | i jail PYC [ |production [ 1 11 | _____ _________ [jobs j j _______ Letters frca Dr Contassot, Atocbea 2.12.87, 29 7 88, 24.01.89 (partial |Hepatectcay, Apr |$S, Cheaotberapf | lnforaatloo frca |Dr J C Contassot, jAtocbea, 1988/89 Page 70 France Sheet 6 LIVER Ingiosarcoaa Cases - (Review Dalai 1 January 1990) -- 1 1 2 3 ---------------------- [-- 45 6 7 8 9 10 ii 12 13 14 15 16 couimti ud REFERENCE NO NINE OR INITIALS DATE Of BIRTH CMMH7 mctost FUST C nPOSORE TORS or pm or UE IT OTOSOtt THUS OF ouonsis DIAGNOSIS TO nposoM DIAGNOSIS nit or DMTTf KUTOUOSICU. EsrmtTCD onrnmnoa EXPOSURE OCCUPATION LEVEL OTHER rum HIGHLIGHTS OTHER UfBJTS 24 m D8.12.2S Itocbe* Brlfpood 1943 3968 62 45 35 01.12.88 Tea High PVC Predict on Liver transplant Nay 1986. - 2 r*ara Intonation fra Dr J C Cootasset, NCV Detectlca Atoebaa, 1988/89 - 3 years PVC Product! on Maintenance - 30 years ______ 25 BB 02.03.30 Solve? Tavaux 1962 1988 58 26 23 07.05.88 Tea 11 years) Polycleaoer High) - 5 years Polyfloor - 6 years 12 Tears Control Roca , Urn - 12 years Prlsary Liver Tiaour Nataataaes lung, brain, bona, spleen, kidney. Infomatlon fra Dr K Lagast, Solvay, November 1988 26 NO 29.11.40 Solvay Tavaux 16,04.63 25.10.68 48 25 15 02.11.88 Tea High Autoclave 12 rears Cleaner Low Tor 15 3 rears yeara Died by haeaorregtc rupture of the tinour. No surgery. Letter fra Dr K Lagast, Solvay, 28.4,89, 27 RC 1929 Itocbea St Pons 1951 1988 59 1 34 30 00.01.89 Tea 1954-74 Autoclave High Cleaner and 1974-84 all PVC Low productloo jobs Notified by Dr Cootasset, Atocbea, December 1969 28 | JG 1926 Atochee St Fona 1942 1989 63 11 1 11 i 1 47 20 Ulm Tea 20 fevi ID years High analysis (lsbs) ID fears production PVC Notified by Dr Contassot, Atocbea, Deceaber 1989 1| i__________ 1 SL 063957 Page 1 I GERMAN? Sheet 1 -- -- --------------!---------------------- 1 1 2 34 5 ---- COUNTS? AND RUE OR am of REFERENCE INITIALS BOTH NO COWRIT FACTOR? GEMOT LIVER Anglosaraaa Com - (Ravlau Data: 1 Jan 1990) 67 8 -- 9 10 11 12 13 FIRST VC EXPOSURE DHI OF oiftonsis RGB AT DIKXSIS TEARS OF DIAGNOSIS TEARS OF DHI or DEATH nSfOUGICIL CONFIRMATION ESTDQTCS LEVEL ---- 14 15 16 OTHER OTHER GCCDPATKM CAREER 009075 HIGHLIGHTS _________ _________ 01 oo.oo.x 4 4 01.10.56 19.09.68 38 12 12 25.01.69 T (NIOSH) Polprcrtw 02 00.00.31 4 A 14.10.57 25.09.70 X 13 H 14.12.71 Tea (NIOSH) Polyworker 03 00.00.30 12 12 09.06.52 00.00.73 - 1 1 1-------------------------- -- -- 04 1 1 l 1 1 l 1 1 1 l 1 1 oo.oo.x B S 16.04.57 26.11.74 J______________ t 1 1 1 1 43 21 44 17 l 16 12 i 10.10.73 Tea (NIOSH) 25.11.74 Tea (NIOSH) 1 Filling pesticide aerosol cans with VC 200-500 pfm Poljvorfeer t 1958 ns but U0I twimiry antocleaner during 1 fr aotoclnwnwr for 1 jt autoclaaoar Reported under non polynsrisatloa workers In NIOSH list of 31*3.77. This of course is strictIf correct. However I wonder whether this lean had high exposure to VCH In his can filling operation? 1----------------------- l | Clinical | details is Ipaper br |GoAal et al Vircbova Artb 1 Path 1976 1372 P 195-203 1 1t _____________ l 1 1 1_________ ______________ i I 1 1 1 i i SL 063958 Page 1 GESKHT LIVES Angiownrrr-- Cams - (Review Date: 1 Jan 1990} Sheet 2 ------------------ 1 ---------------------- 1 ---- 1 2 3 4 56 7 cocnrm urn HUS OR REFERENCE DHTIALS HO I 1 1 DATE OF Burnt compart FACTORY FIRST VC exposure Dm OF Diuaosis ict n diagnosis 9 tuts Of EXPOSURE TO 0UGUOSIS -- -- -- ----------------------------1 --l------------------------ 1---------------------------- 1 10 11 12 13 14 | 15 16 1 1 runs or EXPOSURE HR or DEtTH HISTOLOGICAL amnwunm ESTDBRD EXPOSURE | OCCTJPATIOR j OTHER CAREER OTHER COVERTS LEVEL j HIGrt-IOfTS 1 I GEHUKT 1 r 1 Confined t 05 | 1 (most give*! as Case 06) | I I I i I I I l I 1 I 00.00.36 li u 02.04.60 10.12.73 38 I 13 06 {inOSH gives | as Case 09) 07 00.00.32 7 7 16.12.62 00.00.7S 43 00.00.26 8 8 15.04.54 12.11.75 49 13 21 i i i I l I l --------------------------I1--------------------- oe | j00.00.17 1 -- < 19.07.54 11 11 _________________I_____________ i______________ ____________ _____________ 06.04.75 l l 5* ______________ 20 05 16.12.74 lea (IOSH) 12 09.01.7S Yes 21 (KIOSH eaye 12> 13.11.75 Yes 20 25.12.75 Yes _____________ 80 CbeeJe | Reported under sap | non-polymer- "chemistry | lsatlon llaboratorianj workers In |ln the | HIOSH list of |Techno- | 31.3.77 and [logical [Research | | 1.78. I don't thlnfc thin U [ Department" j [(nOSK says j [assistant | factory j j jchemist | a correct clasaif 1cation by HIOSH. The an ee| have been involved [which amj be) jvrcng | In VCH polymerisation | translation)! in pilot plant 1 or in aaln I plant. ___________________________________ 1 PVC - Hanu- [ facture [ Shift Leaderj 1 PVC Hmu- 1 1 | facttire and | all ml j incl auto- f cleaning 12 yra | j (1954-66) | foreman Tech| |Dev 8 ps | (I967-197S) | ______________ 1 ________________ ___________________1 1 ? Pol porker | ? f 1 1 _______________1 ________________ 1__________________ 1 SL 063959 Page 13 GERKMfY LIVER Angiosarcaaa Cases * (Review Date: 1 Jan 1990) Sheet 3 1 -- ------------------ 1 -- 2 3 4 56 ? 8 COUNTRY AM) REFERENCE NO NAME OR INITIALS DATE OF BIRTH amn FACTGRT FIRST VC EXPOSURE DATE Or DIAGNOSIS KK T DIAGNOSIS Germans 1 09 | 1 00.00,34 1 1 1 1 l ! 1 ------------------------- 1-------------------- 1 10 1 (ITTOSH gives | as Case 11)| 00.00,36 2 2 20.02.61 16.06.76 1 2 2 01.01.61 00.01.77 1 1 l 1 l --------------------------1-------------------- 11 | 00.00,29 (ITIOSH gives] as Case 10)j 1 j 1 1 1 1 1 1 -- B fl l 10.10.S5 28.0i.77 l i j 1 ------------------------- 1-------------------- i 1 ---- 12 | 00.00.30 4 4 00.00.61 00,10,77 11 i 11 1 t1 1 ll 1 ll t 11 1 1t 1 1) 1 11 1 i1 1 il 1 _________________1____________ ll j1---------------------------------------- 41 40 47 39 9 TEARS OF EXF060U TO -------------------- 1------------------ -- -- 1 ID | 11 12 13 14 | IS I __________________ ______________ _______________ 1__________________ 11 TEARS AT | DATE Of ansm j kith HISTOLOGICAL carnnmai ESTIMATED | nposote | occwiTioH | OTHER cueer DIAGNOSIS I 1 1 1 LEVEL l HiGHjeHTs ______________ _______________ _____ _____________ 1! 1 16 OTHER cumprrs 1l 15 13 |24.03.78 Tea High peaks |12 frs poly-| 1 [worker loci | 10/78 Coollreed 1 [17\ auto- [ Average 1 [clave | exposure first 1 {cleaning j 9 yra 150 ppm. 1 [Control roanj occ 1000 ppm. 1 H 1' | 1i 11 f ______________ 1 1\ 16 10 |07.03.77 Yes High peeks (lO jra poly-| 1 {worker Lncl | 1 |l7\ auto- | 1 {clave { 1 {cleaning | 11 '1 1 Next 3 yrs av. 75 ppa. Last. fr av 35 ppa Average exposure first 9 its 150 pfs. occ 1000 pps. Last yr av 75 ppm. CHH letter of 1 21.04.78 'l \ ------ 1 ------------------------ 1---------------------------1 21 22 (28.06.77 Tea High 3 yrs auto- ] 1 clave { 1 cleaner | 1 19 frs | 1 filter | 1 1 _________ operator | l---------------------------------------------------[ 16 6 107.10.77 [ Ibs ? PVC Nanu- | 11 facture J 1 Autoclave j 11 worker for | 1 i 7TM 1 1t 1 1 11 1 11 l 11 1 1i 1 1 1 1 ! 11 1 11 i 1i __________________ 1 1 t ________________ 1--------------------------- ___________________ SL 063960 Page 1*1 gerjqot Sheet 4 i-------------r 5 LIVER Anglosaro - (Review Date: 1 Jen 1990) 10 12 13 14 15 16 COWTRT RID REFEREMCE ID HUE Oft HTITULS DATE OP birth conn FACTORY FIRST VC EXPOSURE DUE OF Duaosis AGE IT DIAGNOSIS YEARS OF EXPOSURE 10 DIAOOSXS TEARS OF ora or HISTOLOGICAL, ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 13 00.00,14 00.00.60 08.04.76 63 18 14 19.05.76 Tes F ti Beet letter of j30th June I960 [enclosing data | fra* |Rr H P Frledel of BG Cbe*le (14) 15 (MIOSH gives this as Case 13) 00.00.29 J_____ 1 19.10.53 09.10.78 49 ii J__ L lot an Angiosarcoma | In hie letter | of 21 12 81, j Hr Frledel | |said this ms | |a ,rPlattenepi-| | thelkarline* j |Der [Spelserohre" | (a carcinoma [of the joesofihague) joot attributjable to VCH [not recognised | as i (rial H-- 23.10.78 | I Tes Autoclave cleaner and J___ Drier operator. Later shift |leader I L F V Beet | letter of [30th June I960 jendoelng data |fra* JH P Frledel of |BG Chemle [withdrawing [this caee I I l Angiosarcoma [confirmed [09/79. So*e [detail of this [( also cases [9, 13, 15, 16 jfi 17 given in RRU Report for 1976 SL 063961 Page |F Germany Sheet 5 T" I 1l 1 4 5 -r COUNTRY AND t HUE Oft REFERENCE \ INITIALS DATE OF BIRTH COFAlff FACTOR? NO l +| ----------------- 1 ----------------- 1 16 i 00.00.23 4 4 I i I t I i i [ i I I i i i 1 -r 17 1 ----------------- 1 -- 00.00.37 4 4 (PfIOSH gives as Case IS) LIVES Angloeara i Cases - (Review Date: I Jan 1990) 67 e FIRST VC EXPOSURE DATE OF DIAONSIS AGE AT DIAGNOSIS 10.01.55 07.08.78 (Laibach suspected ASL at Feb 1975 laparotaef) 55 9 TEARS OF EIPOSOItE TO DIAGNOSIS 23 10 TEARS OP EXPOSURE 20 11 12 DAT* OP DEATH HISTOLOGICAL C0NF18UTIC* 07.0a.7B Tea ASL and Hepatocellular Carclnoaa 13 ESTIMATED EXPOSURE LEVEL T--------------------------- H1 15 lb _| 1 | OTHER OTHER OCCUPATION | CAREER cotejrrs | HIGHLIGHTS J _______________________ Hii Autoclave | worker till | t9M. | Leader and ( aaster j j j j lAngioaarcoaa |coofLrwed, (full details jof 11lneas |since March 1973 given In |HRU Had [nap (Rep for 1978. -- -- 01.11.61 14.08.78 41 16 It 28.08.78 Tes | (Different | (details given | | In "VC | (Associated l | Disuse" br | (Lelbecfa and ( (Harrteller J (1981) p71. High Autoclave 1 " Angiosarccae worker |confireed. | Annual report |of the North | Rhine | Westphalia | Medical | Inspectorate jfor 1978 {pages 347-377 (gives full (details. Vlnjl | chloride (diagnosed (02-02-73. | Oesophageal |varices. |fiadlologlcallf | confirmed aero |osteoifsis. 2S.12.79 lfl.l0.S4 Yes ftetastasing ASL Autoclave Worker High (Autoclave |Worker i I i (Dr Besche | letter of |13-04-82 to |[>r W T> F Adaas SL 063962 ll.fi V b. Pa<je K GERMANY LIVES Angloaarcooe Cases { Review Date: L Jan 1990) Sheet 6 1 1 |2 |1 1 COUNTRY AMO | KATE OR REFERENCE | INITIALS NO 70 | t i f 1 DATE OF BIRTH 00.00.IS ---------------1-------------- 1 i-----------------------1---------------------- 1--------------------------- -------------------- J------------------ 1 ------------------ 1 ---------------------- 1----------------------- |----------------------------1----------------------------------------------------- 4 |5| 6 | 7 | 8 | 9 10 1 11 12 13 | 14 | 15 | 16 IIIIII 11 t1 1i 11 1 1 i 1-------------------------------------------------- III 11 i HISTD 11 1 | | FIRST YC | DATE OF | AGE AT | YEARS OF CWWlKYlFACTORY) EXPOSURE j DIAGNOSIS | DIAGNOSIS | EXPOSURE 10 jj j | j DIAGNOSIS IIIII1 t1 11 YEARS Of j DATE OF EXPOSURE | DEATH 1 1 i LOGICAL OOHFimATION ESTDIATED | ) EXPOSURE | OCCUPATION j OTHER CAREER LEVEL | t ! |HIGHLIGHTS [ l | j | 1 1 OTHER COFWNTS 4 | 4 | 14.02.61 | 00.04.80 | 65 | 19 13 |19.1Q.80 Yes High | Autoclave | |Dr Besche letter of 1 III 1 1 1 Haeaanglo |Worker | |13-04-82 to 1 III 11 1 Endotheli<ma j | |Dr W G F Aden 1 t 1 1 21 | 1 III 11 III 11 11111 1 1 11 11 |00.00.13 1 4 | 4 | 01.01.62 00.09.79 | 66 | 1 1 11 pronounced | | 18 1 of liver iftth | | | 1 Hetastaeei* 1 1 1 1 11 Yes 13 |19.06.80 11____________________l | High {Autoclave | | Dr Besche letter of 1 Hacnacgloj |Worker and | 113-08-62 to [1 1 11 clinical | j 1 Endathelicw |worked In | Jor HOF Mama 11 1 11 liwr | | 1 of liver with (drying shop | | 11 1 1 _______ 11L 1 1 1 11 il 1 Hetestases f | f ii lt1___________________________________________ ___ J 22 00.00.21 4 4 IS.10.61 2a.oa.eo 59 19 n 06.12.81 Yu HI* Autoclave Chargehand, Dr Besche letter of Netastaair Worker subsequently 13-04-82 to ASL Foreran Dr W G F Adras 23 00.00.27 8 6 1955 26.03.79 52 24 21 29.09.81 Yea High Chenistry (>300 pf) Worker Prison hepatocellar carcinora; proliferation of the sinus iodal cells with sinusoidal ectasia. Friedel letter 23.12.86. i 24 | ^i |(J0.00.28 | B i |8 i | 1969 ii | 11.10.82 | 54 i | 13 ii f 12 |28.05.83 Yes 1 | High | ------------------------ 1--------------------------- 1---------------------------------------------------- Autoclave j {Prof Eder (Munich) 1 1 111 1 1 1 II |<>300 ppv) Cleaner E | letter 22.08.S3. 1 1 111 1 1 1 II 1 | |Friedei letter 19.04.85. 11 25 | 1 11 (00.00.23 | 8 11 |8 11 i 1060 11 | 28.OT.8l 11 ) 58 1T | 21 IIII 1 13 (14.01.83 1 i Yea | High Polyclave 1 f | 1 1 {Prof Selnalr (Munich) 11 111 1 11 II 1 Worker and [ {letter 22.08.83. 11 111 1 11 II 1 Autoclave | |Frledal letter 19.04.85 11 111 1 11 II 1 Cleaner | J --------------------------j-------------------1-------------------- 1---------------1-------------- j-------------------- |---------------------- 1--------------------- 1------------------------ 1----------------------)----------------- --------------- 1------------------- ------------------------ 1--------------------------- 1----------------------------------------------------- (26) 1 ! Ii| | |j j j Delated aa advice of Dr Tenkhof f Decker 1989: | 11 111 1 11 1 [Alcoholic Cirrhosis, not YCH asiRelated. | { -------------------------- 1----------------- 1------------------ )------------- j------------- 1-------------------1-------------------- 1--------------------1---------------------- 1--------------------j---------------- --------------- 1------------------- ------------------------ )--------------------------- 1---------------------------------------------------- 27 | |00.00.2e | 4 | 4 | 1955 | 18.01.83 | 55 | 28 I 18 |02.03.64 Yea | High Autoclave | {Lelbach. 11 111 1 11 II 1 Cleaner tili| (Friedel letter 11 111 1 11 II --------------------------1-------------------- 111111111 1 1972 | 119.04.8S __________ 1____________ ________________ 1__________________ 1__________________________________ SL 063963 J- Page GERMAHV LIVER Anglosarooaa Cases ( Review Date: 1 Jan 1990) Sheet 7 -------------------------- 1------------------- 1------------------ 1 1 |2 | 31 -------------------------- 1---------------------i-------------------1 1 4 1 .| 1| 1 5| i| 6 t 1111 COUNTRY MID 1 NATS OR | DATE OF | | I FIRST YC REFEREHCE | INITIALS | BIRTH jcOtffAirrj FACTORY | EXPOSURE *0 1 1 III -------- 2fl 21.Ll.23 7 7 01.10.60 ii 7|8 | 11 l 1 II 9 Dm OF [ ME AT 1 YEARS OF DIAGNOSIS j DIAGNOSIS [ EXPOSURE TO | j DIAGNOSIS II -- 11.0B.85 61 ZS -------------------- 1------------------ ------------------ 1---------------------- 1------------------------ 1---------------------------- 1---------------------------------------------------- 10 1 It ______ ______ l 12 | 13 | 14 | 15 | 16 1-----------------------------------------1------------------------1---------------------------- 1--------------------------------------------------1 1 HISTO | lt TEARS OF | DATE OF LOGICAL j ESTIMATED i OTHER | EXPOSORE j DEATH C0HFTRH-[ EXPOSURE OCCUPATION j CAREER j OTHERCOMERS 1 AT10K j LEVEL | HIGHLIGHTS j 1j 25 25.08.85 11 Tea High Process worker 11---------------------------------------------------------------------------11 | {Annual VCH screening j j24.04.85: no co^lalnt, 1974-84 | | |oo abnonaallty detected. jl970 tuo-thlrda 01,10.60 - 31.03.84 PVC | | j Igastrectowy for ulcers. |l971 Coronary thrc^xwls {1983 Tenoral product loo, | | lamentation agitator \ |1984 Pulaonary eabollai area | {and pleuropoewnola. { |Landers letters 1S.09.B5 , j |and 04.02.87. 1J--------------------------------------------------------------------------------------------------------1 29 00.00.22 2 2 1962 15,02.83 61 21 19 15.02.84 Tea High Chenistry j iHaenanglosarfenn. worker | |Frledel letter 23.12.86. 11---------------------------------------------------------------------------ll 30 00.00.17 4 4 1951 07.01.BO 62 29 25 25.05.83 Tea High PolTWorkar 1 |Hac--pglosrlp--. Shift letter j (Friedel letter 23.12.86. 1---------------------------------------------------- 1----------------------------------------------------- M 00.00.23 0 0 1953 30.06.85 61 32 20 31.01.86 Yes High Autoclave cleaner | KaeaonglasarkoM. |Frledel letters 23.12.86, [15.11.89 6 Fettle! 16.2.B9. ---------------------------- 1---------------------------------------------------- ------ 32 00.00.30 6 * ">55 00.04.85 55 30 21 15.07.86 Tea High Polyvorker Kaenanglosarkona. Also Autoclave Developed Cholanglosarcana. cleaner Friedel letters 23.12.86, 15.11 .89 and Fendel 16.2.89 a33 00.00.17 B 1953 19.08.83 67 30 21 25.03.85 Tea High Autoclave Cleaner, Chenistry Worker 1634 00.00.34 4 4 1956 13.05.85 51 29 17.09.85 Tes High Shift Leader Letter fra Dr Friedel 15.11.89 Jitter fra Dr Friedel 15.11.89 39 00.00.24 4 4 1968 16.2.73 49 5 4 16.10.84 Tea High Autoclave Cleaner 1975 disease of liver parenchywa; at last 8GV Letter fra Dr Friedel 15.11.89 SL 063964 GERJUNY Sheet 8 LIVER Angiosarcoma Cases ( Review Date: 1 Jan 1990) li I 10 I 11 |12 13 -- -------------------- 1-------------------1-------------- 1-------------- 1-------------------- 1---------------------- 1--------------------- -------------------------- 1--------------------- 1------------------ ------------------ 1----------------------- 1-------------------------1--------------------------1----------------------------------------------------- 1 111 1 1 l1 HISTO | t 1 1 couimrv AND REFERENCE NO NAME OR |DATEOf | j INITIALS jBIRTHj COMPART j FACTORY | 1 11 [ FIRST VC | DATE OF j AGE AT UPOSORE jDIAGNOSIS jDIAGNOSIS 11 1 TEARS OF EIPOSURE TO DIAGNOSIS | TEARS OF | DATE OF j EXPOSURE | DEATH j| LOGICAL |ESTIMATED [ CORFDM-1 EXPOSURE| OCCUPATION j AnON j LEVEL j | OTHER | CAREER | | HIGHLIGHTS j OTHER COTTENTS 36 00.00,18 4 A 1953 19.01.76 57 23 23 14.0(2.66 Yes High Autoclave Worker letter fra Dr Priede 1 15.11.89 and information from Dr Tetikhoff Dec 69 37 00.00.25 4 A 1%9 09.08.85 59 16 6 05.09.86 Yes Laboratory Letter fra Dr Priedel Assistant 15.11.89 38 00.00.22 A 4 1954 16.05.66 66 34 19 16.09.86 Yes High Shift leader letter from Dr Priedel at the 15.11.89 autoclaves; later on at the timfcler 39 00.00.42 A 4 1966 00.10.86 44 18 5 03.U.86 Yes High Autoclave Cleaner Pension fra 1974-84 SO* later oo 100%. Letter from Dr Priedel 15.11.89 and Information from Dr Tenkhoff Dec 89 SL 063965 ITALY LIVER Jtogioaarcoaa Cmi * (Review Date: i Jan 1990) Sheet 1 i -- ------------------ 1---------------------- 1 -------------------- 1I---------------------- 1 -- 2 3 4 56 7 0 9 C001FIRT AW) REFERENCE NO NRIB Oft INITIALS DATE OF BIRIN oemn MCTOBT FIRST VC oposm nn or ouansis AGE AT DIAGNOSIS TEUS or moon to ononis 10 nus or ---- 11 12 nn or KITH HISTOLOGICAL conmnoN 13 ESTDUTED eiposom LEVEL ---------------------- J-----------------------------1 14 | 15 l ----------------------1---------------------------- 1 | OTHER OCCUPATION j CAREER j HIGHLIGHTS 11 16 OTHER ivjfmns 01 LG 15.06.34 PMSIC Hr* 00.00.6S 19.04.71 36 06 03 16.04.71 TTea PVC Bag | Primary toocir (On HIOSH Venice extruder | may bsva been staple - 1 pericardia. sectary 1 Not homo- list) I ganaoum with 1 l-------------------- 1 i 02 |SE 13.11.29 Montedison Porto 00.00.57 13.12.72 43 15 06 27.12.72 T | 1 ----------------------1 Polymarker | ** | * 1 1___________ Hargbara 11 1 _____ __________ 1______ ________1 | 03 VG 14.03.20 Solvay Ferrara 00.01.53 10.07.75 55 22 21 10.07.75 Tea Hi* Autocleeaer 1972-5 did , B yra (1953- a variety of El) Autoclavei lob. operator including ** 12 yra (1961 * PVC pecking. 72) 04 FB 20.07.37 | MIC Ravenna 00.04.59 00.01.81 43 21 21 30.03.61 Tes 12 yra - l yr - Never cleaned 1 Very High Homer autoclaves. 1 operator See paper by ** 1 5 fra - CHUFPHO et Noo-amnfcar. 1 Nadia 20 jra - al Ned Lavoro Cooaaed 1 Autoclave Vol 6 (1982) little 1 * 4 fra - operator & pp 555-563 alcohol. No 1 Loa other duties AOL. 1 in auapens- 1 ion polymer 1 isation. 1 1 Area Foreman 1 in earn* Dept 1 since 1975. ii r 3i i i _________________ _____________ 1 ______________ 1 _________________ OS G Domain 119.03.37 | PUBIC Hire | 00.00.67 | 07.03.S3 | 46 16 | 0 06.04.03 Tea [Hedlw-7 Bag extruder) | SPagllalinge 11 Venice j j 1 1 |H1* 1967-1975 j jtelex of 11 t[ 11 1 11 1 1 t 1 Caaeerclal j 1 Dept 1976- j [2 lug 1903 j t J11 1 ii i ii-------------------------------------------------------- 1-------------------- l 1 l 1963 | | ________________ 1_____________ ______________ 1_________________1------------------------------ * See Hal tool Ned di Lavoro 65 p445, 1974. Further details in letter fro* Dr Hontesaoo of URC cm April 1st 1962. Also see Msltoni and Rondlnella in Acta Oncologica Vol 1 1900 pages 35 - 49. SL 063966 Page 20 ITALT Sheet 2 LIVE* Ingloearoona ban - {Daria* Date: 1 Jan 1990) ---------------- 1 l 23 COWTRT IMD REFERENCE NO UK OR mruLs DATE OF BIRTH 06 Gl 21.06.36 --------------------------[---------------l 07 | AP 09.02.25 1 1 t 1 1 1 1 1 ------------ 1 9 ocmput ftontedlsoo Noplefan 56 FIRST VC FACTOR! aposm Porto 01.10.60 Narghera, Venice Tend 1958 7 89 10 11 TEARS OF DATE OF Ul IT EXF060RS TEARS OF DATE Or DIAGROSIS DIAGNOSIS TO EDOSORE ecm DIAGNOSIS 06.12.85 49 25 25 13.02.86 21.01.86 60 28 22, 05.H.86 12 13 HISTOLOGICAL ocnrnmnoR EEFOSORE LEVEL Tea High 1960-71 Nadlw 1971-74 [ 1975-85 Tea 1958-74 High 1974-80 Radian i 14 15 | 1 I 1 16 OTHER | OCCUPATION career [ HIGHLIGHTS | 1 1 l arm ujkiu PVC | Letters fra Dr Chiouinl, Venice, eanufadore | 22.09.87 and 11.01.88 11 rears as t Autoclave l i 1960-71. I 14 rear* in Control Rook 1971-85 i I I ! 1 1 l Maintained VC Hachiner (not operating ] Lnforestloo fra La adlcina del j laroro, Italj, Vol 79 lo.l j Jan-Feb 88, and Dr Beoetta, j EnlChee. or cleaning autoclaves) VC levels reduced fra 1973/74 I ! 1 I 1 11---------------------------------------------------------------------------------------------- 1 1 1 1 l 1 1 1 1 1 li 1i l 1 i _______ | I 1 1 1 1 1 1 1 1 1 1 1 i i SL 063967 Page 21 JftPM LIVER ftngio Cum - (Revlon Dote 1 Jon 1990) -- i 1 2 3 4 56 7 s 9 COUNTRY UD REFERENCE HO KUC OS nmms MTS or BORN COMET FACTORY FIRST YC EXPOSURE DATE OF diagnosis AGE AT DIAGNOSIS TEUS or EEPQSOU TO Dixansis 01 Tomoji 01.08.Z2 Itttnl Kagofa 00.04.S3 Z4.10.75 Rorl Toatsu 53 22 ------------------ 1----------------- -------------------- 1 -- 1 02 SC |02.00.39 Xsnegafochi Osaka 00.11.58 10.00.76 1 Chemical tl 1I 1l . ------------------------1------------------ 1-----------------1-------------------f 11 03 |VS [01.09.30 |Mitsui Kagora 00.07.6S 26.06.05 | | |Toatsu 1 11 1 11 1 11 1 1___________ 1____________ 37 -------------------- 1 1 54 | l 1 1 1! 17 20 10 11 TEUS or DATE OF HPOSOtE DUTH 13 24.10.75 13 10.08.76 5 14.09.85 ________12 13 14 | 15 16 _________________ 1 1 HISTOLOGICAL coNFimnoi ESTIMATED EXPOSURE LEVEL | OCCUPATION j OTHER CAREER j HIGHLIGHTS ________________________________ 1 1 1 OTfSR uumna Tea PVC Isaac 13 yra auto-| Japan Tlmea saja not clave | 25.10.75 know). Japan Tlmea cleaner 196* - | j assigned to [ Japanese PVC Assoc letters of 31.03.7S Indicated different | 30.11.87 oo 2S.10.75 work sJ ooe ( exposures often at had 111 health 1 j 3000 ppm up 1 to 197* 1 I 1 1 1 I Yea Not known |ln polymer- | t lestlan work] j Including j Japuese PVC Association letters of | autoclave l 31.03.78 | cleaning J 30.11.07 11---------------------------------------------- 1 ii i Yea | High |5 jaara f Letter from j (Autoclave | | |cleaDer | Japanese PVC II I Association li i 30.11.87 ii------------------------------------------------ 1-1------------------------- Si M96S Page 22 MORUAV LIVES Anglosarcaaa Cues - (Review Date: 1 Jan 1990) 1 1 1 |2 I l 1 COWntT AMD | H1IC 06 REFERENCE j INITIALS NO j 1 I i 1 1 01 |jui 1 3 4 DATE OF BIRTH COUNT 23.12.15 Norsk Hydro 5 FACTORY Heroya 6 FUST VC UPUSOU 00.03.50 ---------------------- 1---------------------I 7|8 1 1 1 ran or | Kt m oiionsis j Duansis 21.12.71 1 1 1 1 1 1 | 56 9 TEARS Of EXPOSURE 10 DIAGNOSIS 22 -------------------- 1------------------ ---------------------------- 1----------------------- 1----------------------l 11 10 1 11 1 1 1 12 | 13 | 14 11 11 11 TUBS or t Ntt Of HISTOLOGICAL | ESTIMATED | FQStn j DEHH CONFIMAnOM | EXPOSURE j OCCUPATION 1 j LEVEL j 1 tt 1 it 1 tl 1 l1 1 21 |.01.72 ll ?e* | High |Fonm 6 Autoclave s^ervisor 15 OTHER nuntn HIGHLIGHTS 16 OTHER OOtBNTS Confined by Or ThiiaEtbmbo of Ml. At Am Htg or 9 Jibs 1976 stated that AH had been a rttr of a ftart-i*> teas, VCVI A PVC were aada la aaae building. The VCH ms aade froa acetfleoe t 063969 SL 1 Page 23 SPAIN I LIVER Angiosarccea Cans * {Review Date: 1 Jan 1990) -- -- i -- ---------------------- 1 2 j3 4 5 6 7 e 9 -- ---------------------------- 1 ------------------------ 1---------------------------- i 10 u 12 13 14 | 15 ________________1__________________ 16 conmtT uo REFERENCE NO ME OR DHTULS DATE or BIRTH OOPUT HCTORT FIRST VC EXPOSURE otn or DIAGNOSIS Id IT DIAGNOSIS TEARS Or Eiposms TO DIAGNOSIS nuts or EIFOSIIU DIR OF DEATH HISTOLOGICAL ccmmorsm ESTIMATED EXPOSURE LEVEL occoptnoR OTHER CAREER HIGHLIGHTS OTHER Conors 01 NOS 26.03.40 Hltpnlc `orrelavegi . 01.02.64 10.11.09 49 25 13 09.11.09 Tea HI* Autoclave Fn> 1.1.78 Cause of death: 12 rears Operator production of nltlpie 12 fears. hydrogen cerebral peroxide heeMorrfaeges. Nediiai latex No Metastasis. 1 fear 1 year Letter free Dr Lagast, Solvay, 04.01.90. 06397Q Page 2*1 SWEDES LIVER Angiosarcoaa Cam* - (Review Date: 1 Jm 1990) 1 cowrm ud REFERENCE m 2 RAK OS DOTIALS ---------------------- 1 -- 3 4 56 MiE or Birm COfflUT FACTORY FIRST K EXPOSURE i HR OF DUGH0SIS * 8 WE AT DIAGNOSIS -- 9 to 11 nuts of EXPOSURE TO DUGUDSIS TEARS OF EXPOSURE otn or nun 12 HISTOLOGICAL CCWTRfttTIOR ---------------------- 1------------------------ ---------------------------- 1------------------------------ 13 | 16 15 ( 16 11------------------------ -- -- ESTDBRD | OTHER OTHER EXPOSURE j OCCUPATION CAREER COVERTS LEVEE | II HIGHLIGHTS 1 01 HD 23.06,27 (award Sundevell 16.08.51 20.10.70 43 19 18 30.10.70 Yea jPolyiparter ------------------------1---------------------------- 1 02 BL 27.11.11 ti--nnrd Sandcvall 00.01.65 00.00.72* 61 27 27 16.08.72 Tea High YCH | It Sjoalln1* production | letter of t 2B (fan* 1976 i confine BL i i norter vho wee i beavili i exposed, i probably even i ore so than i a DOTBOl 03 HE 04 11 10.06.10 Eeaeoord Sundsvall 00.05.47 18.03.76 16.11.H Fi--inrd Sundmll 00.00.46 12.05.77 65 62 , 29 31 21 19.03.76 31 12.05.77 Tee Tee High High Polrvorftar 1946-1956 poljwr- i i i1 J 1[ | | reactor cleaner In first 12 yrs of Isstlon ) eaployeot had worter (12 ] Tre) 1956-j been beevilf exposed. Ln 1977 foresanf 1974, liver (19 Trs) | aboornalltf i aod necrosis i diagnosed. I Data confined I in Dr D Bjren i letter 16.8.77 i 05 ( 1 11 11 12.03.19 | Ewnord |Stmdmll| 11.05.66 22.11.80 J 61 | 16 ___________________ 1 16 |Z2.11.80 Tea i | High - 1964-1970 1 i 1 | to CEFIC I (Letter of 1 1 11 11 1 | 6 lri centrifuge | j 2nd Rov 1901 1 1 11 11 1 | Loo - operator f (fra 1 1 11 1I 1 | 10 Tears 1970-1980 j |Dr David Byree i 1 11 i 1 11 ____________ 1______________ 1____________ 1-------------------- 11 I1 11 1 1 drier | 1 -1 1 operator | ---------------------------- 1_______________ J1 | j * In his letter of 1st April 1962, Dr Nontesano of LARC safe Sweden's Rational Board of OS Health gives 20-02*70 as date of diagnosis for Case 01 and 15-05-72 for Case 02. SL 063971 UK Sheet 1 l 23 COUNTRY AND REFERENCE NO HUE OR INITIALS DATE OF birth IJT LIVER Anglasarocan Cues - {Review Date: 1 Jw 1990) 4 oavuir 1---------------------- l 56 7 _____________ 6 | rust vc ncTORT EHMSDU 1 ------------------ --------------------1 1 one or DIAGNOSIS KE IT ouaosis 1 9 TEARS OF exposure id ouonsis 10 TERRS OF EXPOSURE 1---------------------------- -- ii 12 13 -- J 14 I is HTE or DUTH KISTOEOG1CU. coRmnnoi ESTDIITED EXPOSORE LEVEL 1---------------------------OTHER OCCUPATION CAREER HIGHLIGHTS 16 OTHER covens 01 HJ 20.04.01 ICI HUlbouw 04.04.44 03.12.72 71 28 i 1 (Fo* 6 1 1 Collier t f 1 paper says 1 I 1 23.12.72) 1 II 1 l -------------------- -1-----------------l l 1 11 '1 1 (02) I 1 l1 --------------------1------------------ ______________ | i 22 03.12.72 Tea 500 p[ 1944-7 VCR (row 6 | 1947-8 Drier Collier | 1948-61 W 1 Autoclave r* 1 operator 23.12.72)1 1961-66 1 ti---------------------------- Drier I I Lee and Harry Lancet 29-06-74 pages 1316-8 Dubious fabrication 03 BJW 02.06.37 BP i 1 -------------------- 1------------------ Barry 00.02.66 i I i 00.12.74 i 37 ______________ _______________ J 09 3.5 24.12.74 1 1 1 Yes _ High Autoclave cleaner Exposure Halted to 2.66 - 9.69 CM JSR 23.06.20 I 1 1 1 1 1 1 l 1 1 1 1 1 1 1 ICI i1 1 -------------------- 1____________ HiXlhouse 26.04.54 1 00.06.79 1 59 25 11 11 f1 11 11 1i 11 11 11 11 11 11 t1 1 11 11 11 ( !1 1 ____________I_____________ ______________ 1______________ _________________ i 18 12.10.79 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 iL Tea Nedluhigh 1951-5 Ragging Plant 1955-6 Drier Plant 1956-8 Autoclave worker 1958-61 Chargehand Drier Plant 1961-72 Foreman |C 2/1 Plant 1 Pre-war fish mcker 1939-45 oray vehicle Maintenance 1945-54 nsb packer 1 | i SL 063972 Page 1 COCJKTRV MB) REFERENCE NO UK - Sheet 2 1 BMC OR date or DTITULS BIRTH 30.03.14 BP t931 26.04.20 BP wm 06.05.24 BP FIRST VC EXPOSURE LJVER Anglogarcc-- Cases - (Review Date: 1 Jan 1990) 8 DATE Of" AGE lit TtARS OP TEARS OP IMTE OP DIAGNOSIS DIAGNOSIS EXPOSURE TO EXPOSURE DEATH DIAGNOSIS 12 HISTOLOGICAL CONFIRMATION 13 T M ESTIMATED f exposure | ocaipAnar LEVEL I 15 OTHER CAREER HIGHLIGHTS OTHER COtiffiTS Barr? 06.01.51 00.10.79 65 19.11.79 Yes Barry 1962 09.01.60 46/9 IB 12 09.01.80 1195)-52 ] iPotpclMner j j1952-55 j I Late* j1955-60 | | |PoIpfloor | 11960-69 j \Polf [Chargehand j1964-70 / | j JCharging (operator [1970-72 |Drier | { f | | operator + 17 fTB | [Polf Floor | Operator |5 jrs {Greaser on |Polf Floor jFurther [inforaatloo |1989 Fran |Dr P H Skltb {and Dr D H J {will lass i j i i i i i i i Further inforsetlon 1989 fn Dr PA Ssith and Dr 0 A J Ullllass Barry 60 17 6.2 13.06.80 Yes (Polfcleaner 11963-5 |Recovery 1965-1971 Further InfcrntatIon 1989 fros Dr PH Utb A Dr D H J William Barry 27.11.61 -1______ I_______ L SL 063973 24 25.12.61 _I___________ L_ 1950-1958 500 pc. 1966-1974 200 pcs 1950-51 11938-1948 1 Further Autoclave [Motor Mechanic {inforsetlon operator |1948-1950 |19S9 fra [1951-1957 (Operator on |Dr P H !*Uh jchargesac |lcetyleoe |nd Dr D H J (autoclave [Production | Willi {building [Plant 1 (1957-1974 jshift | supervisor (autoclave t i i i 1 1 1 1 building * Never [cleaned |autoclaves i i i i 1 1 1 1 |but i {supervisor s| 1 (job entailed) 1 [entering | autoclaves to inspect | the* i i i i 1 1 1 ! Page UK Sheet 3 l i 2 11 COUNTRY AND | KANE Oft j DATE OF REFERENCE j INITIALS | BIRTH NO j--------------1 09 |EIGP |07.05.25 LIVER Angiosarcaaa Case* - (Revieu Date: 1 Jan 1990) l-------------------- 1 4 15 6 7 OOHPJWT | FACTORY FIRST VC EXPOSURE J---------- ! BP [Barry 15.02.50 i DATE OF DIAGNOSIS 02.03.83 6 AGE AT DIAGNOSIS 58 9 YEARS OF EXPOSURE TO DIAGNOSIS -- I------------------ 1 10 11 nuts of EXPOSURE DATE OF DEATH 1 T-------------------------- 1------------------------------- 12 n I H | 15 | 16 il ---------------------- 1i---------------------------|1------------------------------ HISTOLOGICAL esthuted 1 OTHEB 1 OTHE* CONFIRMATION EXPOSURE | OCCUPATION | CUEEK j COmEKTS LEVEL j HIGHLIGHTS | H--------------------------- 1------------------------------- 13 29 24.02.83 Yes Kedlvm |poljwrker |2 years oo ( [Acrylonitrile [ JResIn Plant, j [Also prior to | [1950. 4 years| (MF 1 laolotenaoce. | [3 years sotor [ (car paintsbop. | |2 years In J [Graving Dock, f \------------------------ 1 1------------------------------ IQ |gjt |04.04.47 BP (Barry 27.04.66 01 05 84 37 18 4.2 16.05.84 Yes High - 11 | Polycleaner |Heavy goods (Information i oaths (500)1966-67. [vehicle driver[given In pj). Lew [Spray-drier [until final |letter 18 Booths |bagger 1%7-f Ulnea. 116.06.54 frao (50 pfa). Itodlw - |68. |Bloa-dcwQ | | [Dr D 6 J juilliaM 21 Booths [stripper 1 I (200 pf>) [operator j1968-70. 1 1 1 1 CLP 08-05.28 BP Barry 19.12.65 02.06.85 57 l --------(- 16 02.06.85 |1 Yes [High [polycleaner |Letter of 1 (l%5 -69 [1965-68. 1 [Med 69-29 | Service |CH.06.B5 jor Paul Saith 1 |Low 79-82 [operator [and letter of 1 I (68-69. (04.06.85 1 I |PolT (Dr D ft D Evans 1 I |Operator | Oesophageal 1 I (69-79. [hacaurihage 1 I [Leading Hand [due to f i [79-82. [oesophageal iI (varices due to Il | Angi osarcobs 24,01.37 ICI Hillbotise 16.09.57 03.06.65 48 28 06.12.65 Yea 1 i1 [of liver i J___ _ -- ----------------------------1----------------------------- i i------------------------ 1 [Low 1957-59jSpere an. [letter [High 59-74 (tagging j26.06.s5 1 |Low 74-85 |floar |Dr F I L 1 I [1957-59. 1 1 I (Autoclave 1 1 I [Operator I 1 (1959-85 1 t i J________________ 1__________________ 1___________________ SL 063974 Page 1 "1 UK - Sheet 4 LIVES Angiosarcoma Cases - (Review Date: ] January 1990) ------------------------- 1--------------- 1---------------- 1--------------------1-------------------- I |2 | 1| 4i5 ------------------------- 1--------------- 1---------------- 1-------------------- 1------------------11\ 111 6 i 1 89 TEARS OF 10 -- ------------------1------------------------------ n 12 13 | 14 IS 1 | 16 ----------------------------- j---------------------------------------------------------- --- 1------------------------------ HISTO 1 l COUHTRY MID {NAME OK | DATE 0F| REFERENCE jllimALsj BOTH [ COMPANY FACTORY NO III ------------------------- ----------------- ----------------- 1-------------------- 11 i 13 | flj |02.03.4fl|BP Barry FIRST VC EXPOSURE 1968 DATE OP AGE AT EXPOSURE TEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DUE or DEATH Jan 86 37 18 3 02.06.86 LOGICAL ESTIMATED CQRFIMf- EXPOSURE AT30N LEVEL OCCUPATION Tea High Pojycleaoer OTHER CAKES HIGHLIGHTS | | j OTHERCCWEHTS ----------------------------- ( Moved to (pemnliwd well, working Ii i1 11 11 11 11 I 1 1 1 1 1 Low Httfi 1968-69 Central Depot 1969-70 Polyfloor 19T0-I971 Acrylonitrile Plant until left BP 1983. J actively, until Jan 1986 [ j Manager of IC sj SS Ltd at j Cardiff Airportj 11 1 ------------------------- ----------------- ----------------- | 14 (gS JIS.06.4 |bP Barry |q7.07.66 27.08.87 45 1983-86 11 |oi.l2.B8 21 Tea 10 months Polycleaner ) j Letters from Dr OHD Evans, 11 1 i 1 High 1966-67 (Pathologist, Peoarth, Wales 11 1 i 1 10 yeara Polyfloor [and Dr OHJ Williams, BPr Barry 11 1 i 1 oonatact worker at times i 11 1 I 1 fediw betweeo i 11 1 i 1 but GO 1968-1982 i 11 1 i 1 Inter i 11 1 i 1 mittent i 11 1 ------------------------- 111 ii IS BCP |23.08.2 |BP I ____________ i____________ ii Bany |t956 (1986 i | 66 .. . 32 16 1 1I | 01.05.88 Yea jot* i ------------------1 ------------------------------------------------------------- l1--------------------------------------------------------------- 9 yeara Roly cleaner 6 ) llnforaation fras 11 11 11 11 I 1 1 High Operator ) jDr 0 K J Wllllans, BP, an) 1 5 years Blow Recoxery)EXf>OS"re Dr Paul Saith, Pathologist 1988. I1 I1 11 11 1 1 1 flediim Operator fI 1 Utility 2 years )ln,eTMment | 11 11 11 1 111 1 __________ L ____ Low Operator L_ _ ) | i 16 RT 25.05.2 ICI HI 1]bouse 1963 1988 66 25 12 12.11.88 Yes 1 year ) Packer Lem ) 9 years) HI* l 2 years) Low ) Autoclave Operator 17 RN 14.01.31 1CI HLllhouse 08.04.63 1989 58 26 25 17.09.89 Tea 1963-63 Packer Low 2 months 1963-74 > High ) Autoclave (11 yeara ) Operator 1974-88 I ) 25 years Low j > (U IMTS| > Hepatic fibrosis 1974 Oesophageal varices Porta-caval shiat 1975 Information from Dr 8 Bennett, ICI, and Dr F 1 Lee, Blackpool Victoria Hospital 1988. Information from Dr B Bennett ICI, and Dr F I Lee, Blackpool Victoria Hospital, 1989. SL 063975 Page ^ UK sfstea of dates USA LIVER Angiosarccaa Cases - (Review Date: 1 Jan 1990) day - month - year Sheet 1 1------------------- i 12 ^ j1 COUNTRY AND | REFERENCE j NAW OR INITIALS | DATE OF ( BIRTH 1-----------------4 |5 J 1 1 COWANY | FACTORY --------------- -- 67 8 FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO ------------------ r "T-------------------- n------------------------ -- 10 I 12 1 13 1 H 15 _____________ 1 1 l_ * _J 1 J1 ----------------------------1 YEARS OF | DATE OF ( HISTOCjOGICAL 1 ESTIMATED 1 OTHER EXPOSURE DEATH | CONFIRMATION j EXPOSURE | OCCUPATION CMtEER 16 OTHER OCWDfTS NO 1 11 1 1I 1 11 1 DIAGNOSIS 1 | LEVEL 1 HIGHLIGHTS 1I 1t nT 1---------------------------- 1 1 1 | iHistorj given Rolling Stone l1 11 01 (Earl jl7.10.23 BFG |Louis- 09.12.46 03.03.73 49 24 21 03.03.73 | Yes 1 | | In Annals NT Art [Pot Cleaner as SCIENCES Ref 1 NY Acad |Parks l | vllle l I 1 |(Block Jean Yol 329 (1979) of Sc Stc> i 1 j 1979) p 53 page 190 in 1974 11 I 1| |Paper by Also Block l1 ) 1| |B R Cottine of Jw 1.7.74 1 11 1------------------- 1 02 1 |J9.06.33 BFG l 1 1 1------------------ |Louisj ville 15.11.S5 00.OS.70 37 i1 i1 11 14 13 27.09.71 | Yes 1 (HIOSH | 1 1 J I | Pot Cleaner j(Cf Block) OSH* p 53 Her 1 Also Block lI safe | !f JANA 1.7.74 1 1J------------------- 03 |Edward |2S.05.15 BFG | Dinwiddle \ i1------------------ | Louisj vllle 28.11.45 19.12.73 58 28.09.71)| J1 ! i1 28 28 19.12.73 | Yes 1 ii 1 11 fPot Cleaner j(Cf Block) Louisville Courier P 53 Ref L Also Block Il I iI Journa i 11 11 1 1 i1------------------ 1t 04 I |15.01.24 BFG |Louis- 06.07.52 19.08.67 43 IS 15 07.01.68 | Yes 1 * 02-09-90 j j Pot Cleaner Ref l i | vllle 1 1 |(Cf Block) Also Block it J1 11 J1 I OS I 125.01.12 BFG | Louis- 19.06.44 09.04.64 52 20 20 09.04.64 | Yes 1 ! | vllle 11 |Pot Cleaner j(Cf Block) Ref ] |Also Block 1 i 1------------------ 1 iJ------------------ j 11 06 |Raf (23.11.28 BFG |Louis- 17.01.62 00.02.74 45 12 12 24.07.75 | Yes 1 1 __________________ j___________________ 1I (US Air Force (Ref l + |AustIn | vllle i it Louisville |Jones? l i i |Pot Cleaner ;T3jkg 23.7.75 iI i i her Block) Retired April il i i1 1974 i1 t 11 i------------------- _|1----------------- 1 _j J1 1 11 07 | Charles (03.OS.22 UCC |S Cbarle- 27.08.44 00.00.68 45 24 17 23.03.68 | Yes 1 1 |T Swart | stem I i1 11 1 1 i------------------ L. i _l1 1 t1 08 1 (06.0S.20 Goodyear |Niagara 07.10.46 00.OB.61 41 15 IS 29.OS.61 ) Yes i 1 lAlso Block |___________________ l Ref 1 __________________ | ___________________ Ref 1 1i !i 1 i1 i i1 1 _i____________ J____________ i jt I 1i L. _j 1 . SL 063976 Page J USA - Sheet 2 T----------------- 1-----------------1I 11 J 1 COUNTRY AND | 2 13 | 1 NAME OR j DATE OF REFERENCE | INITIALS | BIRTH NO 1 1 11 Tt 09 (Rayaond IO0.1L.31 [Get tie- I 4 1^ 1 1 COUPANY j FACTORY 6 FIRST VC EXPOSURE 1^ AFG (Louis- 28.OS.45 j vllle (finger? I ii ii ii II Il 1l \t 11 1 1 10 1 |l6.08.13 Goodyear (Niagara 12.06.51 11 1t n1 |27.05.09 Goodyear (Niagara 14.10.46 J1 \1 12 |Francis A (i7.ii.ia Firestone (PottstowD 13.07.49 | Bachaan 1 | Pa i1 I1 i1 !1 11 11 11 J1 n (Richard |01.12.21 UCC |Edward i 1 I |s CharIe* ( stoo 11.12.42 (Clendenio | J____ i i 1________ J n 1 (H) i i f 1 i1 i1 i1 i( i1 (!>) 1 t 1 i 1 11 1 1 j i1 11 _l 1 ! LIVES Anglosarcoaa Cases - (Review Date: 1 Jan 1990) 7 DATE OF DIAGNOSIS 6 AGE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 10 1 11 j T YEARS OF | DATE OF EXPOSURE | DEATH 01.03.74 43 29 24 |ll.03.75 00.05.60 55 17 17 110.05.68 00.03.70 61 23 23 116.03.70 02.05.69 50 20 19 |02.05.69 00.05.74 52 -- 11 32 26 |07.04.74 ______________ 1 UK systen of dates DAY - NOtTIM - YEAR li i i 12 1U i 1i Ti HISTOLOGICAL | ESTIMATED i 1 1 1 | COKFIRWTK* | EXPOSURE | OCCUPATION ( | LEVEL 1 11 !1 Yea | 2000 ppa 1 j 1 1 l 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS Ref 1 baa 1| j wrong figures lI re first l( exposure. I| (Louisville lI Tlaea tl I 29.10.74, lI 12.1.75, \| (10.3.76 11 11 [ 1 Yes (1 (Ref 1 l1 \1 1 T Yes 11 \**t 1 J 11 J1 1 1 Yes (High LO yrs|l0 yrs as |Utility S Ref 1 * letter | reactor op. |Service op. of 26 April |(not cleaner(Bagger |1978 frts j- separate (Dryer op. jRiisaell A Park (crew cleaned (stripping op. | to J T Seawell (autoclaves) |3 yrs prior (of HCA t (service io ) 11 Yes |2000 ppa 1 t |tyre plant J____ ________ _____ 1 11 | (Charleston | 1 Dh 11T Hall i I1 ii ) 1 1 1 1 21.7.75 i1 Never diag- t1 t1 nosed as angiosarccsu of i1 liver. Infora- i1 i1 ation given In letter 22 Hay i1 1984 frcn i1 j J1 il i1 J A Salg. Accountant; ii ASL - No evi- i i J______________ i dence of VCH _________i exposure, j__________________ SL 063977 Page J>Z UK System of dates USA - Sheet 3 LIVER Angiosaroasm Cases - (Review Date: 1 Jan 1990) DAY - NOtmt - VTJtH r!-------------------- 1 1 1------------------ 1-------------------- 1---------------------- i i i---------------------------- 1-----------------------1------------------------1----------------------------1--------------------------- l 1 2 | 3| 4 | 5|6 | 7 8 1 9 | 10 | 11 | 12 | 13 14 15 | 16 ------------------------- 1-------------------- 1------------------ 1---------------------- 111 [i 1 COUimtV ARD I RIME OR REFERENCE j IHITIALS NO | ------------------------- 1 1 16 (Janes DATE OF BIRTH 04.11.27 COMPMTV BPS FACTORF Louis FUST FC | DATE OF EXPOSURE j DIAGNOSIS 1 1 1 08.05.50 | 00.00.69 1 Howard ville 1 1 1 _________11L P1 1----------------------1-----------1------------- 1----------------------------|----------------------------- 11 11 11 AGE AT | FEARS OF | FEARS OF DIAGNOSIS j EXPOSURE TO { EXPOSURE j DIAGWSIS j DATE dr jHISTOLOGICAL | ESTIMATED DEATH |CONFIRMATION | EXPOSURE | j LEVEL | OCCUPATION | | OTHER | CAREER ( HIGHLIGHTS | OTHER CONORS 1 1 41 { 19 I 1 | 04 1L 27.03.69 Fes i---------------------- ------------------------j1-------------------------- 11------------------------------- | 1951-4 VCH (fro* 1954 {Table 4 in li 1 polyaer- |onwards In | Wagoner i 1 II 1 1satLon {fcray and other{Testjjnooy to i 1 Ii 1 |servlce. |0S Senate I 1 II 1 {46-50 A ray {Confirmed in I l ___________ I II Louis 1 Ii 1 ll 1 ii I 1I 1 III 1 1 f |H N Johnson 1 { jltr 07.06.78 1________________________ _ .. _..1. _ 1_ 1 | 1--------------------------- Tea | ( | 17 |peerenboc|06.05.31 ] BFG ville 23.06.55 | 11.10.74 | 43 ( 19 1 19 16.10.80 on 11.10.74 | | | iDr A H Johnson f il i II III III 1 1 but no J | | pcwt-aorteB | j | letter of 24.2.81 cc l II f iI III III 1 1 16.10.80 | | | 1 11 firmed death 6 years after l lI iii 18 J Charlie |Z2.04.28 | BFG lUrthur j) 1 11 III ii {Avon Lake) 15.09.54 j| 11 00.00.75 1 | 1 1 46 21 1 i | 13 1 1 1 02.tl.75 | | 1 Tea 1 11 diagnosis 1-1-_--_-_--_-_--_-_--_-_--_-_--_--_-_-_1-_-_--_-_--_-_--_-_--_-_--_---------- [-1-------------------------1 |l3 fra Idavy | Confined in |autoc leanerf f A I Johnson |U jr* oo J ( Itr 07.06.78 1 11 ill 11 II 1 1 1 | jEstot [Tyre Store | Also Rolling 1 J IpJaatlcteerj ( Stone nag. 1 11 11 1 1 | [& Carboset | ) 15.01.76 1 11 1II1 I1 1 11 11 II II 1| 1 I1 1 1 | 1operation | | 11 11___________________ 1_ 1_ ------------------1---------------------------1-----------------------1------------------------ f--------------------------- 1----------------------------- - 1 1)111 29 fVirgil (DC.00.15 f UCC {Christian | ) (s Chatrle-J 00,00.43 J ator | 19.06.75 f 1 60 32 | 32 06.04.76 f fes |2000 ppm J 1 | )f | | /WHJlwpart {Sun Gazette III ii 1 1 | III |21 June 1975 III it 1 1 ) III (Charleston ill 1i 1 1 1 III lOailr Mail ill ii i______________________________ ____________ _______________ ii lit II / 1 III 1 1 20 | (11.08.17 | Goodyear (Niagara | 00.00.55 30.01.76 | 58 I1|11| lit ii i ill ii i 21 (Chester |02.09.09 | DCC |S Charle-j 00.12.46 Early 77 | 67 1 1 III (21.7.75 i Ilf 1 1 1 II 1 1 1 | II) (HOISH letter 21 ( 18 30.01.76 j Tea j f j (of 25.10.79 1 j 111 J i 1 1---------------------- f------------------------1---------------------------- 1----------------------------- l i ill i 30 | 22 32.01.77 f Tea | | ( (28 yrs with |ttinkle | | ) stcn | 1 1 | l{( jOCC at SC III II 1 1 | 1(1. (Retired III II 1 1 | III {News release III II ------------------------- 1111t 11 ______________ 1______________ _________________ 1_____________ 1 III 123.2.77 L--------------------------------------------1--___________ 111 SL 063978 USA - Sheet 4 LIVER Angios&rcaaa Cues - (Review Date: l Jan 1990) UK sjstea of dates MY - MONTH - YEAR 1 1! 11 1 2 j3| 4 |5|6 ill ------------------------1 ! 1 II 11 1 11 1 1 comm md | mis c* | cm op | | REPtREHCE jnrmiis j BIRTH1 COMHT i P4CT0BT | | post vc OPOSDM HO j || || ------------------------1------------------1------------------ 1------------------ 1 22 | 102.10.23 | BFG (Louis- 1 | 11.07.47 I 1 1 1*11 le | III II III II III II III II 11 1 7 | 0 | 9 | 10 111 ii 11 DATE OF DIAGNOSIS 00.01.76 AGE AT | TEARS OT [ TEARS OF DIAGNOSIS j EXPOSURE TO | EXPOSURE j DIAGNOSIS j DATE Of DEATH 1 t 52 | 29 1 i | 28 04.12.76 11 11 11 11 1i 11 12 | 13 | 14 |1| 11 11 HISTOLOGICAL | ESTDBTH) | corfirhatior j exposurej occupation | i LEVEL j ij1 I Tea j 1 ) il i1 ii iI II 1 | 1 1 | | I 1 i i i i t I 15 I 16 OTHER career HIGHLIGHTS OTHER OJWBTTS Louisville Tina 26.1-76 said be was the I Oth AS vlet is t Bells Laos of whoa B had died b| 26 l.76 In bis letter oi 16.09.01 Dr H R Johnson confIras this is tbe case described bf Darmaher Tnoburro & Van Ld Feb 1980 An J Medicine VoI 70 p280 23 00.00.23 Great Fitchburg 08.09.Se 06.04.73 SO Aaerican Hass. Chaaical Gcnpanf 14 06.04.73 (24) Deleted 1990 bf B Bennett: Not anglosaro but conflraed Cbolaogiosaro (25) ii i i >i i i Renewal froa register conflraed in Kuinaki letter of 5 l ll I I i ii l I i______________ i____________i__________ j______________ i--------------- S6 063979 R N Uheeler |letter of j 20/2/79 and j Rose Kaainski | letters of |26/2/79 and |S/l1/60 Page ."5^ LIVER Angiosarcoma Cases * (Review Date: 1 Jan 1990) (JK system of dates - DAY - NQMTH- YEAR USA - Sheet 5 i 2 3 4 56 7 a 1 9 10 11 12 13 14 15 16 COUNTRY AMD REFERENCE MO MATS OR urmiLS DATE OF BIRTH CGWMT FiCTORY FIRST VC EXPOSURE DUTY OF DUGRSIS AGE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS YEARS OF DATE OF EXPOSURE | DEATH HISTOLOGICAL COHFIRfUTlOM ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER cowmrrs 26 John Berrj 07.07.23 BFG Louis.ilia 03.10.<7 00.00.77 (19 to 2 lean after death) 52 (death) 2a (death) 18 u.02.75 Yes Exposed in Various johs some degree la PVC to 22 plants from cbeaica3s cold nxa to but anhn paste exposure recovery to was to VCH, PVC charging probably operator to high paste charging. Ill August 1%S. Terminated employment Jan 1966 R Kaminski letter of 26/2/79 and Prof. Tarturro letter of 9/1/79 JL Forrest 11.05.16 IICC S Charie 01.07.41 stoo 30.11.78 62 37 20 25.11.78 Yes (HIOSH sara 27 and C Daily HaU 25) High Operator to 10.10.76 Exposure In R N Wheeler bulk and Itr of 4 Jan dispersion PVC 1979 and manufacture Charleston Dell I HaU 30.11.78 and R Kanlnsfcl 26/2/79 2fl 11.04.17 1NX S Charle 00.08.44 03.11.78 61 34 33 03.11.78 Yes ston R Kaminski letter of 6/4/79 29 12.10.07 UCC S Charle 00.05.42 00.03.80 72 38 16 01.03.80 Yes R Kaminski ston Letters of 19th June 1980 ______ S. 5tb Nov 1980 wn30 22.07.22 Tenneco ElemLogton 11.06.64 30.12.80 58 17 15 30.12.80 Yes 6 - Unknown Maintenance Chemicals I 9 - Nlnlnal Mechanic l 6 yrs I Elsewhere I li |rs l Boiler house 1 Operator 1______ _____ , _______ i i i _______ 1________ 1 _______ 1 9rrs _________ SL 063980 USA - Sheet b LIVER Angiosarcoma Coses - (Review Date: 1 Jan 1990) T" 10 UK system of dates MV - MOUTH - YEAR 12 I I I15 16 COUKTRY HMD REFERENCE NO ItWE OR INITIALS DATE Of BIRTH OOtffANT FACTORY FIRST TC j BATE OF EXPOSURE | DIAGNOSIS oa.n.B OCC 5 Charle ston 12.05.46 01.06.81 AGE ET DIAGNOSIS 57 TERRS OF EXPOSURE TO DIAGNOSIS 35 TERRS OF EXPOSURE DATE OP DEATH 11 02.04.82 HISTOLOGICAL j ESTIMATED | CONFIRMATION j EXPOSURE j OCCUPATION j LETEL | -------------------------- (- OTHER J OTHER CAREER | CatCTTS HIGHLIGHTS j --------------(------------- (High (But (Chemical {not as bigbfOperator in |as reactor (charge (cleaner |reactor /would | (experience)| (Worked as | |labourer | |frcw | (June 1941 ( j to Hay 1946( jand may | |have ( (cleaned | jreactors Inf that tiae Froa 1959 to (Dr Dace; 1976 Aliphatic)letter Chemicals fit.10.8) and operator and |R N Wheeler Iron July 1976(letter of to date |9.11.81. Foreman Aliphatic [Also Dr Dace; (letter of Chemical J07.03.fl3 re Operatloo |date of death. I l 32 C M Giroux 22-02-08 Monsanto Springfield 15-10-51 00-07-79 Hass 14 (Id PVC autoclave area) 17-05-BO An autopsy The death 1940-1951 was done and certificate|Various Jobs f baediate gave {in polymer cause of Mr Giroux' (nanufacture death given usual (BtTTVAR as occupation |LUSTRE2 "AngiosarccMB1* as Settle (1951-1964 operator" |Various Jobs( | in and "chealcals |aroui>d PVC industry", {autoclaves |1964-1973 (Various (clerical (Jobs Ln PVC (polymerisation |facility/ | Retired (0I-0J-7J. Infcreation (given in (letter of 24 (February 1902 |fro* Dr (Walter C | Barnes of (Monsanto (Springfield to |br A Muon of |Monsanto (Europe. I S Ferguson Jnr Ixxiisville 09-09-54 11-05-82 28 28 Alive f J_ _ _ L 1954-74 High 1975-82 lx*# {Multiple | jobs |including (Poly (Operator + Ipojycleaner. (Prof Taoburro (letter of J 12 Aug 1982 * | Dr 8 If Johnson j let ter of I28 Feb 1983. SL 063981 PtKJP - ' USA - Sheet 7 LIVER Angiosarcoma Cases - (Review Dale: 1 Jaouarj 2990) UK system of dales - DA - WKTU - VEAR r ---- -- ---- 1 l 1------------------- ------------------------------------------------------------------------- 1 J j * 56 a9 10 H 12 1 13 1 H 1 15 I 16 ------------------------ i-- -- -- 1 -- ___________ ___________ . ___________ 1 __________ ___________ 1 1 YEARS OF j HIST0- 1 1i---------------------1|------------------- 1 T------------- ------------------------------------------------------------- 1 i1 s1 j^" cowm and MIS OR f Dm 0F| FIRST YC |DTE OF 1GE AT EXPOSURE 1 TEARS Cf| DATE OF (LOGICAL |ESTDCATE0| OTHER i REfCHOATE HfTTULSf BIRTH COWART FACTOR! exposure (ouGMosrslDuaosis TO EXPOSURE | DEATH a*fd*- f other a**Errs no | ------------------------ 1 34 Hr __________ ____________ BPG DlAGNOSISf |atiov ___________ 1 ___________ 1 ___________ ___________ i__________ 1 1 " 21 T Louisville 19S5 03-ll-82| 10 04.08.83 (Vea LEVEL t f 1955-74 HIGHLIGHTS| 1---------------------1 1l-------------------------------------------------------------------------------- Pol, 1965 left |Dr M N Johnson letter of .1 Hov 1982, I (High Operator + BFG to |28 Feb 1983 mod 9 August 3984. I 1975-82 Autoclave became a i I Low Cleaner Clergxssn.| 1955-65 t 35 l I I 36 [ ! 1 1 1 1 1 1 09-03-J2 ucc S Cbarle- 23HJ7-44 18-07-83 aton 71 39 ___________ 27-08-32 The GeneralAshtabula N-06*56 |?ire and (Rubber Co 21-08-03 50 27 3? J Pafton 29.08.29 rc ( 1 l l l 1 l l i 38 .JWB 28.08.22 Mr Louisville 1953 06.08.84 54 Calvert Citr 00.02.63 19.01.84 61 31 20 SL 063982 14 18-07-83 Tes High fras |1944 to 1955. (lied fm 1955-1956 27 Alive Tea 22 06.08.84 Vea Moderate 1956-56 labourer 11956-57 |prod helper| (1957-70 (operator L970-TS (electrlctaof 1975-present - operator High Worked (regular If in PVC area (Id tbs (earlf days was a |reactor (cleaner (1953-75. 20 28.10.83 Yes High [ Normal l963 -19821 profession | [from helper| (to senior | |operator, | (cleaned j | reactors, | (stripping (| (recovery ( |areas as | |well as 1 (charging 1 joperator. j Dr Dace; letter of 5 September 1983. R U Laimdrie letter of 12 Sept 1983 spotted at aedicaJ Hay 1983. Testing ccvenced Ray 1983 Information given in letter 09.08.84 frcm Dr K N Johnson Thrombo cytopenia and leukopenia since 1978. Gold treatment for arthritis 1976. Under Dr's care about 6 Booths before death, had passed standard physical examination 3 aooLhs earlier. J Barr letters of 22.10.84 and 13.01.86. USA Sheet 8 LIVER Angiosarcoma Cases - (Review Date: 1 January 1990) UK systea of dales DAY - MONTH - YEAft COUNTRY AND REFERENCE HO MAKE OR INITIALS J Nemlce DATE OF BIRTH COMPANY Pantasole FACTORY Passaic FIRST VC 7|6 DATE OF AGE AT YEARS OF EXPOSURE 10 YEARS OF 1 12 1 13 i 1 11 i i (histo- | i DATE OF {LOGICAL |ESTDnTED| h J ! is 1 1 1 (other 1 16 | 1--------------------------------------------------------------------------------1 l 3 s' I DIAGNOSIS DIAGNOSIS TO EXPOSURE DEATH |CUtEER 1 other ccmnrrs DIAGNOSIS (ATM* (level \\ 11 i j i i (HIGHLIGHTS I _J___________ I n i--------------------------------------------------------------------------------- 1 (Never in hospital for any chronic or 24 29-06-B4 | Yes j Low 129.09.60 - |Worked |acute medical problems. Death certificate 1984 ll Il ii |Haj 66 IVLnrl | before j 1960 (Fabrication(with US | states cause of death cardio-pulmooary |arrest secondary to angiosarcoma of jliver. ii |Plant |Air |Letter of 15.07.86 from John E Ertel j | High |Kaf 66 - (Force, |of Pantasote with letter cf 24.02.86 11 jAug 70 (United | fram Dr Auerbach, Pathologist. t1 (UUUti (Wool I 11 |Resin |Dyers I 11 (operator land I ]1 ({inc Jul 66jofcanite ) 11 |- Sep 67 l I 11 |Reactor I I 11 (Operator) l I 1 1 Lo" |Sep 70-82 l 11 (ffonamer t 11 (Operator t j j Low j1982-83 l 11 jnili l 11 |Operator, l 11 (Calendar I 11 (Shop, untilj retir I I I I l l I l 40 PC |26.10.14 Gilmer Louis ville 22.05.42 1987 72 45 34 03-01-87 High Chemical 1942-1971 jltorker j1942-45 Low | 1975-1976 (Pormac j1945-76 Letter fr 10.3.87 Dr Dieti, BFG, R Buckley 2.02.15 Goodyear Niagara Fal Is 38 20.08.87 \ Yes High |1949-65 | Retired Letters frcm Prof Tanhurro I |Chemical Op/ 1977 University of Louisville, 1987 (Shift Sup/ | (Age 62) and Dr C i Johnson, Goodyear, 1988 (Foreman, |PVC Resin (production flediis |1965-77 NT Plant |Left PVC area for 6 Months in 1965J SL 063983 US ft Shfel 9 LIVER Anglosarcoaa Cases - (Review Date: 1 January 1990) UK system of dales DRY - NORTH - YEAR COUNTRY AND REFERENCE NO -- 2 3 4 56 -- -- _____________ ____________ ____________ -- 8 I ____________ 1 1 11 1 NAME OR DATE OF INITIALS BIRTH COMPANY FACTORY FIRST VC EXPOSURE VEARS OF DATE OF AGE AT EIPOSUJtE DIAGNOSIS DIAGNOSIS TO YEARS OF EXPOSURE DATE OF DEATH DIAGNOSIS -- -- --f 12 n 14 1 IS 1 --i--J-- HISTO LOGICAL ESTIMATED CONFIRM EXPOSURE OCCUPATION ATION LEVEL OTHER CAREER HIGHLIGHTS other cowers 42 Netful len 02.05.41 Cl Id Iksaonet 00.04.68 00.04.82 41 14 6 09.07.82 Yes High Labourer Ln Pot area: pot cleanou regularly Letter fron Dr Peter Hanill 13.04.89 43 J R 08.09.21 GenCorp Ashtabula 14.04.S5 26.11.8a 67 Succi (foraerly Ohio General Tire) 13 28 10.01.89 Yes PVC Resin Retired Letters fra Roy H Johnson, GenCorp Plant: 01.01.84 08.05.09 and 30.05.89 High Maintenance Cleaner 1.6 years Shift Nedim Mechanic 2 years Plant Lew Electrician 24.10 years SL 63984 Page 7' * YUGOSLAVIA LIVER Angiosarcoma Cases - (Review Date: 1 Jim 1990) 10 13 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY YEARS OF FIRST VC DATE OF AGE AT EXPOSURE YEARS OF FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTO LOGICAL ESTIMATED coKmm- EXPOSURE AT10M LEVEL IS OTHER CAREER HIGHLIGHTS OTHER OFtOTTS YUGOSLAVIA OS.04.14 Jugo VI all Split 00.00.53 08.04.73 59 20 OB.D4.73 S1RIC et al paper Env Health Perspective Vol 1/. pp 189-192 1976 15.11.31 Jugo Vinil Split 00.00.50 12*07.73 23 12.0/.73 21.12.31 Jugo Vinil Split 04.06.54 U.01*76 45 11.06.30 Jugo Vinil Split 15-12.58 03.09.70 22 11.01*76 03.09.7B VC* Production VCM Production *Iu his letter of 3 Oct 1970, E>r Spirt as of NIOSH changed the status of Case 02 to VCH production ea*>lnjee. Dr Spirtas also notified a new Case 03 also a VCM product ion worker. Rose Kaminski letter of 19 June 1980 and 1ARC letter of l April 1982 -J__________ t__________ L_ _J__________ L. SL 063985 Page J|0 Incidence of ASL Cases Per Annum - By Date of Death 1955 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 19/0 1 2 3 4 5 6 7 0 9 1980 1 2 3 4 9 6 7 8 9 Total 1 0 1 0 0 0 1 1 0 2 0 0 1 5 3 2 3 5 8 5 11 11 8 10 5 10 5 3 10 8 8 11 3 7 5 193 TABLE 1 (Review Date - 1 Jan 1990) NOTES 1 Does not include Italian 01. 2 The 1977 total now excludes US24, Cholangiosarcoma: deleted. 3 The 1982 total now excludes G26 Alcoholic Cirrhosis: deleted. 4 Does not include the following who are still alive, so far as known: Fr15 and 28, US33 and 36. SL 06*3986 Page Distribution of ASL Cases by Country USA W Germany Prance UK Canada Sweden Italy Yugoslavia 00 * * * * * a * 07 * * * * * 28 ** 16 13 5 *** 6* (J * * * * TABLE 2 (Review Date 1 January 1990) ie Western Europe North America Rest of World Total 96 52 9 15/ -- Czechoslovakia lie 1 g i urn Norway Spa i n Tota 1 157 * Omit 1tOl - atypical case of PVC bag extruder. ** Includes Frl5 and 28, US33 & 36, who are still alive, so far as known. * * * Inc1udes one monomer worker. **** Includes two monomer workers. ***** Excludes G26 and US 24: deleted. SL 063987 Page Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1990} (a) W Europe Ot the 96 cases in W Europe, 79 have occurred in clusters at 10 factories. Of the 37 German cases, 34 have occurred in clusters at 4 factories. ASL Cases Dynamit (now Huls), Troisdorf, Germany BP, Barry, UK Atochem (formerly Chloe Chimie, formerly RP), St Fons, France Wacker, Burghausen, Germany Atochem (formerly PCUK) Brignoud, France Kemanord, Sundsvall, Sweden ICI, Hillhouse, UK Solvay, Tavaux, France CWH/Huls, Marl, Germany Lonza, Waldshut, Germany 10 11 11 10 8 5 5 5 3 3 79 NB: There are 32 pre 1962 PVC plants in W Europe; 20 of these have had ASL cases (Ref Table 0} (b) N America Of the 52 cases in N America, 41 have occurred at four factories out of a total ot 55 factories. In N America 41 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawin igan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 9 _5 41 NB: There are 29 pre 1962 PVC plants in N America; 13 of these have had ASL cases (Ref Tables 9 i 10) (<:) Rest of World The 9 ASL cases are believed to be in one cluster of 4 and two clusters of 2 cases. SL 063988 Page TABLE 4A (Review Date 1 Jan 1990) Latency Periods (Years from first Exposure to Diagnosis) Country No of Cases Total Years Averaqe W Europe Belgium France 2 35 17.50 28 795 28.39 * Germany Italy Norway Spain Sweden UK 37 765 20.67 * 6 127 21. 16 1 22 22.00 1 25 25.00 5 122 24.50 16 376 23.50 * 9b 2267 23.61 W Europe Average N America US Canada 39 1002 25.69 * 13 314 24.15 * 52 1316 25.30 N America Average Rest of World Czechos Lovakua Japan Yugoslavia 2 3 4 9 30 15.00 59 19.66 85 21.20 174 19.33 Rest of World Average Summary W Europe 96 2267 23.61 N America 52 1316 25 . 10 Rest of World 9 157 1 74 3757 19. U 23.92 * World Average * oft he count rie s with > 10 cases, France, USA & Canada have an average latency period above world average; Germany Pcluw world average. SL 063989 UK DISTRIBUTION OF LATENCY PERIODS -- -------------------- r 1 0-9 yrs 1 10-14 yrs 1 l 1 | Belgium 1l | Canada 1 t i. 1 3 1 | Czechoslovakia 1 i | France 1 1 | Germany 1i | Italy i1 Japan 15 Norway Spa l n Sweden IJK 1 USA 3 Yugoslavia (Review Date - 1 Jan 1990) TABLE 4B 15-19 yrs 2 1 4 11 2 ---- 20-24 yrs 25-29 yrs 52 3 10 10 6 22 30-34 yrs 1 4 4 --n 35+ yrs Tota L Li i i^ i 2 1 13 |1 12 11 6 | 28 | 1 37 1 0 ni Average Latency Period (Table 4A) 17 . 50 24. 15 1 3.00 28. 39 20.6 7 2 1. lb 12 1 ] 9 . bb 1 1 22.00 1 1 2 3.00 2 21 CJ 74.50 5 1 63 lb 23.50 7 9 8 b b 10 26. 10 4 4 2 1.70 TOTAL 2 13 35 37 37 19 14 15/ 7 4.0 3 SL 063990 Page -L (Review date 1 January 1990) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE LATENCY PERIOD YEAR OF FIRST EXPOSURE LATENCY PERIOD (NO OF YEARS) ARITHMETIC MEAN OF LATENCY PERIODS 50 1939 49 1940 298 = 37.25 48 1 37,21,37,41 8 47 2 32,38,45,47** - 46 3 38,14,32,42,45 4 28,11,24,20,24,34,39, 886 = 28.58 44 31 5 27,22,28,29,37 6 21,29,31,26,28,15,23, 30,35 42 7 29,24,29,28 41 8 28,24,34 9 30,26,20,38 559 = 25.41 1950 26,22,31,19,23,14,33 22 1 19,28,17,28,34,29 37 2 21*, 15 36 3 25,23,22,20,31,22, 32,30,23 . 4 21,21,25,25,21,28**, 22,34,34 1010 = 24.04 5 22,23,24,14,19,21,27 42 27** 24,28,30,33 6 21,12,27** 32,29 32 7 19,17,15,13,16,28,30 31 8 18,18,15,17,20,29,28 9 16,21,25,27 598 = 19.29 1960 13,18,21,25,24,25 31 1 15,16,16,16,19,19,12 27 2 13,18,17,12,18,21,26 26 3 16,17,20,21,25,25,26 4 16,17,25 322 = 18.94 5 11,19,20 17 6 9,18,21 22 7 16 21 8 18,5,18,14 9 13,16 1970 1 17 2 16 3 4 TOTAL 157 CASES 84 = 14.00 6 VIOLA 3757 = 23.92 157 MALTONI GOODRICH * Aerosol can filler G 03. ** The following are still alive, so far as known Frl5 and 28, US33 and 36. SL 063991 Page (Review date 1 January 1990) TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION MAN POSSIBLE LATENCY PERIOD YEAR OF FIRST EXPOSURE LATENCY PERIODS IN WESTERN EUROPE NORTH AMERICA ROW 50 1939 49 1940 48 1 37,41 21,37 47 2 47""' 32,38,45 46 3 38,45 14,32,42 4 28,44 11,24,20,24,34,39 5 27 22,28,29,37 6 21,29,31,33 26,28,15,23,30,35 42 7 29 24,29,28 41 8 28,34 24 9 30,26 20,38 1950 26,22,31 19 1 19,28,34,29, 17,28 37 2 21* 15 23,14 36 3 25,22,32,30,23 23,31 22,20 4 21,21,25,25,34,34 21,28** 22 5 22,23,24,27**24,28 14,19,21,27,33 30 6 21,12,32,29 27** 32 7 19,17,15,13,28 30 16 31 8 18,18,29,28 15 9 16,21,25,27, 1960 13,18,21,25,25 24 1 15,16,16,16,19,19 12 27 2 13,18,17,18,21,26 12 17,20 26 3 16,17,21,25,25,26 20 4 16,25 17 5 11,19 6 9,18,21 22 7 16 21 8 18,5,18 14 9 13,16 20 VIOLA 1970 1 2 MALTONI 3 TOTAL CASES 96 52 9 * Aerosol can filler G 03. ** The following are still alive, so far as know Frl5 and 28, US33 and 36. 063992 Sh Page !:7 (Review date 1 January 1990) TABLE 4E PLANT START UP DATE LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) NO OF AVERAGE CASES LATENCY PERIOD TROISDORF W GERMANY LOUISVILLE USA SHAWINIGAN CANADA BARRY UK ST FONS FRANCE BURGHAUSEN W GERMANY 1954 12,13,16,16,18,19,19,21,23,25,28,29,29, 5,23,16,34,18 1940? 12,14,15,19,19,20,24,27,28,28,28,29,29, 31,45 1943 11,12,14,21,22,23,24,24,26,28,42,37 (1941?) 1948 9,17,18,28,31,33,18,19,18,21,32 1939 21,28,29,37,38,27,41,34,44,34,47 1933 17,21,22,25,24,13,21,32,30,30 18 15 12 11 11 10 20.22 24.53 23.66 22. 18 34.54 23.50 SL 063993 i Page (Review date 1 January 1990) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) 1---------------------------------------------| YEAR OE FIRST TROISDORF -------------------------------- 1---------------------------- LOUISVILLE SHAW INIGAN BARRY ST EONS | EXPOSURE W GERMANE' USA CANADA U K FRANCE 1939 1940 1 2 J 4 5 6 7 -- 20 28,29,27 29,28 21 14,42 11,24 22,37 26,28 24 57,4 1 47 38 44 29 'SC PwKmL C; .N W GERMANY 8 9 1950 1 2 29 24 19 15 31,33 I 28 23,34 3 23 31 23 25,32,30 4 21,25,34 28 34 21 5 23,28 14,19 27 22,24,30 6 12,29 32 21 7 13 17 8 9 1960 1 2 16,16,19,19 18 12 12 18 21 3 4 5 6 7 8 9 1970 1 2 ______________________________ 5,18 16 17 19 9,18,21 18 ____________________ ___________________ 13 SL 063994 Page (Review dace 1 January 1990) TABLE 4G PLANT START-UP DATE LATENCY PERIOD OF ASL CASES NO OF IN SPECIFIC PLANTS(4-9 CASES) CASES AVERAGE PERIOD S CHARLESTON USA BRIGNOUD FRANCE SUNDSVALL SWEDEN 1939? 1950 1945 24,30,32,32,34,35,37,38,39 11,16,18,26,30,25,34,45 16,19,27,29,31 9 33.44 8 25.62 5 24.40 NIAGARA FALL! USA 1947 15,17,21,23,38 5 22.80 TAVAUX FRANCE 1953 19,16,21,26,25 5 21.40 HILLHOUSE UK SPLIT YUGOSLAVIA 1940 1950 28,25,28,25,26 20,20,22,23 5 26.40 4 21.25 SL 063995 TABLE 4H Rage (Review date 1 January Ly90i LATENCY PERIOD OF A5L CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) ----------------------------- ,------------------------- -- ----------------- 1 YEAR OF |S CHARLESTON BRIGNOUD SUNDSVALL NIAGARA! TAVAUX H1LLHOU5E SP7I: FIRST EXPOSURE| USA FRANCE SWEDEN FALLS 1 FRANCE UK. YOG'JSPAV ' 1 ------------------------------11 1939 | 1940 | 1| 37 USA i 11 1 1 ! 1 i i i 1 2 | 32,38 1i 3 | 32 45 1I 4 | 24,34,39 5| 1 28 27* 1 1 6 | 30,35 31 15,23 | I 1 v| 11 i a1 29 1 1 11 ____________ 1!______________ 11 91 26,30 1950 1 2 | j i 34 ------------------------------i1------------------------- 31 4j 51 19 38 | 1 12 1 I 11 1 1 21 | i 1 23 * i 1 1 11 ( 20 25 22* ! 61 11 71 ----------------------------- 1 8 9 1960 1 I 1 j j 18 16,25 1 19 1 ! 1 1 1 28 1 -- 1 20 1 1 1 21 1 26 j 1 ____________ 1--------------------- 31 4i 5| 11 61 7| ----------------------------- i1------------------------- 8I 9 1970 1 j 11 21 ----------------------------- 1------------------------- |16,21,25 25,26 | 16 1 1 1 1 1I 1| 11 11 11 1i 11 11 ___________ 1___________ ____________ 1--------------------- *Monomer worker SL 063996 Rage TABLE 5 (Review Date - 1 Jan 1990) 1955 7 1961 2 4 7 8 t9 19/0 1 2 3 4 S 6 7 8 9 1980 1 2 9 4 S 6 7 8 9 Annual Incidence of ASL Cases (Date of Death) by Geographical Area Western Europe North America Rest of World Annual Total Cumulative Total 1 1 1 1 1 1 5 12 11 32 41 14 32 64 63 fe 2 72 8 64 5 3 73 62 7 10 1 J 7 41 1 1 1 1 12 1 5 5 2 3 5 38 5 1 11 2 11 8 1 10 S 10 5 3 10 8 18 31 3 7 S 1 2 3 4 b 7 12 1S 17 20 2S 33 38 49 60 68 78 83 93 98 101 111 119 L27 138 14 1 148 1 S3 Key Events Viol a Ha 1 ton l Guodiich 1 | 1 ! | | [ TOTAL 94* * * 50** J_______________________ _ ________________ * Ora i t.s It. 01 bag ext ruder 9 1 S3 ___________________ _____________ ** Hoes not include the following who are si ill alive, so fur ns known: i'rlh and 28, US Id ts. it. NOT!'.: G7f> and lfS24 deleted. SL 063997 Page (Review date 1 January 1990) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING It. 01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD 1955 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 Viola 1970 1 2 Maltoni 3 Goodrich 4 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 9 TOTAL Cl C2 US 8 C3 US 5 Cz2 FI C4,C5,US4,US7,US10 G1 US12.US16 Swl US11 G2 Nl,Sw2,UKl,It2 C6.US2 C7 G3* C8,US1,US3,US23 Yl,Y2,Czl G4,G5,UK3 C9.US13 F2,F3,G6,G7fG8,It3 Bl,F4,F5,F6,F7,Sw3 F8,F9,G10,G11,G12,Sw4 F10,F11,G9,G13,G15 G16.G17 F12,F13,UK4,UK5,G18 UK6, UK7,G19,Sw5,G20,G21US It4,F14,UK8,G22,G23 UK09,It5,F17,B2,G24,G25,G30 UK.10 ,F16 ,F18 ,G27 ,G29,G35 UK11,UK12,F19,F20,G28,G33, G34 F21,UK13,It6,It7,G31,G32, G36,G37,G38,G39 F25,F26,UK14,UK15,UK16 F22.F23,F24,F27,Spl,UK17 US6,US9,US18,US26 US19,US20,US22, C10.US21, US27.US28 US17, US29, US30.US32 US31.US42.C12 US35, US34, US38 US37.US39 Cll US40.US41.C13 US43 Japl Jap2,Y3 Y4 Jap3 94** 50** 9 * Aerosol can filler (G3) Does not include the following who are still alive, so far as known: F15 and 28, US33 and 36 NOTE: G26 and US24 deleted. 063998 SL Page (Review date 1 January 1990) TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It.01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD Viola Maltoni 1939 AO 1 2 3 A 5 6 7 8 9 50 1 2 3 A 5 6 7 8 9 60 1 2 3 A 5 6 7 8 9 Frll,Frl6 Fr28** FrlA,Fr2A UK1,Fr23 Sw2 Frl ,Fr3,SwA Sw3 Fr9, Fr17 Frl2,FrA Fr7,N1,UK8,UK9 Swl,UK5,Fr20,G30 G3* GL5,It3,G31,G33,G36 G7,G8,G19,G38,Fr27,UKA Gil ,G16,G18,G23,G28, G32,Frl5** FR10.G1,G3A.UK15 Fr8,GA,It2,G2,UK12 Fr6,Bl,Fr22,It7 Fr2,ItA,Frl9,Fr21 G5,G13,G25,G28,It6 G9,G10,G12,G17,G20,G22 G6,UK6,G21,B2,G29,Fr25 Frl3,Frl8,Fr26,UK7, UK16.UK17 Sw5,Spl Fr5,UK11 UK3, UK10.UK1A its UK13,G35,G39 G2A.G37 C3.US27 US13, US29.USA0 C2,US19.C11 Cl,C5,US5,US7,US28,US35 CA.US3.US9.C12 C7,C9,US8,US11,US21,US31 C6.US22.US26 US1 US12.USA1 US16 Y2, Cz2 US10, US32 USA CIO, US37 Japl,Y1 US18.US33** Y3 US2.US17.US20,US3A,USA3 US36** Cl 3 US23 Czl Jap2,YA US39 C8 US 6 US38 US30 Jap3 USA2 70 1 2 3 Total 96 52 9 * Aerosol can filler (G3) '* Frl5, Fr28, US33 & 36 are still alive, so far as known NOTE: G26 and US2A deleted. SL 063999  jge (Rev.ew . Jar.art TABL". : WESTERN EUROPE ?V~ PRODUCERS - START-7? TATES vs >SL ~A8E3 yMITTIN: ^TART- JP| COUNTRY NAME | 1QMFANY NAME YEAR 1. ii -* * j . !*st jorranv I BASF 1 :5i3 t m? st nu&ny |Hacker i1 i LOCATION [ Ejdw: jsr.aYt"-. 1Burgnausen j T i SSL 'ASE NUMBER i YF 15 ~. 4, ;- , . 1 : ?33 iitajy (Montecatini ! Acna 1 1939 | France j Rhone-Poulecc/ |St Eons r3,C9,.4 ^ 1 IChloe/Atochefn | 1940 1 United KinadanllCI/EVC (Runcorn (Closed i948) i 1 United KinadomllCl/EVC iHi1Ihouse (01,34,; 2jl 6,: 7 1 -t*t, . *1 , i i . " . , V 1 L945 1 Sweden 1Kemanord/Nobe1 ISundsvaiKStockvik)lul.02.03.04.05 t ^1,45,4 i, 4r;, c4 I 1946 (France (Rnone-Poulenc (Roussillon ! o; Ufa | 1948 |United Kingdom|BP Chem/ICI/EVC|Barry (03,05,06,07,08,09 166,51,-32,63,71 ,6-; 1_______________ J_______ J____ iu, n,13,14,15 166,65,-3,36,26 IWest Germany ICWH/Huis iMari i 09,10,29 !61,mg2, 1 1949 1Belaium Isoivay 1JemeDDe i01.02 158,62 ! 1950 |France |PCUK/Atochem | Brignoud |02,04,05,06,12,19 169,49,65,58,49,53, 11 1 120,24 151,43 |France |Rhone-Poulenc/ (St Auban (07,22 |50,58 1 Ichloe/Atochem I 11 (Holland (Shell (Perms, Rotterdam ( 1 (Norway 1 Norsk (Herora, Porsarunn (01 (50 1 1951 (Switzerland Ihonza/ICI/EVC ISins 1 _________________ | 1952 I Italy |Montedison/ |Temi |07 ! 58 1 iMonlefan 1 l _________________ 1 Italy IMontedison/EVC 1 Porto Harahera 102,06 157,50 1 1953 (Austria lHalvic/Solvay 1 Hallein I 1 1 France ISolvay iTavaux (08.13.18.25,26 |57,o3,63.62.53 1 Italy . ISolvav 1 Ferrara |03 153 (Spain (Rio Rodano 1 Hemanl (United Kingdom j BXL/BIP/NORSK (Aycliffe I I 1 1 IWest Germany iHoechst iGendorf 118 155 | 1954 (west Germany |Dynamit/Huls |Troisdorf 101,02,08,12,16,17 |56,57,54,61,55,61, 1 | (since 1.1.89) 1 119,20,21,22,27,30 154,61,62,61,55,51 i 1 1955 ISMjn 1 1956 | Spain 1. 1 (Monsanto IberiaiNonzon ICaiasa 1 . .. 134.35,36.37,38.39 156.68.53.69.54,68 1| 1 _____________________ 1. 1 1Hisnavic/SolvaviTorrelaveqa 101 164 1 1958 Iwest Germany (solvay 1Rheinbera | 1960 |Italy |ANIC/SC Ravenna 1 1 1 1 1 1 l/EVC 1 Ravenna 104 159 IWest Germany ILonza/ICI/EVC lUaldsbut (06.13.28 /162 60,60 1 1961 1 Italy 1 1962 IPortuaal IMontedison/EVC 1 Brindisi (Cires lOnorto 1 1 _________________ _________________ | 1965 1 France 1Rbone-Poulenc iMontlucon 121 ]59______________________ 1 Italy iPozzi 1Ferrandina J J________________________ 1 Italy (Pensac 1 IWest Germany 1 Hacker iKira, Venice 1Coloane 105 1 167 ............ . ! 1 1966 Iwest Germany IHoechst | 1967 1 France lAtochen 1 Knansack(Frankfurt >105* iBalan 1 160 ____________ _____ I 1 Spain (Rin Rcxtano 1 Miranda de Ebro 1 1 1 1 Greece 1 Esse PaDtsas iDiavata Salonika 1 1 1968 |Belgium iBadiptul 1 Antwerp 1 J_________________________ j 1969 1 United fcinadcml Vmatex/Norsk iStaveley 1 J_________________________ 11 taly__________ (Rumamca/EVC ICaaliari Sardina I____________________|_______________ _ 'Tint, Inued SL 064000 Table 8 - Continued WESTERN EUROPE PVC PRODUCERS - START UP DATES vs ASL CASES (OMITTING GO 3 6 It. 01; 1--------------------------1-----------------------------1-------------------------------- l T s H % H | COUNTRY NAME | COMPANY NAME | LOCATION | ASL CASE NUMBER 1 YEAR OP 1 YEAR i i i J _L_ 1st Exposure 1 | 1 | 1970 1 Italy 1 SIR 1 Porto Torres Sar _l X____........ ....................... l lUnited Kingdom]ICI/EVC [Runcorn ! _L_ i | 1971 1 Spain 1Hisoavic/So1vav1Martore11 1 1 _________________________1 1 Sweden iKemanord/Norsk Istenunesund 1 _L___ j [United Kingdom)BP Chem | 1972 1 Finland 1Pekema 1 Ho Hand 1DSM 1 Baglan Bav 1Svartback 1Beek Limbure 1 _J _J 1 _________________________1 J__ --I J_ _______________ 1 | 1976 |France 1 |Soc Art D'vinyl|Matingarbe 1(CDF) 1 1 ! I J__ l i 1 1977 1SDain 1 Monsanto Iberia 1 Tarragona 1 _l___________________________l | 1982 |West Germany |ICI/EVC |Voslapp 1 1 l ]1 IWilhelmshaven 1____________________ 1 i 11111----------------------1---------------------------------------- --1 * Laboratory worker in Research Department SL 064001 Page (Review date 1 January iJ'-nj) TABLE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES 1------------------ i iSTART-UF | COMPANY NAME ; YEAR 1 1930 ? i*ucc i | LOCATION 1 | S Charleston 1 1 ASL CASE I NUMBER |07,13,iv , 11 , 27 I 1 YEAR OF 1st EXPOSURE 44 , 4 J , 4 J 4 b , 4 t ! 1 i ;1 i | Low 1 j Midland (made 123,29,31, J5 j 44,42,46,44 ; 1 1 j J.940 ? |*BFG 1 Saran copolymer) | 2 ( Louisville | 01,02,0j,04,05, 48,:;-, 15 , 5 2 , 1 -i, | 11 1 ! 1946 |*UCC/Dow 1 106,09,16,17,22, 1 o2 , * j , 6 0,5 b , 4 7, ! 1 126,33,34,37,40 47,54,55,33,4. | Texas City (Partially closed 1977) | | I 1947 I Goodyear | Niaqara Falls 108,10,11,20,41 46,51,46,55,49 ] | 1948 | Firestone/ ( Pottstown |12 49 | I Occidental | Uniroyal | | Painesville 1 | i i 1 1 (closed 1975) | i | 1950 | Monsanto [ Springfield |32 51 1 1 | 1952 1 Dow 1 (Closed 1975 1 | Midland (No PVC since c 1975) 1 1 I BFG | Avon Lake 118 i 54 1 1 1953 I Diamond/BFG ( Deer Park | j_______ .____ . ______ | 1954 | General Tire/ ** | Ashtabula 136,43 56,55 I DiversiTech | (Closed 1983. Reopened 1986 by Vyqen) ( 1956 I Air Products | Pensacola (Pace) | j___________ .___________ I Atlantic Refininq | Brooklyn(Closed late 1960s) J I Borden | Leominster (Closed 1984) i_________ _ _______ | Conoco | Hebronville (Closed 1975) i 1 BFG | Niaqara 1 i_____________ _ | Great American | Fitchburg |23 58 1 Plastics I Hooker 1 I Pantasote | 1957 1 Atlantic Tubinq I (Closed 1983) 1 1 Hicksville (Closed 1980-81) 1 Passaic(Closed 1984) 39 | Cranston (Closed 1967) . ______________________ J . 60 | Tenneco/ | Flemington NJ (30 59 I Occidental | 1958 I Keysor Century | Air Products 1 (Closed 1985) I 1 Sauqus, Cal | | Calvert City(Paducah) 38 . _________________ .. 63 1 | 1960 | BFG 1 (Closed March 1982 Re-opened October 1983) I Long Beach, Cal (No PVC now. 1 I Borden 1 Formerly shown as Watson) 1 Illiopolis | I 1962 I Tenneco/Occidental| Burlinqton NJ 1 | 1963 ( Conoco/Vista | Aberdeen, Miss | 1 Stauffer I 1965 | Conoco/Olin 1 Lonq Beach, Cal (Closed 1982) | Assonet, Mass j 42 68 1 1 (Closed by Olin 1975) 1 Ethyl 1 Baton Rouqe (Closed 1984) | 1966 | Diamond/Georgia | Delaware City | I Gulf | 1 |Gen Tire/Pantasote 1 Mt Pleasant W Va |(Closed 1982) I BFG | Henry, 111 1 | Stauffer/Formosa | Delaware City (Sold to Formosa 1981) | 1967 | Allied/Robintech/ ( Painesville, 0. (No PVC made by Robintech. I Georqia Pacific | GP converted to polystyrene) 1 Hooker/'Occidental | Burlinqton NJ | } l 368 1Firestone/Occidentai PerryviiJe (Closed 1982) ________________- -- 6--= Continued SL 064002 Page TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES us ASL CASES START-UP YEAR 1969 1971 1972 1973 1974 1975 1979 1983 1986 COMPANY NAME BFG Goodyear/BFG Conoco/Vista Nat Starch Borden Atlantic Tubing/ Tallyrand Shintech Certain-teed Georgia Pacific/ Georgia Gulf Tenneco/Occidental Firestone/ Occidental Formosa Vygen ** LOCATION Pedricktown NJ Plaquemine Oklahoma Citv Meredosia, 111 Springfield Cranston RI (Closet ASL CASE NUMBER 1982) Freeport, Tex Lake Charles Plaquemine, La Pasadena, Tex Addis (formerly she Plaquemine) Point Comfort, Tex Ashtabula, Ohio as YEAR OF 1st EXPOSURE * My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. SL 064003 Page (Review date 1 January 1990) TABLE 10 CANAD JAN PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR COMPANY NAME LOCATION 1943 (19417) Goodrich Shawinigan (Formerly Gulf) (Formerly Shawinigan Ihemicals) (Formerly Canadian Re:sins & Chemicals) ASL CASE NUMBER YEAR OF 1st EXPOSURE 01,02,03,04,05 44,43,41,45,44, 06,07,08,09,10, 47,46,61,46,5) 11,12 43,45 1951 Monsanto La Salle (Closed 1( 375 ) 1957 Goodrich Welland (Niagara) 13 57 1966 Esso (Imperial Oil) Sarnia 1979 Diamond Shamrock Alb/ Fort Saskatchewan BF Goodrich SL 064004 Page (Review date i January 19Q0) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES -------------1---------------------- 1-------------------- --j------------------------- ----1-------------------- 1 START-UP 1 COUNTRY NAME | COMPANY NAME | LOCATION | ASL CASE | YEAR OF | YEAR 1 1 _J_______________ 1 NUMBER 1 1st Exposure 1 Pre 1939lEast Germany 1 State Company 1Schopau 1 _J 1941 1 Russia 1950 1Yuzoslavia 1 State Comps lJuzo Vinil Ivladimir et al 1 Split _____________ _J 101.02.03.04 1 53.50.54.58 1951 (Czechoslovakia!State Cornus 1Novakv 101.02 _1?.I,50 1955 lEast Germany 1 State Comps iBitterfeldt 1 ! 1956 1 Rumania 1 State Coraps 1Icechim 1 1957 1 Poland 1 State Coraps lOsweicim (Dworv) 1 _J |Rumania |State Coraps |Timaveni 1 1 11 1Turda 1 _J______ ___ 1958 1 Romania 1 State Comps iRisnov 1 1 I 1959 iHunearv 1 State Comps iBerente Borsod 1 1 1961 1 Rumania 1 State Comps iBorzesti 1 1 1963 1Yuzoslavia lOhis ISkooie 1 _J____ . 1965 iBulzaria !State Coraos 1 Varna 1 1 1967 1 Poland 1 State Comps iTamow l 1 i 1969 1 Russia 1 State Comps iDieriinsk 1 _J 1970 1 Rumania 1 State Comps iRimnicu Vilcea 1 1 1 Russia 1972 1Yuzoslavia 1 State Comps 1Volzoerad Ivinilolastika 1 Zadar _J 1 1 _J 1975 1 Czechoslovakia!State Comps iNeratovice _J l 1976 1977 1 Russia 1 State Comps iKalush Area ] 1 1Yuzoslavia iHip 1Pancevo l _L 1 Rumania I State Comps IRimnicu Vilcea 1 ! 11L----------------------------------------------- ------------- ---- 1----------------------- 1------------------------ 1 SL 064005 Page (Review date 1 January 1990) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR COMPANY NAME LOCATION ASL CASE NUMBER YEAR OF 1st EXPOSURE 1950 1951 1952 1951 1955 1956 1957 1960 1964 1966 1967 1968 1970 1971 1973 1974 1975 1977 Chisso Corp Kanegafuchi Kag Tekkosha Mitsui Toatsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosei Ryo-Nichi Nippon Zeon Nisshin Kagaku Kureha Kasei Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisso Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha Asahi Glass Toyo Soda Central Kagaku Toyo Soda Unknown Minamata Osaka Sakata Nagoya Yokkaichi Kikumoto Shibukawa Kambara Tckushima Uozu Takoaka Takeo Nishiki Naoetsu Ohmi Takasago Chiba Tokuyama Tokuyama Chiba Mizushima Tokuyama Mizushima Goi (Chiba) Kashima Kawasaki Sakai Chiba Kashima Yokkaichi Hayatsuki Sakata Yokkaishi Kawasaki Yokkaichi Kashima 02 01, 03 58 53, 65 SL 064006 l age (Review date 1 January 1990) TABLE I") SOUTH ANT) CENTRAL AMERICAN ETC PRODUCERS START-UP YEAR 1953 1 95A 1955 1956 1960 1961 1965 1966 1967 1968 1970 1971 1975 1976 1977 1978 1979 COMPANY NAME Monsanto Mexica Policvd Geon Do Brazil Elchlor/Solvay Electrochlor Viplastic Indupa PET Columbiana Carburo De Col Plasticos Omega S0C Paramonga Primex Policasa Petro Dow Polimeros Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Folychem Policyd PET Camacari LOCATION Lecheria (Mexico) Mexico Citv (Mexico) Sao Paulo (Brazil) Sao Caetano (Brazil) Capitan Bermudez(Argentina) Mendoz (Argentina) Cinco Saltos (Argentina) Cartagena (Colombia) Medellin (Colombia) Mexico Paramonga (Peru) Puebla (Mexico) Managua (Nicaragua) Conception (Chile) St Martin Puebla (Mexico) Guyanilla (Puerto Rico) EL Tablazo (Venezuela) Tlazcala (Mexico) Cubato (Brazil) El Salvador Coatzacoalcos (Mexico) Camacari Bahia (Brazil1 AST CASE NUMBER YEAR OF 1st EXPOSURE SL 064007 Page (Review date 1 January 1990) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP YEAR COMPANY NAME Mid 1950s ICI Australia 1960s B F Goodrich Late 1970s ICI Australia LOCATION Botany, Sydney Melbourne Laverton Melbourne ASL CASE NUMBER YEAR OF 1st EXPOSURE SL 064008 Page (Review date 1 January 1990) TABLE 15 MIDDLE EASTERN PVC PRODUCERS START-UP DATES START-UP DATE Sept 1986 COUNTRY NAME Saudi Arabia COMPANY NAME LOCATION National Plastic Company (Ibn Hayan) Arabian Petrochemical Company Madiant Al-Jubail Al-Sinahyah SL 064009 Page (Review Date 1 January 1990) TABLE 16 NUMBER OF FACTORIES IN THE WORLD PRODUCING PVC So far as known at 1 January 1990 (See Tables 8-15 of this ASL Register) Western Europe USA Canada Eastern Bloc Japan South and Central America Australasia Middle East CLOSED 1 20 1 - 1 22 OPEN 53 30 4 23 36 22 3 i 172 SL 064010 COiriDIITIU HOSLD UttiSTM <JP CP m op m uvn (is.) to tot SL 064011