Document wqwzJ8bz45veGOrkB0K9BMN7E
Chemical Manufacturers Association
May 11,1998
Dear Vinyl Chloride Health Committee Members:
Enclosed is a copy of the draft reproductive study from Huntingdon Life Sciences. Please review and send us comment on this draft study no later than COB Friday, May 29,1998. Huntingdon will then have thirty days to revise the study and respond to our comments. The final reproductive study is due to ATSDR by July 1998.
If you have any questions, please call Wendy Sherman at 703/741-5639.
Enclosure
Sincerely,
Burner
Cynthia Barrett Senior Admin. Asst. Vinyl Chloride Health Committee
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Innovation, Technology and Responsible CarC' At Work nno Wilson Blvd.. Armncton, VA 22209 Thci'hone 703-741 -5000 Fax 70 3-741-6000
BFG 003270
* Responsible Care APubltcCommrtmerrt
Huntingdon
STUDY NO. 96-4080
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
Reproduction Study
Unaudited Draft Final Report
Volume III of III
Submitted to:
Chemical Manufacturers Association Chemstar Department 1300 Wilson Boulevard Arlington, Virginia 22209
Attn: Hasmukh C. Shah, Ph.D.
Date: 5 May 1998
Page 1
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APPENDIX Y
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Huntingdon Life Sciences Reproduction Study
96-4080
Pathology Report Table of Contents
Page 1 Draft Final Report
Appendix Y
Adult Animals
Incidence Summary ofMacroscopic Postmortem Observations Pi Generation.................................................................................................................. 3 P2 Generation.................................................................................................................. 7
Expanded Incidence Summary of Microscopic Postmortem Observations Pi Generation.................................................................................................................12 P2 Generation................................................................................................................ 21
Individual Animal Postmortem Findings Pi Generation................................................................................................................ 31 P2 Generation.............................................................................................................. 271
Pups
Fi Pups Day 25 Weaning - External and Internal Examination.................................................. 510 Day 25 Weaning - External Examination......................................................................518
FaPups
Day 21 Weaning - External and Internal Examination.................................................. 526 Day 21 Weaning - External Examination......................................................................534
BFG 003273
Huntingdon Life Sciences Reproduction Study
96-4080
Page 2 Draft Final Report
Pathology Report Incidence Summary ofMacroscopic Postmortem
Findings Preface
Appendix Y
Key to Abbreviations
LN - Lymph Nodes GL, GLS = Glands TISS = Tissue FALOP T = Fallopian Tubes
BFG 003274
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS*ALL DEATH-T.A,D;SUBSET=T
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
OBSERVATIONS INCIDENCE SUMMARY
PRINTED; 29-APR-98 PAGE: 3
STUOY NUMBER; 9640BO
___ N U M 6 E R - 0 F - A N 1 H A L S
SEX:
--MALE- -- -- --FEMALE-
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN AND KEYVORD(S) OR PHRASE
NUMBER: 30 30 30 30 30 30 30 30
** TOP OF LIST ** ADRENAL GLANDS .............................................................................. ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
AORTA .................................................................................................. ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
BRAIN .................................................................................................. ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
FEMUR .................................................................................................. ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
FEMORAL MARROW .............................................................................. ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
EPIDIDYMIDES .................................................................................. ... NUMBER EXAMINED: 30 30 30 30 0 0 0 0
ESOPHAGUS ......................................................................................... ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
EYES .................................................................................................... .. . NUMBER EXAMINED: 30 30 30 30 30 30 30 30
OPACITY
I 2 000000
HARDERIAN GLANDS .......................................................................... ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
LACRIMAL GLANDS ............................................................................ ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
HEART .................................................................................................. ... NUMBER EXAMINEO: 30 30 30 30 30 30 30 30
KIDNEYS .............................................................................................. . .. NUMBER EXAMINED: 30 30 30 30 30 30 30 30
IRREGULAR SHAPE
1 0000000
ENLARGED
0 1 000000
DILATATION
01 1 12121
CALCULUS(CALCULl)
00 1 00000
LIVER .................................................................................................. ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
NODULE(S)/MASS(ES)
0 1 00000 1
BFG 003275
LUNGS .................................................................................................. ... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
FLUID FILLED
00 00 1000
NOODLE(S)/MAS5{ES)
0000 1000
MESENTERIC LN ................................................................................
EXAMINEO: 30 30 30 30 30 30 30 30
BFG 003276
TABLE INCLUDES: SEX-ALL;GROUPsALL;WEEKSeALL OEATHT,A,D;SUBSET*T
ORGAN AND KEYWORD(S) OR PHRASE
MEDIASTINAL LN ................... OISCOLOREO
MAMMARY GLANOS ................... NODULE(S)/MASS(ES)
NERVE .......................................
NOSE/TURBINATES .................
OVIDUCTS/FALOP T ...............
OVARIES ................................... DISCOLORED-FOCUS(FOCI)
PANCREAS ................................. DISCOLORED
PITUITARY GLAND ..................
PROSTATE GLAND .................... DISCOLORED-AREA(S)
SPINAL CORD ..........................
SALIVARY GLANDS ..................
SKIN ......................................... SCAB(S)/SORE(S) HAIR ABSENT/THIN
SKELETAL MUSCLE .................
SPLEEN .....................................
STOMACH ................................... DISCOLORED-FOCUS(FOCI)
DUODENUM
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
OBSERVATIONS INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 4
STUDY NUMBER: 964080
SEX: GROUP:
-- HUM B E R - 0 F - A N I M A 1. S
----- MALE------ __ ___ -FEMALE--
1- -2- -3- -4- -1- -2- -3- -4-
NUMBER: 30 30 30 30 30 30 30 30
NUMBER EXAMINED 30 30 30 30 30 30 30 30 000 1 0000
NUMBER EXAMINEO 30 30 30 30 30 30 30 30 000000 1 1
NUMBER EXAMINEO 30 30 30 30 30 30 30 30
NUMBER EXAMINED 30 30 30 30 30 30 30 30
NUMBER EXAMINED 0 0 0 0 30 30 30 30
NUMBER EXAMINED 0 0 0 0 30 30 30 30 00000001
NUMBER EXAMINED: 30 30 30 30 30 30 30 30 0000 1 000
NUMBER EXAMINED: 30 30 30 30 30 30 30 30
NUMBER EXAMINED: 30 30 30 30 0 0 0 0 000 1 0000
NUMBER EXAMINED 30 30 30 30 30 30 30 30
NUMBER EXAMINED 30 30 30 30 30 30 30 30
NUMBER EXAMINED 30 30 30 30 30 30 30 30 I 000 0000 0000 00 I 0
NUMBER EXAMINED 30 30 30 30 30 30 30 30
NUMBER EXAMINED 30 30 30 30 30 30 30 30
NUMBER EXAMINED 30 30 30 30 30 30 30 30 0000 00 1 1
NUMBER EXAMINED: 30 30 30 30 30 30 30 30
TABLE INCLUDES: SEXsALL;GROUP=ALL;WEEKS=ALL DEATHT,A.O;SUBSET=T
ORGAN AND KEYWORO(S) OR PHRASE
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
OBSERVATIONS INCIDENCE SUMMARY
PRINTED: 29-APR-9B PAGE: 5
STUDY NUMBER: 964030
___ N U M 8 E R - 0 F - A N I M A L S
SEX:
-- HALE-- -- -- -FEMALE-
GROUP: -1- -2- -3- -4- -I- -2- -3- -4-
NUMBER: 30 30 30 30 30 30 30 30 -a- - s -
JEJUNUM ............................................................
30 30 30 30 30 30 30 30
ILEUM ................................................................ ....................................... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
CECUM ................................................................ ....................................... NUMBER EXAMINED: 30 30 30 30 30 30 30 30 COLON ................................................................ ....................................... NUMBER EXAMINED: 30 30 30 30 30 30 30 30 LOW COLON/RECTUH ....................................... ....................................... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
SEMINAL VESICLES ....................................... ....................................... NUMBER EXAMINED: 30 30 30 30 0 0 0 0
SMALL
0 1 000000
TESTES .............................................................. ....................................... NUMBER EXAMINED: 30 30 30 30 0 0 0 0
ENLARGED
0l 01 0000
SMALL
00 100000
THYROID GLAND .............................................. ....................................... NUM8ER EXAMINED: 30 30 30 30 30 30 30 30
PARATHYROID GLS .......................................... ....................................... NUM8ER EXAMINED: 30 30 30 30 30 30 30 30
THYMUS .............................................................. DISCOLORED
30 30 30 30 30 30 30 30 1 0002 0 00
TONGUE .............................................................. ....................................... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
GINGIVA ...........................................................
30 30 30 30 30 30 30 30
TRACHEA ........................................................... ....................................... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
FLUID
0000 1000
BFG 003277
LARYNX .............................................................. ....................................... NUMBER EXAMINED: 30 30 30 30 30 30 30 30
URINARY BLADDER .......................................... DISTENDED
CALCULUS(CALCULI)
30 30 30 30 30 30 30 30 0 1 00000 0 00 I 000 00
TABLE INCLUDES: SEX=ALL;GROUP=ALL;UEEKS=ALL DEATH=T,A,D;SUB$ETT
ORGAN AND KEYWORD(S) OR PHRASE
*** PATH/TOX SYSTEH OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS OBSERVATIONS INCIDENCE SUMMARY
PRINTED: 29-APR-9B PAGE: 6
STUDY NUMBER: 9640BO
___ N U M B E R - 0 F - A N I M A l S
SEX:
--MALE ---- ---- FEMALE-
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
NUMBER: 30 30 30 30 30 30 30 30 ts -
UTERUS ....................................................... IMPLANT SCARS - PRESENT IMPLANT SCARS - NOT PRESENT
IMPLANT SITES NOT NOTED
0 0 0 0 30 30 30 30 0 0 0 0 27 27 22 27 0 000 3382
0 000 000 1
VAGINA ....................................................... .............................................. NUMBER EXAMINED: 0 0 0 0 30 30 30 30
ZYMBAL'S GLANDS ................................... .............................................. NUMBER EXAMINED: 30 30 30 30 30 30 30 30
ADIPOSE TISSUE ..................................... .............................................. NUMBER EXAMINED: 30 30 30 30 30 30 30 30
NODULE(S)/MAS S{E S)
0 l 0 0 000 0
EXTREMITY ................................................ .............................................. NUMBER EXAMINEO: 30 30 30 30 30 30 30 30
SWOLLEN
0 1 00 0000
HAIR ABSENT/THIN
0 l00001 0
EARS ........................................................... .............................................. NUMBER EXAMINED: 30 30 30 30 30 30 30 30
SWOLLEN
001 1 201 2
DISCOLORED
000 1 201 1
URETHRA .................................................... .............................................. NUMBER EXAMINED: 30 30 30 30 30 30 30 30 ** END OF LIST **
BFG 003278
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TUO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
OBSERVATIONS INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 7
STUDY NUMBER: 964O60A
TABLE INCLUDES: SEX-ALL;GROUP-ALL;UEEKS-ALL
DEATH-ALL;SU8SET-T
-- NUMB E R -0 F -AN I MALS
SEX:
--MALE -- -
--FEMALE--
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
TEDTM
ORGAN AND KEYWORD(S) OR PHRASE
NUMBER: 30 30 30 30 30 29
----------------------------------------------- --------------- - S -
-S-
-a-
-a-
-a -
-a-
** TOP OF LIST ** ADRENAL GLANDS .............................................................................. ... NUMBER EXAMINEO: 30 30 30 30 30 29
30 30
*a -
30 30
AORTA .......................................................................................................................................................................................
30 30 30 30 30 29 30 30
BRAIN NUMBER EXAMINEO: 30 30 30 30 30 29 30 30................................................................................................................................................................................... ...
FEMUR NUMBER EXAMINED: 30 30 30 30 30 29 30 30....................................................................................................................................................................................... ...
FEMORAL MARROW NUMBER EXAMINED: 30 30 30 30 30 29 30 30................................................................................................................................................. ...
EPIDIDYMIDES NUMBER EXAMINEO: 30 30 30 30 0 0 0 0.......................................................................................................................................................... ...
SMALL
1 00I 0000
ESOPHAGUS ......................................................................................... ... NUMBER EXAMINEO: 30 30 30 30 30 29 30 30
EYES .................................................................................................... ... NUMBER EXAMINEO: 30 30 30 30 30 29 30 30
OPACITY
00000 0 0 1
HARDERIAN GLANDS NUMBER EXAMINEO: 30 30 30 30 30 29 30 30.......................................................................................................................................... ...
LACRIMAL GLANOS NUMBER EXAMINEO: 30 30 30 30 30 29 30 30............................................................................................................................................. ...
HEART NUMBER EXAMINED: 30 30 30 30 30 29 30 30....................................................................................................................................................................................... ...
KIDNEYS .............................................................................................................................................................................. DILATATION
NOT EVIDENT DISCOLOREO-FOCUS(FOCI)
30 30 30 30 30 29 30 30 2 1000 I 1 1 1 0000000
0000 00 0 I
LIVER .................................................................................................. ... NUMBER EXAMINEO: 30 30 30 30 30 29 30 30
DISCOLORED-FQCUS(FOCI)
0 I10 0001
BFG 003279
LUNGS ..................................................................................................
30 30 30 30 30 29 30 30
MESENTERIC LN ................................................................................ ... NUMBER EXAMINEO: 30 30 30 30 30 29 30 30
MEDIASTINAL LN .............................................................................. ... NUMBER EXAMINED: 30 30 30 30 30 29 30 30
MAMMARY GLANDS .............................................................................. ... NUMBER EXAHINED: 30 30 30 30 30 29 30 30
TABLE INCLUDES:
SEX-ALL;GROUP=ALL;WEEKS=ALL DEATH-ALL; SUBSETS
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS OBSERVATIONS INCIDENCE SUMMARY
PRINTED: 29-APR-96 PAGE: B
STUDY NUMBER: 964080A
--- N U M B E R - 0 F - A N I M A L S
SEX:
--MALE -- -- -- -FEMALE-
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN AND KEYWORD(S) OR PHRASE
NUMBER: 30 30 30 30 30 29 30 30
- II *
--a-
--a--
NERVE ........................................................................ NOSE/TURBINATES .............................................................................................. OVIDUCTS/FALOP T .......................................................................................... OVARIES ............................................................................................................................... PANCREAS ........................................................................................................................... PITUITARY GLAND ..................................................
ENLARGED PROSTATE GLAND .................................................... SPINAL CORD ........................................................... SALIVARY GLANDS .................................................. SKIN ..........................................................................
HAIR ABSENT/THIN SKELETAL MUSCLE .............................................................................................. SPLEEN .................................................................................................................................. STOMACH ............................................................................................................................... DUODENUM .......................................................................................................................... JEJUNUM ............................................................................................................................... ILEUM ........................................................................ CECUM ........................................................................ COLON ........................................................................
................. NUMBER EXAMINED: 30 30 30 30 30 29 30 30 ................. NUMBER EXAMINEO: 30 30 30 30 30 29 30 30 ......... NUMBER EXAMINEO: 0 0 0 0 30 29 30 30 ......... NUMBER EXAMINEO: 0 0 0 0 30 29 30 30 ......... NUMBER EXAMINED: 30 30 30 30 30 29 30 30 ................. NUMBER EXAMINEO: 30 30 30 30 30 29 30 30
0 0 00 000 1 ......... NUMBER EXAMINEO: 30 30 30 30 0 0 0 0 ......... NUMBER EXAMINED: 30 30 30 30 30 29 30 30 ......... NUMBER EXAMINEO: 30 30 30 30 30 29 30 30 ................. NUMBER EXAMINED: 30 30 30 30 30 29 30 30
0000 1020 ................. NUMBER EXAMINED: 30 30 30 30 30 29 30 30 ................. NUMBER EXAMINED: 30 30 30 30 30 29 30 30 ................. NUMBER EXAMINED: 30 30 30 30 30 29 30 30 ................. NUMBER EXAMINED: 30 30 30 30 30 29 30 30 ................. NUMBER EXAMINEO: 30 30 30 30 30 29 30 30 ......... NUMBER EXAMINED: 30 30 30 30 30 29 30 30 ......... NUMBER EXAMINED: 30 30 30 30 30 29 30 30 ......... NUMBER EXAMINED: 30 30 30 30 30 29 30 30
BFG 003280
LOW COLON/RECTUM ................................................
......... NUMBER EXAMINED: 30 30 30 30 30 29 30 30
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
OBSERVATIONS INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 9
STUDY NUMBER: 964060A
TABLE INCLUDES: SEX-ALL;GROUP*ALL;WEEKS-ALL DEATH-ALL;SUBSET-T
ORGAN AND KEYWORD(S) OR PHRASE
NUMBER-0 F-AN I MALS
SEX:
--MALE-- -- -- --FEMALE-
GROUP: -I- -2- -3- -4- -1- -2- -3- -4-
NUMBER: 30 30 30 30 30 29 30 30 -- tt -- -as -
SEMINAL VESICLES .................................................. ............................ NUMBER EXAMINED: 30 30 30 30 0 0 0 0
SMALL
1 000 0000
TESTES ........................................................................ ............................ NUMBER EXAMINEO: 30 30 30 30 0 0 0 0
SMALL
1 01 1 0000
ENLARGED
0 00 1 0000
SOFT
001 0 0000
THYROID GLAND ........................................................ ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
PARATHYROID GLS .................................................... ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
THYMUS ........................................................................ ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
TONGUE ........................................................................ ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
TRACHEA ...................................................................... ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
LARYNX ........................................................................ ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
URINARY BLAODER .................................................... ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
UTERUS ........................................................................ ............................ NUMBER EXAMINED: 0 0 0 0 30 29 30 30
IMPLANT SCARS - PRESENT
0 0 0 0 25 24 27 27
IMPLANT SCARS - NOT PRESENT
0000 5 533
VAGINA ........................................................................ ............................ NUMBER EXAMINED: 0 0 0 0 30 29 30 30 ZYMBAL'S GLANDS .................................................... ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
BFG 003281
LYMPH NODE ............................................................... ENLARGED
EXAMINED: 30 30 30 30 30 29 30 30 1 0000000
ADIPOSE TISSUE ...................................................... ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
NODULE(S)/MASS(ES)
000I 0 1 00
EXTREMITY ................................................................. ............................ NUMBER EXAMINED: 30 30 30 30 30 29 30 30
HAIR ABSENT
0000 0010
** CONTINUED ON NEXT PAGE **
BFG 003282
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* * * * *PATH/TOX SYSTEM OUTPUT
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
OBSERVATIONS INCIDENCE SUMMARY
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PRINTED: 29-APR-98 PAGE: 10
STUDY NUMBER: 964080A
Huntingdon Life Sciences Reproduction Study
96-4080
Page 11 Draft Final Report
Pathology Report Expanded Incidence Summary of Microscopic
Postmortem Findings Preface
Appendix Y
Key to Abbreviations
1> - Minimal 2> -- Slight 3 > = Moderate 4> = Moderately Severe 5 > = Severe TL> = Total P> = Present U/ - Unilateral B/ = Bilateral FALOP T = Fallopian Tubes
BFG 003283
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHIORIOE COMBINEO INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS MICROSCOPIC FINDINGS -- EXPANDED INCIDENCE SUMMARY
PRINTEO: 29-APR-98 PAGE: 12
STUDY NUMBER: 964060
TABLE INCLUDES: SEX-ALL;GROUP-ALL;SCREEN-ALL;WEEKS-ALL DEATH-T,A.D;FIND-ALL;SU6SET-T
-- NUMBER-OF-ANIMALS-AFFECTED --
SEX: ------------MALE------------ ---------- FEMALE GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 30 30 30
-- St --
** TOP OF LIST **
TRACHEA ..................................................................................................... NUMBER EXAMINED: 30 0 0 30 30 0 0 30
--MUCOSA: MUCOSAL 6LAN0S-DILATED
1> 2 0 0 0 0 0 0 0
TL> 2 0 0 0 0 0 0 0
LUNGS ......................................................................................................... NUMBER EXAMINED: 30 0 0 30 29 0 0 30
--CONGESTION
2> 1 0 0 0 0 0 0 0
Tl> 1 0 0 0 0 0 0 0
--PULMONARY VESSELS: MINERAL DEPOSIT(S)
1> 2 0 0 1 4 0 0 2 TL> 2 0 0 I 4 0 0 2
--LYMPHOID CELL INFILTRATE(S)/AGGREGATE(S)
1> 3 0 0 0 0 0 0 0 TL> 3 0 0 0 0 0 0 0
-- INTERSTITIUM: MINERAL DEPOSIT(S)/OSSEOUS METAPLASIA
1> 1 0 0 0 0 0 0 0 TL> 1 0 0 0 0 0 0 0
--PERIVASCULAR: EDEMA
1> 0 0 0 0 3 0 0 0 TL> 0 0 0 0 3 0 0 0
--HEMORRHAGE ALVEOLAR
2> 0 0 0 0 1 0 0 0
3> 0 0 0 0 1 0 0 0 TL> 0 0 0 0 2 0 0 0
--PERIBRONCHIAL: LYMPHOCYTIC HYPERPLASIA
2> 0 0 0 0 3 0 0 0 TL> 0 0 0 0 3 0 0 0
--PNEUMONITIS INTERSTITIAL SUBACUTE
2> 0 0 0 0 1 0 0 0 TL> 0 0 0 0 1 0 0 0
BFG 003284
--PERIVASCULAR/PERIBRONCHIAL LYMPHOID CELLS
l> 0 0 0 0 0 0 0 1 TL> 0 0 0 0 0 0 0 1
NOSE/TURBINATES ................................................................................... NUMBER EXAMINED: 0 0 0 0 0 0 0 0
NOSE/TURB SEC 1 ................................................................................... NUMBER EXAMINED: 30 0 0 30 30 0 0 30
--VOMORONASAL ORGAN: FREE ERYTHROCYTES
1> 3 0 0 0 1 0 0 2
TL> 3 0 0 0 1 0 0 2
CONTINUED ON NEXT PAGE
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS -- EXPANDED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 13
STUDY NUMBER: 9640B0
TABLE INCLUDES: SEX-ALL;GROUP=ALL;SCREEN-ALL;WEEKS-ALL DEATH-T,A,D;FIND-ALL;SUBSET-T
-- NUMB E R-0F-AN I MA LS
SEX:
----- MALE---
-- --FEMALE-
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED ** FROM PREVIOUS PAGE **
NUMBER: 30 30 30 30 30 30 30 30 -a-
"="
NOSE/TURB SEC 1 ................................................................................... NUMBER EXAMINEO: 30 0 0 30 30 0 0 30
--NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
1> 1 0 0 I 0 0 0 0
2> 1 0 0 0 0 0 0 0
TL> 2 0 0 1 0 0 0 0
--NASAL MUCOSA (RESPIRATORY): ACUTE/SUBACUTE INFLAMMATION
1> 1 0 0 0 0 0 0 0 Tl> 1 0 0 0 0 0 0 0
--ODONTOPATHY
1> 0 0 0 2 0 0 0 1 2> 1 0 0 0 0 0 0 0 TL> 1 0 0 2 0 0 0 1
--NASAL MUCOSA (RESPIRATORY): GOBLET CELL HYPERTROPHY/HYPERPLASIA 1> 0 0 0 0 0 0 0 3 2> 0 0 0 1 0 0 0 0
TL> 0 0 0 1 0 0 0 3
-NASOLACRIMAL DUCT(S): EOSINOPHILIC MATERIAL
1> 0 0 0 2 0 0 0 I TL> 0 0 0 2 0 0 0 1
--NASAL LUMEN: FREE ERYTHROCYTES
2> 0 0 0 0 1 0 0 0 TL> 0 0 0 0 1 0 0 0
--NASAL LUMEN: EXUDATE
1> 0 0 0 0 1 0 0 1 TL> 0 0 0 0 1 0 0 1
--NASAL MUCOSA (JUNCTION OF THE RESPIRATORY/OLFACTORY MUCOSA)
000000 0 1
GLANDS OILATEO
TL> 0 0 0 0 0 0 0 1
--NASOLACRIMAL OUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
2> 0 0 0 0 0 0 0 1 TL> 0 0 0 0 0 0 0 l
BFG 003285
-NASOLACRIMAL DUCT: EXUDATE
l> 0 0 0 0 0 0 0 1 TL> 0 0 0 0 0 0 0 1
NOSE/TURB SEC 2 .................................................................................. NUMBER EXAMINED: 30 0 0 30 30 0 0 30
--NASAL LUMEN: FREE ERYTHROCYTES
1> 2 0 0 1 0 0 0 0
3> 0 0 0 0 1 0 0 0
TL> 2 0 0 1 1 0 0 0
** CONTINUED ON NEXT PAGE **
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS --- EXPANDED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 14
STUOY NUMBER: 964060
TABLE INCLUDES: SEX-ALL;GROUP=ALL;SCREEN-ALL;WEEKS-ALL DEATH-T,A,D;FIND-ALL;SUBSET*T
-- NUMBER-0F-AN1MALS-AFFECTED --
SEX: -............ MALE............ ................... FEMALE............ GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 30 30 30
** FROM PREVIOUS PAGE **
NOSE/TURB SEC 2 ............................................................................ ... NUMBER EXAMINEO: 30 0 0 30 30 0 0 30
-- NASOLACRIMAL DUCT(S): INFLAMMATORY CELLS/CELL DEBRIS
1> 2 0 0 4 3 0 0 2
TL> 2 0 0 4 3 0 0 2
-- NASOLACRIMAL DUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
1> 1 0 0 0 0 0 0 3 2 1 0 0 1 0 0 0 3
3> 2 0 0 0 1 0 0 0 TL> 4 0 0 1 1 0 0 6
--VOMORONASAL ORGAN: EOSINOPHILIC MATERIAL
1> 3 0 0 0 2 0 0 2
2> 1 0 0 0 0 0 0 0 TL> 4 0 0 0 2 0 0 2
--ODONTOPATHY
1> 0 0 0 2 0 0 0 1 2> 1 0 0 1 1 0 0 1
3> 2 0 0 1 0 0 0 0 TL> 3 0 0 4 1 0 0 2
-- VOMERONASAL ORGAN: FREE ERYTHROCYTES
!> 1 0 0 0 3 0 0 3 TL> 1 0 0 0 3 0 0 3
-- NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
1> 3 0 0 3 2 0 0 0 2> 2 0 0 0 3 0 0 0
TL 5 0 0 3 5 0 0 0
--NASOLACRIMAL DUCT: EXUDATE
I> 0 0 0 0 0 0 0 1
2> 0 0 0 0 1 0 0 I TL> 0 0 0 0 1 0 0 2
BFG 003286
--NASAL LUMEN: INFLAMMATORY CELLS/CELL DEBRIS
1> 0 0 0 0 0 0 0 I TL> 0 0 0 0 0 0 0 1
--VOMERONASAL ORGAN: EXUDATE
1> 0 0 0 0 0 0 0 1 TL> 0 0 0 0 0 0 0 1
NOSE/TURB SEC 3 ............................................................................ ... NUMBER EXAMINEO: 30 0 0 30 30 0 0 30
--NASAL MUCOSA (RESPIRATORY): EPITHELIUM-1NTRACYTOPLASMIC
l> 1 0 0 1 4 0 0 0
EOSINOPHLIC MATERIAL
TL> 1 0 0 1 4 0 0 0
** CONTINUED ON NEXT PAGE *
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS -- EXPANDED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 15
STUDY NUMBER: 9640B0
TABLE INCLUDES: SEX=ALL;GROUPALL;SCREEN-ALL;WEEKS=ALL DEATH=T,A,0;FIND-ALL;SUBS ET-T
-- NUMB E R- 0 F - AN I MA LS
SEX:
----- MALE--- -- ---- FEMALE-
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 30 30 30
-a-- -*--
a
** FROM PREVIOUS PAGE **
N0SE/TUR8 SEC 3 ................................................................................... NUMBER EXAMINED: 30 0 0 30 30 0 0 30
--NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA
1> 10 0 0 2 8 0 0 5
2> 3 0 0 3 8 0 0 1
TL> 13 0 0 S 16 0 0 6
--NASOLACRIMAL DUCT(S): MUCOSA-SUBACUTE {CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
1> 3 0 0 0 0 0 0 0
2> 2 0 0 0 0 0 0 0 TL> 5 0 0 0 0 0 0 0
--NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASM 1C EOSINOPHILIC MATERIAL
1> 7 0 0 12 13 0 0 6
2> 4 0 0 1 0 0 0 0 4> 0 0 0 1 0 0 0 0 TL> 11 0 0 14 13 0 0 6
--NASAL MUCOSA (OLFACTORY): EPITHELIUM DEGENERATION
1> 1 0 0 0 0 0 0 0 TL> 1 0 0 0 0 0 0 0
--NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
1> 0 0 0 2 2 0 0 0
2> 0 0 0 0 1 0 0 0 TL> 0 0 0 2 3 0 0 0
--NASAL LUMEN: FREE ERYTHROCYTES
1> 0 0 0 2 0 0 0 1 2> 0 0 0 0 1 0 0 0
3> 0 0 0 0 1 0 0 0
TL> 0 0 0 2 2 0 0 1
--NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL
1> 0 0 0 1
1000
TL> 0 0 0 1 1 0 0 0
--NASAL MUCOSA (RESPIRATORY): BASOPHILIC MATERIAL
1> 1 0 0 0 0 0 0 0 TL> 1 0 0 0 0 0 0 0
BFG 003287
--NASAL LUMEN: INFLAMMATORY CELLS/CELL DEBRIS
1> 0 0 0 0 0 0 0 1 TL> 0 0 0 0 0 0 0 1
PRINTED: 29-APR-98 PAGE: 16
STUDY NUMBER: 964080
EXPANDEO INCIDENCE SUMMARY
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS--
VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION
UJ (*) _J I <
oo>* -- Mmin oo so
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O OJ (SI IsxOO 9)0 0 OO (SI O (si
LUi mI
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ui/ji oa
* * * PATH/TOX SYSTEM OUTPUT * * *
MICROSCOPIC FINDINGS
uj x
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BFG 003288
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS -- EXPANOEO INCIDENCE SUMMARY
PRINTEO; 29-APR-98 PAGE: 17
STUDY NUMBER: 964080
TABLE INCLUDES:
SEX-ALL;GROUP-ALL;SCREEN-ALL;WEEKS-ALL DEATH-T.A,D;FIND-ALL;SUBSET-T
-- NUM8E R -0 F - AN I MA L S
SEX:
----- MALE---
---FEMALE-
GROUP: -1- -2- -3- -4- -I- -2- -3- -4-
ORGAN/TISSUE EXAMINED --------------- -------------------------------------------- - - -
NUMBER: 30 30 30 30 30 30 30 30 -S - - S - -3- -- a - - 3 - - 3 - -3- - = -
** FROM PREVIOUS PAGE **
LIVER ....................................................................................................... . NUMBER EXAMINED: 30 30 30 30 30 30 30 30
--HEPATOCYTES: BASOPHILIC FOCUS
1> 0 0 0 l 0 0 0 0
TL> 0 0 0 l 0 0 0 0
--HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
1> 0 0 15 30 0 2 26 30 TL> 0 0 15 30 0 2 26 30
--HEPATOCYTES: ACIDOPHILIC FOCUS
1> 0 0 0 1 0 0 0 0 TL> 0 0 0 1 0 0 0 0
-PELIOSIS HEPATIS
1> 0 0 2 0 0 0 0 0 TL> 0 0 2 0 0 0 0 0
--MICROGRANULOMA
1> 0 0 0 0 0 0 1 0 TL 0 0 0 0 0 0 I 0
KIDNEYS .................................................................................................. . NUMBER EXAMINED: 30 0 0 30 30 0 0 30
--U: PYELITIS.SUBACUTE
1> 2 0 0 1 0 0 0 1
TL> 2 0 0 1 0 0 0 1
--CORTEX: INFILTRATES.SUBACUTE
1> 5 0 0 5 4 0 0 4 TL> 5 0 0 5 4 0 0 4
--DILATED TUBULES
1> l 0 0 1 1 0 0 1 TL> 1 0 0 1 1 0 0 1
-MEDULLA: CYST
1> I a 0 0 1 0 0 0 TL> 1 0 0 0 1 0 0 0
-- INTERSTITIAL NEPHRITIS SUBACUTE
I> 0 0 0 2 1 0 0 0 TL> 0 0 0 2 I 0 0 0
BFG 003289
-- PELVIS DILATED ** CONTINUED ON NEXT PAGE **
l> 0 0 0 1 1 0 0 1 Z> 0 0 0 0 0 0 0 1 3> 0 0 0 1 0 0 0 0 4> 0 0 0 0 2 0 0 0 TL> 0 0 0 2 3 0 0 2
* * * PATH/TOX SYSTEM OUTPUT * * *
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
--REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
MICROSCOPIC FINDINGS
EXPANOEO INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 18
STUDY NUMBER: 964080
i -- <n n
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i m _j
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er, --j a n n -i
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AAA
csi ro .
O CSI__I O -- C\J n-i --
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--1 1 o
a. o
-oioz.
-ALVEOLAR LUMENS: CORPORA AMYLACIA/MIWERALIZED GRANULES
Mm
BFG 003290
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS --- EXPANDED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 19
STUDY NUMBER: 964080
TABLE INCLUDES: SEX*ALL;GROUPAlL;SCREEN=ALL;WEEKS-ALL DEATH=T,A,D;FI NO-ALL;SUBSET-T
--- N U M B E R - 0 F - A N I M A L S
SEX:
--MALE-- -- -- -FEMALE-
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 30 30 30
as-
COAGULATING GL ............................................................................ ___ NUMBER EXAMINED: 30 0 0 30 0 0 0 0
OVARIES ........................................................................................... .... NUMBER EXAMINED: 0 0 0 0 30 0 0 30
0V1DUCTS/FAL0P T ........................................................................
0 0 0 0 30 0 0 30
UTERUS .............................................................................................. .... NUMBER EXAMINED: 0 0 0 0 30 0 0 30
--ENDOMETRIUM: BROWN PIGMENT
1> 0 0 0 0 10 0 0 4
2> 0 0 0 0 1 0 0 0
TL> 0 0 0 0 11 0 0 4
--ENOOMETRIUM: HEMORRHAGE(S)
2> 0 0 0 0 1 0 0 0 TL> 0 0 0 0 I 0 0 0
--MYOMETRIUM: BROWN PIGMENT
1> 0 0 0 0 6 0 0 9
2> 0 0 0 0 6 0 0 12 3> 0 0 0 0 1 0 0 1
TL> 0 0 0 0 13 0 0 22
--ENDOMETRIUM: INFILTRATES SUBACUTE
I> 0 0 0 0 1 0 0 0 TL> 0 0 0 0 1 0 0 0
--LUMEN: OILATED
1> 0 0 0 0 0 0 0 2 2> 0 0 0 0 0 0 0 2 TL> 0 0 0 0 0 0 0 4
BFG 003291
--ENDOMETRIUM: GLANDS 01LATEO/CYSTIC DILATION
I> 0 0 0 0 0 0 0 2 TL> 0 0 0 0 0 0 0 2
VAGINA ............................................................................................. .... NUMBER EXAMINED: 0 0 0 0 30 0 0 30
--MUOCSA: HYERPKERAT0S1S (CORNIFIED)
I> 0 0 0 0 0 0 0 1
TL> 0 0 0 0 0 0 0 1
PITUITARY GLANO .......................................................................... ... . NUMBER EXAMINED: 30 0 0 30 30 0 0 30
-- PARS INTERMEDIA: CYST(S)
1> 0 0 0 0 1 0 0 0
2> 1 0 0 0 0 0 0 0
TL> 1 0 0 0 1 0 0 0
CONTINUED ON NEXT PAGE **
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHL0RI0E COMBINEO INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUOY IN CO RATS MICROSCOPIC FINDINGS -- EXPANOED INCIDENCE SUMMARY
PRINTEO: 29-APR-98 PAGE: 20
STUOY NUMBER: 964060
TABLE INCLUDES: SEX*ALL;GROUPALL;SCREENALL;WEEKS=ALL
OEATH=T,A,D;FIND-ALL;SUBSET*!
-- NUMBE R- 0 F-AN I MALS
SEX:
----- MALE -- -- ---FEMALE-
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 ~ - s--
** FROM PREVIOUS PAGE **
PITUITARY GLAND ................................................................................... NUMBER EXAMINED: 30 0 0
-- PARS 0ISTAL1S: CYSTS
I> 2 0 0
TL> 2 0 0
30 30 30 30 --*-- -- ---
30 30 0 0 3 100 3 100
30
30 1 1
MAMMARY GLANDS ..................................................................................... NUMBER EXAMINED: 28 0 0 25 30 0 0 30
--ADENOMA
P> 0 0 0 0 0 0 0 I
TL> 0 0 0 0 0 0 0 1
THYMUS ...................................................................................................... NUMBER EXAMINED: 1 0 0 0 2 0 0 0
--HEMORRHAGE(S)
1> 1 0 0 0 0 0 0 0
TL> 1 0 0 0 0 0 0 0
--CONGESTION
1> 0 0 0 0 2 0 0 0 TL> 0 0 0 0 2 0 0 0
SKIN ........................................................................................................... NUMBER EXAMINED: I 0 0 0 0 0 0 0
-- ULCERATIVE DERMATITIS
3> 1 0 0 0 0 0 0 0
TL> 1 0 0 0 0 0 0 0
MEDIASTINAL LN ..................................................................................... NUMBER EXAMINED: 0 0 0 I 0 0 0 0
--HEMORRHAGE(S)
2> 0 0 0 1 0 0 0 0
TL> 0 0 0 1 0 0 0 0
EYES ........................................................................................................... NUMBER EXAMINED: 1 0 0 0 0 0 0 0
EARS ........................................................................................................... NUMBER EXAMINED: 0 0 0 1 2 0 0 2
--SUBACUTE (CHRONIC ACT!VE)/CHRONIC INFLAMMATION
3> 0 0 0 1 2 0 0 1
4> 0 0 0 0 0 0 0 1
TL> 0 0 0 I 2 0 0 2
BFG 003292
--NECROSIS CARTILAGE
l> 0 0 0 0 2 0 0 0 3> 0 0 0 1 0 0 0 2 TL> 0 0 0 I 2 0 0 2
PANCREAS .................................................................................................. NUMBER EXAMINED: 0 0 0 0 1 0 0 0
STOMACH .................................................................................................... NUMBER EXAMINED: 0 0 0 0 0 0 0 1 ** END OF LIST *
* * * * * *PATH/TOX SYSTEM OUTPUT
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
--REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
MICROSCOPIC FINDINGS
EXPANDED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 21
STUDY NUMBER: 964080A
U1/1 Ko i
O (D .
--Zt
iii ^ii
OJ fO II
-- rt II
(/> i --tt--st lII okb <
'--> b LiJ
<z I okzU <oDi t ** b<as-
I --I
O O --C
o ooo o o o o oo
a o o 09
O OOO
o
oo oo
--
tu --:
o o -- ~
a. z --
--
oo oo
-- to
o o o o --H --
at
oo
oo o
i tsj (*5 r,N O O
-ACUTE/SUBACUTE INFLAMMATION
BFG 003293
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS MICROSCOPIC FINDINGS --- EXPANDED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 22
STUDY NUMBER: 964080A
TABLE INCLUDES:
SEX=ALL;GROUPALL;SCREEN-ALL;WEEKS-ALL DEATH=ALL;F1ND*ALL;SUBSET*T
NUMBER-0F -AN I MALS
SEX:
--MALE ---- ---- FEMALE-
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
1 u>o
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30
30 29 30 30
** FROM PREVIOUS PAGE **
LIVER ........................................................................................... ............. NUMBER EXAMINED: 30 30 30 30 30 29 30 30
--BASOPHILIC FOCUS
1> 0 0 0 6 0 0 1 11
TL> 0 0 0 8 0 0 1 11
--CLEAR CELL FOCUS
1> 0 0 0 5 0 0 0 0 TL> 0 0 0 5 0 0 0 0
--BILE DUCT/BILIARY EPITHELIUM: HYPERPLASIA
1> 0 0 0 1 0 0 0 0 TL> 0 0 0 1 0 0 0 0
--HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
1> 0 0 19 30 0 6 30 30 TL> 0 0 19 30 0 6 30 30
--NECROSIS.COAGULATION
1> 0 0 0 0 0 1 0 0 1> 0 0 0 0 0 0 2 0
TL> 0 0 0 0 0 1 2 0
-- PEL IOS IS HEPATIS
1> 0 0 1 0 0 0 0 0 TL> 0 0 1 0 0 0 0 0
-- EXTRA MEDULLARY HEMATOPOIESIS
1> 0 0 0 0 0 0 2 0 TL> 0 0 0 0 0 0 2 0
--ANGIECTASIS
2> 0 0 0 0 0 0 2 0 TL> 0 0 0 0 0 0 2 0
KIDNEYS ....................................................................................... ........... NUMBER EXAMINEO: 30 0 0 30 30 0 0 30
--CORTEX: INFILTRATES SUBACUTE
1> 4 0 0 4 1 0 0 4
TL> 4 0 0 4 1 0 0 4
BFG 003294
-- TUBULES DILATED
1> 2 0 0 2 0 0 0 1 TL> 2 0 0 2 0 0 0 1
--PELVIS: INFLAMMATION SUBACUTE ** CONTINUED ON NEXT PAGE **
1> 0 0 0 0 0 0 0 1
2> 1 0 0 0 0 0 0 0 3> 1 0 0 0 0 0 0 0 TL> 2 0 0 0 0 0 0 1
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS -- EXPANOED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 23
STUOY NUMBER: 964060A
TABLE INCLUDES:
SEXALL;GROUPALL;SCREENALL;WEEKSALL DEATH=ALL;FINOALL;SUBSETT
NUMBE R- 0 F- AN I MALS
SEX:
----- MALE-- -- ---FEMALE--
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 29 30 30
** FROM PREVIOUS PAGE ** KIDNEYS ............................................................................
--PELVIS: EPITHELIAL HYPERPLASIA
... NUMBER EXAMINED: 30 0 0 30 30 0 0 30 1> 1 0 0 0 0 0 0 1
2> 1 0 0 0 0 0 0 0 TL> 2 0 0 0 0 0 0 1
--PELVIS: MINERALIZED GRANULES
1> 2 0 0 0 0 0 0 0 TL 2 0 0 0 0 0 0 0
--PELVIS: DILATED
1> 1 0 0 1 0 0 0 3 TL> 1 0 0 i 0 0 0 3
--PYELONEPHRITIS
3> 1 0 0 0 0 0 0 0 Tl> 1 0 0 0 0 0 0 0
--MINERALIZED GRANULES
I> 0 0 0 0 1 0 0 4 2> 0 0 0 0 0 0 0 1 TL> 0 0 0 0 1 0 0 5
--PELVIS: FREE ERYTHROCYTES
1> 0 0 0 3 4 0 0 1 TL> 0 0 0 3 4 0 0 1
TESTES .............................................................................. --TUBULAR DEGENERATION
... NUMBER EXAMINED: 29 0 0 30 0 0 0 0 2> 1 0 0 0 0 0 0 0
3> 1 0 0 1 0 0 0 0 S> I 0 0 1 0 0 0 0 TL> 3 0 0 2 0 0 0 0
EPIDIDYMIDES ................................................................. --ASPERMIA
. .. NUMBER EXAMINED: 29 0 0 30 0 0 0 0 5> 1 0 0 1 0 0 0 0
TL 1 0 0 1 0 0 0 0
BFG 003295
--HYPOSPERMIA
3> 1 0 0 0 0 0 0 0 TL> 1 0 0 0 0 0 0 0
PROSTATE GLAND ............................................................. --EDEMA
** CONTINUED ON NEXT PAGE **
. . . NUM8ER EXAMINED: 30 0 0 30 0 0 0 0
1> 2 0 0 1 0 0 0 0 TL> 2 0 0 1 0 0 0 0
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS -- EXPANDED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 24
STUDY NUMBER: 964080A
TABLE INCLUDES:
SX"ALL;GROUP=ALL;SCREEN"ALL;WEEKS"ALL DEATH=ALL;FIND=ALL;SUBSET=T
NUMBE R- 0 F -AN IMA LS
SEX:
--MALE -- -- -- --FEMALE-
GROUP: -1- -2- -3- -4- -L- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 29 30 30
** FROM PREVIOUS PAGE **
PROSTATE GLAND ............................................................................ ... NUMBER EXAMINED: 30 0 0 30 0 0 0 0
--ACUTE/SUBACUTE INFLAMMATION
1> 4 0 0 2 0 0 0 0
2> 5 0 0 0 0 0 0 0
TL> 9 0 0 2 0 0 0 0
--ALVEOLAR LUMENS: CORPORA AMYLACIA/HINERALIZED GRANULES
1> 4 0 0 4 0 0 0 0 TL> 4 0 0 4 0 0 0 0
--ALVEOLAR LUMENS: EXUOATE
1> 1 0 0 0 0 0 0 0 TL> 1 0 0 0 0 0 0 0
SEMINAL VESICLES ........................................................................ .. . NUMBER EXAMINED: 30 0 0 30 0 0 0 0
--INFLAMMATION, SUBACUTE
2> 1 0 0 0 0 0 0 0
TL> 1 0 0 0 0 0 0 0
COAGULATING GL ............................................................................ . . . NUMBER EXAMINEO: 30 0 0 30 0 0 0 0
OVARIES ........................................................................................... . . . NUMBER EXAMINED: 0 0 0 0 30 0 0 30
OVIDUCTS/FALOP T ........................................................................ . . . NUMBER EXAMINED: 0 0 0 0 30 0 0 30
UTERUS ................................................................................................ . . . NUMBER EXAMINED: 0 0 0 0 30 0 0 30
--LUMEN: OILATEO
1> 0 0 0 0 4 0 0 5
2> 0 0 0 0 2 0 0 3
TL> 0 0 0 0 6 0 0 8
-- MYOMETRIUM: BROWN PIGMENT
1> 0 0 0 0 12 0 0 6
2> 0 0 0 0 7 0 0 7 TL> 0 0 0 0 19 0 0 13
BFG 003296
-- ENDOMETRIUM: BROWN PIGMENT
1> 0 0 0 0 1 0 0 12 TL> 0 0 0 0 1 0 0 12
-- ENDOMETRIUM: HYPERPLASIA
1> 0 0 0 0 0 0 0 1 TL> 0 0 0 0 0 0 0 1
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS -- EXPANDEO INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 25
STUOY NUMBER: 964080A
TABLE INCLUDES: SEX*ALL;GROUP*ALL;SCREEN=ALL;UEEKS=ALL DEATHALL;FIND-ALL;SUBSETT
--- N U M B E R - 0 F - A N I M A L S
SEX:
--MALE-- -- -- -FEMALE-'
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30
-------- ------------------------------------------------------------------------------ ------w---------------- -a- -a- -a- -a- -a-
29 30 30
-a- -a-
VAGINA ......................................................................................... --MUCOSA: HYPERKERATOSIS (CORNIFIED)
0 0 0 0 26 0 0 30 1> 0 0 0 0 3 0 0 3 2> 0 0 0 0 1 0 0 0 TL> 0 0 0 0 4 0 0 3
PITUITARY GLAND ...................................................................... ........... NUMBER EXAMINED: 30 0 0 30 30 0 0 30
-- PARS INTERMEDIA: CYST(S)
1> 1 0 0 2 0 0 0 0
TL> 1 0 0 2 0 0 0 0
--PARS D1STAL1S: CYSTS
I> 0 0 0 1 0 0 0 0 TL> 0 0 0 1 0 0 0 0
--PARS DISTALIS: FOCAL HYPERPLASIA
I> 0 0 0 0 0 0 0 1 TL> 0 0 0 0 0 0 0 1
MAMMARY GLANDS ........................................................................ ........... NUMBER EXAMINED: 26 0 0 25 29 0 0 30 NOSE/TURBINATES ...................................................................... ........... NUMBER EXAMINED: 0 0 0 0 0 0 0 0
NOSE/TURB SEC 1 ...................................................................... ........... NUMBER EXAMINED: 30 0 0 30 30 0 0 30
-- NASAL LUMEN: FREE ERYTHROCYTES
I> 2 0 0 I 0 0 0 0
TL> 2 0 0 1 0 0 0 0
--NASAL MUCOSA (RESPIRATORY): ACUTE/SU8ACUTE INFLAMMATION
1 I 0 0 I 0 0 0 0 3> 0 0 0 0 1 0 0 0
TL> 1 0 0 I 1 0 0 0
--NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
I> 0 0 0 I 0 0 0 0 2> 0 0 0 0 0 0 D 2 TL> 0 0 0 I 0 0 0 2
BFG 003297
--NASOLACRIMAL OUCT(S): EOSINOPHILIC MATERIAL
1> 0 0 0 1 0 0 0 0 TL> 0 0 0 I 0 0 0 0
--VOMERONASAL ORGAN: FREE ERYTHROCYTES ** CONTINUED ON NEXT PAGE **
1> 2 0 0 2 1 0 0 1 TL> 2 0 0 2 1 0 0 1
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUOY IN CO RATS MICROSCOPIC FINDINGS --- EXPANDED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 26
STUDY NUMBER: 964080A
TABLE INCLUDES:
SEX*ALL;GROUP*ALL;SCREENALL;WEKSALL DEATH=ALL;FIND-ALL;SUBSET-T
-- NUH BE R-0 F-AN 1 MALS
SEX:
--MALE ---- ---FEMALE-
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 """ --a - "*" --a- ~ m ~~
** FROM PREVIOUS PAGE ** NOSE/TURB SEC 1 ................................................................................... NUMBER EXAMINED: 30 0 0 30 30
--NASAL MUCOSA (RESPIRATORY): GOBLET CELL HYPERTROPHY/HYPERPLASIA 1> I 0 0 2 0
TL> 1 0 0 2 0
29 30 30 -a- --a-
0 0 30 000 000
-ODONTOPATHY
1> 1 0 0 1 1 0 0 0
TL 1
001
1000
--VOMERONASAL ORGAN: EOSINOPHILIC MATERIAL
1* 1 0 0 0 1 0 0 0 TL> 1 0 0 0 I 0 0 0
-NASOLACRIMAL DUCT: EXUDATE
2> 0 0 0 0 1 0 0 0 TL> 0 0 0 0 1 0 0 0
--NASAL LUMEN: EXUDATE
3> 0 0 0 0 I 0 0 0 TL> 0 0 0 0 1 0 0 0
--NASAL MUCOSA (VESTIBULAR): SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
1> 0 0 0 1 0 0 0 0 TL> 0 0 0 1 0 0 0 0
NOSE/TURB SEC 2 ................................................................................... NUMBER EXAMINED: 30 0 0 30 30 0 0 30
-NASAL LUMEN: FREE ERYTHROCYTES
TL> 0 0 0 0 0 0 0 0
--NASOLACRIMAL OUCT(S): INFLAMMATORY CELLS/CELL DEBRIS
1> 0 0 0 3 1 0 0 1 TL> 0 0 0 3 1 0 0 1
-NASOLACRIMAL DUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
1> 0 0 0 4 0 0 0 1 4> 0 0 0 0 I 0 0 0 5> 0 0 0 0 I 0 0 0
TL> 0 0 0 4 2 0 0 1
BFG 003298
-ODONTOPATHY
I> 2 0 0 2 1 0 0 0
2> 1 0 0 0 0 0 0 0
TL> 3
002
I00
0
-VOMERONASAL ORGAN: FREE ERYTHROCYTES ** CONTINUED ON NEXT PAGE **
1> 2 0 0 3 0 0 0 0 TL> 2 0 0 3 0 0 0 0
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBIHEO INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS --- EXPANDED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 27
STUDY NUMBER: 964080A
TABLE INCLUDES: SEX*ALL;GROUP"ALL;SCREENALL;WEEKSALL
DEATH-ALL;FINO-ALL:SUBSET-T
--- N U M B E R - 0 F - A N I H A 1L s
SEX:
----- MALE--- -- ---FEMALE-
GROUP: -1- -2- -3- -4- -I- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 29 30 30
** FROM PREVIOUS PAGE **
NOSE/TURB SEC 2 .............................................................................. ... NUMBER EXAMINED: 30 0 0 30 30 0 0 30
--NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
i> 2 0 0 2 2 0 0 2
2> 0 0 0 0 0 0 0 3
TL> 2 0 0 2 2 D 0 5
--VOMERONASAL ORGAN: EOSINOPHILIC MATERIAL
i> 3 0 0 0 1 0 0 1 TL> 3 0 Q 0 1 0 0 1
--VOMERONASAL ORGAN: EXUDATE
I> 0 0 0 0 0 0 0 1 TL> 0 0 0 0 0 0 0 1
-- NASOLACRIMAL DUCT: EXUDATE
I> 0 0 0 1 0 0 0 0 3> 0 0 0 0 1 0 0 0 4> 0 0 0 0 1 0 0 0
TL> 0 0 0 I 2 0 0 0
NOSE/TURB SEC 3 ................................................................................. NUMBER EXAMINED: 30 0 0 30 30 0 0 30
--NASAL LUMEN: FREE ERYTHROCYTES
i> I 0 0 1
000 0
2> 0 0 0 0 l 0 0 1
3> 0 0 0 1
000 0
TL> 1 0 0 2 l 0 0 I
--NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
--NASOLACRIMAL DUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
t> 8 0 0 3 7 0 0 4 TL> 8 0 0 3 7 0 0 4
1> 2 0 0 0 1 0 0 0 Z> 0 0 0 0 1 0 0 0 4> 0 0 0 0 1 0 0 0 TL> 2 0 0 0 3 0 0 0
BFG 003299
--NASOLACRIMAL OUCT: LYMPHOID HYPERPLASIA
1> 13 0 0 8 8 0 0 8
2> 0 0 0 0 2 0 0 0 3> 0 0 0 0 1 0 0 0 TL> 13 0 0 8 11 0 0 8
--NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL ** CONTINUED ON NEXT PAGE **
l> 2 0 0 1 TL> 2 0 0 1
0000 00 0 0
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS -- EXPANOED INCIDENCE SUMMARY
PRINTED: 29-APR-98 PAGE: 28
STUOY NUMBER: 964O60A
TABLE INCLUDES: SEX=ALL;GROUP"ALL;SCREEN*ALL;WEEKSALL DEATH-ALL;FIND-ALL; SUBSETS
-- N U M B E R - 0 F - A N I N A 1L S
SEX:
--MALE--
--FEMALE --
GROUP: -1- -2- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 29 30 30
--------------------------------------------------------- - - ------ - - ----------- --------------------- -s- - = - -s- - s - -= - -a- --E-- -s-
** FROM PREVIOUS PAGE **
NOSE/TURB SEC 3 ................................................................................... NUMBER EXAMINED: 30 0 0 30 30 0 0 30
--NASOLACRIMAL OUCT(S): FREE ERYTHROCYTES
1> 1 0 0 1 0 0 0 0
2> 0 0 0 0 0 0 0 1
TL> 1 0 0 1 0 0 0 1
--NASOLACRIMAL DUCT: EXUDATE
1> 0 0 0 0 1 0 0 0 3> 0 0 0 0 1 0 0 0
TL> 0 0 0 0 2 0 0 0
NOSE/TURB SEC 4 ................................................................................... --NASAL LUMEN: FREE ERYTHROCYTES
NUMBER EXAMINED: 1> 2> 3>
TL>
30
2 1 0 3
0 0 0 0
0
0 30 30 00 1 000 01 L
01 2
0 0 30 00 1 00 0 00 1 00 2
--NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
1> 18 0 0 9 11 0 0 10 2> 1 0 0 1 3 0 0 0
TL> 19 0 0 10 14 0 0 10
--NASOLACRIMAL DUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
TL> 0 0 0 0 0 0 0 0
--NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL
l> 3 0 0 6 1 0 0 3 TL> 3 0 0 6 1 0 0 3
URETHRA .................................................................................................... NUMBER EXAMINED: 3 0 0 0 0 0 0 0
-- SEMINAL COAGULUM
1> 2 0 0 0 0 0 0 0
TL> 2 0 0 0 0 0 0 0
-- INFLAMMATION. SUBACUTE
2> 1 0 0 0 0 0 0 0 TL> 1 0 0 0 0 0 0 0
BFG 003300
MESENTERIC LN ....................................................................................... NUMBER EXAMINED: 1 0 0 0 0 0 0 0
-- LYMPHOID HYPERPLASIA
2> 1 0 0 0 0 0 0 0
TL> I 0 0 0 0 0 0 0
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS MICROSCOPIC FINDINGS -- EXPANOED INCIDENCE SUMMARY
PRINTEO: Z9-APR-98 PAGE: 29
STUDY NUMBER: 964O80A
TABLE INCLUDES: SEX-ALL;GROUPAll;SCREEN-AIL;UEEKSALL
DEATH-ALL;FIND-ALL;SUBSETT
___ N U M 6 E R - 0 F - A N I M A L S
SEX:
--MALE -- -- -- --FEMALE--
GROUP: -1- -Z- -3- -4- -1- -2- -3- -4-
ORGAN/TISSUE EXAMINED
NUMBER: 30 30 30 30 30 29 30 30
PREPUT/CLIT GL ............................................................................ --INFLAMMATION. SUBACUTE
1 0 000 000 l> 1 0 0 0 0 0 0 0
TL> 1 0 0 0 0 0 0 0
SKIN .................................................................................................. ... NUMBER EXAMINEO: 0 0 0 0 1 0 0 0
EXTREMITY ....................................................................................... ... NUMBER EXAMINED: 0 0 0 0 0 0 0 1
ADIPOSE TISSUE ............................................................................ ... NUMBER EXAMINEO: 0 0 0 1 0 0 0 0
-- ECTOPIC EPIDIDYMIS
3> a 0 a I Q 0 0 0
TL> 0 0 0 I 0 0 0 0
** END OF LIST **
BFG 003301
Huntingdon Life Sciences Reproduction Study_____
96-4080
Page 30 Draft Final Report
Individual Animal Postmortem Findings Preface
Appendix Y
Key to Abbreviations
U/ B/
R,(R)
L,(L)
w
TE LN FALOP T = ASSOC = MFOC SUBA
Unilateral Bilateral Right Left With Testes Lymph Node Fallopian Tubes Associated Multifocal Subacute
Note
Unless otherwise specified in a histopathology note, the organ/tissue examined was the required (routine) section.
BFG 003302
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 31
STUOY NUMBER: 964080
ANIMAL NUMBER: 1001 OATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL 80DY WEIGHT: 458.3 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES LIVER . .
MICRO: MICRO:
N0SE/TUR8 SEC 2 MICRO:
NQSE/TURB SEC 3 MICRO:
NQSE/TUR8 SEC 4 MICRO:
HISTOPATHOLOGICAL COMMENT:
-MINIMAL. MULTI-FOCAL -MINIMAL, MULTI-FOCAL -MINIMAL. MULTI-FOCAL
HISTOPATHOLOGICAL COMMENT:
-MINIMAL. FOCAL
-SLIGHT
-SLIGHT
>ONE PRESENT
-EXTRAMEOULLARY HEMATOPOIESIS -ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) INFLAMMATORY FOCI ASSOC W SINGLE CELL NECROSIS
-NASAL LUMEN: FREE ERYTHROCYTES
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: COAGULATING GL. EPIDIDYMIDES, KIDNEYS, LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1, PITUITARY GLAND, PROSTATE GLAND,
SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: **M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. MI-" INVASIVE. HX-H OTHER
BFG 003303
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 32
STUDY NUMBER: 964060
ANIMAL NUMBER: 1002 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: S39.4 GRAMS
ORGAN NAME
* * * PATHOLOG KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GROSS/MICRO CORfi
MICRO
H1ST0PATH0L0GICAL COMMENT: >KIDNEY-L: IRREGULAR SHAPE/NMC
KIONEYS
GROSS -IRREGULAR SHAPE
-LEFT
LIVER
MICRO -MINIMAL, FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS
LUNGS
MICRO -SLIGHT
-CONGESTION
NOSE/TURB SEC 4
MICRO -MINIMAL
-NASAL MUCOSA (RESPIRATORY): BASOPHILIC MATERIAL
TRACHEA
MICRO: -MINIMAL, FOCAL
-MUCOSA: MUCOSAL GLANDS-OILATEO
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, KIDNEYS, MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, NOSE/TURB SEC 3,
PITUITARY GLAND. PROSTATE GLAND. SEMINAL VESICLES, TESTES
KEY TO NEOPLASMS: mM-m MALIGNANT, "B-" BENIGN.
METASTATIC. "I-" INVASIVE. MX-" OTHER
BFG 003304
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 33
STUDY NUMBER: 964080
ANIMAL NUMBER: 1003 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BOOT WEIGHT: 493.5 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWOROS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIOIOYMIDES .
MICRO:
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
LIVER . . . .
MICRO: -MINIMAL, FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS
-MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
NOSE/TURB SEC 2
MICRO: -MINIMAL, FOCAL
-NASOLACRIMAL OUCT(S): INFLAMMATORY CELLS/CELL DEBRIS
NOSE/TURB SEC 3
MICRO: -MINIMAL
-NASAL MUCOSA (RESPIRATORY!1: EPITHELIUM-INTRACYT0PLASM1C
EOS 1NOPHLIC MATERIAL
-SLIGHT
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
NOSE/TURB SEC 4
MICRO: -SLIGHT
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
PROSTATE GLAND
MICRO: -MINIMAL, FOCAL
-LYMPHOID CELL INFILTRATE(S)/AGGREGATE(S)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: COAGULATING GL, EPIOIOYMIDES, KIDNEYS. LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1, PITUITARY GLAND, SEMINAL VESICLES,
TESTES, TRACHEA
KEY TO NEOPLASMS: "H-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "1-" INVASIVE, "X-" OTHER
BFG 003305
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 34
STUDY NUMBER: 964080
ANIMAL NUMBER: 1004 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: S60.6 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIOYMIDES MICRO:
GROSS/MICRO CORR MICRO:
KIDNEYS MICRO:
LIVER . . MICRO:
LUNGS MICRO:
NOSE/TURB SEC 2 MICRO:
NOSE/TURB SEC 3 MICRO:
NOSE/TURB SEC 4 MICRO:
THYMUS
GROSS: MICRO:
HISTOPATHOLOGICAL COMMENT: HISTOPATHOLOGICAL COMMENT: -MINIMAL, FOCAL -MINIMAL. MULTI-FOCAL -MINIMAL -MINIMAL. FOCAL -MODERATE -SLIGHT -MODERATE -SLIGHT -MINIMAL
-SLIGHT
-DISCOLORED -MINIMAL. MULTI-FOCAL
>ONE PRESENT
>THYMUS: OISCOLORED/HEMORRHAGE HFOC
-U: PYELITIS,SUBACUTE
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-PULMONARY VESSELS: MINERAL DEPOSIT(S)
-NASOLACRIMAL DUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
-VOMORONASAL ORGAN: EOSINOPHILIC MATERIAL -ODONTOPATHY
-NASOLACRIMAL DUCT: LYMPHOIO HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-RED -HEMQRRHAGE(S)
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. MAMMARY GLANDS, NOSE/TURB SEC 1, PITUITARY GLAND, PROSTATE GLAND. SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN.
METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003306
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 35
STUDY NUMBER: 964080
ANIMAL NUMBER: 1005 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 545.1 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC F1N0INGS
EPIDIDYMIDES KIDNEYS LIVER NOSE/TURB SEC I NOSE/TURB SEC 2
NOSE/TURB SEC 3 PROSTATE GLAND
MICRO MICRO MICRO MICRO MICRO
MICRO: MICRO:
-MINIMAL, -MINIMAL -MINIMAL,
-MINIMAL, -MINIMAL, -SLIGHT
-MINIMAL,
HISTOPATHOLOGICAL COMMENT; FOCAL
FOCAL FOCAL FOCAL
FOCAL
>0N PRESENT -CORTEX: INFILTRATES,SUBACUTE
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -VOMORONASAL ORGAN: FREE"ERYTHROCYTES
-NASAL LUMEN: FREE ERYTHROCYTES -VOMORONASAL ORGAN: EOSINOPHILIC MATERIAL -NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA -LYMPHOID CELL'INFiLTRATE(S)/AGGREGATE(S)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIQIOYMIDES. LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 4. PITUITARY GLAND. SEMINAL VESICLES. TESTES,
TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE. "X-M OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 36
STUDY NUMBER: 964060
ANIMAL NUMBER: 1006 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BOOY WEIGHT: 433.6 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIOYHIDES . MICRO:
KIDNEYS . . . MICRO:
LIVER . . . . MICRO:
NOSE/TURB SEC 2 MICRO:
NOSE/TURB SEC 3 MICRO:
HISTOPATKOLOGICAL COMMENT:
-MINIMAL, FOCAL
-MINIMAL, MULTI-FOCAL -MINIMAL
-MODERATE
-MODERATE
-SLIGHT -SLIGHT
>ONE PRESENT
-DILATED TUBULES
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASOLACRIMAL OUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE}/ CHRONIC INFLAMMATION -ODONTOPATHY
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA -NASOLACRIMAL OUCT{S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES. LUNGS. MAMMARY GLANOS. NOSE/TURB SEC 1. NOSE/TURB SEC 4, PITUITARY GLAND. PROSTATE GLAND, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: '*H-" MALIGNANT. "8-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003308
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 37
STUDY NUMBER: 964080
ANIMAL NUMBER: 1007 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: l
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF OEATH: 16
TERMINAL BOOY WEIGHT: 447.9 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC F1N0INGS
LIVER
MICRO: -MINIMAL, MULTI-FOCAL -MINIMAL
NOSE/TURB SEC 3
MICRO: -MINIMAL -SLIGHT
NOSE/TURB SEC 4 ...................... MICRO: -SLIGHT
TRACHEA
MICRO: -MINIMAL, FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-MUCOSA: MUCOSAL GLANDS-OILATED
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: COAGULATING GL. EPIDIDYMIDES. KIDNEYS. LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2. PITUITARY GLAND. PROSTATE GLAND. SEMINAL VESICLES, TESTES
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC, *'l-" INVASIVE, "X-" OTHER
BFG 003309
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 38
STUDY NUMBER: 964080
ANIMAL NUMBER: 1008 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: SOI.1 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES .................................................................................................................................................................................................................................
MICRO:
H1ST0PATH0L0GICAL COMMENT: >ONE PRESENT
LIVER ..............................................................................................................................................................................................................................................
MICRO: -MINIMAL, MULTI-FOCAL
-ACUTE/SUBACUTE INFLAMMATION
-MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
NOSE/TURB SEC 3 .........................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA
NOSE/TURB SEC 4 .........................................................................................................................................................................................................................
MICRO: -SLIGHT
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYT0PLASM1C
EOSINOPHILIC MATERIAL
-MINIMAL
-NASAL MUCOSA (RESPIRATORY): BASOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: COAGULATING GL, EPIDIDYMIDES, KIDNEYS, LUNGS, MAMMARY GLANOS, NOSE/TURB SEC 1, NOSE/TURB SEC 2. PITUITARY GLAND.
PROSTATE GLAND, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
ou't'oo o ia
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TUO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 39
STUDY NUMBER: 964080
ANIMAL NUMBER: 1009 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 546.8 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS ***
KEYWOROS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES .
MICRO:
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
KIDNEYS . . . MICRO:'-MINIMAL,'FOCAL.................................................... -CORTEX:' INFRTRATES j SUBACUTE
LUNGS . . . . MlCROi'-MINIMAL, MULTI-FOCAL....................................... -LYMPH010 CELL INFIITRATE(S)/AGGREGATESj
NOSE/TURB SEC 3 MICRO; -MINIMAL................................................................. -NASOLACRIMAL DUCT: LYMPHoio HYPERPLAsiA..................................
PROSTATE GLAND MICRO-.'-MINIMAL. MULTI-FOCAL....................................... -ALVEOLAR LUMENS': CORPORA AMYLACiA/MiNERALiZED GRANULES
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. LIVER. MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 2. NOSE/TURB SEC 4,
PITUITARY GLAND, SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-*' BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003311
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLOftIOE COMBINED INHALATION TUO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 40
STUDY NUMBER: 964080
ANIMAL NUMBER: 1010 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BOOT WEIGHT: 425.3 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES ..................................................................................................................................................................................................................................
MICRO:
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
EYES...................................................................................................................................................................................................................................................
GROSS: -OPACITY
-RIGHT LENS: FOCAL OPACITY
GROSS/MICRO CORR .........................................................................................................................................................................................................................
MICRO:
HISTOPATHOLOGICAL COMMENT: >SKIN: SORE VENTRAL CERVICAL/ULCERATIVE DERMATITIS
EYE-R: OPACITY/NMC
NOSE/TURB SEC 1 .........................................................................................................................................................................................................................
MICRO: -MINIMAL, FOCAL
-VOMORONASAL ORGAN: FREE ERYTHROCYTES
-MINIMAL. FOCAL
-NASOLACRIMAL OUCT(S): FREE ERYTHROCYTES
NOSE/TURB SEC 3 .............................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASOLACRIMAL OUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/
CHRONIC INFLAMMATION
-MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
NOSE/TURB SEC 4 .........................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
SKIN...................................................................................................................................................................................................................................................
GROSS: -SCAB(S)/SORE(S)
-SORE. VENTRAL CERVICAL: TAN
MICRO: -MODERATE, FOCAL
-ULCERATIVE DERMATITIS
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIOIDYMIDES, EYES, KIDNEYS, LIVER. LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 2, PITUITARY GLAND,
PROSTATE GLAND. SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "H-" MALIGNANT, "B-m BENIGN, "S-" METASTATIC. "I-" INVASIVE. 'X-' OTHER
BFG 003312
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 41
STUDY NUMBER: 964080
ANIMAL NUMBER: 1011 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BOOY WEIGHT: 426.2 6RAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FIN01NGS
EPIDIDYMIDES
MICRO
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
KIDNEYS
MICRO -MINIMAL, FOCAL
-CORTEX: INF!LTRATES,SUBACUTE
LIVER
MICRO: -MINIMAL, MULTI-FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
MAMMARY GLANDS
MICRO: -TISSUE HISSING
NOSE/TURB SEC 2 MICRO: -MINIMAL, FOCAL
-VOMERONASAL ORGAN: FREE ERYTHROCYTES
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIOIDYMIDES, LUNGS. NOSE/TURB SEC 1, NOSE/TURB SEC 3. NOSE/TURB SEC 4, PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-M OTHER
BFG 003313
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 42
STUDY NUMBER: 964080
ANIMAL NUMBER: 1012 DATE OF DEATH: 04/29/97
SEX: HALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 113
STUDY WEEK OF OEATH: 17
TERMINAL BODY WEIGHT: 574.0 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWOROS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES
MICRO:
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
LIVER . .
MICRO: -MINIMAL. MULTI-FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS
-MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
NOSE/TURB SEC 3 MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPJTHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
NOSE/TURB SEC 4
MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIOIOYMIDES, KIDNEYS, LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2, PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES, TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "8-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003314
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 43
STUOY NUMBER: 964080
ANIMAL NUMBER: 1013 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BOOT WEIGHT: 488.2 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES
MICRO
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
LIVER
MICRO -SLIGHT
-HEPATOCYTES: CYTOPLASMIC VACUOLES {N0N-20NAL)
NOSE/TURB SEC 4 MICRO -SLiGHT
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
PROSTATE GLAND MICRO: -MINIMAL, FOCAL
-LYMPHOIO CELL INFILTRATE(S)/AGGREGATE(S)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. KIDNEYS. LUNGS, MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 2. NOSE/TURB SEC 3.
PITUITARY GLANO. SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. *'S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003315
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BFG 003316
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 45
STUDY NUMBER: 964080
ANIMAL NUMBER: 1015 DATE OF DEATH: 04/Z8/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY OAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 493.0 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS . . . MICRO: -MINIMAL, FOCAL
LIVER . . . . MICRO: -MINIMAL,'MULTI-FOCAL
-SLIGHT LUNGS . . . .
MICRO:'-MINIMAL,'FOCAL'
MAMMARY GLANDS MICRO: -TISSUE MISSING
NOSE/TURB SEC 1 MICRO: -SLIGHT^ FOCAL
NOSE/TURB SEC 2 MICRO: -SLIGHT..........................
NOSE/TURB SEC 3 MICRO: -MINIMAL
NOSE/TURB SEC 4 MICRO; -SLIGHT..........................
-U: PYELITIS,SUBACUTE -ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -INTERSTITIUM: MINERAL OEPOSIT(S)/OSSEOUS METAPLASIA
-NASOLACRIMAL OUCT(S): FREE ERYTHROCYTES -NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES -NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYT0PLASM1C
EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES, TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "0-" BENIGN, "S-" METASTATIC, "1-" INVASIVE, "X-" OTHER
BFG 003317
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 46
STUDY NUMBER: 964080
ANIMAL NUMBER: 1016 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: S70.9 GRAMS
ORGAN NAME
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER .......................................................................... MICRO: -MINIMAL, MULTI-FOCAL -SLIGHT
NOSE/TURB SEC 2 ..................................................... MICRO: -MINIMAL
NOSE/TURB SEC 3 ..................................................... MICRO: -MINIMAL -SLIGHT
NOSE/TURB SEC 4 .................................................... MICRO: -SLIGHT
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-VOHORONASAL ORGAN: EOSINOPHILIC MATERIAL
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: COAGULATING GL. EPIDIDYMIDES, KIDNEYS, LUNGS, MAMMARY GLANDS. NOSE/TURB SEC 1, PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT.
BENIGN. "S-" METASTATIC, "I-'' INVASIVE, "X-" OTHER
BFG 003318
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 47
STUDY NUMBER: 964080
ANIMAL NUMBER: 1017 OATE OF DEATH: 04/28/97
ORGAN NAME
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 535.2 GRAMS
* * * PATHOLOGY OBSERVATIONS * * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . . .
MICRO: -MINIMAL. MULTI-FOCAL
-MINIMAL
LUNGS
.. .. micr6:"-hinihal,'focal'
NOSE/TURB SEC 2 MICRO: -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-LYMPHOID CELL INFILTRATE(S)/AGGREGATE(S)
-VOMORONASAL ORGAN: EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. KIDNEYS. MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 3. NOSE/TURB SEC 4. PITUITARY GLAND, PROSTATE GLANO, SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "8-'* BENIGN,
METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003319
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 48
STUDY NUMBER: 9640B0
ANIMAL NUMBER: 1018 DATE OF DEATH; 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH; 112
STUDY WEEK OF DEATH: IB
TERMINAL BODY WEIGHT: 486.2 GRAMS
ORGAN NAME
*** PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER MICRO: -MINIMAL, MULTI-FOCAL -SLIGHT
LUNGS MICRO -MINIMAL, FOCAL
NOSE/TURB SEC 3 MICRO -MINIMAL.FOCAL'
NOSE/TURB SEC 4 MICRO '-SLIGHT....................
PITUITARY GLAND MICRO: -MINIMAL, FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-PULMONARY VESSELS: MINERAL DEPOSIT(S) -NASALMUCOSA (OLFACTORYj:'EPITHCtiuH DEGENERATION'
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-PARS DISTALIS: CYSTS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, KIDNEYS. MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, PROSTATE GLAND, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE. HX- OTHER
BFG 003320
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 49
STUDY NUMBER: 964080
ANIMAL NUMBER: 1019 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS; SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 499.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER ...................................................................... MICRO: -MINIMAL
NOSE/TURB SEC 1 ............................................. MICRO: -MINIMAL. FOCAL
NOSE/TURB SEC 2 ............................................. MICRO: -MINIMAL
NOSE/TURB SEC 3 ............................................. MICRO: -MINIMAL. FOCAL
NOSE/TURB SEC 4 ............................................. MICRO: -SLIGHT
PROSTATE GLAND .................................................. MICRO: -MINIMAL. FOCAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASAL MUCOSA (RESPIRATORY): ACUTE/SUBACUTE INFLAMMATION
-NASOLACRIMAL OUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASM IC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-ALVEOLAR LUMENS: CORPORA AMYLACIA/MINERALIZED GRANULES
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. KIDNEYS, LUNGS. MAMMARY GLANDS. PITUITARY GLANO. SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. *'I-** INVASIVE. "X-'* OTHER
BFG 003321
ANIMAL NUMBER: 1020 DATE OF DEATH: 04/28/97
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TVO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INOIVIOUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 50
STUDY NUMBER: 964080
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEOULEO, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BOOY WEIGHT:
516.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
LIVER LUNGS NOSE/TURB SEC 2 NOSE/TURB SEC 3 NOSE/TURB SEC 4
MICRO: MICRO MICRO MICRO MICRO
-MINIMAL -MINIMAL. FOCAL -SLiGHTi FOCAL
-MINIMAL -MINIMAL
PROSTATE GLAND MICRO: -MINIMAL, FOCAL
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NGN-ZONAL) -LYMPHOID CELL INFILTRATE(S)/AGGREGATE(S) -NASOLACRIMAL DUCT(Sj:'FREE ERYTHROCYTES' -NASOLACRIMAL DUCT: LYMPHOiD HYPERPLAsiA
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASHIC EOSINOPHILIC MATERIAL
-LYMPHOIO CELL INFILTRATE(S)/AGGREGATE(S)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED:
COAGULATING GL. EPIDIDYMIDES. KIDNEYS. MAMMARY GLANDS, NOSE/TURB SEC 1. PITUITARY GLAND. SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC, MI-" INVASIVE, "X-" OTHER
BFG 003322
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 51
STUDY NUMBER: 964080
ANIMAL NUMBER: 1021 OATE OF OEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
482.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER MICRO: -MINIMAL, MULTI-FOCAL
NOSE/TURB SEC 1 ............................................................ MICRO: -SLIGHT, FOCAL
NOSE/TURB SEC 2 ............................................................ MICRO: -SLIGHT
NOSE/TURB SEC 3 ............................................................ MICRO: -MINIMAL -SLIGHT
NOSE/TURB SEC 4 ............................................................ MICRO: -SLIGHT -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION
-ODONTOPATHY
-ODONTOPATHY
-NASOLACRIMAL OUCT: LYMPHOID HYPERPLASIA -NASOLACRIMAL DUCT{S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/
CHRONIC INFLAMMATION
-NASAL LUMEN: FREE ERYTHROCYTES -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASHIC
EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, KIDNEYS, LUNGS, MAMMARY GLANDS. PITUITARY GLAND. PROSTATE GLAND, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
BFG 003323
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: 52
STUDY NUMBER: 964080
ANIMAL NUMBER: 1022 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUOY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
529.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER MICRO: -MINIMAL, MULTI-FOCAL -MINIMAL. FOCAL
NOSE/TURB SEC 2 MICRO: -MINIMAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. KIDNEYS, LUNGS, MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 3, NOSE/TURB SEC 4, PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003324
ANIMAL NUMBER: 1023 DATE OF DEATH: 04/29/97
ORGAN NAME
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 53
STUOY NUMBER: 964080
SEX: HALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 451.8 GRAMS
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
MICRO: LIVER ..............................
MICRO:
NOSE/TURB SEC 4 MICRO:
-MINIMAL -MINIMAL
-MINIMAL
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (RESPIRATORY): BASOPHILIC MATERIAL
ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIOIOYMIOES, KIONEYS. LUNGS. MAMMARY GLANDS. NOSE/TUR0 SEC 1. N0SE/TUR8 SEC 2, NOSE/TURB SEC 3. PITUITARY GLANO, PROSTATE GLAND, SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
BFG 003325
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 54
STUDY NUMBER: 964060
ANIMAL NUMBER: 1024 OATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 469.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER MICRO:
NOSE/TURB SEC 1 MICRO:
NOSE/TURB SEC 3 MICRO:
-SLI6HT -MINIMAL -MINIMAL
NOSE/TURB SEC 4 MICRO: -MINIMAL
PITUITARY GLAND MICRO: -MINIMAL, FOCAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-VOMORONASAL ORGAN: FREE ERYTHROCYTES
-NASAL MUCOSA (OLFACTORY) : EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY) : EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-PARS OISTALIS: CYSTS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES, KIDNEYS. LUNGS. MAMMARY GLANDS, N0SE/TUR8 SEC 2. PROSTATE GLAND, SEMINAL VESICLES.
TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN, "S-M METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003326
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 5S
STUDY NUMBER: 964080
ANIMAL NUMBER- 1025 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUQY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 511.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . . . MICRO: -MINIMAL
NOSE/TURB SEC 3 MICRO:'-MINIMAL,'FOCAL
-MINIMAL
NOSE/TURB SEC 4 .............................. MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASOLACRIMAL DUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYT0PLASM1C EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASM IC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, KIDNEYS. LUNGS. MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 2. PITUITARY GLAND,
PROSTATE GLAND, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE, "X-M OTHER
BFG 00.1327
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-96 PAGE: 56
STUDY NUMBER: 964080
ANIMAL NUMBER: 1026 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY OAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
456.8 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER ................................................................................................................................................................................................................................................................................
MICRO: -MINIMAL, MULTI-FOCAL
-ACUTE/SUBACUTE INFLAMMATION
-MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
NOSE/TURB SEC 2 .......................................................................................................................................................................................................................................................
MICRO: -SLIGHT
-NASOLACRIMAL OUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/
CHRONIC INFLAMMATION
-MINIMAL
-NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
NOSE/TURB SEC 3 .......................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA
NOSE/TURB SEC 4 .......................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-1NTRACYT0PLASMIC
EOSINOPHILIC MATERIAL
PROSTATE GLAND ..................................................
MICRO: -MINIMAL. FOCAL
-LYMPHOID CELL INFILTRATE(S)/AGGREGATE(S)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, KIONEYS, LUNGS. MAMMARY GLANDS, N0SE/TUR8 SEC 1, PITUITARY GLAND. SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "I-" INVASIVE. "X-M OTHER
BFG 003328
*** PATH/TOX SVSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 57
STUOY NUMBER: 964060
ANIMAL NUMBER: 1027 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 4S4.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES MICRO
KIDNEYS . . MICRO
LIVER . . . MICRO:
NOSE/TUR0 SEC 4 MICRO:
-MINIMAL. -MINIMAL -MINIMAL
HISTOPATHOLOGICAL COMMENT: FOCAL
>ONE PRESENT -CORTEX: INFILTRATES.SUBACUTE -HEPATOCYTES: CYTOPLASMIC VACUOLES'(NON-ZONAL)
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES, LUNGS. MAMMARY GLANDS. NOSE/TURB SEC 1, NOSE/TURB SEC 2. NOSE/TURB SEC 3. PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, **l-" INVASIVE. "X-" OTHER
BFG 003329
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 56
STUDY NUMBER: 964080
ANIMAL NUMBER: 1028 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
496.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LIVER . . . . MICRO: -MINIMAL, MULTI-FOCAL -MINIMAL
NOSE/TURB SEC 3 MICRO:"-MINIMAL
-MINIMAL. FOCAL NOSE/TURB SEC 4
MICRO: -SLIGHT...................................
-MINIMAL. FOCAL PROSTATE GLAND
MICRO: -MODERATE] MULTI-FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASHIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (RESPIRATORY): BASOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASHIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL
-LYMPHOID CELL INF ILTRATE(S)/AGGREGATE(S)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, KIDNEYS. LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2. PITUITARY GLAND.
SEMINAL VESICLES, TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003330
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 59
STUDY NUMBER: 964080
ANIMAL NUMBER: 1029 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 489.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . . .
NOSE/TURB SEC 3 NOSE/TURB SEC 4
MICRO:
MICRO: MICRO:
-MINIMAL. -MINIMAL
-MINIMAL
-SLIGHT
MULTI-FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA
-NASAL MUCOSA (OLFACTORYj: EP1THELIUM-INTRACYT0PLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, KIDNEYS. LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, PITUITARY GLAND. PROSTATE GLAND. SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, MB-'* BENIGN, "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003331
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IK CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 60
STUDY NUMBER: 964060
ANIMAL NUMBER: 1030 DATE OF OEATH: 04/29/97
ORGAN NAME
SEX: MALE
OOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BOOT WEIGHT: 4B0.9 GRAMS
* * * PATHOLOGY KEYWOROS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS . . . MICRO:
LIVER . . . . MICRO:
NOSE/TURB SEC 2 MICRO:
NOSE/TURB SEC 3 MICRO:
NOSE/TURB SEC 4 MICRO:
MINIMAL, -MINIMAL, -MINIMAL -MINIMAL
-MINIMAL -SLIGHT
FOCAL MULTI-FOCAL
-HEOULLA: CYST
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
-NASOLACRIMAL OUCT: LYMPHOIO HYPERPLASIA
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1. PITUITARY GLAND. PROSTATE GLANO. SEMINAL VESICLES
, TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "8-'' BENIGN. `V METASTATIC. "I-" INVASIVE, "X-`* OTHER
BFG 003332
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 61
STUDY NUMBER: 964080
ANIMAL NUMBER: 2001 DATE OF DEATH: 04/26/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF OEATH: 16
TERMINAL BODY WEIGHT:
543.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS *** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
.......................................................................... MICRO: -MINIMAL. FOCAL -MINIMAL, FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS -ACUTE/SUBACUTE INFLAMMATION
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-* ' MALIGNANT. "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE. "X-H OTHER
BFG 003333
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHL0RI0E CQNBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-90 PAGE: 62
STUDY NUMBER: 964080
ANIMAL NUMBER: 2002 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL 600Y WEIGHT:
451.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
................................................................................................................................................................................................................
MICRO: -MINIMAL, FOCAL
-EXTRAMEOULLARY HEMATOPOIESIS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-' * MALIGNANT, "B-" BENIGN. "S-M METASTATIC. "I-" INVASIVE, "X-" OTHER
B F G 003334
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 63
STUOY NUMBER: 964080
ANIMAL NUMBER: 2003 DATE OF DEATH; 04/28/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 536.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO; -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT. "8-" BENIGN,
METASTATIC, Ml-" INVASIVE, "X-" OTHER
BFG 003335
* * * PATH/TOX SYSTEM OUTPUT * * *
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
PRINTED: 29-APR-98 PAGE: 64
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*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 65
STUOY NUMBER: 964030
ANIMAL NUMBER: 2005 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
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TERMINAL BODY WEIGHT: 495.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
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LIVER . .
MICRO: -MINIMAL, FOCAL -MINIMAL
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*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
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ANIMAL NUMBER: 2007 DATE OF DEATH: 04/28/97
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: B7
STUDY NUMBER: 964080
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
549.6 GRAMS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED *** *** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
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*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 70
STUDY NUMBER: 964060
ANIMAL NUMBER: 2010 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 441.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LIVER . .
MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 00334
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 71
STUOY NUMBER: 964080
ANIMAL NUMBER: 2011 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUOY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 437.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
................................................................................................................................................................................................................
MICRO: -MINIMAL. FOCAL
-EXTRAMEOULLARY HEMATOPOIESIS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-' * MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, 'X-" OTHER
BFG 003343
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 72
STUDY NUMBER: 964060
ANIMAL NUMBER: 2012 DATE OF DEATH: 04/29/97
SEX: MALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: NOT ENTERED
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL. FOCAL -MINIMAL
-EXTRAMEDULLARY HEMATOPOIESIS -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-M BENIGN. "S-" METASTATIC. "I-'* INVASIVE. "X-" OTHER
BFG 003344
ANIMAL NUMBER: 2013 DATE Of DEATH: 04/29/97
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 73
STUDY NUMBER: 964080
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
483.9 GRAMS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED *** *** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
BFG 003345
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: 74
STUDY NUMBER: 964080
ANIMAL NUMBER: 2014 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEOULEO, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 495.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL, FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN, MS-M METASTATIC. "I-" INVASIVE, "X-" OTHER
BFG 003346
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 75
STUDY NUMBER: 964080
ANIMAL NUMBER: 2015 DATE OF DEATH: 04/28/97
SEX: MALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 471.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . ,
MICRO: -MINIMAL, FOCAL
-ACUTE/SUBACUTE INFLAMMATION
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT, ''B-'' BENIGN, "S-" METASTATIC. "I-" INVASIVE, **X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 76
STUDY NUMBER: 964080
ANIMAL NUMBER: 2016 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
SIX.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
AOIPOSE TISSUE LIVER . . .
GROSS: -NODULE(S)/HASS(ES)
MICRO: -MINIMAL, FOCAL -MINIMAL
-NODULE, ABDOMINAL: 0.2 X 0.4 CM, TAN, FIRM
-EXTRAMEDULLARY HEMATOPOIESIS -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
KEY TO NEOPLASMS: ,,M-m MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. HX-M OTHER
BFG 003348
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE CON8INED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98
PAGE: 77
STUDY NUMBER: 964080
ANIMAL NUMBER: 2017 DATE OF DEATH: 04/28/97
SEX; MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 535.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EYES........................................ GROSS: -OPACITY
LIVER ................................... MICRO: -MINIMAL
-LEFT CORNEA: FOCAL, MINIMAL -HEPATOCYTES; CYTOPLASMIC VACUOLES (NON-ZONAL)
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. MS-" METASTATIC. "I-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 78
STUDY NUMBER: 964080
ANIMAL NUMBER: 2018 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF OEATH: 16
TERMINAL BOOY WEIGHT: 588.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZQNAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. MS-M METASTATIC, "I-" INVASIVE, "X-" OTHER
003350
ANIMAL NUMBER: 2019 OATE OF DEATH: 04/28/97
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: 79
STUDY NUMBER: 964080
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BOOY WEIGHT: S3B.7 GRAMS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED *** *** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 80
STUDY NUMBER: 964080
ANIMAL NUMBER: 2020 DATE OF DEATH: 04/29/9T
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF DEATH: 113
STUDY WEEK OF OEATH: 17
TERMINAL BOOT WEIGHT: 526.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL, FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS
*** ANIMAL HAS NO GROSS ABNORMALITIES <OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE, "X-M OTHER
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BFG 003353
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: 82
STUDY NUMBER: 964080
ANIMAL NUMBER: 2022 OATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 598.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -MINIMAL. FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-'' MALIGNANT. "B-" BENIGN, "S-" METASTATIC. "I-" INVASIVE, "X-" OTHER
BFG 003354
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 63
STUDY NUMBER: 964060
ANIMAL NUMBER: 2023 DATE OF DEATH: 04/28/97
ORGAN NAME
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 523.2 GRAMS
* * * PATHOLOGY KEYUOROS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -SLIGHT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-* ' MALIGNANT, "B-" BENIGN. "S-" METASTATIC. "I-** INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INOIVIOUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 84
STUDY NUMBER: 964080
ANIMAL NUMBER: 2024 DATE OF DEATH: 04/26/97
SEX: MALE
OOSE GROUP: 2
SACRIFICE STATUS: UNSCHEDULED (D)
STUDY DAY OF OEATH: 110
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
405.3 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EXTREMITY . . KIDNEYS . . .
URINARY BLADDER
GROSS: GROSS:
GROSS:
-SWOLLEN. SLIGHT
-ENLARGED, SLIGHT -DILATATION
-DISTENDED, SEVERE
-RIGHT HINDPAW
-BOTH -RIGHT PELVIS: EXTREME; LEFT PELVIS: MODERATE
-WITH THIN RED FLUID
*** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
BFG 003356
00
BFG 003357
ANIMAL NUMBER: 2025
DATE OF DEATH: 0 4 /2 9 /9 7
SEX: HALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: S 2 1 .6 GRAMS
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-9B PAGE: 86
STUDY NUMBER: 964060
ANIMAL NUMBER: 2026 OATH OF OEATH: 04/29/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUOY WEEK OF DEATH: 17
TERMINAL BOOT WEIGHT:
631.8 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -MINIMAL, FOCAL -SLIGHT
-EXTRAMEDULLARY HEMATOPOIESIS -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-' ' MALIGNANT. "B-" BENIGN, "S-M METASTATIC. "I-" INVASIVE, "X-" OTHER
BFG 003358
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 87
STUDY NUMBER: 964080
ANIMAL NUMBER: 2027 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEOULEO. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BOOY WEIGHT: 431.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EXTREMITY LIVER . .
GROSS: -HAIR ABSENT/THIN, SLIGHT MICRO: -MINIMAL, FOCAL
-HAIR ABSENT, BOTH FOREPAUS -EXTRAMEDULLARY HEMATOPOIESIS
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-*' INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 08
STUDY NUMBER: 964080
ANIMAL NUMBER: 2028 DATE OF DEATH: 04/29/97
SEX: HALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEOULEO, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 490.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . MICRO: -MINIMAL
SEMINAL VESICLES . . . GROSS: -SHALL, MODERATE
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -LEFT HORN
KEY TO NEOPLASMS: "M-" MALIGNANT, *'B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003360
ANIMAL NUMBER: 2029 DATE OF DEATH: 04/29/97
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 89
STUDY NUMBER: 964080
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF OEATH: 113
STUDY WEEK OF OEATH: 17
TERMINAL BODY WEIGHT:
439.2 GRAMS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO *** *** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 90
STUDY NUMBER: 964080
ANIMAL NUMBER: 2030 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: Z
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 113
STUOY WEEK OF OEATH: 17
TERMINAL BODY WEIGHT:
S29.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
........................................................................................................................................................................................................................................................
MICRO: -MINIMAL. FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS
-MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-'* MALIGNANT, "B-" 8ENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
B F G 00.1362
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 91
STUDY NUMBER: 964080
ANIMAL NUMBER: 3001 DATE OF DEATH: 04/28/97
SEX: HALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
493.8 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: *'M-'" MALIGNANT. "B-" BENIGN, "S-" METASTATIC. "I-'* INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TU0-6ENERATI0N REPRODUCTION AND OEVELOPHENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 92
STUOY NUMBER: 964080
ANIMAL NUMBER: 3002 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF DEATH: 112
STUDY WEEK OF OEATH: 16
TERMINAL BODY WEIGHT:
561.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
.......................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-' ' MALIGNANT. MB-" BENIGN. "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
BFG 003364
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINEO INHALATION TVO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 93
STUDY NUMBER: 964060
ANIMAL NUMBER: 3003 DATE OP DEATH: 04/28/97
SEX: MALE
OOSE GROUP: 3
SACRIFICE STATUS:: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 515.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL. FOCAL
-PELIOSIS HEPATIS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN, "S-M METASTATIC, "I-M INVASIVE. "X-" OTHER
BFG 003365
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 94
STUOY NUMBER: 964080
ANIMAL NUMBER: 30D4 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 531.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALI6NANT, "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003366
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRIHTEO: 29-APR-9B PAGE: 9S
STUDY NUMBER: 964080
ANIMAL NUMBER: 3005 DATE OF OEATH: 04/28/97
SEX: HALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 552.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
.....................................................................
MICRO: -MINIMAL, FOCAL -MINIMAL
ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR; HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M- MALIGNANT, "B-" BENIGN, MS-M METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003367
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 95
STUOY NUMBER: 964060
ANIMAL NUMBER: 3006 DATE OF OEATH: 04/28/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 490.B GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS LIVER . .
GROSS: -DILATATION. MOOERATE MICRO: -MINIMAL, FOCAL
-RIGHT PELVIS -ACUTE/SUBACUTE INFLAMMATION
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "1-** INVASIVE. "X-" OTHER
BFG 003368
*** PATH/TOX SYSTEM OUTPUT ** VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: 97
STUOY NUMBER: 964080
ANIMAL NUMBER: 3007 DATE OF 0EA7H: 04/18/97
SEX: MALE
OOSE GROUP: 3
SACRIFICE STATUS: SCHEOULEO, TERMINAL SACRIFICE
SlUOt DAY OF DEATH: U2
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
S41.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL, FOCAL
-ACUTE/SUBACUTE INFLAMMATION
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, MS-M METASTATIC, "I-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 98
STUDY NUMBER: 964080
ANIMAL NUMBER: 3008 DATE OF DEATH: 04/28/97
SEX: HALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAT OF OEATH: 112
STUOT WEEK OF DEATH: 16
TERMINAL BOOT WEIGHT: 533.2 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC F1NQINGS
LIVER . .
MICRO: MINIMAL. FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-** OTHER
BFG 003370
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-6ENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PA6E: 99
STUDY NUMBER: 964080
ANIMAL NUMBER: 3009 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF OEATH: 17
TERMINAL BODY WEIGHT: 564.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC F1N0INGS
EARS LIVER
GROSS: -SWOLLEN, MODERATE
MICRO: -MINIMAL -MINIMAL
-BOTH
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBUIAR: HYPERTROPHY
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "J-M INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 100
STUDY NUMBER: 964080
ANIMAL NUMBER: 3010 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 439.3 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRIL08ULAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "H-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "1-" INVASIVE, "X-" OTHER
B FG 003372
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 1D1
STUDY NUMBER: 964060
ANIMAL NUMBER: 3011 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
522.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
..........................................................................................................................................................................................................
MICRO: -MINIMAL, FOCAL
-ACUTE/SUBACUTE INFLAMMATION
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT,
BENIGN. "S-M METASTATIC. "I-" INVASIVE. "X-" OTHER
PATH/TOX* * * SYSTEM OUTPUT * * *
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
PRINTED: 29-A P R -98 PA6E: 102
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BFG 003374
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TVO-GENERATJON REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 103
STUDY NUMBER: 964080
ANIMAL NUMBER: 3013 DATE OF DEATH: 04/28/97
SEX: HALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY HEIGHT: 512.2 6RAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -MINIMAL. FOCAL -MINIMAL -MINIMAL. FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZGNAL) -PElIOSIS HEPATIS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-' ' MALIGNANT. M8-" BENIGN, "S-H METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003375
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBIMEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIKAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 104
STUDY NUMBER: 964080
ANIMAL NUMBER: 3014 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY OAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
542.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
..................................................................... MICRO: -MINIMAL, FOCAL -MINIMAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZQNAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED *** KEY TO NEOPLASMS: ''M-' ' MALIGNANT. "8-" BENIGN, "S-" METASTATIC, "I-*' INVASIVE, "X-" OTHER
BFG 003376
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COM8INEO INHALATION TWO-GENERATION REPRODUCTION AHO DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 10S
STUDY NUMBER: 9640B0
ANIMAL NUMBER: 3015 OATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH; 212
STUDY WEEK OF DEATH: 16
TERMINAL BOOY WEIGHT: 501.4 GRANS
ORGAN NAME
"** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL. FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "H-" MALIGNANT, "8-" BENIGN. "S-" METASTArfC,
INVASIVE, "X-" OTHER
BFG 003377
* * * PATH/TOX SYSTEM OUTPUT * * *
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
PRINTED: 29-A P R -98 PA6E: 106
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BFG 003378
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PA6E: 107
STUDY NUMBER: 964080
ANIMAL NUMBER: 3017 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 112
STUDY WEEK OF OEATH: 15
TERMINAL BODY WEIGHT: 525.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -MINIMAL, FOCAL -MINIMAL, FOCAL -MINIMAL
-EXTRAMEOULLARY HEMATOPOIESIS -ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-' 1 MALIGNANT, "B-M BENIGN, V" METASTATIC. "I-" INVASIVE, "X-" OTHER
BFG 003379
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINEO INHALATION TW0-6ENERATI0N REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: LOS
STUDY NUMBER: 964080
ANIMAL NUMBER: 3018 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY OAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY HEIGHT:
562.4 GRANS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
.......................................................................... MICRO: -MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBUIAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-' ' MALIGNANT. "B-"' BENIGN. "S-" METASTATIC, "1-" INVASIVE. "X-" OTHER
BFG 003380
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE C0H8INE0 INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 109
STUDY NUMBER: 964060
ANIMAL NUMBER: 3019 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
S64.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -MINIMAL -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILQBULAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-** BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 110
STUDY NUMBER: 964080
ANIMAL NUMBER: 3020 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY OAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 473.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS *** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -MINIMAL -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: mM-' ' MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
B F G 003382
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 111
STUDY NUMBER: 9640B0
ANIMAL NUMBER: 3021 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY OAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
523.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
.......................................................................... MICRO: -MINIMAL, FOCAL SLIGHT
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
KEY TO NEOPLASMS: "K-`' MALIGNANT, "8-"' BENIGN,
METASTATIC, "l-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 112
STUDY NUMBER: 964080
ANIMAL NUMBER: 3022 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY OAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BOOT WEIGHT:
453.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL. FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003384
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 113
STUDY NUMBER: 964080
ANIMAL NUMBER: 3023 DATE OF OEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 495.8 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL
-HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE. "X-M OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 114
STUDY NUMBER: 964080
ANIMAL NUMBER: 3024 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 479.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL. FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES <OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. HS-M METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003386
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 115
STUDY NUMBER: 964080
ANIMAL NUMBER: 3025 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 521.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . .
MICRO: -MINIMAL, FOCAL -MINIMAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED *'*
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 116
STUDY NUMBER: 964060
ANIMAL NUMBER: 3026 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
371.3 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS . , . GROSS:
LIVER . . . . MICRO:
URINARY BLADDER GROSS:
-CALCULUS(CALCULI) -MINIMAL -CALCULUS(CALCULl)
MODERATE SEVERE
-BOTH PELVES -HEPATOCYTES CENTRiLOBULAR: HYPERTROPHY
KEY TO NEOPLASMS: "H-" MALIGNANT. "B-" BENIGN, "S-" METASTATIC. "1-" INVASIVE. "X-" OTHER
BFG 003388
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 117
STUDY NUMBER: 964080
ANIMAL NUMBER: 3027 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
489.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
.................................................................. MICRO: -MINIMAL, FOCAL -MINIMAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED *** KEY TO NEOPLASMS: "M-' ' MALIGNANT. "B-" BENIGN. "S-" METASTATIC, "1-" INVASIVE, "X-" OTHER
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BFG 003390
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 119
STUDY NUMBER: 964080
ANIMAL NUMBER: 3029 OATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEOULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF OEATH: 17
TERMINAL BODY WEIGHT: 513.3 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LIVER .
MICRO: -MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION HEPA70CYTES: CY70PIASHIC VACUOLES (NON-ZONAL)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC. "1-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 120
STUDY NUMBER: 964060
ANIMAL NUM8ER: 3030 DATE OF DEATH: 04/29/97
SEX: HALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BOOY WEIGHT: 513.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . TESTES . .
MICRO: -MINIMAL. FOCAL -MINIMAL
GROSS: -SMALL. MODERATE
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-BOTH
KEY TO NEOPLASMS: "M-" MALIGNANT, "e-" BENIGN, "S-" METASTATIC, "1-" INVASIVE, ''X-" OTHER
BFG 003392
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-9B PAGE: 121
STUDY NUMBER: 964080
ANIMAL NUMBER: 4001 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
481.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES LIVER . .
MICRO:
H1STOPATHOLOGICAL COMMENT: >ONE PRESENT
MICRO:'-MINIMAL.'FOCAL............................................................-ACUTE/SUBACUTE INFLAMMATION...............................................................
-MINIMAL
-HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
NOSE/TURB SEC 3 MICRO:'-MINIMAL ...................................................................... MISSAL'MUCOSA {OLFACTORYjEPITHELiuM-iNTRACYTOPLASMic
NQSE/TURB SEC 4 MICRO: -SLIGHT
EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIOYMIOES. KIONEYS, LUNGS. MAMMARY GLANOS, NOSE/TURB SEC 1. NOSE/TURB SEC 2. PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES, TESTES. TRACHEA
KEY TO NEOPLASMS: "H-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE. '*X-'` OTHER
BFG 003393
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-96 PAGE: 122
STUDY NUMBER: 964080
ANIMAL NUMBER: 4002 DATE OF OEATH: 04/26/97
SEX: HALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF OEATH: 16
TERMINAL BODY WEIGHT:
568.3 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIOIOYMIDES KIDNEYS . . LIVER . . .
MAMMARY GLANDS NOSE/TURB SEC 3
NOSE/TURB SEC 4
PROSTATE GLAND
TESTES ....
MICRO MICRO MICRO:
MICRO: MICRO:
MICRO:
MICRO:
MICRO:
H1STOPATHOLOG1CAL COMMENT: -MINIMAL, FOCAL -MINIMAL, FOCAL -MINIMAL -TISSUE MISSING -MINIMAL
-MINIMAL
-MINIMAL, MULTI-FOCAL -MINIMAL. FOCAL
HISTOPATHOLOGICAL COMMENT:
>ONE PRESENT -CORTEX: INFILTRATES.SUBACUTE
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EP1THELIUH-1NTRACYTOPLASHIC EOSINOPHILIC MATERIAL
-LYMPHOID CELL INF ILTRATE(S)/AGGREGATE(S) -ALVEOLAR LUMENS: CORPORA AMYLACIA/MINERAL I ZED GRANULES
>ONE PRESENT
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES, LUNGS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, PITUITARY GLAND. SEMINAL VESICLES, TESTES.
TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, `V METASTATIC, ''I-'' INVASIVE. "X-" OTHER
C
* 6
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 123
STUDY NUMBER: 964080
ANIMAL NUMBER: 4003 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEOULEO, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL 80DY WEIGHT: 562.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIOIOYMIOES . MICRO
KIDNEYS . . . MICRO: -MINIMAL
LIVER . . . . MICRO: -MINIMAL -MINIMAL -MINIMAL
NOSE/TURB SEC 3 MICRO: -MINIMAL
NOSE/TURB SEC 4 .............................. MICRO: -MINIMAL
HISTOPATHOLOGICAl COMMENT: >ONE PRESENT
MULTI-FOCAL
-INTERSTITIAL NEPHRITIS SUBACUTE
FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES, LUNGS, MAMMARY GLANDS. NOSE/TURB SEC 1, NOSE/TURB SEC 2. PITUITARY GLAND,
PROSTATE GLAND, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "H-" MALIGNANT. "B-" BENIGN, "S-" METASTATIC. "I-" INVASIVE, "X-" OTHER
BFG 003395
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: 124
STUDY NUMBER: 9640B0
ANIMAL NUMBER: 4004 DATE OF DEATH: 04/28/97
ORGAN NAME
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
538.4 GRAMS
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES MICRO
GROSS/MICRO CORR MICRO
LIVER .... MICRO:
MEDIASTINAL LN GROSS: MICRO:
NOSE/TURB SEC 3 MICRO:
NOSE/TURB SEC 4 MICRO:
PROSTATE GLAND MICRO:
TESTES .... MICRO:
-TISSUE MISSING .............................. HisTOPATHOLOGiCAL
-MINIMAL. FOCAL -MINIMAL
-OISCOLORED -SLIGHT -MINIMAL -MINIMAL
-MINIMAL
-MINIMAL
-MINIMAL. FOCAL -TISSUE'MisSING'
COMMENT:
>LN MEDIASTINAL: oisCOLORED/HEMORRHAGE'
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-RED -HEMORRHAGE(S)
-NASOLACRIMAL DUCT: LYMPHOIO HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL -NASOLACRIMAL OUCT(S): FREE ERYTHROCYTES
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-LYMPHOID CELL INFILTRATE{S)/AGGREGATE(S)
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. KIONEYS. LUNGS, MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 2. PITUITARY GLANO. SEMINAL VESICLES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. MS-''* METASTATIC. ''I-" INVASIVE. "X-" OTHER
BFG 003396
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: I2S
STUDY NUMBER: 964080
ANIMAL NUMBER: 4005 OATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BOOY WEIGHT:
465.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES MICRO
LIVER MICRO
NOSE/TURB SEC 1 MICRO
NOSE/TURB SEC 2 MICRO:
NOSE/TURB SEC 3 MICRO:
NOSE/TURB SEC 4 MICRO:
PROSTATE GLAND MICRO:
-MINIMAL -MINIMAL -SLIGHT -MINIMAL -SLIGHT
-SLI6HT
-MINIMAL,
H1STOPATHOLOGICAL COMMENT: FOCAL
>QNE PRESENT
-HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-ODONTOPATHY -NASAL MUCOSA (RESPIRATORY): GOBLET CELL HYPERTROPHY/HYPERPLASIA
-ODONTOPATHY
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-ALVEOLAR LUMENS: CORPORA AMYLACIA/MINERALIZEO GRANULES
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: COAGULATING GL, EPIDIOYMIOES, KIDNEYS. LUNGS, MAMMARY GLANOS. PITUITARY GLANO, SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "I-'' INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 126
STUDY NUMBER: 964080
ANIMAL NUMBER: 4006 DATE OF DEATH: 04/26/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCKEOULEO. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 536.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES LIVER . .
MAMMARY GLANDS
MICRO:
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
MICRO: -MINIMAL -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
MICRO: -TISSUE MISSING
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, KIDNEYS, LUNGS. NOSE/TURB SEC 1. NOSE/TURB SEC 2. NOSE/TURB SEC 3. NOSE/TURB SEC 4. PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. MB-" BENIGN. MS-M METASTATIC, "I-" INVASIVE, "X-H OTHER
BFG 003398
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 127
STUDY NUMBER: 964060
ANIMAL NUMBER: 4007 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEOULEO, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
518.2 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EP1DI0YMI0ES KIDNEYS . . LIVER . . .
N0SE/TUR6 SEC 1 NOSE/TURB SEC 2
NOSE/TURB SEC 3 NOSE/TURB SEC 4
PROSTATE GLANO TESTES . . .
MICRO: MICRO: MICRO:
MICRO: MICRO:
MICRO: MICRO:
MICRO: MICRO:
-TISSUE MISSING
-MINIMAL, FOCAL
-CORTEX: INFILTRATES.SUBACUTE
-MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATQCYTES CENTRlLOBULAR: HYPERTROPHY
-MINIMAL
-OOONTOPATHY
-MINIMAL -MINIMAL
-NASOLACRIMAL DUCT(S): INFLAMMATORY CELLS/CCLL 0E6RIS -ODONTOPATHY
-MINIMAL -MINIMAL
-NASOLACRIMAL DUCT: LYMPHOIO HYPERPLASIA
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPIASMIC EOSINOPHILIC MATERIAL
-MINIMAL. FOCAL
-ALVEOLAR LUMENS: CORPORA AMYLACIA/MINERAL I ZED GRANULES
-TISSUE Miss ING.......................................................................................................................
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, LUNGS. MAMMARY GLANDS, PITUITARY GLAND. SEMINAL VESICLES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC,
INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 128
STUDY NUMBER: 964080
ANIMAL NUMBER: 4008 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
530.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES ........................................................................................................................................................................................................................................
MICRO:
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
GROSS/MICRO CORR ...............................................................................................................................................................................................................................
MICRO:
HISTOPATHOLOGICAL COMMENT: >TESTES-L: ENLARGED/TUBULAR DEGENERATION
LIVER ........................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-MINIMAL
-HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
LUNGS ...........................................................................................................................................................................................................................................................................
MICRO: -MINIMAL. FOCAL
-PULMONARY VESSELS: MINERAL OEPOSIT(S)
N0SE/TUR8 SEC 4 ..................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
-MINIMAL
-NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL
TESTES ...........................................................................................................................................................................................................................................................................
GROSS: -ENLARGED, MODERATE
-LEFT
MICRO: -MODERATE
-U: TUBULAR DEGENERATION
-MODERATE
-REDUCEO SPERMATOGENESIS
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. KIDNEYS, MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 2, NOSE/TURB SEC 3,
PITUITARY GLANO, PROSTATE GLAND. SEMINAL VESICLES, TRACHEA
KEY TO NEOPLASMS: "M-M MALIGNANT, "B-" BENIGN. "$-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003400
*** PATK/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATJON REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 129
STUDY NUMBER: 964030
ANIMAL NUMBER: 4009 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULEO. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF OEATH: 17
TERMINAL BODY WEIGHT:
477.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
...........................................................................................................................................................................................................................................................................
MICRO: -MINIMAL, FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS
-MINIMAL, MULTI-FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRIL09ULAR: HYPERTROPHY
NOSE/TURB SEC 3 ..................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EP1THELIUM-INTRACYT0PLASMIC
EOSINOPHILIC MATERIAL
PITUITARY GLAND ............................................. MICRO: -MINIMAL, FOCAL
-PARS DISTALIS: CYSTS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EP10IDYMIDES, KIDNEYS, LUNGS. MAMMARY GLANDS, NOSE/TURB SEC I, NOSE/TURB SEC 2, NOSE/TURB SEC 4, PROSTATE GLAND, SEMINAL VESICLES, TESIES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "6~" BENIGN, "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
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BFG 003402
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 131
STUOY NUMBER: 964080
ANIMAL NUMBER: 4011 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 595.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES .
MICRO:
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
KIDNEYS
. .. MICRO: '-MINIMAL.'FOCAL............................................................-ORATED `TUBULES..........................................................
LIVER
.... MICRO: -SliGHTi MULTi-FOCAl.............................................-ACUTE/SUBACUTE INFLAMMATION............................
-MINIMAL
-HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
NOSE/TURB SEC 4 MICRO: -MINIMAL
-MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2, NOSE/TURB SEC 3.
PITUITARY GLAND. PROSTATE GLANO. SEMINAL VESICLES, TESTES. TRACHEA
KEY TO NEOPLASMS: "M-m MALIGNANT, "B-" BENIGN. "S-" METASTATIC. "1-*' INVASIVE, "X-" OTHER
BFG 00340.1
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TUO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 132
STUDY NUMBER: 964080
ANIMAL NUMBER: 4012 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP; 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT; 543-7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES . LIVER . . . . NOSE/TURB SEC 3 NOSE/TURB SEC 4 PROSTATE GLANO
MICRO: MICRO: MICRO: MICRO: MICRO:
HISTOPATH0LOGICAL COMMENT: -MINIMAL. FOCAL -MINIMAL -MINIMAL
-MINIMAL
-SLIGHT, MULTI-FOCAL
>ONE PRESENT
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASM IC EOSINOPHILIC MATERIAL
-LYMPHOID CELL INF ILTRATE(S)/AGGREGATE (S)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES, KIDNEYS, LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2. PITUITARY GLAND, SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "l-" INVASIVE, "X-M OTHER
BFG 003404
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 133
STUDY NUMBER: 964080
ANIMAL NUMBER: 4013 DATE OF DEATH: 04/29/97
SEX: MALE
OOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT: 566.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EP10I0YM1DES . MICRO:
LIVER . . . . MICRO: -MINIMAL -MINIMAL
NQSE/TURB SEC 3 MICRO: -MINIMAL
PROSTATE GLAND MICRO:'-MINIMAL
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL
FOCAL
-ACUTE/SUBACUTE INFLAMMATION
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. KIDNEYS, LUNGS. MAMMARY GLANDS, N0SE/TUR8 SEC 1, NOSE/TURB SEC 2, NOSE/TURB SEC 4, PITUITARY GLAND. SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS:
MALIGNANT. "fl-M BENIGN. "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 134
STUDY NUMBER: 964080
ANIMAL NUMBER: 4014 DATE OF DEATH: 04/29/97
SEX; MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
505.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES .........................................................................................................................................................................................................................................................................................
MICRO:
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
LIVER
........................................................................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
NOSE/TURB SEC 4 ................................................................................................................................................................................................................................................................................
MICRO: -SLIGHT-
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
PROSTATE GLAND .....................................................................................................................................................................................................................................................................................
MICRO: -MINIMAL, FOCAL
-ALVEOLAR LUMENS: CORPORA AMYLACIA/M1NERALIZED GRANULES
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: COAGULATING GL, EPIDIDYMIDES, KIDNEYS. LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2. NOSE/TURB SEC 3,
PITUITARY GLAND, SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN, "S-M METASTATIC, "I-" INVASIVE, MX-M OTHER
BFG 003406
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 135
STUDY NUMBER: 9640B0
ANIMAL NUMBER: 4015 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BQOY WEI6HT:
483.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER NOSE/TURB SEC 4
MICRO: MICRO:
-MINIMAL. -MINIMAL
-MINIMAL
FOCAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASAL LUMEN: FREE ERYTHROCYTES
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING 6L. EPIDIDYMIDES, KIONEYS, LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2. NOSE/TURB SEC 3.
PITUITARY GLAND. PROSTATE GLAND, SEMINAL VESICLES, TESTES. TRACHEA
KEY TO NEOPLASMS: "H-" MALIGNANT, "B-'* BENIGN. "S-M METASTATIC. "I-" INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 136
STUDY NUMBER: 964060
ANIMAL NUMBER: 4016 DATE OF DEATH: 04/26/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
549.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GROSS/MICRO CORR . .
MICRO:
HISTOPATHOLOGICAL COMMENT: >KIDNEYS: OILATATION/PELVIS OILATEO
PROSTATE: DISCOLOREO/ACUTE/SUBA INFLAMMATION
KIDNEYS .........................
GROSS: -DILATATION, MODERATE
-BOTH PELVES
MICRO: -MINIMAL, FOCAL
-U: PYELITIS.SUBACUTE
-MINIMAL, FOCAL
-INTERSTITIAL NEPHRITIS SUBACUTE
-MODERATE
-PELVIS DILATED
LIVER
MICRO: -MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
MAMMARY GLANDS
MICRO: -TISSUE MISSING
NOSE/TURB SEC 2 .......................................................................................................................................................................................................................................................
MICRO: -SLIGHT
-NASOLACRIMAL DUCT(S): MUCOSA-SUBACUTE (CHRONIC ACTIVE)/
CHRONIC INFLAMMATION
-MODERATE
-ODONTOPATHY
PROSTATE GLAND .................... ...............................................................................................................................................................
GROSS: -OISCOLORED-AREA(S), SLIGHT
-0.3 X 0.6 CM, GREEN
MICRO: -MODERATE. FOCAL
-ACUTE/SUBACUTE INFLAMMATION
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, LUNGS. NOSE/TURB SEC 1. NOSE/TURB SEC 3. NOSE/TURB SEC 4. PITUITARY GLAND, SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC. "I-** INVASIVE, X- OTHER
BFG 003408
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-96 PAGE: 137
STUDY NUMBER: 964080
ANIMAL NUMBER: 4017 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
538.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYUOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIOIDYMIOES KIDNEYS LIVER
NOSE/TURB SEC 2 NOSE/TURB SEC 3
MICRO: MICRO MICRO:
MICRO: MICRO:
-SLIGHT -MINIMAL.
-MINIMAL, -MINIMAL
-MINIMAL
-MINIMAL
FOCAL FOCAL
NOSE/TURB SEC 4 MICRO: -SLIGHT
TESTES
MICRO: -SLIGHT, FOCAL -SLIGHT
-U: OLIGOSPERMIA
-CORTEX: INFILTRATES,SUBACUTE
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTR1LOBULAR: HYPERTROPHY
-NASOLACRIMAL OUCT(S): INFLAMMATORY CELLS/CELL DEBRIS
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASM1C EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-U: TUBULAR DEGENERATION -REDUCED SPERMATOGENESIS
ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1. PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES, TRACHEA
KEY TO NEOPLASMS; "M-" MALIGNANT. "B-" BENIGN, "S-" METASTATIC.
INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHL0RI0E COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 138
STUDY NUMBER: 964080
ANIMAL NUMBER: 4018 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY OAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 482.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LIVER ......................................................................
MICRO: -MINIMAL. FOCAL -MINIMAL -MINIMAL
MAMMARY GLANDS ................................................. MICRO: -TISSUE MISSING
NOSE/TURB SEC 3 ............................................. MICRO: -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: COAGULATING GL. EPIDIDYMIDES. KIONEYS, LUNGS, NOSE/TURB SEC 1. NOSE/TURB SEC 2. NOSE/TURB SEC 4, PITUITARY GLANO, PROSTATE GLANO, SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S- METASTATIC.
INVASIVE. "X-M OTHER
BFG 003410
*** PATH/TDX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOT IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: 136
STUDY NUMBER: 964080
ANIMAL NUMBER: 4018 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF OEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
482.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER ..................................................................... MICRO: -MINIMAL, FOCAL -MINIMAL -MINIMAL
MAMMARY GLANDS .................................................. MICRO: -TISSUE MISSING
NOSE/TURB SEC 3 .............................................
MICRO: -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NOH-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES, KIDNEYS. LUNGS. NOSE/TURB SEC 1. NOSE/TURB SEC 2, NOSE/TURB SEC 4. PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "1-" INVASIVE. "X-" OTHER
BFG 003411
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED; 29-APR-98 PAGE; 139
STUOY NUMBER: 964080
ANIMAL NUMBER: 4019 DATE OF OEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH; 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: 483.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER NOSE/TURB
SEC 2
MICRO: MICRO:
-MINIMAL, -MINIMAL
-MINIMAL
FOCAL
-EXTRAMEDULLARY HEMATOPOIESIS -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. KIDNEYS, LUNGS. MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 3. NOSE/TURB SEC 4. PITUITARY GLAND. PROSTATE GLAND. SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-'` BENIGN. "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
BFG 003412
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INOIVIOUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 140
STUDY NUMBER: 964080
ANIMAL NUMBER: 4020 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 112
STUDY WEEK OF DEATH; 16
TERMINAL BODY WEIGHT: 527.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS . . . LIVER . . . .
NOSE/TURB SEC 2 NOSE/TURB SEC 4 PITUITARY GLANQ
MICRO: MICRO:
MICRO: MICRO: MICRO:
-MINIMAL -MINIMAL, -MINIMAL -MINIMAL
-MINIMAL -MINIMAL,
FOCAL FOCAL
-PELVIS OILATED -ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY -NASOLACRIMAL OUCT(S): INFLAMMATORY CELLS/CELL DEBRIS
-NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL
-PARS OISTAUS: CYSTS
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVE!) '**
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. LUNGS, MAMMARY GLANDS, NOSE/TURB SEC l, NOSE/TURB SEC 3, PROSTATE GLAND. SEMINAL VESICLES , TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "8-" BENIGN, "S-`* HETASTATIC, "I-" INVASIVE, "X-M OTHER
BFG 003413
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 141
STUDY NUMBER: 964080
ANIMAL NUMBER: 4021 DATE OF DEATH: 04/28/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT: S25.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
EPIDIDYMIDES MICRO: -TISSUE MISSING
LIVER . . . MICRO: -MINIMAL -MINIMAL. FOCAL -MINIMAL
NOSE/TURB SEC 2 MICRO: -SLIGHT
NOSE/TURB SEC 3 MICRO: -MINIMAL
-MINIMAL NOSE/TURB SEC 4
MICRO: -SLIGHT TESTES . . .
MICRO: -TISSUE MISSING
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -NECROSIS.COAGULATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-ODONTOPATHY
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL LUMEN: FREE ERYTHROCYTES
-NASAL LUMEN: FREE ERYTHROCYTES
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, KIDNEYS. LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1. PITUITARY GLAND. PROSTATE GLAND. SEMINAL VESICLES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-M METASTATIC. "I-" INVASIVE, "X-" OTHER
BFG 003414
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: Z9-APR-98 PAGE: 142
STUOY NUMBER: 964060
ANIMAL NUMBER: 4022 DATE OF DEATH: 04/2B/97
SEX: MALE
OOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 112
STUDY WEEK OF DEATH: 16
TERMINAL BODY WEIGHT:
461.2 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS LIVER
NOSE/TURB SEC 1 NOSE/TURB SEC 2 NOSE/TURB SEC 3 PROSTATE GLAND
MICRO: MICRO:
MICRO MICRO MICRO MICRO
-MINIMAL, -MINIMAL, -MINIMAL -MINIMAL
-MINIMAL -MINIMAL -MINIMAL.
FOCAL MULTI-FOCAL
FOCAL
-CORTEX: CYST -NECROSIS,COAGULATION -HEPATOCYTES CENTRIL06ULAR: HYPERTROPHY
-NASOLACRIMAL DUCT{S): FREE ERYTHROCYTES -NASAL LUMEN: FREE'ERYTHROCYTES
-NASALLUMEN: FREE'ERYTHROCYTES
-ALVEOLAR LUMENS: CORPORA AMYLACIA/MiNERALiZED 6RANULES
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED; COAGULATING GL. EPIDIDYMIDES, LUNGS, MAMMARY GLANDS. NOSE/TURB SEC 4, PITUITARY GLAND, SEMINAL VESICLES. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003415
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 143
STUDY NUMBER: 964080
ANIMAL NUMBER: 4023 DATE OF DEATH: 04/29/97
SEX: HALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUOY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
439.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . . . NOSE/TURB SEC 3
MICRO: MICRO:
-MINIMAL. -MINIMAL
-MINIMAL
FOCAL
-MINIMAL
NOSE/TURB SEC 4 .............................. MICRO: -MINIMAL
-MINIMAL
-HEPATOCYTES: BASOPHILIC FOCUS -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASAL MUCOSA (RESPIRATORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHLIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASHIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES 08SERVE0 ***
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. KIDNEYS. LUNGS. MAMMARY GLANOS. NOSE/TURB SEC 1. NOSE/TURB SEC 2. PITUITARY GLANO, PROSTATE GLAND. SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "8-" BENIGN. "S-" METASTATIC. "I-M INVASIVE. MX" OTHER
BFG 003416
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: 144
STUDY NUMBER: 964080
ANIMAL NUMBER: 4024 DATE OF DEATH: 04/29/37
ORGAN NAME
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BOOT WEIGHT:
430.1 GRAMS
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO:
NOSE/TURB SEC 2 MICRO:
N0SE/TUR6 SEC 3 MICRO:
-MINIMAL -MINIMAL
-MINIMAL
-MINIMAL
NOSE/TURB SEC 4 MICRO: -MINIMAL
PITUITARY GLAND MICRO: -MINIMAL, FOCAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACTTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-PARS OISTALIS: CYSTS
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVEO: COAGULATING GL, EPIDIOYMIOES, KIDNEYS, LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1, PROSTATE GLAND. SEMINAL VESICLES,
TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. *'B-m BENIGN, "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED; 29-APR-98 PA6E: 145
STUDY NUMBER: 964000
ANIMAL NUMBER: 4025 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
523.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER ..................................................................... MICRO: -MINIMAL, FOCAL -MINIMAL -MINIMAL
NOSE/TURB SEC 2 ............................................. MICRO: -MINIMAL
NOSE/TURB SEC 4 ............................................. MICRO: -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
:NASOLACRIMAL DUCT(Sj: FREE ERYTHROCYTES*
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-1NTRACYT0PLASM1C EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES. KIDNEYS, LUNGS. MAMMARY GLANDS. NOSE/TURB SEC 1, NOSE/TURB SEC 3, PITUITARY 6LAND, PROSTATE GLAND. SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003418
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 146
STUDY NUMBER: 964080
ANIMAL NUMBER: 4026 DATE OF DEATH: 04/29/97
SEX: MALE
OOSE GROUP: A
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
5S9.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER NOSE/TURB
SEC 3
MICRO: MICRO:
-MINIMAL -MINIMAL
-SLIGHT -MARKED
NOSE/TURB SEC 4 .............................. MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASOLACRIMAL OUCT: LYMPHOIO HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-1NTRACYT0PLASMIC
EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPIASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES, KIDNEYS, LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, PITUITARY GLANO. PROSTATE GLAND. SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: **M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 147
STUDY NUMBER: 964080
ANIMAL NUMBER: 4027 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEOULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BOOY WEIGHT: 487.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS . . .
MICRO; -MINIMAL
LIVER
.... MICRO:'-MINIMAL
-MINIMAL NOSE/TURB SEC 1
MICRO:'-MINIMAL
NOSE/TURB SEC 3 MICRO:'-SLIGHT'
NOSE/TURB SEC 4 MICRO: -MINIMAL
FOCAL FOCAL
-CORTEX: INFILTRATES.SUBACUTE
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASOLACRIMAL DUCT(S): EOSINOPHILIC MATERIAL
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. LUNGS. MAMMARY GLANDS. NOSE/TURB SEC 2, PITUITARY GLAND. PROSTATE GLAND, SEMINAL VESICLES
. TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. ,,B-" BENIGN.
METASTATIC, "I-" INVASIVE. "X-" OTHER
BFG 003420
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 148
STUDY NUMBER: 964080
ANIMAL NUMBER: 4028 DATE OF DEATH; 04/29/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF OEATH: 17
TERMINAL BODY WEIGHT: 46S.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS **" GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER ...................................................................... . MICRO: -MINIMAL, FOCAL -MINIMAL -MINIMAL, FOCAL
NOSE/TURB SEC 4 ............................................. MICRO: -MINIMAL
PROSTATE GLAND .................................................. MICRO: -MINIMAL, FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY -HEPATOCYTES: ACIDOPHILIC FOCUS
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-LYMPHOID CELL INFILTRATE(S)/AGGREGATE(S)
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVED ***
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL, EPIDIDYMIDES, KIDNEYS, LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2, NOSE/TURB SEC 3, PITUITARY GLANO, SEMINAL VESICLES, TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN.
METASTATIC, "I-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-96 PAGE: 149
STUDY NUMBER: 964080
ANIMAL NUMBER: 4029 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
451.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYVOROS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EPIDIDYMIDES .
MICRO:
HISTOPATHOLOGICAL COMMENT: >ONE PRESENT
LIVER
.... MICRO:'-MINIMAL................................................................................. -HEPATOCYTES CENTRI LOBULAR: HYPERTROPHY
MAMMARY GLANDS MICRO:`-TISSUE'HISSING...................................................................................................................................................................................................................
NOSE/TURB SEC 3 MICRO: '-SLIGHT.......................................................................................:NASOLACRIMAL DUCT! LYMPHOiO HYPERPLASiA.....................................
-MINIMAL
-NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
NOSE/TURB SEC 4 MICRO: -SLiGHT.......................................................................................:NASAL ' MUCOSA (OLFACTORY j: 'EPITHELiUM-INTRACYTOPLASMic
EOSINOPHILIC MATERIAL
*** ANIMAL HAS NO GROSS ABNORMALITIES OBSERVEO ***
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES. KIDNEYS. LUNGS. NOSE/TURB SEC l. NOSE/TURB SEC 2. PITUITARY GLAND. PROSTATE GLANO, SEMINAL VESICLES, TESTES, TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003422
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-6ENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: ISO
STUDY NUMBER: 964960
ANIMAL NUMBER: 4030 DATE OF DEATH: 04/29/97
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 113
STUDY WEEK OF DEATH: 17
TERMINAL BODY WEIGHT:
492.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EARS
GROSS:
MICRO:
GROSS/MICRO CDRR MICRO
LIVER MICRO
N0SE/TUR8 NDSE/TURB NOSE/TURB
SEC 1 SEC 2 SEC 3
MICRO: MICRO: MICRO:
NOSE/TURB SEC 4 MICRO
'SWOLLEN. MODERATE 'DISCOLORED -MODERATE -MODERATE
HISTOPATHOLOGICAL COMMENT:
-MINIMAL -MINIMAL
-MINIMAL
-MINIMAL
-MINIMAL
-MINIMAL
-BOTH -BOTH: RED -SUBACUTE (CHRONIC ACTIVE)/CHRONIC
-NECROSIS CARTILAGE
INFLAMMATION
>EARS: SWOLLEN,DISCOLORED/SUBA.CHRONIC INFLAMMATION
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZGNAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-NASOLACRIMAL DUCT(S): EOSINOPHILIC MATERIAL
-NASOLACRIMAL OUCT(S): INFLAMMATORY CELLS/CELL DEBRIS
-NASAL MUCOSA (OLFACTORY): EPITHEL1UM-INTRACYT0PLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHEL1UM-INTRACYT0PLASMIC EOSINOPHILIC MATERIAL
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: COAGULATING GL. EPIDIDYMIDES, KIDNEYS, LUNGS, MAMMARY GLANDS, PITUITARY GLAND, PROSTATE GLAND, SEMINAL VESICLES. TESTES. TRACHEA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC. MI-" INVASIVE. "X-M OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 151
STUDY NUMBER: 964060
ANIMAL NUMBER: 1501 DATE OF OEATH: 05/27/97
SEX: FEMALE
DOSE GROUP: I
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 310.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GROSS/MICRO CORR ...........................................................................................................................................................................................................
MICRO:
H1STOPATHOLOGICAL COMMENT: >KIDNEY {R): DILATATION/PELVIS OILATED
KIDNEYS ...............................................................................................................................................................................................................................
GROSS: -DILATATION.SEVERE
-RIGHT
MICRO: -MARKED
-PELVIS DILATED
-MODERATE
-PYELONEPHRITIS,SUBACUTE
LIVER
...................................................................... MICRO: -MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
LUNGS
...................................................................... MICRO: -MINIMAL,FOCAL
-PULMONARY VESSELS: MINERAL DEPOSIT(S)
NOSE/TURB SEC 3 ..............................
MICRO: -MINIMAL -MINIMAL
-NASOLACRIMAL OUCT: LYMPHOID HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASHIC
EOSINOPHILIC MATERIAL
NOSE/TURB SEC 4 .......................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASHIC
EOSINOPHILIC MATERIAL
-MINIMAL
-NASAL MUCOSA (RESPIRATORY): EPITHELIUM-INTRACYTOPLASHIC
EOSINOPHLiC MATERIAL
UTERUS
GROSS: -IMPLANT SCARS - PRESENT
-LEFT: 6; RIGHT: 0
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, OVARIES, OVIOUCTS/FALOP T. PITUITARY GLANO. TRACHEA. UTERUS. VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-'* INVASIVE, "X-` OTHER
03
a
003424
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 152
STUDY NUMBER: 964080
ANIMAL NUMBER: 1502 OATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY OAY OF OEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
262.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
NOSE/TURB SEC 3 .................................
MICRO: -MINIMAL
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA
-MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
-MINIMAL
-NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
-SLIGHT
-NASAL LUMEN: FREE ERYTHROCYTES
NOSE/TURB SEC 4 .................................
MICRO: -SLIGHT
-NASAL LUMEN: FREE ERYTHROCYTES
-MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
UTERUS .............................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 6; LEFT: 6
MICRO: -SLIGHT
-ENDOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS, LIVER. LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, OVARIES, OVIDUCTS/FALOP T, PITUITARY GLAND, TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT.
BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003425
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 153
STUDY NUMBER: 964080
ANIMAL NUMBER: 1503 DATE OF OEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
297.8 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER MICRO
NOSE/TURB SEC 3 MICRO
NOSE/TURB SEC 4 MICRO
-MINIMAL -slIght
-MINIMAL
PITUITARY GLAND MICRO:
UTERUS GROSS: MICRO:
-MINIMAL. FOCAL
-IMPLANT SCARS -MINIMAL. FOCAL
PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -NASOLACRIMAL DUCT: LYMPHOID`HYPERPLASiA*
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASM 1C EOSINOPHILIC MATERIAL
-PARS INTERMEDIA: CYST(S)
-RIGHT: 12; LEFT: 3 -ENDOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS, LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2. OVARIES. OVIDUCTS/FALOP T, TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003426
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INOIVIOUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 1S4
STUDY NUMBER: 964080
ANIMAL NUMBER: 1504 OATE OF OCATH: 05/28/97
ORGAN NAME
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY OAY OF OEATH: 142
STUDY WEEK OF DEATH: ZI
TERMINAL BODY MIGHT: 3Q5.9 GRAMS
* * * PATHOLOGY KEYWOROS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LIVER . . . . NOSE/TURB SEC 3
MICRO: MICRO:
-MINIMAL, -MINIMAL
FOCAL
-MINIMAL
NOSE/TURB SEC 4 ........................... MICRO: -SLIGHT
UTERUS
....................................................................................................... GROSS: -IMPLANT SCARS - PRESENT MICRO: -MINIMAL. FOCAL
-ACUTE/SU8ACUTE INFLAMMATION
-NASAL MUCOSA (RESPIRATORY): EPITHELIUM-INTRACYTOPLASMIC EOS1N0PHLIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-RIGHT: 6; LEFT: 7 -ENDOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS. LUNGS, MAMMARY GLAN05, NOSE/TURB SEC 1, NOSE/TURB SEC 2. OVARIES, OVIOUCTS/FALOP T. PITUITARY GLAND. TRACHEA. VAGINA
KEY TO NEOPLASMS: "M-*` MALIGNANT. "B-" BENIGN,
METASTATIC, "1-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 155
STUDY NUMBER: 964080
ANIMAL NUMBER: 1505 DATE OF DEATH: 05/28/97
ORGAN NAME
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCKEOULEO, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 142
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
284.7 GRAMS
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
............................................................................ MICRO: -MINIMAL, FOCAL -MINIMAL -MINIMAL, FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NECROSIS,COAGULATION
NOSE/TURB SEC 3 ................................................. MICRO: -MINIMAL
-MINIMAL -MINIMAL
-NASAL MUCOSA (RESPIRATORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHLIC MATERIAL
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
NOSE/TURB SEC 4 ........................................................................................................................................................................................................................................................................
MICRO: -SLIGHT
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
UTERUS
.............................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 9; LEFT: 5
MICRO: -MINIMAL, FOCAL
-ENDOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: KIDNEYS, LUNGS. MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 2. OVARIES, OVIDUCTS/FALOP T. PITUITARY GLAND,
TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-'* MALIGNANT. "B-" BENIGN, "S-" METASTATIC, "I-H INVASIVE. "X-" OTHER
o
8ltfOO
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 156
STUDY NUMBER: 964080
ANIMAL NUMBER: IS06 DATE OF DEATH: 05/29/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 143
STUOY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
305.7 GRAMS
ORGAN NAME
* * * PATH0L06Y KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS MICRO: -MINIMAL, FOCAL
LIVER MICRO -MINIMAL
NOSE/TURB SEC 2 MICRO -MINIMAL
NOSE/TURB SEC 3 MICRO -MINIMAL
NOSE/TURB SEC 4 MICRO -MINIMAL
UTERUS
GROSS: -IMPLANT SCARS - PRESENT MICRO: -MINIMAL, FOCAL
-CORTEX: INFILTRATES,SUBACUTE
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASOLACRIMAL DUCT(S)INFLAMMATORY CELLS/CELL DEBRIS -NASOLACRIMAL DUCT: LYMPHoiDHYPERPLASW.................................
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYT0PLASH1C EOSINOPHILIC MATERIAL
-RIGHT: 5; LEFT: 8 -ENDOMETRIUM: BROUN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1, OVARIES. OVIOUCTS/FALOP T, PITUITARY GLAND, TRACHEA. VAGINA
KEY TO NEOPLASMS: "M-`* MALIGNANT, "B-" BENIGN. *'S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
BFG 003429
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 157
STUDY NUMBER: 964080
ANIMAL NUMBER: 1507 OATE OF DEATH: 06/03/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 148
STUOY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT:
298.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC F1N0INGS
LIVER LUNGS NOSE/TURB SEC NOSE/TURB SEC
MICRO:
MICRO 3
MICRO 4
MICRO
-MINIMAL -MINIMAL -SLiGHT*
-MINIMAL
UTERUS
GROSS: -IMPLANT SCARS - PRESENT MICRO: -SLIGHT. FOCAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NQN-ZONAL)
-PERIVASCULAR: EDEMA -NASOLACRIMAL DUCT: LYMPHoiOHYPERPLAsiA'
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASM IC EOSINOPHILIC MATERIAL
-RIGHT: B; LEFT: 5 -ENDOMETRIUM: HEMORRHAGE(S)
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS. MAMMARY GLANDS. NOSE/TURB SEC 1, NOSE/TURB SEC 2. OVARIES. OVIDUCTS/FALOP T, PITUITARY GLAND. TRACHEA.
VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003430
ANIMAL NUMBER: 1508 DATE OF DEATH: 05/27/97
ORGAN NAME
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-QENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 158
STUDY NUMBER: 964080
SEX; FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
298.6 GRAMS
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER LUNGS
.. .. MICRO: -MINIMAL, FOCAL
.. .. MICRO:'-MINIMAL,'FOCAL
NOSE/TURB SEC 3 MICRO: -MINIMAL
-MINIMAL
-MINIMAL, FOCAL
NOSE/TURB SEC 4 MICRO: -MINIMAL
UTERUS
....................................................................................................... GROSS: -IMPLANT SCARS - PRESENT MICRO: -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION
-PULMONARY VESSELS: MINERAL DEPOSIT(S)
-NASAL MUCOSA (RESPIRATORY): EPITHELIUM-INTRACYTOPLASMIC E0SIN0PHL1C MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUH-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): BASOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUH-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-RIGHT: B: LEFT: 7 -ENDOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS, MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, OVARIES. OVIDUCTS/FALOP T, PITUITARY GLANO, TRACHEA,
VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, H0-M BENIGN,
METASTATIC, ''I-'* INVASIVE, "X-' OTHER
BFG 003431
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 159
STUDY NUMBER: 964080
ANIMAL NUMBER: 1509 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL 80DY WEIGHT:
309.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS ......................................................
LIVER
MICRO: -MINIMAL ............................................................
MICRO: -MINIMAL
NOSE/TUR0 SEC 3
-MINIMAL .................................
MICRO: -MINIMAL
FOCAL FOCAL
NOSE/TURB SEC 4 ........................... MICRO: -SLIGHT
UTERUS
GROSS: -IMPLANT SCARS - NOT PRESENT
-CORTEX: INFILTRATES.SUBACUTE
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED:
LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2, OVARIES. OVIDUCTS/FALOP T, PITUITARY GLAND, TRACHEA. UTERUS, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
BFG 003432
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 160
STUDY NUMBER: 964080
ANIMAL NUMBER: 1510 DATE OF DEATH: 05/28/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 142
STUDY WEEK OF DEATH: 21
TERMINAL BOOY WEIGHT: 277.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EARS .................................................................................... GROSS: -SWOLLEN, SLIGHT -DISCOLORED, SLIGHT
MICRO: -MODERATE -MINIMAL, FOCAL
GROSS/MICRO CORR MICRO:................................... HISTOPATHOLOGICAL
COMMENT:
-BOTH -BOTH: RED -SUBACUTE {CHRONIC ACTIVEJ/CHRONIC INFLAMMATION -NECROSIS CARTILAGE
>EARS: SWOLLEN.OISCOLORED/INFLAMMATION SUBACUTE
KIDNEYS
.......................................................................................................................................................................................................................................................
MICRO: -MINIMAL, HULTI-FOCAl
-CORTEX: INFILTRATES.SUBACUTE
LIVER
...................................................................... MICRO: -MINIMAL, FOCAL
-MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
NOSE/TURB SEC 2 ............................................. MICRO: -MINIMAL. FOCAL
-VOMERONASAL ORGAN: FREE ERYTHROCYTES
NOSE/TURB SEC 3 ................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASOLACRIMAL DUCT: LYMPHOIO HYPERPLASIA
UTERUS ........................................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 12; LEFT: 2
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: LUNGS. MAMMARY GLANOS, NOSE/TURB SEC 1. NOSE/TURB SEC 4, OVARIES, OVIDUCTS/FALOP T, PITUITARY GLAND. TRACHEA, UTERUS,
VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN,
METASTATIC. "I-" INVASIVE, "X-M OTHER
BFG 003433
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 161
STUDY NUMBER: 964080
ANIMAL NUMBER: 1511 OATE OF DEATH: 06/03/97
ORGAN NAME
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 146
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT:
315.8 GRAMS
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO: -MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (N0N-20NAL)
NOSE/TURB SEC 3 MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
NOSE/TURB SEC 4 .........................................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACVTOPLASM IC
EOSINOPHILIC MATERIAL
UTERUS ........................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 6; LEFT: 9
MICRO: -SLIGHT. MULTI-FOCAL
-MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS, LUNGS, MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 2. OVARIES, OVIOUCTS/FALOP T, PITUITARY GLAND,
TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003434
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 162
STUDY NUMBER: 9G40B0
ANIMAL NUMBER: 1512 OATE OF DEATH: 05/27/97
SEX: FEMALE
DOSE GROUP: I
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
276.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GROSS/MICRO CORR ........................................................................................................................................................................................................................................................................................................
MICRO:
HISTOPATHOLOGICAL COMMENT: >PANCREAS: DISCOLORED/NMC
THYMUS: DISCOLORED/CONGESTION
KIDNEYS ..............................................................................................................................................................................................................................................................................................................................
MICRO: -MINIMAL, FOCAL
-CORTEX: CYST
NOSE/TURB SEC 3 .........................................................................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
PANCREAS ..............................................................................................................................................................................................................................................................................................................................
GROSS: -DISCOLORED. SLIGHT
-REO
THYMUS ...................................................................................................................................................................................................................................................................................................................................
GROSS: -DISCOLORED, SLIGHT
-REO
MICRO: -MINIMAL
-CONGESTION
UTERUS ...................................................................................................................................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS -PRESENT
-RIGHT: 4; LEFT: 11
MICRO: -MINIMAL. FOCAL
-ENDOMETRIUM:BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: LIVER, LUNGS, MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 2, NOSE/TURB SEC 4, OVARIES. OVIOUCTS/FALOP T, PANCREAS, PITUITARY GLAND. TRACHEA. VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-*' BENIGN,
METASTATIC. "I-" INVASIVE. "X-H OTHER
smoo oia
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 163
STUDY NUMBER: 964080
ANIMAL NUMBER: 1513 DATE OF DEATH: 05/28/9?
SEX: FEMALE
OOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 142
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
289.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
KIDNEYS
... MICRO:
NOSE/TURB SEC 2 MICRO:
NOSE/TURB SEC 3 MICRO:
UTERUS . . . . GROSS: MICRO:
-MINIMAL. FOCAL -MINIMAL
-MINIMAL
-SLIGHT
-IMPLANT SCARS -MINIMAL. FOCAL
PRESENT
-MEOULLA: CYST -PELVIS DILATED
-NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
-NASOLACRIMAL DUCT: LYMPHOIO HYPERPLASIA
-RIGHT: 4; LEFT: 0 -ENDOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: LIVER. LUNGS. MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 4. OVARIES, OVIDUCTS/FALOP T. PITUITARY GLAND, TRACHEA.
VAGINA
KEY TO NEOPLASMS: "M-H MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE. "X" OTHER
BFG 003436
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-9B PAGE: 164
STUDY NUMBER: 964080
ANIMAL NUMBER: 1514 DATE OF DEATH: 05/27/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF OEATH: 21
TERMINAL BODY WEIGHT:
306.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS . . .
MICRO: -MINIMAL, MULTI-FOCAL
LIVER
.... MICRO: -MINIMAL, FOCAL......................
NOSE/TURB SEC 2 MICRO: -MINIMAL
NOSE/TURB SEC 3 MICRO:'-MINIMAL
-SLIGHT -MINIMAL
-SLIGHT NOSE/TURB SEC 4
MICRO:`-MINIMAL
UTERUS
-MINIMAL, FOCAL ....
GROSS:'-iMPLANT SCARS - PRESENT
MICRO: -MINIMAL. FOCAL
-CALCIFIC GRANULES
-ACUTE/SUBACUTE INFLAMMATION
-NASOLACRIMAL OUCT(S): FREE ERYTHROCYTES
-NASAL MUCOSA (RESPIRATORY): EPITHELIUM-INTRACYTOPLASMIC E0S1N0PHLIC MATERIAL
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL -NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (RESPIRATORY): BASOPHILIC MATERIAL
-RIGHT: 7; LEFT: 6 -ENDOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: LUNGS. MAMMARY 6LAN0S. NOSE/TURB SEC 1, OVARIES. OVIDUCTS/FALOP T. PITUITARY GLAND. TRACHEA. VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003437
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 16S
STUDY NUMBER: 964080
ANIMAL NUMBER: 1515 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
302.8 GRAMS
ORGAN NAME
*** PATHOLOGY KEYUOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
EARS
GROSS: -SWOLLEN, MODERATE
-BOTH
-DISCOLOREO, MODERATE
-BOTH: RED
MICRO: -MODERATE
-SUBACUTE (CHRONIC ACT!VE)/CHRGNIC INFLAMMATION
-MINIMAL, FOCAL
-NECROSIS CARTILAGE
GROSS/MICRO CORR ...................................................................................................................................................................................................................................................................
MICRO:
HISTOPATHOLOGICAL COMMENT: >EARS: SWOLLEN,DISCOLORED/SUBA.CHRONIC INFLAMMATION
LIVER
MICRO: -MINIMAL. FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
NOSE/TURB SEC 3 .........................................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASOLACRIMAL DUCT; LYMPHOID HYPERPLASIA
-MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
NOSE/TURB SEC 4 .........................................................................................................................................................................................................................................................................
MICRO: -SLIGHT
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYT0PLASM1C
EOSINOPHILIC MATERIAL
UTERUS ..............................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 3; LEFT: 9
MICRO: -MINIMAL, FOCAL
-ENDOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS, LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, OVARIES, OVIOUCTS/FALOP T, PITUITARY 6LAND, TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-** INVASIVE, "X-" OTHER
BFG 003438
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 166
STUDY NUMBER: 964080
ANIMAL NUMBER: 1516 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 144
STUDY WEEK OF OEATH: 21
TERMINAL BODY WEIGHT:
286.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER MICRO
LUNGS MICRO
N0SE/TUR8 SEC 3 MICRO
-MINIMAL. FOCAL -TISSUE MISSING -MINIMAL
NOSE/TURB SEC 4 MICRO: -SLIGHT
UTERUS
GROSS: -IMPLANT SCARS - PRESENT MICRO: -SLIGHT. FOCAL
-ACUTE/SUBACUTE INFLAMMATION
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASHIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-RIGHT: 8; LEFT: 6 -MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS, HAMMARY GLANOS. NOSE/TURB SEC 1. NOSE/TURB SEC 2, OVARIES, 0V1DUCTS/FAL0P T. PITUITARY GLANO. TRACHEA,
VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN, "S-" METASTATIC, "1-'' INVASIVE. "X-" OTHER
BFG 003439
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 167
STUDY NUMBER: 964080
ANIMAL NUMBER: 1517 DATE OF DEATH: 05/28/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 142
STUDY WEEK OF DEATH: 21
TERMINAL BOOT WEIGHT:
296.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COHMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . . . MICRO:
NOSE/TURB SEC 2 MICRO:
NOSE/TURB SEC 3 MICRO:
-MINIMAL,
-MINIMAL,
-SLIGHT -MINIMAL
FOCAL FOCAL
NOSE/TURB SEC 4 MICRO: -MINIMAL
UTERUS .... GROSS:* - IMPLANT SCARS - PRESENT
-ACUTE/SUBACUTE INFLAMMATION -VOMERONASAL'ORGAN: FREE'ERYTHROCYTES
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-RIGHT: 5; LEFT: 8
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS. LUNGS, MAMMARY GLANOS, NOSE/TURB SEC 1, OVARIES, OVIDUCTS/FALOP T, PITUITARY GLAND, TRACHEA, UTERUS. VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE. "X-M OTHER
BFG 003440
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 168
STUOY NUMBER: 964080
ANIMAL NUMBER: 1516 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
284.8 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
NOSE/TURB SEC 2 ............................................. MICRO: -MINIMAL, FOCAL
-VOMORONASAL ORGAN: EOSINOPHILIC MATERIAL
NOSE/TURB SEC 4 ............................................. MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASHIC EOSINOPHILIC MATERIAL
UTERUS ........................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 5; LEFT: 8
MICRO: -MINIMAL. FOCAL
-MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: KIDNEYS, LIVER. LUNGS, MAMMARY GLANDS. N0SE/TUR8 SEC 1, NOSE/TURB SEC 3, OVARIES, OVIDUCTS/FALOP T. PITUITARY GLAND,
TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "l-*' INVASIVE, "X-" OTHER
BFG 003441
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 169
STUDY NUMBER: 964060
ANIMAL NUMBER: 1519 DATE OF DEATH: 05/23/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: UNSCHEDULED (A)
STUDY DAY OF DEATH: 13?
STUDY WEEK OF DEATH: 20
TERMINAL BODY WEIGHT:
320.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GROSS/MICRO CORR MICRO:...................................... HISTOPATHOLOGicAL COMMENT: >TRACHEA; FLUID/NMC
KIDNEYS
................................................................................................. MICRO: -MINIMAL, FOCAL
LIVER LUNGS
....................................................................................................... MICRO: -MINIMAL. FOCAL
...................................................................................................... GROSS: -FLUIO FILLED. SLIGHT
MICRO: -MINIMAL
-MODERATE NOSE/TURB SEC 1 ............................................................................
MICRO: -MINIMAL -SLIGHT
NOSE/TURB SEC 2 ............................................................................ MICRO: -MODERATE
-MINIMAL
-SLIGHT
NOSE/TURB SEC 3 ............................................................................ MICRO: -MODERATE
TRACHEA
................................................................................................. GROSS: -FLUID. SLIGHT
UTERUS ....................................................................................................... GROSS: -IMPLANT SCARS - PRESENT
MICRO: -SLIGHT. FOCAL
LUNGS: FLUID FIUEO/HEMORRHAGE ALVEOLAR
-CORTEX: INFILTRATES,SUBACUTE
-ACUTE/SUBACUTE INFLAMMATION
-ALL LOBES -PERIVASCULAR: EDEMA -HEMORRHAGE ALVEOLAR
-VQMORONASAL ORGAN: FREE ERYTHROCYTES -NASAL LUMEN: FREE ERYTHROCYTES
-NASAL LUMEN: FREE ERYTHROCYTES -VOMERONASAL ORGAN: FREE ERYTHROCYTES -NASOLACRIMAL DUCT(S): FREE ERYTHROCYTES
-NASAL LUMEN: FREE ERYTHROCYTES
-LUMEN: WHITE. FROTHY
-RIGHT: 8; LEFT: 9 -MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: MAMMARY GLANOS, NOSE/TURB SEC 4, OVARIES. OVIDUCTS/FALOP T, PITUITARY GLAND, TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, ''B-'' BENIGN, MS-" METASTATIC, **!-" INVASIVE. "X-" OTHER
BpG 003442
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE; 170
STUDY NUMBER; 964080
ANIMAL NUMBER: 1520 DATE OF DEATH: 05/27/97
ORGAN NAME
SEX; FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
271.2 GRAMS
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GROSS/MICRO CORR MICRO:
NOSE/TURB SEC 3 MICRO:
NOSE/TURB SEC 4 MICRO-
PITUITARY GLAND MICRO:
THYMUS .... GROSS; MICRO:
UTERUS .... GROSS:
-SLIGHT -MINIMAL
H1STOPATHOLOGICAL COMMENT:
-MINIMAL
-DISCOLORED, SLIGHT -MINIMAL
-IMPLANT SCARS - PRESENT
>THYMUS: DISCOLORED/CONGESTION
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA
-NASAL MUCOSA (OLFACTORY}: EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-PARS OISTALIS: CYSTS
-RED -CONGESTION
-RIGHT: 5; LEFT: 6
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS. LIVER, LUNGS, MAMMARY GLANOS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, OVARIES, OVIDUCTS/FALOP T, TRACHEA. UTERUS,
VAGINA
KEY TO NEOPLASMS; "M-" MALIGNANT, MB-" BENIGN, "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
BFG 003443
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 171
STUDY NUMBER: 964060
ANIMAL NUMBER: 1521 DATE OF DEATH: 06/05/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 150
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT:
279.3 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . . . MICRO:
NOSE/TURB SEC 2 MICRO:
NOSE/TURB SEC 4 MICRO:
-MINIMAL, -SLIGHT -MINIMAL
FOCAL
UTERUS
GROSS: -IMPLANT SCARS PRESENT MICRO: -MINIMAL. FOCAL
ACUTE/SUBACUTE INFLAMMATION -NASOLACRIMAL OUCT(Sj:'FREE ERYTHROCYTES'
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-RIGHT: 11; LEFT: 4 -MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIONEYS, LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 3, OVARIES. OV[DUCTS/FALOP T, PITUITARY GLAND. TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003444
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 172
STUDY NUMBER: 964080
ANIMAL NUMBER: 1522 DATE OF DEATH: 05/27/97
SEX: FEMALE
OOSE GROUP: 1
SACRIFICE STATUS: SCHEDULEO. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
283.3 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREC-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . . . MICRO:
NOSE/TURB SEC 2 MICRO:
NOSE/TURB SEC 3 MICRO:
-MINIMAL, -MINIMAL -MINIMAL
FOCAL
NOSE/TURB SEC 4 ............................ MICRO: -SLIGHT
UTERUS
....................................................................................................... GROSS: -IMPLANT SCARS - PRESENT MICRO: -MINIMAL. FOCAL
-ACUTE/SUBACUTE INFLAMMATION
-NASOLACRIMAL OUCT(S): INFLAMMATORY CELLS/CELL DEBRIS
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-RIGHT: 5; LEFT: 9 -MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVEO: KIDNEYS, LUNGS. MAMMARY GLANDS. NOSE/TURB SEC 1. OVARIES. OVIDUCTS/FALOP T. PITUITARY GLAND. TRACHEA. VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, MS-" METASTATIC. "I-" INVASIVE, MX-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 173
STUDY NUMBER: 964080
ANIMAL NUMBER: 1523 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 358.2 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
KIDNEYS . . . MICRO:
LIVER .... MICRO:
NOSE/TURB SEC 2 MICRO:
NOSE/TURB SEC 4 MICRO:
-MINIMAL. -MINIMAL, -SLIGHT -MINIMAL
MULTI FOCAL
UTERUS
GROSS: -IMPLANT SCARS MICRO: -MINIMAL, FOCAL
-INTERSTITIAL NEPHRITIS SUBACUTE -ACUTE/SUBACLITE INFLAMMATION...................................................................... -NASOLACRIMAL DUCT(Sj:'FREE ERYTHROCYTES...................................... -.N....A..S...A...L.....M...U...C...O...S..A......(..O...L..F..A...C...T..O...R...Y......... EPITHELiuM-iNTRACYTOPLASMic'
EOSINOPHILIC MATERIAL
-NYQNETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 3, OVARIES, OVIDUCTS/FALOP T. PITUITARY GLAND. TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN.
METASTATIC. "I-" INVASIVE, "X-M OTHER
BFG 003446
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE CQMB1NE0 INHALATION TWQ-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-9B PAGE: 174
STUDY NUMBER: 964080
ANIMAL NUMBER: 1524 DATE OF DEATH: 05/29/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 143
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
292.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER LUNGS
UTERUS
MICRO: -MINIMAL, FOCAL
MICRO: -MINIMAL, FOCAL -SLIGHT -SLIGHT. FOCAL
GROSS: -IMPLANT SCARS - PRESENT MICRO: -MOOERATE, FOCAL
-ACUTE/SUBACUTE INFLAMMATION
-PULMONARY VESSELS: MINERAL OEPOSIT(S) -HEMORRHAGE ALVEOLAR -PERIBRONCHIAL: LYMPHOCYTIC HYPERPLASIA
-RIGHT: 5; LEFT: 8 -MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS. MAMMARY GLANDS. N0SE/TUR8 SEC 1. NOSE/TURB SEC 2. NOSE/TURB SEC 3. NOSE/TURB SEC 4. OVARIES, OVIDUCTS/FALOP T
. PITUITARY GLAND. TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "IINVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 175
STUDY NUMBER: 964080
ANIMAL NUMBER: 1525 DATE OF DEATH: 05/28/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULEO, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 142
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
294.3 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS
MICRO:
LUNGS
MICRO
NOSE/TURB SEC 2
MICRO
N0SE/TUR8 SEC 4
MICRO
-MINIMAL, FOCAL -SLIGHT. FOCAL -MINIMAL -MINIMAL
UTERUS
GROSS: -IMPLANT SCARS - PRESENT MICRO: -MINIMAL, FOCAL
-DILATED TUBULES
-PERIBRONCHIAL: LYMPHOCYTIC HYPERPLASIA
-NASOLACRIMAL DUCT(S): INFLAMMATORY CELLS/CELL 0E6RIS
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-RIGHT: 10; LEFT: 6 -MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: LIVER, MAMMARY GLANDS. NOSE/TURB SEC 1. NOSE/TURB SEC 3, OVARIES, OVIDUCTS/FALOP T. PITUITARY GLAND, TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-** BENIGN. "S-" METASTATIC. "1-" INVASIVE. "X-" OTHER
BFG 003448
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 176
STUDY NUMBER: 964060
ANIMAL NUMBER: 1526 DATE OF OEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 144
STUOY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 277.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL, FOCAL -MINIMAL, FOCAL
GROSS: -IMPLANT SCARS - PRESENT MICRO: -SLIGHT, FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-RIGHT: 9; LEFT: 2 -MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVEO: KIDNEYS, LUNGS. MAMMARY GLANOS. NOSE/TURB SEC I, NOSE/TUR0 SEC 2. NDSE/TURB SEC 3. NOSE/TURB SEC 4. OVARIES,
QVIOUCTS/FALOP T. PITUITARY GLAND. TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN.
METASTATIC. "I-" INVASIVE, "X-" OTHER
ANIMAL NUMBER: 1527 DATE OF OEATH: 05/30/97
ORGAN NAME
*** PATH/TQX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 177
STUDY NUMBER: 964080
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
273.5 GRAMS
*** PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER
MICRO:
NOSE/TURB SEC 3 MICRO:
-MINIMAL. -MINIMAL.
-SLIGHT -MINIMAL
FOCAL FOCAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA -NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC
EOSINOPHILIC MATERIAL
NOSE/TURB SEC 4 ................................. MICRO: -MINIMAL
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
UTERUS
..............................................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS - NOT PRESENT
MICRO: -MINIMAL, FOCAL
-MYOMETRIUM: BROWN PIGMENT
-MINIMAL
-ENOOMETRIUM: INFILTRATES SUBACUTE
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS, LUNGS. MAMMARY GLANDS, NOSE/TURB SEC 1. NOSE/TURB SEC 2. OVARIES. OVIDUCTS/FALOP T. PITUITARY GLAND,
TRACHEA, VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003450
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 178
STUDY NUMBER: 964080
ANIMAL NUMBER: 1528 DATE OF OEATH: 06/04/97
ORGAN NAME
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY OAY OF OEATH: 149
STUOY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 299.8 GRAMS
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS f HISTOPATHOLOGIC FINDINGS
GROSS/MICRO CORR ..............................................................................................................................................................
MICRO:
HIST0PATH0L0G1CAL COMMENT: >LUNGS: NODULES/NMC
LUNGS
.............................................................................................. GROSS: -NO0ULE(S)/MASS(ES)
-NODULES. ALL LOBES: 0.1 - 0.3 CM DIA, TAN
MICRO: -MINIMAL, FOCAL
-PULMONARY VESSELS: MINERAL OEPOSIT(S)
-MINIMAL -SLIGHT. FOCAL
-PERIVASCULAR: EDEMA -PERIBRONCHIAL: LYMPHOCYTIC HYPERPLASIA
NOSE/TURB SEC 1 ...................................................................... MICRO: -MINIMAL
-NASAL LUMEN: EXUDATE
NOSE/TURB SEC 2 ...................................................................... MICRO: -MOOERATE
-NASOLACRIMAL DUCT(S):`MUCOSA-SUBACUTE`{CHRONIC ACTIVE)/ CHRONIC INFLAMMATION
-SLIGHT
-ODONTOPATHY
-SLIGHT
-NASOLACRIMAL DUCT: EXUDATE
NOSE/TURB SEC 3 ......................................................................
MICRO: -SLIGHT
-NASOLACRIMAL OUCT: LYMPHOIO HYPERPLASIA
UTERUS
.............................................................................................. GROSS: -IMPLANT SCARS - PRESENT MICRO: -SLIGHT. FOCAL
-RIGHT: 3; LEFT: 6 -MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS. LIVER. MAMMARY GLANDS. NOSE/TURB SEC 4. OVARIES, OVIDUCTS/FALOP T, PITUITARY GLAND. TRACHEA. VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003451
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 179
STUDY NUMBER: 964080
ANIMAL NUMBER: 1529 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: J
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY OAY OF OEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
276.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GROSS/MICRO CORR . .
MICRO:
HISTOPATHOLOGICAL COMMENT: >KIDNEYS: DILATATION/PYELONEPHRITIS SUBA
KIDNEYS ............................
GROSS: -DILATATION, MOOERATE
-BOTH PELVES
MICRO: -MARKED
-PELVIS OILATED
-MODERATE
-PYELONEPHRITIS. SUBACUTE
LIVER .................................
MICRO: -SLIGHT. FOCAL
-ACUTE/SUBACUTE INFLAMMATION
NOSE/TURB SEC 3 ...................................................................................................................................................................................................................................
MICRO: -MINIMAL
-NASOLACRIMAL DUCT: LYMPHOID HYPERPLASIA
UTERUS....................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 8; LEFT: 4
MICRO: -SLIGHT, FOCAL
-MYOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAO NO MICROSCOPIC ABNORMALITIES OBSERVED: LUNGS, MAMMARY GLANDS, NOSE/TURB SEC 1, NOSE/TURB SEC 2, NOSE/TURB SEC 4. OVARIES. OVIDUCTS/FALOP T, PITUITARY GLAND, TRACHEA. VAGINA
KEY TO NEOPLASMS: "M-" MALIGNANT, "0-" BENIGN, "S-" METASTATIC, "1-" INVASIVE. "X-" OTHER
BFG 003452
ANIMAL NUMBER: 1530 DATE OF DEATH: 05/29/97
ORGAN NAME
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 180
STUDY NUMBER: 964080
SEX: FEMALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF DEATH: 143
STUDY WEEK OF OEATH: 21
TERMINAL 800Y WEIGHT:
261.6 GRAMS
* * * PATHOLOGY KEYWOROS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HIST0PATH0L06IC FINDINGS
LIVER LUNGS NOSE/TURB NQSE/TUR8 NOSE/TURB
SEC 2 SEC 3 SEC 4
MICRO: MICRO MICRO MICRO MICRO
-MINIMAL, FOCAL -SLIGHT. FOCAL -MINIMAL, FOCAL -MINIMAL -MINIMAL
UTERUS
GROSS: -IMPLANT SCARS - PRESENT MICRO: -MINIMAL, FOCAL
-ACUTE/SUBACUTE INFLAMMATION
-PNEUMONITIS INTERSTITIAL SUBACUTE -VOHORONASAL ORGAN: EOSINOPHilic MATERIAL
-NASOLACRIMAL OUCT: LYMPHOID HYPERPLASIA
-NASAL MUCOSA (OLFACTORY): EPITHELIUM-INTRACYTOPLASMIC EOSINOPHILIC MATERIAL
-RIGHT: 3; LEFT: 8 -ENDOMETRIUM: BROWN PIGMENT
THE FOLLOWING TISSUES HAD NO MICROSCOPIC ABNORMALITIES OBSERVED: KIDNEYS. MAMMARY GLANDS. NOSE/TURB SEC 1. OVARIES, OYIOUCTS/FALOP T. PITUITARY GLAND, TRACHEA. VAGINA
KEY TO NEOPLASMS: "N-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BFG 003453
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TVO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 181
STUDY NUMBER: 9640&0
ANIMAL NUMBER: 2501 DATE OF OEATH: 05/29/97
ORGAN NAME
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF OEATH: 143
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 271.9 GRAMS
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
UTERUS . .
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 13; LEFT: 4
*** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
BFG 003454
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INOIVIOUAl ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 182
STUDY NUMBER: 964080
ANIMAL NUMBER: 2S02 DATE OF DEATH: OS/27/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUOY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 273.8 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LIVER UTERUS
...................................... MICRO: -MINIMAL, FOCAL -MINIMAL
................................ GROSS: -IMPLANT SCARS -
NOT
PRESENT
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NQN-ZONAL)
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-m BENIGN. "S-" METASTATIC, "1-" INVASIVE, MX-*` OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-90 PAGE: 1B3
STUDY NUMBER: 964080
ANIMAL NUMBER: 2503 DATE OF DEATH: 05/27/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
292.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
GROSS:'-Implant SCARS - PRESENT ...................................... -RiGHT: 7;'lEFT:'6.......................................................................
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003456
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE C0K6INE0 INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRIMED: Z9-APR-9B RAGE: 1B4
STUDY NUMBER: 964080
ANIMAL NUM8ER: 2504 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF DEATH: 144
STUOY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
314.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
UTERUS . .
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 6; LEFT: 4
*** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INOIVIOUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 18S
STUDY NUMBER: 964060
ANIMAL NUMBER: 2505 DATE OF DEATH: 05/29/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 143
STUDY WEEK OF OEATH: 21
TERMINAL BODY WEIGHT: 280.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
UTERUS . .
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 10; LEFT: 3
*** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
BFG 003458
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXtCITY STUDY IN CD RATS
INDIVIDUAL AKIHAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 186
STUDY NUMBER: 964080
ANIMAL NUMBER: 2506 DATE OF DEATH: 05/27/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULEO, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 296.6 GRANS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL, FOCAL GROSS: -IMPLANT SCARS - PRESENT
-ACUTE/SUBACUTE INFLAMMATION -RIGHT: 5; LEFT: 8
KEY TO NEOPLASMS: "H-" MALIGNANT. "B-" BENIGN. MS-" METASTATIC, "l-" INVASIVE. "X-" OTHER
ANIMAL NUMBER: 2507 OATE OF DEATH: 05/29/97
ORGAN NAME
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 187
STUOY NUMBER: 964080
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 143
STUDY WEEK OF DEATH: 21
TERMINAL BOOY WEIGHT:
290.7 GRAMS
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
MICRO: -MINIMAL GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -RIGHT: 6; LEFT: 10
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
BPG 003460
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTEO: 29-APR-S6 PAGE: 186
STUDY NUMBER: 964080
ANIMAL NUMBER: 2508 DATE OF OEATH: 06/06/97
SEX: FEMALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 151
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT:
282.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NQN-ZONAL) -RIGHT: 10; LEFT: 5
KEY TO NEOPLASMS: "H-" MALIGNANT, "B-H BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COHBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 189
STUDY NUMBER: 964060
ANIMAL NUMBER: 2509 OATE OF DEATH: 05/29/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 143
STUOY WEEK OF DEATH: 21
TERMINAL BOOY WEI6HT: 319.1 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS *** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOtNGS
LIVER UTERUS
......................................
MICRO: -MINIMAL ......................................
GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -RIGHT: 9; LEFT: 4
KEY TO NEOPLASMS:
MALIGNANT, "B-" BENIGN. "S-" METASTATIC, "I-" INVASIVE. "X-" OTHER
BFG 003462
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 190
STUDY NUM6ER: 964000
ANIMAL NUMBER: 2510 DATE OF DEATH: 0S/Z8/97
ORGAN NAME
SEX: FEMALE
DOSE GROUP; Z
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 142
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 281.0 GRAMS
* * * PATHOLOGY KEYWOROS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
..................................... MICRO: -MINIMAL
..................................... GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -RIGHT: 4; LEFT: 8
KEY TO NEOPLASMS: "H-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003463
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 191
STUOY NUMBER: 964080
ANIMAL NUMBER: 2511 DATE OF OEATH: 05/27/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF OEATH: 141
STUDY WEEK OF OEATH: 21
TERMINAL BODY WEIGHT:
264.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS .
MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
GROSS: -IMPLANT SCARS - PRESENT ...................................... -RIGHT: S: LEFT:*
KEY TO NEOPLASMS: "H-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-H OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 192
STUDY NUMBER: 964080
ANIMAL NUMBER: 2512 DATE OF DEATH: 05/30/9?
SEX: FEMALE
DOSE GROUP: Z
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUOY DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
273.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEYS UTERUS . .
GROSS: -DILATATION, SLIGHT GROSS: -IMPLANT SCARS - NOT PRESENT
-RIGHT PELVIS
*** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVCO ***
BFG 003464
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTEO: 29-APR-98 PAGE: 193
STUDY NUMBER: 9640B0
ANIMAL NUMBER: 2513 DATE OF DEATH: 05/30/97
ORGAN NAME
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY OAY OF OEATH: 144
STUOY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 255.8 GRANS.
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL. FOCAL GROSS: -IMPLANT SCARS - PRESENT
-ACUTE/SUBACUTE INFLAMMATION -RIGHT: 8; LEFT: 8
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003-465
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 194
STUOY NUMBER: 964080
ANIMAL NUMBER: 2514 DATE OF DEATH: 05/28/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH; 142
STUDY WEEK OF DEATH: 21
TERMINAL BOOY WEIGHT: 296.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
UTERUS .............................. GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 4; LEFT: 10
*** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 195
STUDY NUMBER: 964080
ANIMAL NUMBER: 2515 DATE OF OEATH: 05/27/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
325.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
..............................................................................................................................................................................................................................................................................
MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
........................................................................................................................................................................................................................................................
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 9; LEFT: 7
KEY TO NEOPLASMS: "H-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE, "X-" OTHER
BFG 003467
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL OATA SHEET
PRINTED: 29-APR-98 PAGE: 196
STUOY NUMBER: 964060
ANIMAL NUMBER: 2516 DATE OF DEATH: 05/30/97
SEX: FEMALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF OEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BOOY WEIGHT:
304.6 GRAMS
ORGAN NAME
* * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
MICRO: -MINIMAL, FOCAL -MINIMAL
-ACUTE/SUBACUTE INFLAMMATION -HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL)
GROSS: -iMPLANT SCARS - PRESENT ...................................... -RiGHT: 4;'LEFT:*......................................................................
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC, ''I-*' INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-9B PAGE: 197
STUDY NUMBER: 964080
ANIMAL NUMBER: 2517 DATE OF DEATH: 05/27/97
ORGAN NAME
SEX: FEMALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUOY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 290.8 GRAMS
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NQN-ZONAL) -RI6HT: 12: LEFT: 5
KEY TO NEOPLASMS: "M-" MALIGNANT. HB-" BENIGN, "S-" METASTATIC,
INVASIVE. "X-" OTHER
BFG 003469
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 198
STUDY NUMBER: 964060
ANIMAL NUMBER: 2SLB DATE OF DEATH: 05/30/97
SEX: FEMALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY Of OEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
310.6 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -RIGHT: 6; LEFT: 9
KEY TO NEOPLASMS: '*M-" MALIGNANT, "B-" BENIGN. 'V* METASTATIC. "1-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: Z9-APR-98 PAGE: 199
STUDY NUMBER: 964080
ANIMAL NUMBER: 2519 DATE OF DEATH: 05/29/97
SEX: FEMALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 143
STUOY WEEK OF DEATH: 21
TERMINAL BOOY WEIGHT: 303.3 6RAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
UTERUS . .
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 4; LEFT: 3
*** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVEO ***
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*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TU0-6ENERATI0N REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-90 PAGE: 201
STUDY NUMBER: 964000
ANIMAL NUMBER: 2521 DATE OF DEATH: 05/2B/97
SEX: FEMALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 142
STUDY WEEK OF OEATH: 21
TERMINAL BOOY WEIGHT: 256.2 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREC-TEXT COMMENTS f HISTOPATHOLOGIC FINDINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -RIGHT: 10; LEFT: 6
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. MX-M OTHER
BFG 003473
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COM8INED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 202
STUDY NUMBER: 964080
ANIMAL NUMBER: 2522 DATE OF DEATH: 05/27/97
ORGAN NAME
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BOOT WEIGHT:
309.7 GRAMS
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * * * 6R0SS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
MICRO: -MINIMAL
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NQN-ZQNAL)
GROSS:'-iMPLANT SCARS - PRESENT ...................................... -RiGHT! ; LEFT: B......................................................................
KEY TO NEOPLASMS: "M-" MALIGNANT. '*B-" BENIGN, "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMB1NEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 203
STUDY NUMBER: 964080
ANIMAL NUMBER: 2S23 DATE OF OEATH: 05/27/97
ORGAN NAME
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
286.7 GRAMS
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
UTERUS . .
GROSS: -IMPLANT SCARS - PRESENT
-RIGHT: 8; LEFT: 7
*** ANIMAL HAS NO MICROSCOPIC ABNORMALITIES OBSERVED ***
BFG 003475
*** PATH/TOX SYSTEM OUTPUT *** , VINYL CHLORIDE COMBINED INHALATION TWQ-6ENERAT10N REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PACE: 204
STUDY NUMBER: 964080
ANIMAL NUMBER: 2524 DATE OF OEATH: 05/29/97
ORGAN HAME
SEX: FEMALE
OOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF OEATH: 143
STUOY WEEK OF OEATH: 21
TERMINAL BOOY WEIGHT: 274.4 GRANS
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FRCE-TEXT COMHENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
...................................... MICRO: -MINIMAL
...................................... GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NQM-ZONAL) -RIGHT: 6; LEFT: 6
KEY TO NEOPLASMS: MM-*` MALIGNANT. "B-" BENIGN, MS-" METASTATIC, "1-** INVASIVE. "X-" OTHER
* * * PATH/TOX SYSTEM OUTPUT * * *
V IN Y L CHLORIDE COMBINED IN H A LA TIO N TW 0-6ENERATI0N REPRODUCTION AND DEVELOPMENTAL T O X IC IT Y STUDY IN CO RATS
PRINTED: 29-A P R -98 PAGE: 205
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BFG 003477
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 206
STUOY NUMBER: 964080
ANIMAL NUMBER: 2S26 DATE OF DEATH: 0S/2B/97
SEX: FEMALE
DOSE 6R0UP: 2
SACRIFICE STATUS: SCHEOULEO. TERMINAL SACRIFICE
STUOY DAY OF OEATH: 142
STUOY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
298.9 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
MICRO: -MINIMAL, MULTI-FOCAL
-ACUTE/SUBACUTE INFLAMMATION
GROSS:`-iMPLANT SCARS - PRESENT ................................... -RiGHT: 6;'LEFT:'&....................
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" BENIGN. "$-" METASTATIC. ,,I-,` INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMfllNED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 207
STUDY NUMBER: 964060
ANIMAL NUMBER: 2527 DATE OF DEATH: 05/28/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 142
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 275.0 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL GROSS: -IMPLANT SCARS - PRESENT
KEPATOCYTES: CYTOPLASMIC VACUOLES (N0N-20NAL) -RIGHT: 6; LEFT: 8
KEY TO NEOPLASMS: "M-" MALIGNANT. "B-" 8ENIGN, "S-" METASTATIC, "I-" INVASIVE. "X- OTHER
BFG 003479
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-9B PAGE: 208
STUDY NUMBER: 964080
ANIMAL NUMBER: 2528 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEOUIEO, TERMINAL SACRIFICE
STUOr DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 273.7 GRANS
ORGAN NAHE
* * * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
0 BSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
-. ..
MICRO; MINIMAL 6R0SS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NQN-ZONAL) -RIGHT: 3; LEFT: 10
KEY TO NEOPLASMS: "H-" MALIGNANT, "B-" BENIGN , "S-M METASTATIC, "I-" INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TU0-6ENERATI0N REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 209
STUDY NUMBER: 964080
ANIMAL NUMBER: 2530 DATE OF DEATH: 05/27/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 279.4 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
MICRO: -MINIMAL -MINIMAL
GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
-RIGHT: 6; LEFT: 4
KEY TO NEOPLASMS: "H-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC, "1-" INVASIVE, "X-M OTHER
BFG 003481
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 210
STUDY NUMBER: 964080
ANIMAL NUMBER: 2531 DATE OF DEATH: 06/05/97
SEX: FEMALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 150
STUOY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 276.7 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NQN-ZONAL) -RIGHT: 10; LEFT: 4
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN, "S-" METASTATIC. "I-*' INVASIVE, HX-M OTHER
BFG 003482
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHL0RI0E COMBINED INHALATION TW0-6ENERATI0N REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 211
STUDY NUMBER: 9640B0
ANIMAL NUMBER: 3501 DATE OF DEATH: OS/27/97
SEX: FEMALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF OEATH: 141
STUOY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 305.2 6RAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
MICRO: -MINIMAL -MINIMAL
GROSS: -IMPLANT SCARS - NOT PRESENT
-HEPATOCYTES: CYTOPLASMIC VACUOLES (NON-ZONAL) -HEPATOCYTES CENTR1LOBULAR: HYPERTROPHY
KEY TO NEOPLASMS: "M-M MALIGNANT. "B-" BENIGN. "S-" METASTATIC. "I-" INVASIVE. "X-" OTHER
BFG 003483
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 212
STUDY NUMBER: 9640B0
ANIMAL NUMBER: 3502 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUOY OAY OF DEATH; 144
STUOY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT: 2B2.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
.................................. MICRO: -MINIMAL. FOCAL -MINIMAL
.................................. GROSS: -IMPLANT SCARS -
PRESENT
-ACUTE/SUBACUTE INFLAMMATION -KEPATOCITCS CENTRlLOBULAR: HYPERTROPHY
-RIGHT: 4; LEFT: 11
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN,
METASTATIC.
INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICtTY STUDY IN CO RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTED: 29-APR-98 PAGE: 213
STUDY NUMBER: 964080
ANIMAL NUMBER: 3503 DATE OK DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BOOY VEI6HT: 328.5 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * * * 6R0SS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER . . UTERUS . .
MICRO: -MINIMAL GROSS: -IMPLANT SCARS - PRESENT
-HEPATOCYTES CENTRIL08ULAR: HYPERTROPHY -RIGHT: 13; LEFT: 7
KEY TO NEOPLASMS: "M-" MALIGNANT, "8-m 8ENIGN. MS-" METASTATIC, ''I-" INVASIVE. "X-" OTHER
BFG 003485
*** PATM/TOX SYSTEM OUTPUT *** VINYL CHLORIDE COMBINED INHALATION TUO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS
INOIVIOUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-98 PAGE: 214
STUDY NUMBER: 9B4060
ANIMAL NUMBER: 3504 DATE OF DEATH: 05/26/97
ORGAN NAME
SEX: FEMALE
DOSE 6R0UP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
STUDY DAY OF DEATH: 142
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
272.1 SRAMS
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
MICRO: -MINIMAL
-HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
gross:'-Implant scars - present ................................... -right- 7;'left: b..................................................
KEY TO NEOPLASMS: "M-" MALIGNANT. "fl-" BENIGN, "S-" METASTATIC, "I-" INVASIVE, "X-" OTHER
*** PATH/TOX SYSTEM OUTPUT *** VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
INDIVIDUAL ANIMAL DATA SHEET
PRINTEO: 29-APR-9B PAGE: 215
STUOY NUMBER: 964080
ANIMAL NUMBER: 3505 DATE OF DEATH: 05/30/97
SEX: FEMALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
STUDY DAY OF DEATH: 144
STUDY WEEK OF DEATH: 21
TERMINAL BODY WEIGHT:
289.3 GRAMS
ORGAN NAME
* * * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * * * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER UTERUS
MICRO: -MINIMAL
-HEPATOCYTES CENTRILOBULAR: HYPERTROPHY
GROSS: -iMPLANT SCARS : PRESENT................................... -RiGHT: 6;'LEFT:*7......................................................
KEY TO NEOPLASMS: "M-" MALIGNANT, "B-" BENIGN. "S-" METASTATIC. "I-** INVASIVE, "X-M OTHER
BFG 003487