Document wqNRZ98aMjqKgwdekv2eJkjg4

3M Specialty Materials 3M Center St. Paul, MN 55144-1000 651 733 111*0 May 23, 2001 Dr. Charles Auer, Director Chemical Control Division/U.S. EPA Office of Pollution Prevention and Toxics 401 M Street, S.W., Mail Code 7405 Washington, DC 20460-0001 Dr. Oscar Hernandez US EPA/OPPT/CCD (7405) 401 M Street, S.W. Room E615B Washington, DC 20460-0001 Gentlemen: Attached for your information is a copy of a recent 3M filing of a TSCA 8(e) Supplemental notice for Sulfonate-based and Carboxylic-based and Carboxylic-based Fluorochemicals. This notice reported on completed analyses of several fluorochemical compounds in individual, stored human sera. We are providing you a copy of this notice in preparation of a conference call I would like to arrange with you and Dr. Larry Zobel, Medical Director to 3M. I will be in contact with you to arrange a mutually acceptable schedule for that call. In the meantime, if you have any questions, please contact me at 651 733-6374. Sincerely, RECEIVED Michael A. Santoro Director, Environmental, Health, Safety & Regulatory Affairs Specialty Material Markets Group 3M Center Bldg. 236-1B-10 St. Paul, Minnesota 55144 o ~"0 IX.- CO C: Dr. Larry Zobel - 220-2E-02 Contain NO GBI CO ro QO 3M Gnrai Offices 3M Center St. Paul, MN 35144-iOOO 612 733 1110 May 15, 2001 Document Processing Center (7407) ATTN: Section 8(e) Coordinator Office of Pollution, Prevention and Toxics US Environmental Protection Agency 401 M Street, SW Washington, D.C. 20460 Re: 7SCA 8(e) Supplemental notice for Sulfonate-based and Carboxylic-based Fluorochemicais-Docket numbers 8EHQ-1180-373; 8EHQ-1180-374; 3EHQ-0381-0394; 8EHQ-0598-373 Dear Docket Coordinator: 3M recently completed analyses o f several fluorochemical compounds in individual, stored human sera We have previously reported results o f perfluorooctane sulfonate for human sera from pooled samples.0 ,0 In the current analyses, individual samples were measured for sulfonate-based and carboxylic-based compounds. Table 1 represents samples of 599 individuals from 23 different states in the U.S. in the age span 2-12. These samples were drawn in 1995. Table 2 represents over 600 individuals from six blood banks across the United States, focusing in the age span 20-69. These samples were drawn in 2006: 3M will send a final report on these analyses to the EPA in the near future. Table 1. Summary o f Samples Drawn in 1995. Ages 2-12 ! Compound Average ! Median i 95* percentile i PFOS C |F17SCV 43.5 ppbu) | 36.7 ppb j 90.2 ppb ! PFHS QFnCOT i PFOSAA i C,,F,7SO,N(ClH,>: CHjCOi' i M570 ' C*FnSOjN(CHj)1 CHjCOi' 15.0 ppb 4.4 ppb 3.4 ppb 3.8 ppb J 3.7 ppb ! 1.8 ppb 71.3 ppb 10.4 ppb 12.5 ppb i PFOSA <LLOQ <LLOQ <LLOQ : C,FI7S 0 2W i M556 3.0 ppb 2.5 ppb 7.3 ppb i CgF I7S 0 2NH- i CHICOT i PFOA CtFmCOT 5.6 ppb 5.1 ppb 10.2 ppb (a) ppb is parts per billion; (b)<LLOQ is less than the lower limit o f quantification Range 6.7-515 ppb <LLOOlll,-712 ppb <LLOQ-23.8 ppb <<-LOQ-48.0 ppb <LLOQ <LLOQ-l9.1 ppb <LLOQ-56.1 ppb Table 2. Summary o f Blood Bank Samples Drawn in 2000, Focusing on Ages 20-69 Compound : p f o s c ,f 17s o t PFHS CfrFnCOT , PFOSAA : CjFi7SON(CiHi)i CH.CCV M570 CjFaSONiCHOCHiCcv PFOSA Average 43.7 ppb 2.9 ppb 3 . 0 ppb j I.S ppb 1 : i <LLOQ Median 35.S ppb 1.6 ppb 1.4 ppb 0.9 ppb <LLQQ 95* percentile 90.5 ppb 9.6 ppb 7.6 ppb 5.3 ppb <LLOQ c1f ;7s o 7n ' M556 '! i <LLOQ <LLOQ <LLQQ CaF17S 0 2NH- CHjCOT ! PFOA C7F,5CO-' i 5.6 ppb i ] 4.7 ppb | IZ9 ppb Rapge____________ <LLOQ-1656 ppb <LLOQ-66.3 ppb <LLOQ_60.I ppb <LLOQ_19.0 ppb <LLOQ <LL0Q-I2.9 ppb <LLOQ-52.3 ppb | Section 8(e) Coordinator May 15, 2001 Page 2 Please contact me at 651-733-5181 for additional questions relative to the above analyses. Sincerely, Larry R. Zobel, MD MPH Staff Vice President & Medical Director 3M Medical Department (1) Letter to TSCA 8(e) Co-ordinator, May 15, 1998 (2) Perfluorooctane Sulfonate: Current Summary of Human Sera and Toxicology, January 21, 1999 V