Document wqpzzppZgLO39aGNpeNj1bOa4

Ootcbar l$6a To HJiin at tb Baalth aod Safatjr Cardttaa* Attacbad 1* Wkpxwl lsfocactlco raoalvud tram Dr. DorfbTM at tha Voroaatar Baaaarch ftesdatloo eovorl&c Itaa Vo. % a* our propoaad caoda for tfea Icnrofear 13 Haalth and Safbtar C*alttaa Maatlof. Tlaaaa bo prtparad do dlacuaa thla aa poaalfela laduatry* t- .... opooaarad product. Yary truly jroun. EQPiad eei Or. T. B. Labadaff Sen 0. Bovlar aorataxy W : J! .'if : i ns worczsm po u c at ic b ron npnuxwiAL bio l o o t Shrevsbury, Mssse&usstts Octdber 22, 1962 h eeas c h raarar Tot LmS Industry CcsalttM 292 MIm Anon m York 17, Bsv lark Title of Bss--reht Qensrel Btetemeoti m name or o c a b o iz a d o o k po w d o TOR POSSIBLE ntDOCKDCLCCICAL AID Axn-MUMUs t u c k Acmrrx. Or. Mslcola C. 8*017 of Betlek, kmebosetts, bM cleen sod Intend* to continue to (It * ua various orfeaoleed eoapounls for testing. In tbs pest wa be** elreedy found sens oespouoda vltb possible important utilities. Vs vish to eootlnu* tb*M studies. Our tests will Include androgenic activity (b*1* mx boraooe), estrogenic activity (faaala mx bomae), aotl-estroaeale (possible sotl-tusor activity), antlandrogenic activity (poeslble traatnant of pro*tatlo cancer), and *atltnfl--trwy activity (po**Ibl* treataent for thelit nId arthritis and allergic <1h i i i ). W* abould *l*o b* pleased to (tody orgmolead ccspounds frea other sources. MMi Deoafeer 1, 1962 to londMr 30, 1963 1 BIo mmt Technician 5,000 Beta, Klo* and Chicks * 3,000 Ccosiwahla Supplies . 1.000- Plr*ot Coots # > 9.000 Indirect Costa By} #* . 2.290 TOTAL >11.256 KB/ KBOCSI KMOIAm, fb. D., 6*. D. Executive Dlr*ctor oraocnr mcui, b*. d . Aeseereh D1lector S&b Darfnan" warn i. Dosntui, t b. r. Director of LsboretorlM IWCt CHAW70BD Busla*ss Meager N 330.01 .^*r>/^.vYvA/'I/v^V../r:XSwv-.'I-.,'^.V.y,.',f.... i * -: .. .-wim i vs o m WfCBTEH rCXUDATIC* POX ECPXHDCnrrAL BIOLOOT flbravabus7# Muaacbuaatta PJOOKEB8 KKPOKT TO IS! UU) KE8BUCB COMOm 8*0x17 X to Aogurt Jl, 1J62 taeloaad art 10 tablaa vblcb txaaarlia cur aotlvltiaa with orpaolaad compound* ovar tlx part L*ht aootba. Baa twcty-tvo eoynli van auppllad to u by Er. balcola Baary durlac tbla period. Bxaa eoapouada ara llatad by ooda aofcar aad aaaa. Bx TVfelaa 8 through 8 Hat tlx raaulta. Bo activity mi dataotad vtxa tba ooc^ouoAl vara taatad aa poaatbla famla ax bcracaaa (Tablaa 8 and 3). Tibia * prtaasta tba rvrult* or coapouodi EP-1, HP-7 aad HP-1J vblefa ahowad atatlatlcally ald&ifloast astl-aadroamta activity on tba eblck'a ocafe. Compound HP-1J vaa aetlva aa aa aotl-ar>4rorn la tba rat but Koa toxicity vaa cbaarrad. Aatl-aadrocaalc activity la tba rat-vaa alao cfcaarrvd at tba 8 ( laval (labia 7). Coaqpoiada vltb thla typa cT activity could bo valuable tharapautlo acesta la proatatla eaaoar, aaaoullalaad voaao dua to ovarian or adraoal oaaoar, aad eould poaatbly ba eT l^ortaaoo la meat, baldoaaa, aad aa co^cwada to Inhibit board groutb la aaa. la Tibia 9 KP-13 aad EP-lb aay bava aoaa anillnflanatory activity. Ca^ouoda vltb tbla typa at jbaraacolodloal activity ara uaually valuable la rtxvaatpld arthritic, allarglaa, aad aatbaa. KB/* Xao. BaapactfuHy aubalttad, lcaadi Ibljfc S. Docfbaa Buteod BCiMim, lb. D., 8a. 8. Xxacutlva draotor oraoonr k b c u b, b. d . Aaaaarob Dlraotor p a l p s x. cornu, lb. 8. Dlraotor or Laboratorlao BHUCX CMVTOXD fualaaaa Maaacar N 330.02 r.. y ~;vr^; i: fc. `1 ,2*1 1 ORMVOUAO 00W0OO8 Cod IPX PS 03 IPX OJ 00 0T 00 IP9 'V'': ' IP 10 ' IP 12 IP 13 IP IX . 01# : 010 01T 010 ' 0 19 0 SO 0a 0 S3 - fctnjfcaarllMd TrijfcMjrllMia CXlorlO* ,t U^MgrllMd X&fclcrlOa i dji>*C7llMd BHwtoX > ,, BiaHrltfaatqrllMA MlsfelO* TrijfcwylarttafllMl trljlMagrithbBraqrlXMd ttjfcwafaXlcroXMl Ao*tto V '.&lMttqrltrlil>apUMA ? ThleprofgrltrljfanarllMA TMribwwyltrlittyll--d IMcjhojrlUljlMngrUMS IbioMtjrltrljSMagrUMd Th1fWii-crltrijb>Tyn--I Lm* Mrtfcyl tferaptlfe v -v lm& Ittjrl NnfMptlte U4 1-projgrl Hmaptlda U*1 1-twtjrl Mtrsuptld* Lm4 Bmqrl >fcroptl4 UtA tttloihmolrt* iWV . ^-v >% ~%$M':: - N 330.03 * v . ;1 V ,.*35"j .A >>-' ^ '*./S,/ **^^j V- .V*.:'!- --?>V'i * 4 nu t nt utwasn* rpucajiar k m mnoena k o l o o y tbmnmixri m--etmtna ASSAI WOW Brtre**e Aangr (MctUttoui bjNtla) Oiftadttad byi (OlM Th Mi Trt Anlaalt WiLelat ItwtAnt Dr. Inqr Al IHM Mo o m, fwli, l?^l-dy-old 8i iii oU, 0.1 al. par iajteUo XBjactad c o m daily for 3 coMevtln day* aad autopcy oa Vth d^r. Mttarlal 0 iatroo* K? 1 SP 2 5? pT~ ep a ET5 EPu E? 12 EP 1) kMi"1 w i5'"'" ' fUDt, wn pis BP 26 EPTI :z total Po m 0 '" 6.6} 0.1 1 M. 1 M. 1 BAa * . 1 w. 1 BA. 1 a*. 1 a*. 1 M. 1 C*. U' . 1 nt. 1 BAa 11*. 1 ae. 1 a. 1 vt. 1 M. 1 BA* X BA. J-A fc. of Mmb Otarlaa Klaa n>tio - e.x. ------- b.eoTo.or [ a rsrnrK e 1.61 - 0.106 t 5 o.e 1 1 0.668 ___ 0.7! > * 6.626" 6.8 3*6. ilBTM 6 0.91 * 0.109 & 0.71 * O.OkL i6 O.H 6.6 6 t>M * 0.092 ALL LEAD 5 .. .. 1.0' r $*rt-- 6 * 0.106 6 A.f *"5.636 6 ill fce> 6.K * o.oii ` 3 575! i.oe' O o.a! '* 6.69 6 6.51 1 6.6a a l.OJ * 0.07'! b .. . o.w * 6.6y '4 _____ * 0.1IJ *~7:66r N 330.04 -!1 "H Woro*rt*r Toundotleo Tar txpariaautal Biology 6trvbaT7; Haaaachua.tf frtelttad byj Pallia. Tatad Toot Aolaolt Tohlolot hcotoii Itetorlol Adsrtoloterod 0 BrtroDi HT-15 i-ao 1*21 lotrogon Aoooy (Mbcutoaaou* lajoetloe) Mouao, ftool*, lj-il-dy old S4M0M oil/ 0.1 al. par la^ootloa Injoctod o bo o dolly for 3 eoooocutloo doyo ad outopay oo kth doy. ToUl Io n * >0. c* Kloa Mmo OtorlM Ratio a 8.B. 0 10 o.fT t 0.0fcs 0.0$ 0.1 0.2 0.k 10 10 9; 10 r 1.6k 1-0.223 , 1.53 * 0.121$ ,3.55 t 0.323 v (.3310.193 *|^V 100 t 0.66 t 0.068 - " l 10 0.63 t 0.0T6 . 10 10 1.0110.04r .-* 100 10 O.63 t 0.055 X 10 0.8fc t O.053 -<h' 10 10 1.15 t 0.096 dWSMy100 10 0.6( 1 0.008 -*?' ' N 330.05 f - 'is " ' '' V "te:km.ar 'r !' Vcre**tar fantotlce for Exparlaastal Blolocy ShrmVurjr, N*****u**tt# Tibia % ASSAY ROOH Chick Autl-An4ro**n A*#y Subaittai by: Or. Haoxy 6apl** Tt*4i A* Llat*4 T*t tay>oU Bela %falt Leghorn Oili>. Vahielat IntoiUrtsi cncnthat*, M-- oil, 0.$ (L Tut cat*rial, mat oil* 0.0$ al. par Inaction. fnottott 0a flr*t toy chick* ax* lnjactad c o m vlth t**to*t*rce* acaotbct*. Retiming co aaaa lv lourt teat aeterlal coo* tolly for 7 tojra and autepay cn 6th toy. rut Muntiia fetal Do** _*fc_ T*to*t*roo* Zaastbat* Total Do** *. O 6TT T<r 07 07 0.5 075 6.5 0.5 075 o.5 o7 07 07 03 oTj 075 0.5 0.5 Ro. of Chick* 12 ur TO* 10 To * TO- * TO TO TO- TO" 15" TO" 10 3 Boy vt. _JL_ Mms Co * Ratio t 8. R. o.ga * 6.<5IT 11 o.ouj T-6l06S~ :6.W "* O.Obl "6Ti5To: ` 0.9___________ *0.c6 *' 0.055" 1.061 i 0. 0.92 X 0.1 Tesrhre 1.19 * 6.060T '1.21 Vp-OST 1.15 t Q.16T 1.15 * olbT "6.95 i fcosr -6.fi'r-g~.(gr "TTST TT $4i. o.oea N 330.06 m.`4 ' i' I * Vaaeartar Pouadatlco for Expcrlaeotal Blolcyp Ghr*v*bu>7, NuMcbUMtt* ran 5 ASSAY REPORT 6itltt4 hpi B*apl Tactadt Ttit Aaladi Vahlelat Chick Aotl-Andro*n Aimj t Dr. Ml Is c Ic c . 8*117 8-15 Dtj-oU aal* hlt* labors Chick. T*rto*Urca* *n*nth*t, mmm oil, 0.1 al* Trt a*Url*l, mn s oil, 0.0$ al. per Y ProotOuwi Cb flret 6ty chick* m lc3ct*d coo* with t**torUroo* &acth*tc. Bcglimlsc ca HM 0*7 luuact t*rt a*trUl ooo* 4*117 for 7 4*7* aed *utop7 ao 8th 6*7. TEST MAXIRIAL T*tcrtrce* Total Ibasthat* Do** Total Co m D#ixn*tlon m. ,, .....H-. .... 0 ... . 00 0.3 BO. of (hick* M**a B047 Vt. 8* .. N*aa Co* - ' . ratio i s. x. "* 12 38 ,. 0.68 * r 9 60 1.23 0.093 Ro 2-7239 1 0.5 0.3 0.3 9 57 0.66 t 0.03V 9 60 1.03 1 0.09V IT W 3 0.5 10 5T 1.83 t 0.108 N 330.07 V# fail# Voro*rtr FotanUtlca for txptrlwmntil Blolefjr Shrortfcuty, MMMobnatta ASSAY EXPORT tat Astl-Acdrqpa Uttgr (isOaotlon) MsltM tn 1 3 6--pi-- Trtd| 1 T**t talrti tat, Mil, 2X>tajr-ol4. k Yahlclti Tirtortiroc*, OC, 0.5 *1. par lAjMtlo* Trt Mtiriil, OC, 0.5 *1. P*r Injaatloa Frooatarti C*rtrt* 21rt - 26th tajr of Ilf*.' tacJjelo* on mm tay, atatnlatar trMtMot* it Mp*r*l* sit** c d o * tally for 7 tail nt wtowr oa 6th taqr. % nsr NHORZAL Total Co m Pe*l3*tlea Taatoatarcna taa* Total BoGjr Co m Vo* of vt. nti _f- . t x s s u i mno 10. *. ProotcU Ytftklc Lmkr Aol m0 00 7 76 o.isto.019 o.ioto.oca 0.2*10.032 Y*rto*traM 0 2 10 62 1.3010.108 1.1210.0T7 0.7*10.033 * Troftatarcea 125 2 10 88 1.0710.058 0.7210.0*5 o.5&o.oer 250 10 3 1.1010.066 0.7010.056 0.5*10.00* IT- 50 2 0"* N 330.08 *.V; ;V/ 1 6 Ttfela T Varoertar fouaiatlao far Ezptrlmotal Biology EJirrrtbury, MuMrtwtti a s s a y nras M AottWWnfM Amy (Xnjaetical BiislHed Byj T**te6j T#t Alii wit Yafalaltj IVooftCTi Dr. I*1bo Xb Bassry Kf-15 Rat, Hit, 21-day-old. Taatoatarooa, OC, 0.9 >1. pr lnjactim Trt arterial, OC, 0.J si. per Injectlea Caatrete 2I*t 28th day of life. Setlmlng ce am* 6*7, xfrrlnlrter tmtanti at Mptnt* alto* oaee 0*1ly for T 6*y* and autopay to 6tk day. TBT mTDOAL Total Doaa Daalxsatlcs M. Ytatoataroo* Total Doaa M. Mm Body T1S8B RATIO * 8. s. 80. of Vt. flaalnal tot* ___rroatata____Veticlf___lavvtor_Aal . 0 0 0 10 65 o.ivio.on o.ioio.013 0.29*0.018 .0 0 8.0 10 fc 1.13*0.076 o.epo.ckk 0.97*0.030 BT-19 8 8.0 8 76 1.01*0.063 0.93*0.066 0.53*0.037 IT-15* 10 8.0 7 a o.^.on 0.19*0.032 0.35*0.0A MJH 20 8.0 ALL BAD BP-15*** 90 8 Data rry alok ** AU dead on 9th Say *** All 4*ad on 2nd day ALL BAD i" i* < **9t* ' N 330.09 ' v &^/s'.v*'i:V. '-V\'i^'yy^^. -' >'.;. /,.:' ,,' y . .'.rv.-v- _ Sf , : p$.?* -?\ &K-. t?> TObl* 6 Cm Coaolytlc and Aatl-Inflc--tocy Activity of KU, B, nl C, EP-1, 2, 3, cod % 1b tbc AdrcmlcetBla4 Bet *- v Ifctcrlal '- \ -... * *;. - ' ,.:V ; '* .*> Total 1BXNDB CHT Bo m Bo. of Nmb &j mm .--JBkU___nti t ajg. ABTI-IJOlAJMkrotOr TBf Bo. of tMaDiyTUmo . wt. mf. t .. ' . syj 0 0 7 1.33 * 0.81* T 33-8*1^77 CcrtUol IM O.J 9 3.72* 0.37*8 M 10 ua* 0.129 e 5 1.1210.328 9 10 3 . 33- * 8.337. 15.1 * 1.331 87.7*1.7*7 ..-,v ^ .''i, V-^V' ^ .Vm* IM . ........ MS 8 6 04 8 . Alt X1AP fe*. ,-;-* n All HAD - All. SCAD " r'*tyr*v<i^ Pr -i-r' 't*v. ... . , ,c- v;.. .* * \ y'**' } 4 '**,>4^'' -A / v,-- i.v , -v. r.:.;\ , 'snqg&ir *isr\-: - r' - , ** .-5 z&rtatirwm ' - &+ : ' -r A" . "; .. . t;. *. yX-i > : .'T, t4 ., >.. 'tAffStcAii ;^-:..'.<. :ifc_,:*V :> .lii*-'.... N 330.1 Ttf>U 9 Txt tRoctanc a h d txn-anjtnaoKt tarrm bp 5* 6, 7, a, 9# n# 12, 13 ik JM TB *ixTM*trmrmrtiTTwn gtg Notarial Total nscB nor Xkwa Bo. of Mas thyaua rni-vanMHatxa ma Bo. of Mm Iqr Ham 0 0 10 3.8610.30a 10 83.kt2.ai5 OJ D( BP? IP 6 k.5 9 8.8k* 0.19k 9 8k.9 t lij) a T 3.a$ * 0.20k 7 80.8 1 1.989 a 3 3.97*0.196 3 . 87.lt s^Q3 , Vy a7 *.1.936^^ a 6 k.56*0.3TT 6 as.iti-aik/ BP 9 a 1 8.86 t 8.090 8 29.113.712 . BP 11 a BP 11 ;-#;j a ALL QM . ALL MAS *, / ;; s - , iHiWiirnr BP 13 a 3 3.061 0.322 3 17.3 * X.8ko BP lk a V k.ko t 0.883 k 16.9 11.380 Certlad o.j a 3.76 t 0.221 a 8k.it 1.816 k 9/ 6, 7# 10, U eofoodi aollaetat nter >&*. N 330.ll Wblo 10 OB UEMQLmC AS) AWI-IOTAJWaacr ACTZ7ZTX Of KP-IJ, 16, 17, 18, 19, 20, 21, 22 -------------- --- Nttarlal 0 Corttaol HP-13 KP-lS HP-lS IP-19 IP-80 IP-Z1 IP-22 Total Co m - ra: t bdc bhsi Bo . of Mmo Ognaa Am-n7iA>*TC)afOHr Bo. et Nm Iky tlm ----S5~* m*, ,t -- 03 o.26l 9 29.5t3.kce 0.5 8 *3 10 3.811 0.388 1.9* t 0.136 8 27.0 t 2.551: 10 37^ 11.083 1 ^ - >'' r 5 * . 8 1 . 5.13 .1 8 , * j6 3.32 .... .... 1 8 8 *.37 * 0.220 8 - .,,236 * 1.33T-V 8 7 *.27 * 0.280 7 27.2 * 2.308 88 \ % 86 1.26 0.129 . . ,,i% 25.7 * 2.766 fc.ofc * 0.187 ^sg*M - * '< :. '-j.- V.3210.273 6 y 21.0tl.tt7 8TH -Syi m :>i| - *. * 4. * ;r *1 N 330.12