Document wqGv4wgXJpvND4w7r3k7LNMy4
AR226-1387
M 9 A 6 - IS 7
W ilm in g to n , Dela w a re 19898
POUYM ER W O O U C T S DEPARTM ENT Cx P RiMENTAU station
PERSONAL AND CONFIDENTIAL
May 19, 1981
TO: DR. Y. L. POWER - PPD, Washington Works
FROM: S. S. STAFFORD *>
^
ANALYSIS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 810-190: PRAL Nos. 81-1488-1501; Notebook. Nos. E22514.E26238)
As requested in your letter of 4/14/81 to L. J. Papa, the 14 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table.
As noted there, the analysis was done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 1QZ relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0-01 ppm perfluorooccanoic acid), with a detection limit of 0.004 ppm which can be distinguished from the reagent background but not well quantitated.
Please contact me (772-4440) or L. J, Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be
directed to J. V. Raines or L. F. Percival.
A ttachm ent jah
Keywords: Perfluorooccanoic Acid Perfluorooctanoate Blood Analysis GC
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TABLE I
CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD ill
PfcAL No. Date Sampled
81-1488
4/7/81
81-1489
4/7/81
81-1490
4/7/81
81-1491 '* 4/7/81
81-1492
4/7/81
81-1493
4/7/81
81-1494
4/7/81
81-1495
4/8/81
81-1496
4/8/81
81-1497
4/8/81
81-1498
4/9/81
81-1499
4/10/81
81-1500
4/10/81
81-1501
4/10/81
P.R.No.
Name
REDACTED
REDACTED
GC Analysis
(b)
Dace Analyzed T c z n Ug F/g blood
4/22/81 4/22/81 4/22/81 4/22/81 4/23/81 4/22/81 4/23/81 4/23/81 4/23/81 4/23/81 4/15/81 4/15/81 4/15/81 4/15/81
0.53 0.23 0.41 0.062 0.94 0.048 0.45 0.59 3.5 1.3 2.5 0.28 0.070 0.055
(a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooccanoic Acid in Blood, Cas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard.
(b) Although the analysis is specifically for perfluorooctanoace (acid or salts), concentrations are given in ppm fluorine fpr comparison with the results of
total organic fluorine analyses, (ppm T * 0.688 x ppm perfluorooccanoic acid)
Estimated uncertainty is + 10Z relative standard deviation. The lower limit for quantitation is 0.007 llgF/g. The detection limit is 'v 0.004 pgF/g, but concentrations in that range cannot be well quantitated and are reported as < 0-007. None detected (n.d.) is reported for samples with [Cg] < 0.004 ppm,' which cannot be distinguished from reagent background.
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